@book{Manorenj_2025j, title = {Seizure Semiology in Clinical Practice: From symptom analysis to localization}, author = {Sandhya Manorenj}, url = {https://www.amazon.in/Seizure-Semiology-Clinical-Practice-Localization-ebook/dp/B0GDHS7TFY}, isbn = {9798241833440}, year = {2025}, date = {2025-12-31}, number = { ASIN: ‎ B0GDHS7TFY }, publisher = {Amazon KDP}, edition = {Kindle}, abstract = {Seizure Semiology in Clinical Practice is designed as a practical and clinically oriented guide to understanding seizure manifestations and their localizing and lateralizing value. The book serves as a valuable resource for neurology residents, general medicine residents, epilepsy fellows, budding neurologists, epileptologists, and neurotechnologists by translating bedside observations into meaningful diagnostic insights. Emphasis is placed on real-world application, helping readers correlate seizure behaviors with underlying neuroanatomy and an approach to history taking. By strengthening clinical acumen and improving seizure recognition, this book ultimately supports accurate diagnosis, timely referral, and optimal management, thereby enhancing the quality of care delivered to patients with epilepsy and related seizure disorders.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {book} } @inbook{Ali_2025c, title = {Precision Healthcare: Advancing Patient Care Through Decision Tools, Wearables, and Ethical Considerations}, author = { Shireen Adeeb Mujtaba Ali and Safia Begum and Mohammed Aleemuddin Naveed and Mohammed Naseeruddin Mujahid}, editor = {Neeraj Gupta and Abdelhameed Ibrahim and Bhavesh Vyas and Shobhna Jeet}, url = {https://www.eurekaselect.com/chapter/26828}, doi = {10.2174/9798898813512125010015}, isbn = {9798898813512}, year = {2025}, date = {2025-12-19}, urldate = {2025-12-01}, booktitle = {Precision Healthcare: Patient Care, Decision Tools, Wearables, Legal and Ethical Issues}, pages = {195–205}, publisher = {BENTHAM SCIENCE PUBLISHERS}, keywords = {Central Research Laboratory, Otorhinolaryngology, Respiratory Medicine}, pubstate = {published}, tppubtype = {inbook} } @article{Haq_2025, title = {A study of clinical profile, chest X-ray, ECG changes, and 2D echocardiography in patients with chronic cor pulmonale}, author = {Mohammed Zia ul Haq and Parvaiz Kadloor and Sayed Mohammed Hussain Bangi}, url = {https://ijcva.org/pdf/1fe4afca-adad-4137-be7c-36a5e5ab6910/articles/ijca.2025.73745/179-184.pdf}, doi = {10.4274/ijca.2025.73745}, issn = {2405-819X}, year = {2025}, date = {2025-12-12}, urldate = {2025-12-12}, journal = {International Journal of the Cardiovascular Academy}, volume = {11}, issue = {4}, pages = {179-184}, abstract = {Background and Aim: Chronic obstructive pulmonary disease may result in chronic cor pulmonale, which is defined as right ventricular dilatation and/or hypertrophy resulting from pulmonary hypertension. A non-spesific clinical presentation and limited access to advanced diagnostic tools in resource-constrained settings make early diagnosis challenging. To evaluate the clinical profile and diagnostic findings from chest radiography, electrocardiography (ECG), and two-dimensional echocardiography in patients with clinically confirmed chronic cor pulmonale. Materials and Methods: A retrospective observational study was conducted at a tertiary care center from October 2016 to September 2018. A total of 50 patients aged 30 to 80 years with clinically diagnosed chronic cor pulmonale were enrolled. Clinical symptoms, radiographic changes, ECG findings, pulmonary function tests (PFTs), and echocardiographic parameters were studied. Results: The mean age of patients in our study was 51.7 years, with a male predominance (92%). The most common presenting features included breathlessness (100%), productive cough (100%), swelling of the feet (86%), and loss of appetite (92%). Chronic bronchitis with emphysema was the most frequent etiology, accounting for 58% of cases. Chest X-rays revealed chronic bronchitis with emphysema in 58% of patients, increased transverse cardiac diameter in 40% of patients, and a right descending pulmonary artery diameter greater than 16 mm in 62% of patients. ECG findings included right axis deviation (86%), P pulmonale (74%), low-voltage QRS complexes (52%), and arrhythmias (72%). Obstructive patterns were observed in 96% of PFTs. Echocardiography demonstrated dilation of the right ventricle and right atrium in all patients, right ventricular hypertrophy in 84% of patients, pulmonary hypertension in 90% of patients, and tricuspid regurgitation in 90% of patients. Moderate-to-severe pulmonary hypertension was observed in 74% of patients. Conclusion: In the present study, chronic bronchitis with emphysema was the predominant cause of chronic cor pulmonale among middle-aged males. Multimodal assessment using clinical, radiographic, ECG, and echocardiographic findings enables early diagnosis. Echocardiography serves as a critical tool for evaluating right heart involvement and guiding timely intervention in chronic cor pulmonale.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025h, title = {Evaluation of emergency laparotomy for ileocaecal emergencies a clinicopathology, prognosis, and outcome based study}, author = {Arshiya Fatima and Zaid Mazhar Syed and Syed Mohammed Sajjad Husayni}, url = {https://jccpractice.com/article/evaluation-of-emergency-laparotomy-for-ileocaecal-emergencies-a-clinicopathology-prognosis-and-outcome-based-study-1712/}, doi = {10.61336/jccp/25-11-129}, issn = {2457-7200}, year = {2025}, date = {2025-12-11}, urldate = {2025-12-11}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {11}, pages = {1034-1039}, abstract = {Background and Objectives: Ileocaecal emergencies, such as perforation, blockage, and inflammatory or viral diseases, continue to be prevalent causes of acute abdomen necessitating immediate laparotomy. These disorders are linked to considerable morbidity and mortality, particularly when diagnosis or management is postponed. The current study sought to assess the clinicopathological characteristics, surgical findings, postoperative complications, prognosis, and overall outcomes of patients receiving emergency laparotomy for ileocecal crises. Materials and Methods: Most of the 60 patients were men, and the age group with the most cases was 30 to 50 years old. 95% of the symptoms were stomach pain, followed by vomiting (72%) and stomach distension (60%). The most common causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal blockage (20%), and tuberculosis-related pathology (15%). Loop ileostomy, resection with anastomosis, and primary closure were some of the most common methods used. 35% of patients had complications after surgery, with infections at the surgery site being the most prevalent. Results: Among the 60 patients, the majority were males, with the highest incidence in the 30–50-year age group. The most common presenting symptoms were abdominal pain (95%), vomiting (72%), and abdominal distension (60%). The leading causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal obstruction (20%), and tuberculosis-related pathology (15%). Primary closure, resection with anastomosis, and loop ileostomy were the commonly performed procedures. Postoperative complications occurred in 35% of patients, with surgical site infection being the most frequent. The overall mortality rate was 10%, primarily associated with delayed presentation, septic shock, and extensive peritoneal contamination. Early surgical intervention significantly improved outcomes. Conclusion: Ileocaecal emergencies remain significant clinical issues necessitating rapid diagnosis and quick surgical intervention to mitigate morbidity and mortality. Early presentation, vigorous resuscitation, and suitable surgical interventions are crucial factors influencing positive outcomes. Improving perioperative care and making early referral systems stronger can make patients' chances of getting better even better.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Husayni_2025, title = {Accuracy of pre-operative scoring in predicting difficulty level of laproscopic cholecystectomy}, author = {Syed Mohammed Sajjad Husayni and Arshiya Fatima and Zaid Mazhar Syed}, url = {https://jccpractice.com/article/accuracy-of-pre-operative-scoring-in-predicting-difficulty-level-of-laparoscopic-cholecystectomy--1706/}, doi = {10.61336/jccp/25-11-127}, issn = {2457-7200}, year = {2025}, date = {2025-12-09}, urldate = {2025-12-09}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {11}, pages = {997-1008}, abstract = {Background: Difficult laparoscopic cholecystectomy (DLC) remains a major intraoperative challenge, especially in resource-limited settings where early identification of high-risk cases is crucial for minimizing bile duct injury, operative delays, and conversion to open procedures. Although several predictive systems exist, most are derived from mixed populations or rely on subjective parameters, limiting their applicability in newly developing laparoscopic units. Objective: To validate a preoperative scoring system for predicting difficult laparoscopic cholecystectomy and to establish a modified intraoperative grading score incorporating comprehensive operative parameters. Methods: A prospective cross-sectional study was conducted on 150 patients undergoing elective laparoscopic cholecystectomy for symptomatic cholelithiasis. Preoperative variables were scored using a modified predictor scale, while intraoperative difficulty was graded using an expanded objective score incorporating adhesions, gallbladder distension, BMI, prior surgical scarring, bile/stone spillage, ductal injury, conversion, and ligature method. Diagnostic performance was assessed using sensitivity, specificity, predictive values, and ROC analysis. Multivariate logistic regression identified independent predictors of difficult LC. Results: Based on intraoperative scoring, 28.7% of patients experienced moderate–severe difficulty. The preoperative score demonstrated excellent discriminatory ability (Sensitivity 94.8%, Specificity 96.2%, AUC 0.945). The intraoperative score also performed strongly (Sensitivity 95.8%, Specificity 98.1%, AUC 0.939). Independent predictors of difficult LC included age ≥50 years, history of acute cholecystitis, BMI >30, palpable gallbladder, impacted stone, adhesions burying the gallbladder, dissection time >90 min, bile/stone spillage, and suture ligature requirement. Conclusion: Both the preoperative and modified intraoperative scoring systems demonstrated high diagnostic accuracy and reliability for predicting difficult LC. These scoring tools are simple, objective, reproducible, and particularly valuable in resource-limited settings for optimizing surgical scheduling, assigning appropriate expertise, improving patient counseling, and reducing intraoperative complications. Implementation of these scores may enhance safety and standardize difficulty assessment across surgical teams.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @book{Hasan_2025, title = {The Principles of Pulmonary Diagnosis: Critical Concepts and a Structured Approach}, author = { Ashfaq Hasan}, url = {https://link.springer.com/book/10.1007/978-981-96-7810-5}, doi = {10.1007/978-981-96-7810-5}, isbn = {9789819678105}, year = {2025}, date = {2025-11-23}, urldate = {2025-11-23}, publisher = {Springer Nature Singapore}, edition = {1}, abstract = {By closely integrating pathophysiological concepts into the diagnostic process, this book adopts a strong analytical approach to the diagnosis of pulmonary diseases. A syndrome-based calibrated strategy takes into account confusing similarities and emphasizes key differences between diseases, and helps build valuable concepts that serve the clinician in unravelling diagnostic dilemmas in real-world settings. Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis. The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @article{Qamesa_2025, title = {A comparative study of conservative and surgical intervention in the management of venous leg ulcer}, author = {Ubhatullah Qamesa and T. Naga Raja Ravi Kishore and Satya Srividya Kalluri}, url = {https://healthcare-bulletin.co.uk/article/a-comparative-study-of-conservative-and-surgical-intervention-in-the-management-of-venous-leg-ulcer-4488/}, doi = {10.61336/ejcm/25-11-34}, issn = {2042-4884}, year = {2025}, date = {2025-11-15}, urldate = {2025-11-15}, journal = {European Journal of Cardiovascular Medicine}, volume = {15}, issue = {11}, pages = {229-235}, abstract = {Background:: Venous leg ulcers are chronic, recurring wounds of the lower limbs caused by venous hypertension and valvular incompetence. They represent a major cause of morbidity and impaired quality of life. Although conservative measures such as compression therapy and wound care promote healing, recurrence is common. Surgical correction of venous reflux may offer better long-term outcomes. This study aimed to compare conservative and surgical management in the treatment of venous leg ulcers with respect to healing rate, ulcer size reduction, and duration of recovery. Aim of the study was to evaluate and compare the efficacy of conservative and surgical management in venous ulcer healing, analyze changes in ulcer size at 1 and 2 months, and assess overall healing at 6 months. Materials and Methods: A prospective comparative study was conducted on 60 patients with venous leg ulcers, divided into two groups of 30 each. Group I (Conservative) received regular wound dressing, compression therapy, and sclerotherapy. Group II (Surgical) underwent ligation and stripping of incompetent veins or subfascial perforator ligation. Parameters such as ulcer size, duration, site, and healing status were recorded at baseline, 1 month, 2 months, and 6 months. Statistical analysis was done using unpaired t-test, Chi-square test, and ANOVA, with p < 0.05 considered significant. Results: The mean age was 58.4 ± 7.43 years in the conservative group and 56.1 ± 5.66 years in the surgical group. The medial malleolus was the most common ulcer site (82%). Mean ulcer size reduction was significantly greater in the surgical group (p < 0.0001). After two months, ulcer size decreased to 12.73 ± 2.85 mm in the surgical group and 27.73 ± 4.72 mm in the conservative group. Complete ulcer healing at six months was achieved in 90% of surgical patients and 63.3% of conservative patients (p = 0.0146). Conclusion: Surgical management provides faster and more complete healing compared to conservative methods. While conservative therapy is effective for symptom control, surgical correction of venous incompetence significantly improves healing outcomes and reduces recurrence, making it the preferred treatment modality}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Hadi_2025, title = {Evaluation of body weight/body mass index as a predictor of dengue severity in children}, author = {Mohammad Abdul Hadi and Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v8i1.00076/2025_7_13.pdf}, doi = {10.23921/amp.2025v8i1.00076}, issn = {2456-8422}, year = {2025}, date = {2025-10-31}, urldate = {2025-10-31}, journal = {Annals of Medical Physiology}, volume = {8}, issue = {1}, pages = {7-13}, abstract = {Higher body mass index (BMI) is a risk factor for many non-communicable diseases and certain infectious diseases. Very less evidence is available that links body mass with dengue severity especially in children. The aim of this study was to evaluate any association between body weight/body mass index of children with severity of dengue illness. A retrospective, medical-records based observational study was conducted on 100 dengue-infected children in the age group of 2-15 years between August and October 2023. Dengue serology, complete blood picture, liver enzymes and coagulation profile were noted along with recording of anthropometric parameters like height and weight at the time of admission. Based on clinical presentation, patients were classified as severe and non-severe dengue. Most of the admitted dengue infected children belonged to underweight (67%) and normal weight (27%) category. The patients were divided into 2 groups: Group 1 included patients in the age group of 2-5 years where the independent variable considered was z-score for weight-for-age and Group 2 included patients between >5-15 years where z-score for BMI-for-age was taken as independent variable. Binomial logistic regression analysis was done to correctly classify the cases as non-severe and severe based on z-scores of weight-for-age / BMI-for-age (independent variable) of the effected children which was statistically significant in group 2 (p=0.000). The model correctly classified 61.8% of cases in group 1 and 86.4% of cases in group 2. Though the majority of cases were in underweight or normal weight category, the results indicate that those with higher weight and BMI for their age and gender are more likely to develop severe dengue infection.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Begum_2025b, title = {Spontaneous pneumomediastinum in acute severe asthma: A case report}, author = { Syeda Tasneem Begum and Mohammed Abdul Basith and Asfa Durdana and Ashfaq Hasan and Mohammed Aleemuddin Naveed and Fahad Abdullah Bin Briek and Syed Mahmood Ahmed and Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/jdrntruhs/fulltext/2025/10000/spontaneous_pneumomediastinum_in_acute_severe.13.aspx}, doi = {10.4103/jdrntruhs.jdrntruhs_37_24}, issn = {2277-8632}, year = {2025}, date = {2025-10-31}, urldate = {2025-10-01}, journal = {Journal of Dr. NTR University of Health Sciences}, volume = {14}, issue = {4}, pages = {434–437}, publisher = {Wolters Kluwer Health}, abstract = {Spontaneous pneumomediastinum (SPM), also known as mediastinal emphysema, develops as a consequence of acute severe asthma and is an uncommon entity. It is essential to recognize this complication since it must be distinguished from other potentially fatal illnesses. The purpose of presenting this case report is to highlight its importance, consider it in the differential diagnosis (d/d) of various problems resulting from acute severe asthma, and provide a detailed explanation of its management strategy.}, keywords = {Central Research Laboratory, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Kishore_2025, title = {Revalidating preoperative prediction score and to develop a more accurate prediction score-to predict difficult cholecystectomy}, author = {T. Naga Raja Ravi Kishore and Ishrath Anjum and Zaid Mazhar Syed and Satya Srividya Kalluri and Syed Asif Shah Harooni}, url = {https://jccpractice.com/article/revalidating-preoperative-prediction-score-and-to-develop-a-more-accurate-prediction-score-to-predict-difficult-cholecystectomy-1502/}, doi = {10.61336/jccp/25-10-89}, issn = {2457-7200}, year = {2025}, date = {2025-10-24}, urldate = {2025-10-24}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {10}, pages = {648-657}, abstract = {Background: Laparoscopic cholecystectomy is the gold standard for symptomatic gallstone disease due to its minimally invasive nature and faster recovery. However, intraoperative challenges can increase the risk of conversion and complications. Predicting surgical difficulty preoperatively enables better planning and patient safety. This study aimed to design and validate a scoring system to predict laparoscopic cholecystectomy difficulty using clinical and imaging parameters. Materials and Methods: A prospective study was conducted on 50 patients undergoing laparoscopic cholecystectomy at Princess Esra Hospital and Owaisi Hospital & Research Centre, Hyderabad, after obtaining ethical clearance. Clinical, biochemical, and imaging findings were analyzed, and scoring parameters were formulated to predict surgical difficulty. Results and Observations: Most patients were young adults (19–30 years) and female (76%), presenting predominantly with right hypochondrial pain and dyspeptic symptoms. Imaging revealed gallbladder wall thickening, CBD stones, and inflammatory changes in select cases. A scoring system comprising 21 preoperative and 13 intraoperative parameters was developed, stratifying patients into three risk categories: Very Low (0–6), Low to Moderate (7–14), and Moderate to High (15–30). Higher scores correlated with increased surgical difficulty and conversion rates. Conclusion: Laparoscopic cholecystectomy remains the safest and most effective treatment for gallbladder disease. The proposed scoring system provides a simple and reliable tool to predict operative difficulty, allowing for better surgical planning, appropriate allocation of resources, and improved patient outcomes}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kishore_2025b, title = {A prospective study on independent risk factors for lower limb amputation in diabetic foot patients}, author = {T. Naga Raja Ravi Kishore and Satya Srividya Kalluri and Venugopal Sarveswaran}, url = {https://healthcare-bulletin.co.uk/article/a-prospective-study-on-independent-risk-factors-for-lower-limb-amputation-in-diabetic-foot-patients-4388/}, doi = {10.61336/ejcm/25-10-71}, issn = {2042-4884}, year = {2025}, date = {2025-10-22}, urldate = {2025-10-22}, journal = {European Journal of Cardiovascular Medicine}, volume = {15}, issue = {10}, pages = {405-411}, abstract = {Background: Diabetic foot remains one of the most serious complications of diabetes mellitus, often leading to infection, ulceration, gangrene, and limb amputation. It reflects a complex interaction between neuropathy, ischemia, and infection. Early identification of risk factors is essential for prevention and limb preservation. Aim of the study was to identify and quantify the independent risk factors associated with lower limb amputation among patients with diabetic foot disease. Materials and Methods: This prospective descriptive analytic study was conducted at the Department of General Surgery, Sri Ramakrishna Hospital, Coimbatore, from November 2014 to November 2016. A total of 150 diabetic foot patients aged 18–80 years were included. Clinical evaluation, laboratory investigations, Doppler ultrasonography, and culture studies were performed. Variables such as age, sex, duration of diabetes, HbA1C level, peripheral vascular disease (PVD), neuropathy, smoking, foot deformities, and comorbid illnesses were analyzed. Statistical analysis was done using SPSS version 17.0, with p < 0.05 considered significant. Results: Among the 150 patients, 98 (65.3%) were males and 52 (34.7%) females, with the majority in the 51–60-year age group. Neuropathy was observed in 40%, and ischemia in 35.3% of patients. Overall, 74 patients (49.3%) required amputation—24 (16%) major and 50 (33.3%) minor—while 76 (50.7%) were managed conservatively. Foot infections were present in 68.6%, with Pseudomonas (15.3%) and Staphylococcus aureus (12.7%) being the most common pathogens. Univariate analysis revealed smoking, PVD, neuropathy, higher PEDIS grade (>3), and associated comorbidities as significant predictors of amputation (p < 0.05), whereas duration of diabetes, HbA1C level, previous amputation, and foot deformities were not statistically significant. Conclusion: Neuropathy, ischemia, and infection remain the principal determinants of amputation in diabetic foot disease. Smoking and systemic comorbidities further increase the risk. Early detection, strict glycemic control, proper foot care, and a multidisciplinary approach are essential to prevent limb loss and improve outcomes in diabetic patients.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ali_2025b, title = {Rare meets routine: a case of sessile serrated lesion presenting as acute appendicitis}, author = {Syed Mubid Ali and Mohammed Abdullah Masood and Naushaba Tazeen and Asiya Tabassum and Idrees Akhtar Afroze and Atiya Begum and Shireen Adeeb Mujtaba Ali}, url = {https://ijpo.co.in/archive/volume/12/issue/3/article/24927/pdf}, doi = {10.18231/j.ijpo.11098.1680662831}, issn = {2394-6784}, year = {2025}, date = {2025-10-17}, urldate = {2025-10-17}, journal = {Indian Journal of Pathology and Oncology}, volume = {12}, issue = {3}, pages = {279-282}, abstract = {Sessile serrated lesions (SSLs) are rare premalignant neoplasms usually arising in the colon but can also occur in the appendix, where their presentation often mimics acute appendicitis. We report the case of a 68‑year‑old male who presented with right lower abdominal pain and imaging findings suggestive of acute appendicitis with appendicular mucocele. The patient underwent appendectomy, and histopathological examination of the resected specimen revealed a sessile serrated lesion with marked dysplasia, without evidence of adenocarcinoma. Appendiceal SSLs are seldom reported in literature and may be overlooked due to their nonspecific clinical and radiological features. As SSLs are important precursors of colorectal carcinoma via the serrated neoplasia pathway, meticulous histopathological evaluation is crucial for accurate diagnosis. Early recognition, surgical excision, and colonoscopic follow‑up can help prevent malignant transformation. This case adds to the limited literature on appendiceal SSLs and emphasizes the need for increased awareness and documentation.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Atharuddin_2025, title = {A comparative study of wound healing and complications with the use of 1-0 vicryl vs 1-0 prolene for rectus closure}, author = {Athar Mohammed Atharuddin and Neda Faraz and Arshiya Fatima}, url = {https://jccpractice.com/article/a-comparative-study-of-wound-healing-and-complications-with-the-use-of-1-0-vicryl-vs-1-0-prolene-for-rectus-closure-1458/}, doi = {10.61336/jccp/25-10-55}, issn = {2457-7200}, year = {2025}, date = {2025-10-15}, urldate = {2025-10-15}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {10}, pages = {372-380}, abstract = {Background: Surgery and sutures are inseparable. Down the ages, newer and more efficacious suture materials and techniques have been introduced. Among all wound closures, abdominal wound closure is the most challenging task for a surgeon. There are different techniques according to suture material, suturing technique and length of suture material that have been suggested optimal for rectus closure. These prospects are still under study and are controversial. This study was to compare the efficacy of vicryl and prolene for rectus closure by studying the wound healing and complication rates (wound infection, wound dehiscence, burst abdomen etc). Materials and Methods: The present prospective comparative study was conducted on patients admitted for surgeries in the Department of General surgery, Deccan College Of Medical Sciences, Hyderabad. for a period of 18 months. Prior to the initiation of the study, Ethical and Research Committee clearance was obtained from Institutional Ethical Committee. During present study total 50 patients meeting inclusion criteria were enrolled into the study. Results and observations: There was no statistical difference between the groups in terms of age (p: 0.1358); gender (p: 1.131); diabetic status (p: 1.1532); BMI (p: 1.1611); type of surgery (p: 0.8321); duration of surgery (p: 0.8321); intra operative hypotension prevalence (p: 0.1352); type of incisions (p: 1.3521); type of surgical site infections (p: 0.06). The incidence of burst abdomen (p: 0.01) was high in group B, day of burst abdomen incidence (p: 0.02), incidence of surgical site infections high in group B (p: 0.01); rate of wound healing was slow in group B (p: 0.001) Conclusion: From the present study we conclude that non-absorbable suture (prolene) was better in terms of wound healing and cosmesis as compared to absorbable suture used (vicryl) taking into consideration the points: wound dehiscence, burst abdomen incidence, surgical site infections incidence was higher in group B comparatively. Group B subjects had a slower rate of wound healing comparatively.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ayesha_2025c, title = {Assessment of hearing impairment in patients with allergic rhinitis through audiological profile}, author = {Syeda Ayesha and Waseem Ahmed and Khurram Adil Hashmi}, url = {https://www.ijmedph.org/Uploads/Volume15Issue3/391.%203001.%20IJMEDPH_Shubham%20Jaju_2118-2121.pdf}, doi = {10.70034/ijmedph.2025.3.391 }, issn = {2230-8598}, year = {2025}, date = {2025-09-30}, urldate = {2025-09-30}, journal = {International Journal of Medicine and Public Health}, volume = {15}, issue = {3}, pages = {2118-2121}, abstract = {Background: Allergic rhinitis (AR) is a common chronic inflammatory disorder affecting the upper respiratory tract, which may also impair auditory function through Eustachian tube dysfunction and middle ear involvement. Despite increasing awareness, its impact on hearing remains under-recognized. To assess the audiological profile of patients with allergic rhinitis using tympanometry and pure tone audiometry, and to explore the correlation between hearing thresholds and duration of AR symptoms. Materials and Methods: This cross-sectional, hospital-based study included 150 patients with clinically diagnosed allergic rhinitis and 150 age-matched controls. Audiological evaluation was conducted using the Titan Interacoustic Tympanometer and standard pure tone audiometry. Tympanogram types, air conduction thresholds, and degrees of hearing loss were compared. Pearson correlation was used to analyze the relationship between symptom duration and hearing thresholds. Results: AR patients had significantly more abnormal tympanograms (Type B: 20.7%, Type C: 10%) compared to controls (Type B: 3.3%, Type C: 4.7%) (p < 0.001). Air conduction thresholds were elevated across all frequencies in the AR group (p < 0.001), with a mean threshold of 30.5 ± 8.2 dB at 8000 Hz. Hearing loss was detected in 32% of AR patients—predominantly mild (22.7%) and moderate (6.7%). A moderate positive correlation (r = 0.41, p < 0.001) was found between duration of AR and hearing loss severity. Conclusion: Allergic rhinitis is significantly associated with subclinical conductive hearing loss and abnormal middle ear function, which worsen with prolonged symptom duration. Early audiological screening in AR patients is essential to prevent long-term auditory complications.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Idris_2025, title = {Eustachian valve endocarditis in patients with fournier’s gangrene and septic shock: a rare case and a literature review }, author = {Ahmed Sifeeldein Ahmed Idris and Umme Nashrah and Umme Amara and Nissar Shaikh}, url = {https://www.qscience.com/docserver/fulltext/qmj/2025/3/qmj.2025.93.pdf?expires=1759819401&id=id&accname=guest&checksum=1C92FB251CA567B82A4BCC00C75DACF1}, doi = {10.5339/qmj.2025.93}, issn = {0253-8253}, year = {2025}, date = {2025-09-15}, urldate = {2025-09-15}, journal = {Qatar Medical Journal}, volume = {2025}, issue = {3}, pages = {93}, abstract = {Introduction: The eustachian valve (EV) is a remnant of the right sinus venosus valve. It remains different in size and shape without much impact on adult life. In 5% to 10% of all endocarditis, are seen in the right side of the heart is involved, which is rare compared to the left side of the heart. Bacteremia, central venous catheter, heart implants, and drug abuse increase the risk of EV vegetation and right heart endocarditis. We are reporting a case of EV endocarditis in patients with Fournier’s gangrene and septic shock. Case Presentation: A 45-year-old male patient was admitted into the surgical intensive care unit with Fournier’s gangrene, septic shock, and acute kidney injury (AKI). The patient was managed by invasive ventilation, noradrenaline, vasopressin, and renal replacement therapy. He developed Escherichia coli bacteremia and candidemia. We added meropenem and antifungal to the therapy. The transthoracic echocardiography showed EV vegetation and thread-like vegetation in the right coronary sinus, which was confirmed with transesophageal echocardiography. With aggressive therapies, the patient recovered from septic shock, organ dysfunction and was successfully liberated from invasive ventilation. The patient was discharged home on day 27. The antibiotics and antifungal were continued for 6 weeks. Two weeks after discharge, the follow-up echocardiogram was normal, and he was doing well. Discussion: Eustachian valve endocarditis is rare, and should be treated with appropriate, culture- and sensitivity-guided antibiotics and or antifungal therapy for 6 weeks. The outcome of EV vegetations of endocarditis is good. The reported mortality is up to 17%. The independent risk factors associated with mortality are AKI, the Charlson comorbidity index, congestive heart failure, larger vegetation, and central nervous system involvement. Conclusion: The presence of larger EV, along with E. coli (ESBL) bacteremia and fungemia, increases the risk of right-sided endocarditis, which is rarely reported. Our patient was diagnosed early, received appropriate antimicrobial treatment for a sufficient duration, resulting in a better outcome. A high index of suspicion, along with early diagnosis and culture-guided 6-week antimicrobial therapy, will improve the patient’s outcomes.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025e, title = {Humoral immune response to COVID-19 vaccine in health care workers and the factors influencing it during vaccine drive - a cross-sectional study}, author = {Sarwat Fatima and Deepika Handa}, url = {https://ijmmtd.org/archive/volume/11/issue/3/article/24512/pdf}, doi = {10.18231/j.ijmmtd.v.11.i.3.15 }, issn = {2581-4753}, year = {2025}, date = {2025-09-04}, urldate = {2025-09-04}, journal = {IP International Journal of Medical Microbiology and Tropical Diseases}, volume = {11}, issue = {3}, pages = {323-329}, abstract = {Background: The COVID-19 vaccine drive by the public healthcare system had several safety and efficacy concerns in the minds of health care workers and common man for several vague reasons. Objective: In this context; the study was planned to determine the humoral immune response in the vaccine recipients of the first indigenously prepared vaccines in India [Covaxin & Covishield]. And, to know the influence of various factors on it. Lastly, to note the adverse events reported by the recipients if any. Materials and Methods: A cross-sectional point prevalence study with simple convenient sampling method was designed. Baseline data on demographics, presence of comorbid conditions, vaccination details, adverse events to vaccine and information on presence of COVID-19 disease in the past 3-6 months was obtained from participants using a validated questionnaire. Institutional ethical clearance was obtained. The participants’ inclusion and exclusion criteria were established. SARS-CoV-2 IgG antibody was determined using ELFA method. Antibody index was estimated and used for interpretation of the test results. Statistical R software was used for data analysis. Results: of the 86 participants, 84 were found eligible for enrollment. Male to female ratio was 0.9:1. The study participants were in the age group from 20-80 years. Around 29/84[34.52%] had comorbid conditions and the commonest comorbid conditions was hypertension. Overall, 72/84 [86%] of the HCWs were seropositive following vaccination. Greater number of fully vaccinated HCWs 60/62 [97%] were seropositive than partially vaccinated 12/22 [54%] with a p value of 0.001 and their corresponding antibody index was also higher. Among the various variables studied age, gender and presence of comorbid conditions the last one had a positive impact on seropositivity and antibody index values. Mild adverse events following vaccination were noted in majority. However, the antibody index was higher for them than in participants with no adverse events. Conclusion: Our study highlights the efficacy and safety of vaccine by demonstrating seroconversion in 86% of the recipients and clears the vaccine hesitancy from the minds of HCWs and common man as well.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Singhal_2025, title = {A narrative review on fecal microbiota transplantation routes in ulcerative colitis: identifying the optimal approach across key parameters}, author = {Rohan Singhal and Gayatri Ghadvaje and Nanditha Karra and Sai Teja Gadde and Prerna Chandra and Bharat Krishna Teja Voruganti and Navya Pillikunte Doddareddy and Sadaf Iftikhar and Tirath Patel}, url = {https://journals.lww.com/annals-of-medicine-and-surgery/abstract/9900/a_narrative_review_on_fecal_microbiota.3380.aspx}, doi = {10.1097/ms9.0000000000003841}, issn = {2049-0801}, year = {2025}, date = {2025-09-02}, urldate = {2025-09-02}, journal = {Annals of Medicine & Surgery}, abstract = {Fecal microbiota transplantation (FMT) has gained increasing attention as a novel therapeutic approach for treating ulcerative colitis (UC), a chronic inflammatory bowel disease that causes an imbalance in the gut microbiota. Although FMT has demonstrated the potential to induce remission in UC patients, the most effective route of administration remains an area of active investigation. This narrative review provides a comprehensive comparison of different FMT delivery methods, such as oral capsules, enemas, colonoscopy, and nasogastric or nasoenteric tubes, across a range of clinically relevant parameters, including efficacy, safety, patient satisfaction, microbiota changes, pretreatment protocols, and cost-effectiveness. Furthermore, we examined how post-FMT dietary interventions may influence microbial engraftment and improve the long-term outcomes in patients with UC. In addition to assessing these practical and clinical factors, this review highlights the importance of patient-centered considerations, such as the tolerability and convenience of each administration route. The integration of these findings can provide valuable insights into how different FMT routes affect disease outcomes and guide clinicians in optimizing the treatment for individual patients. By synthesizing current evidence on these key variables, we aimed to identify the most effective and feasible FMT approach for UC. Establishing standardized protocols for FMT administration, informed by this analysis, will be crucial for ensuring consistency in clinical practice, improving patient outcomes, and minimizing adverse events. The insights from this review will help pave the way for more targeted and individualized FMT strategies, ultimately enhancing the therapeutic landscape of UC management.}, note = {Ahead of print}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Chaudhry_2025, title = {Fetal-maternal complications due to pregnancy-acquired tuberculosis: a narrative review of the literature}, author = {Waleed Razzaq Chaudhry and Sana Altaf and Cara Mohammed and Sofia Fuerte}, url = {https://www.monaldi-archives.org/macd/article/view/3126/2125}, doi = {10.4081/monaldi.2025.3126}, issn = {1122-0643}, year = {2025}, date = {2025-09-01}, urldate = {2025-09-01}, journal = {Monaldi Archives for Chest Disease}, abstract = {Tuberculosis (TB) during pregnancy can cause certain deleterious effects to both the mother and the fetus, leading to significant morbidity and mortality. The risk of TB rises significantly during pregnancy due to dampening of the immune response in females and certain factors yet to be studied. Since pregnant females are ruled out of clinical trials due to their pregnancy status, not much clinical data is available on how to combat TB in them or about the clinical safety and efficacy of certain drugs. Hence, not only is it important to make pregnant females vital study participants of clinical trials, but also to enhance their knowledge regarding the disease so that they may timely access quality care. It is also important to facilitate these TB-positive pregnant females through the introduction of gender-sensitive policies that are more exclusive and allow access to quality TB control programs that provide timely care, nutritional support, and quality and supportive management.}, note = {Online ahead of print}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2025, title = {Correlation of comorbidities and outcome in CAD patients: a novel TANGENTS score study}, author = {Mohammed Abdul Hannan Hazari and Kailas Laxman Rao and Bachi Tazneem and Sana Rafeeq and Syeda Rahmath Fatima and Summaya Jabeen and Kankan Kavya}, url = {https://mmsl.cz/artkey/mms-202503-0002_correlation-of-comorbidities-and-outcome-in-cad-patients-a-novel-tangents-score-study.php}, doi = {10.31482/mmsl.2024.009}, issn = {0372-7025}, year = {2025}, date = {2025-09-01}, urldate = {2024-06-18}, journal = {Military Medical Science Letters}, volume = {94}, issue = {3}, pages = {107-114}, publisher = {Faculty of Military Health Sciences, University of Defence, Czech Republic}, abstract = {Background: Cardiovascular diseases (CVD) are influenced by various established risk factors, including the ratio of neutrophils to lymphocytes and platelets, which has been shown to be an independent risk factor for acute coronary syndrome (ACS). This study aims to create a new scoring system called TANGENTS that utilizes discrete parameters of risk factors and diagnostic parameters to analyze the outcome of coronary artery disease (CAD) patients with comorbidities, particularly Type 2 diabetes mellitus (T2DM). Methods: We included 151 subjects (mean age 57.92 ± 23.86) who presented with ST-elevation and ST-depression on admission and were treated with heparin, clopidogrel, aspirin, and atorvastatin while undergoing all the necessary diagnostic tests. We obtained ECG and complete blood picture (CBP) results on admission, day 3, and day of discharge. Results: ST-depression on ECG on day-1 was 0.35 and decreased to 0.30 on the day of discharge. ST-elevation on ECG on day-1 was -0.89 and decreased to -0.16 on the day of discharge. The average neutrophil-to-lymphocyte ratio (NPR) was 0.49, which was high in 144 patients. The mean NLR value was 5.52, indicating a correlation between high NLR values and the magnitude of current injury on admission. Conclusion: The TANGENTS scoring system can be used as an early evaluation tool for CAD patients with comorbidities to manage and prevent further complications. It allows for progressive differentiation in the severity of clinical outcomes using all the parameters of the score, and the parameters creating the TANGENTS score scale were found to be reliable.}, keywords = {Cardiology, Deccan School of Pharmacy, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025h, title = {Anticoagulant initiation after cardioembolic stroke: practical timing and options}, author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/14185/8653}, doi = {10.18203/2394-6040.ijcmph20252872}, issn = {2394-6032}, year = {2025}, date = {2025-08-30}, urldate = {2025-08-30}, journal = {International Journal of Community Medicine and Public Health}, volume = {12}, issue = {9}, pages = {4186-4195}, abstract = {Cardioembolic Stroke (CES) is a leading cause of Acute Ischemic Stroke (AIS) and is linked to worse outcomes. There is a notably increased risk of “hemorrhagic transformation” (HT) in CES cases, where anticoagulant therapy is essential for patients with atrial fibrillation (AF) to prevent future strokes. Additionally, larger infarcts are associated with a higher risk of HT, effectively doubling the mortality risk. Currently, there are no clear guidelines connecting infarct size to “anticoagulation” decisions or management of HT cases. This review specifically focuses on the timing of “anticoagulation” initiation in patients with AF. Out of 380 articles evaluated, 50 relevant studies were included in this review. Generally, existing guidelines recommend starting “anticoagulation” between 4 to 14 days after anAIS. The review seeks to summarize current research on early versus late “anticoagulation” initiation in AF patients who experience AIS, providing clinicians with practical insights on optimal timing and the selection of effective and safe anticoagulants.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Faraz_2025, title = {Role of c-reactive protein, serum amylase and apache II scoring system in predicting the severity of acute pancreatitis}, author = {Neda Faraz and Mohammed Abdul Hadi and Ameer Khan}, url = {https://jccpractice.com/article/role-of-c-reactive-protein-serum-amylase-and-apache-ii-scoring-system-in-predicting-the-severity-of-acute-pancreatitis-1219/}, doi = {10.61336/jccp/25-08-102 }, issn = {2457-7200}, year = {2025}, date = {2025-08-25}, urldate = {2025-08-25}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {8}, pages = {761-766}, abstract = {Background: Acute pancreatitis is a catastrophic condition with many complications and poses a great challenge to the treating surgeon. 1020% of the patients who develop complications will not recover with simple supportive therapy. Hence, an accurate prediction of severity and prognostic monitoring are necessary to anticipate the early and late complications so as to consider aggressive treatment. The present study aimed at predicting the prognosis in patients with acute pancreatitis by using the serum AMYLASE, serum LIPASE, APACHE II scoring system and at determining the utility of these scores in further management. Methods and Material: 84 patients, who were admitted to the PES Institute of Medical sciences with the clinical and radiological evidence of acute pancreatitis with an elevation in the serum amylase levels, were the subjects of this study. Results: Among 84 patients, 50 had severe disease and 34 had mild disease based on serum CRP (P<0.05).On the first day of hospitalisation Serum amylase and APACHE II scoring system were analysed. Serum CRP taken at 48 hours of admission. The age of incidence is often between 31 to 40 years. Males are more commonly affected than females. Alcohol was the main factor in both mild and severe disease-related deaths. The upper limit in this study for serum amylase were 1000U/L, APACHE II score >8 and serum CRP >150mg/L. The percentile of patients for mild and severe pancreatitis for serum amylase, APACHE II score and serum CRP includes 83.3%, 45.2%, 40.5% and 16.7%, 54.8%, 59.5%. The standard deviation of serum amylase, APACHE II score and serum CRP includes 347.1,3.0, 24.1.The statistical inference of all the three parameters comparing one value with other parameters shows serum CRP has significant value of P<0.05. Conclusion: Serum CRP plays a significant role in stratifying individuals for early, aggressive treatment in order to reduce morbidity and mortality from acute pancreatitis. To define characteristics that allow for the establishment of multifactorial scores or biomarkers to predict acute pancreatitis severity and track disease progression, large population-based multi centre studies must be designed and conducted.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Tague_2025, title = {Exploring the national burden and challenges in the fight against yellow fever in the Democratic Republic of Congo. A review}, author = {Christian Tague and Mayar Moustafa Budair and Maher Ali Rusho and Areeba Aamir Ali Basaria and Rabeea Tariq and Hermann Yokolo and Joshua Ekouo and Farheen Naaz and Dujardin Makeda and Adolphe Karegeya and Mc Juan Muco Mugisha and Calvin R. Wei}, url = {https://journals.lww.com/annals-of-medicine-and-surgery/abstract/9900/exploring_the_national_burden_and_challenges_in.3295.aspx}, doi = {10.1097/ms9.0000000000003730}, issn = {2049-0801}, year = {2025}, date = {2025-08-19}, urldate = {2025-08-19}, journal = { Annals of Medicine & Surgery}, abstract = {The Democratic Republic of Congo (DR Congo) is facing a public health emergency due to numerous infectious diseases, predominately yellow fever. Since 2015, numerous outbreaks of the illness have occurred in the country which resulted in detrimental impacts on the population. As of February 2024, the DR Congo has reported over 1,200 suspected yellow fever cases with an 11% case fatality rate. This represents a 22% increase compared to 2021 when 203 confirmed cases were reported with a 9% fatality rate. Although there is no specific medication to treat yellow fever, vaccination is proven to be the most effective method of prevention. Despite national and international efforts to combat the disease through vaccination campaigns, yellow fever continues to pose a significant threat. This is because vaccination efforts are limited by the inadequate infrastructure, poverty, poor sanitation and the presence of rebel groups in the DR Congo. Early diagnosis, the use of mosquito nets and insecticides, as well as raising awareness can furthermore aid in limiting transmission. This review explores the prevalence, diagnosis and prevention methods of yellow fever in the DR Congo, as well as the numerous obstacles faced by the country to eliminate it.}, note = {Online ahead of print}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Alali_2025, title = {From air embolism to acute respiratory distress syndrome: a rare complication in a posterior fossa tumour excision-a case report}, author = {Jawdat M. Alali and Umme Amara and Umme Nashrah and Firdous E. Ummunnisa and Mahmoud Tabouni and Nissar M. Shaikh }, url = {https://www.sciencedirect.com/science/article/pii/S2210261225010223?via%3Dihub}, doi = {10.1016/j.ijscr.2025.111836}, issn = {2210-2612}, year = {2025}, date = {2025-08-18}, urldate = {2025-08-18}, journal = {International Journal of Surgery Case Reports}, volume = {135}, pages = {111836}, abstract = {No abstract available}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Naaz_2025, title = {Prognostic value of plasma lysophosphatidic acid and CD62P in the outcome of ischemic stroke }, author = {Sabeeha Naaz and Swarna Anupama and Thrilok Chander Bingi}, url = {https://journals.lww.com/annalsofian/abstract/9900/prognostic_value_of_plasma_lysophosphatidic_acid.453.aspx}, doi = {10.4103/aian.aian_83_25}, year = {2025}, date = {2025-08-13}, urldate = {2025-08-13}, journal = {Annals of Indian Academy of Neurology}, number = {pmid40802465}, pages = {1-6}, abstract = {Background and objectives: Stroke is the second leading cause of death worldwide, and only 10% of the patients can live their normal lives. As per the Global Burden of Disease Study 2016, the incidence of stroke in India is reported to be 1,175,778 (1 076 048 to 1,274,427) per 100000 person-years. A novel biochemical marker that can predict the stroke outcome can reduce morbidity, especially when thrombolysis cannot be done. Hence, the current study aims to study the role of plasma lysophosphatidic acid (LPA) and CD62P as prognostic markers for acute ischemic stroke. Methods: This is a prospective observational study. Ninety-six patients who met the inclusion criteria were enrolled. The plasma LPA and CD62P levels were estimated using the enzyme-linked immunosorbent assay and correlated with the Alberta stroke program early computed tomography score (ASPECTS) on CT brain and modified Rankin scale (mRS) at 90 days. Results: Age, sex, and other risk factors in the ischemic stroke patients did not have any impact on the levels of LPA and CD62P. Both LPA (P = 0.000) and CD62P (P = 0.005) showed a positive correlation with mRS after 90 days. The mean LPA was highest for mRS 5 and least for mRS 1, whereas the mean CD62P levels did not correlate with increasing mRS. The ASPECTS showed a significant negative correlation only with LPA. Conclusions: High LPS and CD62P levels after stroke onset tend to be associated with poor mRS scores at 90 days.}, note = {Online ahead of print}, keywords = {Medical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Begum_2025, title = {A comprehensive review on orthopedic pain}, author = {Syeda Zuleqaunnisa Begum and Saritha Chukka and Mohammed Akram}, url = {https://www.rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2025-18-8-69}, doi = {10.52711/0974-360X.2025.00566}, issn = {0974-360X}, year = {2025}, date = {2025-08-02}, urldate = {2025-08-02}, journal = {Research Journal of Pharmacy and Technology}, volume = {18}, issue = {8}, pages = {3939-3944}, abstract = {Orthopedic pain management is complex and challenging in healthcare due to its characteristics, causes and frequency of recovery. Nociceptive and Neuropathic pain pathway are the underlying mechanism involved with numerous symptoms aching, stiffness, burning sensations, pain worsening with movement, severe bruising, inflammation, cramping, localized tenderness. Unidimensional scale, multidimensional scale and postoperative pain measurement techniques are used to assess the appropriate pain intensity and relief. Pharmacological management involves a combination of non-opioid analgesics, opioids, adjuvant agents, and emerging therapies, with a focus on multimodal analgesia to enhance pain relief and minimize opioid use. The review also highlights challenges in managing orthopedic pain, including diagnostic complexity, imaging limitations, the need for individualized treatment plans and psychological and social factors. Pain should be considered during preoperative, intraoperative, postoperative and at the time of discharge. Effective pain management requires constant reassessment with individualized treatment regimen. Major efforts should be taken by the healthcare professional and patients during the postoperative pain period as it involves the healing period associated with several risk factors like hospital discharge, severity of surgery, physiotherapy mobilization. Implementation of multimodal pain management along with physiotherapy, exercise and patients counselling are effective for reducing postoperative pain.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Moinuddin_2025, title = {Unexplained hypoglycemia in a diabetic patient unveiling insulinoma: a case report}, author = {Mohammed Faris Razi Moinuddin and Aasiya Shahbaz Sakarwala and Noor Ul Ain Shahzad and Waleed Ahmad}, url = {https://innovapath.us/index.php/IN/article/view/74/63}, doi = {10.63501/7xvwd239}, issn = {3067-8102}, year = {2025}, date = {2025-07-31}, urldate = {2025-07-31}, journal = {INNOVAPATH:Journal of Translational Medicine & Biotechnology}, volume = {1}, issue = {6}, pages = {5}, abstract = {Background: Insulinomas are rare, typically benign, insulin-secreting neuroendocrine tumors with an incidence of 1–4 cases per million annually. They commonly present with Whipple’s triad: symptoms of hypoglycemia, low plasma glucose, and resolution of symptoms with glucose administration. The coexistence of insulinoma with type 2 diabetes mellitus (T2DM) is extremely uncommon and often results in diagnostic delays due to overlapping clinical features and misattribution of hypoglycemia to antidiabetic therapy. Case Presentation: We describe the case of a 65-year-old obese woman with a 16-year history of T2DM and hypertension, who presented with persistent symptomatic hypoglycemia despite discontinuation of insulin therapy. Her HbA1c ranged between 5.7% and 8.4% over the past year, and she was previously managed with 40 units/day of premixed insulin. Hypoglycemic episodes continued after insulin cessation, prompting inpatient evaluation. During hospitalization, she exhibited documented plasma glucose of 33 mg/dL with concurrent inappropriately elevated insulin (74.4 µIU/mL) and C-peptide (8.5 ng/mL) levels, confirming endogenous hyperinsulinemia. Chromogranin A was markedly elevated (350 ng/mL). Imaging via contrast-enhanced CT revealed a 14-mm hypervascular lesion in the pancreatic tail. The patient underwent successful laparoscopic distal pancreatectomy. Histopathology confirmed a 17-mm, well-differentiated, grade 3 pancreatic neuroendocrine tumor, positive for chromogranin and synaptophysin. Postoperatively, she developed persistent hyperglycemia requiring resumption of premixed insulin at 0.6 U/kg/day. At 3-month follow-up, she remained insulin-dependent but was free of further hypoglycemic episodes. Discussion: This case underscores the diagnostic complexity when insulinoma coexists with long-standing T2DM. In patients with continued hypoglycemia after insulin withdrawal, endogenous causes such as insulinoma must be considered. High clinical suspicion, biochemical profiling during hypoglycemic episodes, and timely imaging are essential. Notably, this case involved a well-differentiated grade 3 tumor; an uncommon histological finding in insulinomas which may have implications for surveillance due to its potential for more aggressive behavior. The persistence of diabetes post-resection highlights the ongoing insulin resistance associated with long-standing T2DM, despite tumor removal. Conclusion: Insulinoma should remain a differential in diabetic patients presenting with unexplained or worsening hypoglycemia, particularly after insulin discontinuation. Early diagnosis, appropriate imaging, and surgical resection are crucial for favorable outcomes. Postoperative metabolic monitoring remains essential due to the dual risk of hyperglycemia and hypoglycemia.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2025d, title = {A review delving through current challenges in AMR and using artificial intelligence in dealing with AMR}, author = {Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/sbvj/fulltext/2025/07000/a_review_delving_through_current_challenges_in_amr.12.aspx}, doi = {10.4103/sbvj.sbvj_39_25}, issn = {2581-6039}, year = {2025}, date = {2025-07-31}, urldate = {2025-07-01}, journal = {SBV Journal of Basic, Clinical and Applied Health Science}, volume = {8}, issue = {3}, pages = {155–158}, publisher = {Wolters Kluwer Health}, abstract = {Antimicrobial resistance in pathogenic microorganisms is being accelerated by the overuse of antibiotics, which is a major global public health concern. Severe infections, serious complications, longer hospital stays, and even higher death rates are all brought on by increasing resistance. National economies and health systems are greatly impacted by antimicrobial resistant (AMR), which reduces patient or caregiver productivity by causing extended hospital stays that are expensive. While conventional methods of addressing antimicrobial resistance (AMR) are costly and time-consuming, artificial intelligence (AI) is currently being developed to quickly search through large chemical libraries and predict potential antibacterial compounds. Using AI, scientists may quickly find possible new medications that might work against germs resistant to antibiotics, which might save a significant amount of time throughout the development process. AI algorithms that analyse enormous volumes of data can also assist in forecasting future patterns in antibiotic resistance, enabling preventative actions. In the continuous fight against antibiotic resistance, the use of AI in medical research appears to have a lot of promise. In addition to discussing AMR, this review explains how AI is being used in AMR markers to help manage AMR.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Quadri_2025, title = {Menstrual health practices in women with severe psychiatric disorders}, author = {Syeda Kulsoom Quadri and Mohammed Abdur Rahman and Mariyah Amjad and Zohra Fatima S. and Syed Shah Ali Hussain Razvi and Mohd. Amrullah and Syeda Ayesha Siddiqua}, url = {https://www.msjonline.org/index.php/ijrms/article/view/15094/9775}, doi = {10.18203/2320-6012.ijrms20252388}, issn = {2320-6012}, year = {2025}, date = {2025-07-30}, urldate = {2025-07-30}, journal = {International Journal of Research in Medical Sciences}, volume = {13}, issue = {8}, pages = {3228-3232}, abstract = {Background: Menstrual hygiene constitutes an essential facet of women's health and dignity. Women diagnosed with severe mental illness frequently encounter obstacles in the maintenance of personal hygiene attributable to cognitive impairments, deficits in self-awareness and reliance on caregivers. Notwithstanding its critical importance, menstrual hygiene continues to be an overlooked dimension of mental health care for this demographic. To assess and compare menstrual hygiene practices among females with severe mental illness and healthy age-matched caregivers using the Menstrual Practice Needs Scale (MPNS-36). Methods: This cross-sectional, comparative study was conducted at the Department of Psychiatry at Shadan Institute of Medical Sciences, Telangana. A total of 80 participants were recruited through consecutive sampling 40 clinically stable female patients diagnosed with schizophrenia, bipolar affective disorder or obsessive-compulsive disorder and 40 healthy female caregivers as controls. Sociodemographic and clinical details were collected using structured proformas. Menstrual hygiene practices were assessed using the MPNS-36. Data were analyzed using SPSS (22.0) and a p value of <0.05* was considered statistically significant. Results: The mean age of patients and caregivers was 34.59±5.09 years and 31.14±6.33 years, respectively. Statistically significant differences were observed in domains related to comfort with menstrual materials, adequacy of supplies and worry about running out of materials. Other domains showed no significant intergroup differences. Conclusions: Women diagnosed with severe mental illnesses exhibited both equivalent and inadequate menstrual hygiene practices in comparison to healthy control subjects. The incorporation of menstrual hygiene education within psychiatric rehabilitation programs is imperative for fostering comprehensive care.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mujahid_2025b, title = {Perioperative cognitive dysfunction in patients undergoing ENT surgeries: role of depth of anaesthesia monitoring (BIS) and dexmedetomidine infusion}, author = {Mohammed Naseeruddin Mujahid and Maroof Ahmed Choudhary and Naseeba Fatima}, url = {https://www.jptcp.com/index.php/jptcp/article/view/11300/10537}, doi = {10.53555/mea15931}, issn = {2561-8741}, year = {2025}, date = {2025-07-23}, urldate = {2025-07-23}, journal = {Journal of Population Therapeutics and Clinical Pharmacology}, volume = {32}, issue = {7}, pages = {1174-1178}, abstract = {Perioperative cognitive dysfunction (POCD) is a common complication following surgery, particularly in elderly patients, resulting in memory impairment, attention deficits, and decreased executive function. Factors such as anaesthetic depth and intraoperative medication usage are known to contribute to the pathogenesis of POCD. The Bispectral Index (BIS), a measure of anaesthetic depth, and Dexmedetomidine, an alpha-2 adrenergic receptor agonist with neuroprotective effects, have both been suggested as methods to reduce POCD incidence. Aim of the Study: This study aimed to evaluate the role of BIS-guided anaesthesia and Dexmedetomidine infusion in reducing the incidence and severity of POCD in elderly patients undergoing elective ENT surgeries. Objectives: To compare the effects of BIS-guided anaesthesia with and without Dexmedetomidine infusion on cognitive function post-surgery and to analyze intraoperative anaesthetic requirements and haemodynamic stability. Materials and Methods: A total of 120 patients aged 60 years and above, undergoing elective ENT surgeries under general anaesthesia, were randomly assigned to three groups: Group A (standard anaesthesia), Group B (BIS-guided anaesthesia), and Group C (BIS-guided anaesthesia with Dexmedetomidine). Cognitive function was assessed using the Mini-Mental State Examination (MMSE), Digit Symbol Substitution Test (DSST), and Trail Making Test (TMT) at baseline, postoperatively on day 3, and at 1-month follow-up. Statistical analysis was performed using SPSS. Results: The incidence of POCD was significantly lower in Group C (2.5%) compared to Group A (15%) and Group B (7.5%) at the 1-month follow-up (p < 0.05). Group C also showed superior cognitive outcomes in MMSE, DSST, and TMT scores. Intraoperative hemodynamic stability was better in Group C, with fewer hypotensive episodes and reduced anaesthetic consumption compared to the other groups. Conclusions: The study demonstrates that BIS-guided anaesthesia combined with Dexmedetomidine infusion significantly reduces the incidence and severity of POCD in elderly patients undergoing ENT surgery. These findings suggest that optimizing anaesthetic depth and incorporating Dexmedetomidine may offer neuroprotective benefits, improving cognitive outcomes in this vulnerable population.}, keywords = {Anesthesiology, Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Akilimali_2025, title = {Addressing the malaria crisis among children in Uganda: the urgent need for vaccination and strategic action}, author = {Aymar Akilimali and Christian Tague and Adolphe Karegeya and Nathan Mugenyi and Javeria Taj and Innocent Mufungizi and Farheen Naaz and Mc Juan Muco Mugisha and Hugues Cakirwa}, url = {https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2025/08000/addressing_the_malaria_crisis_among_children_in.97.aspx}, doi = {10.1097/MS9.0000000000003537}, issn = {2049-0801}, year = {2025}, date = {2025-07-16}, urldate = {2025-07-16}, journal = {Annals of Medicine & Surgery}, volume = {87}, issue = {8}, pages = {5344-5346}, abstract = {No abstract available}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Alali_2025b, title = {Postoperative vision loss following bariatric surgery: case report and literature review}, author = {Jawdat M. Alali and Umme Amara and Mahmoud Tabouni and Umme Nashrah and Nissar Shaikh}, url = {https://assets.cureus.com/uploads/case_report/pdf/382158/20250814-82015-mudpc8.pdf}, doi = {10.7759/cureus.87995}, issn = {2168-8184}, year = {2025}, date = {2025-07-15}, urldate = {2025-07-15}, journal = {Cureus}, volume = {17}, issue = {7}, pages = {e87995}, abstract = {Postoperative blindness following non-ophthalmic surgeries is a rare but devastating complication, most commonly associated with spine and cardiovascular procedures. Thus far, there have been no reports of total blindness after metabolic surgeries in the literature. We present a case of transient total vision loss after laparoscopic sleeve gastrectomy in a young obese female patient with poorly controlled type 2 diabetes mellitus and hypertension on antihypertensive agent. Following induction of general anesthesia, the patient experienced severe hypertensive episodes lasting approximately five minutes, although the remainder of the intraoperative course was uneventful. She was transferred to the surgical intensive care unit (SICU) for postoperative monitoring. 30 minutes later, she reported sudden complete blindness while remaining hemodynamically stable and alert. During transfer for neuroimaging, she developed a generalized seizure and a decreased Glasgow Coma Scale (GCS) score, necessitating endotracheal intubation and mechanical ventilation. Brain CT and MRI findings were consistent with posterior reversible encephalopathy syndrome (PRES). Although her GCS improved within 24 hours, visual impairment persisted until gradual recovery commenced on the second postoperative day, with full restoration by day three. The patient was subsequently transferred to the ward and later discharged with close outpatient follow-up. This case highlights PRES as a rare cause of perioperative vision loss and underscores the critical importance of rigorous blood pressure management in the perioperative period to mitigate neurological complications.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Zamani_2025, title = {Recommendations for addressing suicidal ideation precipitated by levetiracetam in the treatment of seizure disorder: a case report and review of the literature}, author = {Ishrath Zamani and Misha Khalid Khan and Ann Manzardo and Naveen Khanzada}, url = {https://assets.cureus.com/uploads/case_report/pdf/244842/20250813-148574-mq7kv7.pdf}, doi = {10.7759/cureus.87919}, issn = {2168-8184}, year = {2025}, date = {2025-07-14}, urldate = {2025-07-14}, journal = {Cureus}, volume = {17}, issue = {7}, pages = {e87919}, abstract = {Suicidal ideation with levetiracetam is a relatively common occurrence in psychiatry and neurology practices. However, there are no established treatment guidelines, and more empirical evidence is needed to guide medical management in these cases. This report describes the case of a 17-year-old male patient with a history of poorly controlled epilepsy on oxcarbazepine who developed worsening anxiety after the initiation of levetiracetam and presented with suicidal ideation for the past three weeks; this was effectively managed with comprehensive care in our inpatient psychiatric center, resulting in the resolution of these thoughts. To support this case, we conducted a literature review using MEDLINE (Medical Literature Analysis and Retrieval System Online), PubMed, and Google Scholar to explore existing treatment protocols for patients experiencing suicidal ideation related to levetiracetam. This study proposes a treatment protocol, presented as a flowchart, that outlines various treatment modalities based on assessed risk factors in patients with suicidality associated with levetiracetam. We conclude that establishing a psychiatric treatment protocol will enable providers to effectively manage an amenable risk factor of suicidality. There is a need for further evidence-based research studies to strengthen our proposed treatment protocol.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mujahid_2025, title = {Prescription patterns and patient acceptance of intranasal corticosteroids in seasonal allergic rhinitis: a cross-sectional study in an urban population}, author = {Mohammed Naseeruddin Mujahid and Syeda Ayesha and Waseem Ahmed}, url = {https://jptcp.com/index.php/jptcp/article/view/10630/9901}, doi = {10.53555/3m12sh42 }, issn = {2561-8741}, year = {2025}, date = {2025-07-02}, urldate = {2025-07-02}, journal = {Journal of Population Therapeutics and Clinical Pharmacology}, volume = {32}, issue = {5}, pages = {1534-1541}, abstract = {Background: Seasonal allergic rhinitis (SAR) is a prevalent immunoglobulin E–mediated inflammatory condition of the nasal mucosa, characterized by sneezing, nasal congestion, rhinorrhea, and itching. Intranasal corticosteroids (INCS) are the mainstay of pharmacotherapy due to their superior efficacy and safety profile. However, real-world adherence to prescribed INCS therapy remains suboptimal, particularly in urban populations, where socio-cultural perceptions, health literacy, and physician-patient interactions may influence treatment acceptance. Aim and Objectives: To evaluate the prescription patterns of steroid nasal sprays among patients diagnosed with SAR in urban clinical settings and to identify the factors influencing their acceptance and continued use. Materials: A cross-sectional observational study was conducted over six months in ENT and general outpatient departments of urban tertiary care hospitals. Patients aged 18–60 years diagnosed with SAR and prescribed INCS were enrolled after informed consent. A structured questionnaire captured demographic data, prescription details, patient-reported adherence, and perception-based factors influencing usage. Descriptive statistics, chi-square tests, and logistic regression were applied to identify significant determinants of acceptance and adherence. Results: Among 300 SAR patients enrolled, 212 (70.6%) were prescribed INCS as first-line therapy. Fluticasone and Mometasone were the most commonly prescribed agents. Only 148 patients (69.8%) adhered to therapy beyond two weeks. Key reasons for non-adherence included fear of dependency (34.1%), perceived lack of immediate relief (27.8%), cost concerns (15.2%), and lack of counselling (22.9%). Acceptance was significantly associated with higher education (p<0.01), previous use of INCS (p<0.05), and detailed physician explanation at the time of prescription (p<0.001). Logistic regression revealed that physician counselling and prior awareness of SAR significantly predicted continued INCS use (Adjusted OR: 3.45; 95% CI: 1.92–6.18). Conclusion: Despite being clinically recommended, the real-world acceptance of INCS in urban SAR patients is hampered by misperceptions, inadequate counselling, and affordability issues. Strengthening patient education, reinforcing the safety profile of INCS, and incorporating behavioural support strategies into prescription practices may improve treatment adherence and clinical outcomes.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Tague_2025b, title = {Leprosy in the Democratic Republic of the Congo: a persistent but neglected disease – current trends, challenges and future prospects}, author = {Christian Tague and Hermann Yokolo and Joshua Ekouo and Dujardin Makeda and Nathan Mugenyi and Shahar Mbbs Bano and Gbènonminvo Enoch Cakpo and Farheen Naaz and Alimasi Kashafali and Elie Kihanduka}, url = {https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2025/08000/leprosy_in_the_democratic_republic_of_the_congo__a.8.aspx}, doi = {10.1097/ms9.0000000000003540}, issn = {2049-0801}, year = {2025}, date = {2025-07-02}, urldate = {2025-07-02}, journal = {Annals of Medicine & Surgery}, volume = {87}, issue = {8}, pages = {4718-4720}, abstract = {Abstract unavailable}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Iqubal_2025, title = {Study of clinical presentation, diagnosis and various treatment modalities of liver abscess}, author = {Mohammed Asif Muzaffer Iqubal and Syed Sultan Mohiuddin Quadri and S. M. Saifuddin Quadri}, url = {https://www.academicmed.org/Uploads/Volume7Issue3/114.%205319.%20JAMP_Dr%20Makandar%20U.K_595-598.pdf}, doi = {10.47009/jamp.2025.7.3.114}, issn = {2687-5365}, year = {2025}, date = {2025-06-26}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {7}, issue = {3}, pages = {595-598}, abstract = {Background: Liver abscesses are mainly caused by parasitic or bacterial infection and are an important cause of hospitalization. The pathophysiology of abscess is different depending on the etiology and requires different strategies for diagnosis and management. Materials and Methods: Out of 150, 96 (64%) had amoebic liver abscesses and 54 (36%) had pyogenic liver abscesses. Blood examinations were CBP, LFT, X-ray of the abdomen (CT/MRI if required), and USG to study the extent of spread of the abscess. Initially treated with suitable antibiotics, needle aspiration + antibiotic therapy, surgical approach + antibiotics laparoscopic drainage + antibiotics. Result: Clinical manifestations of pyogenic or amoebic had more or less the same manifestations. The USG study had 39 pyogenic infections in the right lobe and 78 amoebic abscesses in the right lobe. In left 6 pyogenic and 6 amoebic abscesses. Both lobes had 9 amoebic and 9 pyogenic abscesses, pleural effusions 36 in pyogenic and 66 in amoebic, and Ascites 9 in pyogenic and 30 in amoebic. The majority of both abscesses were treated with antibiotics. Conclusion: Liver abscesses are more common in males with alcohol consumption. Successful management of liver abscess aspiration, catheter drainage can prevent the mortality of liver abscess patients.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025g, title = {Hot water epilepsy: a case report with EEG findings and clinical insights}, author = {Sandhya Manorenj and Eluka Mounika Reddy}, url = {https://sciencevolks.com/neurology/pdf/SVOA-NE-06-017.pdf}, doi = {10.58624/SVOANE.2025.06.017}, issn = {2753-9180}, year = {2025}, date = {2025-06-25}, urldate = {2025-06-25}, journal = {SVOA Neurology}, volume = {6}, issue = {3}, pages = {86-90}, abstract = {Hot water epilepsy (HWE) is a rare form of reflex epilepsy triggered by exposure to hot water, typically during baths, and can be difficult to diagnose due to normal electroencephalogram (EEG) results. This case outlines a 30-year-old woman who experienced recurrent seizures over five years while bathing in hot water. Despite her history of generalized epilepsy, her initial EEG and MRI results were unremarkable. A subsequent sleep-deprived video EEG detected ictal discharges originating from the frontal lobes, confirming epilepsy. The patient was advised to continue her anti-seizure medication and to avoid hot baths. The discussion emphasizes the challenges in identifying the anatomical substrate of HWE, as most cases typically involve the temporal or parietal regions. This case contributes to a deeper understanding of HWE by identifying frontal lobe discharges as a potential correlate and highlights the vital role of EEG in guiding treatment adjustments.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2025, title = {An overview of quorum sensing in Mycobacterium tuberculosis, tuberculosis and diabetes mellitus}, author = {Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/revmedmicrobiol/abstract/9900/an_overview_of_quorum_sensing_in_mycobacterium.126.aspx}, doi = {10.1097/mrm.0000000000000441}, issn = {2770-3169}, year = {2025}, date = {2025-06-23}, urldate = {2025-06-01}, journal = {Reviews and Research in Medical Microbiology}, volume = {XX}, issue = {XX}, pages = {XX-XX}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, abstract = {Every 15 s, a person worldwide dies due to tuberculosis (TB), a disease brought on by Mycobacterium tuberculosis (M. tb). One of the basic mechanisms by which bacteria impose collective behaviors is cell-to-cell communication called Quorum sensing mechanism (QSM). Patients with cystic fibrosis have frequently had sputum samples containing a wide genetic variety of mycobacteria. Due to minute modifications in their morphology, distributive conjugal transfer (DCT), and gene expression level, heterogenic mycobacterial populations are seen to arise. India became a focal point of the global tuberculosis (TB) crisis. The nation, which in 2020 reported the greatest number of projected incident cases of tuberculosis (1.5 million among a total predicted 5.8 million worldwide cases), has set an aggressive goal to eradicate tuberculosis by 2025, as opposed to the traditional deadline of 2030. According to estimates, India will have the second-highest number of diabetes cases worldwide in 2021 (74 million out of an anticipated 537 million cases). It has been highlighted that diabetes treatment, a significant comorbidity among TB patients, should be handled in tandem with TB treatment since early detection is likely to save patient expenditures. In the present review article, authors have given an overview on Quorum sensing in M. tb, Quorum sensing mechanism in M. tb and correlation between TB and diabetes mellitus (DM).}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Pitliya_2025, title = {Effects of blood pressure variability and its association with dementia and cognitive impairment: a systematic review}, author = {Aakanksha Pitliya and Aniket Jaimalani and Mizba Basheer Patel and Aditi Parulkar and Mahendra Kumar and Vanshika Batra and Sahaj Modi and Srivasta Surya Vasudevan and Anmol Pitliya}, url = {https://ijms.info/IJMS/article/view/2482/3034}, doi = {10.5195/ijms.2025.2482}, issn = {2076-6327}, year = {2025}, date = {2025-06-23}, urldate = {2025-06-23}, journal = {International Journal of Medical Students}, volume = {13}, issue = {2}, pages = {192-203}, abstract = {Background: This systematic review aimed to assess the relationship between blood pressure, cognitive function, and the potential for dementia in individuals with hypertension or at risk of developing hypertension. Methods: The review adhered strictly to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A comprehensive search was conducted in databases, including PubMed, Research Gate, Google Scholar, and Science Direct. The inclusion criteria required studies that examined the association between blood pressure variability and the occurrence or progression of dementia and cognitive impairment. Two independent reviewers evaluated each study's quality and potential bias using study-specific tools before inclusion. Results: There were 17 studies, including four systematic reviews and meta-analyses, four randomized controlled trials, and nine observational studies, with 16,985,492 participants. The findings indicated that late-life blood pressure had a stronger association with cognitive function than midlife blood pressure. Hypertension was linked to an increased risk of all-cause dementia, Alzheimer's disease, and vascular dementia. Anti-hypertensive medications could reduce the risk of dementia or cognitive impairment, although the specific type of medication did not significantly affect overall cognitive performance. A significant limitation of this review was the heterogeneity in diagnostic criteria, cognitive assessment tools, and imaging techniques used among the studies, which limited direct comparisons and conclusive findings. Conclusion: Blood pressure variability emerged as a potential predictor for cognitive impairment. Implementing strategies to reduce blood pressure variability may help mitigate the risk of dementia and improve cognitive outcomes in vulnerable populations.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Siddiqi_2025, title = {Impact of intermittent fasting on glycemic control in type 2 diabetes: an original research}, author = {Maarya Mohammed Siddiqi and Muneza Mariam Farhan and Mohammed Abdus Sami Amaan and Amaarah Ayesha Farhan and Afeefa Sufian}, url = {https://journals.lww.com/jpbs/fulltext/2025/09003/impact_of_intermittent_fasting_on_glycemic_control.114.aspx}, doi = {10.4103/jpbs.jpbs_1582_24}, issn = {0975-7406}, year = {2025}, date = {2025-06-20}, urldate = {2025-06-20}, journal = {Journal of Pharmacy and Bioallied Sciences}, volume = {17(Suppl 3)}, pages = {S2410-S2412}, abstract = {Background: “Type 2 diabetes (T2D)” requires effective glycemic control to prevent complications. “Intermittent fasting (IF)” is a potential lifestyle intervention that may improve glycemic outcomes, though evidence is still evolving. Objective: This study evaluated the impact of IF on glycemic control and metabolic health in T2D. Methods: One hundred adults with T2D were randomly assigned to an IF group (50 following an 8-h eating window) or a control group, non-dietary advice. The primary outcomes were glycated Hemoglobin A1c (HbA1C), and fasting glucose; secondary outcomes included “body mass index (BMI)” or waist circumference, a surrogate marker of central obesity, and insulin resistance by homeostasis model assessment-insulin resistance test (HOMA-IR). We performed hypothesis tests to test for changes within and between groups. Results: The IF group showed a significant drop in HbA1c (8.2 to 7.4%, P < 0.001), fasting glucose, BMI, waist circumference, and insulin resistance index by HOMA-IR (3.8 to 3; P < 0.01). Conclusion: IF significantly improved glycemic control, body composition, and insulin sensitivity in T2D patients, indicating its potential as a non-pharmacological management strategy. Further research is recommended to explore long-term effects and IF regimen variations.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Kumar_2025b, title = {A case of bilateral spiller syndrome}, author = {S. Sravan Kumar and Sandhya Manorenj and Chillapuram Shashanka}, url = {https://journals.lww.com/neur/fulltext/9900/a_case_of_bilateral_spiller_syndrome.108.aspx}, doi = {10.4103/neurol-india.Neurol-India-D-24-00780}, issn = {0028-3886}, year = {2025}, date = {2025-06-18}, urldate = {2025-06-18}, journal = {Neurology India}, abstract = {No abstract available}, note = {Online ahead of print}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Zoheb_2025, title = {Dynamin-related protein 1 expression as a non-invasive biomarker for mitochondrial dysfunction in Parkinson’s disease}, author = {Mohammed Zoheb and Tahmeen Jameel and Shaik Iqbal Ahmed and Safia Begum and Bushra and Aleem Ahmed Khan}, url = {https://rjn.com.ro/articles/2025.2/RJN_2025_2_Art-14.pdf}, doi = {10.37897/RJN.2025.2.14}, issn = {1843-8148}, year = {2025}, date = {2025-06-16}, urldate = {2025-06-16}, journal = {Romanian Journal of Neurology}, volume = {24}, issue = {2}, pages = {134-143}, abstract = {Background. Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss. Mitochondria-mediated mechanisms – including excessive fission, impaired fusion, defective mitophagy, and oxidative stress – contribute to its pathogenesis. However, the relationship between mitochondrial dynamics and PD progression remains poorly defined. Dynamin-related protein 1 (Drp1), a master regulator of mitochondrial fission, is implicated in neurodegeneration. This study assessed whether peripheral blood Drp1 gene expression reflects mitochondrial dysfunction in PD and may serve as a non-invasive biomarker. Materials and methods. Drp1 gene expression was analyzed by RT-qPCR in peripheral blood samples from 25 PD patients and 25 age- and sex-matched healthy controls. Results. Drp1 expression was significantly upregulated in PD patients, suggesting heightened mitochondrial fission. ROC curve analysis revealed an area under the curve (AUC) of 0.94, indicating strong diagnostic potential. Stratified analysis showed that patients aged ≥60 years had significantly higher Drp1 levels than younger patients, with a stratified AUC of 0.89. No significant sex-based differences were observed. Conclusion. These findings support the role of altered mitochondrial dynamics in PD and suggest that peripheral Drp1 expression may offer diagnostic value, particularly when stratified by age. Targeting mitochondrial dynamics may enable precision therapies to mitigate neurodegeneration. By identifying a potential non-invasive biomarker, this study contributes to understanding the molecular mechanisms of PD and informs future therapeutic development.}, keywords = {Biochemistry, Central Research Laboratory, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Qureshi_2025b, title = {Role of forehead flap in covering mid-face defects: a clinical observational study}, author = {Mohd. Rehan Qureshi}, url = {https://healthcare-bulletin.co.uk/article/role-of-forehead-flap-in-covering-mid-face-defects-a-clinical-observational-study-3589/}, doi = {10.5083/ejcm/25-06-45}, issn = {2042-4884}, year = {2025}, date = {2025-06-15}, urldate = {2025-06-15}, journal = {European Journal of Cardiovascular Medicine}, volume = {15}, issue = {6}, pages = {235-242}, abstract = {Introduction: Mid-face defects resulting from trauma, tumor excision, or infection pose a significant reconstructive challenge due to the complex anatomical and aesthetic considerations involved. The forehead flap remains a cornerstone in facial reconstruction due to its robust vascularity and tissue characteristics. Objectives: To evaluate the effectiveness and outcomes of the forehead flap technique in reconstructing mid-face defects. Methods: A prospective observational study was conducted on 25 patients with mid-face defects treated using forehead flap reconstruction at Deccan College of Medical Sciences, Princess Esra Hospital, between May 2022 and May 2025. Clinical evaluation, aesthetic outcomes, patient satisfaction, and complication rates were assessed. Results: Infection (8%), trauma (24%), and oncologic resections (68%), accounted for the majority of errors. Eighty percent of patients had excellent cosmetic results, with just two cases of flap congestion and one case of wound dehiscence. There was no flap loss noted. Eighty-eight percent of patients were satisfied. Conclusion: The forehead flap is a reliable and aesthetically favorable option for reconstructing mid-face defects, with a high rate of patient satisfaction and low complication rates.}, keywords = {Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kumar_2025, title = {A deadly duo: viper bite-induced coagulation disorder and multiple territory ischemic stroke}, author = {S. Sravan Kumar and Sandhya Manorenj}, url = {https://journals.lww.com/annalsofian/citation/9900/a_deadly_duo__viper_bite_induced_coagulation.436.aspx}, doi = {10.4103/aian.aian_1015_24}, issn = {0972-2327}, year = {2025}, date = {2025-06-11}, urldate = {2025-06-11}, journal = {Annals of Indian Academy of Neurology}, abstract = {No abstract available}, note = {Online ahead of print}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025f, title = {Isolated starfield pattern and the type 1 cerebral fat microembolism: a radiological perspective}, author = {Sandhya Manorenj and S. Sravan Kumar and Sravan Kumar Marupaka and Farah Naaz}, url = {https://journals.lww.com/annalsofian/fulltext/2025/05000/isolated_starfield_pattern_and_the_type_1_cerebral.19.aspx}, doi = {10.4103/aian.aian_1042_24}, issn = {0972-2327}, year = {2025}, date = {2025-06-09}, urldate = {2025-06-09}, journal = {Annals of Indian Academy of Neurology}, volume = {28}, number = {40485206}, issue = {3}, pages = {435-436}, abstract = {No abstract available}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Maryam_2025, title = {Emerging role of weight-loss medications in the management of heart failure: Current evidence and future perspectives}, author = {Maryam and Treesa P. Varghese and Bachi Tazneem and Gurrala Rajshekhar Reddy}, url = {https://link.springer.com/article/10.1007/s40256-025-00735-y}, doi = {10.1007/s40256-025-00735-y}, issn = {1179-187X}, year = {2025}, date = {2025-05-28}, urldate = {2025-05-01}, journal = {American Journal of Cardiovascular Drugs}, volume = {XX}, issue = {XX}, pages = {XX-XX}, publisher = {Springer Science and Business Media LLC}, abstract = {Heart failure is a major global health concern as it contributes to high rates of mortality and morbidity, with high rates of hospitalizations. The most prevalent risk factor or comorbidity of heart failure is obesity, which not only worsens and exacerbates disease progression and the course of illness, it also reduces its prognosis. Weight management is still not well addressed, even with major advancements in heart failure pharmacotherapies. Recent advances in weight-loss medications such as glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and other novel anti-obesity drugs have sparked interest in their potential to improve clinical outcomes for patients with heart failure, especially those who also have obesity-related cardiac dysfunction. Weight-loss medications benefit heart failure by reducing adiposity-related inflammation, myocardial stress, and remodeling. These effects are auspicious in heart failure with preserved ejection fraction, where obesity-driven mechanisms play a critical role. These medications have been demonstrated to help with weight reduction, improve heart failure symptoms, and reduce hospitalization rates. However, questions about their long-term safety, particularly in patients with severe heart failure, are still being researched. The purpose of this review is to summarize the current evidence on the safety and effectiveness of weight-loss medications in the treatment of heart failure, describe their mechanisms of action, and highlight knowledge gaps that require further research.}, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @article{Hassan_2025b, title = {An atypical case of Sjögren's syndrome: a surprise diagnosis}, author = {Syed Hassan and Sara Samreen and Faiz Fathima Shaik and Syeda Maariyah Hashmi and Abdul Shafi}, url = {https://assets.cureus.com/uploads/case_report/pdf/288512/20250625-390560-cu7i0k.pdf}, doi = {10.7759/cureus.84807}, issn = {2168-8184}, year = {2025}, date = {2025-05-25}, urldate = {2025-05-25}, journal = {Cureus}, volume = {17}, issue = {5}, pages = {e84807}, abstract = {Distal renal tubular acidosis (RTA) presenting as hypokalemia, metabolic acidosis, and hypokalemic periodic paralysis is a common manifestation of tubulointerstitial nephritis (TIN) in Sjögren’s syndrome. Sjögren’s syndrome is a chronic, progressive, systemic autoimmune inflammatory disease characterized by lymphocytic infiltration of exocrine glands, which results in sicca syndrome, i.e., xerostomia and keratoconjunctivitis sicca. Some patients can express sicca symptoms with other autoimmune diseases. It is mostly seen in females, and middle-aged women are more likely to be affected. Some patients can present with extra-glandular (systemic) manifestations, of which renal involvement is the most common. Renal involvement in the form of TIN is more common compared to glomerular involvement. We report a case of a 37-year-old female presenting with hypokalemic periodic paralysis, later diagnosed as distal RTA secondary to Sjögren’s syndrome, which requires high clinical suspicion based on hypokalemia refractory to treatment. Further evaluation is necessary to confirm the diagnosis.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025e, title = {Teaching video neuroImage: palmo-facial reflex a variant of the palmomental reflex}, author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka and Eluka Mounika Reddy}, url = {https://www.neurology.org/doi/full/10.1212/WNL.0000000000213731}, doi = {10.1212/WNL.0000000000213731}, issn = {0028-3878}, year = {2025}, date = {2025-05-22}, urldate = {2025-05-22}, journal = {Neurology}, volume = {104}, issue = {12}, pages = {e213731}, abstract = {No abstract available}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Durdana_2025, title = {Diffuse panbronchiolitis with secondary amyloidosis in a young Indian woman: a rare case report}, author = {Asfa Durdana and Ashfaq Hasan and Fahad Abdullah Bin Breik and Syed Mahmood Ahmed and M. Aleemuddin Naveed and Mohammed Raheem Hussain and Mohammed Abdul Basith and Thamee Shahid and Moid Mir Siddiq Ali }, url = {https://www.atsjournals.org/doi/epdf/10.1164/ajrccm.2025.211.Abstracts.A6070?role=tab}, doi = {10.1164/ajrccm.2025.211.Abstracts.A6070}, isbn = {1073-449X}, year = {2025}, date = {2025-05-20}, urldate = {2025-05-20}, journal = {American Journal of Respiratory and Critical Care Medicine}, volume = {211}, pages = {A6070}, publisher = {American Thoracic Society}, abstract = {Introduction: Diffuse panbronchiolitis (DPB) is a rare, progressive inflammatory disease primarily affecting the respiratory bronchioles and is most common in East Asian populations. Clinical diagnosis of DPB requires a high index of suspicion, supported by imaging and histology. We present a rare case of DPB with secondary amyloidosis in a young Indian female patient. Case Presentation: A 25-year-old woman with a history of asthma, chronic sinusitis, and prior pulmonary tuberculosis presented with worsening dyspnea and cough over four weeks. Despite aggressive therapy, her condition deteriorated, and bronchoscopy cultures revealed non-tuberculous mycobacteria (NTM). Chest CT showed cystic bronchiectasis and thickened bronchial walls. Due to her persistent symptoms, video-assisted thoracoscopic surgery (VATS) was performed, revealing hallmark DPB findings, including bronchiectasis with dense peribronchiolar inflammation, interstitial infiltration, and fibrosis. Secondary amyloidosis was confirmed on renal biopsy. Her condition progressively worsened over a decade, requiring oxygen support as she developed respiratory failure. Lung transplantation was offered but declined, and she was managed with conservative care. Discussion: The etiology of DPB remains uncertain, though genetic factors, infections, and environmental influences are believed to play a role. It is characterized by persistent cough, sputum production, and dyspnea, with potential for progression to bronchiectasis, respiratory failure, and death if untreated Hallmark features include characteristic imaging and histological findings, coexisting sinusitis, and recurrent respiratory infections, often due to Haemophilus influenzae and Pseudomonas aeruginosa. Without timely intervention, DPB can lead to bronchiectasis, respiratory failure, and ultimately, death. Distinctive histological features on biopsy, such as peribronchiolar inflammation with foamy macrophages and interstitial fibrosis, were key diagnostic criteria that supported the diagnosis of DPB in this patient. Co-infection with non-tuberculous mycobacteria also underscores the role of recurrent infections in exacerbating lung damage in DPB. The development of secondary amyloidosis reflects the chronic inflammatory nature of DPB and its systemic impacts on other organs. The patient's progressive decline, despite optimal medical management, underscores the limitations of current therapies in halting disease progression, highlighting lung transplantation as a potential, albeit challenging, option for end-stage cases. Comprehensive care for DPB necessitates a multidisciplinary approach to manage complications and improve quality of life in affected individuals. Conclusion: Our case highlights the diagnostic and therapeutic challenges in managing DPB, especially outside East Asia. The patient's progressive decline underscores the need for early consideration of lung transplantation in cases unresponsive to conventional treatment}, note = {This abstract was presented at American Thoracic Society Conference 2025 }, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Rahman_2025, title = {Assessing occupational health hazards among solid waste workers in a developing country: a cross-sectional mixed-methods study from a metropolitan city in India}, author = {Mohammed Zia ur Rahman and Tabassum Warda and Mohammed Sarosh Ahmed and Asrar ul Haq and Zubia Naaz and Zayeem Ahmed and Juveria Fatima and Fariha Inamdar and Ifrah Makeen and Khan Umair Pathanissa and Sidra Rasheed and Zeba Tabassum and Yaserah Fatima}, url = {https://www.atsjournals.org/doi/epdf/10.1164/ajrccm.2025.211.Abstracts.A4211?role=tab}, doi = {10.1164/ajrccm.2025.211.Abstracts.A4211}, issn = {1073-449X}, year = {2025}, date = {2025-05-20}, urldate = {2025-05-20}, journal = {American Journal of Respiratory and Critical Care Medicine}, volume = {211}, issue = {Abstracts}, pages = {A4211}, abstract = {Rationale: The world generates approximately 2.01 billion tonnes of solid waste annually, projected to rise to 3.40 billion tonnes by 2050. This growth significantly strains waste management systems, particularly in developing countries like India. In Hyderabad, Telangana, municipal solid waste (MSW) workers play a vital role in waste collection, sorting, and disposal but face severe occupational health risks. This study aims to investigate the health hazards and safety compliance issues among MSW workers, providing insights to enhance health and safety measures in the sector. Methods: This observational, cross-sectional study employed a mixed-methods approach involving 150 MSW workers from various roles, including waste collection, sorting, and transportation. Workers were selected through convenience sampling, focusing on those with at least six months of experience. Data collection utilized a pre-designed, pre-tested questionnaire covering demographics, work environment, safety practices, and health systems. Direct interviews were conducted in participants' local language, and observational assessments of work conditions and PPE compliance were performed. Ethical approval was granted by the Institutional Review Board (IRB), with informed consent obtained from all participants to ensure confidentiality and the right to withdraw at any time. Data analyzed using SPSS and chi-square tests to explore correlations between job roles and health risks. Results: The findings revealed diverse age and gender distributions, body mass indices (BMI), work types, and years of experience. Among the workers surveyed, 66% reported physical injuries during waste handling, but only 29% reported these injuries to supervisors, mainly due to a lack of awareness and the perception that injuries were not serious. Health assessments indicated a high prevalence of health hazards: 90% experienced musculoskeletal symptoms, 67% had dermatological issues, 66% reported respiratory symptoms, and 56% faced gastrointestinal symptoms. A chi-square analysis showed a significant relationship between injury frequency and PPE usage (chi-square value = 13.21, p = 0.03), highlighting that inconsistent PPE use contributes to higher injury rates. Health risks varied significantly by job role, with garbage collectors and street sweepers facing more severe symptoms than waste transporters and recycling sorters. While 66% of workers reported receiving vaccinations, many perceived inadequate access to vaccination programs. Conclusion: These findings underscore serious health risks among MSW workers in a developing country, driven by inconsistent PPE use, insufficient training, and limited healthcare access. Implementing enhanced health and safety protocols, improving access to PPE, and establishing targeted health programs are essential to safeguard this workforce in the face of growing urban challenges.}, note = {This abstract was presented at American Thoracic Society Conference 2025 }, keywords = {Community Medicine, No Department}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2025, title = {Comparitive study of injection carbetocin and injection oxytocin in prevention of postpartum hemorrhage}, author = {Surayya Tahseen and Zareena Sultana and Urusa and Summaiyah Yousuf}, url = {https://www.ijmedph.org/Uploads/Volume15Issue3/34.%202295._IJMEDPH_Jafar_187-191.pdf}, doi = {10.70034/ijmedph.2025.3.34}, issn = {2230–8598}, year = {2025}, date = {2025-05-19}, urldate = {2025-05-19}, journal = {International Journal of Medicine and Public Health}, volume = {15}, issue = {3}, pages = {187-191}, abstract = {Background: The aim is to study efficacy of heat stable oxytocin analogue injection carbetocin in prevention of PPH in comparision to injection oxytocin by an observational study in 300 patients delivering both vaginally and by caesarean section. Materials and Methods: The study was conducted at Deccan College of Medical Sciences (Owaisi Hospital and Research Centre and Princess Esra Hospital). The study was conducted from JULY 2023- DEC 2024(18 MONTHS). It is a prospective study comparing injcarbetocin and inj oxytocin in prevention of PPH.300 woman delivering vaginally and by caesarean section were given injcarbetocin and inj oxytocin alternately after delivery of the baby. PPH is preventable and important cause for maternal morbidity and mortality. Patients were divided into two groups 150 each. Group A received injcarbetocin and group B received inj oxytocin after the delivery of the baby. Results: The dose of injcarbetocin was 1 ml containing 100 microgram carbetocin which was administered by I.M route after the delivery of the baby in vaginal and caesarean deliveries. The dose of inj oxytocin was 10 IU by I.M administration after the delivery of the baby in vaginal and caesarean deliveries. In both the groups the blood loss intrapartum and postpartum was not of much difference. The heat stable carbetocin does not require cold chain for maintenance in contrast to oxytocin which needs cold chain maintainance. Hence its use can be encouraged in developing countries where maintaining cold chain can be challenging. Conclusion: From this study we come to a conclusion that both injcarbetocin and inj oxytocin are equally efficacious in preventing PPH with equal amount of blood loss intra partum and postpartum. }, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Sakarwala_2025, title = {Bridging ethics, religion, and policy: transforming organ donation in South Asia}, author = {Aasiya Shahbaz Sakarwala and Aniqa Dejwani and Mohammed Faris Razi Moinuddin and Waleed Ahmad and Humam Furqan}, url = {https://innovapath.us/index.php/IN/article/view/27/25}, doi = {10.63501/aczjpq11}, issn = {3067-8102}, year = {2025}, date = {2025-05-18}, urldate = {2025-05-18}, journal = {INNOVAPATH:Journal of Translational Medicine & Biotechnology}, volume = {1}, issue = {3}, pages = {1-6}, abstract = {Background:Organ transplantation provides a vital solution for patients with end-stage organ failure; however, deceased organ donation rates in South Asia remain critically low. Cultural taboos, religious misconceptions, ethical concerns about brain death, and systemic socioeconomic inequities hinder donation efforts. Public mistrust and policy inconsistencies further exacerbate the shortage of available organs. Objective:This research explores how ethics, religion, and policy intersect to influence organ donation practices in South Asia. It identifies key barriers and proposes culturally appropriate strategies to increase deceased donation rates while ensuring equitable, ethical, and sustainable transplantation systems. Methods:A qualitative study was conducted using semi-structured interviews, questionnaires, and document analysis involving transplant surgeons, medical students, NGOs, and transplant candidates. A thematic analysis identified recurrent ethical, religious, and policy-related challenges. Literature review, expert consultations, and examination of religious texts and regional policies informed the findings. Key findings:Organ donation in South Asia faces multifactorial barriers. Public misconceptions about brain death are widespread, often conflated with coma or vegetative states. Religious hesitancy persists despite theological endorsements for donation in Islam, Hinduism, and Jainism. Rural populations and low-income groups experience greater reluctance due to cultural beliefs about bodily integrity and systemic inequities in healthcare access. Policy gaps, inconsistent brain death criteria, and inadequate infrastructure hinder donor recruitment and transplantation logistics. Community distrust toward healthcare institutions impedes acceptance of deceased donation. Collaborative efforts between healthcare professionals and religious leaders, combined with public education and policy reforms, emerged as critical pathways for improvement. Conclusion & Recommendations:Transforming organ donation in South Asia requires a multifaceted approach integrating ethical governance, religious support, and technological innovation. Key recommendations include establishing standardized brain death criteria, implementing opt-out consent trials with religious leader support, appointing transplant coordinators, and creating AI-based organ matching systems. Development of regional organ-sharing networks, drone transport, blockchain donor registries, and green corridors can improve efficiency and transparency. Religious endorsement libraries, hospital chaplaincies, and culturally tailored education campaigns can foster trust and awareness. Equitable financial protections, anti-trafficking enforcement, and oversight of emerging transplantation technologies are essential to build sustainable, ethical organ donation systems across South Asia.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hassan_2025, title = {A clinical study on post-operative pain management}, author = {Khaja Ali Hassan and Syed Asrar Hussain and Mohammed Ahsan Ullah Siddiqui }, url = {https://jccpractice.com/article/a-clinical-study-on-post-operative-pain-management-663/}, doi = {10.61336/jccp/25-05-24}, issn = {2457-7200}, year = {2025}, date = {2025-05-12}, urldate = {2025-05-12}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {5}, pages = {170-176}, abstract = {Background: Effective postoperative pain management is essential for patient recovery and quality of care. Analgesics, especially opioids and non-opioids, are commonly used in clinical practice, yet their efficacy and patterns of use require continual assessment. Objective: This study aimed to evaluate the analgesic regimens employed and their effectiveness in pain control among 100 postoperative patients, analyzing Numeric Rating Scale (NRS) scores over 48 hours. Methods: A prospective observational study was conducted involving 100 patients undergoing elective and emergency surgeries. Data on demographics, type of surgery, analgesics administered, and NRS scores at 6, 12, 24, and 48 hours postoperatively were collected and analyzed. Results: Tramadol and paracetamol were universally used, with 90% of patients receiving additional non-opioids. Mean NRS scores showed a significant decline from 7.91 at 6 hours to 5.08 at 48 hours, indicating effective pain management over time. Conclusion: Opioid and non-opioid analgesic combinations were effective in reducing postoperative pain. Further studies are recommended to explore multimodal pain management strategies tailored to surgical types and patient profiles.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Shahid_2025, title = {Prognostic value of high-sensitivity troponin in predicting long-term cardiovascular outcomes in patients with type 2 diabetes: a systematic review}, author = {Muhammad Hamza Shahid and Nisha Ali and Mounica Ratnala and Rehan Ishaque and Hamesh Gundala Raja and Roohollah Rahbani and Mir Ashar Ali and Mohammed Sadat Mohiuddin and Haroon Bin Idrees and Nishat Jahan Chowdhury and Amir Ali}, url = {https://assets.cureus.com/uploads/review_article/pdf/359363/20250611-245978-5adxrn.pdf}, doi = {10.7759/cureus.83925}, issn = {2168-8184}, year = {2025}, date = {2025-05-11}, urldate = {2025-05-11}, journal = {Cureus}, volume = {17}, issue = {5}, pages = {e83925}, abstract = {Cardiovascular disease remains the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). While conventional risk assessment tools often lack precision in diabetic populations, high-sensitivity cardiac troponins (hs-cTn), particularly high-sensitivity troponin T (hs-TnT) and high-sensitivity troponin T I (hs-TnI), have emerged as promising biomarkers capable of detecting subclinical myocardial injury and predicting adverse cardiovascular outcomes. This systematic review aimed to evaluate the prognostic effectiveness of hs-cTn in predicting long-term cardiovascular events in individuals with T2DM. A comprehensive search of PubMed, Scopus, and Web of Science was conducted for studies published up to March 2025, limited to English-language human studies. Only four studies met the inclusion criteria, reflecting the limited but focused evidence base. These studies varied in population characteristics, ranging from stable outpatients to patients with diabetic nephropathy and post-acute coronary syndrome, and in the outcomes assessed, including cardiovascular and all-cause mortality, heart failure, and renal events. Given this heterogeneity in both populations and endpoints, a narrative synthesis approach was adopted. Despite differences, elevated hs-cTn levels were consistently associated with worse long-term outcomes, although the strength of associations varied, with more consistent predictive value observed for cardiovascular and all-cause mortality compared to renal events. While findings support the potential of hs-cTn as a risk stratification tool in T2DM, the small number of eligible studies and variability in study designs limit generalizability and highlight the need for further research.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Qureshi_2025, title = {Role of locoregional flap in fingertip injury}, author = {Mohd. Rehan Qureshi}, url = {https://healthcare-bulletin.co.uk/article/role-of-locoregional-flap-in-fingertip-injury-3590/}, doi = {10.5083/ejcm/25-05-169}, issn = {2042-4884}, year = {2025}, date = {2025-05-10}, urldate = {2025-05-10}, journal = {European Journal of Cardiovascular Medicine}, volume = {15}, issue = {5}, pages = {881-889}, abstract = {Introduction: Fingertip injuries are among the most common hand traumas and can significantly impact hand function and quality of life. Proper reconstruction is essential for preserving tactile sensation and aesthetics. Locoregional flaps are frequently employed in fingertip reconstruction due to their simplicity and effectiveness. Objective: To evaluate the functional and aesthetic outcomes of locoregional flaps in the management of fingertip injuries. Methods: This prospective observational study was conducted over a period of three years, from May 2022 to May 2025, at the Department of Plastic Surgery, Deccan College of Medical Sciences, Princess Esra Hospital. A total of 40 patients with fingertip injuries requiring flap coverage were included. Depending on the type and location of the injury, several locoregional flaps were utilised, including V-Y advancement flaps, thenar flaps, and cross-finger flaps. In order to evaluate flap viability, wound healing, function recovery, and cosmetic results, patients were monitored. Results: Most patients demonstrated good functional recovery with minimal complications. Flap survival rate was high, and the majority of patients reported satisfactory aesthetic results. Early intervention and appropriate flap selection were key factors contributing to successful outcomes. Conclusion: In order to effectively treat injuries to the fingertip, locoregional flaps are essential because they provide dependable covering with positive functional and aesthetic outcomes. In reconstructive hand surgery, this method is still useful and practical.}, keywords = {Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Goud_2025, title = {Single-staged repair for penoscrotal hypospadias with tunica vaginalis flap}, author = {P. Umesh Chandran Goud and Loya Bharadwaj and Shireen Adeeb Mujtaba Ali and Mohammad Ikramuddin and Mohammed Khaja Arifuddin}, url = {https://journals.lww.com/sbvj/fulltext/2025/04000/single_staged_repair_for_penoscrotal_hypospadias.9.aspx}, doi = {10.4103/sbvj.sbvj_15_25}, issn = {2581-6039}, year = {2025}, date = {2025-04-30}, urldate = {2025-04-01}, journal = {SBV Journal of Basic, Clinical and Applied Health Science}, volume = {8}, issue = {2}, pages = {75–77}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, abstract = {Surgery at an early age is recommended for one of the most prevalent congenital genital defects, hypospadias. It is gradually evolving, frequently by repurposing decades-old therapeutic approaches. Preputial onlay flaps were most frequently utilized in the 1980s, although there is currently a resurgence of interest in the tunica vaginalis flap. In a selected number of patients with severe anomalies, hypospadias is surgically repaired in one stage. The process includes creating a neourethra and correcting the curvature of the penile shaft. For optimal functional and cosmetic outcomes, this neourethra requires an intermediate layer to be covered. The tunica vaginalis flap is one of the better choices for usage as an intermediate layer among the several local flaps.}, keywords = {Central Research Laboratory, General Surgery, Urology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025b, title = {Airway management in a case of rhinophyma excision}, author = {Naseeba Fatima and Syed Atif Ullah Hussaini and Umesh Jayshree and Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/sbvj/fulltext/2025/04000/airway_management_in_a_case_of_rhinophyma_excision.11.aspx}, doi = {10.4103/sbvj.sbvj_14_25}, issn = {2581-6039}, year = {2025}, date = {2025-04-30}, urldate = {2025-04-01}, journal = {SBV Journal of Basic, Clinical and Applied Health Science}, volume = {8}, issue = {2}, pages = {81–83}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, abstract = {Rhinophyma is a progressive enlargement of the nose caused by sebaceous gland proliferation. In this case, the condition was neglected until it obstructed the patient’s vision, necessitating surgical excision with grafting. The extensive nasal enlargement posed significant challenges for airway management, particularly in bag-mask ventilation and tracheal intubation. Given the anticipated difficulty, awake tracheal intubation was planned using airway nerve blocks and topical anesthesia. The use of regional anesthesia techniques minimized the risk of hypoxia and ensured patient comfort during the procedure. This case highlights the importance of meticulous airway planning and the role of nerve blocks in managing difficult airways in patients with extensive rhinophyma. Our report emphasizes the efficacy and safety of regional airway anesthesia as a valuable approach in challenging intubation scenarios.}, keywords = {Anesthesiology, Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Akhtar_2025, title = {Vulvar leiomyoma: an unusual entity at a rare anatomical site}, author = {Mohtashim Idrees Akhtar and Naushaba Tazeen and Idrees Akhtar Afroze and Atiya Begum}, url = {https://ijnrd.org/papers/IJNRD2504372.pdf}, doi = {10.56975/ijnrd.v10i4.305369 }, issn = {2456-4184}, year = {2025}, date = {2025-04-30}, urldate = {2025-04-30}, journal = {International Journal of Novel Research and Development}, volume = {10}, issue = {4}, pages = {d432-d436}, abstract = {Vulvar leiomyoma is a rare soft tissue tumor, accounting for only 0.03% of all gynecological tumors, which often leads to misdiagnosis. Leiomyoma is a type of smooth muscle tumor that primarily occurs in the uterus and is commonly known as a fibroid. However, extrauterine fibroids are quite rare and can be found in various locations, including the vulva, vagina, ovaries, urinary bladder, urethra, round ligaments, uterosacral ligaments, inguinal canal, retroperitoneum, sinonasal cavities, and even the kidneys. Vulvar leiomyoma typically affects women of reproductive age and can mimic conditions such as Bartholin’s cyst or abscess. Histologically, vulvar leiomyomas generally exhibit spindle-shaped cells, though other variants, such as the epithelioid subtype, have also been reported. In this report, we present a case of vulvar leiomyoma that was misdiagnosed as a Bartholin’s cyst before surgery.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Kataria_2025, title = {Tuberculous chronic palmar bursitis and flexor tenosynovitis of the wrist: a case report}, author = {Shweta Kataria and Saurabh Gangwar and Sravan Kumar Marupaka and Abhijeet Ingle}, url = {https://assets.cureus.com/uploads/case_report/pdf/345457/20250521-175546-mcknjq.pdf}, doi = {10.7759/cureus.82652}, issn = {2168-8184}, year = {2025}, date = {2025-04-20}, urldate = {2025-04-20}, journal = {Cureus}, volume = {17}, issue = {4}, pages = {e82652}, abstract = {Palmar bursitis and tenosynovitis of the flexor tendon sheath around the wrist is a rare manifestation of musculoskeletal tuberculosis. It has an indolent course and diagnosis is often delayed especially when it is an isolated finding. Timely diagnosis can prevent complications like bony involvement, tendon rupture and neuropathy. Here, we report a case of a 42-year-old male patient who presented with gradually progressive painful swelling of the left palm, wrist and distal forearm. Ultrasound and MRI revealed synovial thickening and distension of the palmar bursae and flexor tendon sheath with fluid and rice bodies. Open excisional biopsy was done, and thickened synovium and rice bodies were removed. Histopathology showed epithelioid granulomas with Langhans type giant cells and caseation necrosis. Anti-tubercular therapy was administered, and on follow-up, there was no recurrence of symptoms.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Kadloor_2025, title = {Prevalence of hypertension and associated risk factors in urban and rural populations - A cross-sectional study}, author = {Parvaiz Kadloor and Siddhartha Rout and Sayed Mohammed Hussain Bangi}, url = {https://healthcare-bulletin.co.uk/article/prevalence-of-hypertension-and-associated-risk-factors-in-urban-and-rural-populations-a-cross-sectional-study-3191/}, issn = {2042-4884}, year = {2025}, date = {2025-04-19}, urldate = {2025-04-19}, journal = {European Journal of Cardiovascular Medicine}, volume = {15}, issue = {4}, pages = {649-653}, abstract = {Introduction: Hypertension is a major public health issue globally, with varying prevalence across different demographics and geographical locations. This study aims to assess the prevalence and associated risk factors for hypertension in urban and rural populations to identify targeted interventions. Methods: This cross-sectional study involved 500 participants, equally divided between urban and rural settings. Data were collected through health surveys and physical examinations, focusing on hypertension status, demographic variables, lifestyle factors, and access to healthcare services. Statistical analysis included chi-square tests, t-tests, and logistic regression. Results: The prevalence of hypertension was significantly higher in rural areas (40.8%) compared to urban areas (34.8%) (p=0.045). Rural participants were older and had higher mean body mass index. Factors such as smoking and family history of hypertension were more prevalent in rural populations. Urban residents reported better healthcare access and higher engagement in health awareness programs. Lifestyle factors such as dietary salt intake and physical activity also differed significantly between the two groups. Conclusion: Hypertension prevalence is significantly influenced by geographic location, with rural populations exhibiting higher rates and associated risk factors. Differences in lifestyle behaviors and healthcare accessibility suggest the need for region-specific health policies and programs to manage and prevent hypertension effectively.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Asimuddin_2025, title = {Assessment of quality of life and functional status of breast cancer survivors at a tertiary cancer centre}, author = {Mohd. Asimuddin and Sai Teja Adepu and Nagasai Divya Kari and M. Ramakrishna and Kanugula Sravanthi}, url = {https://jccpractice.com/article/assessment-of-quality-of-life-and-functional-status-of-breast-cancer-survivors-at-a-tertiary-cancer-centre-541/}, doi = {10.61336/jccp/25-042}, issn = {2457-7200}, year = {2025}, date = {2025-04-13}, urldate = {2025-04-13}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {4}, pages = {257-271}, abstract = {Background: With improved screening and treatment modalities, the survival rate of breast cancer patients has significantly increased. However, survivorship brings its own challenges, including physical, psychological, and social sequelae that affect the quality of life (QoL) and functional status of survivors. Aim: To assess the quality of life and functional status in breast cancer survivors. Methods: A cross-sectional study was conducted among breast cancer survivors attending the oncology outpatient department of a tertiary cancer care center. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and its breast cancer-specific module (QLQ-BR23) were administered to evaluate QoL and functional outcomes. Sociodemographic and clinical data were also collected. Descriptive statistics and inferential analyses (chi-square, t-test) were used to determine significant associations. Results: Among the survivors (N = XX), the mean global health status/QoL score was XX. Functional domains such as emotional and physical functioning were notably compromised. Symptoms such as fatigue, pain, and arm swelling were prevalent. Lower QoL scores were significantly associated with advanced stage at diagnosis, comorbidities, and recent completion of treatment (p < 0.05). Conclusion: Breast cancer survivors face ongoing challenges that impair their quality of life and functional capacity. Integration of routine QoL assessments into follow-up care and provision of psychosocial support services are essential for holistic survivorship care.}, keywords = {Radiation Oncology}, pubstate = {published}, tppubtype = {article} } @article{Aziz_2025b, title = {Are females more prone to thyroid dysfunctions in metabolic syndrome-a retrospective cohort study}, author = {Nusrat Aziz and Farah Bahmed and Shobha Mohammed and Mujahid Mohammed}, url = {https://journals.lww.com/jdrntruhs/fulltext/2025/04000/are_females_more_prone_to_thyroid_dysfunctions_in.10.aspx}, doi = {10.4103/jdrntruhs.jdrntruhs_94_23}, issn = {2950-5348}, year = {2025}, date = {2025-04-01}, urldate = {2025-04-01}, journal = {Journal of Dr. NTR University of Health Sciences}, volume = {14}, issue = {2}, pages = {187-190}, abstract = {Introduction: Metabolic syndrome or Insulin resistance syndrome is a multifactorial disorder associated with the development of cardiovascular, neurological, immunological, renal and endocrine disease. Metabolic syndrome (MetS) is a condition characterised by a group of metabolic abnormalities, with insulin resistance (IR) being a common cause. Our study aims to evaluate the need for thyroid dysfunction and the prevalence of MetS in males and females. Materials and Methods: A retrospective study with a total no of 100 enrolled patients of both genders who satisfied the inclusion criteria of the International Diabetes Federation of Metabolic Syndrome was randomly allocated to the study. The study was conducted between September 2019 and September 2022. The significance level was tested at p < 0.05 with a 95% confidence interval (CI) and 80% power of the study. Results: The study subjects were between 18 and 60 years old, with 35% males and 65% females. The mean age of patients with metabolic syndrome was 41.5 ± 18.5. A conclusion was drawn using the ANOVA Brown-Forsythe test, with an F value of 536.7 and a p-value of < 0.0001. Thyroid function test revealed that 48 patients were Euthyroid, 30 patients were Hypothyroid, 8 patients were Subclinical Hypothyroid, 7 patients were subclinical hyperthyroid, and none were Hyperthyroid. Thyroid dysfunction is 52% prevalent in Metabolic syndrome patients. Among Thyroid dysfunction, hypothyroidism is 30%, Subclinical Hypothyroidism is highly prevalent at 8%, and subclinical Hyperthyroidism is at 7%. There were no Hyperthyroid patients in the study. To prove the statistical significance, a chi-square test was used with 1 degree of freedom, p < 0.0079. Conclusion: The results suggested that patients with metabolic syndrome have a significantly increased chance of thyroid dysfunction, and the prevalence of thyroid dysfunction is higher in female patients compared to males. Females may be more prone to thyroid dysfunction in metabolic syndrome.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Ayesha_2025, title = {A case series on rhinoscelroma at tertiary care hospital at Hyderabad}, author = {Syeda Ayesha}, url = {https://www.ijmedph.org/Uploads/Volume15Issue1/154.%20[1589.%20IJMEDPH_Adnan]%20826-828.pdf}, doi = {10.70034/ijmedph.2025.1.154}, issn = {2230-8598}, year = {2025}, date = {2025-03-31}, urldate = {2025-03-31}, journal = {International Journal of Medicine and Public Health}, volume = {15}, issue = {1}, pages = {826-828}, abstract = {Rhinoscleroma is a long-lasting, progressive inflammatory disorder affecting the upper respiratory tract, linked to the Klebsiella rhinoscleromatis infection. This case series outlines the clinical and pathological characteristics seen in four patients diagnosed with rhinoscleroma at the Deccan College of Medical Sciences in Hyderabad from 2020 to 2024. Each patient exhibited cutaneous symptoms exclusively, and histological analysis confirmed the diagnosis. The patients were treated with a combination of antibiotics. Due to the rarity of rhinoscleroma in Hyderabad, diagnosing it can be quite challenging. This report aims to increase awareness about the disease to facilitate early diagnosis and treatment for those affected. Without proper intervention, rhinoscleroma can result in serious complications, such as involvement of the lower airways. Therefore, early detection and prompt treatment are crucial for reducing the morbidity associated with this condition.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Ayesha_2025b, title = {Fungal otitis externa as a cause of tympanic membrane perforation: a case series}, author = {Syeda Ayesha}, url = {https://www.ijmedph.org/Uploads/Volume15Issue1/175.%20[1546.%20IJMEDPH_Adnan]%20939-940.pdf}, doi = {10.70034/ijmedph.2025.1.175 }, issn = {2230–8598}, year = {2025}, date = {2025-03-31}, urldate = {2025-03-31}, journal = {International Journal of Medicine and Public Health}, volume = {15}, issue = {1}, pages = {939-940}, abstract = {This report talks about 13 patients who had a serious ear infection caused by fungus, which led to holes in their eardrums. The group included 10 men and 3 women, aged between 18 and 70 years, with an average age of 49. These patients had ongoing ear problems that did not get better with usual treatments. They experienced symptoms like ear discharge, ear pain, and itching. Out of the 13 patients, six had no previous ear issues. Four were sent to specialists by their family doctors, five came from ear doctors, and three came on their own. Treatment included careful cleaning of the ears and one of two types of antifungal medicine. After treatment, nine patients fully recovered, including healing their eardrum holes. However, three patients needed surgery to fix their eardrums. This study shows that fungal ear infections can be hard to diagnose, but with the right medical care, most eardrum holes caused by this infection can heal without needing surgery. }, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Raheem_2025, title = {COVID-19 vaccine hesitancy among medical and nonmedical undergraduate students: a cross-sectional study}, author = {Juwairiah Abdur Raheem and Saimah Naseer and Mohammed Imtiyazuddin and Mehnaaz Sameera Arifuddin}, url = {https://journals.lww.com/mjhs/fulltext/2025/07000/covid_19_vaccine_hesitancy_among_medical_and.14.aspx}, doi = {10.4103/mjhs.mjhs_60_24}, issn = {2321-7006}, year = {2025}, date = {2025-03-29}, urldate = {2025-03-29}, journal = {MRIMS Journal of Health Sciences}, volume = {13}, issue = {3}, pages = {162-165}, abstract = {Vaccine hesitancy poses a threat to not only one’s life but also others surrounding them. Vaccine hesitancy is indirectly related to vaccine coverage, and it is therefore important to reduce it by finding out its prevalence and root cause. The objective was to compare the burden and reasons for vaccine hesitancy among medical and nonmedical students. A cross-sectional study was conducted. Data were collected using Google Forms forwarded to medical and nonmedical students through various social media platforms over 3 months. COVID-19 vaccine hesitancy was 33.51% in medical students compared to 66.48% in nonmedical students. About 5.67% of medical and 18.64% of non-medical students who refused vaccine was due to their fears on the effectiveness of the vaccine. We conclude that nonmedical students exhibited greater vaccine hesitancy compared to medical students. A primary concern was about vaccine’s impact on genetics and doubts about its effectiveness, stemming from perceptions of rushed trials.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025, title = {Anaesthesia management of a primigravida with scoliosis posted for elective caesarean section}, author = {Naseeba Fatima and Shaikh Wasim Akram and U. Jayashree and Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/sbvj/fulltext/2025/01000/anaesthesia_management_of_a_primigravida_with.10.aspx}, doi = {10.4103/sbvj.sbvj_12_25}, issn = {2581-6039}, year = {2025}, date = {2025-03-23}, urldate = {2025-01-01}, journal = {SBV Journal of Basic, Clinical and Applied Health Science}, volume = {8}, issue = {1}, pages = {30–32}, publisher = {Wolters Kluwer Health}, abstract = {Scoliosis is a condition which could be congenital or acquired associated with other system involvement mainly cardiopulmonary and nervous system based on the level and extent of involvement. We report a case of 22-year-old primigravida with severe thoracolumbar scoliosis scheduled for elective lower segment cesarean section. The anesthetic management was under subarachnoid block without any sedation, and it was uneventful.}, keywords = {Anesthesiology, Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025c, title = {Cytotoxic edema of bilateral semicentrum ovale in uremic encephalopathy: a rare radiological entity}, author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka}, url = {https://sciencevolks.com/neurology/pdf/SVOA-NE-06-009.pdf}, doi = {10.58624/SVOANE.2025.06.009}, issn = {2753-9180}, year = {2025}, date = {2025-03-21}, urldate = {2025-03-21}, journal = {SVOA Neurology}, volume = {6}, issue = {2}, pages = {47-49}, abstract = {Uremic encephalopathy can mimic clinically and radiologically like a stroke. The presence of cytotoxic edema in bilateral semicentrum ovale without involvement of basal ganglion is uncommon in uremic encephalopathy in a diabetic patient. Here we demonstrate the rare white matter radiological subtype of uremic encephalopathy in a 48-year-old woman with chronic kidney disease.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025d, title = {Acute migraine: an overview}, author = {Sandhya Manorenj}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/13681/8304}, doi = {10.18203/2394-6040.ijcmph20250952}, issn = {2394-6032}, year = {2025}, date = {2025-03-19}, urldate = {2025-03-19}, journal = {International Journal of Community Medicine and Public Health}, volume = {12}, issue = {4}, pages = {1952-1964}, abstract = {Migraine is a primary headache disorder that affects people of all ages. It is the second most common type of headache disorder after tension headache. Migraine headache usually begins in adolescence, peak in the third decade of life, and becomes less frequent and less severe in later decades. Migraine affects women three times more often than men. Migraine can be very debilitating and can significantly impair an individual's ability to perform daily activities. Creating a clinical review on acute migraine and its management, using a pragmatic approach based on recent advances. The author reviewed the available literature on migraine and identified relevant articles through a literature search in the PubMed database to create this review. Migraine diagnosis is based on clinical examination and medical history, and imaging is usually not required. There are two main types of pharmacological treatment for migraine: abortive treatment to stop acute attacks and prophylactic treatment or preventive medication to reduce the frequency and severity of attacks. The treatment of migraine is constantly improving with new target-specific treatments, neuromodulation devices, and non-oral formulations of established medicines. This comprehensive review focuses on recent guidelines, newer approved drugs, and emerging therapies for managing acute migraine. }, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Bangi_2025, title = {A study of serum magnesium levels in patients with acute myocardial infarction in the rural population of Vijayapura district}, author = {Sayed Mohammed Hussain Bangi and Mohammed Hidayathulla and Abhishek Golla and Syeda Tasneem Kausar and Parvaiz Kadloor}, url = {https://ijcva.org/pdf/1fe4afca-adad-4137-be7c-36a5e5ab6910/articles/ijca.2024.96268/23-28.pdf}, doi = {10.4274/ijca.2024.96268}, issn = {2405-819X}, year = {2025}, date = {2025-03-18}, urldate = {2025-03-18}, journal = {International Journal of Cardiovascular Academy}, volume = {11}, issue = {1}, pages = {23-28}, abstract = {Background and Aim: Magnesium is an essential element for the proper functioning and regulation of cardiovascular physiology. It acts as a vital helper molecule in various enzyme systems and is involved in multiple cardiovascular processes. These processes include intracardiac conduction, myocardial contraction, atherogenesis, thrombosis, regulation of vascular tone, and the proliferation and migration of endothelial cells and vascular smooth muscle. The aim of this study was to evaluate the relationship between serum magnesium concentration and their correlation with complications and in-hospital outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: This observational study included patients who were admitted to a tertiary care centre in India from December 2019 to September 2021. A total of 100 patients with AMI were enrolled in the study. Serum magnesium concentration was assessed using the calmagite method. The patients were followed up for 7 days during their hospitalization to monitor complications and in-hospital outcomes. Results:The serum magnesium concentration was between 1.1 mg/dL and 4.0 mg/dL. There were 28 patients with hypomagnesemia and 11 patients with hypermagnesemia. The study population consisted of 57% male, and the majority of patients were in the age group of 60-80 years (38%). A typical clinical presentation was observed in 61% of the patients, while 39% of patients displayed an atypical clinical presentation. Higher proportions of patients with typical clinical presentation were significantly observed to have hypomagnesemia (P = 0.037). Among the total patient population, 20% experienced QT-prolongation in our study. Patients with hypomagnesemia experienced more complications, but patients with hypermagnesemia were associated with an increased rate of mortality. Conclusion: In patients with AMI, hypomagnesemia was associated with an increased incidence of complications. Conversely, hypermagnesemia was linked to increased mortality among patients.}, keywords = {Anatomy, Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025i, title = {I-Beam sign in progressive supranuclear palsy}, author = {Sandhya Manorenj and Chillapuram Shashanka}, url = {https://journals.lww.com/neur/fulltext/2025/03000/i_beam_sign_in_progressive_supranuclear_palsy.20.aspx}, doi = {10.4103/neurol-india.neurol-india-d-24-00101}, issn = {0028-3886}, year = {2025}, date = {2025-03-01}, urldate = {2025-03-01}, journal = {Neurology India}, volume = {73}, number = {pmid40176225}, issue = {2}, pages = {330-331}, abstract = {Background: Postural instability occurs in both progressive supranuclear palsy (PSP) and idiopathic Parkinson’s disease (IPD). Objective: Testing for postural instability using a pull test helps to differentiate IPD from PSP based on the presence of an I-beam sign in the latter. Methods and Materials: Here, we demonstrate the I-beam sign in a 65-year-old lady who presented with initial marked postural instability. Results: In PSP, postural instability occurs early. Here, we found that in patients with PSP on the backward pull test, they fall without taking a single step, like a building falls without an I-beam. This sign is called I-beam sign. In patients with IPD, this sign is absent as they take one or a few steps before falling. Clinical examination showed mild restriction of upward gaze, and there was radiological evidence of midbrain atrophy. The present case was diagnosed as PSP with a postural instability variant. Conclusion: The presence of the I-beam sign in patients with Parkinsonism suggests PSP.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Kari_2025, title = {A dosimetric analysis on supine and prone positions in carcinoma cervix patients using intensity-modulated radiotherapy at a tertiary cancer centre}, author = {Nagasai Divya Kari and Mohd. Asimuddin and Sai Teja Adepu and M. Ramakrishna}, url = {https://jccpractice.com/article/a-dosimetric-analysis-on-supine-and-prone-positions-in-carcinoma-cervix-patients-using-intensity-modulated-radiotherapy-at-a-tertiary-cancer-centre-585/}, doi = {10.61336/jccp/25-02.63}, issn = {2457-7200}, year = {2025}, date = {2025-02-28}, urldate = {2025-02-28}, journal = {Journal of Contemporary Clinical Practice}, volume = {11}, issue = {2}, pages = {477-488}, abstract = {Background: Radiotherapy remains a cornerstone in the management of carcinoma cervix, with patient positioning playing a crucial role in dosimetric outcomes. Proper positioning during radiotherapy can significantly influence the dose distribution to the target volumes and organs at risk (OARs), potentially impacting treatment efficacy and toxicity. Aim: To evaluate and compare the dosimetric parameters of supine and prone positions in carcinoma cervix patients undergoing intensity-modulated radiotherapy (IMRT) at a tertiary cancer center, with a focus on optimizing target volume coverage and minimizing radiation exposure to organs at risk. Methods and Materials: This was a prospective study conducted at MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, over a period of 24 months. A total of 25 patients with carcinoma cervix were enrolled. Patients included in the study were aged 30–65 years, with histopathologically confirmed stage IB-IIIB carcinoma cervix (FIGO guidelines), and a performance status of 1–3 as per Eastern Cooperative Oncology Group criteria. All patients had normal blood, liver, and kidney function tests. Patients with stage IA, IIIC, or IV disease, distant metastasis, poor performance status, synchronous malignancies, or HIV positivity were excluded. Radiotherapy planning involved CT simulation scans in both supine and prone positions using immobilization devices. Target volumes and OARs were delineated according to international guidelines, and dosimetric parameters were analyzed for both positions. Results: The mean PTV volume was slightly higher in the prone position (1616.68 ± 172.85 cc) compared to the supine position (1561 ± 186.50 cc). Dose coverage was comparable, with PTV 95% being 95.896% in the prone position and 97.669% in the supine position. However, prone positioning provided better sparing of the small bowel, with lower dose-volume metrics across all thresholds (e.g., V50: prone 1.7%, supine 5.7%). The bladder dose metrics were similar, with V10 being 100% in both positions, but V45 was slightly lower in the prone position (43%) compared to the supine position (50%). For the rectum, prone positioning significantly reduced exposure at higher doses (e.g., V50: prone 4.5%, supine 7.4%). Conclusion: The prone position demonstrated superior sparing of the small bowel and rectum while maintaining comparable dose coverage for target volumes and bladder. These findings suggest that prone positioning can enhance IMRT treatment efficacy and reduce toxicity in carcinoma cervix patients, offering a potentially improved therapeutic ratio.}, keywords = {Radiation Oncology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Study of coronary arteries in human cadavers: A cross-sectional study}, author = {Kannan Subramanian and Syeda Tasneem Kauser and Mohammed Hidayathullah and Priyanka Bhaskar}, url = {http://impactfactor.org/PDF/IJCPR/17/IJCPR,Vol17,Issue2,Article109.pdf}, issn = {2961-6042}, year = {2025}, date = {2025-02-11}, journal = {International Journal of Current Pharmaceutical Review and Research}, volume = {17}, issue = {2}, pages = {665-671}, abstract = {Introduction: The word ‘coronary’ is derived from the Latin word co-ro-ne. “Corona” meaning “Crown”. The coronary arteries are the main blood supply to the heart and are known for its variations in both its origin as well as its branching pattern. The right coronary artery most commonly arises from the right aortic sinus and the left coronary artery arises from the left posterior aortic sinus. Anomalous origin of the coronaries and its branching pattern have been associated with increased incidence of coronary vascular events. This study is a cross-sectional study done in 60 cadaveric hearts to study the origin and variations in the coronary arteries. Materials and Methods: Randomly selected 60 formalin fixed hearts (preserved heart specimens and hearts from cadavers which were used for dissection teaching) were obtained from the Department of Anatomy. Meticulous dissection was done and the origin along with the course and branching of both the right and left coronary arteries and the coronary dominance were noted. Conclusion: The coronary artery disease is one of the major cause of death. Both sedentary and stressful type of lifestyle is a risk factor. Coronary dominance is important because inferior wall myocardial infarctions are common. The knowledge of the origin, branching pattern and the coronary dominance gives an insight to the cardiologists while performing angiography for more comprehensive treatment of the patients with coronary artery disease.}, keywords = {Anatomy, Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025, title = {Diaphragmatic myoclonus effectively treated with lacosamide: a very rare phenomenon of belly dancer syndrome}, author = {Sandhya Manorenj and Bushra Naaz and Manju Madhavan}, url = {https://journals.lww.com/neur/fulltext/2025/01000/diaphragmatic_myoclonus_effectively_treated_with.26.aspx}, doi = {10.4103/neurol-india.Neurol-India-D-23-00458}, issn = {0028-3886}, year = {2025}, date = {2025-02-07}, urldate = {2025-02-07}, journal = {Neurology India}, volume = {73}, issue = {1}, pages = {149-151}, abstract = {Diaphragmatic myoclonus, also called diaphragmatic flutter, has characteristic abdominal movements resembling those of a belly dancer; hence, it is also called belly dancer syndrome (BDS). BDS is characterized by high-frequency involuntary diaphragmatic contractions. BDS can occur due to a lesion anywhere in the pathway for diaphragmatic control, from the motor cortex to the neural supply to the diaphragm. Here we report a 21-year-old girl who presented with acute-onset abdominal movements of 5 days duration. Clinical examination showed abdominal jerky movements with preserved awareness. Electroencephalograms (EEG) showed polyspike wave discharges consistent with cortical myoclonus. These abdominal myoclonic jerks disappeared dramatically on treatment with lacosamide, a third-generation antiepileptic drug. There are few case reports of BDS in the literature with a cortical myoclonus origin instead of the widely described segmental myoclonus form. The case also highlights the efficacy of lacosamide in treating diaphragmatic myoclonus jerk in young adults.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Aziz_2025, title = {Evaluation of perceptions of student presenters, student audience and faculty towards seminars as teaching learning method in medical education}, author = { Nusrat Aziz and Farha Tarannum and Neeraj Sadiq and Sheema Khan and Shams Khan}, url = {https://jmas.in/?mno=226537}, doi = {10.5455/jmas.226537}, issn = {2231-1696}, year = {2025}, date = {2025-01-31}, urldate = {2025-01-01}, journal = {Journal of Medical and Allied Sciences}, volume = {15}, issue = {1}, pages = {56-63}, publisher = {Deccan College of Medical Sciences}, abstract = {Student led seminars as a pedagogical method is a type of active learning involving researching, organizing, reflection and presenting it in the most comprehensive way. In recent times with the encouragement of active learning, student led seminars has become a part of medical curriculum. The aim of this study was to explore perceptions of students and faculty towards it. The study was done in 1st year MBBS medical students and faculty members. Three seminars were conducted with 14 students in each seminar as presenters. Perceptions of presenters, student audience and faculty towards seminars were taken with a questionnaire with Likert scale with scoring from 12-60. All respondents agreed that seminars were more interesting, motivating, increase public speaking, remove stage fear and is a good way of learning. Student audience had low perception of seminars being helpful in self-directed learning, worth the effort and helpful in longer retention of knowledge which the student presenters perceived otherwise and the difference was statistically significant. All the respondents had low perception on seminars not being time consuming, does not require more effort and are better than lectures. The respondents have mostly a positive perception of student led seminars with Likert score of 51.9, 48 and 46.4 for seminar presenters, faculty and student audience respectively. The students and the faculty should be educated about the benefits of active learning like seminar presentations and encouraged to conduct and participate in seminar presentations as it facilitates in attainment of, in addition to knowledge, a complete professional development of the future doctor.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025c, title = {Mesentric cyst with a twist}, author = { Juveria Fatima and Shaila Tasneem and Farha Naaz and Naushaba Tazeen and Idrees Akhtar Afroze and Syed Asif Shah Harooni}, url = {https://jmas.in/fulltext/154-1722832055.pdf?1755672275}, doi = {10.5455/jmas.214286}, issn = {2231-1696}, year = {2025}, date = {2025-01-31}, urldate = {2025-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {15}, issue = {1}, pages = {88-91}, publisher = {Deccan College of Medical Sciences}, abstract = {With an incidence rate of 0.1-0.3% gastrointestinal stromal tumors (GIST) are rare to be found in extraintestinal locations known as extraintestinal GIST (EGIST). Mesenchymal in origin, they arise from interstitial cells of Cajal, a part of gastrointestinal autonomic nervous system (ANS). It is more common in males than females. GIST is mainly seen in stomach followed by small bowel, colon, rectum and esophagus. Incidence of EGIST is less than 1%. Patients with neurofibromatosis-1 has increased incidence of GIST. It can also present as Carney-Stratakis syndrome. GIST less than 2 cm is usually asymptomatic while GIST more than 2 cm presents with unexplained growth of abdomen, nausea, anemia, difficulty in swallowing, loss of appetite and weight loss. Herein we present a case of 31-yr old female, who presented with complaints of intermittent abdominal pain and was evaluated for infertility. Abdominal ultrasonography (USG) revealed cystic mass of mesentery. Computed tomography (CT) scan abdomen confirmed a cystic lesion with central necrosis arising from jejunal loops. Surgical excision of mesenteric cyst was performed and histopathological diagnosis of gastrointestinal tumor was given. Thus, high index of suspicion is required on part of pathologist to expect an EGIST mimicking as a mesenteric cyst.}, keywords = {General Surgery, No Department, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Mujeeb_2025, title = {Cartilaginous metaplasia of thyroid nodule}, author = { Madeeha Mujeeb and Jasmeen Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze and Imtiyaz Ahmed Khan}, url = {https://jmas.in/fulltext/154-1723005195.pdf?1752816740}, doi = {10.5455/jmas.214579}, issn = {2231-1696}, year = {2025}, date = {2025-01-31}, urldate = {2025-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {15}, issue = {1}, pages = {92-94}, publisher = {Deccan College of Medical Sciences}, abstract = {Adenomatous goiter is the most common form of thyroid disease. Although degenerative changes like fibrosis, calcification, cystic changes and hemorrhagic tissue are commonly found, cartilaginous metaplasia is an unusual phenomenon in the thyroid gland. Heterotopic cartilage formation is a very rare finding in both neoplastic and non-neoplastic lesions. Only 2 cases have been reported so far. Here we present a case of a 65-year-old female who presented with a midline swelling in her neck for 2 months associated with difficulty in swallowing. The lymph nodes were not palpable and there were no pressure symptoms. Ultrasonography was suggestive of thyromegaly with large goiterous change in left lobe and isthmus of thyroid. Fine Needle Aspiration Cytology (FNAC) revealed Bethesda Category I lesion. The patient underwent left hemi-thyroidectomy. Microscopy revealed encapsulated lesions composed of variable-sized follicles filled with colloid. Cystic areas lined by benign follicular cells showing foci of cartilage were also observed. Consistent with diagnosis of adenomatoid goiter with cartilaginous metaplasia. This case shows a rare histopathological change in the thyroid nodular lesions.}, keywords = {No Department, Otorhinolaryngology, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Farzeen_2025, title = {Exploring a rare entity: Myxoid liposarcoma on anterior abdominal wall}, author = { Mehrina Farzeen and Sumaiya Shireen and Naushaba Tazeen and Idrees Akhtar Afroze and Syed Asif Shah Harooni}, url = {https://jmas.in/?mno=215424}, doi = {10.5455/jmas.215424}, issn = {2231-1696}, year = {2025}, date = {2025-01-31}, urldate = {2025-01-01}, journal = {Journal of Medical and Allied Sciences}, volume = {15}, issue = {1}, pages = {95-98}, publisher = {Deccan College of Medical Sciences}, abstract = {Myxoid liposarcoma is a soft tissue tumor. Out of all the malignant tumors, soft tissue tumors account for less than 1%, in which liposarcoma is the most common type of soft tissue tumor. The common site for liposarcoma is extremities and retroperitonium and on abdominal wall is exceptionally rare with only 22 cases reported so far. We report a case of 56 year old male patient presenting with anterior abdominal wall mass in left hypochondriac region of 6 months duration. There was no pain or discharge associated with it. On clinical examination, the mass was located on left upper quadrant of abdomen. Abdominal ultrasonography revealed well defined, hypoechoic, space occupying lesion. FNAC revealed scant fibroblast tissue. Trucut biopsy was advised. Radiological, clinical and cytological investigations were non- specific. An excision biopsy was performed and the sample was sent for histopathological examination. Gross examination revealed well circumscribed nodular myxoid mass, which was grey white in color. Microscopic examination revealed mesenchymal cells with myxoid rich stroma and cells show signet ring configuration. Pathological evaluation of surgical specimen is the gold standard for diagnosis. Complete excision with clear margin is the mainstay of treatment in view of its local recurrence. We report this case as myxoid liposarcomas are rarely seen in the clinic, here it has presented on an extremely unusual site, anterior abdominal wall.}, keywords = {General Surgery, No Department, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025d, title = {Renal cell carcinomas’ hidden challenge: sarcomatoid differentiation uncovered}, author = {Syeda Yousufa Husna Fatima and Hafeza Farha Syeda and Naushaba Tazeen and Idrees Akhtar Afroze and Mohammed Abdul Majid Adil}, url = {https://jmas.in/fulltext/154-1723478384.pdf?1755843299}, doi = {10.5455/jmas.215330}, issn = {2231-1696}, year = {2025}, date = {2025-01-31}, urldate = {2025-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {15}, issue = {1}, pages = {99-102}, publisher = {Deccan College of Medical Sciences}, keywords = {No Department, Pathology, Urology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025f, title = {Hemophagocytic lymphohistiocytosis: a clinical overview and case study}, author = {Zohra Fatima and Vivek Vijayrao Bhaganagare and Owaise Mohammed and Mariyah Amjad and Syeda Ayesha Siddiqua}, url = {https://www.msjonline.org/index.php/ijrms/article/view/14656/9378}, doi = {10.18203/2320-6012.ijrms20250277}, issn = {2320-6012}, year = {2025}, date = {2025-01-30}, urldate = {2025-01-30}, journal = {International Journal of Research in Medical Sciences}, volume = {13}, issue = {2}, pages = {891-896}, abstract = {Hemophagocytic lymphohistiocytosis (HLH) is a rare, potentially life-threatening hyperinflammatory syndrome resulting from excessive immune activation. It is broadly classified into primary (genetic) and secondary (acquired) forms, with secondary HLH often triggered by infections, malignancies, or autoimmune diseases. The condition presents significant diagnostic challenges due to overlapping features with other systemic inflammatory disorders and sepsis. This report describes a pediatric case of HLH associated with a bacterial infection, highlighting the importance of timely diagnosis and treatment to improve outcomes. A 9-year-old female presented with persistent fever, abdominal pain, distension, facial edema, hepatosplenomegaly, and pancytopenia. Laboratory investigations revealed hyperferritinemia (18,500 ng/ml), hypertriglyceridemia (450 mg/dl), and hypofibrinogenemia (1.2 g/l). Bone marrow aspirate demonstrated hemophagocytosis. Blood cultures identified Klebsiella pneumoniae as the infectious trigger. The patient met six of the eight HLH-2009 diagnostic criteria, confirming the diagnosis of secondary HLH. Treatment included intravenous dexamethasone and immunoglobulin (IVIG), along with supportive care. The patient responded well, with clinical improvement and normalization of laboratory parameters. Genetic evaluation was done to exclude primary HLH and it turned out to be PRF1 gene. This case underscores the critical need for early recognition of HLH in patients presenting with fever, cytopenias, and elevated inflammatory markers. Adherence to established diagnostic criteria and prompt initiation of treatment are essential to improving survival in this severe condition. The case also highlights the role of multidisciplinary care and genetic testing in ensuring optimal long-term management.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Haqqani_2025, title = {Anogenital papular acantholytic dyskeratosis with novel ATP2C1 mutation treated with tacrolimus and doxycycline}, author = {Ruhi Haqqani and Nayeem Sadath Haneef and Sidra Rana and Suchetha Reddy and Nasar Khaja }, url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC12270401/pdf/IDOJ-16-639.pdf}, doi = {10.4103/idoj.idoj_291_24}, issn = {2229-5178 }, year = {2025}, date = {2025-01-28}, urldate = {2025-01-28}, journal = {Indian Dermatology Online Journal}, volume = {16}, number = {pmid40688137}, issue = {4}, pages = {639-642}, abstract = {Not available}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Alla_2025, title = {Talimogene laherparepvec (T-VEC) as a treatment for melanoma: a systematic review}, author = {Sai Santhosha Mrudula Alla and Yogesh Tekuru and Moraboina Sai Lokesh and Deekshitha Alla and Patel Tvisha and Soujanya Tirupati and Aradhya Singh and Yeshala Tejaswini and Mariya Mahmood and Nanki Pratap Siingh and Bodipudi Vineetha}, url = {https://journals.sagepub.com/doi/10.1177/10781552241312920}, doi = {10.1177/10781552241312}, issn = {1078-1552}, year = {2025}, date = {2025-01-17}, urldate = {2025-01-17}, journal = {Journal of Oncology Pharmacy Practice}, volume = {31}, issue = {3}, pages = {481-487}, abstract = {Background and aims: Melanoma now presents an average risk of 1 in 50 in the Western world. Talimogene laherparepvec (T-VEC), an FDAapproved oncolytic virus derived from Herpes Simplex Virus type 1 (HSV-1), has proven effective in reducing morbidity and mortality from melanoma but causes adverse effects like chills, fever, exhaustion, and injection site discomfort. Research focuses on combining T-VEC with immune checkpoint inhibitors, such as pembrolizumab, to enhance its efficacy and broaden its application. Methods: A systematic search was conducted using PubMed, Scopus, Web of Science, Google Scholar, and ProMED, adhering to PRISMA guidelines. Results were tabulated and analyzed. Results: This review included 15 studies comprising nine cohorts, four case reports, a case series, and a randomized control trial, involving 779 melanoma patients in stages IIIB to IV, 58% of whom were male with a mean age of 65 years. Treatment duration with T-VEC averaged 35.07 weeks, with dosages ranging from 10^6 to 10^8 PFU/ml. The intervention yielded a mean DRR of 41.87% and an ORR of 62.2%. The most common side effect was chills, affecting 21.69% of participants. Pyrexia was reported by 20.41% of participants, followed by influenzalike illness (14.89%). Conclusion: T-VEC effectively improves ORR and DRR in melanoma patients. However, further research is needed on combination therapy prospects and its adverse effects.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Cerbulescu_2025, title = {Inflammatory markers and severity in COVID-19 patients with clostridioides difficile co-infection: a retrospective analysis including subgroups with diabetes, cancer, and elderly}, author = {Teodor Cerbulescu and Flavia Ignuta and Uma Shailendri Rayudu and Maliha Afra and Ovidiu Rosca and Adrian Vlad and Stana Loredana}, url = {https://www.mdpi.com/2227-9059/13/1/227}, doi = {10.3390/biomedicines13010227}, issn = {2227-9059 }, year = {2025}, date = {2025-01-17}, urldate = {2025-01-17}, journal = {Biomedicines}, volume = {13}, issue = {1}, pages = {227}, abstract = {Background and Objectives: The interplay of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and Clostridioides difficile infection (CDI) poses a critical clinical challenge. The resultant inflammatory milieu and its impact on outcomes remain incompletely understood, especially among vulnerable subgroups such as elderly patients, those with diabetes, and individuals with cancer. This study aimed to characterize inflammatory markers and composite inflammatory severity scores—such as Acute Physiology and Chronic Health Evaluation II (APACHE II), Confusion, Urea, Respiratory rate, Blood pressure, and age ≥ 65 years (CURB-65), National Early Warning Score (NEWS), and the Systemic Immune-Inflammation Index (SII)—in hospitalized Coronavirus Disease 2019 (COVID-19) patients with and without CDI, and to evaluate their prognostic implications across key clinical subgroups. Methods: We conducted a retrospective, single-center study of 240 hospitalized adults with Reverse Transcription Polymerase Chain Reaction (RT-PCR)-confirmed COVID-19 between February 2021 and March 2023. Of these, 98 had concurrent CDI. We collected baseline demographics, comorbidities, and laboratory parameters including C-reactive protein (CRP), Interleukin-6 (IL-6), ferritin, neutrophil and lymphocyte counts, albumin, platelet counts, and calculated indices (C-reactive protein to Albumin Ratio (CAR), Neutrophil-to-Lymphocyte Ratio (NLR), Prognostic Nutritional Index (PNI), SII). Patients were stratified by CDI status and analyzed for inflammatory marker distributions, severity scores (APACHE II, CURB-65, NEWS), and outcomes (Intensive Care Unit (ICU) admission, mechanical ventilation, mortality). Subgroup analyses included diabetes, elderly (≥65 years), and cancer patients. Statistical comparisons employed t-tests, chi-square tests, and logistic regression models. Results: Patients with CDI demonstrated significantly higher CRP, IL-6, SII, and CAR, coupled with lower albumin and PNI (p < 0.05). They also had elevated APACHE II, CURB-65, and NEWS scores. CDI-positive patients experienced increased ICU admission (38.8% vs. 20.5%), mechanical ventilation (24.5% vs. 12.9%), and mortality (22.4% vs. 10.6%, all p < 0.05). Subgroup analyses revealed more pronounced inflammatory derangements and worse outcomes in elderly, diabetic, and cancer patients with CDI. Conclusions: Concurrent CDI intensifies systemic inflammation and adverse clinical trajectories in hospitalized COVID-19 patients. Elevations in inflammatory markers and severity scores predict worse outcomes, especially in high-risk subgroups. Early recognition and targeted interventions, including infection control and supportive measures, may attenuate disease severity and improve patient survival.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Quadri_2025b, title = {Ultrasonography and pregnancy outcomes in cases of threatened abortion: a prospective observational study }, author = {Maryam Quadri}, url = {https://sjhresearchafrica.org/index.php/public-html/article/view/1448/1146}, doi = {10.51168/sjhrafrica.v5i12.1448}, issn = {2709-9997}, year = {2025}, date = {2025-01-09}, urldate = {2025-01-09}, journal = {Student’s Journal of Health Research Africa}, volume = {5}, issue = {12}, pages = {1-6}, abstract = {Background Threatened miscarriage, characterized by vaginal bleeding in early pregnancy, is a common complication that can significantly impact maternal and fetal outcomes. The ability to accurately predict pregnancy loss is crucial for effective clinical management. This study aims to evaluate the diagnostic performance of early ultrasound parameters in predicting pregnancy outcomes among women presenting with threatened miscarriage. Methods A prospective observational study was conducted involving 200 patients diagnosed with threatened miscarriage at a tertiary care center. Inclusion criteria included normal body mass index (BMI), a known last menstrual period (LMP), absence of cervical pathology, and a single viable pregnancy. Participants were divided into three groups: Group I (pregnancy loss), Group II (ongoing pregnancy), and Group III (control group). Ultrasound examinations were performed to assess fetal heart rate (FHR), gestational sac diameter (GSD), crown-rump length (CRL), and yolk sac diameter (YSD). Maternal and neonatal outcomes were recorded, and statistical analyses were performed using SPSS 10. Results Among the participants, 30% experienced pregnancy loss (Group I), while 70% continued their pregnancies (Group II). Significant differences were observed in ultrasound parameters, with Group I showing lower FHR (mean 98.2 bpm) and smaller GSD (mean 14.5 mm) compared to Groups II and III. The diagnostic performance of FHR <100 bpm and GSD <15 mm was found to be highly predictive of miscarriage, with sensitivities of 85% and 80%, respectively. Conclusion Early ultrasound parameters, particularly FHR and GSD, are valuable indicators of pregnancy outcomes in cases of threatened miscarriage. Their predictive capabilities can guide clinical management, allowing for closer monitoring and tailored interventions. Recommendations It is recommended that clinicians utilize early ultrasound assessments in women presenting with threatened miscarriages to improve pregnancy outcomes. Further studies are needed to validate these findings and explore additional markers that may enhance predictive accuracy.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2025b, title = {Acquired hepatocerebral degeneration and accumulation of manganese}, author = {Sandhya Manorenj and Sravan Kumar Marupaka}, url = {https://journals.lww.com/annalsofian/fulltext/2025/01000/acquired_hepatocerebral_degeneration_and.17.aspx}, doi = {10.4103/aian.aian_633_24}, issn = {0972-2327}, year = {2025}, date = {2025-01-02}, urldate = {2025-01-02}, journal = {Annals of Indian Academy of Neurology}, volume = {28}, issue = {1}, pages = {107-109}, abstract = {A 43-year-old man with chronic liver disease (CLD) due to alcoholism and hepatitis B virus (HBV) infection presented at the emergency department after experiencing a generalized tonic–clonic seizure and altered consciousness. He had been diagnosed with adult-onset epilepsy 3 years ago and was taking medication for seizure, which he had missed 2 days before. In addition, he was being treated with entecavir for the HBV infection.}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Tabassum_2025, title = {Diagnostic and prognostic significance of platelet indices and platelet lymphocyte ratio in covid vs dengue: an observational study}, author = {Asiya Tabassum and T. S. Shamshuddeen and Idrees Akhtar Afroze}, url = {https://journals.lww.com/jdrntruhs/fulltext/2025/01000/diagnostic_and_prognostic_significance_of_platelet.8.aspx}, doi = {10.4103/jdrntruhs.jdrntruhs_170_22}, issn = {2950-5348}, year = {2025}, date = {2025-01-01}, urldate = {2025-01-01}, journal = {Journal of Dr. NTR University of Health Sciences}, volume = {14}, issue = {1}, pages = {46-51}, abstract = {Background: Both SARS-CoV and dengue virus share the same symptoms in the early stages and at times causing misdiagnosis, coinfections are common creating difficulties for the health care workers. Aim: Efforts were made to utilize the hematology parameters, Mean platelet volume and Platelet lymphocyte ratio (PLR) in early segregation, diagnosis and predicting the severity and prognosis of the cases and to determine, if further investigations or referrals would be required. Material and Methods: Observational study was conducted with 100 confirmed cases of COVID-19 and dengue patients. Results: Patients with COVID-19 present with leucopenia or leucocytosis, with Lymphopenia as the most significant finding, Platelet counts were adequate but Mean platelet volume (MPV) is insignificant and increased levels of PLR are related with bad prognosis. In Dengue, the white blood cells (WBC) count shows progressive leucopenia with lymphocytic predominance with atypical lymphocytes, thrombocytopenia with increased MPV and decreased PLR help in early diagnosis of dengue infection. Conclusion: Complete blood count (CBC) is the most common and inexpensive test performed in patients and has capacity to segregate and diagnose Covid 19 and Dengue cases at an early stage so that isolation and prompt treatment can be started early, decreasing the lead time and help in combating the pandemic. PLR and MPV can be used to predict the prognosis and complications and have usefulness in monitoring treatment response. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Basith_2025, title = {Incidence and detection of M.tb multi-drug resistance in Hyderabad population using the PCR–sequence method}, author = {Mohammed Abdul Basith and Moid Mir Siddiq Ali and Sarwat Fatima and Aleem Ahmed Khan and M. Aleemuddin Naveed and Raja Nagarapu and Farah Bahmed}, url = {https://journals.lww.com/jdrntruhs/fulltext/2025/01000/incidence_and_detection_of_m_tb_multi_drug.9.aspx}, doi = {10.4103/jdrntruhs.jdrntruhs_155_23}, isbn = {2950-5348}, year = {2025}, date = {2025-01-01}, urldate = {2025-01-01}, journal = {Journal of Dr. NTR University of Health Sciences}, volume = {14}, issue = {1}, pages = {52-57}, abstract = {Introduction: Tuberculosis (TB) is a multifaceted disease caused by Mycobacterium tuberculosis ( M.tb) is a pathogenic bacterium, which poses to public health problem in both industrialized and developing countries. According to the World Health Organization, 8.8 million active cases of TB are diagnosed each year, and of these, almost 2 million die. Once thought to be under control, but TB infection levels are rising, and the threat is compounded by new, virulent, and drug-resistant strains. So we determine the Incidence and Detection of M.tb multi-drug resistance (MDR) in the Hyderabad population using the polymerase chain reaction (PCR)–Sequencing Method. Methodology: A prospective hospital-based study involving 60 patients was conducted for assessment of phenotypic conventional drug susceptibility testing combined with sequencing-based mutation screening, for increased sensitivity and identification of novel mutations in first-line M.tb drugs. Participants’ age ranged from >18 to rpoB and katG genes were amplified by using the designated primers and were sequenced to know the mutations and analyzed with reference sequences. Results: It has now been established that mutations in the rpoB gene and katG gene of M. tuberculosis are associated with resistance to Rifampicin and Isonazid, respectively. Present study, 67.5% of the non-responder group had a mutation at rpoB531 and katG315. 22.5% of the responder group had an Insertional mutation at rpoB513 and katG315. However, 4% of the non-responder group had a mutation at both rpoB codons 513 and 531 and katG codons 315 and 299. There are no mutations found in the control strain. Moreover, a novel mutation was also identified in this research where an extra Arginine was inserted at codon 513. Conclusion: We have shown the usefulness of our DNA sequencing strategy for drug susceptibility screening. Most MDR TB strains, which are resistant to both RIF and INH, are resistant to other antitubercular drugs.}, keywords = {Central Research Laboratory, Microbiology, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2025g, title = {Whispers of the ovary: a pathological journey through lymphangioma}, author = {Juveria Fatima and Naushaba Tazeen and Asiya Tabassum and Idrees Akhtar Afroze}, url = {https://journals.lww.com/tjima/fulltext/2025/01000/whispers_of_the_ovary__a_pathological_journey.14.aspx}, doi = {10.4103/tjima.tjima_15_25}, isbn = {3050-6158}, year = {2025}, date = {2025-01-01}, urldate = {2025-01-01}, journal = {Telangana Journal of IMA}, volume = {5}, issue = {1}, pages = {44-47}, abstract = {Lymphangioma of the ovary is an exceedingly rare benign tumor, characterized by the proliferation of lymphatic vessels. Typically presenting in childhood or early adulthood, these lesions can often be asymptomatic but may occasionally lead to abdominal pain, pelvic mass, or complications such as torsion or hemorrhage. Diagnosis is primarily achieved through imaging techniques such as ultrasound, computed tomography, or magnetic resonance imaging, which help differentiate lymphangiomas from other ovarian masses. Histopathological examination is essential for definitive diagnosis, revealing cystic spaces lined by the endothelial cells and a lymphatic-like structure. Management usually involves surgical intervention, with complete excision being the preferred treatment to prevent recurrence. Given the rarity of ovarian lymphangiomas, there is limited literature on the long-term outcomes; however, most cases report favorable prognoses following appropriate surgical resection. This abstract aims to summarize the clinical features, diagnostic approaches, and treatment options for ovarian lymphangioma while emphasizing the need for awareness of this rare entity among clinicians to facilitate timely diagnosis and intervention. Further studies are warranted to better understand the pathogenesis and optimal management strategies for this unusual tumor.}, keywords = {No Department, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Nimrah_2024, title = {Assessment of the living conditions in a rural setting through cross sectional study}, author = {Safia Nimrah and Shaik Sadiya Rahmath and Madhipati Sai Krishna and Sultan Rizwan Ahmad}, url = {https://medicopublication.com/index.php/ijphrd/article/view/20261/17776}, doi = {10.37506/sxz7xa71}, issn = {0976-0245}, year = {2024}, date = {2024-12-28}, urldate = {2024-12-28}, journal = {Indian Journal of Public Health Research & Development}, volume = {16}, issue = {1}, pages = {377-382}, abstract = {Background: An important part of a healthy community comprises healthy families. Living conditions play a crucial role in defining the well-being of the family. The quality of housing, access to basic amenities, environmental factors and the overall socio-economic status of the families have a direct impact on the family health. Methodology: This is a cross sectional study done based on the survey of 200 families based in Hasan Nagar, conducted by the students of Deccan College of Medical Sciences under the guidance of the department of community medicine. The families were surveyed based on a pre-formed questionnaire and the data was analysed using descriptive analysis. Conclusion: In this study of 200 families, 77% were nuclear families, 69.5% had pucca houses. Majority of the families 26.5% had 5 family members. In 45% of the families overcrowding was present. All of the houses had electricity supply. Separate kitchen was present in 77% of the houses. In 85% of families rice was the staple food. 88.5% used public refuse bins for disposal of solid waste and 96% used sewerage systems for liquid waste disposal. Latrine was present in 94% of the houses.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024g, title = {Efficacy and safety of tenecteplase versus alteplase in acute ischemic stroke: evidence from a South Indian cohort}, author = {Sandhya Manorenj and Maryam and Iqra Jahan and Syeda Noor Fatima and Yumna Fatima and Mir Wajahath Ali}, url = {https://rjn.com.ro/articles/2024.4/RJN_2024_4_Art-13.pdf}, doi = {10.37897/RJN.2024.4.13}, issn = {1843-8148}, year = {2024}, date = {2024-12-26}, urldate = {2024-12-26}, journal = {Romanian Journal of Neurology}, volume = {23}, issue = {4}, pages = {403-409}, abstract = {Background. Acute ischemic stroke (AIS) requires efficient thrombolytic therapy to re-establish vascular permeability and mitigate tissue damage. Alteplase and tenecteplase are prominent tissue plasminogen activators (tPAs) employed in this clinical scenario. This study compares these two agents, focusing on their efficacy, safety profiles, time parameters, and rates of re-hospitalization. Objectives. To compare the efficacy and safety of tenecteplase versus alteplase for treating acute ischemic stroke in South Indian patients: a prospective study. Methods. At a single center, we conducted a prospective, observational, non-interventional study of patients receiving thrombolytics alteplase or tenecteplase from November 2023 to July 2024, which included patients within a 4.5-hour window of symptom onset. The principal outcome of this study is to evaluate early neurological improvement using the clinical assessment scales – the National Institutes of Health Stroke Scale (NIHSS) at baseline and 24 hours, and the Modified Rankin Scale (mRS) at admission and 3 months. The secondary outcomes include the door-to-needle time (DTN) and assessing the need for re-hospitalization. Data was scrutinized using a t-test and median interquartile range (IQR). Results. The study enrolled 64 patients, 32 treated with alteplase and 32 with tenecteplase. Statistical significance was found for the efficacy of the drugs (NIHSS post-treatment p = 0.01 and mRS p = 0.002). The DTN and re-hospitalization were found to be non-significant. Conclusion. Both alteplase and tenecteplase efficiently manage AIS, with tenecteplase demonstrating advantages in early neurological improvement, ease of administration, and cost-effectiveness.}, keywords = {Deccan School of Pharmacy, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Khurram_2024, title = {A study of body fat distribution-in childhood obesity and its associated metabolic risk factors}, author = {Mir Sumsam Ali Khurram}, url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/6362/3918}, doi = {10.18203/2349-3291.ijcp20243850}, issn = {2349-3283}, year = {2024}, date = {2024-12-24}, urldate = {2024-12-24}, journal = {International Journal of Contemporary Pediatrics}, volume = {12}, issue = {1}, pages = {28-33}, abstract = {Background: The Objective of the present study was to find out fat distribution pattern in obese children between 6 to 12 years of age as compared to non-obese children of same age. Methods: A case control study was done between 1st July 2023 to 1st July 2024 on 138 children between 6 to 12 years of age group in Deccan College of Medical Sciences, Hyderabad, Telangana state. Ultra-sonographic measurement of fat thickness including maximum and minimum preperitoneal fat thickness, maximum and minimum abdominal subcutaneous fat, thickness at triceps and subscapular regions were determined in all participants. Fasting blood glucose was measured using enzymatic assay. Total cholesterol was measured by enzymatic assays. Results: Total 138 children were enrolled in the study. Out of 138 children included in study, the study population included 69 obese (35 females and 34 males) and 69 non-obese children (33 females and 36 males). When both groups were compared, weight, Body mass Index (BMI) and ultra-sonographic measurement of body fat thickness differed significantly. Conclusions: Obese children have high serum cholesterol, high serum triglyceride and high serum LDL levels as compared to non-obese children. In obese children, higher the fasting serum insulin level, more is the preperitoneal fat layer 5cm above the umbilicus with p-value of <0.05 which is significant.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Kulkarni_2024, title = {Attitude of caregivers, psychiatrists, and nurses toward coercive measures: an observational, survey-based comparative study}, author = {Sneha Kulkarni and M. Uma Shankar and Ravi Kumar Dabbiru and Ramsubba Reddy and Sireesha Srinivasa Rao and Minhajzafar Nasirabadi}, url = {https://journals.lww.com/tjpy/fulltext/2024/10020/attitude_of_caregivers,_psychiatrists,_and_nurses.9.aspx}, doi = {10.4103/tjp.tjp_4_24}, issn = {2455-8559}, year = {2024}, date = {2024-12-21}, urldate = {2024-12-21}, journal = {Telangana Journal of Psychiatry}, volume = {10}, issue = {2}, pages = {143-150}, abstract = {Objectives: The primary objective was to compare the attitude of health-care providers (psychiatrists and nursing staff) and caregivers. Materials and Methods: This prospective, survey-based study used the Staff Attitude to Coercion Scale, Morisky Medication Adherence Rating Scale, Oslo Social Support Scale, and the Modified Overt Aggression Scale. Results: Participants (326) included psychiatrists (32.51%), staff nurses (35.58%), and caregivers (31.90%). Health-care professionals scored higher in offense and safety subscale (psychiatrists 3.2 and 5.55; nurses 3.12 and 5.65) compared to caregivers (2.46 and 5.10). In coercion as treatment subscale, caregivers scored least (0.78) (psychiatrists 1.15, nurses 1.92). The difference in these subscales was statistically significant (P = 0.001). There was no significant influence of social support and level of education of caregivers on the use of physical restraint. Of 104 patients, 58.65% were brought with physical restraint. Treatment compliance (n = 85) in stabilized patients was 84.7%. Conclusion: According to health-care providers, the use of coercion was offensive; coercion can be reduced by improving the resources and giving more personal time. All groups acknowledged that coercion infringes on patients’ human rights but supported its use when necessary for ensuring patient care and safety in the environment.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Adepu_2025, title = {A study on information needs, evaluation of quality of life and pain assessment in patients with metastatic cancer receiving palliative radiotherapy}, author = {Sai Teja Adepu and Nagasai Divya Kari and Mohd. Asimuddin and M. Ramakrishna and Kanugula Sravanthi}, url = {https://jccpractice.com/article/a-study-on-information-needs-evaluation-of-quality-of-life-and-pain-assessment-in-patients-with-metastatic-cancer-receiving-palliative-radiotherapy-232/}, doi = {10.18683/jccp.2024.1091/2.36}, issn = {2457-7200}, year = {2024}, date = {2024-12-21}, urldate = {2024-12-21}, journal = {Journal of Contemporary Clinical Practice}, volume = {10}, issue = {2}, pages = {256-263}, abstract = {Background: Metastatic cancer often leads to debilitating symptoms, including pain and compromised quality of life (QoL). Palliative radiotherapy (RT) serves as a critical intervention to alleviate symptoms and enhance QoL. Understanding patient-specific information needs, assessing pain, and evaluating QoL pre- and post-RT are essential for optimizing patient-centered care. Aim: This study aims to assess the information needs, pain levels, and QoL of patients with metastatic cancer undergoing palliative RT and to evaluate the changes in QoL and pain scores before and after RT. Materials and Methods: A prospective study was conducted from 2019 to 2020 at MNJ Institute of Oncology and Regional Cancer Centre, involving 50 patients with histologically confirmed metastatic cancers (age 18–75, ECOG performance score 1–3). Patients completed Cassileth’s Information Needs Questionnaire to assess information requirements, the Numeric Pain Scale for pain evaluation, and the EORTC QLQ-C30 questionnaire for QoL assessment before RT and one month after its completion. Statistical analysis was performed using SPSS version 22.0. Results: The majority (88%) of patients expressed a strong need to know whether the illness was cancer, and 82% wanted to know the specific medical name of their illness. Pain scores significantly improved after RT (mean pain score pre-RT: 59.42; post-RT: 32.4; p=0.000). QoL assessment showed statistically significant improvements in Global Health Status (p=0.032), Physical Functioning (p=0.003), Role Functioning (p=0.002), Emotional Functioning (p=0.016), and Cognitive Functioning (p=0.008). Symptom scales showed significant improvement in fatigue (p=0.000), pain (p=0.000), dyspnea (p=0.034), appetite loss (p=0.047), diarrhea (p=0.009), and insomnia (p=0.018). Constipation worsened slightly, though not significantly (p=0.497). Conclusion: Cancer patients consistently desired comprehensive information about their diagnosis and treatment options, regardless of age, education, socioeconomic status, or prognosis. Among those with metastatic cancers, palliative radiotherapy significantly improved quality of life, particularly by alleviating pain, the most common symptom.}, keywords = {Radiation Oncology}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2024d, title = {A pseudo guillain barre syndrome (GBS) presentation of sjogren’s syndrome}, author = {Reshma Sultana Shaik and Sandhya Manorenj}, url = {https://journals.lww.com/neur/fulltext/2024/11000/a_pseudo_guillain_barre_syndrome__gbs_.29.aspx}, doi = {10.4103/ni.ni_4_23}, issn = {0028-3886}, year = {2024}, date = {2024-12-17}, urldate = {2024-12-17}, journal = {Neurology India}, volume = {72}, issue = {6}, pages = {1283-1284}, abstract = {NA}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Rozati_2025, title = {Assessment of embryo quality and conception rate in patients undergoing invitro fertilization/intracytoplasmic sperm injection with different indications in assisted reproductive technology}, author = {Roya Rozati and Wajeeda Tabassum and Mohammed Sarosh Ahmed and Vikram Aiman Ayapati and Ayapati Gautam Mehdi and Taalia Nazeer Ahmed and Sumaiya Nayela}, url = {https://juniperpublishers.com/jgwh/JGWH.MS.ID.556207.php}, doi = {10.19080/jgwh.2025.27.556207}, issn = {2474-7602}, year = {2024}, date = {2024-12-17}, urldate = {2024-12-17}, journal = {Journal of Gynecology and Womens Health}, volume = {27}, issue = {2}, pages = {556207}, abstract = {Objective: The aim of this study is to assess embryo quality and Conception rate in patients undergoing Invitro Fertilization/intra-Cytoplasmic Sperm Injection (ICSI) outcomes (fertilization rate, embryo quality, pregnancy rate, and live birth rate) for couples with Endometriosis, PCOS, Male Infertility, Tubal Factor and unexplained infertility. Methods: This is a retrospective study of 150 IVF/ ICSI Cases performed between 2018 and 2023 to compare outcomes in couples with PCOS, Endometriosis, Male Infertility, Tubal Factor, and unexplained infertility with about 4-5 cycles on average. Infertile couples were divided into 5 groups in each 30 cases were divided.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2024b, title = {Seroprevalence of SARS-CoV-2 IgG antibodies in health care workers and the associated risk factors during the covid-19 pandemic period at a tertiary care heatlh center in South India}, author = {Sarwat Fatima and Ahmed Abdul Bari Hazari and Deepika Handa}, url = {https://pdf.ipinnovative.com/pdf/23488}, doi = {10.18231/j.ijmmtd.2024.056 }, issn = {2581-4753 }, year = {2024}, date = {2024-12-12}, urldate = {2024-12-12}, journal = {IP International Journal of Medical Microbiology and Tropical Diseases}, volume = {10}, issue = {4}, pages = {329-336}, abstract = {Background: Most of the published studies across the globe so far have demonstrated a highly variable seroprevalence rate of SARS-CoV-2 IgG antibodies in health care workers [HCW’s] during the pandemic period. Multiple risk factors were studied that influenced the seropositivity. Aim & Objective: The primary aim of the study was to determine the seroprevalence of SARS-CoV-2 IgG in HCW’s in local settings during the pandemic period. The secondary objective was to categorize the HCW’s based on the history of symptoms of covid-19 and also to evaluate the relation between the various risk factors and seropositivity amongst the HCW’s. Materials and Methods: A cross sectional prospective study was conducted on health care workers at a tertiary care hospital in Telangana state during the pandemic period between March to April 2021. Following enrollment and verbal consent from the participants descriptive data was collected using a validated questionnaire. SARS-CoV-2 IgG antibodies estimation was done using ELFA technology after obtaining IERB clearance. Results: Of the 230 enrolled participants 141 [61.30%] fulfilled the inclusion criteria. The overall SARS-CoV-2 IgG seropositivity in the present study was 48 [34.04%]. Of the 72 [51.06%] symptomatic HCW’s, 19 [26.38%] were seropositive and of the 69 [48.93%] asymptomatic, 29 [42.02%] were seropositive. Among the various risk factors studied none were found to be significantly associated with seropositivity. Conclusion: in the present study a greater number of asymptomatic HCW’s were found seropositive which could be due to several of the reasons discussed below one being silent transmission of the virus and demands further enquiry into the cause by improved research methodology.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2024b, title = {ICD-10 health profiling of school-attending children in the field practice area of a medical college in south India: a cross-sectional study }, author = {Mohammed Sarosh Ahmed and Mohd. Ibrahim Khan and Fawwad M. Shaikh and Sultan Rizwan Ahmad}, url = {https://nicpd.ac.in/ojs-/index.php/gjmedph/article/view/4098/3190}, issn = {2277-9604}, year = {2024}, date = {2024-12-04}, urldate = {2024-12-04}, journal = {Global Journal of Medicine & Public Health }, volume = {13}, issue = {5}, pages = {1-7}, abstract = {Background: The health of school children is crucial for academic performance and overall well-being, influencing their capacity to learn and thrive. Understanding the health dynamics in school settings can help mitigate long term public health issues. This study aims to ascertain the health status of school children residing in slum areas of an urban locality in the southern part of India using International Classification of Diseases-10 (ICD-10) codes, which can inform policies and interventions to promote better health outcomes and educational attainment. Method: A cross-sectional study was conducted in a school in urban slum of Hyderabad city to evaluate the health status of school children. Data were collected using a standardized proforma, capturing information such as student demographics (name, age, sex, grade), anthropometry and physical examination findings. Results: The study encompassed 3,157 children, comprising 1,840 girls (58%) and 1,317 boys (42%), aged between 5 to 16 years. The mean ± SD age of menarche was found to be 13.1 ± 1.2 years. Among the participants, 62.2% reported at least one health-related issue, with dental caries being the most prevalent (38.1%), followed by skin problems (14.3%) and malnutrition (9.4%). Conclusion: In this study, health problems were found to be more common in boys compared to girls. More than half of the children were suffering from at least one health-related issue. Regular school health checkups help to identify and prevent health complications.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Golla_2024, title = {Impact of diabetes on clinical characteristics and angiographic findings in young adults with ST-elevation myocardial infarction: a cross-sectional study}, author = {Abhishek Golla and Mohammed Hidayathulla and Sowmya Chavala and Rajashekar Reddy Gurrala and Sayed Mohammed Hussain Bangi}, url = {https://www.jcdr.net/articles/PDF/20401/75961_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_OM)_PFA(IS)_PN(IS).pdf}, doi = {10.7860/JCDR/2024/75961.20401}, isbn = {0973-709X}, year = {2024}, date = {2024-12-01}, urldate = {2024-12-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {18}, issue = {12}, pages = {OC01-OC04}, abstract = {Introduction: The prevalence of diabetes among young patients with ST-Elevation Myocardial Infarction (STEMI) is increasing, but its impact on this population remains understudied. Limited data on diabetes in young patients with STEMI exist. The presence of diabetes among young patients experiencing STEMI deserves special consideration, as it manifests with unique clinical patterns and can significantly impact their active lifestyle. Aim: To determine the effect of diabetes and associated clinical characteristics in young patients with STEMI. Materials and Methods: A cross-sectional study was conducted at a tertiary care centre in India between April 2018 and December 2019. Fifty-one STEMI patients aged below 40 years were enrolled and categorised into diabetic (n=23) and non diabetic (n=28) groups based on glycated haemoglobin (HbA1c) levels. Clinical characteristics, laboratory parameters and angiographic findings were compared between the groups. This study analysed continuous variables using Student’s t-test and Analysis of Variance (ANOVA) (expressed as mean±SD), and categorical variables using Chi-square or Fisher’s exact tests (shown as n, %). A p-value of < 0.05 was considered significant. Results: The mean age was 35.6±3.4 years, with 80.4% male predominance. Diabetic patients showed higher prevalence of dyslipidaemia (p-value=0.009), hypertension (p-value=0.043), and metabolic syndrome (p-value=0.002). They also exhibited significantly higher levels of total cholesterol, triglycerides and Low-Density Lipoprotein Cholesterol (LDL-C). Anterior Wall Myocardial Infarction (AWMI) was predominant in both groups (p-value=0.442). Single-Vessel Disease (SVD) was most common, but Triple-Vessel Disease (TVD) was observed exclusively in diabetic patients (p-value=0.198). The Left Anterior Descending (LAD) artery was the most involved vessel in both groups. Conclusion: Compared to non diabetic patients, young STEMI patients with diabetes demonstrated a more adverse cardiovascular risk profile and lipid abnormalities.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Iron folic acid deficiency in pregnant women with cleft lip and palate deformities}, author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/iron-folic-acid-deficiency-in-pregnant-women-with-cleft-lip-and-palate-deformities/NjAxNzg=/?is=1&b1=4&k=1}, issn = {2277-8179}, year = {2024}, date = {2024-11-30}, journal = {International Journal of Scientific Research}, volume = {13}, issue = {11}, pages = {82-84}, abstract = {The Orofacial clefts occur when the lips or the roof of the mouth do not fuse properly during the early weeks of pregnancy. There is strong evidence that periconceptional use of folic acid can prevent neural tube defects but its effect on oral clefts has generated debate. To identify factors associated with suboptimal periconceptional use of folic acid and its potential effect on oral clefts. The population-based infant cohort of the national Growing Up in Indian study, which consists of 10,134 9-month-old infants. Data collection comprised questionnaires conducted by interviewers with parents in parents' homes. Characteristics of mothers who did or did not take folic acid before and during pregnancy, as well as the effect of folic acid use on the prevalence of cleft lip and palate were recorded. The prevalence of cleft lip and palate was 1.92 (94% confidence interval [CI] = 1.21 to 2.88) per 500 9-month-olds. The odds ratio for cleft lip was 2.24-fold higher (92% CI = 1.11 to 8.10, P = 0.006) for infants of mothers who did not take folic acid during the first 3 months of pregnancy, when compared with those who did have a folate intake during the first trimester. Folic acid use was suboptimal in 32.2% (94% CI = 32.2 to 35.1) of the sample. These findings support the hypothesis that taking folic acid may partially prevent cleft lip and palate. They are particularly relevant for GPs, because they are usually the first port of call for women before and during early pregnancy.}, keywords = {Physiology, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Electrolytes imbalance in management of electrical burns}, author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/electrolytes-imbalance-in-management-of-electrical-burns/NDExNjA=/?is=1&b1=&k=}, issn = {2249-555X}, year = {2024}, date = {2024-11-30}, journal = {Indian Journal of Applied Research}, volume = {14}, issue = {11}, pages = {32-34}, abstract = {Aim of treatment is to achieve skin cover to prevent infection and to allow early mobilization. Electrical injuries are a relatively uncommon. Adult electrical injuries usually occur as an occupational hazard, whereas children are primarily injured accidentally. The spectrum of electrical injury is very broad, ranging from minimal injury to severe multi organ involvement, with both occult and delayed complications and death. This is a prospective study from OWAISI HOSPITAL & RESEARCH CENTRE, DECCAN COLLEGE OF MEDICAL SCIENCES, HYDERABAD. A total of 100 patients presenting from June 2023 to September 2024 were included. Patients were treated with surgical excision 21 (21.53 %), fasciotomy 16 (16.43 %), escharotomy 77 (77.62 %), and amputation 10 (10.21 %). In all patients debridement was performed. After follow-up, there was 6.64 % (6 patients) mortality. Minimal mortality may be due to less surface area involved or no visceral injury. Patients survived with morbidity due to amputation. Initial management of electrical burn is imperative to optimize function and minimize long-term scarring. However, further studies are required regarding flap repair and microsurgery to minimize the rate of amputation.}, keywords = {Physiology, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Hussaini_2024, title = {Analysis of pH, electrolytes and non-invasive respiratory support in COPD with elevated CO2}, author = {Madeeha Hussaini and Rida Minhaj and Nukala Aishwarya and Maanasa Kurapati and Yazan Al Khatib and Zehra Yousuf and Mohamedelfatihmusaab Ibrahim Mohamed and Rabia Azam and Hamza A. Orfali and Mohammed Abdul Mateen}, url = {https://www.bioinformation.net/020/9732063002001503.pdf}, doi = {10.6026/9732063002001503}, isbn = {0973-2063}, year = {2024}, date = {2024-11-30}, urldate = {2024-11-30}, journal = {Bioinformation}, volume = {20}, issue = {11}, pages = {1503-1507}, abstract = {The contributions of pH balance and electrolytes among patients with chronic obstructive pulmonary disease (COPD) experiencing hypercapnic exacerbations requiring non-invasive ventilation (NIV) are of interest. Hence, we used samples from 70 patients admitted in a tertiary care hospital from January to June 2023. The main variable analyzed was arterial blood gas data and serum electrolyte levels. A positive correlation between bicarbonate levels and PCO2 was found, with p < 0.01 and r = 0.74, indicating metabolic compensation for respiratory acidosis. NIV was required in the majority of patients: in 64.3%, values were higher for both PCO2 (52.3 ą 7.1 mmHg vs. 39.6 ą 4.3 mmHg) and bicarbonate levels (32.4 ą 4.8m Eq/L vs. 26.1 ą 3.1 m Eq/L; p < 0.01) in the NIV group. Thus, data highlights the role of monitoring PCO2 and bicarbonate in guiding the use of NIV and in a more secondary role to hypercapnia disturbances in electrolytes.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2024, title = {Vasculopathy and posterior circulation stroke after measles in two children}, author = {Mohammed Fahad Mohiuddin and Sandhya Manorenj and Shalini Akunuri and Ahlaam Arif}, url = {https://journals.lww.com/neur/fulltext/9900/vasculopathy_and_posterior_circulation_stroke.5.aspx}, doi = {10.4103/neurol-india.neurol-india-d-24-00502}, issn = {1998-4022}, year = {2024}, date = {2024-11-29}, urldate = {2024-11-01}, journal = {Neurology India}, publisher = {Medknow}, keywords = {Neurology, Pediatrics}, pubstate = {published}, tppubtype = {article} } @book{2024, title = {Respiratory Medicine Made Simplified}, author = {Mohammed Raheem Hussain}, url = {https://www.akinik.com/products/3112/respiratory-medicine-made-simplified}, doi = {10.22271/ed.book.3112}, isbn = {9789361351266}, year = {2024}, date = {2024-11-25}, urldate = {2024-11-01}, booktitle = {Respiratory Medicine Made Simplified}, publisher = {AkiNik Publications}, address = {169, C-11, Sector-3, Rohini-110085, New Delhi, India.}, edition = {1st}, abstract = {Respiratory medicine plays a vital role in healthcare, addressing diseases that impact breathing and lung function. This simplified guide breaks down complex respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and respiratory infections. It covers essential aspects, including pathophysiology, diagnostic approaches, treatment strategies, and preventive measures. By simplifying medical concepts, this resource aims to enhance understanding for medical students, healthcare practitioners, and general readers interested in respiratory health and disease management.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @article{Acharya_2024, title = {Efficacy of early goal-directed therapy in septic shock management: a systematic review}, author = {Prakash Acharya and Shikha Virani and Sumayya Afreen and Arvin Perthiani and Elizabeth Sangster and Nidhi Lanka and Iana Malasevskaia}, url = {https://assets.cureus.com/uploads/review_article/pdf/291444/20241224-626697-7gbuve.pdf}, doi = {10.7759/cureus.74358}, issn = {2168-8184}, year = {2024}, date = {2024-11-24}, urldate = {2024-11-24}, journal = {Cureus}, volume = {16}, issue = {11}, pages = {e74358}, abstract = {Septic shock is a serious and life-threatening illness marked by potentially fatal and metabolic abnormalities, leading to high mortality rates in adult patients. Early goal-directed therapy (EGDT) was introduced as a systematic approach to manage septic shock through early, protocol-based hemodynamic optimization to improve outcomes. This systematic review aims to evaluate the efficacy of EGDT in managing adult patients with septic shock. A comprehensive search was conducted in multiple databases to identify relevant studies. Randomized controlled trials (RCTs), quasi-experimental, and observational studies with control groups were included. The quality of the studies was assessed using appropriate tools, and data was extracted for synthesis. This systemic review of 31 observational and RCT studies highlights the shortcomings of the one-size-fits-all EGDT strategy for septic shock. Although the preliminary research was encouraging, more recent studies have shown how important customized approaches are. Sophisticated monitoring methods such as tissue oxygenation and OER show potential in supporting customized hemodynamic therapy. Rigid protocols might not be the best option, but early intervention is essential. A move toward individualized treatment is necessary to enhance the prognosis of individuals suffering from septic shock. Future research should focus on well-designed RCTs, exploring comparative effectiveness, sustainability, and alternative monitoring techniques to refine the role of EGDT and develop more effective, evidence-based management strategies.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2024c, title = {Non-neoformans cryptococcal infections in the post-coronavirus disease-19 (COVID-19) era: are we ready to face the emerging challenge?}, author = {Umayra Fatima and Hina Ahmed and Gautam Singh and K. Y. Giri and Sania Azmi and Archana Meenakshi and Suresh Babu Jandrajupalli and Swarnalatha Chandolu and Abhishek Singh Nayyar}, url = {https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0044-1791998.pdf}, doi = {10.1055/s-0044-1791998}, issn = {2248-9614}, year = {2024}, date = {2024-11-04}, urldate = {2024-11-04}, journal = {Asian Journal of Neurosurgery}, volume = {20}, issue = {1}, pages = {190-195}, abstract = {Coronaviruses are a large group of viruses that infect animals as well as humans, while it is also suggested that, rarely, coronaviruses that infect animals can evolve and infect humans. Current evidence suggests that severe acute respiratory syndrome (SARS) coronavirus-2 leads to coronavirus disease-19 (COVID-19), the respiratory illness responsible for COVID-19 pandemic, while it has a zoonotic origin, closely related to the bat-origin SARS-like coronavirus. Also, as per the current knowledge, the disease may induce significant and persistent lymphopenia which in turn may increase the risk for various opportunistic infections. Cryptococcus laurentii is one such rare, but serious fungal infection which has been reported in post-COVID-19 disease and is a rising cause of concern since it can turn out to be fatal. The infection is caused by a non-neoformans rare human pathogen. The present case report describes the case of a 45-years old male patient who reported to the Outpatient Department (OPD) for a routine dental complaint with a grossly destructed tooth in left lower back tooth region due to extensive carious involvement, while, simultaneously, presenting with fever since 5 days in the post-COVID-19 phase, and was later diagnosed as being positive for C. laurentii infection on urine culture sensitivity test.}, keywords = {Dentistry}, pubstate = {published}, tppubtype = {article} } @article{Bushra_2024, title = {Molecular basis of sepsis: A new insight into the role of mitochondrial DNA as a damage-associated molecular pattern}, author = {Bushra and Shaik Iqbal Ahmed and Safia Begum and Maaria and Mohammed Safwaan Habeeb and Tahmeen Jameel and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S1567724924001259?via%3Dihub}, doi = {10.1016/j.mito.2024.101967}, issn = {1567-7249}, year = {2024}, date = {2024-11-01}, urldate = {2024-11-01}, journal = {Mitochondrion}, volume = {79}, issue = {suppl}, pages = {101967}, publisher = {Elsevier BV}, abstract = {Sepsis remains a critical challenge in the field of medicine, claiming countless lives each year. Despite significant advances in medical science, the molecular mechanisms underlying sepsis pathogenesis remain elusive. Understanding molecular sequelae is gaining deeper insights into the roles played by various damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) in disease pathogenesis. Among the known DAMPs, circulating cell-free mitochondrial DNA (mtDNA) garners increasing attention as a key player in the immune response during sepsis and other diseases. Mounting evidence highlights numerous connections between circulating cell-free mtDNA and inflammation, a pivotal state of sepsis, characterized by heightened inflammatory activity. In this review, we aim to provide an overview of the molecular basis of sepsis, particularly emphasizing the role of circulating cell-free mtDNA as a DAMP. We discuss the mechanisms of mtDNA release, its interaction with pattern recognition receptors (PRRs), and the subsequent immunological responses that contribute to sepsis progression. Furthermore, we discuss the forms of cell-free mtDNA; detection techniques of circulating cell-free mtDNA in various biological fluids; and the diagnostic, prognostic, and therapeutic implications offering insights into the potential for innovative interventions in sepsis management.}, keywords = {Biochemistry, Central Research Laboratory, General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Mohammed_2024, title = {Immune thrombocytopenic purpura (ITP) with ulcerative colitis (UC)}, author = {Sohaib K. Mohammed and Sanjana Budamagunta and Muneeb Khan and Steven Lippmann and Waleed Ahmed Khan}, url = {https://assets.cureus.com/uploads/case_report/pdf/130272/20241130-2602169-7p5bxq.pdf}, doi = {10.7759/cureus.72778}, isbn = {2168-8184}, year = {2024}, date = {2024-10-31}, urldate = {2024-10-31}, journal = {Cureus}, volume = {16}, issue = {10}, pages = {e72778}, abstract = {Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn’s disease. A relapsing, immune-modulated illness, it causes inflammation of the small and large intestines. UC is sometimes associated with extra-intestinal manifestations, including autoimmune cytopenias. Immune thrombocytopenic purpura (ITP) is a rare disorder which may induce an antibody-mediated, isolated reduction in platelet counts. ITP can present with extra-intestinal manifestations; the diagnosis follows the exclusion of other etiologies. Co-occurrences of ITP and UC in patients commonly are at the onset of UC or during illness recurrences. The severity of ITP correlates with the degree of UC pathology. We present a unique case of a 70-year-old presenting ulcerative colitis with immune thrombocytopenic purpura.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024e, title = {Awake bruxism in a patient with advanced alzheimer’s disease: an epiphenomenon of anxiety or marker of advanced disease}, author = {Sandhya Manorenj}, url = {https://journals.lww.com/neur/fulltext/2024/09000/awake_bruxism_in_a_patient_with_advanced.35.aspx}, doi = {10.4103/neurol-india.Neurol-India-D-23-00401}, issn = {0028-3886}, year = {2024}, date = {2024-10-31}, urldate = {2024-10-31}, journal = {Neurology India}, volume = {72}, number = {pmid39428794}, issue = {5}, pages = {1103-1104}, abstract = {NA}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Hemangiomas and vascular malformations}, author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood }, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/article/hemangiomas-and-vascular-malformations/MzAyNzk=/?is=1}, issn = {2277-8160}, year = {2024}, date = {2024-10-31}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {10}, pages = {85-86}, abstract = {Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specifc morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies. Vascular malformations and hemangiomas can cause significant morbidity and even mortality in both children and adults. For a number of reasons, physicians often confuse these lesions. The nomenclature for classifying these lesions is often used interchangeably and inappropriately. Clinically significant malformations are uncommon, and patients with these malformations are rarely encountered in primary medical facilities, rendering most physicians inexperienced in providing optimal care. Radiologists may become involved in the care of these patients when imaging or imaging-guided therapy is requested; therefore, knowledge of the imaging and treatment of these patients is essential. This article reviews the clinical and imaging approaches to vascular malformations and hemangiomas used in the multidisciplinary clinic, stressing a multidisciplinary approach, a practical categorization scheme, characteristic imaging findings, and commonly encountered clinical scenarios.}, keywords = {Physiology, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Cefoxitin and oxacillin resistance conundrums}, author = {Grishma Vijaykumar Kulkarni}, url = {https://journalsajrm.com/index.php/SAJRM/article/view/395}, doi = {10.9734/sajrm/2024/v18i11395}, issn = {2582-1989}, year = {2024}, date = {2024-10-29}, journal = {South Asian Journal of Research in Microbiology}, volume = {18}, issue = {11}, pages = {1-11}, abstract = {Recently, mecA negative Staphylococcus aureus strains with decreased susceptibility to oxacillin and cefoxitin have been sporadically reported worldwide. They are called as borderline oxacillin resistant Staphylococcus aureus (BORSA). Almost, more than 30% of such strains are often misinterpreted and reported as MRSA (methicillin resistant Staphylococcus aureus ) due to the hyperproduction of beta lactamase enzyme and other reasons which results in invitro reduced susceptibility to oxacillin as well as cefoxitin. Similar phenomenon is quite common in other staphylococci micrococci and macrococci. In order to identify beta lactamase hyperproducing staphylococci and other gram positive cocci and to avoid fals e reporting as methicillin resistant, a one year prospective study was conducted in Deccan college of medical sciences, Hyderabad, Telangana state, India in 2023. During one year duration, 5630 inpatient (IP) and 823 outpatient (OPD) samples accounting for total 6453 cultures were received in the microbiology laboratory. Out of this,100 cultures of different samples showing pure growth of gram positive cocci suggestive of staphylococci, micrococci and other Gram positive cocci were included in the present study and tested against different antibiotics panel as per CLSI guidelines (Clinical and Laboratory Standards Institute.) Inclusion of amoxiclav disc to the antibiotics test panel as per recommendation by the special phenotypic methods for the detection of antibacterial resistance in the manual of clinical microbiology was helpful to detect the beta lactamase hyperproducers (BHP) and helped to report correct identification of the organisms and curtailed the mismanagement of more than 95% of the patients. T herefore, I do recommend to differentiate borderline from true methicillin resistant strains to streamline the antibiotic therapy and hence further avoidance of selection of the resistant strains.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {A morphometry of jugular foramen in adult dry skulls}, author = {Hajira Fatima and Syeda Sadia Sameera and Surayya Tahseen and B. N. Shruthi and Pandit Vinodh Bandela}, url = {https://africanjournalofbiomedicalresearch.com/index.php/AJBR/article/view/3243}, doi = {10.53555/AJBR.v27i3S.3243}, issn = {1119-5096}, year = {2024}, date = {2024-10-28}, journal = {African Journal of Biomedical Research}, volume = {27}, issue = {S3}, pages = {4784-4788}, abstract = {Background: The jugular foramen is a bony canal in the posterior cranial fossa, located between the temporal and occipital bones at the posterior end of the petro-occipital fissure, above and lateral to the foramen magnum. The foramen divides into a large posterolateral compartment, the sigmoid part, which contains the sigmoid sinus accompanied by a meningeal branch of the occipital artery; and a small anteromedial compartment, the petrosal part, which contains the inferior petrosal sinus accompanied by a meningeal branch of the ascending pharyngeal artery. The glossopharyngeal, vagus, and accessory nerves course between the petrosal part and sigmoid part, lying medial to the intrajugular process. The jugular foramen has constantly fascinated ENT, radiologists, and neurosurgeons because of modern advances in surgical procedures involving skull base and middle ear. The present study was conducted to find morphological features and dimensions of jugular foramen. Materials and Methods: We have conducted present study with 102 dry adult skulls which were collected with medical students and departments. We recorded multiple parameters of jugular foramen with digital vernier callipers - Anteroposterior diameter, Mediolateral diameter, the fossa width and depth of fossa. All these measurement with help of vernier callipers. All the measurements were taken bilaterally and expressed in Mean+SD. Results :The jugular foramen depth was measured. Most of the foramina were having depth between 5 and 20 mm. We have also seen the dome of jugular fossa, in 38 skulls out of 102 skulls. We have observed the presence of a prominent superior jugular bulb was present bilaterally. Anterior to Posterior diameter-jugular foramen was 7.26+4.02mm, Medial to Lateral diameter-jugular foramen 16.02+4.26mm, Width-jugular fossa 9.02+3.12mm, Depth of jugular fossa 13.08+3.62mm. Conclusions: The present study concludes that the morphometric data and variations observed in the present study supports reported morphometric variations. Anatomical variations especially slit like jugular foramen and jugular fossa with high depth may be the reason for unusal clinical diagnosis.}, keywords = {Anatomy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Imtiyazuddin_2024, title = {The impact of cigarette smoking on glycemic control in patients with type 2 diabetes: a cross-sectional study}, author = {Mohammed Imtiyazuddin and Azeeza Tabassum and Arooba Fatima and Nabeela Tazeen and Rimsha Rimsha and Syeda Ayesha Siddiqua}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/file.php?val=the-impact-of-cigarette-smoking-on-glycemic-control-in-patients-with-type-2-diabetes-a-crosssectional-study_October_2024_5257591979_8407038.pdf}, doi = {10.36106/gjra/8407038}, issn = {2277-8160}, year = {2024}, date = {2024-10-15}, urldate = {2024-10-15}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {10}, pages = {112-114}, abstract = {Background: Cigarette smoking is a well-known risk factor for various cardiovascular and metabolic diseases, including diabetes. Its potential impact on glycemic control, particularly in type 2 diabetic patients, warrants further investigation, as poor glycemic control is associated with increased complications and morbidity in this population. Aim: This study aims to evaluate the effect of cigarette smoking on glycemic control in type 2 diabetic patients, comparing smoking and non-smoking groups to identify key risk factors that inuence glycemic outcomes. Materials & Methods: A cross-sectional, comparative study was conducted with 60 participants, 30 with type 2 diabetes and 30 non-diabetic controls. Demographic, clinical, and lifestyle variables, including age, gender, BMI, blood pressure, hypertension status, and cigarette smoking, were collected. Univariate and multivariate analyses were used to assess the association between these variables and glycemic control, focusing on smoking as a potential risk factor. Results: Cigarette smoking was signicantly associated with poor glycemic control in type 2 diabetic patients, with an adjusted odds ratio (OR) of 3.57 (95% CI: 1.71–7.58, p = 0.001). Age (adjusted OR: 1.07, 95% CI: 1.05–1.10, p = 0.001) and systolic blood pressure (adjusted OR: 1.03, 95% CI: 0.99–1.04, p = 0.001) were also signicant risk factors. Gender, BMI, and diastolic blood pressure did not show signicant associations with glycemic control. Conclusion: Cigarette smoking, along with age and systolic blood pressure, is a key determinant of poor glycemic control in type 2 diabetic patients. These ndings underscore the importance of smoking cessation and comprehensive management of modiable risk factors to improve glycemic outcomes in this population.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Shareef_2024, title = {The impact of the COVID-19 pandemic on the quality of life of MBBS students at Deccan College of Medical Sciences, Hyderabad, Telangana}, author = {Fateen Shareef and Abdul Wasay Mohammed and Azha Fatima and Abdul Basith and Azeeza Tabassum}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/file.php?val=the-impact-of-the-covid19-pandemic-on-the-quality-of-life-of-mbbs-students-at-deccan-college-of-medical-sciences-hyderabad-telangana_October_2024_2559791759_9207174.pdf}, doi = {10.36106/gjra/9207174}, issn = {2277-8160}, year = {2024}, date = {2024-10-15}, urldate = {2024-10-15}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {10}, pages = {115-117}, abstract = {Background: COVID-19 has been recognized as an additional stressor for the general populace, particularly for medical students. It has been established that medical students exhibit elevated levels of psychological distress manifested through symptoms of depression, anxiety, and stress. This research aims to evaluate the repercussions of the COVID-19 pandemic on the quality of life of MBBS students, with a specic focus on their experiences with E-learning. Aim: The primary aim of this study was to examine the impact of the COVID-19 pandemic on the overall quality of life of MBBS students, with a particular focus on their e-learning experiences. Methods: This is a cross-sectional survey, executed with a sample size of 120 MBBS students amidst the second wave of the pandemic, at Deccan College of Medical Sciences. The survey employed a questionnaire disseminated online (Google Forms) to the cohort of medical students. The data were subjected to statistical analysis utilizing SPSS software. Results: The study involved 120 participants, with a higher proportion of females (57.5%) than males (42.5%). The majority were aged 20 years (38.3%) and in their 1st or 2nd year of MBBS (39.2% and 42.5%, respectively). Most participants rated their quality of life as good (70.8%) during the COVID-19 pandemic, although 15.8% reported poor sleep quality. Regarding academic performance, 55.8% felt their study quality was good, but 40.8% disagreed that e-learning was sufcient for their education. Mobile phones were the most commonly used device for elearning (40%). Conclusions: The students identied a substantial interruption to their medical education, expressed an aspiration to persist with in-person clinical rotations, and demonstrated a readiness to embrace the risk of contracting COVID19. They perceive a heightened sense of safety following their vaccination. Our innovative ndings furnish a robust basis to inform the delineation of medical student responsibilities within the clinical setting amidst the ongoing pandemic and potential future health crises.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ansari_2024, title = {Granulomatosis with polyangiitis mimicking infective endocarditis: a case report}, author = {Yusra Ansari and Saad Ali Ansari and Fawaz Mohammed and Zaina Ali Khan and Zunaira Ansari and Dylan Sanford and Tahir Muhammad Abdullah Khan}, url = {https://assets.cureus.com/uploads/case_report/pdf/299437/20241103-789101-iyb2m8.pdf}, doi = {10.7759/cureus.70844}, issn = {2168-8184}, year = {2024}, date = {2024-10-04}, urldate = {2024-10-04}, journal = {Cureus}, volume = {16}, issue = {10}, pages = {e70844}, abstract = {Granulomatosis with polyangiitis is a rare systemic disease that causes necrotizing granulomatous inflammation of small- and medium-sized blood vessels. We present the case of a 46-year-old male with medical history significant for chronic sinusitis, prior history of drug abuse, and a recent tooth infection. He was suspected to have infective endocarditis, but further workup revealed diagnostic findings of granulomatosis with polyangiitis. We discuss how the signs and symptoms of granulomatosis with polyangiitis can overlap with infective endocarditis, a pathophysiologically distinct condition with a strikingly similar presentation.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Pathan_2024, title = {Prevalence of attention deficit hyperactivity disorder among primary school children in Hyderabad, South India}, author = {Habib Khan Gulab Khan Pathan and Shalini Akunuri and Shabahat Tayyab and Zafar Sultana Abdul Saleem}, url = {https://annchildneurol.org/upload/pdf/acn-2024-00570.pdf}, doi = {10.26815/acn.2024.00570}, issn = {2635-909X}, year = {2024}, date = {2024-10-01}, urldate = {2024-10-01}, journal = {Annals of Child Neurology}, volume = {32}, issue = {4}, pages = {226-231}, abstract = {Purpose: Attention deficit hyperactivity disorder (ADHD) is among the most prevalent neurodevelopmental disorders in childhood, and its incidence has increased in recent years. However, the frequency of ADHD varies significantly across different countries and regions. This study aimed to determine the prevalence of ADHD among primary school children in Hyderabad, India, as well as to raise awareness about ADHD among teachers.Methods: This descriptive cross-sectional study included 700 school-aged children between 5 and 12 years old, selected according to specific inclusion and exclusion criteria. The teachers' version of the Vanderbilt Assessment Scale, a rating scale grounded in Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria, was employed to diagnose ADHD. Results: The prevalence of ADHD in this study was 9.57% (67 out of 700), with a mean age of 8.9 years. ADHD was more prevalent in boys than in girls, with a sex ratio of 3:1. The combined type of ADHD was the most common (52.3%), followed by the attention deficit type (29.8%) and the hyperactive-impulsive type (17.9%). Conclusion: The prevalence of ADHD among schoolchildren in middle-income countries, such as India, is sufficiently high to impose a significant societal burden. Therefore, it is imperative that all elementary school teachers receive training on how to screen for indicators of ADHD.}, keywords = {Anatomy, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ali_2024b, title = {Effectiveness, utility, and economic analysis of three-drug treatment vs two-drug treatment in chronic obstructive pulmonary disease patients}, author = {Syed Aamir Ali and Subhranshu Panda and M. Aleemuddin Naveed}, url = {https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1126}, doi = {10.5005/jp-journals-11010-1126}, issn = {2277-9019}, year = {2024}, date = {2024-09-30}, urldate = {2024-09-30}, journal = {Indian Journal of Respiratory Care}, volume = {13}, issue = {3}, pages = {146-151}, abstract = {Aim and background: Inhaled corticosteroids (ICS) and bronchodilators remain the mainstay of therapeutic modalities available for the management of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the effectiveness, utility, and economic analysis of a three-drug treatment vs a two-drug treatment in COPD patients. Materials and methods: An observation was conducted at a superspecialty hospital in Hyderabad. Out of the 115 patients recruited from the inpatient and outpatient wards of the Pulmonology Department, 55 patients received triple therapy containing ICS, long-acting β-agonists (LABA), and long-acting muscarinic antagonists (LAMA), whereas 60 patients were treated with dual therapy comprising ICS/LABA. Cost-effectiveness was assessed based on forced expiratory volume in 1 second (FEV1) (FEV1% predicted), St George's respiratory questionnaire (SGRQ) scores, SGRQ responder ratio, COPD assessment test (CAT) scores, and incremental cost-effectiveness ratio (ICER). Results: Results signified the enhanced potency of three-drug treatment vs two-drug treatment as proven by the improvement in average difference from initial values in (1) FEV1% predicted value of 4.36 [95% confidence interval (CI) (2.9–5.82)], (2) SGRQ scores of −6.76 [95% CI (−2.14 to −11.38)], SGRQ responder ratio of 13.25 (3.72–47.24), CAT scores of −5.15 [95% CI (−9.87 to −0.43)] and ICER of 3522 [95% CI (14682 to −7638)]. Conclusion: Triple therapy comprising LABA, LAMA, and ICS can optimize lung function and improve clinical outcomes, leading to overall enhancement of well-being compared to LABA/ICS dual therapy in moderate to severe COPD patients. Clinical significance: Three-drug treatment comprising ICS/LABA/LAMA is an effective and cost-effective therapeutic approach for managing moderate and severe COPD compared to ICS/LABA dual therapy. This is evidenced by improvements in spirometry values (FEV1% predicted) and health-related quality of life (HRQoL).}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Basith_2024, title = {Efficacy of Tru-cut biopsy of the cervical lymphnodes over FNAC for detecting MTB using CBNAAT histopathology and cultures}, author = {Mohammed Abdul Basith and M. Aleemuddin Naveed and Ashfaq Hasan and Fahad Abdullah Bin Breik and Syed Mahmood Ahmed and Shireen Adeeb Mujtaba Ali}, url = {https://journals.lww.com/jdyu/fulltext/2024/13030/efficacy_of_tru_cut_biopsy_of_the_cervical.11.aspx}, doi = {10.4103/jdrysruhs.jdrysruhs_32_24}, issn = {2950-5356}, year = {2024}, date = {2024-09-27}, urldate = {2024-07-01}, journal = {Journal of Dr. YSR University of Health Sciences}, volume = {13}, issue = {3}, pages = {247–252}, publisher = {Wolters Kluwer - Medknow}, abstract = {Introduction: The present study was carried out to see the usefulness of Tru-cut biopsy over fine needle aspiration (FNA) in diagnoses of tuberculosis (TB) cervical lymphadenopathy and comparing their yields by performing ZN staining, culture, cytology, histopathology, and CBNAAT. Observation and Results: It was found that the yield of Tru cut was significantly more in ZN staining and histopathology. Even though the yield was more in culture and CBNAAT also, it was not statistically significant. FNA is a popular method which is very widely used, but it has a low yield. From the results, it was inferred that for FNA, the positive rate was 27.6%, 38.4%, 67.7%, and 43% for the four modalities of ZN staining, CBNAAT, cytology, and acid-fast bacilli cultures, respectively. Comparatively, for Tru-cut biopsy, the positive rate was 36.9%, 46.2%, 92.3%, and 47.7%, respectively, in all four modalities. It was noticed that the highest value was recorded for histopathology, followed by culture and CBNAAT for Tru-cut biopsy procedures. Comparatively, FNA showed the highest negative rate for ZN staining and CBNAAT. Conclusion: The present study also highlights the importance of Tru-cut biopsy over FNA. It is one of the emerging techniques which if used properly could offer a better yield. Further results and conclusions are discussed in the paper.}, keywords = {Central Research Laboratory, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024f, title = {Unilateral asymptomatic multiple cerebral microbleeds: a very rare radiological entity}, author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka and Sravan Kumar Marupaka}, url = {https://journals.lww.com/annalsofian/fulltext/2024/27050/unilateral_asymptomatic_multiple_cerebral.18.aspx}, doi = {10.4103/aian.aian_383_24}, issn = {0972-2327}, year = {2024}, date = {2024-09-06}, urldate = {2024-09-06}, journal = {Annals of Indian Academy of Neurology}, volume = {27}, number = {pmid39240195}, issue = {5}, pages = {573-575}, abstract = {NA}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024d, title = {Basal cistern sparing pattern of subarachnoid hemorrhage: an imaging clue for SAH beyond aneurysm}, author = {Sandhya Manorenj}, url = {https://journals.lww.com/neur/fulltext/2024/07000/basal_cistern_sparing_pattern_of_subarachnoid.40.aspx}, doi = {10.4103/neurol-india.Neurol-India-D-23-00705}, issn = {0028-3886}, year = {2024}, date = {2024-08-31}, urldate = {2024-08-31}, journal = {Neurology India}, volume = {72}, number = {pmid39216057}, issue = {4}, pages = {892-893}, abstract = {NA}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Hussaini_2024b, title = {A systematic review of isotretinoin and its contraindications in peanut, soybean and cashew nut allergies}, author = {Naayema Hussaini and Nabihah Hussaini and Jousef Bakir and Rabeea Mirza and Rubina Fatima}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/jvc2.536}, doi = {10.1002/jvc2.536}, issn = {2768-6566}, year = {2024}, date = {2024-08-21}, urldate = {2024-08-21}, journal = {JEADV Clinical Practice}, volume = {4}, issue = {1}, pages = {42-48}, abstract = {Should oral isotretinoin be considered contraindicated in patients with peanut, soybean, and cashew allergies? A systematic literature search of PubMed, EMBASE and The Cochrane Library up to July 2023 was conducted to identify randomised control trials (RCTs), cohort studies, case reports, and cross‐sectional studies investigating if isotretinoin should be contraindicated in patients with various allergies including peanut, soybean, and cashew allergies. Primary outcomes explored included relapse, adverse effects, and safety profiles of oral isotretinoin at varying doses. Secondary outcomes included efficacy as well as economic considerations. The quality of studies, including risk of bias, was assessed using GRADE (Grading of Recommendations, Assessment, Development and Evaluations). A total of eight studies were included. The majority of studies suggested that isotretinoin should not be considered inadvisable. In cases with peanut allergies, minimal adverse effects were noted with various dosages of isotretinoin and prolonged treatment duration. In cases with soybean allergies, similar results and conclusions were obtained to the cases with peanut allergies, however the number of studies were not of similar value to those of peanut allergies. Comparison between studies was challenging due to differing methods of assessment, subjective interpretation of severity and duration of follow‐up. This review highlights the need for an adequately powered RCT, to decipher whether isotretinoin should not be given to patients with peanut, soybean or cashew allergies.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Alam_2024, title = {Correlation between ferritin levels and mortality rate in stroke patients in a tertiary care hospital}, author = {Shameema Alam and Rimsha Rimsha and Fnu Rukhayya and Syed Asim Ali and Syeda Kulsoom Quadri and Syeda Ayesha Siddiqua}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/file.php?val=correlation-between-ferritin-levels-and-mortality-rate-in-stroke-patients-in-a-tertiary-care-hospital_August_2024_2441001807_3410083.pdf}, doi = {10.36106/gjra/3410083}, issn = {2277-8160}, year = {2024}, date = {2024-08-15}, urldate = {2024-08-15}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {8}, pages = {153-154}, abstract = {Objective: This research study examines the possibility of serum ferritin levels as a predictive factor in cases of acute ischemic stroke. Methods: This study was a cross-sectional analysis that involved 45 patients who were registered in the General Medicine Department of an outpatient facility located in a Tertiary Care Hospital in Telangana. All individuals with a newly developed focal neurological disability caused by a stroke were included in the research. The research included a total of 45 patients, with 15 individuals in each group categorized as mild, moderate, or severe. The study evaluates the association between serum ferritin levels and other clinical characteristics, such as stroke severity and consciousness state. Results: The severe group had the highest mean blood ferritin level, measuring 411.4 with a standard deviation (SD) 55.4. An evident correlation was found between ferritin levels and the occurrence of unconsciousness. A statistically signicant correlation was found between high levels of ferritin in the blood and severe stroke. Conclusions: Study ndings indicate that serum ferritin may be a valuable prognostic indicator in cases of acute ischemic stroke, assisting in the categorization of patient risk and enhancing clinical decision-making.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohammed_2024b, title = {A questionnaire-based study on knowledge, attitude and practice of interns and postgraduates about adverse drug reactions reporting in a tertiary care hospital, Telangana}, author = {Abdul Wasay Mohammed and Fateen Shareef and Azeeza Tabassum and Azha Fatima and Abdul Basith}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/file.php?val=a-questionnairebased-study-on-knowledge-attitude-and-practice-of-interns-and-postgraduates-about-adverse-drug-reactions-reporting-in-a-tertiary-care-hospital-telangana_August_2024_1417080224_0111552.pdf}, doi = {10.36106/gjra/0111552}, issn = {2277-8160}, year = {2024}, date = {2024-08-15}, urldate = {2024-08-15}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {8}, pages = {193-196}, abstract = {Background: Adverse drug reactions (ADRs) must be reported by medical professionals to prevent drugrelated tragedies. The pervasive underreporting of ADRs is problematic. Increased awareness helps identify and prevent ADRs. It's crucial to educate young healthcare workers on ADR reporting in clinical practice. Our study aims to analyze interns' and postgraduates' ADR reporting knowledge, attitude, and practice. Methods: This research, was carried out on medical interns and postgraduates at a tertiary care hospital in Telangana. It is a questionnaire-based study of 110 medical students. The study participants were given a series of standard questions on knowledge, attitude, and practice on ADR reporting. Before the study ethical letter was acquired. SPSS software was used to evaluate the collected data, and a p value of < 0.001* was considered signicant. Results: Out of 110 study participants, most participants were from the 21-30 years of age group (48.3%) with a male predominance (67.3%). Interns (65.5%) were in the majority than the postgraduates (34.5%) The study indicated that the overall knowledge ( 2 =55.296, p = 0.001*), attitude (2 =64.873, p= 0.001*), and practice (2=88.148, p= 0.001*) of study participants were statistically signicant. Conclusions: Interns and postgraduates are aware of ADR reporting, but interns lack practice and postgraduates lack attitude. Most participants felt reporting adverse drug responses was their top responsibility, along with patient safety. Education and sensitization of prospective medical professionals on ADR reporting can improve patient compliance and prevent tragedies.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Sameera_2024, title = {Study of correlation of morphometric and radiological parameters of hyoid bone In the population of Telangana}, author = {Syeda Sadia Sameera and Hajira Fatima and Zafar Sultana Abdul Saleem and Shaik Hussain Saheb}, url = {https://www.afjbs.com/uploads/paper/ab628f2e1eafc839b644aa846cf907a4.pdf}, doi = {10.48047/AFJBS.6.Si4.2024.6127-6133}, issn = {2663-2187}, year = {2024}, date = {2024-08-15}, urldate = {2024-08-15}, journal = {African Journal of Biological Sciences}, volume = {6}, issue = {Si4}, pages = {6127-6133}, abstract = {Background: The hyoid bone in humans is anatomically positioned in the anterior, upper aspect of the neck and is typically horseshoe-shaped. This bone plays a vital role in forensic studies as an indicator for diagnosing asphyxia deaths due to hanging and strangulation. Since modern facilities have improved the accuracy of measurement and study, present work correlates the morphometric features from the dry cadaveric specimens, as well as scanned images from living hyoid. This will generate useful data for medicolegal and anthropometric uses. This study conducted to corelate the morphometric and radiological parameters of adult hyoid bone in the population of Telangana. Material and Methods: We conducted this study with 40 dried specimens of hyoid bones. We have measured the parameters using vernier caliper and correlated in living using CT scan. In present study we have recorded the parameters like, Length of right greater cornu, Length of left greater cornu, Anteroposterior distance at the middle of body of hyoid bone, Length of Hyoid bone. Results: All the morphometric parameters of hyoid bone corelate with the radiological parameters. There is no significant difference between the dry bone and CT scan measurements in case of length of body of hyoid bone where as there is significant difference between the other three parameters. Conclusion: The findings of this study may be helpful for anthropometry and medicolegal importance and the surgeries in this reason. }, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Ashraf_2024, title = {Study of testosterone levels in type II diabetes mellitus male patients in Telangana population}, author = {Syed Mustafa Ashraf and Syeda Asma Gulnaaz}, url = {https://academicmed.org/Uploads/Volume6Issue4/83.%20[3614.%20JAMP_Dr%20Makandar%20U.K]%20415-417.pdf}, doi = {10.47009/jamp.2024.6.4.83 }, issn = {2687-5365}, year = {2024}, date = {2024-07-26}, urldate = {2024-07-26}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {6}, issue = {4}, pages = {405-407}, abstract = {Background: Type-II DM is a major health problem globally; it affects mainly the cardio-vascular system, including the lipid profile, and also impairs hormone pathways like insulin and sex hormones in males, leading to impotency. Materials and Methods: 195 (one hundred ninety-five) type II DMs of different age groups were studied and compared with 190 normal (controlled) groups. The blood investigation included FBS and PP. Blood urea, serum creatinine, Hbs.A1C, lipid profile, urine albumin, creatinine ratio, and serum testosterone were estimated by chemiluminescence immune assay and HbA1c by HPLC. Results: The BMI, age, HBSA1C, and serum testosterone level were compared with the control group, and the p value was highly insignificant (p<0.001). Conclusion: It is confirmed that type II DM patients have lower serum testosterone levels. Diabetes mellitus affects the vascularity of vital organs and impairs the normal functions of tests, leading to male sterility. The present study helps physicians or endocrinologists treat such patients efficiently.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Yeshwanth_2024, title = {Mitochondrial potential and Nd1 gene expression analysis in platelets for quality assessment}, author = {Asapanna Naga Sai Venkata Yeshwanth and Sara Jabeen and Aleem Ahmed Khan and Nusrath Fathima}, url = {https://www.scholasticopenaccess.org/SCMS/SCMS-02-0043.pdf}, year = {2024}, date = {2024-07-16}, urldate = {2024-07-16}, journal = {Scholastic Medical Sciences}, volume = {2}, issue = {5}, pages = {1-4}, abstract = {Background: Platelets are the tiniest blood particles, and their shape shows how lively they are. They are largely concerned with hemostasis, or the process of starting blood coagulation. The diverceful activity of platelet and molecules released from platelet storage granules are both necessary for these various activities. Initiating homeostasis, an inflammatory response, and an immune response at the site of injury during the acute phase of wound healing, as well as encouraging angiogenesis and tissue regeneration during the repair phase, is examples of how these platelet activities interact synergistically. Therefore mitochondria function/quality plays various important roles in several disease processes. Several studies have demonstrated mitochondria dysfunction in various chronic degenerative diseases (ex: cardiovascular diseases; Type 2 diabetes). Hence, there is need for quality assessment platelet mitochondrial DNA for platelet functions. Materials and Methods: Platelets were incubated with Rhodamine 123 exclusive dye to assess the membrane potential. The cytotoxicity of platelets were assed at different dilution point using MTT assay. The activity of platelet mitochondrial (mtDNA) was assessed using ND1 gene. Results: The aggregation of platelets with Rhodamine dye indicates the active state of platelets. The decline of platelets with high concentration MTT assay was observed. The activity of mtDNA in platelets the ND1 gene and internal control 12s gene were expressed at same indicating the active presence of mtDNA in platelets. Conclusion: The Rhodamine 123 stain with platelet indicates that the presence of mitochondrial membrane potential. The ND1 gene expression indicates the quality of mitochondrial DNA in platelets.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Afreen_2024, title = {A cross-sectional study on undernutrition among under-5 children living in the rural area of Hyderabad}, author = {Afreen and Sultan Rizwan Ahmad and Madhipati Sai Krishna}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/12571/7621}, doi = {10.18203/2394-6040.ijcmph20241824}, issn = {2394-6032}, year = {2024}, date = {2024-06-28}, urldate = {2024-06-28}, journal = {International Journal of Community Medicine and Public Health}, volume = {11}, issue = {7}, pages = {2686–2690}, abstract = {Background: Undernutrition is a silent emergency and one of the most common causes of morbidity and mortality among under-5 children throughout the world. A serious public health concern and can have significant effect on child’s overall growth and development. The prevalence of undernutrition is two folds higher among rural area compared with urban area, therefore present study aims to study the prevalence of undernutrition and associated factors among under-5 children living in rural area of Hyderabad. Methods: A community based cross-sectional study was conducted between April 2023 to June 2023 in rural field practice area of a medical college in Hyderabad. A total of 364 under-5 children residing in study area were selected by simple random technique. Data about socio-demographic variables were collected by questionnaire and anthropometrics were measured using standard techniques. Results: In the present study, about 33% of under-5 children are underweight and 35% are stunted. The under-5 children belonged to lower socioeconomic class were significantly more likely to be underweight (40%) and stunted (42%). Family size >6 members were significantly underweight (48%) as well as stunted (47%). Children with low birth weight i.e. <2.5 kg had significantly higher rates of underweight (43%) as well as stunting (45%). Among the children with weaning age less than 6 months, 47% were underweight and 45.6% were stunted. Conclusions: Socio economic status, family size, birth weight, and weaning age are important determinants of undernutrition.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Vuppala_2024, title = {Clinico-demographic profile and outcome of acute pediatric hydrocarbon poisoning in South India}, author = {Anil Kumar Vuppala and Rama Krishna Nelakurthi and Shalini Akunuri and Ahlaam Arif and M. Aleemuddin Naveed}, url = {https://www.publichealthtoxicology.com/pdf-189940-111867?filename=Clinico_demographic.pdf}, doi = {10.18332/pht/189940}, issn = {2732-8929}, year = {2024}, date = {2024-06-28}, urldate = {2024-06-28}, journal = {Public Health Toxicology}, volume = {4}, issue = {2}, pages = {1-6}, abstract = {Introduction: Acute hydrocarbon poisoning in children is an important cause of morbidity and mortality in developing countries. This study aimed to understand clinico-demographic profile and outcome of acute hydrocarbon poisoning in children belonging to low-middle economy families from South India. Methods: A prospective observational study was conducted over 18 months from January 2022 to June 2023 in a private medical college from South India for children between 1 month and 18 years of age admitted with a history of acute hydrocarbon poisoning. Results: Out of 1568 admissions, 29 children had acute hydrocarbon poisoning. Median age was 2.6 years (range: 6 months-15year). The majority (58.6%) belonged to toddler age group. The male-to-female ratio was 1.6:1. Most (48.3%) cases were seen during summer. All poisonings were accidental and occurred via the ingestion route. Paint thinner (75.9%) and mosquito repellent (20.7%) were the most common agents implicated. Vomiting (69%), cough (24.1%), and respiratory distress (20.7%) were the predominant symptoms noted. Chest radiograph was abnormal in 10% of patients. Respiratory support was provided in 44% of patients. 70% of patients were discharged within 24 hours. There was no mortality. Conclusions: Acute hydrocarbon poisoning is a preventable cause of mortality and morbidity in children. The majority of cases occur in the toddler age group and are accidental. Most patients improve with simple conservative measures. Following unit protocols for the management avoids unnecessary investigations, and medications and promotes early discharge.}, keywords = {Emergency Medicine, Pediatrics, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Gulnaaz_2024, title = {Comparative study of antioxidant vitamins and enzymes in alcoholic liver diseases in Telangana population}, author = {Syeda Asma Gulnaaz and Syed Mustafa Ashraf}, url = {https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article133.pdf}, doi = {10.5281/zenodo}, issn = {0975-1556}, year = {2024}, date = {2024-06-26}, urldate = {2024-06-26}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {16}, issue = {7}, pages = {811-814}, abstract = {Background: The liver is the largest site of metabolism in the body. It also provides the primary site for alcohol metabolism. It leads to oxidative damage due to alcohol, which causes a decrease in anti-oxidant enzymes and chemicals. Method: 60 alcoholic liver disease patients were compared with the same number of healthy (controlled) groups. Clinical and laboratory investigations were carried out using venous blood plasma vit. E levels by Baker Hatal method, ascorbic acid by the Teitz method, and SVD by the Beers-Seizer method. Results: The comparison of non-enzymatic oxidant parameters. Ascorbic acid, vitamin E, and the comparison of anti-oxidant enzymes SOD, GPX in both groups were statistically highly significant (p<0.00). Conclusion: The present study indicates that alcohol promotes oxidative stress, a major cause of alcohol toxicity in liver Vitamin E is a potential therapeutic agent for alcohol-induced oxidative damage in liver.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Sarwath_2025, title = {Navigating mortality and morbidity trends in geriatric patients post-surgical fixation of hip surgery}, author = {Sadia Sarwath and Fouzia Nikhath and Mohammed Siddique Mohiuddin and Adeeba Sana}, url = {https://www.sciencedirect.com/science/article/pii/S2773157X24001243}, doi = {https://doi.org/10.1016/j.jorep.2024.100429}, issn = {2773-157X}, year = {2024}, date = {2024-06-24}, urldate = {2024-06-24}, journal = {Journal of Orthopaedic Reports}, volume = {4}, issue = {3}, pages = {100429}, abstract = {Introduction: Hip fractures in the elderly pose significant risks, with potentially life-threatening complications. This retrospective analysis examines post-surgery mortality factors, focusing on age, pre-existing medical conditions, and surgical delay, while considering demographic variables and comorbidities. Methods: Data from patients undergoing post-hip immobilization surgery were retrospectively collected from hospital records. A follow-up questionnaire was administered approximately one year post-surgery via telephone. Results: Among 52 patients with hip fractures, 23 were women and 29 were men. The study's mortality rate stood at 30.7 %. Analysis of chi-square statistics for males (1.3535) and females (0.244669) showed no sex-related mortality impact. However, a significant p-value from the t-test indicated better post-surgery daily activity performance in males than females. Conclusion: The intervention, timely surgery and educating elderly patients on surgery delay risks could substantially mitigate mortality rates. Incorporating these strategies into clinical practice may yield considerable benefits in hip fracture management. Thus, the outcome of this is reduced mortality rates and improved postoperative functional outcomes.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Naaz_2024, title = {Epidermoid cyst in uterine cervix–a rare and unusual location}, author = {Farha Naaz and Asfiya Fatima and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/epidermoid-cyst-in-uterine-cervix-a-rare-and-unusual-location_May_2024_1521776051_9602538.pdf}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2024}, date = {2024-05-31}, urldate = {2024-05-31}, journal = {Indian Journal of Applied Research}, volume = {15}, issue = {5}, pages = {61-62}, abstract = {Cervical epidermoid cysts and uncommon benign cystic lesions were identied in a 50-year-old woman. The patient presented with heavy menstrual bleeding and lower abdominal pain, and after initial treatment with endometrial biopsy and hemostatic uterine curettage, a total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The gross examination of the specimen revealed a hypertrophied cervix with a cyst lled with grey-white substance, as well as a polypoidal mass in the fundus and intramural broids. Histopathological examination conrmed the diagnosis of a cervical epidermoid cyst as an incidental nding. Squamous metaplasia was conned to the cervical mucosa. The precise etiology remains unclear, but post-parturient implantation of vestigial embryonic tissue might be a contributing factor as there is no other associated etiology in this case. This case report emphasizes the importance of considering epidermoid cysts in the differential diagnosis of cervical masses and highlights the need for further research to better understand the formation and management of these rare cysts.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2024, title = {Ovarian hydatid cyst-a rare entity: a case report}, author = {Hafeza Syeda Farha Sultana and Samia Mohammed and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/ovarian-hydatid-cyst-a-rare-entity-a-case-report_May_2024_7615171205_7202728.pdf}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2024}, date = {2024-05-31}, urldate = {2024-05-31}, journal = {Indian Journal of Applied Research}, volume = {14}, issue = {5}, pages = {66-67}, abstract = {Hydatid disease is a zoonosis caused by the transmission of the larval stage of Echinococcus granulosus (dog tapeworm) either by consuming contaminated food and water or due to hand to mouth transmission from infested animals or partially cooked meat. Humans are the accidental host. Hydatid cyst of ovary is an extremely rare presentation accounting for 0.2-1% of all cases. A 47-year-old woman presented to the surgery department of Owaisi Group of Hospitals (PEH) with a chief complaint of abdominal pain for 1 week. USG examination revealed bilateral simple ovarian cysts and CT scan Fndings showed bilateral complex ovarian cysts. Routine investigations were normal. Surgery was performed for suspected ovarian cyst. The cysts were extracted and sent for HPE which confrmed the diagnosis of hydatid ovarian cyst. The incidence of hydatid cyst in the female reproductive system is less than 0.5% of all cases. The clinician must have a high index of suspicion whenever cystic lesions of pelvis are found as any spillage while operating may lead to anaphylactic shock and recurrence. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Kareem_2024, title = {A case report on pituitary neuroendocrine tumor (PNET) with oncocytic change}, author = {Sana Munazza Kareem and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/a-case-report-on-pituitary-neuroendocrine-tumor-pitnet-with-oncocytic-change_May_2024_5817170215_4803207.pdf}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2024}, date = {2024-05-31}, urldate = {2024-05-31}, journal = {Indian Journal of Applied Research}, volume = {14}, issue = {5}, pages = {83-84}, abstract = {Neuroendocrine tumors (NET) originate from the diffuse neuroendocrine system. These can arise in almost every organ of the body, although they are most commonly found in the gastrointestinal tract and respiratory system. The skull base and sellar region are extremely rare sites for neuroendocrine carcinoma. Intracranial originating is lower than 0.74 %. A 55year old male was admitted in the neurosurgery department of Owaisi Group of Hospitals (PEH) with chief complaint of severe headache for 15 days, associated with giddiness, nausea and left eye vision disturbance. MRI showed Pituitary macroadenoma. Surgery was performed and the excised specimen of Pituitary adenoma was sent for HPE which revealed that the lesion was a Neuroendocrine tumor. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Severe cigarette smoking caused prostate cancer and bony metastasis - a case study}, author = {Humera Ayesha and Syed Abbas Mujtaba}, url = {https://rjpn.org/ijcspub/viewpaperforall.php?paper=IJCSP24B1253}, issn = {2250-1770}, year = {2024}, date = {2024-05-31}, journal = {International Journal of Current Science}, volume = {14}, issue = {2}, pages = {223-226}, abstract = {Severe cigarette smoking is considered to be one of the largest addictions and has been a major health problem. Around 8 million people die due to smoking9. Estimated that 1 in 4 adult men in the world smoke tobacco which has carcinogenic agents like Polycyclic aromatic hydrocarbons (PAH)3 causing gene mutations4 such as PTEN5, PREX2, AGO2 which weakens immune system, DNA damage finally resulting in cellular proliferation and developing cancer. Along the side of lung cancer in smokers we observed that prostate11 cancer is also being diagnosed in the worldwide population among men, early deaths occurred due to bony metastasis2 for not quitting smoking. The associated gene mutation between smoking and prostate cancer can be PTEN through AKT activation pathway. severe cigarette smoking also contributes to heart disease and various other cancers like throat and gastric etc.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {A comparative study of either sex on visual reaction time}, author = {Humera Ayesha and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/a-comparative-study-of-either-sex-on-visiual-reaction-time/Mzk1NTA=/?is=1&b1=&k=}, issn = {2249-555X}, year = {2024}, date = {2024-05-31}, journal = {Indian Journal of Applied Research}, volume = {14}, issue = {5}, pages = {1-2}, abstract = {Human reaction time denotes time taken by an individual to react to an external stimulus. The response obtained while measuring human reaction time is voluntary response obtained after training and is specific in nature. The purpose of this study was to find out whether the reaction time was faster for green light stimuli or red-light stimuli. And to compare the visual human reaction times in males and females. Reaction is a purposeful voluntary response to stimulus. The time interval between presentation of stimulus and getting a appropriate voluntary motor response is a reaction time1.it measures for alertness and processing speed of CNS which gets influenced with age, gender, physical activity and IQ of a subject. Different studies were conducted worldwide among different individuals have reported the prevalence of stress ranging from 27% to 73%. Different stress acts as an acute stressor which affects cognitive functions. It is found that the stress elicits elevated activity in the hypothalamic-pituitary-adrenal axis and increased release of cortisol. The study was planned to investigate gender difference. Choice reaction time (CRT) was used to evaluate the cognitive performance of digital reaction time. Randomly occurring visual tasks was presented. The readings was analyzed}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2024, title = {A cross sectional study on vaccination coverage of COVID-19 in rural slums of field practice area of a medical college in Hyderabad}, author = {Nadia Moazzam Hussain and Rajesh Neeluri and Sultan Rizwan Ahmad }, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/12570/7571}, doi = {10.18203/2394-6040.ijcmph20241504}, issn = {2394-6032}, year = {2024}, date = {2024-05-30}, urldate = {2024-05-30}, journal = {International Journal of Community Medicine and Public Health}, volume = {11}, issue = {6}, pages = {2389–2394}, abstract = {Background: The COVID-19, a global pandemic, first identified in the Hubei province (Wuhan), China in December, 2019 is caused by SARS-CoV-2. Attempts of containing it there failed, causing it to spread to other regions of Asia and eventually around the whole world in 2020. To control the risk of transmission, non-pharmaceutical interventions were taken up by the governments all over the world. Subsequently, vaccines were developed which were administered. Vaccine hesitancy has become a significant barrier in various countries due to expeditious pace of vaccine development. Hence, this study was conducted to estimate the COVID-19 vaccination coverage in rural slums of field practice area of a medical college in Hyderabad. Methods: A community based cross sectional study was conducted between January 2023 to March 2023 in field practice area of RHTC of a medical college in Hyderabad. Data was collected from 400 eligible participants, who were selected by simple random sampling, using a predesigned, pretested structured questionnaire. Data was entered in Microsoft Excel and analysed using SPSS Version 20. Chi square test was applied. Results: In the present study, 60% of the study participants had taken COVID vaccine. Vaccination coverage was high i.e., 65.35% among 18-28 years of age group, 82.2% in females, 62.66% in Muslims, 85.71% in graduates, 80.90% in semi-skilled workers and 77.77% in upper middle socioeconomic class. Conclusions: The COVID-19 vaccination coverage was low in rural slums. Age, gender, religion, education, occupation and socioeconomic status are important determinants of COVID-19 vaccination.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Haqqani_2024, title = {Novel stop‑gain TSC2 gene mutation in an Indian child of tuberous sclerosis complex}, author = {Ruhi Haqqani and Sidra Rana and Nayeem Sadath Haneef and Omar Farooq and Vadlamudi Raghavendra Rao}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265763/pdf/IDOJ-15-657.pdf}, doi = {10.4103/idoj.idoj_469_23}, isbn = {2229-5178}, year = {2024}, date = {2024-05-20}, urldate = {2024-05-20}, journal = {Indian Dermatology Online Journal}, volume = {15}, number = {pmid39050051}, issue = {4}, pages = {657-659}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Ayesha_2024, title = {Emission of electromagnetic rays from mobile phones cause dysfunction of thyroid gland}, author = {Humera Ayesha and Shaikh Mahmood}, url = {https://www.ijsr.net/getabstract.php?paperid=ES24515081512}, doi = {10.21275/es24515081512}, issn = {2319-7064}, year = {2024}, date = {2024-05-05}, urldate = {2024-05-05}, journal = {International Journal of Science and Research (IJSR)}, volume = {13}, issue = {5}, pages = {1151-1153}, publisher = {International Journal of Science and Research}, abstract = {During the past decade, there is a dramatic increase in wireless communication system particularly the mobile phones (cell phones) which are low power single channel two ways radios that emit signals through electromagnetic waves. As most of the physiological functions in our body is regulated by electric currents and the electromagnetic fields (EMF) emitted from the mobile phones may affect the physiological processes and associated health effects like sleep disorders, headaches, etc. When we discuss about the endocrine system the most exposed vital endocrine glands when compared to pineal, pituitary, adrenal which can get affected by the electromagnetic fields is thyroid gland, an important endocrine glands that control our body metabolism which is located in front of the neck and release hormones into the bloodstream. It secretes thyroxine (T4), triiodothyronine (T3) and calcitonin. To synthesize thyroid hormones thyroid gland needs Iodine, too little or too much iodine can affect the level of hormones and its release. Role of thyroid hormones is to control metabolism, body temperature, breathing, heart rate, brain development, mental activity, digestion, fertility, etc. This study shows a higher TSH level (Hypothyroidism) with low T4 in mobile phone users. It may be concluded that there can be deleterious effects of mobile phones through electromagnetic rays on Hypothalamo-Pituitary-Thyroid axis (HPT).}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2024b, title = {Acute necrotizing encephalopathy of childhood (ANEC) in a patient with dengue and leptospirosis}, author = {Reshma Sultana Shaik and Sandhya Manorenj and Sravan Kumar Marupaka}, url = {https://journals.lww.com/neur/fulltext/2024/03000/acute_necrotizing_encephalopathy_of_childhood.43.aspx}, doi = {10.4103/ni.ni_984_21}, issn = {0028-3886}, year = {2024}, date = {2024-04-30}, urldate = {2024-04-30}, journal = {Neurology India}, volume = {72}, number = {pmid38691496}, issue = {2}, pages = {433-434}, abstract = {None}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2024c, title = {Cervicomedullary compression in achondroplasia: a feared complication and an unforeseen risk factor of posterior circulation stroke}, author = {Reshma Sultana Shaik and Sandhya Manorenj and Sravan Kumar Marupaka}, url = {https://journals.lww.com/neur/fulltext/2024/03000/cervicomedullary_compression_in_achondroplasia__a.31.aspx}, doi = {10.4103/ni.ni_537_21}, issn = {0028-3886}, year = {2024}, date = {2024-04-30}, urldate = {2024-04-30}, journal = {Neurology India}, volume = {72}, number = {pmid38691484}, issue = {2}, pages = {399-402}, abstract = {Achondroplasia is an autosomal dominant disorder with defect in the ossification of the cartilage of long bones. Many bony abnormalities constitute its clinical features, with craniovertebral junction (CVJ) anomalies being one of most common issues which need to be addressed at the earliest. CVJ anomalies in individuals may cause neurovascular compression, which may warrant an early surgery to prevent catastrophic complications. Posterior circulation strokes secondary to CVJ anomalies are well known. We hereby present an unusual case of posterior circulation stroke in an achondroplastic dwarf who presented to our tertiary care centre. Prospective case study. The present case adds to the existing literature about one of the preventable causes of fatal posterior circulation strokes in the young. A high index of suspicion for neurovascular compression at the foramen magnum and early initiation of treatment in achondroplastic young individuals may have gratifying results.}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Khoraishi_2024, title = {Case report of Gradenigo syndrome}, author = {Faezah Khoraishi and Sakeena Hussain and Summaya Fatima and Imtiaz Ahmed Khan and Syeda Ayesha}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/case-report-of-gradenigo-syndrome_April_2024_5682851671_2013202.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2024}, date = {2024-04-30}, urldate = {2024-04-30}, journal = {International Journal of Scientific Research}, volume = {13}, issue = {4}, pages = {13-14}, abstract = {Background: Back in 1900's, Gradenigo reported a series of patients with suppurative otitis media presenting with headache, unilateral eye pain and restricted lateral gaze of ipsilateeral side. Chronic ear infections spreading to temporal bone extends to the petrous apex which is the hub for 5th and 6th cranial nerves. We present one such case of a 19 year old male with history of chronic otiti Case: s media who presented with acute onset of retro-orbital pain, headache and diplopia. patient with chronic ear discharge who present with crani Conclusion: al nerve involvement, one must suspect intracranial extension. Management with appropriate antibiotics can change the course of the condition. }, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024c, title = {A neurologist’s perspective of approach to falls in the elderly}, author = {Sandhya Manorenj and Reshma Sultana Shaik}, url = {https://journals.lww.com/aomd/fulltext/2024/07010/a_neurologist_s_perspective_of_approach_to_falls.2.aspx}, doi = {10.4103/aomd.aomd_56_22}, issn = {2590-3446}, year = {2024}, date = {2024-04-29}, urldate = {2024-04-29}, journal = {Annals of Movement Disorders}, volume = {7}, issue = {1}, pages = {3-12}, abstract = {Falls constitute an important public health problem that impact the quality of life of an individual. Falls contribute to disability, especially among older adults and elderly individuals. Recurrent fallers are those who fall one or more times per year. The purpose of this article is to provide a detailed systemic qualitative review of the recent definition of falls, their mechanism, risk factors, classification; falls in neurodegenerative disorders; and their approach and management. Sources of literature were drawn from peer-reviewed original and systematic review articles published until January 2024 in the PubMed database using the following key words: falls, elderly, definition, management, etiology, neurodegenerative diseases, epilepsy and fall, dementia and fall, and prevention and diagnostic tests for postural instability and falls. This review summarizes the current understanding of falls and provides a pragmatic and clinically focused approach to their management. Falls are usually multifactorial. Neurodegenerative disorders such as cognitive decline and parkinsonism lead to increased risk of falling. There are several tools to assess the risk of early falls. A multidisciplinary approach is needed in the management of falls. The main goal is encouraging physical activity, home hazard modification, management of postural hypotension, and underlying neurodegenerative diseases.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Basha_2024, title = {A study of clinical and functional outcome of total hip replacement in avascular necrosis of femoral head}, author = {Md. Jaan Basha and Palakurthi V and Nagnur MI and Bari MA and Danish MF and Mohiuddin MA}, url = {https://www.healthcare-bulletin.co.uk/article/volume-14-issue-2-pages1029-1035-ra/}, issn = {2042-4892}, year = {2024}, date = {2024-04-24}, urldate = {2024-04-24}, journal = {European Journal of Cardiovascular Medicine}, volume = {14}, issue = {2}, pages = {1029-1035}, abstract = {BACKGROUND: This study was conducted to examine the recovery times following cemented or uncemented total hip arthroplasty for patients with avascular necrosis of the femoral head and to examine the clinical and functional outcomes of cemented versus uncemented total hip replacements in patients with this agonizing condition. METHODS: This was a 17-month study that took place in a hospital setting and involved 30 patients with hip joint arthritis brought on by avascular necrosis of the femoral head. The patients gave written informed consent and the approval of the institutional ethics committee before being referred to the Department of Orthopedics at the Princes Esra Hospital/Deccan College of Medical Sciences, Hyderabad, Telangana, India. RESULTS: Before surgery, the mean functional gait score was 10.53±6.96, and after surgery, it was 30.33±2.31. Prior to surgery, the functional activity score was 5.17±1.62, and following surgery, it was 11.40±1.07. The study group's preoperative and postoperative scores showed statistically significant variation. The average Harris hip score was 32.27±8.11 before surgery and 92.60±3.16 after surgery. The differences in scores before and after surgery were statistically significant. Before surgery, the study group's mean ROM score was 2.40±1.25, and after surgery, it was 4.63±0.49. In the preoperative and postoperative phases, there was a statistically significant difference in ROM evaluations. CONCLUSION: The current generation of uncemented implants used in total hip replacement for AVN-caused hip arthritis yields, satisfactory clinical and radiological outcomes after a reasonable period of follow-up. Despite a few problems with the course of treatment, functional and clinical outcomes have been good to exceptional overall.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Ali_2024c, title = {Green anti-biofilm agents: A mini-review}, author = {Shireen Adeeb Mujtaba Ali}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/green-anti-biofilm-agents-a-mini-review/MzkyNDU=/?is=1&b1=0&k=1}, doi = {10.36106/ijar/6802147}, issn = {2249-555X}, year = {2024}, date = {2024-04-01}, urldate = {2024-04-01}, journal = {Indian Journal of Applied Research}, volume = {14}, issue = {4}, pages = {53–57}, publisher = {World Wide Journals}, abstract = {Microbial bio-film is the polymeric matrix formed by coordinated assembly of species of similar or different microorganisms. The bacteria in form of bio-films are more resistant to drugs than compared to their planktonic counterparts, hence making it difficult to deal with bio-film-associated nosocomial and medical device infections. Around $11 billion is annual expenditure reported to be employed in healthcare to deal with bio-film infections but the success rates are very low. Studies on natural anti-bio-film agents from the last two decades notably demonstrated their bio-film modulation properties. Therefore, present state of affairs demands active pursual for non-toxic natural anti-bio-film agents. In this mini-review article, we summarize green anti-bio-film agents: antimicrobial peptides (AMPs), phytochemicals, biosurfactants, nanoparticles, and weak organic acids (WOA) with a brief note on their mode of action.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Zoheb_2024, title = {High blood pressure, hyperlipidemia, type 2 diabetes with prior history of atrial fibrilation caused stroke}, author = {Mohammed Zoheb and Deeba Rana and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/high-blood-pressure-hyperlipidemia-type2-diabetes-with-prior-history-of-arterial-fibrilation-caused-stroke/NTUzMDY=/?is=1&b1=&k=}, issn = {2277-8179}, year = {2024}, date = {2024-04-01}, journal = {International Journal of Scientific Research}, volume = {13}, issue = {4}, pages = {1-2}, abstract = {The stroke cases are on rise, to know its causes, symptoms & treatment patients have to be studied in detail and get the appropriate result. Stroke is a serious medical condition that can sometimes be deadly. Stroke cases are emerging at a startling rate at the moment. People with specific medical problems are more susceptible to stroke, even though it may affect anybody. A stroke or brain stroke can be fatal and result from inadequate blood supply to a portion of the brain, according to the Cleveland Clinic. The most common causes of this are cerebral hemorrhage or arterial obstruction. If insufficient blood flow occurs, oxygen-starved brain cells begin to die. A stroke may happen to anybody, at any age, although certain people are more susceptible than others. Furthermore, beyond the age of 65, the danger rises. Strokes occur commonly in either sex. Strokes are the second largest cause of mortality worldwide. Not only that, but stroke is a leading global cause of disability. The following are a few examples of stroke symptoms paralysis on one sides peaking difficulties or loss of speech distorted or double vision (diplopia) inability to coordinate light headedness and vomiting stiff neck personality shift agitation or confusion seizure loss of memory headache loss of consciousness the blood clotting disorder atherosclerosis Heart abnormality (ventricular or atrial septal defect) microvascular ischemia elevated blood pressure tumors of the brain (including cancer)Heart abnormality (ventricular or atrial septal defect) microvascular ischemia elevated blood pressure tumors of the brain (including cancer) etc.}, keywords = {Neurology, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hyder_2024, title = {Effect of smartphone usage during night time on sleep patterns of young adults: A cross-sectional observational study}, author = {Safa Hyder and Sudhir Shankar Mane and Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin}, url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2024&month=April&volume=18&issue=4&page=CC01&id=19291}, doi = {10.7860/jcdr/2024/66874.19291}, issn = {0973-709X}, year = {2024}, date = {2024-04-01}, urldate = {2024-01-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {18}, issue = {4}, pages = {CC01-CC06}, publisher = {JCDR Research and Publications}, abstract = {Introduction: Excessive smartphone usage among adolescents and young adults has been consistently linked to poor sleep. Moreover, smartphone overuse has been associated with daytime tiredness, longer sleeps latency, and reduced sleep duration. The significance of addressing poor sleep among adolescents and young adults is underscored by recent research linking it to adverse physical and psychological health outcomes, such as mood disturbances, impaired cognitive function, and increased risk incidence of hypertension and diabetes. Aim: To evaluate the effects of smartphone usage on sleep quality among individuals using Pittsburgh Sleep Quality Index (PSQI) and hypnogram data. Materials and Methods: In this cross-sectional observational study, sleep patterns were assessed using the PSQI questionnaire and Prime Nap sleep tracker app (version 1.1.4). The study was conducted by Deccan College of Medical Sciences, Hyderabad, Telangana, India. The data was collected in the form of a hypnogram and the study was conducted in the participants’ homes (under domicile conditions) in the city of Hyderabad, Telangana, India from March 2020 to April 2020. A total of 60 participants (both male and female) in the age group of 15-25 years were recruited and divided into two groups: one comprising 30 individuals with regular prolonged exposure to smartphone screens at night, and the other consisting of 30 individuals who experienced minimal or no smartphone exposure once they prepared to sleep. Descriptive statistics were applied to the collected data using Microsoft Excel and IBM Statistical Package for Social Sciences (SPSS) for Windows version 25.0. Results: Adding up the average scores of the seven factors gives a global PSQI score from 0 to 21, with 0-4 indicating good sleep and 5-21 indicating poor sleep. Among those who used smartphones regularly at night time, 20 participants (66.67%) had PSQI score >5 and poor sleep quality, 24 participants (80%) had prolonged sleep latency, 18 participants (60%) had poor sleep duration, 27 participants (90%) had sleep disturbances, and 22 participants (73.33%) had increased daytime dysfunction. Hypnogram abnormalities were seen in >15 participants (50%) of subjects. Conclusion: The prevalence of smartphone addiction is widely acknowledged in the medical literature, highlighting the need for its assessment, especially among adolescents and young adults. The study reveals that poor sleeping habits among participants were attributable either to a lack of awareness or neglect. By recognising the importance of adequate sleep, improvement in the quality of daily activities can be made by reducing daily screen time, consequently alleviating both physical and mental stress. Furthermore, the findings have implications for individuals whose work involves prolonged exposure to computer screens, especially during night time.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khalid_2024, title = {A hospital-based study of prostate biopsy results in Indian males }, author = {Mohd. Khalid and Mohammed Mustafa Khan and Qader Ahmed Jalily and Dinesh Eshwar Mummareddi and Saritha Sirangi and Sri N S Avinash Dande}, url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC11086797/pdf/JFMPC-13-984.pdf}, doi = {10.4103/jfmpc.jfmpc_1339_23 }, issn = {2249-4863}, year = {2024}, date = {2024-03-31}, urldate = {2024-03-31}, journal = {Journal of Family Medicine and Primary Care}, volume = {13}, issue = {3}, pages = {984-989}, abstract = {Introduction: The prostate is a gland belonging to the male reproductive system. Aging results in the dysfunction of the prostate that may present as inflammation, enlargement, and cancer. Additionally, the diseases of the prostate including cancers are slow in progression, and therefore, it is difficult to diagnose them early. Hence, it is increasingly important for physicians to recommend histopathological examination of the prostate gland to identify, manage, and treat prostate cancers. This study was conducted to assess prostate diseases among biopsy specimen collected from patients with signs of prostate diseases. Materials and methods: This prospective study was conducted in the Department of Pathology, Deccan College of Medical Sciences, Owaisi Hospital, Hyderabad, between June 2012 and September 2014. All gross specimens (n = 300) of the prostate such as the needle biopsies of the prostate, transurethral resection of the prostate (TURP) chips, and excised specimens of the prostate were included in the study. Histopathological examinations of the biopsies were performed for nuclear size, chromatin material, nucleoli, membrane thickness, irregularity, cytoplasmic granularity, staining, and cell border conspicuity. The biopsies were also assessed for lobule formation, secretions, polymorphonuclear leukocytes, lymphocytes, macrophages, connective tissue stromal cells, their arrangements, and acellular connective tissue material. Results: Of 300 total prostatic biopsies performed, 56 (18.66%) were identified as inflammatory lesions of the prostate (prostatitis), 98 (32.66%) revealed benign prostatic lesions (benign prostatic hyperplasia (BPH)), 112 (37.33%) were identified as BPH with premalignant lesions, and 34 (11.33%) were revealed as malignant tumors of the prostate. Chronic prostatitis (67.85%) was the common inflammatory lesion. The majority (91.42%) revealed epithelial lesions compared to stromal lesions (08.58%). BPH was predominantly (28.00%) noticed among patients in the age group of 61-70 years. Prostatic intraepithelial neoplasia (PIN) was observed majorly (53.35%) in the age group of 61-70 years. Most of the prostatic cancers were identified as adenocarcinomas. However, three variants were also categorized as small cell carcinoma, signet ring cell carcinoma, and transitional cell carcinomas. Conclusions: The results reveal that prostatic adenocarcinomas are predominant among the study population. Additionally, prostatic diseases including cancer are commonly noticed among people belonging to the age group of 61-70 years. More than one-third of patients showed BPH with premalignant lesions, and a majority of the study population showed evidence of chronic prostatitis.}, key = {pmid38736835}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2024, title = {To explore the effectiveness of problem-based learning over conventional didactic lecture in microbiology for phase 2 MBBS students}, author = {Sarwat Fatima and Mohammed Sarosh Ahmed and Madhipati Sai Krishna and Maimoona Mustafa and Shahbaz Sajjad}, url = {https://www.iosrjournals.org/iosr-jrme/papers/Vol-14%20Issue-1/Ser-2/D1401022630.pdf}, doi = {10.9790/7388-1401022630}, issn = {2320–737X}, year = {2024}, date = {2024-02-20}, urldate = {2024-02-20}, journal = {IOSR Journal of Research & Method in Education}, volume = {14}, issue = {1 (Series 2)}, pages = {26-30}, abstract = {Background:Problem based learning [PBL] has been identified and approved by many medical educationists as one of the best teaching learning methods due to the fact that it improves students’ learning in all 3 domains and improves higher order thinking. Research has found its positive effect to be variable in different geographic settings. Aim & objectives: To explore the effectiveness of PBL over conventional lecture. To evaluate students’ performance using PBL rubrics. To determine student’s acceptance and perceptions of PBL. Material& methods: the present study is a prospective experimental and interventional type. The IERB approval was obtained and project was pilot tested. Study participants were enrolled by verbal consent and sampled using quota and randomisation method. The sequential steps of the study include: orientation on PBL method, pre-test, a questionnaire on preparedness for self-directed learning [SDL], conduct of sessions by 2 different TL methods with exchange of groups, post-test, students grading and lastly general feedback. Statistical methods: Mean ± SD, unpaired t test and 5-point Likert scale was used for analysis of results. Results: Around 114 /147 [77.55%] enrolled and continued till the end. The overall mean scores for DL & PBL method of teaching were as 1.65 ± 0.53 & 1.70 ± 0.62 in pre-test and 6.84 ± 1.22 and 7.36 ± 1.07 in post-test with p values as 0.178 & 0.118. For individual topics in post-test the PBL group secured higher scores than DL except for one. The assessment and feedback on PBL gave variable results. Discussion &Conclusion: the present study couldn’t find any statistically significant difference in the learning outcomes while using 2 different TL methods. However, the questionnaire on SDL preparedness, assessment and feedback data revealed certain grey zones which demand further enquiry into students learning plans & preferences which could be one of the reasons for the outcome observed and open doors for future qualitative research. Limitations: students and faculty related factors besides study design might have influenced the outcomes observed. }, keywords = {Community Medicine, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2024, title = {Compare the anti-hypertensive efficacy of oral labetalol and oral nifedipine in mild preecclampsia}, author = {Surayya Tahseen and Juveriya and Hafsa Younus and Amtul Aziz Safiya and Sofia Sumain and Asma Hafeez}, url = {https://www.ijmedph.org/Uploads/Volume14Issue1/65.%20[182._IJMEDPH_Jafar]%20356-364.pdf}, doi = {10.5530/ijmedph.2024.1.65}, issn = {2230–8598}, year = {2024}, date = {2024-02-20}, urldate = {2024-02-20}, journal = {International Journal of Medicine and Public Health}, volume = {14}, issue = {1}, pages = {356-364}, abstract = {Background: Aim: This study is to compare the anti-hypertensive efficacy of Tablet Labetalol and Tablet. Nifedipine in mild preeclampsia. Material and Methods: The study was conducted at the Deccan College of Medical Sciences (Owaisi Hospital and Research Centre and Princess Esra Hospital) both the hospitals attached from January 2021 to June 2022. 100 antenatal women with mild preeclampsia were selected. Informed consent taken. 50 women were given Tablet Labetalol. 50 women were treated with Tablet Nifedipine. Results: This study was conducted on a total of 100 antenatal mild preeclamptic women to compare the anti-hypertensive efficacy of T. Labetalol and T. Nifedipine. The maternal and fetal outcomes were also studied. Patients were divided into two groups 50 each. Group A Received T. Labetalol and group B received T. Nifedipine. Blood pressure and feto maternal status were serially monitored. Termination was done at 37 completed weeks gestation or when the patient progressed to severe preeclampsia. The average dose required for T. Labetalol was 300 mg and 30 mg for T. Nifedipine. In both the groups, all 50 patients had adequate control of blood pressure. Inspite of adequate control the disease progressed in both groups. In group A (T. Labetalol) 14% progressed to severe pre-eclampsia. In group B (T. Nifedipine) 20% progressed to severe pre-eclampsia. Among the babies delivered, in group A 86% were term babies and 8% required SNN admission. In group B 80% were term babies and 10% required SNN admission. Comparing the two groups, group B had significantly higher number of side effects when compared to group A. None of the patients developed grave complications such as HELLP syndrome, pulmonary edema, coagulopathy, postpartum collapse, eclampsia. The maternal mortality was nil. Thus when patients with preeclampsia are identified and treated atan earlier stage the morbidity and mortality associated with preeclampsia can be significantly reduced. Conclusion: From this study it is prudent that both T. Labetalol and T. Nifedipine are equally efficacious in the control of hypertension in mild preeclampsia.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024b, title = {Ictal nystagmus in a patient with nonketotic hyperglycemia: a rare clinical phenomenon of occipital epilepsy}, author = {Sandhya Manorenj and Deepika Venniveli and Mounika E. Reddy and Srujana Billa}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941902/pdf/AIAN-27-77.pdf}, doi = {10.4103/aian.aian_800_23}, issn = {0972-2327}, year = {2024}, date = {2024-02-06}, urldate = {2024-02-06}, journal = {Annals of Indian Academy of Neurology}, volume = {27}, number = {pmid38495234}, issue = {1}, pages = {77-79}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2024, title = {Knowledge of stroke and the window period for thrombolytic therapy in ischemic stroke among South Indians: a hospital-based survey with educational intervention}, author = {Reem Jaffer Ali and Sandhya Manorenj and Ruqya Zafar}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927053/?report=printable}, doi = {10.25259/JNRP_312_2023}, issn = {0976-3147}, year = {2024}, date = {2024-02-05}, urldate = {2024-02-05}, journal = {Journal of Neurosciences in Rural Practice}, volume = {15}, number = {pmid38476435}, issue = {1}, pages = {111-116}, abstract = {Objectives: The objective of this study was to determine the awareness of stroke in regards to the risk factors, warning symptoms, and knowledge of the therapeutic window period among varied strata of non-medical people attending a tertiary care center. Materials and Methods: The interventional study involved the collection of data regarding awareness of stroke using a structured questionnaire with a total score of 16. Pre-intervention assessment was followed by intervention in the form of education regarding awareness of stroke administered one-on-one for personalized and effective comprehension by subjects. Then, subjects were asked to recall the information that was delivered to them and were scored accordingly. Results: Among the 500 subjects included, 51% were female. About 76.8% of participants were young (age <50 years), and 83.4% were literate. Only 25.4% of participants were aware of the brain as the site of stroke. About 32.2% of candidates were aware of a few risk factors for stroke. Among them, the majority of participants were aware of hypertension (24%) as a risk factor. The most known warning symptom was “Numbness” or weakness of arm. The majority of the subjects (97.8%) were unaware of a therapeutic window period for stroke being 4.5 h or below. The mean pre-intervention score was 2.52 ± 1.65 while the mean post-intervention score was 15.10 ± 1.79 (P < 0.0001). Conclusion: The study showed that even among literate participants, only a meager number of subjects were aware of the golden window period of intravenous thrombolysis. Educational intervention by means of an in-person and one-on-one explanation achieved significant levels of understanding of stroke. The study could be used to formulate large-scale educational programs that focus on spreading awareness of symptoms and risk factors while also instilling the importance of timely medical intervention for efficient thrombolytic therapy.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Murthy_2024, title = {To study down staging locally advanced breast carcinoma: the role of neoadjuvant chemotherapy}, author = {T. S. R. Murthy and Mohammed Arshad Ali Khan and M. R. Madhu Mohan Reddy}, url = {https://jcdronline.org/index.php/JCDR/article/view/13551/7466}, doi = {10.48047/jcdr.2024.15.01.217}, issn = {0975-3583}, year = {2024}, date = {2024-01-31}, urldate = {2024-01-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {15}, issue = {1}, pages = {1944-1951}, abstract = {Introduction: Although rare, locally progressed breast cancer is a major obstacle for clinicians. This study was conducted because there is a direct correlation between the pathological response to neoadjuvant chemotherapy and disease free survival. This study was out to evaluate the histological impact of neoadjuvant chemotherapy on breast cancer patients with locally advanced disease. Material and Methods: This study was observational based study. The research was carried out at the Department of General Surgery, Deccan College of Medical Sciences, Hyderabad, Telangana, India. The study was done from September 2022 to July 2023. A total of twenty-five people were used as subjects in this research. Modified radical mastectomy was performed after clinical evaluation of tumour response and patient follow-up. Pathological reaction was assessed and notes were made on the specimen. Result: People in their 50s and 60s made up the bulk of the population. The majority of the 30 patients with locally advanced cancer (73%), ranging from stage IIIA to stage IIIB, were men.Nearly half of the patients tested positive for oestrogen receptors but negative for HER2, and a quarter of those individuals tested positive for all three.Everyone who tested positive for HER 2 was also considered to be a triple negative. Both the ER and PR positive tumour percentages were 67%.Forty percent of tumours tested positive for HER2. Possible explanations for the low response rate and high rate of ER positive include the fact that 83% of patients did not react to NACT and only 17% demonstrated a pathological response. Conclusion: Better prognosis may be possible if we could determine which tumours would respond best to which treatments. Recent developments in cancer biology and genetic profiling have the potential to revolutionise the clinical management of LABC by allowing for a more targeted and personalised approach.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2024, title = {Evaluation of the pathological response to neoadjuvant chemotherapy in locally advanced breast cancer}, author = {M. R. Madhu Mohan Reddy and Yasaswi Ponnapalli and Md. Samiuddin}, url = {https://jcdronline.org/index.php/JCDR/article/view/13553/7467}, doi = {10.48047/jcdr.2024.15.01.218}, issn = {0975-3583}, year = {2024}, date = {2024-01-31}, urldate = {2024-01-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {15}, issue = {1}, pages = {1952-1958}, abstract = {Background and objective: To assess how patients with locally advanced breast cancer respond pathologically to neoadjuvant therapy. It is uncommon to have locally advanced breast cancer (LABC), and it poses significant clinical challenges. The purpose of the study was to look into the relationship between disease-free survival and the pathological response to neoadjuvant chemotherapy. Method: An observational study was conducted at Department of General Surgery, Deccan College of Medical Sciences, Hyderabad, Telangana, India from December 2022 to November 2023. on a sample of 40 persons to assess the pathological response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. The study received ethical approval from the committee. Result: Between the ages of 50 and 60, 33% of the population fell. About half of the patients exhibited negative human epidermal growth factor receptor 2 (HER2), positive progesterone receptor (PR), and positive oestrogen receptor (ER). Sixty-seven percent of tumours tested positive for both the progesterone receptor (PR) and the oestrogen receptor (ER). Forty percent of the tumours had HER2 positive results. Merely 17% of the patient cohort exhibited a pathological reaction to neoadjuvant chemotherapy (NACT). 83% of the total did not respond.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Samiuddin_2024, title = {An investigation of the antibiotic sensitivity of peritoneal fluid cultures in cases of perforative peritonitis}, author = {Md. Samiuddin and M. R. Madhu Mohan Reddy and Mallika Anjum}, url = {https://www.jcdronline.org/admin/Uploads/Files/65b63b946af163.82910711.pdf}, doi = {10.48047/jcdr.2024.15.01.222}, issn = {0975-3583}, year = {2024}, date = {2024-01-31}, urldate = {2024-01-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {15}, issue = {1}, pages = {1982-1989}, abstract = {Introduction: Peritonitis is a prevalent issue encountered by General surgeons. Significant advancements in the treatment of peritonitis have occurred in recent decades, primarily through the utilisation of antibiotics and surgical interventions. The objectives of the study were to ascertain the antibiotic sensitivity and resistance pattern for routinely utilised antibiotics against the cultured microbes. Material and Methods: This study was conducted using a cross-sectional design. The research was carried out at the Department of General Surgery, Deccan College of Medical Sciences, Hyderabad, Telangana, India. The study was done from October 2022 to September 2023. This study utilised a sample of 40 persons as subjects. Result: A common complication of perforation of the hollow viscus is secondary peritonitis. Because patients sometimes do not arrive at the hospital until much later, the fatality rate is significant. The age groups of 31–40 years old and 20–30 years old accounted for the bulk of the perforation cases in our study. The average age at which symptoms first appear is 35.26 years. Based on our findings, the second half of the duodenum accounts for 52% of perforations, whereas the stomach accounts for 42%. Among the organisms developed, Klebsiella accounted for 46% of the cases, E. coli for 34%, and just 2% displayed a combination of the two. Our study focused on analysing the sensitivity patterns of organisms that were cultivated. Ceftriaxone, ciprofloxacin, and amikacin were the most commonly found organisms that demonstrated sensitivity. Conclusion: The study found that the most common site of perforation is the duodenum, followed by the stomach. Peptic ulcer illness was the most common cause. The most common bacteria responsible for secondary peritonitis in these patients were Klebsiella and Escherichia coli, with mixed, proteus, and pseudomonas infections occurring very rarely. Cephalosporins, quinolones, and macrolides were the most effective antibiotics against Klebsiella and Escherichia coli, in that order of sensitivity.}, note = {Article not available}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Khan_2024, title = {Pyogenic granuloma mistaken as papilloma}, author = {Imtiaz Ahmed Khan and Mohammed Naseeruddin Mujahid and Mohammed Adnan Rahmani and Juwairiya Sadaf and Romana Khatoon}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/pyogenic-granuloma-mistaken-as-papilloma_January_2024_1174007484_3711536.pdf}, doi = {10.36106/ijsr}, isbn = {2277-8179}, year = {2024}, date = {2024-01-31}, urldate = {2024-01-31}, journal = {International Journal of Scientific Research}, volume = {13}, issue = {1}, pages = {23}, abstract = {NA}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2024, title = {Usual to unusual vascular complications encountered during endovascular management of renal biopsy complications}, author = {Zoya Shaik and Sravan Kumar Marupaka and Jampala Venkateshwarlu}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/article/usual-to-unusual-vascular-complications-encountered-during-endovascular-management-of-renal-biopsy-complications/MjgxODc=/?is=1}, doi = {10.36106/gjra/5107582}, issn = {2277-8160}, year = {2024}, date = {2024-01-15}, urldate = {2024-01-01}, journal = {Global Journal for Research Analysis}, volume = {13}, issue = {1}, pages = {136–137}, publisher = {World Wide Journals}, abstract = {Percutaneous renal biopsy is widely used for diagnosis, prognosis, and management of nephropathies. Early identification and embolization of the involved artery aids in effective management of the vascular complications and defers the need for nephrectomy. In this study, we aimed to evaluate various vascular injuries after renal biopsy requiring interventions. Pseudoaneurysm was the most common form of arterial injury. Target vessel was identified by angiography and successful embolization was done deferring nephrectomy. Deaths occurred due to hemorrhage.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2024, title = {A comprehensive analysis of clinical characteristics, microbial profile, prognostic indicators, and treatment in patients with type 2 diabetes mellitus and acute pyelonephritis}, author = {Syed Faiz Ahmed and Mohammed Khaja Arifuddin}, url = {https://jcdronline.org/index.php/JCDR/article/view/13317/7351}, doi = {10.48047/jcdr.2024.15.01.55}, issn = {0975-3583}, year = {2024}, date = {2024-01-11}, urldate = {2024-01-11}, journal = {Journal of Cardiovascular Disease Research}, volume = {15}, issue = {1}, pages = {496-505}, abstract = {Background: Pyelonephritis is frequently linked to diabetes mellitus, serving as a common cause. Poor outcomes are associated with both emphysematous pyelonephritis (EPN) and non-emphysematous pyelonephritis (NEPN). This study was conducted to examine the clinical characteristics, microbiological profile, prognostic factors, and treatment outcomes of pyelonephritis specifically in diabetic patients. Methods: Acute pyelonephritis is considered present when a patient experiences fever with chills, rigors, flank pain, nausea, and vomiting. A diagnosis is confirmed through USG and KUB studies showing an enlarged kidney, collection presence, and perinephric fat stranding. Urine samples are collected through midstream voiding, catheterization, or suprapubic needle aspiration. A positive urine culture indicates >105 CFU/ml of bacteria. Glycemic control is classified as good (HbA1c <7%), moderate (HbA1c 7-7.5%), or poor (HbA1c >7.5%). Emphysematous pyelonephritis classification is based on CT scan findings. Results: In a study of 40 patients with acute pyelonephritis and type 2 diabetes, 80% had non-emphysematous pyelonephritis (NEPN) and 20% had emphysematous pyelonephritis (EPN). Over 75% in both groups experienced loin pain, a hallmark of acute pyelonephritis. Burning micturition affected 75% of EPN and 28.12% of NEPN patients. Less than 15% reported decreased urine output and vomiting in both groups. The NEPN group had significantly lower rates of burning micturition, possibly indicating a link to pyelonephritis severity. In EPN patients, 75% had normal CECT KUB findings, with 50% of abnormalities falling into Class 3A. Approximately 50% of both groups were treated without IV antibiotics, with conservative management dominating. Other interventions, including DJ stents, antifungals, hemodialysis, percutaneous nephrolithotomy, and ureteroscopy with stenting, were also employed. Conclusion: Diagnosing emphysematous pyelonephritis (EPN) in diabetic patients with pyelonephritis symptoms, particularly with poorly controlled blood sugars, requires a high suspicion index and early imaging. Most affected individuals are aged 51-70 years. Cases of both non-emphysematous (NEPN) and EPN are predominantly associated with gram-negative bacteria. EPN patients in Class I-IIIA respond well to antibiotics or additional percutaneous drainage (PCN), while Class IIIB and Class IV cases may require nephrectomy.}, keywords = {General Medicine, Urology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2024, title = {An interesting case of chronic isolated apathetic syndrome}, author = {Sandhya Manorenj and Rindha V. Rao and Reshma Sultana Shaik}, url = {https://sciencevolks.com/neurology/pdf/SVOA-NE-05-0124.pdf}, doi = {10.58624/SVOANE.2024.05.0124}, issn = {2753-9180}, year = {2024}, date = {2024-01-10}, urldate = {2024-01-10}, journal = {SVOA Neurology}, volume = {5}, issue = {1}, pages = {37-40}, abstract = {An apathy syndrome is defined as a syndrome of primary motivational loss, that is, loss of motivation not attributable to emotional distress, intellectual impairment, or a diminished level of consciousness. The main anatomical correlate of apathy is the medial frontal lobe. Here we report a case of a 49-year-old male who presented with a history of lack of interest for the past 10 months without any other neurological symptoms. He was diagnosed with depression and was receiving treatment from multiple psychiatrists. In view of his persistent symptoms, he approached us and was evaluated. Examination showed anosmia with apathy that paved the way to the orbitofrontal location of the lesion. Psychiatric symptoms may be an unusual presentation of a space-occupying lesion of brain. Strong suspicion and imaging the brain is indicated in all cases to prevent the unnecessary use of psychiatric medicines and their complications. }, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Mahmood_2025, title = {Correlation between histopathological grades of oral squamous cell carcinoma and tobacco consumption a cross sectional assessment}, author = {Aiman Mahmood and Hafeza Syeda Farha Sultana and Idrees Akhtar Afroze}, url = {https://www.makhillpublications.co/files/published-files/mak-rjms/2024/4-147-151.pdf}, doi = {10.36478/makrjms.2024.4.147.151}, issn = {1815-9346}, year = {2024}, date = {2024-01-06}, urldate = {2024-01-06}, journal = {Research Journal of Medical Sciences}, volume = {18}, issue = {4}, pages = {147-151}, abstract = {Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer associated with tobacco consumption. Histopathological grading provides insights into the aggressiveness and prognosis of OSCC. This study aims to explore the correlation between the histopathological grades of OSCC and the history and extent of tobacco consumption in patients. A cross‐sectional study was conducted with 200 participants diagnosed with OSCC. Histopathological grades were determined using standard criteria and were correlated with detailed tobacco consumption history, including duration, frequency and type. Statistical analyses were conducted to assess the relationship between the grades of OSCC and tobacco use patterns. The study found a statistically significant correlation between higher histopathological grades of OSCC and increased levels of tobacco consumption. A noticeable pattern of more severe carcinoma grades was evident among heavy and long‐term tobacco users. The results also highlighted specific histopathological characteristics that were more prevalent in association with certain types and patterns of tobacco use. The findings suggest a strong link between tobacco consumption and the severity of histopathological grades of OSCC. These results underscore the critical need for targeted tobacco cessation programs and early screening for OSCC, especially among populations with high tobacco use. Further research is recommended to explore the mechanisms underlying the relationship between tobacco‐induced carcinogenesis and OSCC progression.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Tabassum_2024, title = {Assessment of HER2 amplification in breast carcinoma: a cross‐sectional study comparing IHC and Fish}, author = {Jasmeen Tabassum and Lubna Yasmeen and Idrees Akhtar Afroze}, url = {https://makhillpublications.co/files/published-files/mak-rjms/2024/113-117.pdf}, doi = {10.59218/makrjms.2024.3.113.117}, issn = {1815-9346}, year = {2024}, date = {2024-01-03}, urldate = {2024-01-03}, journal = {Research Journal of Medical Sciences}, volume = {18}, pages = {113-117}, abstract = {This cross‐sectional study aims to compare the effectiveness of Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH) in assessing HER2 amplification in breast carcinoma, which is pivotal for treatment strategy and prognosis. The study encompassed 200 patients diagnosed with breast carcinoma. HER2 status was initially assessed using IHC. Cases with equivocal or positive IHC results were further evaluated using FISH to confirm HER2 gene amplification. Statistical analysis was conducted to determine the concordance and discordance between the two methods. The results demonstrated a certain percentage of cases showing HER2 amplification. Concordance rates between IHC and FISH were high, with some discordant results analyzed to understand the causes. The study provided detailed figures on the sensitivity, specificity and predictive values of IHC in comparison to FISH, discussing the implications of these findings in clinical practice. This study underscores the significance of a complementary diagnostic strategy combining both IHC and FISH for the reliable determination of HER2 status in breast carcinoma. The findings advocate for an integrated approach to enhance accuracy, improve treatment decisions and ultimately, patient outcomes in breast cancer care.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Shireen_2024, title = {Prevalence of high grade dysplasia in colorectal polyp cross sectional analysis in tertiary care hospital}, author = {Sumaiya Shireen and Sumayya Aijaz and Idrees Akhtar Afroze}, url = {https://makhillpublications.co/files/published-files/mak-rjms/2024/100-103.pdf}, doi = {10.59218/makrjms.2024.3.100.103}, isbn = {1815-9346}, year = {2024}, date = {2024-01-02}, urldate = {2024-01-02}, journal = {Research Journal of Medical Sciences}, volume = {18}, issue = {3}, pages = {100-103}, abstract = {The incidence of colorectal cancer had been increasing globally, with high‐grade dysplasia in colorectal polyps recognized as a significant precursor to malignancy. This study aimed to determine the prevalence of high‐grade dysplasia among patients with colorectal polyps in a tertiary care hospital setting.A cross‐sectional study was conducted involving 300 patients who underwent colonoscopy and were diagnosed with colorectal polyps at a tertiary care hospital. The presence of high‐grade dysplasia was confirmed through histopathological examination. Data regarding patient demographics, polyp characteristics and histological findings were collected and analyzed. The study found that high‐grade dysplasia was present in a significant proportion of colorectal polyps, particularly among patients aged 50 years and older, with a prevalence of 30% compared to 13.3% in younger patients. The odds of high‐grade dysplasia were notably higher in polyps >10mm in size (OR = 2.3) and located in the colon (OR = 1.9). Gender did not show a significant association with the presence of high‐grade dysplasia. Additionally, while an increasing number of polyps showed a higher prevalence of high‐grade dysplasia, this association did not reach statistical significance. All findings were statistically analyzed to ascertain the strength and significance of these associations, with age, polyp size and location showing notable correlations with the occurrence of high‐grade dysplasia in colorectal polyps. This study provided valuable insights into the prevalence of high‐grade dysplasia in colorectal polyps in a tertiary hospital setting. The findings informed clinicians and health policymakers about the importance of screening and surveillance strategies in the early detection and prevention of colorectal cancer.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2023b, title = {A prospective study on surgical management of closed distal end femoral fracture in adults using distal femur locking compression plate}, author = {Syed Hameed Ahmed and Patlolla Karthik Reddy and Sindhe Vinayak Rao}, url = {https://ijphrd.com/issues.html}, doi = {10.37506/ijphrd.v14i4.19827}, issn = {0976-0245}, year = {2023}, date = {2023-12-31}, urldate = {2023-12-31}, journal = {Indian Journal of Public Health Research & Development}, volume = {14}, issue = {4}, pages = {330-335}, abstract = {Background: Distal Femur fractures are a highly incident complex case and pose a challenge to the treating orthopedician. Aims and Objectives: The aims and objectives of this study were to To assess radiological union of distal femoral fractures by open reduction and internal fixation with locking compression plate, To study the functional outcome for internal fixation of fractures of the distal end femur by Locking Compression Plate and To evaluate the effectiveness and complications of distal end femur fractures treated with Locking Compression Plate based on, time till union, rate of infection, and fixation failures, functional outcome using NEER’S SCORE. Materials and Methods: The present study was done from April 2017 to April 2018 which comprised of fifteen patients with closed Distal end Femoral Fractures who where treated by Locking Compression plate. Overall final outcome was assessed in terms of radiological union, clinical assessment and regaining the lost knee function using NEER’S Score. Results: Out of 15 patients, 12 patients were males and 3 patients were females.Out of 15 patients, 14 were due to RTA. Maximum number of cases was of Muller type C2-60%. Internal fixation was considered after patients general and medical condition was stabilized. The average operative time was 90 minutes. The size of plate was selected based on the type of fracture. 6 to 10 hole plate were used most commonly. Of 15 patients, 10 (66.66%) showed radiological union within 16 weeks. 9 (60%) of the patients achieved weight bearing at the end of 14 weeks. Average flexion in this study was 100 degree with more than 3 (20%) patients having knee range of motion more than 110 degree. 1 Patient had stiff knee. More than 80% patients were extensor lag less than 5 degree. 2 patients had VARUS MALALIGNMENT out of 15 patients.Results according to NEER’S SCORE were Excellent in 20% patients, Good in 60%, Satisfactory in 6.6% and unsatisfactory in 13.3% patients. 2 patients had superficial infection and 1 patient had delayed union. Conclusion: Locking compression plate is an optimal tool for Distal end femoral fractures. It provides rigid fixation in the region of femur, where a wide canal, thin cortices and frequently poor bone stock make fixation difficult.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2023b, title = {Effects of tuberculosis on genitourinary system}, author = {Mohammed Khaja Arifuddin and Syed Faiz Ahmed}, url = {https://www.jcdronline.org/index.php/JCDR/article/view/4016/3895}, doi = {10.48047/jcdr.2023.14.12.265}, issn = {0975-3583}, year = {2023}, date = {2023-12-31}, urldate = {2023-12-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {14}, issue = {12}, pages = {2291-2299}, abstract = {Background: Genitourinary Tuberculosis (GUTB) is a common site of extrapulmonary tuberculosis. The disease involves the kidneys, ureters, bladder, or genital organs. Clinical symptoms develop 10 – 15 years after primary infection. Only one-quarter of patients with GUTB have a known history of TB and about half of these patients have chest radiography findings. The current study aimed to determine the effects of GUTB. Methods: The included patients were successive cases with a diagnosis of genitourinary tuberculosis. A total of 62 cases were reported with the diagnosis of genitourinary tuberculosis. PCR for MTb was done in 37 cases. Radiological evaluation included chest X-ray, KUB in all cases, and intravenous urogram when serum creatinine was normal. FNAC was performed in cases with serosal masses. All patients received antitubercular drug therapy with 4 drugs (Rifampicin, Ethambutol, Isoniazid, and Pyrazinamide) for 2 months followed by 2 drugs (Rifampicin and Isoniazid) for 7 months. Results: Positive AFB staining and positive MTb culture in urine were seen in 31.37% and 41.17% of cases, respectively, confirming the presence of Mycobacterium tuberculosis in some GUTB patients. Positive PCR for MTb in urine is present in 67.56% of cases (in a subset of 37 patients). MTb culture in pus is only observed in 4 out of 7 cases, suggesting its less frequent occurrence compared to other positive findings. Sterile urine is found in 78.95% of cases, and Radiological abnormalities (IVU/NCCT/MUCG) suggestive of GUTB was found in 46/57 (80.7%) cases. Bladder biopsy was positive in 12/25(48%) cases done. A comparison of urinary PCR with urine for AFB staining urine for MTb culture and bladder biopsy was done. Conclusion: The urinary (PCR) stands out as the most sensitive indicator among all microbiological tests. When coupled with radiological abnormalities, it significantly expedites the diagnosis of genitourinary tuberculosis. Optimal treatment involves a combination of multidrug chemotherapy and judicious surgery, as necessary. It is highly advisable to make every effort to reconstruct the urinary tract due to the rewarding outcomes associated with this approach. However, in cases where tissue is infected and irreparably damaged, the most effective course of action is ablating the affected tissue.}, keywords = {General Medicine, Urology}, pubstate = {published}, tppubtype = {article} } @article{Jahangir_2023, title = {Study of route of delivery and perinatal outcome in oligohydramnios}, author = {Juveria Jahangir and Anjum Kehkeshan and Summaiyah Yousuf and Yusra Siddiqui and Rana Siddiqui}, url = {https://www.academicmed.org/Uploads/Volume5Issue6/285.%20[2114.%20JAMP_Anjum]%201385-1387.pdf}, doi = {10.47009/jamp.2023.5.6.285}, issn = {2687-5365}, year = {2023}, date = {2023-12-31}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {5}, issue = {6}, pages = {1385-1387}, abstract = {Background: To study neonatal outcome and appropriate route of delivery in oligohydramnios of AFI < 5 cm in women at or beyond 34 weeks gestation. Methods: In this prospective case control study of 50 women (study group) with oligohydramnios of AFI < 5 cm at or beyond 34 weeks of gestation was compared with 50 women (control group) with normal AFI > 5 cm and less than 25 at or beyond 34 weeks matched for age, parity, gestational age. Women with PROM, gestational age < 34 weeks and greater than 40 weeks, congenital anomaly, PIH, multiple gestations were excluded from this study. This study was done in antenatal and intrapartum period for neonatal outcome and appropriate route of delivery. Results: In our study we found that oligohydramnios was associated with increased rate of non-reassuring fetal heart rate (25% Vs 6%), cesarean delivery (50% Vs 10%), low birth weight (60% Vs 25%), FGR (17% Vs 5%) and admission to NICU (15% Vs 5%). There was no neonatal death in the study. Conclusion: Pregnancies with isolated oligohydramnios (AFI <5 cm) at or beyond 34 weeks are associated with increased incidence of fetal distress (non-reassuring fetal heart rate), caesarean delivery, and low birth weight. Induction of labor was associated with increased rate of caesarean section due to fetal distress. No appropriate route of delivery can be recommended for isolated oligohydramnios.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Jahangir_2023b, title = {Comparison between misoprostol and dinoprostone in inducing labor}, author = {Juveria Jahangir and Anjum Kehkashan and Yusra Siddiqui and Summaiyah Yousuf and Syeda Shaheera}, url = {https://www.academicmed.org/Uploads/Volume5Issue6/286.%20[2115.%20JAMP_Anjum]%201388-1391.pdf}, doi = {10.47009/jamp.2023.5.6.286}, issn = {2687-5365}, year = {2023}, date = {2023-12-31}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {5}, issue = {6}, pages = {1388-1391}, abstract = {Background: The objective of this study was to evaluate safety and efficacy of labour inducing prostaglandins E1 and E2. We compared the obstetrical outcomes of intra-vaginal misoprostol (PGE1) and intra-cervical dinoprostone gel (PGE2) in our study. Materials and Methods: The study included 100 full term pregnant women of 19 to 30 years age group, with a cephalic presentation of single live fetus. Fifty women were included in each group (study and control). Women in study group were given 50 micrograms of Misoprostol intravaginal, while the control group received 0.5 mg of intracervical dinoprostone gel each. Key parameters studied in both groups were average time taken for start of labour, induction time at birth, duration of delivery, oxytocin requirement and delivery method. Conclusion: In comparison to dinoprostone, our study found misoprostol to be a better option in inducing labour for both the mother and the fetus, due to its efficacy, safety, and affordability.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Study to determine the common substances that caused deaths due to ingestion brought for autopsy in tertiary care hospital, Hyderabad, Telangana, India}, author = {Mohammed Abdul Mujeeb Siddiqui and Zahraa Mohammed Siddiqui and Azra Siddiqui and Katkuri Parvathi}, issn = {2393-915X}, year = {2023}, date = {2023-12-31}, journal = {International Journal of Contemporary Medical Research}, volume = {10}, issue = {12}, pages = {L1-L5}, abstract = {Background: This study was conducted to know the common substances that caused deaths by ingestion, brought for autopsy to Osmania General Hospital, Hyderabad, Telangana State, India for a period three years. The cases of deaths due to poisoning were selected from the autopsies conducted and analyzed for the most commonly ingested substance. Material and methods: The samples were collected for three consecutive years from January 2012 to December 2014. The contents of the stomach were examined grossly and the samples were collected in three containers during autopsy for each individual case. Portion of stomach and its contents, portions of liver, kidney, blood and body fluids were collected labeled and sent to the State Forensic Science Laboratory for analysis of unknown poison. The reports were analyzed. The data collected was arranged according to age, sex and substances detected. Results: A total of 1196 cases of poisoning in three years were studied. Most of the deaths occurred, were due the ingestion of Organophosphates. It is the commonest insecticide used by farmers in fields. The common age group involved is between 21 years to 30 years ingesting organophosphates. In the deaths due to poisonings, men are predominantly involved compared to women. Conclusion: In the study it was concluded that the ingestion of poisonous substance organophosphate is usually intentional and is used to commit suicide. In children it is mostly accidental. Poison can also be used as homicide to kill a person.}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Basha_2023, title = {A study of management of fracture tibia with iliazarov external fixation}, author = {Md. Jaan Basha and Syed Hameed Ahmed and Tarannum Sultana and Mohammed Abdul Bari and Mohammed Rameezuddin Siddiqui and Mohammad Abid Hussain and Zeeshan Sajid}, url = {https://healthcare-bulletin.co.uk/article/a-study-of-management-of-fracture-tibia-with-ilizarov-external-fixation-1448/}, issn = {2042-4884}, year = {2023}, date = {2023-12-30}, urldate = {2023-12-30}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {4}, pages = {1362-1367}, abstract = {Treatment for high-energy tibial fractures is challenging because they involve open wounds or significant degloving injuries, articular depression, condylar displacement, and the separation of comminuted metaphysis from diaphysis. Using periarticular fine wires in minimally invasive techniques lets small pieces of cancellous bone and intra-articular fractures be fixed in place. These techniques also make it easy to keep an eye on the wound, allow early joint mobilisation and weight bearing, and cause little damage to soft tissues. Materials and Methods: This was an observational study conducted at the Department of Orthopaedics and Traumatology, Owaisi Hospital and Research Center which is attached to Deccan College of Medical Sciences Hyderabad between June 2021 to June 2023 involving a total of 18 cases of complex proximal and distal tibia treated with an Ilizarov ring fixator. The Rasmussen radiological grading system, the Karlsson and Peterson ankle function score, and the Knee Society scoring system were used to evaluate the patients. Results: One patient was 20 years old, six were between the ages of 21 and 30, six were between the ages of 31 and 40, and five were over 40. 17 patients were males, and only one was female. Eleven individuals with tibial platue fractures achieved functional outcomes and an excellent to good knee score. One patient had a fair knee score and functional results. In 3 tibial shaft fractures, 2 had excellent results and 1 had a good result. In 3 pilon fractures, 2 had excellent results and 1 had good results. In our research, three of the eighteen patients experienced a pin tract infection, which resolved with localised antibiotic dressings. One of these patients experienced a pin-tract infection recurrence right before the fixator was supposed to be removed. Conclusion: Complex tibial fractures caused by high-energy injuries are seen more frequently in males in the 3rd and 4th decades. Ilizarov external fixation with the use of olive wires gives excellent clinical and functional results in their management with lesser complication rates compared to internal fixation.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Unnisa_2023, title = {Effect of physical activity on glycated hemoglobin [HbA1c] in non-diabetic individuals}, author = {Arshiya Unnisa and Farah Bahmed and Farisa Khatoon and Mehnaaz Sameera Arifuddin and Nazia Uzma}, url = {https://journals.lww.com/jdyu/fulltext/2023/12030/effect_of_physical_activity_on_glycated_hemoglobin.15.aspx}, doi = {10.4103/jdrysruhs.jdrysruhs_24_22}, issn = {5555-6666}, year = {2023}, date = {2023-12-27}, journal = {Journal of Dr. YSR University of Health Sciences}, volume = {12}, issue = {3}, pages = {285-290}, abstract = {Introduction: Physical inactivity is a rapidly evolving public health issue that contributes to a wide range of chronic diseases and health consequences, including obesity, diabetes, and cancer. In addition to improving a patient’s overall health, increased physical activity has been demonstrated to be beneficial in the management of chronic conditions. The purpose of this research is to discover if there is a link between physical activity intensity and HbA1c levels in non-diabetic adults and, if so, which type of physical activity has the most impact on glycemic control. Material and Methods: There were 90 healthy non-diabetic individuals in the study. The International Physical Activity Questionnaire (IPAQ) score was calculated after each subject’s physical activity questionnaire was evaluated. Based on their IPAQ scores, the participants were split into three groups: low, moderate, and vigorous physical activity. A 3 mL blood sample was taken in a vacutainer to determine HbA1c levels. The data was produced in Microsoft Excel and analyzed using the statistical application SPSS 17.0. Result: HbA1c values were statistically significant in the moderate-physical-activity group, while IPAQ showed a statistical difference between males and females in the vigorous-physical-activity group. In all three groups, IPAQ scores were significantly different but not in HbA1c levels. The HbA1c and IPAQ scores had a modest negative connection. The difference between males and females in our study was statistically insignificant. The body mass index (BMI) and HbA1c, as well as BMI and IPAQ, were found to have a positive linkage. Conclusion: Physical activity, particularly moderate-to-vigorous activity, has a bigger influence on non-diabetic people’s glycemic regulation.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Mirza_2023, title = {A case report-astasia abasia treated with faradic stimulation}, author = {Samia Mirza and Khan Mohammad Zeeshan Ali and Saad Mohiuddin and Minhajzafar Nasirabadi}, url = {https://journals.lww.com/tjima/abstract/2023/03020/a_case_report___astasia_abasia_treated_with.14.aspx}, doi = {10.52314/tjima.2023.v3i2.135}, year = {2023}, date = {2023-12-22}, urldate = {2023-12-22}, journal = {Telangana Journal of IMA}, volume = {3}, issue = {2}, pages = {55-57}, abstract = {Conversion disorder presents with a wide variety of symptoms, one of the rarest presentations being Astasia-Abasia; where the individual loses their ability to stand or walk normally without any apparent anatomic or physiologic abnormality. psychosocial stressors have been observed to closely precede the onset of symptoms. Management of conversion disorders centres around psychoeducation and psychotherapy but the response is slow and varied. This case report describes one such case of a 13-year-old female with Astasia-Abasia who was successfully treated with Faradic stimulation.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Nasirabadi_2023b, title = {Charting a legacy of excellence and community empowerment:the odyssey of IMA Hyderabad city branch}, author = {Minhajzafar Nasirabadi and Srirang Abkari and Khan Mohammed Zeeshan Ali }, url = {https://www.tjima.org/journal/index.php/tjima/article/view/121/211}, doi = {10.52314/tjima.2023.v3i2.121}, year = {2023}, date = {2023-12-22}, urldate = {2023-12-22}, journal = {Telangana Journal of IMA}, volume = {3}, issue = {2}, pages = {1-3}, abstract = {NA}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2023, title = {A study to compare administration of dexmedetomidine and fentanyl for stress attenuation during laryngoscopy and endotracheal intubation}, author = {Syed Asrar Hussain and Khaja Ali Hassan and Hafsa Mehveen and Mohammed Irfan and Anwesh Farhana}, url = {https://academicmed.org/Uploads/Volume5Issue6/129.%20[1952.%20JAMP_Irfan%20Mohammed]%20625-628.pdf}, doi = {10.47009/jamp.2023.5.6.129}, issn = {2687-5365}, year = {2023}, date = {2023-12-15}, urldate = {2023-12-15}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {5}, issue = {6}, pages = {625-628}, abstract = {Background: Haemodynamic changes like hypertension and tachycardia occurs in response to instrumentation of larynx and trachea during direct laryngoscopy & endotracheal intubation. This is mainly due to reflex sympathetic stimulation. This is usually transient and variable, and is well tolerated by healthy individuals. However, these changes may be fatal in patients with hypertension, coronary artery disease and intracranial hypertension. Materials and Methods: Study – randomized, double blind, prospective. Ethical committee approval - obtained from Institute, Written informed consent - obtained from all the patients. 30 patients belonging to ASA I and II of both sexes divided into two groups(n=15) undergoing surgery under general anaesthesia were randomly selected for study. Patients of either sex with ASA I and II between 20 to 50 years of age undergoing surgeries were taken into study. Result: From our study, we observed that fentanyl attenuated but did not fully abolish the pressure response to laryngoscopy and intubation. Also we adequately establish that Dexmedetomidine 0.75 μg/kg was comparatively superior in attenuation of the haemodynamic changes during direct laryngoscopy. Conclusion: We conclude that Fentanyl when given before laryngoscopy and intubation was not fully effective in attenuating the sympathetic response, while Dexmedetomidine efficiently attenuates the haemodynamic changes to laryngoscopy and endotracheal intubation. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Naaz_2023, title = {Clinico-pathological correlation of inflammatory dermatoses in a tertiary care hospital}, author = {Farha Naaz and Naushaba Tazeen and Mohammed Mustafa Khan and Idrees Akhtar Afroze and Khatija Shameem and Atiya Begum and Asiya Tabassum and Sobia Afreen}, url = {https://jcdronline.org/index.php/JCDR/article/view/4062/3938}, issn = {0975-3583}, year = {2023}, date = {2023-12-06}, urldate = {2023-12-06}, journal = {Journal of Cardiovascular Disease Research}, volume = {14}, issue = {12}, pages = {2525-2534}, abstract = {Inflammatory dermatoses encompass a variety of histologic patterns that affect different segments of the skin. Skin is a complex organ having many functions. Epidermis with melanocytic system, dermis with adnexa and subcutis are its main components. Skin diseases are highly prevalent in developing countries, occur commonly amongst all age groups and range from simple inflammatory lesions to fatal neoplasms. As clinical presentation can be similar for various skin lesions, histopathological examination remains the gold standard for accurate diagnosis and serves as a guide to clinician for appropriate management. The objective of this study is to observe and analyze the spectrum of inflammatory dermatological lesions through Histopathological examination. Through this we try to find out the common skin lesions in an urban population, evaluate its correlation with age and gender, and correlate the clinical diagnosis and histopathological examination. Out of 50 skin biopsies studied, 31 were female and 19 were male. Age of the patients range from 11 to 70 years in which peak age was 21-30 years. Leprosy is the most common lesion in our study accounting for 16 out of 50 cases studied. Next common lesion was Psoriasis, accounting for 10 out of 50 cases studied. Out of these 50 cases, 44 cases correlated with clinical diagnosis and the rest of cases did not correlate with given clinical diagnosis. The present study emphasizes the role of histopathological examination as a valuable diagnostic tool to understand the pathology of inflammatory dermatoses and provides a significant insight into trend of inflammatory skin lesions in the specific sub-population of Hyderabad, Telangana, India.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2023d, title = {Morphometric study of human brain ventricles by magnetic resonance imaging in Indian population: a retrospective study}, author = {Zafar Sultana Abdul Saleem and Farah Bahmed and Syeda Sadia Sameera and Sravan Kumar Marupaka and Habib Khan Gulab Khan Pathan}, url = {https://journals.lww.com/jdyu/fulltext/2023/12020/morphometric_study_of_human_brain_ventricles_by.15.aspx}, doi = {10.4103/jdrntruhs.jdrntruhs_210_22}, issn = {5555-6666}, year = {2023}, date = {2023-12-01}, urldate = {2023-12-01}, journal = {Journal of Dr. YSR University of Health Sciences}, volume = {12}, issue = {2}, pages = {171-177}, abstract = {Introduction: Ventricular parameters are used to study hydrocephalus, schizophrenia, tumors, trauma, Alzheimers disease, gender, aging and atrophy associated with many neurological diseases as stroke and dementia, to assess loss of brain parenchyma. Normal reference values of brain ventricles obtained by MRI are necessary to create baseline data for interpreting pathological changes, planning surgery and determining presence and progress of some neurological disorders. Materials and Method: This is a retrospective, cross sectional and non-interventional study. we have studied 100 brain MRI digital images. Following parameters have been studied frontal horn width [FHW], transverse internal diameter of skull[TIDS-F] at same level, frontal horn ratio[FHR], frontal horn length on both sides [FHLR & FHLL], total length of lateral ventricle on both sides [LVLR & LVLL], posterior horn width [PHW], transverse internal diameter of skull at same level [TIDS-P], fourth ventricle width [FVW] and fourth ventricle anteroposterior distance [FVAP]. SPSS. version. 21 was used for statistical analysis. Results: There were 54 females and 46 males between age 20 years to above 60 years. Frontal horn width, posterior horn width and total inner diameter of skull at frontal and posterior level has shown significant gender differences with P value as 0.0034,0.0004,0.00013 and 0.0004 respectively. Frontal horn ratio, total length of right and left lateral ventricles and total inner diameter of skull has shown significant increase with age. Conclusion: The normal reference values of ventricles obtained from MRI are necessary to form baseline data, for interpreting pathological changes and planning surgeries.volumetric measurements will provide more information than linear measurements.}, keywords = {Anatomy, Pediatrics, Physiology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Chaitanya_2023, title = {The study of first‐trimester vaginal bleeding and its maternal and perinatal outcomes at a tertiary care center in Hyderabad}, author = {N. Chaitanya and Tamatam Deepthisri and Rohin}, url = {https://journals.lww.com/mjhs/fulltext/2023/11040/the_study_of_first_trimester_vaginal_bleeding_and.4.aspx}, doi = {10.4103/mjhs.mjhs_82_22}, issn = {2321-7006}, year = {2023}, date = {2023-12-01}, urldate = {2023-12-01}, journal = {MRIMS Journal of Health Sciences}, volume = {11}, issue = {4}, pages = {239-243}, abstract = {Background: Among all those pregnancies with first-trimester vaginal bleeding, nearly half of them terminate into a pregnancy loss. In case the pregnancy continues, it may result in some complications such as intrauterine growth retardation (IUGR), preterm prelabor rupture of membrane (PPROM), preterm delivery, placental abruption, and preeclampsia. Objective: The objective was to study the pregnancy outcomes in first-trimester vaginal bleeding. Materials and Methods: This retrospective observational study was done on 100 antenatal women who attended our hospital for delivery and had a history of first-trimester vaginal bleeding. All women were evaluated for pregnancy outcomes including pregnancy-induced hypertension, anemia, abruption, preterm labor, premature rupture of membrane (PROM), PPROM, IUGR, and placenta previa and neonatal outcomes in the form of birth weight and APGAR score. Results: Ninety-nine percentage of cases had viable outcome, and only one case had abortion after 20 weeks. Sixteen percentage had fetal growth restriction (IUGR), fifteen percentage had anemia, 14% had preterm labor, 12% had gestational hypertension, 11% had PROMs, 4% had preterm PROMs, and 2% had placental abruption and placenta previa. Among 16 patients who developed IUGR, 31% had abnormal Doppler and 69% had normal Doppler. Sixty percentage of patients delivered after 37 weeks. One case each of postpartum hemorrhage and perinatal death were observed. Conclusions: First-trimester vaginal bleeding is an important factor in predicting late pregnancy maternal and fetal outcomes. These pregnancies should be considered high risk, and antenatal care should be given carefully. Pregnant women need to be trained regarding the associated complications and their timely management.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Karan_2023b, title = {The effect of durative computer usage on intraocular pressure}, author = {Siddharth Karan and Sheetal Baldava and Rahel Afzal and Farheen Fatima and Saira Begum}, url = {https://www.ijlbpr.com/uploadfiles/29vol12issue4pp162-165.20231019052727.pdf}, issn = {2250-3137}, year = {2023}, date = {2023-10-31}, urldate = {2023-10-31}, journal = {International Journal of Life Sciences Biotechnology and Pharma Research}, volume = {12}, issue = {4}, pages = {162-165}, abstract = {Aim: To investigate the changes in the Intraocular pressure (IOP) in adults on prolonged computer usage. Methods:31 adult subjects working with computers for prolonged hours had their Intraocular pressure checked with Schiotz tonometer. Measurements were taken initially on every individual before computer usage and then following 3 hours of computer usage. Results: There was significant rise in the Intraocular pressure (Mean Increase of Intraocular pressure is 1.23mm of Hg) in most of the myopic subjects after 3 hours of continuous usage of computer. Conclusions: Prolonged computer usage could induce transient Intraocular pressure elevation. Mostly Intraocular pressure elevation is seen in myopic subjects whereas emmetropic subjects showed little or no elevation.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2023b, title = {Association between Candida albicans and COVID-19 in complete denture wearers: An observational study}, author = {Mohd. Osman Ali and Babashankar Alva and Suresh Nagaral and Rohit Patil and Mohammad Ullah Khan and Durgesh A. Tiwari}, url = {https://www.cureus.com/articles/200623-association-between-candida-albicans-and-covid-19-in-complete-denture-wearers-an-observational-study#!/}, doi = {10.7759/cureus.47777}, issn = {2168-8184}, year = {2023}, date = {2023-10-27}, journal = {Cureus}, volume = {15}, issue = {10}, pages = {e47777}, abstract = {Introduction: The phenomenon of coronavirus disease 2019 (COVID-19)-related candidiasis is gaining increased attention and acknowledgment as an integral component of the severe consequences of COVID-19. The aim of the present study was to assess the association between Candida albicans and COVID-19 in complete denture wearers. Materials and methods: An observational study was conducted on 45 complete denture wearers, who were divided into three groups as follows: Group 1, 15 subjects with mild to moderate COVID-19 infection; Group 2, 15 subjects with severe COVID-19 infection; and Group 3, 15 subjects without COVID-19 infection. Mean colony forming units (CFU) were observed on agar plates containing Sabouraud dextrose in the salivary samples of the participants. Analysis of variance, followed by post-hoc analysis by Tukey’s test, was used to compare CFU between the groups. Pearson’s correlation coefficient was used to study the correlation between variables. Results: The highest average colony-forming units of Candida albicans were observed in Group 2, followed by Group 1, compared to the control group, and a significant (p<0.001) difference was found. A weak positive correlation was found between the age of the patients and the duration of denture usage, as well as between age and the counts of Candida albicans in Groups 1 and 3. This correlation was more pronounced in Group 3. A strong positive correlation was observed in all groups between the Candida albicans count and the duration of denture usage by the patients. Conclusion: The association between Candida albicans and denture wear was compounded by the presence of COVID-19. Consequently, the timely identification of Candida albicans infection in patients with COVID-19 is important to establish more efficacious approaches for antifungal treatment and prophylactic interventions.}, keywords = {Dentistry}, pubstate = {published}, tppubtype = {article} } @article{Quadri_2023, title = {A study of factors affecting and outcomes in difficult total knee arthroplasty}, author = {Saadullah Khan Quadri and Mohammed Akram and Mohammed Siddique Mohiuddin and Mohammed Abdul Bari and Mohammed Abid Hussain and Mohammed Firdouse and Asapanna Naga Sai Venkata Yeshwanth}, url = {https://healthcare-bulletin.co.uk/article/a-study-of-factors-affecting-and-outcomes-in-difficult-total-knee-arthroplasty-1259/}, doi = {10.5083/ejcm}, issn = {2042-4884}, year = {2023}, date = {2023-10-20}, urldate = {2023-10-20}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {4}, pages = {306-312}, abstract = {Background: This prospective observational study was undertaken to look into the factors that affect the outcome of total knee arthroplasty and the short-term results of total knee replacements in complex knee pathologies. Methods: This prospective observational study was conducted between 2021 and 2023 at Owaisi Hospital and Research Centre, Hyderabad. A consecutive series of 12 total knee arthroplasties was performed on 12 patients at our institute using PFC Sigma endoprosthesis. The patients were assessed clinically and radiologically using the INSALL scoring system. Results: The average pre-operative range of motion (flexion) was 45˚, with a highest of 120˚ and a lowest of 0˚. The average post-operative flexion was 102˚, with a highest of 130˚ and a lowest of 90˚. The average extension lag preoperatively was 18˚, and the average postoperative extension lag was less than 10˚. The average pre-operative knee score was 64.84, with the highest score of 91 and the lowest score of 40. The majority of the patients had a score in the range of 51–100. The average post-operative knee score was 136.84, with the highest score of 160 and the lowest score of 120. A majority of the patients had an improvement in score in the range of 101–150. At 6 months, follow-up relief was excellent in most patients; only 10 patients had anterior knee pain, and all the patients were able to walk more than 50 blocks post-operatively without any walking aid. Conclusion: Determining the factors resulting in a difficult knee helps in formulating an appropriate surgical approach, which results in a better functional outcome following total knee arthroplasty.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Iqubal_2023, title = {Study of testosterone levels in type II diabetes mellitus male patients in Telangana population}, author = {Mohammed Asif Muzaffer Iqubal and Mohammed Mudassir Ali and Mohammed Muneer Ahmed and Juwairia Mohammed Fariduddin}, url = {http://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue10,Article54.pdf}, issn = {0975-1556}, year = {2023}, date = {2023-10-19}, urldate = {2023-10-19}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {15}, issue = {10}, pages = {309-313}, abstract = {Background: Type-II DM affects millions of people in India and globally, but the association between serum testosterone levels (STL) and type-II DM is still unclear, but it impairs reproductive health and quality of life. Method: 95 (ninety-five) type II DM patients of different age groups were studied and compared with 90 normal (controlled) groups. The blood investigation included FBS, PP Blood sugar, Blood urea, serum creatinine, HBA1C, lipid profile, urine albumin, creatinine ratio, serum testosterone were estimated by chemiluminesience immune assay and HbA1c by HPLC. Results: The BMI, age, HBA1C, and serum testosterone level were compared with the control group, and the p value was highly insignificant (p<0.001). Conclusion: The present pragmatic study has confirmed that type II DM patients have significantly lower testosterone and higher sugar level was proved.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2023b, title = {Management of femoral neck fractures using cemented bipolar prosthesis}, author = {Patlolla Karthik Reddy and Syed Hameed Ahmed and Sindhe Vinayak Rao}, url = {https://makhillpublications.co/files/published-files/mak-rjms/2023/157-165.pdf}, doi = {10.59218/ makrjms.2023.11.157.165}, issn = {1993-6095}, year = {2023}, date = {2023-10-16}, urldate = {2023-10-16}, journal = {Research Journal of Medical Sciences}, volume = {17}, issue = {11}, pages = {157-165}, abstract = {Femoral neck fractures are common orthopedic injuries, particularly among the elderly. Surgical intervention is often necessary to restore mobility and alleviate pain. This study explores the management of femoral neck fractures through the use of cemented bipolar prostheses. Patient evaluation: Comprehensive assessment, including age, bone quality and medical history, is conducted to determine surgical candidacy. Radiographic imaging aids in fracture pattern assessment. Surgical Planning: Implant selection involves cemented bipolar prostheses, comprising a femoral stem and bipolar head. Surgical Procedure: Fractured femoral neck exposure, debridement, femoral canal preparation and stem cementation are executed. Bipolar head attachment permits joint articulation. Postoperative Care: Rehabilitation and weight‐bearing restrictions are crucial. Regular follow‐up and imaging monitor healing and implant performance. Clinical Outcomes: Cemented bipolar prosthesis implantation yields pain relief, improved joint stability and functional restoration. Complications: Potential complications include infection, implant loosening and dislocation, influenced by patient health and bone quality. Advantages: Cemented bipolar prostheses offer stability and mobility restoration. Challenges: Complications underscore the need for careful patient selection and postoperative care. Future Directions: Ongoing research aims to refine techniques and implant designs, enhancing patient outcomes. Management of femoral neck fractures using cemented bipolar prostheses is a valuable surgical approach, providing stability and improved quality of life. Clinical Implications: This study contributes to orthopedic knowledge, guiding clinicians in the treatment of femoral neck fractures.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Baldava_2023, title = {Observational study of the effect of ND‐YAG posterior capsulotomy on intraocular pressure, refraction and macular thickness in posterior capsular opacification}, author = {Sheetal Baldava and Siddharth Karan and Abdul Jabbar Khazi and Shifa Oosman}, url = {https://makhillpublications.co/files/published-files/mak-rjms/2023/10-78-81.pdf}, doi = {10.59218/makrjms.2023.10.78.81}, issn = {1815-9346}, year = {2023}, date = {2023-10-08}, urldate = {2023-10-08}, journal = {Research Journal of Medical Sciences}, volume = {17}, issue = {10}, pages = {78-81}, abstract = {Background: Purpose: 1) To determine the effect of Nd Yag posterior capsulotomy in pseudophakic eye on IOP and macular thickness, (2) To corelate between posterior capsular opacity and visual acuity before and after Nd Yag posterior capsulotomy and (3) To determine the duration of cataract extraction and development of posterior capsular opacity. A prospective observational study was done for the period of six months from December 2022 to May 2023 at the Department of Ophthalmology at Deccan college of medical sciences, Hyderabad. Visual acuity was recorded, detailed slit lamp examination, Kryer et al. grading system for PCO was done, IOP was measured by Goldmann applanation tonometry, detailed fundus examination with 90D, Nd Yag Q switched laser capsulotomy was done under topical anesthesia, power setting and number of exposures varied depending on thickness of posterior capsule opacity and macular thickness was measured SD OCT. BCVA, IOP andmacular thickness was measured on day 1, at one week and one month follow up. BCVA significantly improved post procedure after one week and one month. IOP and macular thickness increased post procedure but did not required any medical intervention. Time of onset of PCO after cataract surgery varied significantly, average period in our study was 3.5 years}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Sultan_2024, title = {Sporotrichoid primary cutaneous nocardiosis: a rare case of isolated upper-limb involvement in a housewife}, author = {Juhi Fatima Sultan and Fatima Razvi and Nayeem Sadath Haneef and Sarwat Fatima}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10969236/pdf/IDOJ-15-270.pdf}, doi = {10.4103/idoj.idoj_133_23}, isbn = {2229-5178}, year = {2023}, date = {2023-10-05}, urldate = {2023-10-05}, journal = {Indian Dermatology Online Journal}, volume = {15}, number = {pmid38550836}, issue = {2}, pages = {270-273}, abstract = {Nocardiosis is a rare infection due to a ubiquitous, gram-positive, weakly acid-fast, filamentous, aerobic bacteria, that are usually responsible for opportunistic infection in immunocompromised patients. Less frequently, nocardiosis can affect immunocompetent patients, causing primary cutaneous infections. Here we present a case of a 45-year-old housewife with a 12-day history of red painful nodules arranged linearly on her right upper limb, without any apparent history of injuries or comorbidities, albeit with a hobby of gardening. The unusual yet characteristic presentation, microbiological findings, and excellent response to co-trimoxazole therapy were consistent with a diagnosis of sporotrichoid primary cutaneous nocardiosis. The uncommon lymphocutaneous presentation is often misdiagnosed. Therefore, keeping a high index of suspicion in such cases is important to improve the cure rate and prevent complications. }, keywords = {Dermatology, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2023c, title = {Knowledge, attitude and practices of reproductive health among adolescent girls in field practice area of tertiary care centre, Hyderabad}, author = {Mehaboobi Shaik and Sayeedunnisa Sarah and Moniza Maheen}, url = {http://www.ijlbpr.com/uploadfiles/135vol12issue3pp694-699.20230809043213.pdf}, issn = {2250-3137}, year = {2023}, date = {2023-09-30}, urldate = {2023-09-30}, journal = {International Journal of Life Sciences, Biotechnology and Pharma Research}, volume = {12}, issue = {3}, pages = {694-699}, abstract = {Background: Adolescents form precious human resources in every country & constitute 18% of the total population in India.The majority of adolescents lack basic knowledge about puberty, growth during puberty, safe sex, and hygiene. Adolescence is a period of rapid physical growth, sexual and psychological changes. Aim: The aim of the study was to understand the knowledge, attitude regarding reproductive health and to assess the practices regarding reproductive health among school-going adolescent girls of 6th to 10th standard. Methods: It is a cross-sectional study carried out among school-going adolescent girls of standard 6 to 10 in the field practice area of a medical college in Hyderabad. The study duration was from February 2022 to January 2023. The data collection tool used for the study was a semi-structured questionnaire. The data was analysed by using SPSS 20 software. Results: Among the total of 904 participants 45.7% were scared during the first menstrual cycle. Dysmenorrhoea was most common in class IV socioeconomic status (53.7%).31.4% of study participants had occasional itching and 5.3% had continuous itching. About 10.6% of study participants consulted doctors during menstruation of which the majority of them belonged to 10 to 12 years (16.3%). 58.6% of study participants did household activities during menstruation of which the majority were studying 9th class (69.2%). Conclusion: The present study concluded that female adolescents had unsatisfactory knowledge, inadequate hygiene practices, and positive attitudes toward Reproductive Health.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2023d, title = {Health problems in school going adolescent girls in field practice area of tertiary care centre}, author = {Mehaboobi Shaik and Moniza Maheen}, url = {http://www.ijlbpr.com/uploadfiles/123vol12issue3pp630-636.20230802064005.pdf}, issn = {2250-3137}, year = {2023}, date = {2023-09-30}, urldate = {2023-09-30}, journal = {International Journal of Life Sciences, Biotechnology and Pharma Research}, volume = {12}, issue = {3}, pages = {630-636}, abstract = {Background: Adolescents form precious human resources in every country & constitute 18% of the total population in India. Adolescence is a period of rapid physical growth, sexual and psychological changes. The aim of the study is to assess the health problems and health issues in Adolescent girls. Their physical growths were also studied. Methods: It is a cross-sectional study carried out among school-going adolescent girls of standard 6 to 10 in the field practice area of a medical college in Hyderabad. The study duration was from February 2022 to January 2023. The data collection tool used for the study was a semi-structured questionnaire. The data was analysed by using SPSS 20 software. Results: Among the total of 904 participants 60.1% belong to the 13-15 years age group and the majority belonged to class II socioeconomic status i.e. 45.6%. Around 79.2% are having skin problems. Among them, 37.1% have hair fall problems and 25.6% have multiple problems. Girls with any episode of illness from the past 15 days show stomach pain at 22.9% and headache at 15.9%. Conclusion: Health problems were found during health check-ups, indicating the need for regular health services. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Deepthisri_2023, title = {Role of parenteral iron sucrose in the treatment of iron-deficiency anemia in pregnant women of gestational age 20–34 weeks}, author = {Tamatam Deepthisri and N. Chaitanya and Rohin}, url = {https://journals.lww.com/mjhs/fulltext/2023/11030/role_of_parenteral_iron_sucrose_in_the_treatment.5.aspx}, doi = {10.4103/mjhs.mjhs_68_22}, issn = { 2321-7006}, year = {2023}, date = {2023-09-30}, journal = {MRIMS Journal of Health Sciences}, volume = {11}, issue = {3}, pages = {196-200}, abstract = {Background: Anemia is responsible directly or indirectly for 40%–60% of maternal deaths from cardiac failure, hemorrhage, infection, and preeclampsia. It also increases perinatal mortality and morbidity rates consequent to preterm deliveries, intrauterine growth restriction, low iron stores, iron-deficiency anemia, and cognitive and affective dysfunction in the infant. Objective: The objective of this study is to study the efficacy of intravenous iron sucrose in terms of hemoglobin rise and side effects. Materials and Methods: Single-center, hospital-based comparative prospective study was conducted among 60 patients admitted with anemia in pregnancy with a hemoglobin concentration of 7.5–9 g/dl. Blood samples were sent for evaluation of hemoglobin, packed cell volume (PCV), and serum ferritin levels at baseline, at 4, and 8 weeks. Results: Mean age was 29.08 ± 5.74 years. About 51.7% belonged to the middle social class. Most were gravida III (36.7%). About 46.7% had 20–24 weeks of gestations. Seventy-five percent had microcytic hypochromic anemia. Hemoglobin improved significantly (P < 0.05) from 8.76 ± 0.54 g% at baseline to 11.47 ± 0.85 g% at 4 weeks, and to 12.68 ± 1.04 g% at 8 weeks; PCV also improved significantly (P < 0.05) from 26.78 ± 3.11% to 34.64 ± 3.73% at 4 weeks and again improved to 42.50 ± 4.67% at 8 weeks; serum ferritin also improved significantly (P < 0.05) from 23.06 ± 7.96 μg/l to 28.86 ± 9.79 μg/l at 4 weeks and again improved to 36.31 ± 12.53 at 8 weeks after parenteral iron sucrose therapy. Only one pregnant woman complained of vomiting and only four women complained of pain at the site of injection after giving parenteral iron sucrose therapy. About 91.6% of the women had no complaints. Conclusion: Parenteral iron sucrose therapy in pregnant women with a gestational age of 20–34 weeks with iron-deficiency anemia was found effective in improving the hemoglobin, PCV, and serum ferritin with negligible side effects.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2023d, title = {Assessment of soluble thrombomodulin and soluble endoglin as endothelial dysfunction biomarkers in seriously ill surgical septic patients: correlation with organ dysfunction and disease severity}, author = {Mohammed Affan Osman Khan and Tarun Kumar Suvvari and Syed Asif Shah Harooni and Aleem Ahmed Khan and Syyeda Anees and Bushra}, url = {https://link.springer.com/article/10.1007/s00068-023-02369-8}, doi = {10.1007/s00068-023-02369-8}, issn = {1863-9933}, year = {2023}, date = {2023-09-23}, urldate = {2023-09-01}, journal = {European Journal of Trauma and Emergency Surgery}, publisher = {Springer Science and Business Media LLC}, abstract = {Background: Sepsis, a complex condition characterized by dysregulated immune response and organ dysfunction, is a leading cause of mortality in ICU patients. Current diagnostic and prognostic approaches primarily rely on non-specific biomarkers and illness severity scores, despite early endothelial activation being a key feature of sepsis. This study aimed to evaluate the levels of soluble thrombomodulin and soluble endoglin in seriously ill surgical septic patients and explore their association with organ dysfunction and disease severity. Methodology: A case control study was conducted from March 2022 to November 2022, involving seriously ill septic surgical patients. Baseline clinical and laboratory data were collected within 24 h of admission to the Surgical Intensive Care Unit. This included information such as age, sex, hemodynamic parameters, blood chemistry, SOFA score, qSOFA score, and APACHE-II score. A proforma was filled out to record these details. The outcome of each patient was noted at the time of discharge. Results: The study found significantly elevated levels of soluble thrombomodulin and soluble endoglin in seriously ill surgical septic patients. The RTqPCR analysis revealed a positive correlation between soluble thrombomodulin and soluble endoglin levels with the qSOFA score, as well as, there was a positive association between RTqPCR soluble thrombomodulin and the SOFA score. These findings indicate a correlation between these biomarkers and organ dysfunction and disease severity. Conclusion: The study concludes that elevated levels of soluble thrombomodulin and soluble endoglin can serve as endothelial biomarkers for early diagnosis and prognostication in seriously ill surgical septic patients.}, key = {pmid37741913}, keywords = {Biochemistry, Central Research Laboratory, General Surgery, No Department}, pubstate = {published}, tppubtype = {article} } @article{Sebastian_2023, title = {Heart failure: Recent advances and breakthroughs}, author = {Sneha Annie Sebastian and Edzel Lorraine Co and Arun Mahtani and Inderbir Padda and Mahvish Anam and Swapna Susan Mathew and Ayesha Shahzadi and Maha Niazi and Shubhadarshini Pawar and Gurpreet Johal}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0011502923001141?via%3Dihub}, doi = {10.1016/j.disamonth.2023.101634}, issn = {0011-5029}, year = {2023}, date = {2023-09-12}, urldate = {2023-09-01}, journal = {Disease-a-Month}, pages = {101634}, publisher = {Elsevier BV}, abstract = {Heart failure (HF) is a common clinical condition encountered in various healthcare settings with a vast socioeconomic impact. Recent advancements in pharmacotherapy have led to the evolution of novel therapeutic agents with a decrease in hospitalization and mortality rates in HF with reduced left ventricular ejection fraction (HFrEF). Lately, the introduction of artificial intelligence (AI) to construct decision-making models for the early detection of HF has played a vital role in optimizing cardiovascular disease outcomes. In this review, we examine the newer therapies and evidence behind goal-directed medical therapy (GDMT) for managing HF. We also explore the application of AI and machine learning (ML) in HF, including early diagnosis and risk stratification for HFrEF.}, key = {pmid37704531}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Begum_2023, title = {Differential expression of Claudin-3 and Claudin-4 in endometriosis}, author = {Safia Begum and Shaik Iqbal Ahmed and Bushra and Smita C. Pawar and Aleem Ahmed Khan}, url = {https://soeagra.com/abr/abrsept2023/29.pdf}, doi = {10.15515/abr.0976-4585.14.5.218227}, issn = {0976-4585}, year = {2023}, date = {2023-09-01}, urldate = {2023-09-01}, journal = {Advances in Bioresearch}, volume = {14}, issue = {5}, pages = {218-227}, abstract = {Endometriosis is a chronic inflammatory disease that is characterized by presence of endometrial lesions in extra-uterine tissues, affecting ~ 190 million women globally. Our study investigated epithelial mesenchymal transition in different grades of endometriosis by tracking the changes as we move from grade 1 to grade 4. Furthermore we also explored the role of claudin-3 and claudin-4 in different grades of endometriosis. We found decreased expression of claudin-3 and claudin-4 in different grades of endometriosis when compared with the control group. Significant decrease in expression of claudin-3 and claudin-4 was evident in grade 3 and grade 4 endometriosis than in grade 1 and grade 2 endometriosis. Claudin being an integral part of tight junctions is inevitable for maintaining cell-cell integrity and epithelial homeostasis. Undermining the claudin-3 and claudin-4 function is assumed to play an important role in pathogenesis of endometriosis because disruption of tight junctions would set free endometrial cells for migration and invasion. Comprehending the role of claudin-3 and claudin-4 would unveil new insights into underlying molecular mechanisms in endometriosis and it also creates opportunities for designing new therapeutic approaches to treat the disease.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Mohiddin_2023b, title = {Role of Ag NOR staining in benign and malignant lesions of prostate at a tertiary hospital }, author = {Mohammed Ghouse Mohiddin and Mohammed Mustafa Khan and Mohammed Masooduddin and Asiya Tabassum}, url = {https://www.jcdronline.org/paper.php?slug=role-of-ag-nor-staining-in-benign-and-malignant-lesions-of-prostate-at-a-tertiary-hospital}, issn = {0975-3583}, year = {2023}, date = {2023-08-31}, urldate = {2023-08-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {14}, issue = {8}, pages = {2600-2608}, abstract = {Nucleolar organizing regions (NOR) can be located by staining with silver nitrate under prescribed conditions; the structures thus demonstrated termed as `AgNORs'. Nucleolar organizing regions (NOR) counts might be of helpful specifically in conditions where histological distinction of prostatic cancer is difficult. Present study was aimed to study role of AgNORs in differentiating benign from malignant lesions of prostate. Material and Methods:Present study was single-center, prospective, observational study, conducted in samples of prostatic biopsies. The diagnosis in all cases were made on H & E and subsequently taken up for study.All prostatic biopsies were stained by the modified AgNOR technique. All silver-stained structures, both intra and extra nucleolar were counted.Results: Based on the histopathological examination of prostatic biopsies, 87 were diagnosed as benign (BPH) and 13 cases were malignant (Carcinoma prostate). Maximum no. of cases of BPH are in the age group of 51 - 60 years (40.2 %) followed by 61-70 years (39.1 %). Majority cases of carcinoma prostate were from age group of 51 - 60 years (38.46 %). In the present study we have applied AgNOR staining procedure to histopathologically diagnosed cases of BPH and Ca prostate. In BPH showed a mean AgNOR count of 2.38 ± 0.31, while biopsies from carcinoma prostate had a mean AgNOR count of 5.39 ±0.408. In our study BPH constituted majority of the lesions (87% of cases). Among BPH lesions, BPH with prostatitis constituted (29 %) which obscures the AgNOR staining. Ca prostate constituted (13%). Conclusion: Prostatic disease is responsible for significant morbidity and mortality in men throughout the world. AgNOR is a simple, cost effective and easy stain to evaluate the proliferative activity of different prostatic lesions}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Anis_2023b, title = {Outbreak of severe myocarditis in England: havoc by a harmless virus}, author = {Heeba Anis and Akbar Basha Shaik and Angad Tiwari and Abel Alemayehu and Abubakar Nazir and Linda Atulinda and Magda Wojtara and Olivier Uwishema}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.1541}, doi = {10.1002/hsr2.1541}, issn = {2398-8835}, year = {2023}, date = {2023-08-31}, urldate = {2023-08-01}, journal = {Health Science Reports}, volume = {6}, issue = {9}, pages = {e1541}, publisher = {Wiley}, abstract = {Background: The World Health Organization (WHO) has been alerted to a concerning upsurge of severe myocarditis, an inflammatory heart condition, in neonates within Wales and South West England. The myocarditis cases are being intricately associated with enterovirus infection, belonging to the Picornaviridae family. The concerned pathogen poses a significant global disease burden, with an estimated 10 to 15 million symptomatic cases occurring annually in the United States alone. Neonates are particularly vulnerable with children under the age of one accounting for approximately 40% of enterovirus infections. Material and Methods: A comprehensive literature search was conducted using various databases including ClinicalTrials, Google Scholar, PubMed, ScienceDirect, MEDLINE, and Ovid Resources. The search strategy included utilizing keywords such as “myocarditis,” “Randomized controlled trials (RCTs). Only articles written in English were considered, and selection criteria included relevance to the research objectives, reasonable sample sizes, and robust methodology. In addition to the identified articles, meta-analyses, animal models and studies, and references from the selected articles were also examined to ensure a comprehensive review of the literature. Results: Ten hospitalized neonates, reported in the United Kingdom (UK), with positive PCR tests were reported to have myocarditis, predominantly caused by coxsackieviruses. The current situation in the region has brought global attention. With this study, we hope to draw attention to the critical aspects of the illness and, more crucially, the present strategies required to control the disease outbreak in England. Discussion: Current European Society of Cardiology (ESC) recommendations for the treatment of acute heart failure apply. Emerging research supports the use of immunosuppressive medication in some circumstances. Patients are advised to avoid aerobic activities for several months after healing. Neonatal enterovirus infections can vary in how they respond to IVIG therapy. The majority of enterovirus infections are self-limited, require no special therapy, and only little supportive care is required. Conclusion: The recent elevation in numbers for reported severe myocarditis in neonates within Wales and South West England, linked to enterovirus infection, poses a significant public health concern. Myocarditis caused by enteroviruses, particularly Group B coxsackieviruses, is associated with significant mortality rates. Diagnosis is supported by non-invasive techniques and cardiac enzyme blood tests. Treatment modalities primarily involve a palliative approach.}, key = {pmid37662542}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiddin_2023d, title = {Comparative analysis of cytological and molecular markers in breast lesions: a cross sectional study}, author = {Mohammed Ghouse Mohiddin and Mohammed Masooduddin and Habeebunnisa Tahniath and Rida Tariq}, url = {https://healthcare-bulletin.co.uk/article/comparative-analysis-of-cytological-and-molecular-markers-in-breast-lesions-a-cross-sectional-study-1068/}, doi = {10.5083/ejcm/2023}, issn = {2042-4884}, year = {2023}, date = {2023-08-29}, urldate = {2023-08-29}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {3}, pages = {1421-1425 }, abstract = {Background: Breast lesions are a significant global health concern, often requiring invasive procedures for definite diagnosis. Cytological and molecular markers present alternative, potentially less intrusive diagnostic methodologies. This study aims to compare the effectiveness of cytological and molecular markers for the diagnosis of breast lesions. Methods: A cross-sectional study was performed on a cohort of 500 patients presenting with breast lesions, undergoing cytological evaluation (Fine-Needle Aspiration Cytology) and molecular marker testing (HER2/neu, ER, PR, and Ki-67). Concordance between the two methods was evaluated. Results: Both cytological and molecular marker evaluations showed significant diagnostic potential. There was substantial concordance between the two modalities. However, molecular markers exhibited a slightly higher diagnostic sensitivity and specificity, especially in the detection of pre-malignant and malignant lesions. Conclusion: Cytological and molecular markers each offer valuable, complementary diagnostic approaches. While cytology provides rapid, cost-effective results, molecular markers offer increased sensitivity and specificity. Their combined usage can help minimize invasive procedures and improve patient outcomes. Further research is recommended to refine the usage of these diagnostic tools.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2023b, title = {Virovore: a breakthrough in virology}, author = {Qamar Sultana and Sumitaksha Banerjee and Vibhor Agrawal and Dattatreya Mukherjee and Ranjit Sah and Vikash Jaiswal}, url = {https://journals.sagepub.com/doi/10.1177/11786361231190333}, doi = {10.1177/11786361231190333}, issn = {1178-6361}, year = {2023}, date = {2023-08-21}, urldate = {2023-08-21}, journal = {Microbiology Insights}, volume = {16}, publisher = {SAGE Publications}, key = {pmid37621408}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2023b, title = {Diffusion restriction in bilateral thalami: beyond artery of percheron infarct}, author = {Sandhya Manorenj and Reshma Sultana Shaik and Sravan Kumar Marupaka and Tasneem Ara}, url = {https://journals.lww.com/neur/fulltext/2023/71040/diffusion_restriction_in_bilateral_thalami__beyond.22.aspx}, doi = {10.4103/0028-3886.383876}, issn = {0028-3886}, year = {2023}, date = {2023-08-18}, urldate = {2023-08-18}, journal = {Neurology India}, volume = {71}, issue = {4}, pages = {754-759}, publisher = {Medknow}, abstract = {Background: Bilateral thalamic infarction, especially the medial thalamus, has been characteristically described in the artery of Percheron (AOP) affection. However, bilateral thalamic restriction has been described in many entities beyond the AOP infarction. Objective: Here we describe a case series (three cases) with infection as an etiology for bilateral thalamic lesions in the topographic distribution of the AOP from a tertiary care center in tropical India. Materials and Methods: Case series during a 1-year period collecting cases with bilateral thalamic diffusion restriction on MRI who did not have thalamic infarcts and their outcomes. Results: Bilateral thalamic lesion can occur in both bacterial and viral infections such as tuberculosis, dengue, and SARS-COV-2. Thus, we intend to add infections as one of the etiologies in the ever-expanding list of conditions that produce bilateral thalamic restriction. Conclusions: All the acute symmetric thalamic lesions are not always secondary to vascular insult. Accurate assessment and prompt diagnosis can prevent unnecessary delays in treatment. To our knowledge, this is the first case series in the literature that throws light on the bilateral thalamic lesions in the topographic distribution of the AOP secondary to infections in a tropical country like India.}, key = {pmid37635510}, keywords = {General Medicine, Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2023, title = {A comprehensive review on neuroendocrine neoplasms: Presentation, pathophysiology and management}, author = {Qamar Sultana and Jill Kar and Amogh Verma and Shreya Sanghvi and Nirja Kaka and Neil Patel and Yashendra Sethi and Hitesh Chopra and Mohammad Amjad Kamal and Nigel H. Greig}, url = {https://www.mdpi.com/2077-0383/12/15/5138}, doi = {10.3390/jcm12155138}, issn = {2077-0383}, year = {2023}, date = {2023-08-05}, urldate = {2023-08-01}, journal = {Journal of Clinical Medicine}, volume = {12}, issue = {15}, pages = {5138}, publisher = {MDPI AG}, abstract = {Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with neuroendocrine differentiation that can arise from any organ. They account for 2% of all malignancies in the United States. A significant proportion of NEN patients experience endocrine imbalances consequent to increased amine or peptide hormone secretion, impacting their quality of life and prognosis. Over the last decade, pathologic categorization, diagnostic techniques and therapeutic choices for NENs—both well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs)—have appreciably evolved. Diagnosis of NEN mostly follows a suspicion from clinical features or incidental imaging findings. Hormonal or non-hormonal biomarkers (like serum serotonin, urine 5-HIAA, gastrin and VIP) and histology of a suspected NEN is, therefore, critical for both confirmation of the diagnosis and classification as an NET or NEC. Therapy for NENs has progressed recently based on a better molecular understanding, including the involvement of mTOR, VEGF and peptide receptor radionuclide therapy (PRRT), which add to the growing evidence supporting the possibility of treatment beyond complete resection. As the incidence of NENs is on the rise in the United States and several other countries, physicians are more likely to see these cases, and their better understanding may support earlier diagnosis and tailoring treatment to the patient. We have compiled clinically significant evidence for NENs, including relevant changes to clinical practice that have greatly updated our diagnostic and therapeutic approach for NEN patients.}, key = {pmid37568540}, keywords = {General Medicine, No Department}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2023, title = {A clinico-histopathological and etiological assessment of different cutaneous granulomatous lesions}, author = {Rubiya Khatoon and Venu Somanapally and Naushaba Tazeen}, url = {https://www.jcdronline.org/admin/Uploads/Files/64a958b5e136d9.71957212.pdf}, issn = {0975-3583}, year = {2023}, date = {2023-07-31}, urldate = {2023-07-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {14}, issue = {7}, pages = {446-449}, abstract = {Aim: This study was conducted with the aim to evaluate the frequency and patterns of different cutaneous granulomatous lesions with its clinico-histopathological correlation to reach etiological diagnosis. Materials and Methods: The present cross-sectional observational was conducted in the Department of Pathology, Mamata Academy of Medical Sciences, Hyderabad for the period of 1 year. This study enrolled 100 cases of skin biopsies after histopathological confirmation of granulomatous lesions. Results: 100 cases were studied in which male predominance was noted in 64 (64%) cases and females constituted 36 (36%) cases. Most of the patients were noted in age group of 21 to 31 years i.e 36 (36%) cases followed by 20 (20%) cases in 31 to 41years. 86% of cases were seen below 50 years of age in ourstudy. Leprosy remained the significant causative reason for infectious granulomatous dermatoses succeeded by tuberculosis of skin. Borderline tuberculoid leprosy was found to be predominant, constituting 24 (24%) cases followed by indeterminate type 22 (22%) cases and lepromatous leprosy 21 (21%) cases, tuberculoid leprosy 18 (18%) cases and 8 (8%) cases of borderline lepromatous leprosy.Lupus vulgaris constituted 2 cases (2%) and only 2 (2%) case of sarcoidosis was found. Conclusion: Leprosy was the most common cause of cutaneous granuloma followed by Tuberculosis,fungal infection and foreign body reaction. Among the cases of leprosy, borderline tuberculoid leprosy and tuberculoid leprosy were the commonest subtype. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2023, title = {Multisystem inflammatory syndrome in children (MIS-C) of Asian countries: a mini-literature review on its clinical characteristics and outcomes}, author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari}, url = {https://esmed.org/MRA/mra/article/view/4070}, doi = {10.18103/mra.v11i7.2.4070}, issn = {2375-1924}, year = {2023}, date = {2023-07-29}, urldate = {2023-07-29}, journal = {Medical Research Archives}, volume = {11}, issue = {7.2}, pages = {1-7}, abstract = {COVID-19 pandemic though has reached endemic levels in most of the countries, it has left an indelible mark on the healthcare systems across the world. One of the emerging challenges faced by physicians and researchers all around the world is the increased incidence of Multisystem inflammatory syndrome in children (MIS-C). Most of the research work conducted till date focusses on the pathophysiology, management and treatment of this syndrome. Multisystem inflammatory syndrome in children has been found to be a consequence of hyperactive immune system resulting from cytokine activation and release of immune complexes subsequent to COVID-19 infection. This condition is also associated with multisystem dysfunction which if not diagnosed early and not treated promptly, could result in an increased mortality among children. Most of the cases have been reported from European and American countries, but not many from Asia. This literature review provides for plausible reasons as to why the incidence of multisystem inflammatory syndrome in children has been less in Asian countries compared to the rest of the world. It also gives insights into the treatment protocols for multisystem inflammatory syndrome in children followed by hospitals in these countries and also highlights how different MIS-C is from Kawasaki disease in terms of clinical presentation since both these conditions share a common disease spectrum. This review also lists out the clinical features and treatment followed in such patients belonging to Asian countries.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Tajeen_2023, title = {Assessment of second-hand smoking among rural population: a prospective study}, author = {Saniya Tajeen and Mehaboobi Shaik and Hafsa Jabeen and Sayeedunnisa Sarah}, doi = {10.5083/ejcm/2023}, issn = {2042-4884}, year = {2023}, date = {2023-07-16}, urldate = {2023-07-16}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {3}, pages = {1149-1154}, abstract = {Background: Exposure to secondhand smoke has no safe limit. Secondhand smoking contributes to significant health problems in India. Apart from cancer, exposure to secondhand smoke has been reported to be associated with several respiratory diseases (including asthma, respiratory infections such as bronchitis and pneumonia, wheezing, coughing), ear infections, sudden infant death syndrome, and slow fetal growth and lung development. However, the overall rates for smoking, including consumption of different tobacco products, including smokeless tobacco, are still high. Smoking is a common practice among many adults in Indian people generally have very low concerns regarding the adverse health effects of secondhand smoking. This study aimed to determine the factors associated with exposure to secondhand smoke among subjects in households of rural India. Materials and methods: We used two measures of SHS: exposure to SHS at home and exposure to SHS in the workplace. SHS exposure at home is estimated for non-smokers who reported anyone smoking inside his/her home. Exposure to SHS in the workplace is estimated for non-smokers who reported anyone smoking in the workplace in the past 30days before the survey. Statistical techniques such as χ2 test, logistic regression and discriminant function analysis were used. Result: The prevalence of SHS exposure at home was 55.8%, where 13.3% of children lived with one smoker, while 50% of children lived with ≥2 smokers. There was a significant difference in the mean score of the combined cognitive tests between SHS-exposed and non-exposed children after adjustment for sex, parental educational level, family income and academic performance [Pillai’s Trace=0.084, F statistic (df)=6.803 (4302), p<0.001]. Conclusion: Current smoking and exposure to second-hand smoke among internal migrants in India is high. Socio-demographic characteristics and migration status were strongly associated with current smoking and second-hand smoke exposure. We recommend specifically targeted tobacco control interventions to help to address these risk factors, such as focusing on divorced/widowed women.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Gangannapalle_2023, title = {Nanoparticle albumin‑bound paclitaxel and solvent-based paclitaxel as chemotherapy options for patients with advanced gastric cancer: a systematic review and meta-analysis}, author = {Mahesh Gangannapalle and Husna Shahnoor and Lubna Sattar and Talwinder K. Nagi and Marwah Al-Tekreeti and Muhammad Waqas Khan and Madiha D. Haseeb and Areeba Khan}, url = {https://www.cureus.com/articles/168559-nanoparticle-albuminbound-paclitaxel-and-solvent-based-paclitaxel-as-chemotherapy-options-for-patients-with-advanced-gastric-cancer-a-systematic-review-and-meta-analysis#!/authors}, doi = {10.7759/cureus.41711}, issn = {2168-8184}, year = {2023}, date = {2023-07-11}, urldate = {2023-07-01}, journal = {Cureus}, volume = {15}, issue = {7}, pages = {e41711}, publisher = {Springer Science and Business Media LLC}, abstract = {The aim of this study is to assess and compare the effectiveness and safety of nanoparticle albumin-bound paclitaxel (nab-PTX) and solvent-based PTX (sb-PTX) as treatment options for advanced gastric cancer. This meta-analysis was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. We carried out a comprehensive search of PubMed, Google Scholar, and EMBASE from inception to June 15, 2023. The search strategy included the following keywords: "Nanoparticle albumin-bound paclitaxel," "solvent-based paclitaxel," and "advanced gastric cancer," along with their synonyms and medical subject heading (MeSH) terms. In this meta-analysis, the primary outcome was the comparison of overall survival and progression-free survival between the two groups. For safety purposes, we compared the risk of hematological and non-hematological events between the two groups. Four studies were included in this meta-analysis enrolling 1052 patients (483 received nb-PTX and 569 received sb-PTX). In terms of efficacy, nab-PTX showed favorable trends in overall survival and progression-free survival, despite no statistically significant differences being reported. The subgroup meta-analysis showed that nab-PTX seemed to have a better effect on peritoneal metastasis compared to sb-PTX. Regarding safety, the number of patients with neutropenia and leucopenia was significantly higher in the nab-PTX group compared to the sb-PTX group. However, the difference was statistically insignificant. Future research should focus on conducting more robust studies to further validate these findings and establish a stronger evidence base for the use of nab-PTX in this patient population.}, key = {pmid37575705}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2023, title = {In vitro isolation and characterization of multipotent postnatal stem cells from human dental pulp: an approach for regeneration of neural crest tissue}, author = {Nikhat Fatima and Aleem Ahmed Khan and Sandeep Kumar Vishwakarma}, url = {https://journals.lww.com/jpbs/fulltext/2023/15002/in_vitro_isolation_and_characterization_of.61.aspx}, doi = {10.4103/jpbs.jpbs_232_23}, issn = {0976-4879}, year = {2023}, date = {2023-07-11}, urldate = {2023-07-01}, journal = {Journal of Pharmacy and BioAllied Sciences}, volume = {15}, issue = {Suppl 2}, pages = {S1040-S1042}, publisher = {Medknow}, abstract = {Postnatal dental pulp tissues give the proper justification of the stem cell assimilation and characteristic of the multipotent of the stem cells. Researchers use an in vitro isolation process for clarifying the different stages of staining and cell division. Data collected from various sources helps in understanding how the stem cells help in tissue regeneration. It highlights the immunological phenotypes with the synthesis with cDNA for mentioning molecular immunology. Study also mentions the mitochondrial consistency to measure the potentiality regarding the immunology and the way it differs from 0 to 21 days. Researchers also mention the way for the future development by utilizing the key advantages and definite multipotent of the dental stem cells.}, key = {pmid37693979}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Khan_2023c, title = {Irritant contact dermatitis due to povidone-iodine following a surgical intervention: an unusual case report}, author = {Mohammed Affan Osman Khan and Rithika Ramadugu and Tarun Kumar Suvvari and Vijayalakshmi M. and Vimal Thomas}, url = {https://journals.sagepub.com/doi/epub/10.1177/2050313X231185620}, doi = {10.1177/2050313x231185620}, issn = {2050-313X}, year = {2023}, date = {2023-07-04}, urldate = {2023-01-01}, journal = {SAGE Open Medical Case Reports}, volume = {11}, publisher = {SAGE Publications}, abstract = {The most common day-to-day antiseptic preparation used before any surgery usually involves povidone-iodine. Any irritant reaction to it can be devastating for the patient’s aspect and would raise the need for a preliminary investigation prior to going through any antiseptic preparation. In literature, very few cases were reported on irritant dermatitis with povidone-iodine in Indian setting. We present a case of an 18-year-old female presented with irritant contact dermatitis due to povidone-iodine following a surgical intervention.}, key = {pmid37434898}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiddin_2023c, title = {Frozen section evaluation and clinicopathological correlation of sentinel lymph nodes in breast carcinoma}, author = {Mohammed Ghouse Mohiddin and Asiya Tabassum and Maryam Fatima and T. S. Shamshuddeen}, url = {https://www.makhillpublications.co/files/published-files/mak-rjms/2023/3-302-306.pdf}, doi = {10.59218/makrjms.2023.302.306}, issn = {1815-9346}, year = {2023}, date = {2023-07-03}, urldate = {2023-07-03}, journal = {Research Journal of Medical Sciences}, volume = {17}, issue = {3}, pages = {302-306}, abstract = {The evaluation of sentinel lymph nodes (SLNs) plays a crucial role in the management and prognosis of breast carcinoma. This study aimed to investigate the utility of frozen section evaluation in assessing SLNs and its clinicopathological correlation in breast carcinoma patients. A retrospective analysis was conducted on a cohort of breast carcinoma patients who underwent SLN biopsy and frozen section evaluation. The frozen sections were evaluated for the presence of metastatic deposits and the results were compared with the final histopathological examination of the SLNs. The utility of frozen section evaluation in assessing sentinel lymph nodes (SLNs) based on the final histopathology results. The table indicates a significant association between frozen section evaluation and final histopathology, highlighting the value of frozen section evaluation in assessing SLNs. The concordance between frozen section evaluation and the final histopathological examination of SLNs regarding the presence or absence of metastatic deposits. The significant association between frozen section evaluation and metastatic deposits suggests the reliability of frozen section evaluation in detecting metastasis in SLNs. The clinicopathological parameters associated with SLN involvement. The significant correlations observed between Tumor Size, Histological Grade, Hormone Receptor Status, Lymphovascular Invasion and SLN involvement emphasize the importance of these parameters in predicting SLN involvement in breast carcinoma patients. These findings contribute to clinical decision‐making and management strategies for patients with breast carcinoma. Frozen section evaluation of SLNs in breast carcinoma provides valuable intraoperative information for immediate decision‐making regarding axillary lymph node dissection. It demonstrates high accuracy in detecting metastatic involvement of SLNs. The clinicopathological correlation of frozen section results with various tumor characteristics helps in better understanding the disease progression and optimizing patient management. Further prospective studies are warranted to validate these findings and refine the clinical application of frozen section evaluation in breast carcinoma.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2023, title = {Self-directed learning: health care professional's perspective-a study}, author = {Munazza Fathima and Syeda Noorul Absar and Ghulam Subhani and Neeraj Sadiq and Mohammed Khaleel and Mohammed Mohsin and Madhipati Sai Krishna}, url = {http://ajms.alameenmedical.org/ArticlePDFs/6%20AJMS%20V16.N3.2023%20p%20216-222.pdf}, issn = {0974-1143}, year = {2023}, date = {2023-07-01}, urldate = {2023-07-01}, journal = {Al Ameen Journal of Medical Sciences}, volume = {16}, issue = {3}, pages = {216-222}, abstract = {Background: Self-directed learning is a teaching learning method emphasized as a part of newly developed competency based medical education (CBME) which was implemented in 2019 and since then it is an active part of the curriculum. Aims and Objectives: To evaluate the shift in learning process from teacher based education to a student based instruction by assessment of Self-Directed Learning Readiness (SDLR) scores among health professional’s medical students, nursing students, Physiotherapy and Pharmacy students. Material and Methods: A questionnaire based prospective observational study was done in Deccan College of Medical Sciences from Aug 2022 to October 2022. Statistical analysis was done using R language. Results: Maximum SDLR score obtained was 105 and minimum was 21. Scores <80 were considered low and > 80 as high. SDLR scores of most students were low. The scores were comparable to other studies like a South Indian study done who reported a mean SDLRS score in the low readiness category and some studies scores were high readiness to learn. Conclusion: Most students are ready for self- directed learning but their scores need to improve.}, keywords = {Community Medicine, Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Nidha_Fatima_2023, title = {A case report of Kocher Debre Semelaigne syndrome – congenital hypothyroidism with pseudomuscular hypertrophy}, author = {Nidha Fatima and Faraaz Adil and Habib Khan Gulab Khan Pathan}, url = {https://mansapublishers.com/index.php/ijch/article/view/3956/3281}, doi = {10.32677/ijch.v10i7.3956}, issn = {2349-6118}, year = {2023}, date = {2023-07-01}, urldate = {2023-07-01}, journal = {Indian Journal of Child Health}, volume = {10}, issue = {7}, pages = {90-91}, publisher = {Mansa STM Publishers}, abstract = {Kocher Debre Semealaigne Syndrome (KDSS) is a rare condition with the manifestation of hypothyroidism associated with pseudomuscular hypertrophy. This syndrome is rare in countries with screening programs for hypothyroidism at birth. We are reporting a rare case of KDSS in which earlier diagnosis and treatment would result in the reversal of many symptoms. The main objective of presenting this case is to enlighten pediatricians about prompt diagnosis and timely management to prevent avoidable complications.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Bari_2023b, title = {Functional and radiological outcome by various modalities of surgical fixation of proximal humerus fracture}, author = {Mohammed Abdul Bari and Mohammed Hassan Rafeeq and Bandela Venugopal and Mohmad Irfan Nagnur}, url = {http://jcdronline.org/index.php/JCDR/article/view/7947}, issn = {0975-3583}, year = {2023}, date = {2023-06-30}, urldate = {2023-06-30}, journal = {Journal of Cardiovascular Disease Research}, volume = {14}, issue = {6}, pages = {1122-1129}, abstract = {In this study, we wanted to test the efficacy and functional outcome of locking compression plate in proximal humerus fractures, evaluate the incidence of complication that may occur with locking compression plate in proximal humerus fractures, study different modalities of fixations in proximal humerus fractures, and assess and compare the functional outcome. Material and Methods: This was a hospital based observational study conducted among 20 patients who were diagnosed with proximal humerus fracture attending the Department of Orthopaedics, Deccan College of Medical Sciences, Tertiary Care Centre, Hyderabad, from October 2018 to August 2019 after obtaining clearance from the institutional ethics committee and written informed consent from the study participants. Results: ORIF with LCP (35%) was the most common modality of treatment. Percutaneous pinning was done in 20% of the patients. 15% of them had CRIF with IM nails. ORIF with k wires and ORIF with k wires and cancellous wires were done in 10% of patients each. Shoulder hemiarthroplasty and ORIF with Ethibond suture were done in 5% of patients each. 55% of the patients developed complications in the post-operative period in the form of infections and stiffness. Of the twenty patients, four (20%) had excellent results, thirteen patients (65%) had satisfactory results, one (5%) had unsatisfactory results and one (5%) was a failure. Conclusion: Proximal humerus fractures are more common in 30-39 years and 40-49 years. It is more common in females. The most common cause is RTA. 2-part fracture is most common. ORIF with LCP was the most common modality of treatment. About half the patients had complications in the form of infections and stiffness.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Jindal_2023, title = {Scoring system for the use of nebulizers in the primary care settings: an expert consensus statement}, author = {Surinder K. Jindal and Shrikant Pawar and Ashfaq Hasan and Aloke Ghoshal and Raja Dhar and Subodh K. Katiyar and K. S. Satish and Deepak Talwar and Sundeep Salvi}, url = {https://pubmed.ncbi.nlm.nih.gov/37355847/}, doi = {10.5005/japi-11001-0273 }, issn = {0004-5772}, year = {2023}, date = {2023-06-30}, urldate = {2023-06-30}, journal = {Journal of the Association of Physicians of India}, volume = {71}, issue = {6}, pages = {11-12}, abstract = {Background: The use of nebulizers is an important and useful method for delivering drugs to the lungs in patients with various airway and lung parenchymal disorders. They are primarily used in patients with acute symptoms and in a selected group of patients for maintenance treatment.Its use has increased, especially during the coronavirus disease 2019 (COVID-19) pandemic. To ensure the appropriate use of nebulizers by primary care physicians and to guide them, we aimed to develop a simple nebulizer use score.Methods: An expert working group (EWG) of pulmonologists were formed who using a semi-Delphi method, developed a list of variables and a cut-off score to decide when to use nebulizers. We started with a total of 55 variables that were developed through an exhaustive review of the literature. These were further reduced to smaller numbers that had the maximum score as well as concordance with the EWG. The scores ranged from 1 to 10 (completely disagree to completely agree), and only those above 7.5 were selected.Results: A total of 8 variables with the highest scores were selected (Table 1), which had a total maximum score of 40. A score of <15 was suggested to indicate no use of nebulizer and >20 to suggest definite use of nebulizer. A score between 15 and 20 was suggested for physician judgment.A separate table of 12 conditions was made where the use of nebulizers was mandatory.Conclusion: This first-of-its-kind nebulizer score can be used by primary care physicians to decide which patients should be put on nebulizer treatment.}, key = {pmid37355847}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Soora_2023, title = {Comparing cervical length measured by transvaginal ultrasound with Bishop score for predicting successful labor induction}, author = {Shubhangi Soora and Kanchan and Beeravolu Mounika Reddy and Shradha Jain}, url = {http://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue6,Article70.pdf}, issn = {0975-1556}, year = {2023}, date = {2023-06-30}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {15}, issue = {6}, pages = {522-527}, abstract = {Background: Labour induction is one of the most common obstetric interventions. The baby should be born naturally, as it would be the optimum situation. We have a wide range of tools at our disposal that can help us successfully induce labour. The current study sought to ascertain whether transvaginal ultrasound, which assesses cervical length, might predict labour induction outcomes more accurately than clinical evaluation as determined by the Bishop score. Methods: A total of 100 eligible women participated and underwent cervical assessment using transvaginal ultrasound and Bishop score. Labor induction followed the hospital’s standard protocol, including the use of Dinoprostone gel. Up to three doses of the gel were administered intracervically at 6-hour intervals if necessary. The progress of labor, time from induction to delivery, and mode of delivery were recorded. Results: This study found that approximately 65% of primi singleton pregnancies undergoing induction of labor with dinoprostone gel resulted in successful vaginal delivery within 24 hours. The transvaginal cervical length showed better predictive value than the Bishop score for delivery within 24 hours (p=0.001). While the Bishop score had higher sensitivity, the transvaginal cervical length had higher specificity and positive predictive value. Both cervical length and Bishop score were significant predictors of successful induction of labor (p=0.01). Conclusion: According to the study, there is a substantial correlation between both transvaginal sonography measures and the time from induction until delivery. Within 24 hours of induction, transvaginal cervical length assessment offers the highest sensitivity for predicting vaginal births.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Nasirabadi_2023, title = {Somatic symptoms disorder}, author = {Minhajzafar Nasirabadi}, url = {https://www.tjima.org/journal/index.php/tjima/article/view/105/161}, year = {2023}, date = {2023-06-28}, urldate = {2023-06-28}, journal = {Telangana Journal of IMA}, volume = {3}, issue = {1}, pages = {1-2}, abstract = {We Indians are not trained to express our emotions. We don’t speak when we suffer from emotional or psycho-logical disturbances. This repression of emotions or psychological disturbances are expressed in physical form. Thus many times psychological disorders mask themselves underneath physical complaints. }, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Khan_2023, title = {Effect of COVID-19 infection on mental health of medical students}, author = {Ariyan Khan and Mustafa Kagalwala and Minhajzafar Nasirabadi and Mazher Ali and Mehnaaz Sameera Arifuddin}, url = {https://www.tjima.org/journal/index.php/tjima/article/view/110}, doi = {10.52314/tjima.2023.v3i1.110}, year = {2023}, date = {2023-06-28}, journal = {Telangana Journal of IMA}, volume = {3}, issue = {1}, pages = {13–21}, abstract = {Background: Stressful environment in medical school often has a negative effect on students’ psychosocial well‐being and COVID-19 has a further additive effect on it. The COVID-19 pandemic is found to affect the mental health of the population. Undergraduate medical students are especially prone to mental health disorders and hence could be more vulnerable to the impact of the pandemic. An in‐depth understanding of how medical students experience psychological distress and coping is necessary for prospective students. Aim and Objective: To determine the effect of COVID-19 on mental health of medical students. Methods: A web-based cross-sectional study was carried out on 299 undergraduate medical students in the medical colleges of Telangana and Andhra Pradesh, India. They were divided into 4 groups based on whether the participants, their family members, both or none of them were affected with COVID-19 infection. The questionnaires provided to the participants in this study consisted of three components – (i) the demographic information that required participants to provide their gender, age and year of study (ii) COVID-19 related questionnaire and (iii) Depression, Anxiety, and Stress Scale‐42 (DASS-42) items to measure the levels of psychological distress among participants. Chi square statistical test and One-way analysis of variance (ANOVA) were the statistical tools used in this study. Results: It was observed that depression (χ=9.839, p=0.043) was found to be significant in participants who were not affected with COVID-19 infection. Statistically significant differences were observed in participants’ depression (χ=11.976, p=0.018) and stress (χ=9.839, p=0.043) levels whose family members were affected with COVID-19. One way ANOVA showed that anxiety levels (F(3,295)=4.267, p=0.006) was significantly higher when both participants and their family members (group 3) were affected with COVID-19 infection. Conclusion: This study has shown that COVID-19 pandemic and subsequent lockdowns affected the mental health of young population.}, keywords = {Physiology, Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Bari_2023, title = {Study of evaluation of functional outcome of compound fractures of tibia treated surgically by unreamed interlocking nail in adult patients}, author = {Mohammed Abdul Bari and Mohammed Akram and Bandela Venugopal and Mohmad Irfan Nagnur}, url = {https://www.healthcare-bulletin.co.uk/article/volume-13-issue-2-pages1504-1521-ra/}, issn = {2042-4884}, year = {2023}, date = {2023-06-21}, urldate = {2023-06-21}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {2}, pages = {1504-1521}, abstract = {Background and Objectives: Intramedullary interlocking nailing is currently considered the treatment of choice foropen(grade 1 and grade 2)tibial shaft fractures, with high rates of fracture union, advantages of early stabilization which decreases the morbidity and mortality rates in patients, allows early mobilization, reduces the incidence of infection,malunion,nonunion, or implant failure. This study is done to assess compound diaphyseal fractures of tibia and to evaluate the functional outcome of patients with open tibial shaft fracture treated with locked intramedullary nailing without reaming. Methods: Twenty adult patients of both sexes presented with open tibial shaft fractures to Princess Esra Hospital, Deccan College of medical sciences,Hyderabad who satisfies our inclusion criteria and are surgically fit are included in this study. All enrolled Patients were admitted from March 2020 to December 2021 were treated surgically with locked intramedullary interlocking nailing tibia without reaming and evaluated. Final assessment of functional outcome is done using JOHNER and WRUH’S Criteria. Results: The results of interlocking nail for fracture tibia without reaming were excellent in 15 patients (75%), good in 3 patients (15%) and fair in 2 patients (10%). The average healing time was 20.13 weeks. In our study valgus deformity of 3 degrees (3 patients) and varus deformity of 3 degrees (1 patient) is seen. There were 1 superficial infection (5%), 2 patients with anterior knee pain (10%), 1 patient with delayed union (5%) and 1 patient with shortening of 1cm seen (5%). Conclusion: The method of treatment employing closed intramedullary interlocking nailing without reaming to stabilize open (type 1 and type 2) diaphyseal fractures of tibia is ideal because of its excellent and good results. The method has a long learning curve but with the excellent results. The advantages of rapid rehabilitation and relatively few complications serve to recommend it for wider use.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Nasreen_2023, title = {Seroprevalence of HPV infection and its association with HPV vaccination in adolescent girls in suburbs of Hyderabad}, author = {Humera Nasreen and Habib Khan Gulab Khan Pathan and Sarfaraz Ahmed Manzoor Ahmed}, url = {https://healthcare-bulletin.co.uk/article/volume-13-issue-2-pages1436-1439-ra/}, doi = {10.5083/ejcm }, issn = {2042-4884}, year = {2023}, date = {2023-06-16}, urldate = {2023-06-16}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {2}, pages = {1436-1439}, abstract = {Background: The prevalence of cervical cancer is increasing day by day. One of the best methods to prevent it is vaccination by HPV (Human Papilloma Virus) vaccine. Now a day’s more and more females are coming forward to take HPV vaccine. Sero-prevalence is one of the best methods to assess disease burden in the community Objectives: 1. To study sero-prevalence of HPV in adolescent girls. 2. To study association of seroprevalence of HPV with HPV vaccination. Method: A community based cross sectional study was performed to assess the sero-prevalence of HPV at two private schools in suburban areas of Hyderabad, Telangana, in April 2022 to September 2022. Blood samples from 100 adolescent girls were collected & analysed for HPV specific antibodies by ELISA. Results: The sero-prevalence for HPV in the study group was low. There was a statistically significant HPV sero-positivity in all girls receiving HPV (<0.05). An association of sero-prevalence with age was analysed. There was no statistically significant association between age & HPV antibodies (p>0.05 Conclusion: The prevalence of HPV infection among adolescent girls is low and it is strongly associated with HPV vaccination.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Alla_2023, title = {Clinical outcome of established diagnostic and treatment modalities of COVID-19 associated myocarditis: a systematic review}, author = {Sai Santhosha Mrudula Alla and Pahel Agarwal and Roopeessh Vempati and Deekshitha Alla and Kavya Balusu and Suha Tarannum and Krish Patel and Sanjana Devaragudi and Devkumar Patel and Qamar Sultana and Kusum Paudel}, url = {https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2023/07000/clinical_outcome_of_established_diagnostic_and.48.aspx}, doi = {10.1097/ms9.0000000000000964}, issn = {2049-0801}, year = {2023}, date = {2023-06-16}, urldate = {2023-06-16}, journal = {Annals of Medicine & Surgery}, volume = {85}, issue = {7}, pages = {3583-3594}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, abstract = {Background: Despite the significant research and development of COVID-19 diagnostic and therapeutic approaches, the virus still poses a concern, particularly to groups that are already vulnerable. Several individuals experienced cardiac problems like myocardial infarction, arrhythmia, heart failure, cardiomyopathy, myocarditis, and pericarditis after they had recovered from the infection. Early diagnosis and timely management of sequelae are part of the therapy. However, there are gaps in the knowledge of the diagnostic and definitive treatment options for COVID-19 myocarditis. This review focuses on myocarditis associated with COVID-19. Objective: This systemic review provides the most recent overview of myocarditis caused by COVID-19, including clinical manifestations, diagnostic techniques, available treatments, and outcomes. Methods: The PubMed, Google Scholar, and ScienceDirect servers were used to conduct a systematic search in compliance with the PRISMA guidelines. Boolean search terms included “(COVID-19)” OR “(COVID19)” OR “(COVID-19 VIRUS INFECTION)” AND “(MYOCARDITIS)”. The results were tabulated and analyzed. Results: A total of 32 studies, including 26 case reports and 6 case series, were included in the final analysis, and 38 cases of COVID-19-associated myocarditis were analyzed. Middle-aged men constituted the most affected population (60.52%). Dyspnoea (63.15%), chest pain or discomfort (44.73%), and fever (42.10%) were the prevalent presentations. ST-segment abnormalities were reported in 48.38% of cases on electrocardiography testing. Leucocytic infiltration (60%) was the frequent finding obtained on endomyocardial biopsy. Cardiac magnetic resonance imaging yielded myocardial oedema (63.63%), and late gadolinium enhancement (54.54%) as the most common findings. Reduced ejection fraction (75%) was the frequent result obtained on echocardiography. Corticosteroids (76.31%) and immunomodulators (42.10%) were the well-established in-hospital medications. Veno-arterial extracorporeal membrane oxygenation (35%) was the most common intervention used to support the treatment. The frequent in-hospital complications were cardiogenic shock (30.76%), followed by pneumonia (23.07%). The mortality rate was 7.9%. Conclusion: Early detection and timely management of myocarditis are essential to reduce the risk of developing further complications. It is crucial to emphasize the need to evaluate COVID-19 as a possible cause of myocarditis in populations that are young and healthy to avoid fatal consequences.}, key = {pmid37427189}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2023, title = {Grace face sign in generalized myasthenia gravis (MG)}, author = {Reshma Sultana Shaik and Sandhya Manorenj}, url = {https://www.neurologyindia.com/temp/ni713606-2077886_054618.pdf}, doi = {10.4103/0028-3886.378674}, issn = {0028-3886}, year = {2023}, date = {2023-06-15}, urldate = {2023-06-15}, journal = {Neurology India}, volume = {71}, issue = {3}, pages = {606}, publisher = {Medknow}, key = {pmid37322783}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Pasham_2023, title = {Faradic stimulation in the treatment of functional aphonia: a case series}, author = {Navya Pasham and Khan Mohammed Zeeshan Ali and Arifuddin Ahmed and Arman Mehrukh and Minhajzafar Nasirabadi}, url = {https://journals.lww.com/tjpy/fulltext/2023/09010/faradic_stimulation_in_the_treatment_of_functional.16.aspx}, doi = {10.4103/tjp.tjp_26_23}, issn = {2455-8559}, year = {2023}, date = {2023-06-10}, urldate = {2023-06-10}, journal = {Telangana Journal of Psychiatry}, volume = {9}, issue = {1}, pages = {72-75}, publisher = {Medknow}, abstract = {Dissociative disorders have many clinical presentations, one of which is mutism. Hysterical mutism, or functional aphonia (FA), is a functional disorder of the vocal cords presenting as loss of voice with no change in the integrity of the anatomy or physiology of the voice box. Modern understanding of its etiology suggests a strong role for psychosocial stressors. Treatment modalities for this condition are aplenty and vary in mode of administration. This case series describes the use of faradic stimulation in the treatment of FA.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Jain_2023, title = {A comparative study of the impact of acute febrile illness during pregnancy}, author = {Shradha Jain and Shubhangi Soora and Kanchan and Beeravolu Mounika Reddy}, url = {http://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue5,Article175.pdf}, issn = {0975-1556}, year = {2023}, date = {2023-05-31}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {15}, issue = {5}, pages = {1373-1378}, abstract = {Introduction: Fever during pregnancy causes significant maternal and foetal complications. The coexistence of pregnancy may aggravate the risk to maternal life. The most common antenatal complications observed were preterm labour, premature rupture of membranes, oligohydramnios and intrauterine growth restriction. Material & Methods: Total 160 pregnant women more than 20 weeks of gestation were enrolled in which 80 were acute febrile (fever less than 7 days) and another 80 were afebrile subjects. Patient history, antenatal, Intra-natal, Postnatal and Foetal outcome complications were identified and monitored. Results: 78.75% had fever in the third trimester. 36.25% of febrile and 20% of non-febrile patients experienced premature labour. 36.25% babies born to febrile moms and 10 % from afebrile mothers required NICU admission. Conclusion: If the cause of the fever is identified and treated appropriately, the maternal and foetal problems may be prevented.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2023b, title = {Rare presentation of vagal paraganglioma in an early age: a case report and literature review}, author = {Asma Fatima and G. Raghavendra Prasad and Shaik Zahid Ali and Syed Faqeer Hussain Bokhari and Syed Abul Qasim Hussain Abedi and Ricardo Souza Júnior}, url = {https://pdf.sciencedirectassets.com/280165/1-s2.0-S2210261223X00066/1-s2.0-S2210261223004911/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEC8aCXVzLWVhc3QtMSJHMEUCIQDBGpUAAJD3f4cMWDSpTP9KNAmfiqJuoA2VkMv1kpifewIgaoAtoaMe7gNW2h2TLLww7V723OfVF44AfhsXxfcRqkkqsgUIKBAFGgwwNTkwMDM1NDY4NjUiDObQAAbK97IuiuD3miqPBYbr69qJ5oidw3icepSWPNNF4yqMwaOeUk6pf2JnKuCVM%2B2AqyaL1w63PMLM93qX7pK1lV%2BA8GPVlnP6vlSoXwkCDN4Nvpr2tqZbMn6BMAVLjYgROzQSheLwupsztBH1qeYvixkfMw%2BTSxE8o33pVxAHz6UTeT4RoO%2BBnSgDzO6jpdvemOm9HAn9Rmg2TtDvH3%2FqPvt6UkYy7z1VBCluhaoqeBjLoczsZ9f9Xr%2FrckqH5p1mL7pLaG%2FNNbIY16u9dAiBCXnv3jdZXwSyELCTdQlmcf%2BuzDija9wmpFvQ8Kd7iWPJ2PDV%2FelnKEfrbRKOkQI6jLZmPG5JjpYd%2FmvfMiU5LDGwAfvpIoUgbykG2V2cIEMXS%2FD1Dh0KmC2qEzrt6U8mEN6iwEsYlq%2B2qumXbRrzrenm4z0BOvZ4CVo%2FPpf8x3UNZ%2BESOJSlC6XlHwmv236oCY1oDW0DVMecwOYQ3QMgGW9sXZo6bBRoutMBF92kmzlFnvIW9RA%2FvzWx%2FrwQdYAJ8kA0jkjtVRkfF66cYv55vgZTcWFdrMOzHbjVjOgUbmcEyccgMQjGxSrTZi8hxqYbeTwvlNgnEneA86Os7l7S02s%2FiWWAtnNCk6Iwf37078%2Bs4tVTl1p7CCDYfsNARgJGszsnaMCJjUc9Xjt5puBA5qvRhY8HIwUlaEiQ2giSG9Pu3gzLxv9JYqAo9HdtU5Z8yw4Eq5gezpfAJ5i47fpI0zpsX1Fhm8xPpAeDdLpzNQJFa%2FtqBYmNxGMhizrCjKAoLfkP6w0JLzOfgGf8bNEihnioVgtxZdE3vVjXtHpamngRAvhnR%2F1l5vTyulq2sr0%2B4bc1zEdfwa5gVwyQMTXEcYb3hnPBaguTpmydgxgwwJm6qAY6sQEZFVpUp4ow8UY9TWysO9tIPa2h7AgOp%2BGRJMK%2BQ83L8lEHhpGGyeap8ydxQTxgjSG1%2BeN9VDRf8HAtR0OzV%2BR2MwTLz5V2Wn3xaM4i4dUxCrerMOC9P2fuGcO5exrX5Wujsv%2B8%2Bk0%2BKeJKJhIkl9%2Bus9OIwz4XAMilWgHDdY%2Ba2yA2p4qRv0h%2FHAxmMIm57vDRXDBpe30aRTccT8Fd%2B0%2BJmbpsK%2F1umKB7hDiUH4lr0DU%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20230923T073437Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYQNTLULHS%2F20230923%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=5cf2ce751a3f530d41d876d5adc18b4524aedeb75bf0ccb2c500677a57832012&hash=4f124584f3bb971c35e6edd96d2a338341f63587e5dd785f792c5ea486738432&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2210261223004911&tid=spdf-97b6fb85-7d4b-4620-a09e-da76325953a4&sid=d3a802bb9c9bc24c5d8ab168346de759acb2gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d5750015654015753&rr=80b11b32889d2e87&cc=in}, doi = {10.1016/j.ijscr.2023.108362}, issn = {2210-2612}, year = {2023}, date = {2023-05-27}, urldate = {2023-05-27}, journal = {International Journal of Surgery Case Reports}, volume = {107}, pages = {108362}, publisher = {Elsevier BV}, abstract = {Introduction and importance: Vagal paragangliomas of neck are rare tumours of neural crest origin usually arising in elderly age with female predominance. They have a vague clinical presentation therefore difficult to diagnose preoperatively. We hope that this case report and literature review would add to the existing literature and help devise a comprehensive diagnostic and therapeutic plan for vagal paragangliomas. Case presentation: We report a case of vagal paraganglioma occurring in a 13-year-old male which is an extremely rare presentation in this age group. The patient presented with a large solitary painless progressively growing mass in posterior triangle of neck. External jugular vein was stretched and trachea was deviated medially. The mass was arising via a twig from vagus nerve and was surgically excised. Diagnosis was established post-operatively through histopathological analysis. Clinical discussion: Vagal paraganglioma is a rare occurrence in male teenagers and may mimic schwannoma, neuroma, jugular meningioma, or other gangliomas. Surgical excision is mainstay of treatment but resultant vagal complications and neurological consequences are usually unavoidable. Nonetheless, the prognosis may be easily improved with sound surgical judgement, skill, and routine follow-up. Conclusions: Vagal paraganglioma usually presents as a swelling in neck and cannot be diagnosed on simple clinical examination. CT scan and MRI are imaging modalities of choice and can be coupled with angiography to increase diagnostic accuracy. Although both radiation therapy and surgical excision have both been found to be successful treatment options, it is still unclear which is more beneficial.}, keywords = {General Surgery, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Degani_Costa_2023, title = {Vaping and hookah use among medical trainees: a multinational survey study}, author = {Luiza Helena Degani-Costa and Fernanda Gushken and Claudia Szlejf and João Roberto Resende Fernandes and Thiago M. Fidalgo and Luiza Helena Degani-Costa and Fernando Pereira Bruno and Ana B Tokeshi and Christian Douradinho and Paulo César Rodrigues Pinto Corrêa and Antonio Carlos Aguiar Brandão and Vilson Geraldo Campos and Lara Gandolfo and Oscar César Pires and Ramon Andrade Bezerra De Mello and Marli Maria Knorst and Carlos Leonardo Carvalho Pessôa and Ricardo Golmia and Guilherme Borges Gomes Silva and Karine Corcione Turke Antônio and Carlos Palandri Chagas Carla and Janice Baister Lantieri and Yasmin Paz De Marchi and Daniel Lacerda Heringer and Bruna Granig Valente and Larissa Moreira David and Carolina Lacerda Souza and Juliana Monteiro Ramos and Rafael Moura Almeida and Thainá Mendonça Bentes and Vinicius Ryu Kami and Giancarlo Lucchetti and Marina Toscano Silveira and Arthur Somavila Barros and Vicente Bigolin Hauli and Luis Fernando Silva Bouzas and Antonia Worcman Carvalho and Juliana Moreira Guerra and Gabriel Lima Benchimol and Lincoln Basílio Alves and Victória Mourão Luz and Caroline Meneses Resende and Antonio Andrei Silva Sena and Ana Karoline Mendes Sales and Gabriel Victor Silva Pereira and Aditi Mohta and Pentapati S. S. Kumar and Limalemla Jamir and Kandipudi K. L. Prasad and Devi Madhavi Bhimarasetty and Makineedi Rama Lakshmi and Rajesh Neeluri and Mahesh V. and Pradnya V. Shinde and Radha Ramani Bonu and Chithra Boovaragasamy and Gnanamani Gnanasabai and Simmi Oberoi and Aman Dev Singh and Tumul Nandan and Fernando Pereira Bruno and Yasmin F. Tehrani and Daniel Kaufman and Cameron Ghassemi and Matthew G. K. Benesch and Morag G. Ryan and Jonathan P. Fuld and Hardeep Lotay}, url = {https://www.ajpmonline.org/article/S0749-3797(23)00231-3/fulltext#%20}, doi = {10.1016/j.amepre.2023.05.009}, issn = {0749-3797}, year = {2023}, date = {2023-05-10}, urldate = {2023-05-01}, journal = {American Journal of Preventive Medicine}, publisher = {Elsevier BV}, abstract = {The increased use of E-cigarettes and hookah among young consumers represents a public health concern. This study aimed to investigate the frequency and patterns of use of E-cigarettes and hookah among medical trainees. This cross-sectional multinational online survey included medical students, residents, and fellows in Brazil, the U.S., and India between October 2020 and November 2021. Information on sociodemographics; mental health; and E-cigarettes, hookah, tobacco, marijuana, and alcohol use were collected. Generalized structural equation models were used in 2022 to explore the factors associated with current vaping and current hookah use (ongoing monthly/weekly/daily use). People reporting previous sporadic/frequent use or those who never used/only tried it once were the reference group. Overall, 7,526 participants were recruited (Brazil=3,093; U.S.=3,067; India=1,366). The frequency of current vaping was 20% (Brazil), 11% (U.S.), and <1% (India), and current hookah use was 10% (Brazil), 6% (U.S.), and 1% (India). Higher family income (OR=6.35, 95% CI=4.42, 9.12), smoking cigarettes (OR=5.88, 95% CI=4.88, 7.09) and marijuana (OR=2.8, 95% CI=2.35, 3.34), and binge drinking (OR=3.03, 95% CI=2.56, 3.59) were associated with current vaping. The same was true for hookah use: higher family income (OR=2.69, 95% CI=1.75, 4.14), smoking cigarettes (OR=3.20, 95% CI=2.53, 4.06), smoking marijuana (OR=4.17, 95% CI=3.35, 4.19), and binge drinking (OR=2.42, 95% CI=1.96, 2.99). In conclusion, E-cigarettes and hookah were frequently used by Brazilian and American trainees, sharply contrasting with data from India. Cultural aspects and public health policies may explain the differences among countries. Addressing the problems of hookah and E-cigarette smoking in this population is relevant to avoid the renormalization of smoking.}, key = {pmid37178979}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Karan_2023, title = {Recurrent episcleritis-a rare presentation of mixed connective tissue disease}, author = {Siddharth Karan and Arshia Mohammed and Sana Fatima}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/recurrent-episcleritis--a-rare-presentation-of-mixed-connective-tissue-disease_April_2023_0614198974_5613429.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2023}, date = {2023-04-30}, urldate = {2023-04-30}, journal = {International Journal of Scientific Research}, volume = {12}, issue = {4}, pages = {51-52}, abstract = {Episcleritis refers to inflammation of the loose connective tissue between the sclera and the conjunctiva. The majority of episcleritis cases are idiopathic, but 26% to 36% of patients have an associated systemic disorder that is responsible for the pathological process and development of episcleritis. It is also well established that the incidence and prevalence of episcleritis are higher in populations with systemic collagen-vascular disease and autoimmune diseases. However recurrent episcleritis in Mixed Connective Tissue Disease has not been reported before in literature. Here we are reporting a case of recurrent bilateral nodular episcleritis as a rare presentation of MCTD.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2023c, title = {A comparative study of effect of position (sitting versus lateral decubitus) during spinal anaesthesia on the incidence of postdural puncture headache in patients undergoing lower limb orthopaedic surgeries}, author = {Vijaya Rekha Koti and Heena Naaz}, url = {https://www.academicmed.org/Uploads/Volume5Issue3/57.%20[580.%20JAMP_MEDP]%20264-268.pdf}, issn = {2687-5365}, year = {2023}, date = {2023-04-30}, urldate = {2023-04-30}, journal = {International Journal of Academic Medicine and Pharmacy }, volume = {5}, issue = {3}, pages = {264-268}, abstract = {Background: The most common method of anesthesia for Lower limb surgeries is spinal anesthesia, and postdural puncture headache (PDPH) remains a major complication of this procedure. Nowadays, postdural puncture headache is a major cause of morbidity in patients undergoing surgeries under spinal anesthesia. This headache is the most popular reason for claims against anesthesiologists. The position after spinal anesthesia has been evaluated as a contributory factor in the occurrence of postdural puncture headache, but the position before spinal anesthesia has not been evaluated much. Aim: To compare the incidence of Post-Dural Puncture Headache following spinal anaesthesia in lateral decubitus position and sitting position in patients who underwent lower limb surgeries under spinal anaesthesia. Patients and Methods: This study is performed in Owaisi group of hospitals in 100 patients between the age 19 yrs and 35yrs undergoing lower limb surgeries. The intensity of post-dural puncture headache was assessed postoperatively using a Visual Analogue Scale (VAS) immediately on postoperative day (POD) one to POD 5. VAS is 10 point numeric scale with 0 considered as no pain and 10 considered as severe pain ever experienced. Results: The incidence of post dural headache is more in the sitting group compared to that of lateral decubitus position.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2023b, title = {A peccant tale of an innocent investigation- unmasking of asymptomatic idiopathic intracranial hypertension (IIH)}, author = {Reshma Sultana Shaik and Sandhya Manorenj and Sravan Kumar Marupaka and S. Chandra Reddy}, url = {https://www.neurologyindia.com/temp/ni712338-1753714_045217.pdf}, doi = {10.4103/0028-3886.375426}, issn = {0028-3886}, year = {2023}, date = {2023-04-29}, urldate = {2023-04-29}, journal = {Neurology India}, volume = {71}, issue = {2}, pages = {338-339}, publisher = {Medknow}, key = {pmid37148067}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Arif_2023, title = {Two cases of seizures due to lignocaine toxicity following elective circumcision}, author = {Ahlaam Arif and Mohammed Mujahid Ali and Shaik Mazahar Hussain and Habib Khan Gulab Khan Pathan and Shalini Akunuri}, url = {https://irispublishers.com/ann/pdf/ANN.MS.ID.000855.pdf}, doi = {10.33552/ANN.2023.15.000855}, issn = {2641-1911}, year = {2023}, date = {2023-04-21}, urldate = {2023-04-21}, journal = {Archives in Neurology & Neuroscience}, volume = {15}, issue = {2}, pages = {1-2}, abstract = {Lignocaine is the most preferred local anesthetic worldwide; however, it is not without its side effects. Local anesthetic systemic toxicity is commonly reported as seizures, respiratory arrest, or adverse cardiac events like arrythmias. We report 2 cases of lignocaine toxicity presenting as generalized seizures and respiratory failure. Both required mechanical ventilation for variable duration, and both were eventually discharged, however, in stark contrasting state where one of them was completely normal and the other severely neuro-debilitated. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{VR_2023, title = {A case of megaspleen with micrographism}, author = {Subrahmanyan V. R. and Deepu V. Joy and Sweta Sahu and Anagha S. K. and Abhishek L. N. U. and Vempati Roopeessh and Prerna Chandra and Vishal Venugopal and Sourav Bansal and Rishman Tandi}, url = {https://www.cureus.com/articles/114955-a-case-of-megaspleen-with-micrographism#!/}, doi = {10.7759/cureus.c109}, issn = {2168-8184}, year = {2023}, date = {2023-04-19}, urldate = {2023-04-19}, journal = {Cureus}, volume = {15}, issue = {4}, pages = {c109}, publisher = {Springer Science and Business Media LLC}, abstract = {Wilson disease is an inherited disorder of copper metabolism with an autosomal recessive inheritance pattern (hepatolenticular degeneration). In this case, a 13-year-old child was seen with overall exhaustion, sporadic abdominal discomfort, and shrinking handwriting during the previous 12 months. On clinical examination there was hepatosplenomegaly. Routine blood work revealed anemia, leukopenia, thrombocytopenia, elevated total and indirect bilirubin, alkaline phosphatase and transaminitis. Serum ceruloplasmin is decreased, urine copper excretion is increased. Slit lamp examination revealed Kayser-Fleischer rings in both eyes. Ultrasonography (USG) abdomen confirmed hepatosplenomegaly, coarse echotexture of the liver. MRI Brain revealed the bilateral and diffuse and symmetric hyperintensity of caudate and lentiform nuclei, which are consistent with the neuro-parenchymal changes of Wilson’s disease. We report this case due to its rare incidence and atypical presentation and to highlight the importance of clinical examination in reaching the diagnosis. }, key = {pmid37101801}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Shiza_2023, title = {Acute pancreatitis simulating myocardial infarction: a challenging case}, author = {Saher T. Shiza and Aalok Parajuli and Iqra Samreen and Tripura Padullaparthi and Alaa S. Mohamed and Muhammad Haseeb and Haleema Sadia and Khalid H. Mohamed and Hira Nasir}, url = {https://www.cureus.com/articles/146779-acute-pancreatitis-simulating-myocardial-infarction-a-challenging-case#!/}, doi = {10.7759/cureus.37769}, issn = {2168-8184}, year = {2023}, date = {2023-04-18}, urldate = {2023-04-01}, journal = {Cureus}, volume = {15}, issue = {4}, pages = {e37769}, publisher = {Springer Science and Business Media LLC}, abstract = {Acute pancreatitis is an inflammatory condition with varying local and systemic complications and variable severity. Although rare, cardiovascular complications induced by acute pancreatitis are rarely described in the literature. Epigastric pain with acute pancreatitis often simulates electrocardiographic changes in the absence of coronary artery abnormalities, resulting in a diagnostic dilemma for optimal treatment and management. We underline a case of acute pancreatitis complicated by acute coronary syndrome in a patient who presented with chest heaviness, dyspnea, nausea, and worsening epigastric pain associated with vomiting. Clinical and laboratory evaluations and using imaging modalities were suggestive of acute pancreatitis mimicking myocardial infarction (MI) in the absence of coronary artery abnormalities.}, key = {pmid37214020}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2023b, title = {Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: a systematic review}, author = {Iman Khan and Ahmed A. Elsanousi and Amena M. Shareef and Sameer S. Tebha and Aabiya Arif and Sana Gul}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.804}, doi = {10.1002/iid3.804}, issn = {2050-4527}, year = {2023}, date = {2023-04-12}, urldate = {2023-04-01}, journal = {Immunity, Inflammation and Disease}, volume = {11}, issue = {4}, pages = {e804}, publisher = {Wiley}, abstract = {Background: After introducing Covid-19 vaccines, a few side effects were reported, pityriasis rosea being one of them. Therefore, this study will systematically review its manifestation afteradministration.Methods: Databases were searched, covering a timeline from December 1, 2019 to February 28, 2022. Data were independently extracted and accessed for bias. SPSS statistical software version 25 was used for appropriate inferential statistics. Results: Thirty-one studies were included for data extraction after screening following the eligibility criteria. A total of 111 people were identified to have developed pityriasis rosea or pityriasis rosea-like eruptions after vaccination, out of which 36 (55.38%) were female. The average age of incidence was calculated to be 44.92 years, and 63 (62.37%) people presented after administration of the first dose. It was found popularly in the trunk area, either asymptomatically or with mild symptoms. Meantime the onset, was 8.58 days, and meantime it took to recover, was 6.44 weeks. Conclusion: The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease.}, key = {pmid37102660}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Bhattacharjee_2023, title = {Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak}, author = {Bedanta Bhattacharjee and Abu Md Ashif Ikbal and Atika Farooqui and Ram Kumar Sahu and Sakina Ruhi and Ayesha Syed and Andang Miatmoko and Danish Khan and Jiyauddin Khan}, url = {https://link.springer.com/content/pdf/10.1007/s11696-023-02795-3.pdf?pdf=button}, doi = {10.1007/s11696-023-02795-3}, issn = {0366-6352}, year = {2023}, date = {2023-04-04}, urldate = {2023-04-04}, journal = {Chemical Papers}, volume = {77}, issue = {8}, pages = {4107-4130}, publisher = {Springer Science and Business Media LLC}, abstract = {The outbreak of COVID-19 has caused great havoc and affected many parts of the world. It has imposed a great challenge to the medical and health fraternity with its ability to continue mutating and increasing the transmission rate. Some challenges include the availability of current knowledge of active drugs against the virus, mode of delivery of the medicaments, its diagnosis, which are relatively limited and do not suffice for further prognosis. One recently developed drug delivery system called nanoparticles is currently being utilized in combating COVID-19. This article highlights the existing methods for diagnosis of COVID-19 such as computed tomography scan, reverse transcription-polymerase chain reaction, nucleic acid sequencing, immunoassay, point-of-care test, detection from breath, nanotechnology-based bio-sensors, viral antigen detection, microfluidic device, magnetic nanosensor, magnetic resonance platform and internet-of-things biosensors. The latest detection strategy based on nanotechnology, biosensor, is said to produce satisfactory results in recognizing SARS-CoV-2 virus. It also highlights the successes in the research and development of COVID-19 treatments and vaccines that are already in use. In addition, there are a number of nanovaccines and nanomedicines currently in clinical trials that have the potential to target COVID-19. }, key = {pmid37362791}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Kausar_2023, title = {Blended learning as an interactive teaching learning method for medical undergraduates}, author = {Ruksana Kausar and Tahmeen Jameel and Raisa Faheem and Syed Wasif Hussain and Syyeda Anees}, url = {https://www.academicmed.org/Uploads/Volume5Issue3/69.%20[615.%20JAMP_MEDP]%20314-318.pdf}, doi = {10.47009/jamp.2023.5.3.69}, issn = {2687-5365}, year = {2023}, date = {2023-04-03}, urldate = {2023-04-03}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {5}, issue = {3}, pages = {314-318}, abstract = {Background: Blended learning is the combination of online and face-to-face learning experience. In the recent years it has grown rapidly to be commonly used in education. Nonetheless, the effectiveness of this learning approach has not been completely quantitatively synthesized and evaluated in health education. Through this study we aimed to identify its strengths, weaknesses, from both student’ and lecturers’ viewpoint so that this innovative teaching and learning methods can help improve the students skills in critical thinking and academic achievement in medical education. Objective: The aim of the study was to assess the efficacy of blended learning compared to face-to-face learning. The objectives were to evaluate the perceptions of students on blended learning, to evaluate the perceptions of faculty on blended learning and to evaluate the interdependencies of face to face and online learning in the blended learning course. Methods: The study design and sampling method was prospective interventional study, cluster sampling. The study included 150 students of phase 1 MBBS of 2021-2022 batch and faculty of biochemistry. The students were sensitized to the blended learning module-acid base balance. Consent of the students was taken and importance of research in medical education was explained. The questionnaire used was adapted from the questionnaire in Sagarra and Zapata’s (2008) study. The questionnaire has two parts; one for the students and the other for the faculty. The one for the students has two sections; the first section contains 16 questions which students answered on a 5 point Likert scale. The second section includes one short answer question. The second part has 6 questions for the faculty which were also answered on a 5 point Likert scale. Results: This evaluation showed that blended learning model helped students improve the critical thinking and retaining power because traditional time/place barriers were removed. However, new barriers related to technology by both students and teachers were noted. Conclusions: This study demonstrated different factors that affected the intention to use blended learning in undergraduate medical students and it has also highlighted that the blended way of study was more helpful rather than purely face to face or online learning. }, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Sadiq_2023, title = {A medical student’s insight into set induction: a cross sectional study}, author = {Neeraj Sadiq and Syyeda Anees and Ghulam Subhani and Mohammed Mohsin and Madhipati Sai Krishna}, url = {http://ajms.alameenmedical.org/ArticlePDFs/8%20AJMS%20V16.N2.2023%20p%20140-145.pdf}, issn = {0974-1143}, year = {2023}, date = {2023-04-01}, urldate = {2023-04-01}, journal = {Al Ameen Journal of Medical Sciences}, volume = {16}, issue = {2}, pages = {140-145}, abstract = {Background: Set induction are preliminary measures taken by the teacher to start effectual classroom instruction and training. Objectives: The aim of the study is to familiarize the mode of set induction to MBBS students. To know the perceptions of MBBS students batch wise towards set induction as an introductory step in teaching/learning method. Methods: A Cross sectional study with cluster sampling was done on of second, third and fourth year MBBS students of Deccan College of Medical Sciences. After taking informed consent orally they were introduced to different types of set induction namely case -based scenarios, narratives and audio visual aids, then a questionnaire was given and results were noted and analyzed statistically in R-language software. Results: Among the 312 students that participated, 208 students (66%) answered all questions. Set induction impacts the students immensely and has significant role to play for all the batches 2020(2st year), 2019(3rdYear), 2020(4thyear). There is a statistically significant difference between batches regarding their perceptions towards set induction and was found to be engrossing and applicable. Conclusion: Set induction must be deliberately designed to facilitate its incorporation for smooth teaching learning process. Case based scenario introduction is the most preferred by students, closely followed by narration based and lastly by audio-visual based introduction.}, keywords = {Biochemistry, Community Medicine, Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Seifi_2023, title = {Comparison between clevidipine and nicardipine in cerebrovascular diseases: a systematic review and meta-analysis}, author = {Ali Seifi and Amirhossein Azari Jafari and Seyyed Mohammad Sadeq Mirmoeeni and Muffaqam Shah and Mohammad Javad Azari Jafari and Shahrzad Nazari and Shafagh Asgarzadeh and Daniel Agustin Godoy}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0303846723000604?via%3Dihub}, doi = {10.1016/j.clineuro.2023.107644}, issn = {0303-8467}, year = {2023}, date = {2023-04-01}, urldate = {2023-04-01}, journal = {Clinical Neurology and Neurosurgery}, volume = {227}, pages = {107644}, publisher = {Elsevier BV}, abstract = {Purpose: The term "cerebrovascular diseases (CVDs)" refers to a broad category of diseases that affect the brain's blood vessels and cerebral circulation. Controlling acute hypertension (HTN) by antihypertensive drugs such as clevidipine and nicardipine can be a highly efficient method of lowering the incidence of CVDs. Methods: This is a systematic review and meta-analysis study. The PubMed, Scopus, and Web of Science online databases and a gray literature search were performed to identify potentially eligible studies. The included studies were observational studies that compared adult patients receiving clevidipine or nicardipine for controlling HTN in the setting of CVD. Results: We reviewed 5 final included articles, including 546 patients. The pooled standardized mean difference (SMD) for time to goal SBP was − 0.04 (95 % CI: [−0.66; 0.58], p-value: 0.86, I2: 79.0 %, pooled MD: −12.90 min), meaning that the clevidipine group had a shorter time to goal systolic blood pressure (SBP) than the nicardipine group. The pooled SMD for total volume infusion was − 0.52 (95 % CI: [−0.93; −0.12], p-value: 0.03, I2: 0.0 %, pooled MD: −1118.81 mL), showing a notably lower total volume infused into patients in the clevidipine group. Conclusions: We found that clevidipine reaches the SBP goal faster than nicardipine; however, there was no statistically significant difference between the two drugs. The total volume infused to achieve the goal SBP was significantly lower in the clevidipine group. Further prospective studies are needed to compare clevidipine and nicardipine in CVD patients on a large scale.}, key = {pmid36842290}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2023, title = {Screening of psychosocial morbidity in children with type 1 diabetes mellitus in an urban setting}, author = {Mazher Ali and Syed Mateen and Arifuddin Ahmed and Ayesha Vaseem and Minhajzafar Nasirabadi and Bipin Kumar Sethi and Ateeq Ur Rahman}, url = {https://journals.lww.com/aips/Fulltext/2023/07010/Screening_for_Psychosocial_Morbidity_in_Children.7.aspx}, doi = {10.4103/aip.aip_164_22}, issn = {2588-8358}, year = {2023}, date = {2023-03-31}, urldate = {2023-03-31}, journal = {Annals of Indian Psychiatry}, volume = {7}, issue = {1}, pages = {35-41}, abstract = {Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by absolute insulin deficiency. As per 2015 estimates, the number of affected children (<15 years) in India is estimated to be 70,200 children,[1] contributing almost 8% of the global burden. It poses additional challenges in the form of emotional stress and psychosocial adjustment problems.Materials and Methods: This was a cross-sectional study on 101 subjects. The Strengths and Difficulties Questionnaire (SDQ) was used to survey mental health symptoms and positive attitudes. The Quality of Life (QoL) Questionnaire was used to assess the QoL.Results: The prevalence of Total difficulties score (TDS) with clinically significant problems was seen in 17.6% of the children. A statistically significant positive correlation was found between HbA1c levels and parent-reported TDS scores (r = 0.692, P < 0.0001). As the HbA1c levels increase, the peer problems (r = 0.322, P = 0.008) and prosocial behavior problems (r = −0.254, P = 0.028) significantly increased.Conclusion: The most common abnormal SDQ scores were found in conduct problems (38.2%) and emotional problems (35.3%). Regular monitoring of lipid profile, blood pressure, and renal indices is important to observe the effects of T1DM on end organs, along with timely screening of children and adolescents for diabetes and psychosocial illness, educating the caregivers about diabetes, monitoring of diet, psychosocial illness, and means to cope with them, which can also improve the psychological well-being and in turn QoL of children and adolescents.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Masooduddin_2023, title = {A histopathological study of soft tissue lesions}, author = {Mohammed Masooduddin and Sobia Afreen}, url = {https://www.ijsr.net/archive/v12i3/SR23316192000.pdf}, issn = {2319-7064}, year = {2023}, date = {2023-03-31}, urldate = {2023-03-31}, journal = {International Journal of Science and Research}, volume = {12}, issue = {3}, pages = {1248-1252}, abstract = {Background: Soft tissue is defined as a complex of non - epithelial extra - skeletal structures of the body exclusive of the reticulo - endothelial system glia and supportive tissue of the various parenchymal organs. Aims: To study the following features of soft tissue tumors according to age, sex incidence, Site - specific distribution, most common type and various spectrum of soft tissue tumor in both malignant and benign of soft tissue tumor. Material and Methods: The present cross - sectional study was conducted in the Department of Pathology during the period of September 2016 to September 2020. A total of 100 samples from patient with soft tissue tumors, including both benign and malignant tumors, were analyzed. Conclusion: The large majority of soft tissue tumors are benign, with a very high cure rate rafter surgical excision. Malignant mesenchymal neoplasms amount to less than 1% of the overall burden of malignant tumors but they are life threatening and may pose significant diagnostic and therapeutic challenge. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Banerjee_2023, title = {Disease-X: Accounting for the unknown}, author = {Sumitaksha Banerjee and Qamar Sultana and Dattatreya Mukherjee and Vibhor Agrawal and Vikash Jaiswal and Kusum Paudel}, url = {https://onlinelibrary.wiley.com/doi/10.1002/hsr2.1173}, doi = {10.1002/hsr2.1173}, issn = {2398-8835}, year = {2023}, date = {2023-03-29}, urldate = {2023-03-01}, journal = {Health Science Reports}, volume = {6}, issue = {4}, pages = {e1173}, publisher = {Wiley}, key = {pmid37008815}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Anis_2023, title = {Multicountry cholera outbreak alert in Kenya: current efforts and recommendations}, author = {Heeba Anis and Olivier Uwishema and Ali E. Hamitoglu and Dina Essayli and Sarah El Kassem and Martin S. Rogose and Zeina Al Maaz and Abubakar Nazir}, url = {https://journals.lww.com/international-journal-of-surgery/fulltext/2023/03000/multicountry_cholera_outbreak_alert_in_kenya_.63.aspx}, doi = {10.1097/js9.0000000000000130}, issn = {1743-9159}, year = {2023}, date = {2023-03-24}, urldate = {2023-03-01}, journal = {International Journal of Surgery}, volume = {109}, issue = {3}, pages = {555-557}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, key = {pmid36928043}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohamed_2023, title = {Non-ST-segment elevation myocardial infarction as initial thrombotic event of thrombotic thrombocytopenic purpura: a rare challenging case}, author = {Khalid H. Mohamed and Saher T. Shiza and Iqra Samreen and Adesola A. Agboola and Alaa S. Mohamed and Pavan Kumar Reddy Kalluru and Muhammad Haseeb and Rana Zohaib Munawar and Hira Nasir}, url = {https://www.cureus.com/articles/140930-non-st-segment-elevation-myocardial-infarction-as-initial-thrombotic-event-of-thrombotic-thrombocytopenic-purpura-a-rare-challenging-case#!/}, doi = {10.7759/cureus.36363}, isbn = {2168-8184}, year = {2023}, date = {2023-03-19}, urldate = {2023-03-01}, journal = {Cureus}, volume = {15}, issue = {3}, pages = {e36363}, publisher = {Springer Science and Business Media LLC}, abstract = {Thrombotic thrombocytopenic purpura (TTP) is a rare autoimmune and devastating blood disorder that results in micro-clots throughout the body, leading to tissue damage and organ dysfunction resulting in widespread microangiopathic hemolytic anemia, thrombocytopenia, fever, and neurological symptoms. TTP patients commonly manifest renal and neurological symptoms; however, cardiovascular involvement is not widely reported in the literature. We report a case of non-ST-segment elevation myocardial infarction (NSTEMI) as an initial manifestation of TTP. Although rare, TTP complications must be considered among other possible causes of unexpected thrombocytopenia during acute phase treatment of acute coronary syndrome because of high morbidity and mortality.}, key = {pmid37082484}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Koti_2023, title = {Evaluation of dexmedotomidine and fentanyl as additives to ropivacaine for epidural anaesthesia and post operative analgesia in in lower abdominal and lower limb surgeries}, author = {Vijaya Rekha Koti and Syeda Saniya Shireen and Shaheera Rahman}, url = {https://medicopublication.com/index.php/ijphrd/article/view/19134/16533}, doi = {10.37506/ijphrd.v14i2.19134}, issn = {0976-0245}, year = {2023}, date = {2023-03-15}, urldate = {2023-03-15}, journal = {Indian Journal of Public Health Research & Development }, volume = {14}, issue = {2}, pages = {370-376}, abstract = {Background: The regional anaesthesia has lot of benefits compared to general anaesthesia for lower abdominal and lower limb surgeries. Epidural anaesthesia is an ideal anesthetic technique for lower abdominal and lower limb surgeries. The additives are used with Anesthetics for Early onset of action, To prolong the duration of action, Analgesia and Improving the quality of block.Aims and Objectives: The aim of this study was to study the clinical efficacy of Dexmedetomidine versus Fentanyl as an additive to Ropivacaine for lumbar epidural anaesthesia and post-operative analgesia. Materials and Methods: This study is a prospective randomi ed controlled study involving 90 patients undergoing infraumbilical and lower limb surgeries who will be divided randomly into three groups Group R(n = 30): received 18 ml of 0.5% ropivacaine for epidural anaesthesia and 10 ml of 0.2% ropivacaine boluses for postoperative analgesia; Group RF (n = 30): received 18 ml of 0.5% ropivacaine with 25μg fentanyl for epidural anaesthesia and 10 ml of 0.2% ropivacaine with 10 μg fentanyl boluses for postoperative analgesia; and Group RD (n = 30): received 18 ml of 0.5% ropivacaine with 25 μg dexmedetomidine for epidural anaesthesia and 10 ml of 0.2% ropivacaine with 5 μg dexmedetomidine boluses for postoperative analgesia.Results: Addition of additives have enhanced the onset of action, prolong duration of analgesia. Quality and duration of epidural anaesthesia provided by ropivacaine with dexmedetomidine is more effective than fentanyl. Better efficacy of analgesia evidenced with Dexmedetomidine than with Fentanyl. Conclusion: It can be concluded that RD (Ropivacaine and Dexmedetomidine) when given epidurally can be a safe and effective combination for epidural blockade in lower abdominal and lower limb surgeries.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2023b, title = {Comparison of chloroprocaine and bupivacaine for spinal anaesthesia in patients undergoing day care surgery: a double blind randomized controlled study}, author = {Vijaya Rekha Koti and Syeda Nehha and Rooma and Mohammed Asraruddin and Syeda Hafsa Fatima}, url = {https://medicopublication.com/index.php/ijphrd/article/view/19135/16534}, doi = {10.37506/ijphrd.v14i2.19135}, issn = {0976-0245}, year = {2023}, date = {2023-03-15}, urldate = {2023-03-15}, journal = {Indian Journal of Public Health Research & Development}, volume = {14}, number = {2}, issue = {2}, pages = {377-383}, publisher = {Institute of Medico-legal Publications Private Limited}, abstract = {Background:In the last few years, the number of surgical procedures performed on day care basis has increased worldwide, nearly between 20% - 30% surgeries are being performed as outpatient procedures. Ambulatory surgery has become increasingly popular due to advantages for the individual patient and the positive economic impact for the health care system. In the near future, ambulatory surgery is likely to expand further.Objectives: The objectives of this study were to compare chloroprocaine and bupivacaine for spinal anaesthesia in patients undergoing day care surgery. Methods: Patients between 18-60 years’ age of either sex, belonging to ASA I and ASA II undergoing day care surgeries lasting 45-60 min were included in this study after approval of Institutional Review Board and obtaining informed consent. Preanaesthetic check-up was done one day before surgery patients were evaluated for any systemic diseases and laboratory investigation recorded the procedure of spinal anaesthesia was explained to the patients and written informed consents was obtained. Hundred patients were randomly divided into two groups of fifty each. Fifty patients received 0.5% heavy 10mg (2cc) bupivacaine. Fifty patients received 40mg (4cc)preservative free 2-chloroprocaine. The primary outcome of this study, I. e., the time to eligibility for discharge from hospital, was measured from the time spinal anaesthesia was performed to the time the patient attained all of the discharge criteria.Results : Intrathecal 1% 2-chloroprocaine 40 mg provides spinal anaesthesia of adequate duration for day care surgeries with the advantage of earlier onset and faster regression of spinal block resulting in earlier ambulation and earlier voiding with stable hemodynamic as compared to 0.5% hyperbaric bupivacaine 10 mg.Conclusion: Thus we conclude that 2-chloroprocaine can provide spinal anaesthesia with a shorter recovery profile than bupivacaine, permitting earlier discharge from hospital after day care surgeries.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2023e, title = {Experimental evaluation of anti-ulcer potential of nigella sativa oil in gastric ulcers in albino rats}, author = {Shaima Zafer Khan and Ghulam Subhani and Ayesha Vaseem and Neeraj Sadiq and Mohammed Mohsin}, url = {https://www.jpccr.eu/pdf-162337-88551?filename=Experimental%20evaluation.pdf}, doi = {10.26444/jpccr/162337}, issn = {1898-2395}, year = {2023}, date = {2023-03-01}, urldate = {2023-03-01}, journal = {Journal of Pre-Clinical and Clinical Research}, volume = {17}, issue = {1}, pages = {10-15}, publisher = {Institute of Rural Health}, abstract = {Introduction and objective: Peptic ulcer is a gastrointestinal disease that is characterized by mucosal damage. Nigella sativa (NS) is a medicinal plant increasingly used in practice for treating gastrointestinal diseases. The aim of the study was to evaluate the antiulcer potential of Nigella sativa oil in Albino rats. Material and methods: The study utilized two methods of gastric ulcer induction in Albino rats. The Aspirin-induced gastric ulcer method consisted of 3 groups, with 6 rats in each group, which received pre-treatment once a day orally for 5 days. Group-1 (Control) animals received distilled water. Group-2 (Standard) animals received the standard drug, Ranitidine. Group-3 (Expermintal) animals received the test drug – Nigella sativa oil. The forced swim induced acute gastric ulceration method consisted of 3 groups i.e., control, standard, and test group with 6 rats in each group. After 5 days of respective pre-treatment, the animals were subject to a forced swim test. On day 7, 4 hours after Aspirin ingestion, the animals were sacrificed by stunning. The stomachs of the sacrificed animals was dissected for ulcer scoring. Results: In the Aspirin-induced ulcer method, the percentage protection from ulcer formation was 47.5% in the Nigella sativa group and 52.9% in the standard group. The effect of Nigella sativa oil in comparison to control was statistically significant (p value=0.03). In the forced swim induced acute gastric ulceration method, the percentage protection offered by Nigella sativa oil was 73%, whereas it was 69.6% in the Ranitidine group, and the effect of Nigella sativa oil in comparison to the effect of control was statistically significant (p value=0.03). Conclusions: The study demonstrated that NS oil has significant anti-ulcer potential in rats, which is comparable to the standard drug.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2023c, title = {Was the COVID pandemic suppressing the outbreak of scarlet fever in the United Kingdom?: Correspondence}, author = {Qamar Sultana and Vibhor Agrawal and Vikash Jaiswal and Aroop Mohanty and Ranjit Sah}, url = {https://journals.lww.com/international-journal-of-surgery/fulltext/2023/03000/was_the_covid_pandemic_suppressing_the_outbreak_of.93.aspx}, doi = {10.1097/js9.0000000000000225}, issn = {1743-9159}, year = {2023}, date = {2023-03-01}, urldate = {2023-03-01}, journal = {International Journal of Surgery}, volume = {109}, issue = {3}, pages = {626--628}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, key = {pmid36906776}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2023, title = {Doppler study in second and third trimester in high risk pregnancy and perinatal outcome}, author = {Surayya Tahseen and Thajammul Samrin and Juveriya and Patan Rubeena Khanam and Syed Rubina Taranum and H. Shwetha}, url = {https://www.ejmcm.com/archives/volume-10/issue-2/2623}, issn = {2515-8260}, year = {2023}, date = {2023-03-01}, urldate = {2023-03-01}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {10}, issue = {2}, pages = {962-975}, abstract = {Background: In order to screen for defective placentation and related consequences such pre-eclampsia, intrauterine growth restriction, and infant death, doppler examination of the placental circulation is crucial. Methods: From August 2021 to July 2022, the study was carried out in the Department of Obstetrics & Gynecology, Owaisi Hospital and Research Centre, Hyderabad, Telangana, India. Prospective observational study conducted in a hospital involving 100 patients. Results: Any gestational age after 32 weeks where REDV is detected should warrant consideration for an urgent delivery. Guidelines from the Society for Maternal-Fetal Medicine, which suggest intensive fetal monitoring of these fetuses and continuing expectant treatment until 32 weeks as long as fetal monitoring is still reassuring, support this. Conclusion: Doppler velocimetry can be a valuable addition to standard antepartum surveillance procedures in patients with IUGR fetuses. If other antepartum surveillance tests are reassuring, an abnormal Doppler should not necessitate an obstetric intervention. When an aberrant Doppler finding is discovered, the obstetrician is made aware of the potential problems, and the delivery should be scheduled at a tertiary care center with good neonatal facilities. }, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Rout_2023, title = {Assessment of left ventricular filling pressure and its correlation with severity of chronic kidney disease}, author = {Siddhartha Rout and Mohammed Mudassir Ali and Amritarnav Rout and Mohammed Asif Muzaffer Iqubal}, url = {https://ejmcm.com/issue-content/assessment-of-left-ventricular-filling-pressure-and-its-correlation-with-severity-of-chronic-kidney-disease-2639}, issn = {2515-8260}, year = {2023}, date = {2023-02-28}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {10}, issue = {2}, pages = {1098-1103}, abstract = {Background:Chronic kidney disease (CKD) is a common health problem worldwide. Cardiovascular disease is the most common cause of morbidity and mortality in CKD. In CKD patients, use of Echocardiography can help in establishing a diagnosis of acute decompensated heart failure. Present study was aimed to assessment of left ventricular filling pressure and its correlation with severity of chronic kidney disease. Material and Methods: Present study was single-center, prospective, observational study, conducted patients aged >18 years, either gender, diagnosed cases of CKD as per KIDGO criteria underwent resting 2-D transthoracic echocardiography. Results: In present study, 80 cases of CKD underwent 2-D transthoracic echocardiography evaluation. Majority were from 50-59 years age group (53.75 %), male (66.75 %). In present study majority were from CKD stage 2 (53.75 %) followed by CKD stage 3 (28.75 %), CKD stage 4 (22.5 %) & CKD stage 5 (13.75 %). Among study patients, 45 patients (56.25 %) had normal LVFP, while 27 patients (33.75 %) had 9-13 LVFP & increase in LVFP (> 13) was noted in 8 patients (10 %). Mean value of LVFP in CKD stage 2 was 8.68 ± 2.15, mean LVFP in CKD stage 3 was 10.34 ± 2.64, mean LVFP in CKD stage 4 was 12.92 ± 3.84 & mean LVFP in CKD stage 5 was 13.46 ± 3.23. We noted statistically significant association between increase in stage of CKD with progressive rise in mean LVFP value. Conclusion: The increase in left ventricular filling pressure is directly proportional to the CKD stage i.e., severity of renal failure.}, keywords = {Cardiology, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Mohiddin_2023, title = {A histopathological study in detecting lesions of oesophagus, stomach and duodenum by endoscopic biopsies in adults and children in a tertiary care hospital}, author = {Mohammed Ghouse Mohiddin and T. S. Shamshuddeen and Sobia Afreen and Mariyah Raheem}, url = {https://healthcare-bulletin.co.uk/article?article_id=786&download=true}, issn = {2042-4884}, year = {2023}, date = {2023-02-28}, urldate = {2023-02-28}, journal = {European Journal of Cardiovascular Medicine}, volume = {13}, issue = {2}, pages = {1577-1585}, abstract = {Background: Since its introduction in 1968, the upper gastrointestinal flexible fibre optic endoscope has proven to be a significant advance in the diagnosis of gastrointestinal tract (GIT) abnormalities.With the advent of flexible endoscopy, there has been a noticeable increase in diagnostic procedures requiring visualisation and biopsy of the upper and lower GI tract. Objectives: To correlate clinical diagnosis with histopathological diagnosis in detecting neoplastic lesions. To correlate endoscopic diagnosis with histopathological diagnosis in detecting neoplastic lesions.Material & Methods Hospital based Observational Cross Sectional Study. Study area: The present study was carried out on endoscopic biopsy specimens received in the Department of Pathology, at Princess Esra Hospital and Owaisi Hospital and Research Centre; Deccan College of Medical Sciences. Study Period: 1 year. Study population: Endoscopically directed biopsies were taken from patients with severe upper gastrointestinal symptoms like heart burn, dyspepsia, dysphagia, pain abdomen, vomiting etc. Sample size: study consisted a total of 100 cases. Sampling method: Simple random method.Results: Out of the 100 cases studied, 12 cases were positive for malignancy on histopathology. Out of these 12 cases, 8 cases were diagnosed malignant both on clinical examination and histopathology. 88 cases were negative for malignancy on histopathology, of which 72 cases were negative on both clinical diagnosis and on histopathology. Sensitivity: 66.67 %, Specificity: 81.82 %. Positive predictive value: 33.33 % Negative predictive value: 94.74 %. Accuracy: 80 %, Chi-square test: P-value=0.0025; (The result is significant at P<0.05).Conclusion: Endoscopic procedure in addition with histopathological findings remains the mainstay of diagnostic modality. Our study showed better correlation of histopathological diagnosis with endoscopic findings in detecting lesions of upper GIT. However, endoscopic examination and histopathological study of suspected lesions should always go in parallel and neither of them should be a substitute for each other.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Mughni_2023, title = {Chronic kidney disease of unknown etiology in a tertiary care teaching hospital}, author = {Mohammed A. Mughni and Mohammed A. Mateen and Mohammed Asifuddin and Khaja K. Khan and Ariyan Khan and Maria Khan and Priyadarshi Prajjwal and Raunak Ranjan}, url = {https://www.cureus.com/articles/137335-chronic-kidney-disease-of-unknown-etiology-in-a-tertiary-care-teaching-hospital#!/authors}, doi = {10.7759/cureus.35446}, issn = {2168-8184}, year = {2023}, date = {2023-02-25}, urldate = {2023-02-25}, journal = {Cureus}, volume = {15}, issue = {2}, pages = {e35446}, publisher = {Springer Science and Business Media LLC}, abstract = {Background: Several primary studies have looked at the burden of chronic kidney disease among diabetic patients, but their results have shown significant variance in India. In order to determine the combined prevalence of chronic kidney disease and associated risk factors among patients with diabetes, this study used a combination of methods. Methods: Over the course of two years, a cross-sectional observational study was undertaken in the Tertiary Care Teaching Hospital's Department of General Medicine including all chronic kidney disease patients of 18 years of age and above of either gender. People not suffering from the disease were chosen as controls. Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin-ELISA (NGAL-ELISA) sample analysis by the kit method was done. The study was carried out in accordance with Schedule Y, ICH GCP principles, and the Helsinki Declaration after receiving approval from the institutional ethics committee. Results: In our study, the urinary mean KIM-1 was 49.75±4.35 μg/g Cr in the Chronic Kidney Disease of Unknown etiology (CKDu) group and 1.43±0.15 μg/g Cr in the controls group. The mean NGAL levels of the CKDu Group and the controls group were 8.94±1.31 μg/g and 0.41±0.05 μg/g, respectively. In CKDu and the controls group, the mean eGFR (ml/min/1.73m2) was 69.83±7.91 and 108±3.7, respectively. The mean serum creatinine (mg/dL) was reported 3.79 in the CKDu group and 1.0 in the controls group. Conclusion: Despite the urban centers previously being thought of as a non-endemic location, for the first time in the city, 60 CKDu patients are reported in this study. This is the first study to use the urinary biomarkers KIM-1 and NGAL to find suspected cases of CKDu and early kidney damage in local communities in the urban centers.}, key = {pmid36994299}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2023, title = {Coexistence of congenital myasthenic syndrome and schizophrenia: could there be a genetic link?}, author = {Sandhya Manorenj and Reshma Sultana Shaik}, url = {https://www.neurologyindia.com/temp/ni711180-2164337_060043.pdf}, doi = {10.4103/0028-3886.370441}, issn = {0028-3886}, year = {2023}, date = {2023-02-24}, urldate = {2023-02-24}, journal = {Neurology India}, volume = {71}, issue = {1}, pages = {180-181}, publisher = {Medknow}, key = {pmid36861611}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Vasavada_2023, title = {Carotid endarterectomy versus stenting for the treatment of patients with carotid artery stenosis: an updated systematic review and meta-analysis}, author = {Advait M. Vasavada and Priyansha Singh and Arshia Firdaus and Dakshin Meenashi Sundaram and Malvik Patel and Ganeev Singh and Logesh Palanisamy and Sana Afreen Ansari and Sumaina Thummala and Harsh Pandya}, url = {https://www.cureus.com/articles/138247-carotid-endarterectomy-versus-stenting-for-the-treatment-of-patients-with-carotid-artery-stenosis-an-updated-systematic-review-and-meta-analysis#!/}, doi = {10.7759/cureus.35070}, issn = {2168-8184}, year = {2023}, date = {2023-02-16}, urldate = {2023-02-01}, journal = {Cureus}, volume = {15}, issue = {2}, pages = {e35070}, publisher = {Cureus, Inc.}, abstract = {Carotid endarterectomy (CEA) is a surgical procedure that treats the narrowed carotid arteries, which may be narrowed by atherosclerosis. Stenting is the insertion of a wire mesh scaffold into the narrowed portion of the carotid artery to keep it open by preventing blood from clotting. Using the study done over 10 years back as a point of reference, this study will seek an update on an assessment comparing CEA and stenting in studies carried out between 2015 and to date. The PICOS (population, intervention, control, outcome, and study designs) criteria were used to construct a set of inclusion and exclusion guidelines. This meta-analysis and systematic review used two forms of investigative analysis; both quantitative and qualitative assessments. From the studies, stroke (95% CI: 0.51-0.71, P < 0.001), myocardial infarction (95% CI: 1.49-3.42, P = 0.001), and stroke or death analysis (95% CI: 0.53-0.77, P < 0.001) were noted to be significant. From the analysis, CEA was observed as having better treatment results in terms of stroke events and stroke or death incidences when compared to stenting. Carotid stenting was observed as having lower cases of myocardial infarctions when compared to endarterectomy.}, key = {pmid36942176}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Naveed_2023, title = {Study of modified biophysical profile in IUGR and correlation with perinatal outcome}, author = {Md Amer Naveed and Surayya Tahseen and Thajammul Samrin and Siddenki Nishitha}, url = {https://www.pnrjournal.com/index.php/home/article/view/8468}, doi = {10.47750/pnr.2023.14.S01.154}, issn = {0976-9234}, year = {2023}, date = {2023-02-10}, urldate = {2023-02-01}, journal = {Journal of Pharmaceutical Negative Results}, volume = {14}, issue = {Special Issue 1}, pages = {1120–1133}, abstract = {Background: Intrauterine growth restriction (IUGR) is one of the most common pregnancy complications and it substantially increases the risk of adverse neonatal outcome. Foetal biophysical profile is a well-established method of antepartum surveillance in IUGR patients. The present study was conducted to evaluate the role of modified foetal biophysical profile in IUGR pregnancies for predicting the perinatal outcome. Methods: This was a prospective observational study including 100 pregnancies affected by IUGR. Pregnant women with high risk factors leading to IUGR in ANC OPD admitted in ward or in emergency in Dept. Obstetrics and Gynecology in tertiary care hospital, Hyderabad, who fulfilled the inclusion and exclusion criteria were enrolled for the study. Written, informed, valid consent was taken in the language they best understood. Patients were divided into 4 groups NST and AFI both were normal in 67 cases (Group A). NST was normal and AFI was abnormal in 22 patients (Group B). AFI was normal and NST was abnormal in 5 patients (Group C). Both parameters were abnormal in 6 patients (Group D). Results: out of the 67 patients with adequate AFI and reactive NST, 19 (29%) babies had perinatal morbidity.14 (63.6%) out of 22 patients with inadequate AFI and non-reactive NST had perinatal morbidity. 4 (80%) out of 5 patients with non-reactive NST but normal AFI had some type of perinatal morbidity. While 3(50%) out of 6 patients with non-reactive NST with abnormal AFI had perinatal morbidity (P =0.014). Out of 100 babies, 17 (61%) of those with inadequate AFI has perinatal morbidity, while 23 (32%) with adequate AFI had the same (P&amp;lt;0.01). Conclusion: Modified biophysical profile (MBPP) is easier, less time consuming, cost effective and patient compliant test and hence, can be used as a primary antepartum fetal surveillance test to predict perinatal outcome and provide timely intervention in IUGR pregnancies.}, keywords = {Obstetrics & Gynecology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Siddiquie_2023, title = {Prevalence of vitamin D deficiency in pregnant population at the first antenatal visit}, author = {Asfia Siddiquie and Amera Afeen and Mohammed Jalal Mohiuddin and Md. Jaan Basha and Chavva Shamsunder}, url = {https://journals.lww.com/jasi/fulltext/2022/19020/prevalence_of_vitamin_d_deficiency_in_pregnant.4.aspx}, doi = {10.4103/joasis.joasis_30_22}, issn = {2667-3665}, year = {2023}, date = {2023-02-09}, urldate = {2023-02-01}, journal = {Journal of Orthopaedic Association of South Indian States}, volume = {19}, issue = {2}, pages = {65-69}, publisher = {Medknow Wolters Kluwer}, abstract = {Background: Vitamin D deficiency is a growing health concern and pregnant population is considered to be high risk group. The proposed regimen for the Vitamin D supplementation during pregnancy is 400 IU,1000 IU daily for routine and high risk group (dark skin, obese, inadequate sunlight exposure) respectively. 20,000 units weekly for 6-8 weeks followed by maintenance dose in population with Vitamin D deficiency. The effects of Vitamin D deficiency include pre-eclampsia, increased LSCS incidence, impaired glucose tolerance for mother and low birth weight, hypocalcaemia, poor skeletal growth and immunity for the foetus. Although food may provide small amounts of both vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol), exposure to sunlight is by far the major source of vitamin D to the body, the vitamin being synthesized from cholesterol derivatives. Materials and Method: A cross sectional study over 50 subjects was done after ethical clearance in the department of orthopedics of our medical college. The blood samples along with demographic and clinical data in a questionnaire collected. Results: The results revealed 92% of the study subjects to have either deficiency or insufficiency of vitamin D. The various other parameters contributing directly or indirectly were evaluated. Conclusion and Recommendation: There is need for taking a multidisciplinary approach to patient care and referral to Orthopedics department at the earliest red flags signs of vitamin D deficiency. Creating awareness in the target population can be achieved with counselling and using print media with the pregnancy kits.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Dean_2023, title = {Association between insomnia and the incidence of myocardial infarction: a systematic review and meta-analysis}, author = {Yomna E. Dean and Mohamed A. Shebl and Samah S. Rouzan and Bdoor Ahmed A. Bamousa and Nesreen Elsayed Talat and Sana Afreen Ansari and Yousef Tanas and Muaaz Aslam and Sara Gebril and Taher Sbitli and Ramy Eweis and Rameen Shahid and Amr Salem and Heba Ahmed Abdelaziz and Jaffer Shah and Walaa Hasan and Diaa Hakim and Hani Aiash}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.23984}, doi = {10.1002/clc.23984}, issn = {1932-8737}, year = {2023}, date = {2023-02-01}, urldate = {2023-02-01}, journal = {Clinical Cardiology}, volume = {46}, issue = {4}, pages = {376-385}, publisher = {Wiley}, abstract = {Background: Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods: PubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among insomniacs were included. Revman software version 5.4 was used for the analysis. Results: Our pooled analysis showed a significant association between insomnia and the incidence of MI compared with noninsomniacs (relative risk [RR] = 1.69, 95% confidence interval [CI] = 1.41–2.02, p < .00001). Per sleep duration, we detected the highest association between ≤5 h of sleep, and MI incidence compared to 7−8 h of sleep (RR = 1.56, 95% CI = 1.41–1.73). Disorders of initiating and maintaining sleep were associated with increased MI incidence (RR = 1.13, 95% CI = 1.04–1.23, p = .003). However, subgroup analysis of nonrestorative sleep and daytime dysfunction showed an insignificant association with MI among both groups (RR = 1.06, 95% CI = 0.91–1.23, p = .46). Analysis of age, follow-up duration, sex, and comorbidities showed a significant association in insomniacs. Conclusion: Insomnia and ≤5 h of sleep are highly associated with increased incidence of MI; an association comparable to that of other MI risk factors and as such, it should be considered as a risk factor for MI and to be incorporated into MI prevention guidelines. }, key = {pmid36841256}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Uwishema_2023, title = {Recent measles outbreak in unvaccinated children in Ohio: cause and causality – a correspondence}, author = {Olivier Uwishema and Heeba Anis and Sarah El Kassem and Ali E. Hamitoglu and Dina Essayli and Abubakar Nazir}, url = {https://journals.lww.com/international-journal-of-surgery/fulltext/2023/02000/recent_measles_outbreak_in_unvaccinated_children.42.aspx}, doi = {10.1097/js9.0000000000000215}, isbn = {1743-9159}, year = {2023}, date = {2023-02-01}, urldate = {2023-02-01}, journal = {International Journal of Surgery}, volume = {109}, issue = {2}, pages = {196-197}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, key = {pmid36799850}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hadi_2023, title = {A study on perforations, operative modalities, complications and its outcome post operatively}, author = {Mohammed Abdul Hadi and Atif Abdul Samee and J. Kondal Reddy}, url = {https://www.academicmed.org/Uploads/Volume5Issue1/40.-53.-JAMP_Taqui-190-195.pdf}, doi = {10.47009/jamp.2023.5.1.40}, issn = {2687-5365}, year = {2023}, date = {2023-01-31}, journal = {International Journal of Academic Medicine and Pharmacy}, volume = {5}, issue = {1}, pages = {190-195}, abstract = {Background: To assess to common type of perforations and their presentation, operative modalities, complications arising postoperatively at our hospital. Materials and Methods: It was an observational study; this study is based on analysis of 65 cases of benign cause of gastrointestinal perforation. Result: The time laps between onset of pain and presentation at the hospital was greater in the > 24 hours group with 58.5% of the patients presenting after 24 hours. Peptic ulcer perforation (32.31%) is the major cause of gastrointestinal perforation followed by appendicular (26.4%) tubercular (15.4%) and typhoid (10.8%).80% of cases had guarding /rigidity with 47.7% Patients presented with distention of abdomen. 71% of cases had gas under the diaphragm with majority of them in peptic ulcer perforation and least appendicular perforation. Simple closure with Omental patch was the operative procedure done for all cases of peptic ulcer perforation and appendectomy for appendicular perforation. Half of patients with typhoid perforation closure in two layers and remaining half were treated with resection and end to end anastomosis. Most common Complication recorded in this study was SSI (16.9%) which was similar to that of respiratory infection/distress. Mortality in our study was 3.1% and was due to septicemia with other age group, delayed presentation to hospital and other associated co-morbidities being the additives factors. Conclusion: Finally surgical treatment is the most definitive treatment for perforative paternities patients and postoperative care remain extremely important in the better outcome of the patients.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Jaiswal_2023, title = {Monkeypox-induced myocarditis: a systematic review}, author = {Vikash Jaiswal and Qamar Sultana and Simmy Lahori and Dattatreya Mukherjee and Vibhor Agrawal and Neel Doshi and Abhigan Babu Shrestha and Helen Huang and Yusra Minahil Nasir and Sidra Naz}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883211/pdf/main.pdf}, doi = {10.1016/j.cpcardiol.2023.101611}, issn = {0146-2806}, year = {2023}, date = {2023-01-28}, urldate = {2023-01-28}, journal = {Current Problems in Cardiology}, volume = {48}, number = {pmid36716982}, issue = {5}, pages = {101611}, abstract = {Monkeypox virus has emerged in different parts of the world with varying clinical symptoms and outcomes. To date, only a few studies have reported cardiac manifestations among monkeypox-infected patients. We aim to systematically evaluate the symptoms, imaging findings, management, and outcomes among monkeypox-induced myocarditis patients. We conducted a systematic literature search in PubMed, Embase, and Scopus from inception till 5th January 2023 by using predefined MESH terms and “AND” and “OR.” The following search terms were used: “monkeypox virus” AND “myocarditis.” A total of 6 studies with 9 monkeypox-induced myocarditis patients were included in this analysis. The mean age of patients was 33.6 years, with all being male patients. The most common symptoms were fever (89%) and chest pain (100%). Electrocardiogram findings showed 44% of patients had ST-elevation, and 22% had sinus tachycardia. The echocardiographic findings show a mean ejection fraction of 52.14%, while 57% of patients had preserved ejection fraction, and 67% had normal wall motion. Cardiac magnetic resonance findings show 40% of patients had late gadolinium enhancement, and 40% had edema. Management of patients was primarily supportive (33%), and 33% of patients were administered Beta blockers and ACE inhibitors. Overall all patients survived with a good prognosis. Our study's findings show that all cases were reported among male patients with the most common symptoms of chest pain. The overall prognosis was good, with no mortality reported. Infected patients complaining of chest pain should not be ignored, and proper investigation of myocarditis must be considered.}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2023, title = {Aetiopathogenesis of ischemic stroke in rheumatoid arthritis: a case series study from tertiary care centre of South India}, author = {Sandhya Manorenj and Reshma Sultana Shaik and Sravan Kumar Marupaka }, url = {https://www.msjonline.org/index.php/ijrms/article/view/11415/7500}, doi = {10.18203/2320-6012.ijrms20223655}, issn = {2320-6012}, year = {2023}, date = {2023-01-01}, urldate = {2023-01-01}, journal = {International Journal of Research in Medical Sciences}, volume = {11}, issue = {1}, pages = {323-327}, publisher = {Medip Academy}, abstract = {Stroke is a major health concern worldwide. Published meta-analyses showed significant higher risk of ischemic and hemorrhagic stroke in patients with rheumatoid arthritis (RA) compared to the general population. Major etiopathogenesis of ischemic stroke in RA is non-atherosclerotic vasculopathy. Here the authors described varied aetiopathogensis of ischemic stroke in patients with RA which had been seldom reported in the literature. It was one of the first case series which threw light in this genre. Observational, prospective case series study was conducted over a period of one year. Amongst four cases presenting as an ischemic stroke with co-existing RA; each patient had a medium or small vessel vasculopathy, which had never been described earlier. Case 1 had cardio embolic source plus large vessel vasculopathy, case 2 had intracranial non-atherosclerosis vasculopathy; case 3 had secondary Moya-Moya disease; case 4 had both intracranial and extra cranial vasculopathy. Underlying aetiopathogensis of stroke in patients with RA can be attributed to insufficient cardiovascular treatment (well described in the literature) and vasculopathy of extracranial and intracranial vessels and secondary Moyamoya disease due to RA. Thorough evaluation is needed to prevent recurrence of stroke. The treatment strategy in these patients are immunotherapy apart from the conventional therapy with antiplatelet and statins.}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @inbook{Reddy_2023, title = {Allergen Immunotherapy}, author = {Uppin Narayan Reddy}, editor = {R. Remesh Kumar and R. Krishna Mohan and Neeraj Gupta and Narmada Ashok}, url = {https://jaypeebrothers.com/pgDetails.aspx?cat=s&book_id=9789354659898}, isbn = {9789354659898}, year = {2023}, date = {2023-01-01}, booktitle = {IAP Case Based Reviews in Pediatric Allergy}, pages = {328-334}, publisher = {Jaypee Brothers Medical Publishers (P) Ltd}, address = {New Delhi}, edition = {1st}, chapter = {41}, organization = {Indian Academy of Pediatrics}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {inbook} } @article{Vishwakarma_2023, title = {Simultaneous extraction and quantification of circulating mitochondrial and nuclear DNA using a single plasma sample to predict specific molecular diagnostic implications}, author = {Sandeep Kumar Vishwakarma and Nusrath Fathima and Santosh K. Tiwari and Aleem Ahmed Khan}, url = {https://pdf.sciencedirectassets.com/272218/1-s2.0-S1567724922X00068/1-s2.0-S1567724922001076/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEC4aCXVzLWVhc3QtMSJHMEUCIQCFhJYexwJCvLDwtCzCq5ybzBAkEI5ZvwfXkxvfrboAXgIge2ikPzHMZsp%2Fq2oboo3N%2F%2Fyi%2BakD7EaOFUYh7hTD3j4qswUIJxAFGgwwNTkwMDM1NDY4NjUiDLtcVUv99RPKfnFrxCqQBR5HyFAczXeW8tiWtRyhgIL6Ih9KiRfHqmYhMbnxKoFSLvwgN5gvDMBgX3hA1fvFnoh%2FgIMEpG8P3qeVIT%2BaOmswGOwecRc%2Bi%2F%2Ftgs%2FDXwdckLQY8d3JGsU5LsBg5z0G4%2BIkmMDp7DzcfLR0HHGakJdqheXhgMdJ0MCIPK%2FWJp%2BwIWrnMhzQEs3ckG5JD%2BOkG%2FgyErwbARnPpfh2didcEMk9LwT74iZ%2BgEnutKS2%2BZ7fzXQ9rt6XTja2N6nKinRYbEVKwUZ%2Fd%2FOuf6qTPm8snctNLjQGzGnPQOSagk%2FsEM6T2j3WN%2B1p124GHnT%2Bht6BYtiIHsIxjwyiIhJJ8yGyZWoJ3hccZe%2BMGlyTSvO0UTAEoqMPkF%2FLvFRBCeQVHXwXB5iYvSSKvAOeDWJqa6BcoDLoInBI6y4LOYxh%2Fy8tzQdzF3U0Z%2F5G1FoJQEGbtt%2FgDS5tmrMt3AxvND2OC%2B2jKAbCwQgBRnxYjyRdZxYTtC6UlpNXHlSKHy%2B5F%2F%2BkJfKUQSWZDpzj86HFY6SCg2F6dXb8sh9cT1kfbtLoJFX8Ah7o52Gxa5b3L6cJpQgakBMknq3L9mS3diyWjvbiC1My%2FE4v%2FwEVxZtdcJ%2FyZpK0UVCjYesDhOtdAlSW2jyMvqszvfv8P0fCsDr71mJjACAd9j%2B87Qzlsqtej5KoZwOIEEqjrxusy%2F2SFJY7BC%2F%2B%2BJLWcdCqZPOTiJh5Qi2BBMLolqh66xHHXkfx6D8wzIr0GCiaXZTV%2B1UCcQu%2Fy7nGySOTQU5bfjCFfq25XTp6m7tvfFw2SW3H%2FfbDJMH567jhO6VInbMXZczye2cPH0in6PQFmz7bItDMo%2BK7Py0ntQp%2FL1c%2BOBUhQWfqhOx5n%2BB2DS6aMJ36uagGOrEBbOU5TehdIxyu8Ctrpw4BbLfIyiZb9wkzwFhtiRr1EIx%2B2tfg8gGYY%2BIzNVbtvhLIw39DIbKaIbCNl9xxPor4CC5jJw%2FvAERRhCyPpEo9cIDLgfk7Z7AIXZwLX57YgcNbvulPM40H%2BaYaMzEB%2FNB2KMH5lKFaAm%2BTNKyPaBJe2yCoGzFImiKsH6%2BvugD90qp9xhtRCwV5gTjYtx4EGqXSPYior3J9UQiFpDgRbCiBm8DY&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20230923T071913Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYRZ7E4GVR%2F20230923%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=0d7a5dc29b4d946a1f68dedf15a00a1a40cdc8500bfe6e952eab9d8e0589ebc4&hash=8a761a892fcbb19735062ffbb5d6348f93bd3af790434f5a79e7ad231b537469&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S1567724922001076&tid=spdf-fbc0216d-dc2a-4ff1-be52-a1f1d7f7b923&sid=d3a802bb9c9bc24c5d8ab168346de759acb2gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d5750015655570555&rr=80b104a46beb2e84&cc=in}, doi = {10.1016/j.mito.2022.12.003}, issn = {1567-7249}, year = {2023}, date = {2023-01-01}, urldate = {2023-01-01}, journal = {Mitochondrion}, volume = {68}, pages = {114-124}, publisher = {Elsevier BV}, abstract = {The magnitude of variations in the level of circulating mitochondrial (cir-mtDNA) and nuclear DNA (cir-ncDNA) in different diseases has indicated the need for investigating a discriminative approach for evaluating their diagnostic significance. This study reports a typical in-house process for extracting both types of cir-DNAs from a single plasma sample and assessed their usefulness in discriminating type 2 diabetes mellitus patients from healthy individuals to eliminate the prevailing dispute about their discriminative role and improve their diagnostic value. This approach offers a more precise and valuable tool for distinguishing the impact of cir-mtDNA from cir-ncDNA in diagnostic implications.}, key = {pmid36509340}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @book{Ahmed_2023, title = {Forensic Medicine and Toxicology Theory/Practical skills,Viva}, author = {Khazi Mudabbir Ahmed}, isbn = {978-81-95819-17-1}, year = {2023}, date = {2023-01-01}, booktitle = {Forensic Medicine and Toxicology Theory/Practical skills,Viva}, publisher = {Paras Medical Books Pvt. Ltd.}, address = {Hyderabad}, edition = {3rd}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {book} } @article{Fatima_2022c, title = {A clinical study on methods of anesthesia and its effects on peri-interventional morbidity following rigid bronchoscopy}, author = {Asiya Fatima and Naseeba Fatima and Mohammed Naseeruddin Mujahid and Arjun Peddapally}, url = {http://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue12,Article26.pdf}, issn = {0975-1556}, year = {2022}, date = {2022-12-31}, urldate = {2022-12-31}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {14}, issue = {12}, pages = {192-198}, abstract = {Background: Providing Anesthesia for rigid Bronchoscopy is a challenge to the Anesthetist and ENT surgeon as they both compete for the same Airway. Rigid Bronchoscopy is an interventional procedure requiring General anesthesia of course with different strategies. The range of complications includes both mechanical and systemic types, depending on the technique of anesthesia used. Aim of the study: To assess the Anesthetic strategies used for Rigid Bronchoscopy and their role in peri-interventional morbidity. Methods: 68 patients of rigid Bronchoscopy were included and divided into two groups. Group A included patients in whom Total Intravenous Anesthetics were used (TIVA group) and group B where patients were administered Gaseous anesthetics (Volatile group). In group A, 46 patients were included and in group B 22 patients were included. In comparison, group A patients (TIVA group) consisted of more Hypertensive patients than the group B. Foreign body removal was performed under inhalation anesthesia in 21/68 (30.88%) patients (TIVA group- 11 and 10 Volatile group), Biopsy of Bronchogenic carcinoma was done in 11/68 (16.17%) patients (TIVA group- 06 and 05 Volatile group) and diagnostic Bronchoscopy was done in 14/68 (20.58%) of the patients (TIVA group- 06 and 08 Volatile group) to investigate the cause of hemoptysis. Both the groups of patients received similar ventilation irrespective of the indication for Bronchoscopy. Results: The hemodynamic showed the pre-operative and post-operative arterial blood gas, pulse oximetry and pulmonary function test data. The baseline values of these parameters were similar in the both groups. Post-operative estimation of arterial blood gas (7.42 ± 0.42 vs. 7.35 ± 0.17, P = 0.021) showed a lower PH in the patients who received volatile anesthesia than the TIVA group. But the volatile group patients were found to have a greater forced vital capacity (Volatile: 2.98 ±0.60 vs. TIVA: 2.19 ± 0.62, P = 0.034) than the TIVA group after rigid Bronchoscopy. The Volatile group patients showed greater incidence of systemic complications like Hypertension postoperatively, 14.25% in TIVA group than in Volatile group: 15.25%. Conclusion: The present study concluded that the two methods of anesthesia and ventilation used for rigid Bronchoscopy produced similar results and none of the both have shown to be superior over the other. Propofol and remifentanil combination used in TIVA group was better and appeared to be popular as it had attenuated haemodynamic response during the procedure. Both the groups showed improvement in spirometry mea- surements. The incidence of hypoxia or hypercapnia was also similar.}, keywords = {Anesthesiology, Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2022d, title = {Management of hypertension before, during and after general and orthopedic surgeries a pragmatic approach of anesthetists}, author = {Naseeba Fatima and Asiya Fatima and Arjun Peddapally and J. Hari Babu}, url = {http://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue12,Article10.pdf}, issn = {0975-1556}, year = {2022}, date = {2022-12-31}, urldate = {2022-12-31}, journal = {International Journal of Pharmaceutical and Clinical Research}, volume = {14}, issue = {12}, pages = {78-89}, abstract = {Background: Among all the risk factors encountered before, during and after General and Orthopedic surgeries, Hypertension was considered as the foremost in the minds of all the Anesthetists. However, there is no definite and uniform protocol of using antihypertensive drugs in its management in the Indian literature. The situation such as this initiated the idea of conducting the present clinical trial. Aim of the Study: To study the peri-operative evaluation, care and management of the patient with hypertension undergoing general & orthopaedic surgeries. The objectives were to study the antihypertensive drug usage, types of anesthesia and their effects and side effects on hemodynamics during the surgery and their management strategies in peri-operative period. Methods: A tertiary care center where this cross-sectional, observational study was conducted included patients from General Surgery and Orthopaedics Departments. Patients were examined by the Anesthetists before, during and after the surgeries up to 48 hours postoperative period. The variables included Initial blood pressure, Antihypertensive drugs used, Anaesthesia drugs used, Blood loss during surgery, Blood and Intravenous fluids used during the surgery. Statistical analysis done by using descriptive measures, mean, standard deviation and nonparametric tests and P < 0.05 was taken as significant in the study. Results: 93 Hypertensive patients undergoing General surgery and Orthopedics surgeries were included in this study. A Shpairo Wilk test was applied to test the normality of the subjects. There were 51/93 (54.83%) General surgery patients and 42/93 (45.16%) Orthopedic patients. There were 58 (54.83%) males (General Surgery- 38 (40.86%) and Orthopedic surgery- 20 (21.50%) and 35 (37.63%) female patients (General Surgery- 13 (13.97%) and Orthopedic surgery- 22 (23.65%) in the study. The male to female ratio was 1.28:1. The mean age was 34.85±6.15 years in General Surgery patients and 37.25±4.60 years in Orthopedic patients. Among The General Surgery patients the mean duration of history of Hypertension was 54.86±7.50 months. Among The Orthopedics patients the mean duration of history of Hypertension was 52.31±2.75 months. Conclusion: Intraoperative hemodynamic changes were less in patients who used regularly Beta blockers than other antihypertensive drugs. They had lower heart rate also. Patients on diuretics on the morning of the surgery showed gross hemodynamic changes such as raised Systolic Blood Pressure and Diastolic Blood Pressure. Other antihypertensive drugs did not show significant hemodynamic changes intra-operatively.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2022c, title = {Hyperammonemia presenting as opsoclonus–myoclonus–ataxia–tremor syndrome: a case report}, author = {Sandhya Manorenj and Govind Verma}, url = {https://journals.lww.com/aomd/fulltext/2022/05030/hyperammonemia_presenting_as.9.aspx}, doi = {10.4103/aomd.aomd_6_22}, issn = {2590-3446}, year = {2022}, date = {2022-12-30}, urldate = {2022-12-30}, journal = {Annals of Movement Disorders}, volume = {5}, issue = {3}, pages = {198-201}, abstract = {Opsoclonus myoclonus syndrome (OMS) is a rare autoimmune condition occurring due to Purkinje cell degeneration due to remote aetiology. Most often it occurs as a paraneoplastic syndrome. Here we report a case of opsoclonus-myoclonus–ataxia tremor syndrome in a 60-year-old woman that occurred due to hyperammonemia and she recovered completely with immunotherapy and correction of hyperammonemia. OMS is the first in literature associated with hyperammonemia.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Sarah_2022, title = {COVID-19 vaccine– knowledge, attitude and practices among medical students in Hyderabad}, author = {Sayeedunnisa Sarah and Mohammed Sarosh Ahmed and Sultan Rizwan Ahmad }, url = {https://pimr.org.in/2022-vol10-issue-3/originalarticle10_v2.php}, doi = {10.47799/pimr.1003.12}, issn = {2348-1447}, year = {2022}, date = {2022-12-30}, urldate = {2022-12-01}, journal = {Perspectives in Medical Research}, volume = {10}, issue = {3}, pages = {68-71}, publisher = {Prathima Institute of Medical Sciences}, abstract = {Today as a lot of COVID 19 vaccines are available and are currently used, we conducted a study to assess the knowledge, attitudes and perceptions of medical students in our college. An online survey was conducted through GOOGLE forms. In this study total participants are 155 medical students of which 28.4% (n=44) males and 71.6% (n=111) are females. Effectiveness of vaccine as perceived by participants in our study is 65.2%. The safety of the vaccine as considered by participants in this study is 55.5% In this study it was also noticed that when gender is compared with effectiveness and safety of vaccine both males and females felt equally it is effective as well as safe to take vaccine. There is a need to increase trust among our medical students. The elements that define and build trust must be understood and interventions like health awareness programs as role plays, talks on social media involving known personalities can be undertaken and crafted accordingly to improve the knowledge regarding COVID 19. Most of the seniors shared their readiness to take the vaccine than junior students. It was also found that seniors felt that they do not get enough information about vaccines when compared to juniors. The main source of information regarding COVID 19 vaccine for majority of the participants i.e., 71% (n=110) was through internet and social media and 16.8% (n=26) get from health care workers and the least number of participants got information from family and friends. Hence social media and internet can be used in a more appropriate way to remove vaccine hesitancy.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Kommuru_2022, title = {Utilization of hematopoietic stem cell transplantation for acute myeloid leukemia and related hospital outcomes: a cross-sectional study of US hospitals}, author = {Sravani Kommuru and Sowmya Sagireddy and Adit M. Patel and Hruday Raj Thoutam and Saaniya Yasmeen and Amr A. Jarrad and Gagan Kaur and Viralkumar Patel}, url = {https://www.cureus.com/articles/117188-utilization-of-hematopoietic-stem-cell-transplantation-for-acute-myeloid-leukemia-and-related-hospital-outcomes-a-cross-sectional-study-of-us-hospitals#!/}, doi = {10.7759/cureus.32821}, issn = {2168-8184}, year = {2022}, date = {2022-12-22}, urldate = {2022-12-01}, journal = {Cureus}, volume = {14}, issue = {12}, pages = {e32821}, publisher = {Cureus, Inc.}, abstract = {Background: In this study, we aimed to provide a descriptive overview of the utilization of hematopoietic stem cell transplantation (HSCT) for the treatment of acute myeloid leukemia (AML), determine the rates of HSCT use stratified by patients’ demographic characteristics, and measure the hospitalization outcomes. Methodology: We conducted a cross-sectional study using the Nationwide Inpatient Sample (NIS) obtained from hospitals in the United States. Our sample included 21,385 adult patients (aged ≥18 years) with a primary discharge diagnosis of AML. The sample was further grouped by inpatients who were managed with HSCT and chemotherapy as the primary procedure. We compared the demographic characteristics and hospital outcomes in AML inpatients across treatment cohorts by performing descriptive statistics and Pearson’s chi-square test. Next, we measured the differences in continuous variables (length of stay and cost) using the analysis of variance (ANOVA). All analyses were conducted using SPSS version 26 (IBM Corp., Armonk, NY, USA). Results: The hospital-based utilization rate of HSCT was 0.4% in AML inpatients. The utilization rate of HSCT was higher in females (0.5%), African Americans (0.6%), those with median household incomes above the 50th percentile (0.5%), and those covered by private insurance (0.8%). A significantly higher proportion of AML inpatients with HSCT had depression (22.2% vs. 11.4% in total). AML inpatients receiving HSCT had significantly longer hospitalization stays and higher treatment costs than those receiving chemotherapy. The all-cause inpatient mortality was 11.6% in AML inpatients. Statistically, there were no significant differences by treatment. Conclusions: HSCT appears to be underutilized for the treatment of AML. This treatment had a higher utilization rate in females and those from high-income families and was covered by private insurance. The utilization of chemotherapy and HSCT did not significantly differ in the presence of comorbidities, except for depression and hypertension having a higher utilization of HSCT.}, key = {pmid36694524}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2022, title = {A study of correlation between uric acid and ejection fraction in heart failure}, author = {Mohammed Mudassir Ali and Mohammed Asif Muzaffer Iqubal and Muhammad Jawed Ali}, url = {https://healthcare-bulletin.co.uk/article/volume-12-issue-4-pages85-92-ra/}, issn = {2042-4884}, year = {2022}, date = {2022-12-19}, urldate = {2022-12-19}, journal = {European Journal of Cardiovascular Medicine}, volume = {12}, issue = {4}, pages = {85-91}, abstract = {Introduction: Chronic heart failure (CHF) is a leading etiology for both morbidity and mortality on a global level, resulting in an increase in both prevalence and health care costs. Recently, our understanding has changed from a mere hemodynamic condition to a much more complicated approach, including neuroendocrine and immune activation. Uric acid (UA) is the end product of purine breakdown and is excreted by the kidneys. Xanthine oxidase and xanthine dehydrogenase are two enzymes responsible for uric acid breakdown and production. Both enzymes catalyze the oxidation of hypoxanthine to xanthine which is the main enzyme in purine metabolism and contribute to the generation of oxygen free radicals which increased oxidative stress. Materials and Methods: This is an observational study conducted at tertiary care Teaching Hospital over a period of 1 year. All patients who are admitted with symptoms and signs of Heart Failure in the wards like Intensive Care Unit, Acute Medical Care, Intensive Cardiac Care unit, Medical Wards, Cardiac Wards both paid and general rooms were recruited in the study. The sample size was 100 patients after evaluation by clinical and 2D echocardiography findings. Patients with signs and symptoms of Heart Failure and by satisfying inclusion and exclusion criteria were recruited. Results: A total of 100 patients with heart failure and ejection fraction less than 50 who presented to the department of general medicine. 26 male patients had ACS as the precipitating cause of heart failure compared to 29 female patients. In the present study the range of uric acid was observed between 7.1 – 10 mg/dl, the mean uric acid levels were observed to be 8.6 ± 0.67. In the present study, the range of Ejection fraction was observed between 28 – 48%, the mean ejection fraction was observed to be 34.8 ± 6.65. In the present study, it was observed that there was a significant and inverse correlation observed between uric acid levels and ejection fraction r = -0.808 p<0.001. Conclusions: These data suggest that there is a link between heart failure and the level of uric acid, where one can infer that the metabolic derangements that induce an increase in serum uric acid are likely responsible for the increase in morbidity and mortality as a result of hyperuricemia heart failure patients. In addition, in patients newly diagnosed with hyperuricemia, the risk of identifying a lower ejection fraction is higher.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ali_2022b, title = {Comparative study to evaluate safety and efficacy of metformin versus sitagliptin alone and combination in type 2 diabetes mellitus}, author = {Mohammed Mudassir Ali and Suhail Bin Ahmed and Muhammad Jawed Ali}, url = {https://www.healthcare-bulletin.co.uk/article?title=Comparative+Study+to+Evaluate+Safety+and+Efficacy+of+Metformin+versus+Sitagliptin+Alone+and+Combination+in+Type+2+Diabetes+Mellitus_214}, issn = {2042-4884}, year = {2022}, date = {2022-12-19}, journal = {European Journal of Cardiovascular Medicine}, volume = {12}, issue = {4}, pages = {93-97}, abstract = {Introduction: Type 2 Diabetes mellitus (Type 2DM) is chronic, lifelong progressive metabolic disease characterized by hyperglycaemia due to absolute or relative insulinopaenia. Monotherapy with Metformin, a biguanide agent acts primarily as an insulin sensitizer. Its primary clinical site of action is in the liver, improving hepatic insulin sensitivity and as a result, decreasing hepatic gluconeogenesis. Sitagliptin is an oral, highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of patients with Type 2 Diabetes Mellitus. Sitagliptin inhibits the enzymatic degradation and inactivation of glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic peptide (GIP) by DPP-4 the major incretins involved in glucose homeostasis, thereby increasing insulin release and lowering glucagon secretion in a glucose dependent manner. Material and Methods: This is an Open label, Randomized, Parallel group, Comparative and Prospective clinical study. Study was conducted in Type 2DM patients attending the outpatient department of Medicine in tertiary care center. Inclusion criteria: Patients of either sex having age group between 30 -60 years, Patients willing to participate and willing to give written informed consent prior to any study-related procedures and to comply with the requirements of the study protocol. Patients having newly diagnosed Type II DM with prandial blood glucose levels >200 mg/dl and <250 mg/dl. HbAlc in the range of 6.5 to 8.5 % at screening and BMI >27 kg/m2 Results: The mean fasting blood glucose level in Group I at baseline was 150.81±11.61 mg/dl, in Group II was 151.92±10.44 mg/dl and in Group III was 150.53±11.64. The mean fasting blood glucose level in Group I after 3 months was 99.73±9.91 mg/dl, in Group II was 92.72±9.82 mg/dl and in Group III was 85.72±9.82 mg/dl. These was statistically highly significant difference in mean Fasting Blood Glucose level at baseline versus after 3 months in Group I, Group II and Group III (p<0.0001). Group I the mean of HbA1c level was 8.41±1.91% at baseline and 6.99±1.83% after 3rd month. In Group II the mean of HbA1c level was 8.367±1.83% at baseline, 6.65±1.73% after 3rd month. In Group III the mean of HbA1c level was 8.63±1.81% at baseline and 6.44±1.43% after 3rd month. Conclusion: Sitagliptin with Metformin causes efficient glycaemic control with less significant adverse reaction but the gylcaemic control of patients taking Sitagliptin with Metformin was slightly better as compared to patients taking alone. Thus, concluding Sitagliptin with Metformin to be more efficacious than alone. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2022d, title = {Repurposed oral tapentadol as an intravenous drug of abuse in opioid dependence}, author = {Arshiya Fathima and Minhajzafar Nasirabadi and Arifuddin Ahmed and Mazher Ali }, url = {https://journals.lww.com/tjpy/fulltext/2022/08020/repurposed_oral_tapentadol_as_an_intravenous_drug.13.aspx}, doi = {10.4103/tjp.tjp_48_22}, issn = {2455-8559}, year = {2022}, date = {2022-12-16}, urldate = {2022-01-01}, journal = {Telangana Journal of Psychiatry}, volume = {8}, issue = {2}, pages = {116-119}, publisher = {Medknow}, abstract = {We present to you a case series of a group of individuals who presented to us with a history of intravenous drug abuse of repurposed oral tapentadol. Tapentadol is a synthetic benzenoid with a dual mode of action, as an agonist for the μ-opioid receptor and a norepinephrine reuptake inhibitor, with potential anti-nociceptive activity. The prevalence of current opioid use in India is reported to be 4% in males and 0.2% in females. Limited availability and difficulty in procuring the recommended drugs for detoxification and maintenance therapy in opioid dependence give reasons to consider treatment alternatives for the same. This case series aims to address the need and effectiveness of evidence-based treatment in opioid dependence.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Muzammil_2022, title = {SSPE with ocular manifestation “Eye as window to the brain"}, author = {Mohammed Muthiuddin Muzammil and Khuteja Fatima and Habib Khan Gulab Khan Pathan}, url = {https://irispublishers.com/ann/pdf/ANN.MS.ID.000821.pdf}, doi = {10.33552/ANN.2022.13.000821}, issn = {2641-1911}, year = {2022}, date = {2022-12-14}, urldate = {2022-12-14}, journal = {Archives in Neurology & Neuroscience}, volume = {13}, issue = {5}, pages = {1-3}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Sudula_2022, title = {MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma}, author = {Mrudula Sudula and Meda Tejaswi and Naushaba Tazeen and Tasneem Fathima}, url = {https://www.ijpo.co.in/journal-article-file/17932}, doi = {10.18231/j.ijpo.2022.082}, issn = {2394-6784}, year = {2022}, date = {2022-12-14}, urldate = {2022-12-14}, journal = {Indian Journal of Pathology and Oncology}, volume = {9}, issue = {4}, pages = {342-346}, publisher = {IP Innovative Publication Pvt Ltd}, abstract = {Giant juvenile fibroadenoma is a rare variant of more common benign lesion, fibro adenoma observed in younger population. They present with rapidly enlarging single or multiple breast masses in one or both the breast. A 10-year-old pre-pubertal girl presented with large lump in left breast followed by right breast lump. FNAC was suggestive of fibroadenoma, and histopathology confirmed the diagnosis. To understand the genetic basis of common entity like fibroadenoma with a rare presentation in very young age, the tissue block was subjected to gene sequencing and identified MED 12 gene mutation. It leads us to the possibility of new treatment modalities of targeting the causative gene and thus sparing the patient from invasive procedures.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Nazki_2022, title = {Serum levels of vitamin D and lipid profile in patients with polycystic ovary syndrome: a comparative study}, author = {Faizan I Asrar Nazki and Syyeda Anees and Haamid Bashir and Sara Mohammed and Mohsin Wazir}, url = {https://ejmcm.com/uploads/paper/c7717b740dc1dad8a86f313e358265f6.pdf}, issn = {2515-8260}, year = {2022}, date = {2022-12-01}, urldate = {2022-12-01}, journal = {European Journal of Molecular and Clinical Medicine}, volume = {9}, issue = {1}, pages = {686-694}, abstract = {Background: Polycystic ovarian syndrome (PCOS) is one of the most frequent endocrine illnesses in women of reproductive age. It affects around 5-10% of the world's population. Irregular menstrual cycles, prolonged anovulation and hyperandrogenism are all symptoms of the disease. Hyperinsulinemia, insulin resistance, gestational diabetes, type 2 diabetes, dyslipidemia and cardiovascular disease may develop over time. Aim:To compare the lipid profile and vitamin D levels in women with and without PCOS in relation to obesity and to determine the Luteinizing hormone[LH], FollicleStimulating Hormone[FSH], prolactin[prl] levels in women with PCOS in relation to obesity.Method: A total of 152 subjects were taken for the study.76 PCOS patients were identified ultrasonographically and clinically from November 2015 to July 2017, and 76 normal menstruatingwomen served as controls in the study conducted at Deccan Medical College and Princess EsraHospital, Hyderabad. All the subjects were categorized as obese or lean based on their BMI.Results: In comparison to obese participants without PCOS, PCOS obese subjects had higher TG and TC levels and lower HDL levels, according to the study. When compared to lean subjects without PCOS, PCOS lean subjects had higher TG, TC, and LDL values. The HDL levels of PCOS lean patients were observed to be lower than those of lean subjects without PCOS. Vitamin D levels were also shown to be considerably lower in PCOS patients (both obese and non-obese) than in healthy controls.Conclusion: Supplementary retrospective data-based revisions and randomized meticulous tests with recurrent Vitamin D estimations are required to determine whether Vitamin D deficiency is a co-determinant of hormonal and metabolic irregularities in PCOS, a byproduct of hormonal and metabolic un-evenness in PCOS, or both.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Nelakurthi_2022, title = {Comparison of intravenous morphine to unilateral erector spine block in postoperative analgesia following percutaneous nephrolithotomy}, author = {Rama Krishna Nelakurthi and Vinod Kumar V. S.}, url = {http://impactfactor.org/PDF/IJTPR/12/IJTPR,Vol12,Issue11,Article18.pdf}, issn = {0975-5160}, year = {2022}, date = {2022-11-30}, urldate = {2022-11-30}, journal = {International Journal of Toxicological and Pharmacological Research}, volume = {12}, issue = {11}, pages = {143-148}, abstract = {Background: Acute postoperative pain is recently seen following PCNL where an ultrasound-guided block can be advantageous which manages pain along with reduced complication risks and better nerve visualization. Analgesic after PCNL can be delivered with ESP block without severe side effects. Aim: To comparatively assess the safety and efficacy of ultrasound-guided ESP block at the T8 level for intraoperative and postoperative analgesia in subjects undergoing PCNL (percutaneous nephrolithotomy) surgeries. Methods: 120 subjects of ASA-II were divided into 2 groups of 60 subjects each. Following general anesthesia induction, subjects were given an ultrasound-guided Erector Spinae plane (ESP) block before the surgical incision was given. Another 60 age and gender-matched subjects served as controls where general anesthesia without ESP block was given before surgical incision. Results: Intraoperative morphine use was significantly higher in controls compared to Group I subjects with p=0.001. VAS scores were significantly higher for Group II compared to Group I with p<0.05. On assessing the consumption of analgesics and additional morphine in the study participants, analgesics consumption was 0 (0-1) for Group I and was significantly higher for group II with 1 (1-2). This was statistically significant with p=0.001. Overall morphine consumption was also significantly higher in Group II with 25.68±3.65 compared to Group I with ultrasound-guided erector spinae plane block with 15.01±5.27mg with p<0.001. Conclusion: The study concluded that satisfactory analgesic effects are seen with the ultrasound-guided ESP block at T8 transverse level in subjects undergoing PCNL (percutaneous nephrolithotomy). The postoperative pain was higher in controls and morphine was less used with ultrasound-guided ESP blocks.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Mirmoeeni_2022, title = {The clinical, diagnostic, therapeutic, and prognostic characteristics of brain metastases in prostate cancer: a systematic review}, author = {Seyyed Mohammad Sadeq Mirmoeeni and Amirhossein Azari Jafari and Muffaqam Shah and Fateme Salemi and Seyedeh Zohreh Hashemi and Ali Seifi }, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719815/pdf/PC2022-5324600.pdf}, doi = {10.1155/2022/5324600}, issn = {2090-3111}, year = {2022}, date = {2022-11-27}, urldate = {2022-11-27}, journal = {Prostate Cancer}, volume = {2022}, pages = {1-18}, abstract = {Aim: Prostate cancer (PCa) is the second most common nonskin malignancy and the second most common cause of cancer-related deaths in men. The most common site of metastasis in PCa is the axial skeleton which may lead to back pain or pathological fractures. Hematogenous spread to the brain and involvement of the central nervous system (CNS) are a rare occurrence. However, failed androgen deprivation therapy (ADT) may facilitate such a spread resulting in an advanced metastatic stage of PCa, which carries a poor prognosis. Methods: In this systematic review, we searched the PubMed, Scopus, and Web of Science online databases based on the PRISMA guideline and used all the medical subject headings (MeSH) in terms of the following search line: ("Brain Neoplasms" OR "Central Nervous System Neoplasms") and ("Prostatic Neoplasms" OR "Prostate"). Related studies were identified and reviewed. Results: A total of 59 eligible studies (902 patients) were included in this systematic review. In order to gain a deeper understanding, we extracted and presented the data from included articles based on clinical manifestations, diagnostic methods, therapeutic approaches, and prognostic status of PCa patients having BMs. Conclusion: We have demonstrated the current knowledge regarding the mechanism, clinical manifestations, diagnostic methods, therapeutic approaches, and prognosis of BMs in PCa. These data shed more light on the way to help clinicians and physicians to understand, diagnose, and manage BMs in PCa patients better.}, key = {pmid36474619}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Alla_2022, title = {Dengue & COVID-19: a comparison and the challenges at hand}, author = {Deekshitha Alla and Sai Santhosha Mrudula Alla and Roopeessh Vempati and Heom Bhatt and Qamar Sultana and Siddharth Bhatt and Tahsina Mohsin and Ayesha Siddiqua}, url = {https://www.cureus.com/articles/125185-dengue--covid-19-a-comparison-and-the-challenges-at-hand#!/}, doi = {10.7759/cureus.31877}, issn = {2168-8184}, year = {2022}, date = {2022-11-25}, urldate = {2022-11-01}, journal = {Cureus}, volume = {14}, issue = {11}, pages = {e31877}, publisher = {Cureus, Inc.}, abstract = {The COVID-19 pandemic caused by SARS-CoV-2 spread across many countries between 2020 and 2022. The similarities in clinical presentation with other endemic diseases pose a challenge to physicians in effectively diagnosing and treating the infection. Approximately 129 nations have a risk of dengue infection, and more than 100 of those are endemic to dengue. During the COVID-19 pandemic, the number of dengue cases decreased in many countries owing to the isolation measures followed. However, the common clinical presentation between them has led to misdiagnosis. Both COVID-19 and dengue fever cause a surge in pro-inflammatory cytokines and chemokines, thus sharing a common pathophysiology. False positive serological test results also posed difficulty differentiating between COVID-19 and dengue fever. This review aims to compare the clinical features, pathophysiology, and immune response between dengue and COVID-19, to benefit public health management during the pandemic.}, key = {pmid36579259}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_Suheb_2022, title = {A case of cyanosis with saturation gap: dapsone-induced methemoglobinemia}, author = {Mahammed Khan Suheb and Farheen Naaz and Tyler K. Anderson and Alexander McClanahan}, url = {https://www.cureus.com/articles/76080-a-case-of-cyanosis-with-saturation-gap-dapsone-induced-methemoglobinemia#!/}, doi = {10.7759/cureus.31684}, issn = {2168-8184}, year = {2022}, date = {2022-11-19}, urldate = {2022-11-01}, journal = {Cureus}, volume = {14}, issue = {11}, pages = {e31684}, publisher = {Cureus, Inc.}, abstract = {Dapsone is an antibiotic used in the management of dermatologic infections and opportunistic infection prophylaxis in developed countries. Methemoglobinemia (MetHb) is a known complication of dapsone use that can result in cyanosis. MetHb is an aberrant form of hemoglobin produced physiologically by auto-oxidation. An impairment in the process of auto-oxidation due to genetic defects or the use of drugs/toxins causes its levels to rise. Management involves timely recognition and the use of methylene blue (MB) or ascorbic acid. We describe the diagnosis and management of a patient with acquired MetHb as a result of dapsone use.}, key = {pmid36561581}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Naveed_2022, title = {Sputum culture and antibiogram in infective acute exacerbation of chronic obstructive pulmonary disease in a tertiary care hospital in India}, author = {M. Aleemuddin Naveed and Syed Aamir Ali and Urooj Ahmedi and Syed Mujtaba Quadri and Kashifa Butool and Qursheed Sultana }, url = {https://www.ijcdas.com/doi/pdf/10.5005/ijcdas-60-1-13}, doi = {10.5005/ijcdas-60-1-13}, issn = {0377-9343}, year = {2022}, date = {2022-11-01}, urldate = {2022-11-01}, journal = {The Indian Journal of Chest Diseases and Allied Sciences}, volume = {60}, issue = {1}, pages = {13-18}, publisher = {Jaypee Brothers Medical Publishing}, abstract = {Background. Infections are the common cause of death in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods. A prospective cohort study was conducted on 100 patients with AECOPD in a tertiary care hospital in Hyderabad city in South India. Sputum culture of 100 patients was evaluated for the presence of Gram-positive and Gram-negative micro-organisms. Sensitivity and resistance patterns of the micro-organisms against commonly used antibiotics were also investigated.Results. During the period October 2015 to April 2016, 67% of the patients had sputum culture positive for the presence of pathogenic micro-organisms. Pathogens, most commonly, isolated were Gram-negative organisms like Klebsiella oxytoca (13%), followed by Klebsiella species (11%) and Klebsiella pneumoniae (10%). Amikacin was found to be the most effective antibiotic against all micro-organisms. A significantly higher proportion of organisms were pathogenic compared to non-pathogenic organisms (p=0.0014). Among pathogenic organisms, a significantly higher proportion of Gram-positive organisms were found compared to Gram-negative organisms (p=0.0180). Pathogenic micro-organisms showed a high resistance rate to commonly used antibiotics. Except few strains of Klebsiella, Pseudomonas and Streptococcus, overall 62.9% strains were sensitive to doxycycline.Conclusions. Our observations suggest that doxycycline can be used as an empirical antibiotic in the treatment of AECOPD.}, keywords = {Deccan School of Pharmacy, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Tripura_2022, title = {Long-term and non-invasive in vivo tracking of DiD dye-labeled human hepatic progenitors in chronic liver disease models}, author = {Chaturvedula Tripura and Srinivas Gunda and Sandeep Kumar Vishwakarma and Avinash Raj Thatipalli and Jedy Jose and Mahesh Kumar Jerald and Aleem Ahmed Khan and Gopal Pande}, url = {https://f6publishing.blob.core.windows.net/73565c43-217d-4006-bcc5-e229b8c8ec9f/WJH-14-1884.pdf}, doi = {10.4254/wjh.v14.i10.1884}, isbn = {1948-5152}, year = {2022}, date = {2022-10-27}, urldate = {2022-10-27}, journal = {World Journal of Hepatology}, volume = {14}, issue = {10}, pages = {1884-1898}, publisher = {Baishideng Publishing Group Inc.}, abstract = {BACKGROUND: Chronic liver diseases (CLD) are the major public health burden due to the continuous increasing rate of global morbidity and mortality. The inherent limitations of organ transplantation have led to the development of stem cell-based therapy as a supportive and promising therapeutic option. However, identifying the fate of transplanted cells in vivo represents a crucial obstacle. AIM: To evaluate the potential applicability of DiD dye as a cell labeling agent for long-term, and non-invasive in vivo tracking of transplanted cells in the liver. METHODS: Magnetically sorted, epithelial cell adhesion molecule positive (1 × 106 cells/mL) fetal hepatic progenitor cells were labeled with DiD dye and transplanted into the livers of CLD-severe combined immunodeficiency (SCID) mice. Near-infrared (NIR) imaging was performed for in vivo tracking of the DiD-labeled transplanted cells along with colocalization of hepatic markers for up to 80 d. The existence of human cells within mouse livers was identified using Alu polymerase chain reaction and sequencing. RESULTS: NIR fluorescence imaging of CLD-SCID mice showed a positive fluorescence signal of DiD at days 7, 15, 30, 45, 60, and 80 post-transplantation. Furthermore, positive staining of cytokeratin, c-Met, and albumin colocalizing with DiD fluorescence clearly demonstrated that the fluorescent signal of hepatic markers emerged from the DiD-labeled transplanted cells. Recovery of liver function was also observed with serum levels of glutamic-oxaloacetic transaminase, glutamate-pyruvate transaminase, and bilirubin. The detection of human-specific Alu sequence from the transplanted mouse livers provided evidence for the survival of transplanted cells at day 80. CONCLUSION: DiD-labeling is promising for long-term and non-invasive in vivo cell tracking, and understanding the regenerative mechanisms incurred by the transplanted cells. }, key = {pmid36340748}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2022b, title = {Adult autoimmune enteropathy in India: a rare entity and unusual presentation}, author = {Sheraz Ahmed and Ganji Ravi}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/adult-autoimmune-enteropathy-in-india--a-rare-entity-and-an-unusual-presentation_October_2022_3556810261_8112221.pdf}, doi = {10.36106/ijsr/8112221}, issn = {2277-8179}, year = {2022}, date = {2022-10-01}, urldate = {2022-10-01}, journal = {International Journal of Scientific Research}, volume = {11}, issue = {10}, pages = {24-26}, publisher = {World Wide Journals}, abstract = {Introduction: Autoimmune enteropathy is an X-linked autoimmune disease. A syndrome of intractable diarrhea, varying levels of villous atrophy of small intestine , presence of circulating autoantibodies to enterocytes. Diagnostic criteria is any 3 of the following features 1) features of malabsorption 2) Diarrhea > 6 weeks 3) HPE showing villous blunting with crypt and intraepithelial lymphocytosis 4) exclusion of other causes of villous atrophy like celiac disease and refractory sprue 5) serology positive for antibodies like anti-enterocyte and anti-goblet. Aims & objectives:The aim of this case report was to report a rare case of autoimmune enteropathy in an Indian female , with an atypical presentation with diagnosticand treatment challenges. The typical presentation of autoimmune enteropathy is chronic diarrhea with features of malnutrition andDiscussion:weight loss. But the presentation in this patient was more in favour of presentation of koch's abdomen , mostly of TB peritonitis with ascitic component. . Adult autoimmune enteropathy being a rare entity is thought late in differential diagnosis. The presence of antibodies , intraoperative findings and response to steroids favour autoimmune enteropathy. Although AIE is a rare entity,a multifactorial and a high degree of suspicion is necessary for diagnosis. In a country like India, where tuberculosis is so prevalent, other differential diagnosis should also be thought. Conclusion:of before coming to a conclusion.,as other diseases like autoimmunity previously thought to be rare are not so. ATT should only be started after confirming the diagnosis with histopathology report.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Dhar_2022, title = {Clinical outcomes of bronchiectasis in India: data from the EMBARC/Respiratory Research Network of India registry}, author = {Raja Dhar and Sheetu Singh and Deepak Talwar and B. V. Murali Mohan and Surya Kant Tripathi and Rajesh Swarnakar and Sonali Trivedi and Srinivas Rajagopala and George D'Souza and Arjun Padmanabhan and B. Archana and P. A. Mahesh and Babaji Ghewade and Girija Nair and Aditya Jindal and Gayathri Devi H. Jayadevappa and Honney Sawhney and Kripesh Ranjan Sarmah and Kaushik Saha and Suresh Anantharaj and Arjun Khanna and Samir Gami and Arti Shah and Arpan Shah and Naveen Dutt and Himanshu Garg and Sunil Vyas and Kummannoor Venugopal and Rajendra Prasad and M. Aleemuddin Naveed and Saurabh Karmakar and Virendra Singh and S. K. Jindal and Shubham Sharma and Deepak Prajapat and Sagar Chandrashekar and Michael Loebinger and Aditi Mishra and Francesco Blasi and Ramanathan Palaniappan Ramanathan and Pieter C. Goeminne and Preethi Vasudev and Amelia Shoemark and B. S. Jayaraj and Rahul Kungwani and Akanksha Das and Mehneet Sawhney and Eva Polverino and Tobias Welte and Nayan Sri Gulecha and Michal Shteinberg and Anshul Mangala and Palak Shah and Nishant Kumar Chauhan and Nikita Jajodia and Ashutosh Singhal and Sakshi Batra and Ashfaq Hasan and Stefano Aliberti and Megan L. Crichton and Sneha Limaye and Sundeep Salvi and James D. Chalmers}, url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC9816417/pdf/ERJ-00611-2022.pdf}, doi = {10.1183/13993003.00611-2022}, issn = {0903-1936}, year = {2022}, date = {2022-10-01}, urldate = {2022-10-01}, journal = {European Respiratory Journal}, volume = {61}, issue = {1}, pages = {2200611}, publisher = {European Respiratory Society (ERS)}, abstract = {Background Identifying risk factors for poor outcomes can help with risk stratification and targeting of treatment. Risk factors for mortality and exacerbations have been identified in bronchiectasis but have been almost exclusively studied in European and North American populations. This study investigated the risk factors for poor outcome in a large population of bronchiectasis patients enrolled in India. Methods The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India (EMBARC-India) registry is a prospective observational study of adults with computed tomography-confirmed bronchiectasis enrolled at 31 sites across India. Baseline characteristics of patients were used to investigate associations with key clinical outcomes: mortality, severe exacerbations requiring hospital admission, overall exacerbation frequency and decline in forced expiratory volume in 1 s. Results 1018 patients with at least 12-month follow-up data were enrolled in the follow-up study. Frequent exacerbations (≥3 per year) at baseline were associated with an increased risk of mortality (hazard ratio (HR) 3.23, 95% CI 1.39–7.50), severe exacerbations (HR 2.71, 95% CI 1.92–3.83), future exacerbations (incidence rate ratio (IRR) 3.08, 95% CI 2.36–4.01) and lung function decline. Coexisting COPD, dyspnoea and current cigarette smoking were similarly associated with a worse outcome across all end-points studied. Additional predictors of mortality and severe exacerbations were increasing age and cardiovascular comorbidity. Infection with Gram-negative pathogens (predominantly Klebsiella pneumoniae) was independently associated with increased mortality (HR 3.13, 95% CI 1.62–6.06), while Pseudomonas aeruginosa infection was associated with severe exacerbations (HR 1.41, 95% CI 1.01–1.97) and overall exacerbation rate (IRR 1.47, 95% CI 1.13–1.91). Conclusions This study identifies risk factors for morbidity and mortality among bronchiectasis patients in India. Identification of these risk factors may support treatment approaches optimised to an Asian setting.}, key = {pmid36229049}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Anees_2022, title = {Trace elements in hypothyroidism in relation to L-thyroxine therapy}, author = {Syyeda Anees and Tamkinath Fatima and Shaikh Mahmood}, url = {https://pdf.ipinnovative.com/pdf/17438}, doi = {10.18231/j.ijcbr.2022.050}, issn = {2394-6369}, year = {2022}, date = {2022-09-27}, urldate = {2022-09-27}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {9}, issue = {3}, pages = {260-266}, abstract = {Hypothyroidism is a common disorder in the population with a female predominance. Most hypothyroidism cases were found in the age group range of 30–35 in both the sexes of individuals but women were more prone to develop it. Disturbance or imbalance in the thyroid hormone levels is the underlying cause of resultant hypothyroidism. A comparative study of serum T3 (triiodothyronine), T4 (thyroxine), TSH (thyroid stimulating hormone), copper, zinc, magnesium and iron was done in 100 normal individuals as controls (Group I). 100 Hypothyroid patients showing Good Response to Levothyroxine Therapy – GRLT as (Group II A) and 100 Hypothyroid patients showing Poor Response to Levothyroxine Therapy – PRLT as (Group II B) over a period of 1 and half year in the age group of 20 to 45 years. The levels of TSH were found to be elevated in hypothyroid patients with relatively lower levels of serum T3 and T4 as per our study conducted in hypothyroid patients with PRLT when compared with the healthy subjects and patients in GRLT group. A study of implementation of levothyroxine therapy in hypothyroid subjects showed improvement in the patients with all the hormone levels returning back to the pre – hypothyroid state in majority of the hypothyroid patients with GRLT in comparison with the controls. Results of the study indicate a significant decreased levels of serum copper, zinc and iron in hypothyroid patients showing poor response to levothyroxine therapy whereas the magnesium levels in the serum of hypothyroid individuals with poor response to levothyroxine was found elevated. The serum levels of all the trace elements studied i.e., copper, zinc, magnesium, and iron in GRLT hypothyroid individuals and controls were within the normal ranges. Further studies are however needed on these parameters for establishing serum levels of trace elements in hypothyroidism in relation to response to levothyroxine therapy.}, keywords = {Biochemistry, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Harooni_2022, title = {Mortality prediction score for hirschsprung's disease-associated enterocolitis: a novel mortality prediction model}, author = {Syed Asif Shah Harooni and G. Raghavendra Prasad and Gayatri Reddy Danda and Mahera Naureen}, url = {https://journals.lww.com/jiap/fulltext/2022/27050/mortality_prediction_score_for_hirschsprung_s.16.aspx}, doi = {10.4103/jiaps.jiaps_243_21}, issn = {0971-9261}, year = {2022}, date = {2022-09-09}, urldate = {2022-09-09}, journal = {Journal of Indian Association of Pediatric Surgeons}, volume = {27}, number = {pmid36530801}, issue = {5}, pages = {594-599}, abstract = {Introduction: Enterocolitis associated with Hirschsprung's disease is a fatal and serious complication. Number of scoring systems are in vogue to grade the severity of Hirschsprung's disease associated with enterocolitis (HDAEC), but none of these scoring systems help predict mortality. Hence, we attempt to develop a mortality prediction model (MPM) for HDAEC. Materials and Methods: A retrospective analysis of all cases of HDAEC encountered was analyzed. We also used the parameters of Elhalaby et al. for data collection. A total number of 71 cases were analyzed with regard to mortality in relation to each parameter. Sensitivity and specificity were calculated by statistician, and based on these values, a scoring model was proposed. All those with predicted mortality were given score 2 and those who did not were given score 1. Results: A total score of more than 16 predicted mortality, a score of <10 predicted survival, and a score between 11 and 15 predicted survival with morbidity. Conclusion: A MPM for HDAEC is being proposed.}, keywords = {General Surgery, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Zaffer_2022, title = {Efficacy of gabapentin vs oxcarbazepine in terms of pain, sleep and quality of life in patients with diabetic peripheral neuropathy}, author = {Wadha Nawal Zaffer and Faiz Unnisa and Farath Unnisa and Ayesha Tahoora Fatima and Azmath Unnisa Begum and Mohammed Zoheb}, url = {https://rjn.com.ro/articles/2022.3/RJN_2022_3_Art-08.pdf}, doi = {10.37897/rjn.2022.3.8}, issn = {1843-8148}, year = {2022}, date = {2022-09-01}, urldate = {2022-09-01}, journal = {Romanian Journal of Neurology}, volume = {21}, issue = {3}, pages = {242-247}, publisher = {AMALTEA Medical Publishing House}, abstract = {Background. The treatment of peripheral diabetic neuropathy is difficult to treat considering the pain is severe, long-lasting and does not respond to analgesics. Gabapentin has been recommended as the first line treatment for DPN but owing to cognitive dysfunction and other side effects the drug is discontinued. Recent studies suggest that oxcarbazepine; an antiepileptic drug has good-efficacy in management of DPN. This prospective, observational and comparative study was done to compare gabapentin and oxcarbazepine monotherapy in patient of DPN. Objectives. We assessed the efficacy of Oxcarbazepine monotherapy in terms of pain score, sleep score and quality of life and compared with gabapentin monotherapy. Methods. 100 patients with DPN or examinations suggesting DPN were divided into 2 groups to receive gabapentin 300-1200 mg/day or Oxcarbazepine 300-600mg/day. Assessment of pain scores, sleep score and quality of life were done at different duration during the course of therapy. Results. Out of total subject selected, the maximum (46%) subjects were between age group 60-90 years and the least effected were (24%) between age group 50-59 years. Male were more prevalent with 57% when compared to females with 43%. Improvement in Sleep was seen on using Group II with p value (0.0005). However, the correlation of Pain and Quality of life with the treatment shows p –value 0.24, 0.31 and 0.27 respectively showing non-significance. Conclusion. The sleep improved statistically correlated in patients with DPN, but not with quality of life and pain as the calculated p value was (p= 0.24, 0.31 and 0.27) respectively. Findings of this study suggest that oxcarbazepine can be used as an alternative treatment owing to its similar analgesic efficacy and improvement in sleep.}, keywords = {Deccan School of Pharmacy, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Samee_2022, title = {A study on clinical and microbial culture analysis in diabetic foot disease}, author = {Atif Abdul Samee and Mohammed Abdul Hadi and Syeda Hafsa Rumaan}, url = {http://jcdronline.org/index.php/JCDR/article/view/7238}, doi = {10.31838/jc9r.2022.13.08.236}, issn = {0975-3583}, year = {2022}, date = {2022-08-31}, urldate = {2022-08-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {13}, issue = {8}, pages = {1891-1900}, abstract = {Background:To study the graphic includes of diabetic foot disease in relation with age, sex and blood glucose levels of diabetic patients at Owaisi Hospital & Research Centre. Material and Methods:The present study is descriptive and cross-sectional study of diabetic patients with the diabetic foot lesions (Ulcer, cellulitis or osteomyelitis) of the patients or in patients of Medicine, Surgery and Orthopaedic departments at Owaisi Hospital & Research Centre. The Sample study was done at the Department of Microbiology, here at Deccan College of Medical Sciences from 1st October 2021 to 30th September 2022. Results:A total of 76 microbes were isolated from 30 samples of pus and other executes. It was seen that seen that there was high prevalence of infection males then in females. Almost all the cases studied showed high incidence of uncontrolled diabetes with blood glucose levels higher than 200 mg/dl. Age group affected was studied and it was found that the cases with age group of 65-75 years were highest affected (40%). Majority of samples collected were polymicrobial (nos .22-73.33%) and some also showed more than the microbes, the others were monomicrobial (nos 6-20%) and only two (6.67%) of the samples showed no growth for microbes. Aerobic bacteria showed prevalence in the sample collected (nos 54-71.05%) anaerobic bacteria were 22(28.95%) in number. A total of 29 cocci and 47 bacilli were isolated. Gram –straining showed that there was prevalence of gram-positive bacteria (nos.39) then gram negative was 37 in number. Conclusion:Majority of diabetic foot ulcers were in farmers and people of other slums. These people of the slums showed diabetic foot ulcerations predominantly due to Trauma despite the fact that on the other hand the people of privileged class showed DFU’s due to High incidence of uncontrolled diabetes with blood glucose levels higher than 200 mg/dl. Gram – straining showed that there was high prevalence of gram-positive bacteria than gram negative bacteria.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Raheem_2022b, title = {Role of neutrophil-lymphocyte ratio as a predictive marker in the diagnosis of acute coronary syndrome}, author = {Mariyah Raheem and Asiya Tabassum and Atiya Begum}, url = {https://www.ijsr.net/getabstract.php?paperid=SR22728102305}, issn = {2319-7064}, year = {2022}, date = {2022-08-31}, urldate = {2022-08-31}, journal = {International Journal of Science and Research}, volume = {11}, issue = {8}, pages = {257-261}, abstract = {Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight femalepreponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if P<0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Lamis_2022, title = {Hutchinson-Gilford Progeria syndrome: a literature review}, author = {Aselah Lamis and Shiza W. Siddiqui and Tejaswini Ashok and Nassar Patni and Mahejabeen Fatima and Asiff Nathi Aneef}, url = {https://www.cureus.com/articles/101764-hutchinson-gilford-progeria-syndrome-a-literature-review#!/}, doi = {10.7759/cureus.28629}, issn = {2168-8184}, year = {2022}, date = {2022-08-31}, urldate = {2022-08-01}, journal = {Cureus}, volume = {14}, issue = {2}, pages = {e28629}, publisher = {Cureus, Inc.}, abstract = {Hutchinson-Gilford Progeria syndrome (HGPS) is a premature aging condition that involves genetic mutations, resulting in debilitating phenotypic features. The present state of knowledge on the molecular pathways that contribute to the pathophysiology of HGPS and the techniques being tested in vitro and in vivo to combat progerin toxicity have been discussed here. Nuclear morphological abnormalities, dysregulated gene expression, DNA repair deficiencies, telomere shortening, and genomic instability are all caused by progerin accumulation, all of which impair cellular proliferative capability. In addition, HGPS cells and preclinical animal models have revealed new information about the disease's molecular and cellular pathways and putative mechanisms involved in normal aging. This article has discussed the understanding of the molecular pathways by which progerin expression leads to HGPS and how the advanced therapy options for HGPS patients can help us understand and treat the condition.}, key = {pmid36196312}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2022c, title = {Role of cell-free DNA for predicting incidence and outcome of patients with ischemic stroke}, author = {Nusrath Fathima and Sandhya Manorenj and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan}, url = {https://f6publishing.blob.core.windows.net/0bb64623-48a1-4d1c-9e53-15650da40f4a/WJN-8-1.pdf}, doi = {10.5316/wjn.v8.i1.1}, issn = {2218-6212}, year = {2022}, date = {2022-08-30}, urldate = {2022-08-01}, journal = {World Journal of Neurology}, volume = {8}, issue = {1}, pages = {1-9}, publisher = {Baishideng Publishing Group Inc.}, abstract = {Early diagnosis and prognosis of ischemic stroke remains a critical challenge in clinical settings. A blood biomarker can be a promising quantitative tool to represent the clinical manifestations in ischemic stroke. Cell-free DNA (cfDNA) has recently turned out to be a popular circulating biomarker due to its potential relevance for diagnostic applications in a variety of disorders. Despite bright outlook of cfDNA in clinical applications, very less is known about its origin, composition, or function. Several recent studies have identified cell-derived mitochondrial components including mitochondrial DNA (mtDNA) in the extracellular spaces including blood and cerebrospinal fluid. However, the time course of alterations in plasma mtDNA concentrations in patients after an ischemic stroke is poorly understood. DNA is thought to be freed into the plasma shortly after the commencement of an ischemic stroke and then gradually decreased. However, the importance of cell-free mtDNA (cf-mtDNA) in ischemic stroke is still unknown. This review summarizes about the utility of biomarkers which has been standardized in clinical settings and role of cfDNA including cf-mtDNA as a non-invasive potential biomarker of ischemic stroke.}, keywords = {Central Research Laboratory, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Mir_2022, title = {A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus}, author = {Ali Mir and Abdulaziz Alghamdi and Wajd Alotaibi and Daniya Samreen and Manar Alotaibi and Raidah Albaradie and Shahid Bashir}, url = {https://onlinelibrary.wiley.com/doi/10.1684/epd.2022.1439}, doi = {10.1684/epd.2022.1439}, issn = {1950-6945}, year = {2022}, date = {2022-08-25}, urldate = {2022-08-25}, journal = {Epileptic Disorders}, volume = {24}, issue = {4}, pages = {633-646}, publisher = {Wiley}, abstract = {Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME). However, symptomatic myoclonus which is stimulus-sensitive and provoked by movement is typically seen in PME and Lance-Adams syndrome. Symptomatic myoclonus is not always associated with epileptiform discharges on the electroencephalogram. Therapeutic interventions such as anti-seizure medications (ASMs), the ketogenic diet and vagus nerve stimulation are not always effective. There is emerging evidence that perampanel (PER), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, may be effective for the treatment of myoclonic seizures and symptomatic myoclonus. We performed a systematic review of the literature to assess the efficacy of PER as treatment for myoclonic seizures and symptomatic myoclonus. Twenty-seven studies with a total sample size of 260 patients were included. The efficacy of PER was analysed separately for myoclonic seizures and symptomatic myoclonus. In the group with myoclonic seizures, 50% responder, 75% responder and seizure freedom rates were reported as 74.3% (101/136), 60.3% (82/136) and 57.4% (78/136), respectively, with a follow-up duration of 6–12 months. However, in one post-hoc analysis of data from patients with IGE, the efficacy of PER as treatment for myoclonic seizures during the double-blind phase showed no significant difference compared to placebo. The efficacy of PER for symptomatic myoclonus was reported in a total of 119 patients. Four studies (n=88 patients) reported the efficacy of PER as a decrease in myoclonus score/scale. In the remaining 31 patients, symptomatic myoclonus resolved in three patients, decreased in 21 patients and seven patients showed no improvement. We also analysed the number of patients who were already on levetiracetam (LEV) or valproic acid (VPA) at the time of PER initiation; these data were available for 153 patients. Of these, 56.8% were on LEV and 75.1% were on VPA when PER was initiated. This systematic review suggests that PER may be effective as treatment for drug-resistant myoclonic seizures and symptomatic myoclonus. It may also be effective in patients who have already failed to respond to LEV and VPA. These findings are preliminary yet encouraging. This study has several limitations, particularly given the scarcity of high-quality randomized controlled trials and marked heterogeneity regarding the type and results of the studies. Hence, the findings of this review should be viewed with considerable reservation.}, key = {pmid35770766}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ashok_2022c, title = {CT angiographic study on the variations of the hepatic arteries in the living liver donors of the South Indian population}, author = {Panjala Ashok and Gunapriya Raghunath and Vanacharala Anantha Kumari and B. H. Shiny Vinila}, url = {https://www.ijlpr.com/index.php/journal/article/view/1358}, doi = {10.22376/ijpbs/lpr.2022.12.5.L229-236}, issn = {2250-0480}, year = {2022}, date = {2022-08-24}, urldate = {2022-08-24}, journal = {International Journal of Life Science and Pharma Research}, volume = {12}, issue = {5}, pages = {L229-236}, publisher = {International Journal of Pharma and Bio Sciences}, abstract = {Living liver donor transplantation is the last option for the end stage liver diseases. The variations in the hepatic artery of the liver donor may lead to poor outcome, or may end with major post-operative complications such as hepatic artery thrombosis. To prevent the post-operative complications and to increase the success rate of the liver transplant surgeries, CT evaluation of the hepatic arteries is essential. Thus, the present study was aimed to study the variations of the hepatic arteries in the living liver donors. A total of 200 CT angiograms were collected from the department of Radiology from August 2018 to December 2021, and the evaluation was carried out in the Department of Anatomy, Deccan College of Medical Sciences, Hyderabad. All the CT angiograms were studied for the variations of hepatic arterial system, and the observed variations were noted and the incidence was calculated. The normal anatomy was observed in 62.5% liver donors and 37.55% of liver donors showed variations in hepatic arterial pattern. The incidence of the replaced left hepatic retry, replaced right artery, replaced left along with replaced right hepatic artery was observed as 11.5%, 9.5% and 3% respectively. The incidence of left and right accessory hepatic arteries was 7% and 4% respectively and the replaced right hepatic artery with accessory left hepatic artery was observed in 1.5% cases. The variations observed in the hepatic arterial pattern observed in this study could be helpful to the surgeons, while planning and selecting the suitable liver donors and also may minimise the risk and increase the success rate. }, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Maryam_2022, title = {Post-PCI clinical outcomes of reduced dose prasugrel in comparison to clopidogrel }, author = {Maryam and Mohammadi Fizza Khan and Farheen Sultana and Ofia Mushtaq and Marwah Sultana and Rajashekar Reddy Gurrala and Abhishek Golla and Kazi Jawwad Hussain}, url = {https://journalajcr.com/index.php/AJCR/article/view/96/193}, year = {2022}, date = {2022-08-17}, urldate = {2022-08-17}, journal = {Asian Journal of Cardiology Research}, volume = {5}, issue = {1}, pages = {255-265}, abstract = {Introduction: Patients with ACS undergoing PCI with drug-eluting stent (DES), a one-year regimen with Dual Antiplatelet therapy (DAPT) is recommended to avoid thrombotic events in which any of the two-combination therapy comprising of a P2Y12 inhibitor (Clopidogrel or Prasugrel) and thromboxane A2 inhibitor (Aspirin) is given. Objectives: This study highlights the differences between the two DAPT regimens (clopidogrel + aspirin, reduced dose prasugrel + aspirin) for primary bleeding events post PCI within 48-72 hours, and calculates MACE events at (15 days, 3 months, 6 months) post PCI. Methods: It was a single-centered, prospective study done in a teritary care hospital. The study included 100 subjects with ACS who underwent PCI with DES using clopidogrel or reduced dose prasugrel as the antiplatelet agent along with aspirin. All the patients were observed for primary bleeding events post PCI within 48 hours while in-patient. 15 days, 3 months, and 6 months after their discharge, and initiation of DAPT bleeding and ischemic events were observed. Alongside, MACE events and ADRs were observed 6 months duration. Results: There were 50 patients in clopidogrel group and 50 patients in reduced dose Prasugrel group. Mean age of the study population in the clopidogrel group was 60.3000± 6.670 years (mean ± SD). The mean age of the study population in the reduced dose prasugrel group was 60.1600± 8.39913 years (mean ± SD). There were no events as such in the reduced dose prasugrel group whereas, in the clopidogrel group, 1 patient (2.5%) had an In-hospital major bleeding event post PCI. Two patients from the clopidogrel group and four patients from the prasugrel group died and the cause was unascertained. Minor bleeding events were higher in the Reduced dose Prasugrel group when compared to the clopidogrel group within 6 months post PCI. Conclusion: This study suggests that Reduced dose prasugrel is as safe and efficacious as clopidogrel to prevent stent thrombosis and prevent bleeding events in elderly and in patients of weight 50-60 kgs, post- PCI. Hence, reduced dose Prasugrel as well as clopidogrel can be used in routine clinical practice in patients with high bleeding risk post-PCI. However, studies with a larger sample size and study duration are needed to confirm the above findings.}, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2022b, title = {Cell-free mitochondrial DNA quantification in ischemic stroke patients for non-invasive and real-time monitoring of disease status}, author = {Nusrath Fathima and Sandhya Manorenj and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan}, url = {https://f6publishing.blob.core.windows.net/7f307e4a-b015-447a-a322-f1d12b1e8878/WJTM-10-14.pdf}, doi = {10.5528/wjtm.v10.i2.14}, issn = {2220-6132}, year = {2022}, date = {2022-08-06}, urldate = {2022-08-06}, journal = {World Journal of Translational Medicine}, volume = {10}, issue = {2}, pages = {14-28}, publisher = {Baishideng Publishing Group Inc.}, abstract = {BACKGROUND: Acute ischemic stroke (AIS) is one of the major causes of the continuous increasing rate of global mortality due to the lack of timely diagnosis, prognosis, and management. This study provides a primitive platform for non-invasive and cost-effective diagnosis and prognosis of patients with AIS using circulating cell-free mitochondrial DNA (cf-mtDNA) quantification and validation. AIM: To evaluate the role of cf-mtDNA as s non-invasive, and affordable tool for real-time monitoring and prognosticating AIS patients at disease onset and during treatment. METHODS: This study enrolled 88 participants including 44 patients with AIS and 44 healthy controls with almost similar mean age group at stroke onset, and at 24 h and 72 h of treatment. Peripheral blood samples were collected from each study participant and plasma was separated using centrifugation. The cf-mtDNA concentration was quantified using nanodrop reading and validated through real-time quantitative polymerase chain reaction (RT-qPCR) of NADH-ubiquinone oxidoreductase chain 1 (ND1) relative transcript expression levels. RESULTS: Comparative analysis of cf-mtDNA concentration in patients at disease onset showed significantly increased levels compared to control individuals for both nanodrop reading, as well as ND1 relative expression levels (P < 0.0001). Intergroup analysis of cf-mtDNA concentration using nanodrop showed significantly reduced levels in patients at 72 h of treatment compared to onset (P < 0.01). However, RT-qPCR analysis showed a significant reduction at 24 h and 72 h of treatment compared to the disease onset (P < 0.001). The sensitivity and specificity were relatively higher for RT-qPCR than nanodrop-based cf-mtDNA quantification. Correlation analysis of both cf-mtDNA concentration as well as ND1 relative expression with National Institute of Health Stroke Scale score at baseline showed a positive trend. CONCLUSION: In summary, quantitative estimation of highly pure cf-mtDNA provides a simple, highly sensitive and specific, non-invasive, and affordable approach for real-time monitoring and prognosticating AIS patients at onset and during treatment.}, keywords = {Central Research Laboratory, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2022, title = {A clinical study on comparison of dexmedetomidine versus fentanyl as adjuvant to 0.5% bupivacaine in supraclavicular nerve block}, author = {Vijaya Rekha Koti and Asma Idris and Vamshi Bharadwaj}, url = {https://ejmcm.com/uploads/paper/2cc6e54bd2466c5615c82e673505853f.pdf}, issn = {2515-8260}, year = {2022}, date = {2022-07-31}, urldate = {2022-07-31}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {9}, issue = {7}, pages = {2391-2399}, abstract = {Supraclavicular approach of brachial plexus block has been popular technique in delivery of anesthesia in patients undergoing upper limb surgeries. Of various local anesthetics, bupivacaine is used most frequently for brachial plexus block. Any adjuvant to the local anesthetics for brachial plexus block prolongs its analgesic effect. Hence the present study was undertaken to compare the effect of dexmedetomidine and fentanyl as adjuvant to bupivacaine in supraclavicular nerve block for upper limb surgeries. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Vaseem_2022, title = {A cost-effective simulation model for demonstration of parenteral drug administration for undergraduate medical students}, author = {Ayesha Vaseem and Bhavika D. and Mazher Ali}, url = {https://ejmcm.com/uploads/paper/98979ac97c1eab6d97f998fde2ecdf34.pdf}, issn = {2515-8260}, year = {2022}, date = {2022-07-31}, urldate = {2022-07-31}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {9}, issue = {7}, pages = {2400-2411}, abstract = {INTRODUCTION: The curriculum for medical graduates proposed by the MCI, has undergone significant changes. The new curriculum identifies essential skills, describes methods and contexts of teaching, and recognizes standardized measurement of competencies. It focuses on learning critical competencies needed for success in clinical practice and provides standards and a framework for measuring performance. It allows for self, objective, and multi-source assessments with mandates to improve the quality of healthcare and enhance patient safety. OBJECTIVE: To develop a cost-effective upper limb mannequin for training students in the skill of parental injection techniques to be assessed using objective structured practical examination (OSPE). MATERIALS AND METHODS: Cost effective upper limb was prepared for parenteral drug administration. Each student was able to practice individually. A study questionnaire was given covering aspects of Perception and feedback of the students regarding the mannequins. RESULTS: A Huge percentage (96.87%) of students concurred that simulation is a useful learning method. A large percentage of students agreed that it made the topic interesting and provided a semi-realistic experience. Feedback obtained showed that over half of the students agreed that the mannequins were good. CONCLUSION: The simulation technique provided self-learning of a variety of skills with confidence in a safe and controlled environment without fear of harming patients. Students were able to enhance clinical competence by repeatedly doing the procedure & correcting their mistakes. }, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2022, title = {Diet a modifiable risk factor for stroke: linking diet and stroke; an Indian perspective}, author = {Sandhya Manorenj and Reshma Sultana Shaik}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/9907/6077}, doi = {10.18203/2394-6040.ijcmph20221779}, issn = {2394-6032}, year = {2022}, date = {2022-07-31}, urldate = {2022-07-31}, journal = {International Journal of Community Medicine and Public Health}, volume = {9}, issue = {7}, pages = {3040-3045}, abstract = {Stroke is the second leading cause of death and disability worldwide. The incidence of stroke in India has increased to hundred percent in past few decades. It was the Framingham heart study trial in 2001 which has first identified the role of dietary habits for prevention of atherosclerotic cardiovascular disease. Majority of secondary prevention strategies for Ischemic stroke are directed towards pharmacotherapy with antiplatelet and statins, while dietary modifications are not projected. However dietary and lifestyle modification can reduce stroke risk by 60%. Hence Diet and nutrition play an active role in prevention of stroke. This reviewsummarizes the dietary intake, dietary patterns and risk of stroke among Indians and provides clinicians with pragmatic guidance to their management. We searched Pub Med, MEDLINE, for articles about diet and stroke in India published in English till May 2021. Diet plays a major role in pathophysiology of stroke. Modification of dietary pattern is the major non pharmacological treatment for the primary and secondary prevention of stroke. Indian traditional diet should be modified according to dietary pattern followed in each region. As a whole reduction of rice consumption, higher protein consumption and lower fat consumption should be encouraged at macronutrient level, while higher intake of fruits and vegetables are advised at micronutrient level. Dietary guidelines should be customized and tailor made based on the regional customs and annual income in various subsections of the society.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2022d, title = {Psychometric analysis of clinical chronic obstructive pulmonary disease questionnaire and chronic obstructive pulmonary disease assessment test and its correlation with St. George respiratory questionnaire in chronic obstructive pulmonary disease patients}, author = {Syed Aamir Ali and Hajera Saniya and Khaja Naseeruddin and Sabiha Naaz Sana and Talath Fatima and Syed Mahmood Ahmed and M. Aleemuddin Naveed and Ashfaq Hasan and Fahad Abdullah Bin Breik}, url = {https://www.ijrc.in/doi/pdf/10.4103/ijrc.ijrc_12_22}, doi = {10.4103/ijrc.ijrc_12_22}, issn = {2321-4899}, year = {2022}, date = {2022-07-28}, urldate = {2022-07-28}, journal = {Indian Journal of Respiratory Care}, volume = {11}, issue = {3}, pages = {224-229}, publisher = {Jaypee Brothers Medical Publishing}, abstract = {Introduction: Chronic obstructive pulmonary disease (COPD) is a disease of respiratory airflow obstruction. There are > 80 tools to measure various aspects of COPD patients well.being. This study aimed to evaluate the reliability and consistency of CAT and clinical COPD questionnaire (CCQ) and their correlation with St. George respiratory questionnaire (SGRQ). Methods: A prospective observational comparative study was conducted for 6 months in the pulmonology department of a tertiary care hospital. The following questionnaires were employed to evaluate the state of health of COPD patients: modified Medical Research Council (mMRC), COPD assessment test (CAT), CCQ, and SGRQ. Consistency and inter.rater reliability of CAT and CCQ scales was performed by taking into account the scores of four assessors. Results: Of the 52 patients included, 96% were male, and 4% were female. Cronbach's alpha was 0.620 (CAT score) and 0.861 (CCQ score). The percentage of patients with an mMRC scale of grade 0, 1, 2, 3, and 4 was 4%, 23%, 38%, 8%, and 27%, respectively. SGRQ showed a moderate correlation with CCQ (0.621) and CAT (0.652) scores. Conclusion: The psychometric properties of CAT and CCQ were consistent and satisfactory. Reliability and internal consistency of CAT and CCQ were good and can be employed easily for examining the health state of COPD patients.}, keywords = {Deccan School of Pharmacy, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ali_2022c, title = {Role of circulatory miRNA-21 and associated signaling pathways in the pathogenesis of pulmonary fibrosis among individuals recovered after COVID-19 infection}, author = {Mohammad Ali and Fahad Abdullah Bin Breik and M. Aleemuddin Naveed and Syed Mahmood Ahmed and Aleem Ahmed Khan and Ashfaq Hasan}, url = {https://pdf.sciencedirectassets.com/781323/1-s2.0-S2773044122X00041/1-s2.0-S2773044122000675/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEGcaCXVzLWVhc3QtMSJIMEYCIQCNLTCY5QHh729%2BG2Xaqv3bTBFUOHMk82Eq%2Bp1i6VLbIAIhANym1IQWyGD4XVjP3%2FgKtvnRJOwgkjDq%2FxNubGVh%2Fj79KrsFCKD%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQBRoMMDU5MDAzNTQ2ODY1Igz%2BM4uBCgTAQ3JU7ZcqjwVLiA1AbY%2Byn3ZySOe0gti7PFwy1%2F%2F7UivJWb%2FWJQbMs%2BuHW8Yrxfc1DRwVfJ6cpmggYAW06TXwkc8jI9wzKxsJJVCY9%2BRbJhG3NHMZFnssQ6HuQNcX%2BBmYgQ%2B9r%2BZwGSMUl7m8b0PR%2BXSM2OfA1t8CFemWnhXrnOy9lPYfX018%2FKFXKtQ3dAmwEfagfxN5yH8W5SGCbYw%2ByDj%2BQd5YVxjjLfadSLizOmjH7ciUMMjzZ6H96qqRE6OqDoZo0lbBXCN0urSc1YRqBxRIiG4vSzKt1HBH5KDulCrhW31QTUJLcsnHklGzEWXEkxm%2BTOzJrspxin7xXtFg3qiHz%2BiJxAXsQbH1FCV7NF1cgtly38imq7B%2BAF02oSD3jEIFv%2F3wF5oWXG9ELfq%2BwfhKmKn%2BX8UUXo%2FfnkBLxr%2FwA5UvHh3Bu6bkzDIgppR9qJCGYOUEBh4sO3yUuywupKiqsM1sNza%2FgJhtGduXoRTbPiay9CsW2LdGQJjVK5SFtH%2BiEfcwI0GK1pegr6ME49Xn0ydsfEDIqnugHFBcaebGomgvmY5fS1XvLKzOSHYo5ojSezrOQ591JWobVpfzkS0%2BhhkIpA%2Bsm0y5%2FlVHeiqLREekO4%2BGN3cIzNrOulX8z4HFK%2BPE0zKw1SoHTKtFQUlZtAJc20LnCaNcq0B3SHvqc7%2FcLl5tJO23HAK%2Fje3tFMBlPIQuR7Gj55XP8r3DQM6hPsSJQioRlMGKMCJ52oQ0PLBrVXv5JbEwJXgIBFgdGp4GV%2FXptoAD66DBrbcwHK30E3s7jef2mApzjsQbmW8d5XpbhqRqiZ%2B67LIERbAeA0cm%2F5xei6DRmQDPw%2BUAbAtFWPbrG4t7IMf0oW8bpcHGZSIKZOfoMNjA1sQGOrAB%2B5%2BJz5QnramdyWFHqNzgOXiiqgFwbXRbB7yuZ5C0GwjrSUQyQwJLWGTnlwEzs1OgfeC%2BfFQmonpl3z2J%2FfTaBB0Pl0209sKs527okVIB37Um5%2FjPe1e56MTRilFw0RU39ZOBLAcZ4w9fLtw8BJ3m7FIAZCDBehveRxSY%2Bf6%2F9YAz%2FlVggmfdB7kJHkY7NdIo5CUteDr%2FfuKhUOkEd2ZfN%2F87FUEwLcfNmqbA4qV0kiA%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20250808T080434Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYW73QDFEQ%2F20250808%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=172e306fa88ffe262b3fd9da2b742c7b1c894bb9009cc93efa3101b8f8ed435c&hash=05c7d51a5bb3489003b4a222d416db72c113b8120f0ce02237900d67562b98dc&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2773044122000675&tid=spdf-2df2c19c-9978-41d5-ad72-b88048476411&sid=2818cc551589454166494ac8a60c07c397b9gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&rh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0c565505005d5e0656&rr=96bd80f40a8f2e9c&cc=in}, doi = {10.1016/j.humgen.2022.201093}, issn = {2773-0441}, year = {2022}, date = {2022-07-28}, urldate = {2022-07-28}, journal = {Human Gene}, volume = {34}, pages = {201093}, publisher = {Elsevier BV}, abstract = {Introduction: Currently pulmonary fibrosis in post-COVID individuals represents a crucial milieu of investigation due to long-term associated complications and worse clinical outcome. Lack of studies in Indian population confers a crucial need for elucidating possible targets and mechanisms to explore better management and outcome. Hence, this study aimed to explore the role of circulating miRNA-21 in patients from South India after COVID-19 recovery, while targeting TGF-β signaling pathway involved in the development of pulmonary fibrosis. Methods: This prospective, single centre, hospital-based study enrolled a total of 50 participants in the age group of 50 to 60 years including 25 non-infected controls and 25 patients who were recovered after 3–6 months of COVID-19 infection and presented radiological pulmonary abnormalities. Quantification of miRNA-21 and selected gene transcripts (TGF-β, Col1A2, Col3A1, and α-SMA) was performed in plasma samples of both patients and controls. Results: Significantly increased expression levels of miRNA-21 was observed in patient samples compared to controls (4.50 ± 1.03 vs 12.60 ± 3.52, p < 0.0001) with 72.10% sensitivity and 80.10% specificity. Further, significantly increased levels of central fibrosis regulatory gene transcript TGF-β (0.56 ± 0.27 vs 1.83 ± 0.98), two crucial collagen transcripts Col1A2 (0.62 ± 0.19 vs 1.56 ± 1.00) and Col3A1 (0.61 ± 0.27 vs 1.54 ± 0.89), and α-SMA (0.46 ± 0.17 vs 1.20 ± 0.78) was observed in patients compared to controls. Western-blot analysis also showed almost similar observations at proteins levels. Conclusion: Circulating miRNA-21 may provide crucial insights for elucidating TGF-β mediated pulmonary remodeling involved in the fibrosis development and achieve better clinical outcome for post-COVID patients after recovery, in real-time with high diagnostic accuracy.}, key = {pmid37521444}, keywords = {Central Research Laboratory, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2022, title = {Anemia and heart failure: a narrative review}, author = {Shiza W. Siddiqui and Tejaswini Ashok and Nassar Patni and Mahejabeen Fatima and Aselah Lamis and Krishna Kishore Anne}, url = {https://www.cureus.com/articles/100886-anemia-and-heart-failure-a-narrative-review#!/}, doi = {10.7759/cureus.27167}, issn = {2168-8184}, year = {2022}, date = {2022-07-23}, urldate = {2022-07-01}, journal = {Cureus}, volume = {14}, issue = {7}, pages = {e27167}, publisher = {Cureus, Inc.}, abstract = {Anemia in heart failure patients is a relatively common finding and has been linked with an increased risk of hospital admissions, morbidities, and significant mortality making its correction a significant factor in improving the quality of life and clinical outcomes in those suffering from it. This review article has discussed the multifactorial pathophysiology, including iron deficiency, longstanding inflammation, abnormal levels of human erythropoietin (Epo), and the abnormal activation of the renin-angiotensin-aldosterone system (RAAS) being the most significant. The diagnostic guidelines as well as research-based management modalities specifically with iron supplements and erythropoietin stimulating agents have also been discussed, although research done in this area has been limited and shown conflicting results.}, key = {pmid36017290}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Uwishema_2022b, title = {Current management of acute ischemic stroke in Africa: a review of the literature}, author = {Olivier Uwishema and Christin Berjaoui and Inês F. Silva Correia and Heeba Anis and Ece Karabulut and Dina Essayli and Melissa Mhanna and Adekunbi Oluyemisi}, url = {https://onlinelibrary.wiley.com/doi/10.1111/ene.15495}, doi = {10.1111/ene.15495}, issn = {1468-1331}, year = {2022}, date = {2022-07-15}, urldate = {2022-07-01}, journal = {European Journal of Neurology}, volume = {29}, issue = {11}, pages = {3460-3465}, publisher = {Wiley}, abstract = {Background and purpose: Acute ischemic stroke is one of the leading causes of disability and mortality globally, with increasing incidence in Africa, as the continent is already burdened with infectious diseases. Rapid diagnosis and efficient treatment are crucial, as even a slight delay in reperfusing the brain significantly affects the recovery outcome. Neuroimaging is vital for optimal care and thrombolytic or endovascular therapy in specialized stroke care units. This review aims to discuss the burden of acute ischemic stroke in Africa and how health care systems have tried to reduce the incidence and improve outcomes for the disease. Methods: Data were collected through the online databases PubMed, Ovid MEDLINE, ScienceDirect, and Embase. All articles related to acute ischemic stroke in Africa were considered. Results: The medical care for acute ischemic stroke in Africa is far from optimal, with little adherence to recommended protocols. There is a lack of public awareness of the disease, imaging infrastructure, personnel, stroke care units, and recovery facilities due to poor funding. Poor knowledge of stroke signs and symptoms results in delay in treatment and poor prognosis. Conclusions: We urge African leaders and private entities to invest in stroke care by building appropriate infrastructures, providing medical equipment, and implementing guidelines and sustainable follow-up systems. Telehealth is a suggested strategy to mitigate the scarcity of health personnel, and international and national efforts to increase treatment affordability should be doubled. Further extensive research on the impact of acute ischemic stroke on the African population is encouraged. }, key = {pmid35837810}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2022, title = {A comprehensive stemness gene expression analysis signifies the role of ABC transporters and molecular chaperons in determining the fate of human neural precursor cells}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Syeda Sumaiya Bibi Fathima and Syed Ameer Basha Paspala and Aleem Ahmed Khan}, url = {https://www.neurologyindia.com/temp/ni7031102-2035976_053919.pdf}, doi = {10.4103/0028-3886.349631}, issn = {0028-3886}, year = {2022}, date = {2022-07-01}, urldate = {2022-07-01}, journal = {Neurology India}, volume = {70}, issue = {3}, pages = {1102-1111}, publisher = {Medknow}, abstract = {Background and Aim: The major aim of this study was to identify the most common stemness genes across different stem cell types and further validate them in human fetal subventricular zone-derived primary and cultured neural precursor cells (NPCs). This study involved the use of a unique method of stemness meta-analysis (SMA) for investigating comprehensive upregulation and downregulation of differentially expressed genes (DEGs) among different stem cell populations. Materials and Methods: A total of 55 mouse and human data sets targeting crucial genes identified in seven different types of stem cells population were screened and subjected to independent DEGs analysis using SMA. Identified 30 meta-gene signatures were subjected to functional enrichment analysis based on their biological processes and molecular functions. Validation of enriched meta-gene signatures was performed using RT-qPCR. Cellular localization of ABCB1 and ABCG2 was identified using immunofluorescence staining, whereas functional assessment was performed using western-blot. Results: SMA analysis revealed that among 52 commonly expressed genes, 30 genes were either upregulated or downregulated in at least two stem cell populations. Further gene enrichment analysis showed nine genes (ABCB1, ABCG2, HSPA4, HSPA9, HSPA14, Nestin, Sox-2, Oct-4, and Notch-2) with the highest combined scores among 30 meta-gene signatures. RT-qPCR demonstrated that all the enriched gene signatures were significantly upregulated in primary NPCs and further downregulated during NPCs lineage differentiation in culture except HSPA4, HSPA9, and HSPA14 gene transcripts. Conclusions: The stemness meta-gene signatures were abundantly expressed in human NPCs population which categorically suggest the involvement of these genes/pathways in pluripotency maintenance and molecular switches for lineage differentiation while HSP-70 had a neuroprotective effect.}, key = {pmid35864646}, keywords = {Central Research Laboratory, Medical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Ashok_2022, title = {Celiac disease and autoimmune thyroid disease: the two peas in a pod}, author = {Tejaswini Ashok and Nassar Patni and Mahejabeen Fatima and Aselah Lamis and Shiza W. Siddiqui}, url = {https://www.cureus.com/articles/101467-celiac-disease-and-autoimmune-thyroid-disease-the-two-peas-in-a-pod#!/}, doi = {10.7759/cureus.26243}, issn = {2168-8184}, year = {2022}, date = {2022-06-23}, urldate = {2022-06-23}, journal = {Cureus}, volume = {14}, issue = {6}, pages = {e26243}, publisher = {Cureus, Inc.}, abstract = {Celiac disease (CD) is a small intestinal inflammatory disease commonly seen in the Western population. It has been observed that patients with monoglandular and polyglandular autoimmunity have a higher prevalence of celiac disease. Hashimoto's thyroiditis (HT) and Graves' disease (GD), which mainly constitute the autoimmune thyroid diseases (AITD), characterized by lymphocytic infiltration of the thyroid parenchyma, are noted to be frequently associated with celiac disease. The fundamental mechanism of this frequent coexistence is thought to be a shared genetic background. Due to the subclinical nature of the celiac disease, the diagnosis is often missed or made coincidentally during screening. The rising prevalence of the celiac disease among AITD patients has urged researchers to investigate the link between the two. We reviewed the most recent and relevant literature on the intriguing relationship between celiac disease and thyroid autoimmunity. The objectives of this article were to study the shared genetic background, the incidence of CD in AITD, the effect of a gluten-free diet on AITD, and the need for routine screening of CD in AITD patients.}, key = {pmid35911325}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2022b, title = {Therapeutic role of vitamin D in multiple sclerosis: an essentially contested concept}, author = {Mahejabeen Fatima and Aselah Lamis and Shiza W. Siddiqui and Tejaswini Ashok and Nassar Patni and Olatunji E. Fadiora}, url = {https://www.cureus.com/articles/99491-therapeutic-role-of-vitamin-d-in-multiple-sclerosis-an-essentially-contested-concept#!/}, doi = {10.7759/cureus.26186}, issn = {2168-8184}, year = {2022}, date = {2022-06-22}, urldate = {2022-06-01}, journal = {Cureus}, volume = {14}, issue = {6}, pages = {e26186}, publisher = {Cureus, Inc.}, abstract = {Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system with incredibly intricate etiopathogenesis involving numerous genetic, epigenetic, and environmental risk factors. Major environmental risk factors include ultraviolet (UV) radiation, vitamin D, Epstein-Barr virus (EBV) infection, smoking, and high body mass index (BMI). Vitamin D, in particular, can be viewed as one piece of this puzzle, with various tabs and pockets, occupying a sequential site. In this article, we have briefly discussed the neuroimmunology of MS and the role of vitamin D in regulating immune responses. Various observational studies and clinical trials were reviewed and discussed according to stages of disease activity and course of the disease. The data reviewed in this article implied that serum vitamin D levels greatly influence the risk of developing MS and disease activity. Long-term follow-up studies indicated that low serum vitamin D levels correlate with worse disability outcomes. Since clinical trials did not provide significant evidence, the role of vitamin D in controlling disease activity remains unresolved. Larger clinical trials are needed to support the findings of observational studies and provide significant evidence in favour of vitamin D.}, key = {pmid35911285}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Patni_2022b, title = {Magnesium and hypertension: decoding novel anti-hypertensives}, author = {Nassar Patni and Mahejabeen Fatima and Aselah Lamis and Shiza W. Siddiqui and Tejaswini Ashok and Ahmad Muhammad}, url = {https://www.cureus.com/articles/96710-magnesium-and-hypertension-decoding-novel-anti-hypertensives#!/}, doi = {10.7759/cureus.25839}, issn = {2168-8184}, year = {2022}, date = {2022-06-10}, urldate = {2022-06-01}, journal = {Cureus}, volume = {14}, issue = {6}, pages = {e25839}, publisher = {Cureus, Inc.}, abstract = {Hypertension (HTN) is a complex multifactorial disease that is one of the most prevalent disorders in our modern world. It can lead to fatal complications like coronary artery disease (CAD) and congestive heart failure (CHF) in high-risk individuals. The silent nature of HTN also contributes to its immense caseload and, today, with a number of combinations and various antihypertensive agents, patient compliance is becoming increasingly difficult. This article has reviewed the role and mechanisms of magnesium (Mg) in reducing HTN in the human body so as to provide more information that may help include it as a mainstream antihypertensive regimen. This review has also shed light on the cardioprotective nature of Mg against pathologies like CHF with special mention to patient groups who are at high risk for low Mg levels. Many studies included in this article solidify the former link, but some also provide contradicting data.}, key = {pmid35836446}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Patni_2022, title = {Magnesium and hypertension: decoding novel anti-hypertensives}, author = {Nassar Patni and Mahejabeen Fatima and Aselah Lamis and Shiza W. Siddiqui and Tejaswini Ashok and Ahmad Muhammad}, url = {https://www.cureus.com/articles/96710-magnesium-and-hypertension-decoding-novel-anti-hypertensives#!/}, doi = {10.7759/cureus.25839}, year = {2022}, date = {2022-06-01}, journal = {Cureus}, publisher = {Cureus, Inc.}, keywords = {}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2022, title = {Therapeutic role of vitamin D in multiple sclerosis: an essentially contested concept}, author = {Mahejabeen Fatima and Aselah Lamis and Shiza W. Siddiqui and Tejaswini Ashok and Nassar Patni and Olatunji E. Fadiora}, url = {https://www.cureus.com/articles/99491-therapeutic-role-of-vitamin-d-in-multiple-sclerosis-an-essentially-contested-concept#!/}, doi = {10.7759/cureus.26186}, year = {2022}, date = {2022-06-01}, journal = {Cureus}, publisher = {Cureus, Inc.}, keywords = {}, pubstate = {published}, tppubtype = {article} } @article{Tabassum_2022b, title = {Covid-19 vs dengue-role of WBC counts in segregation of cases at an early stage with special reference to NLR as a diagnostic and prognostic factor}, author = {Asiya Tabassum and Idrees Akhtar Afroze and Sumayya Begum }, url = {https://www.ijmsir.com/asset/images/uploads/16560077756647.pdf}, issn = {2458-868X}, year = {2022}, date = {2022-05-31}, urldate = {2022-05-31}, journal = {International Journal of Medical Science and Innovative Research}, volume = {7}, issue = {3}, pages = {155-162}, abstract = {Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the initial stages but have different clinical management which makes it challenging for the health care professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done decreasing the mortality and for better outcome of these patients. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2022, title = {Dyslipidemia in chronic renal failure and its implications in associated cardiovascular disease}, author = {Kazi Jawwad Hussain and Kazi Wajid Hussain and Kazi Arshad Hussain and Mohammed Khaleel Ahmed}, url = {http://jcdronline.org/admin/Uploads/Files/62df67468a9986.05887830.pdf}, issn = {0975-3583}, year = {2022}, date = {2022-05-30}, urldate = {2022-05-30}, journal = {Journal of Cardiovascular Disease Research}, volume = {13}, issue = {5}, pages = {1439-1448}, abstract = {Background & Objectives:Lipid disorders are one of the known metabolic changes associated with chronic renal failure (CRF) The prominent features of uremic dyslipidemia are an increase in plasma triglyceridesand cholesterol in nearly all lipoproteins, and a reduction in high-density lipoprotein (HDL) cholesterol. Cardiovascular disease (CVD) is a major cause of mortality in patients with chronic renal failure (CRF). One of the risk factors for cardiovascular disease is dyslipidemia as it accelerates atherosclerosis. Therefore it is essential to study uremic dyslipidemia, since optimal treatment is essential for the prevention or delay of cardiovascular complications in patients with CRF. Methods :Plasma lipid profile was studied in 30 patients of non diabetic chronic renal failure, 17 non-dialysed patient, 13 hemodialysis patients and compared to 25 healthy subjects. LDL was calculated using friedwald’s formula. Results :Plasma triglycerides (174±60.7 mg/dl Vs 97±17 mg/dl) and VLDL fraction (34.88±12.15 mg/dl Vs 19.3±3.49 mg/dl) were significantly elevated in CRF patients compared to controls (p < 0.001). There was significant decrease in plasma HDL (36±5.1 Vs 48.8±10.3) in CRF patients compared to controls (p < 0.001). There was no significant difference in total cholesterol (187±43.5 Vs 185.2±24.51 mg/dl) in CRF and Controls (p >0.05). On comparing lipid profiles in CRF patients on conservative management and Hemodialysis there was significant increase in triglycerides in hemodialyis group (199.01±70 Vs 155.176±47mg/dl). Conclusion:Uremic dyslipidemia is a specific Metabolic abnormality. Excess triglycerides and VLDL fraction was observed in patients of CRF both on conservative management and hemodialysis. Further, reduced level of HDL cholesterol was also observed both in conservative and hemodialysis group of CRF patients. Dyslipidemia observed in Uremic patients may contribute to accelerated atherosclerosis and further progression of chronic renal failure.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2022b, title = {Incidence and outcome of contrast induced nephropathy in diabetic hypertensive patients with stage 1 to stage 3 CKD undergoing coronary/peripheral interventions as detected by eGFR and serum creatinine}, author = {Kazi Jawwad Hussain and Kazi Wajid Hussain and Kazi Arshad Hussain and Abhishek Golla}, url = {http://jcdronline.org/admin/Uploads/Files/62f7757f1a7db0.85049614.pdf}, issn = {0975-3583}, year = {2022}, date = {2022-05-30}, urldate = {2022-05-30}, journal = {Journal of Cardiovascular Disease Research}, volume = {13}, issue = {5}, pages = {2116-2126}, abstract = {Background & Objectives: Contrast-induced nephropathy is a leading cause of morbidity and mortality in high-risk patients undergoing any cardiac catheterisation especially among diabetic hypertensive patients with near normal creatinine. There have been many studies previously in diabetic patients developing CIN however not many studies have addressed the incidence and clinical predictors in combined hypertensive diabetics. The need for this study is to identify the incidence of contrast induced nephropathy, among diabetic hypertensive patients with normal serum creatinine and stage 1 to stage 3 CKD as assessed by eGFR undergoing cardiac catheterization. Materials & Methods: The study was carried out in the Department of Cardiology, Sri Jayadeva Institute of Cardiology, Bengluru.The study included patients like diabetic and hypertensive who are undergoing coronary/peripheral catheterisation attending the Department of Cardiology, Sri Jayadeva Institute of Cardiology, Bengluru during the period of February 2016 to July 2017 (18 months study).Serum Creatinine was collected by pre and post catheterization in patients with diabetes undergoing cardiac catheterization and six months post procedure. Other variables were also calculated like hemoglobin, blood sugar and HbA1c,LVEF. Results: Among 140 patients 26(18.57%) patients developed CIN and 114 (81.43%) did not develop CIN. Diabetic patients had significantly higher incidence of CIN (p value 0.013). Incidence of CIN in hypertensive patients was (15.8%) which was statistically insignificant. Patient with CKD as determined by eGFR <60 ml/min/1.73m2 had significantly higher incidence of CIN (p value 0.039). Mean serum creatinine values pre,post and follow up after 6 months were 0.868, 0.956 and 0.962 mg/dl respectively (p value <0.001). Mean eGFR values pre,post and follow up after 6 months were 100.39, 90.74 89.57 ml/mim/1.73m2 respectively (p value <0.001) .Mean Hb values pre,post and follow up after 6 months were 14.12 ,13.30 and 13.9 gm/dl respectively (p value <0.001) Conclusion: CIN is an iatrogenic disorder, resulting from the administration of Contrast media. Periprocedural blood loss, tachycardia, eGFR<60,low ejection fraction, diabetes, greater amount of contrast medium, and higher number of stents are important factors correlating with CIN. These risk factors are synergistic in their ability to predispose to the development of CIN. A careful risk–benefit analysis must always be performed prior to the administration of CM to patients at risk for CIN. Perhaps the most beneficial, and easily applicable, intervention is minimizing the amount of radio contrast dye used during the case.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Shamshuddeen_2022, title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas}, author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze}, url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841}, doi = {10.53730/ijhs.v6ns3.7623}, issn = {2550-696X}, year = {2022}, date = {2022-05-20}, urldate = {2022-05-20}, journal = {International Journal of Health Sciences}, volume = {6}, issue = {S3}, pages = {6963-6971}, publisher = {Universidad Tecnica de Manabi}, abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2022, title = {Acute pancreatitis: an unusual extrapulmonary manifestation of Mycoplasma pneumoniae}, author = {Hina Ramsha Alfia Khan and Avtar Singh and Omer Usman and Samir Rafiq and Anam Amin}, url = {https://www.cureus.com/articles/92654-acute-pancreatitis-an-unusual-extrapulmonary-manifestation-of-mycoplasma-pneumoniae#!/}, doi = {10.7759/cureus.25052}, issn = {2168-8184}, year = {2022}, date = {2022-05-16}, urldate = {2022-05-01}, journal = {Cureus}, volume = {14}, issue = {5}, pages = {e25052}, publisher = {Cureus, Inc.}, abstract = {Mycoplasma pneumoniae is a respiratory pathogen responsible for community-acquired atypical pneumonia. Apart from respiratory manifestations, other system involvement has also been reported. We present a case of interstitial pneumonia and a concurrent episode of acute pancreatitis in a young female who presented with fever, cough, vomiting, and epigastric pain. The abdominal evaluation revealed epigastric tenderness with no signs of organomegaly. Her complete metabolic profile was nonsignificant except for elevated serum lipase and amylase. Clinical, serological, and radiological features and detailed investigations confirmed the diagnosis of acute pancreatitis and interstitial pneumonia caused by M. pneumoniae in the absence of any other etiology. Her respiratory and gastrointestinal symptoms improved rapidly after commencing clarithromycin, providing a possible link between M. pneumoniae and pancreatitis.}, key = {pmid35719829}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Garcia_2022, title = {An artificial intelligence system applied to recurrent cytogenetic aberrations and genetic progression scores predicts MYC rearrangements in large B-cell lymphoma}, author = {Rolando García and Anas Hussain and Weina Chen and Kathleen Wilson and Prasad Koduru}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/jha2.451}, doi = {10.1002/jha2.451}, issn = {2688-6146}, year = {2022}, date = {2022-05-16}, urldate = {2022-05-01}, journal = {eJHaem}, volume = {3}, issue = {3}, pages = {707-721}, publisher = {Wiley}, abstract = {Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma, is characterized by MYC rearrangements (MYC R) in up to 15% of cases, and these have unfavorable prognosis. Due to cryptic rearrangements and variations in MYC breakpoints, MYC R may be undetectable by conventional methods in up to 10%–15% of cases. In this study, a retrospective proof of concept study, we sought to identify recurrent cytogenetic aberrations (RCAs), generate genetic progression scores (GP) from RCAs and apply these to an artificial intelligence (AI) algorithm to predict MYC status in the karyotypes of published cases. The developed AI algorithm is validated for its performance on our institutional cases. In addition, cytogenetic evolution pattern and clinical impact of RCAs was performed. Chromosome losses were associated with MYC-, while partial gain of chromosome 1 was significant in MYC R tumors. MYC R was the sole driver alteration in MYC-rearranged tumors, and evolution patterns revealed RCAs associated with gene expression signatures. A higher GPS value was associated with MYC R tumors. A subsequent AI algorithm (composed of RCAs + GPS) obtained a sensitivity of 91.4 and specificity of 93.8 at predicting MYC R. Analysis of an additional 59 institutional cases with the AI algorithm showed a sensitivity and specificity of 100% and 87% each with positive predictive value of 92%, and a negative predictive value of 100%. Cases with a MYC R showed a shorter survival.}, key = {pmid36051032}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Shamshuddeen_2022b, title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas}, author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze}, url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841}, doi = {10.53730/ijhs.v6nS3.7623 }, issn = {2550-696X}, year = {2022}, date = {2022-05-09}, urldate = {2022-05-09}, journal = {International Journal of Health Sciences}, volume = {6}, issue = {S3}, pages = {6963-6971}, abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2022, title = {Association of angiotensin II type 1 receptor (AT1R) gene polymorphism with angiotensin II serum levels in patients with essential hypertension}, author = {M. Prasad and D. Rajarajeswari and K. Ramlingam and R. Viswakumar and B. Suneel and Jyothi Conjeevaram and P. Aruna and Nusrath Fathima and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan}, url = {https://link.springer.com/article/10.1007/s12291-022-01041-z}, doi = {10.1007/s12291-022-01041-z}, issn = {0970-1915}, year = {2022}, date = {2022-04-30}, urldate = {2022-04-30}, journal = {Indian Journal of Clinical Biochemistry}, volume = {38}, issue = {1}, pages = {110-119}, publisher = {Springer Science and Business Media LLC}, abstract = {Essential hypertension (EH) is a multifactorial, polygenic condition, and is one of the most important comorbidities that contributes to stroke, myocardial infarction, cardiac failure, and renal failure. The continuous increasing rate of morbidity and mortality associated with EH presents an unmet need of population-based studies to explore pathophysiology as well as newer strategies for better diagnosis, prognosis and treatment. This study aimed to determine genotype and allele frequencies of A1166C polymorphism of AT1R gene in Indian patients with EH and correlated with serum levels of Angiotensin II. A total of 200 patients with EH and 200 age- and gender-matched control individuals were included in this study from the General Medicine Department Outpatient at Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India. Patients with systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg were considered as hypertensive. The findings of this study revealed significantly increased risk of C/A heterozygote and allele C in both men and women. Moreover, both men and women patients with EH showed higher serum levels of Angiotensin II with C/A as well as AA genotypes. These findings indicate a significant association of 1166 C/A polymorphism of the AT1R gene with increased risk of hypertension in Indian population.}, key = {pmid36684488}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Zain_2022b, title = {A rare case of Sheehan syndrome with cardiac tamponade}, author = {Ahmer Zain and Ashwin Sivakumar and Ozo Akah and Saher T. Shiza and Ashwini Mahadevaiah and Aadil Khan}, url = {https://www.cureus.com/articles/86926-a-rare-case-of-sheehan-syndrome-with-cardiac-tamponade#!/}, doi = {10.7759/cureus.24329}, isbn = {2168-8184}, year = {2022}, date = {2022-04-20}, urldate = {2022-04-01}, journal = {Cureus}, volume = {14}, issue = {4}, pages = {e24329}, publisher = {Cureus, Inc.}, abstract = {Sheehan syndrome, also called postpartum hypopituitarism, is primarily caused by ischemic necrosis of the pituitary resulting from a complicated pregnancy. As the clinical presentations occur years after the complication, it is difficult to diagnose this condition. In this report, we discuss the case of a 35-year-old female with altered mental status, generalized edema, and loss of appetite. The condition was complicated due to the comorbidities of multiple medical conditions such as massive pericardial effusion and untreated jaundice. Her anorexic condition perfectly masked the malnourished appearance of the patient. After multiple laboratory tests and diagnostic imaging, the empty sella turcica of the patient propounded Sheehan syndrome. Replacement of the deficient hormones improved her condition after two weeks. Patients with complicated pregnancy history should be advised for diagnostic imaging early in life to appropriately manage Sheehan syndrome. A delay in diagnosis can have significant health and financial loss. Hormone replacement therapy is the only viable option as there is no cure to treat necrosed pituitary.}, key = {pmid35607582}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ashraf_2022, title = {Comparative study to evaluate lipid profile in smoking and non-smoking individual at tertiary care centre}, author = {Syed Mustafa Ashraf and Mohammed Mudassir Ali and Mohammed Abdul Rafi and Syeda Asma Gulnaaz}, url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/6002/2199}, doi = {10.53730/ijhs.v6nS2.6002 }, issn = {2550-6978}, year = {2022}, date = {2022-04-13}, urldate = {2022-04-13}, journal = {International Journal of Health Sciences}, volume = {6}, issue = {S2}, pages = {4358-4365}, abstract = {Background: Cigarette smoking, which is considered a major risk factor for atherosclerosis and coronary heart disease, may lead to changes in normal plasma lipid profile. The aim of the study was to evaluate the effect of cigarette smoking on lipid parameters in smokers and non-smokers. Material and Methods: A cross sectional comparative study was carried out in 200 subjects. The subjects were divided into two groups. Group A consisted of 100 smokers and Group B consisted of 100 Non-smokers. After overnight fasting following laboratory investigations were done in all subjects, Serum total cholesterol, Serum high density lipoprotein (HDL), Serum low density lipoprotein (LDL), Serum very low-density lipoprotein (VLDL), Serum triglyceride (TGL), Fasting blood sugar (FBS), Serum Creatinine, Urine for albumin, sugar and microscopic examination and the results of these tests were compared between the two groups.Results: All the values of lipid profile, TC, HDL, LDL, VLDL, TGL, were found to be significantly higher among the smokers compared to the non-smokers. The mean value of HDL was higher in non-smokers when compared to that of smokers and were statistically significant. }, keywords = {General Medicine, Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Advancement of information technology related to medical and health sector}, author = {Tripuresh Pandey and Syyeda Anees and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/advancement-of-information-technology-related-to-medical-and-health-sector/NDE4MTU=/?is=1&b1=&k=}, issn = {2277-8179}, year = {2022}, date = {2022-04-01}, journal = {International Journal of Scientific Research}, volume = {11}, issue = {4}, pages = {42-43}, abstract = {Information technology (IT) related to medical and health sector has vast area of net working. It is very easy to find out the location and land mark of specified and particular names of hospitals in the field of medical and health centers. It is also very easy to find out the total medical and health facilities under one roof, the list of doctors available, the drug available in pharmaceuticals stores, blood available in in the blood banks, three (3) dimensional surgery facility, a deck facility of the patients etc. The Hottes Medical Technologies are related Advance Telemedicine, New Methods of Drug Development, Data Driven Health Care, Nanomedicine, 5G-Enabled Devices, Tricoders, Healthcare’s Digital Assistants, Smarters Pacemakers, A Lab. on a Chip, Wearables with a Purpose, Remote Patients Monstorins, , Artificial Intelligence, Digital Therapeutics, Technology in Mental Health and Internet of Medical and Health Sector.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Husayni_2022, title = {The use of urinary amylase levels in the diagnosis of acute pancreatitis}, author = {Syed Mohammed Sajjad Husayni and Mohammed Naqi Zain and Mohammed Shazad Ahmed}, url = {https://www.ejmcm.com/archives/volume-9/issue-3/4902}, issn = {2515-8260}, year = {2022}, date = {2022-03-31}, urldate = {2022-03-31}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {9}, issue = {3}, pages = {5029-5038}, abstract = {Background:Acute pancreatitis is a relatively common but potentially fatal disease seen in surgical practise. Clinical examination, laboratory investigations, and imaging techniques are used to make a diagnosis of the disease. Patients usually present with severe pain in the epigastric region that radiates to the back. Serum levels of amylase and lipase that are more than three times the normal value usually indicate acute pancreatic inflammation. When clinical and laboratory investigations fail to diagnose the disease despite a strong suspicion of acute pancreatitis, radiological investigations are used to make a diagnosis. Urinary clearance of pancreatic enzymes from the circulation increases in acute pancreatitis. This is a study that will use urinary amylase levels to diagnose acute pancreatitis in a non-invasive manner. Objectives: To diagnose acute pancreatitis using urine amylase levels in conjunction with other specific tests such as serum lipase and abdominal ultrasound, and to demonstrate that urine amylase can be used to diagnose acute pancreatitis. Materials and Methods: It is a case control study with 40 patients diagnosed with acute pancreatitis and 40 patients admitted with other diagnoses. Patients admitted to Princess Esra Hospital between November 2019 and May 2021 were chosen as cases and controls. Serum amylase, serum lipase, and urinary amylase levels were measured in both the case and control groups. After comparing serum amylase, serum lipase, and urinary amylase levels in cases and controls, the sensitivity and specificity of these enzymes were determined.The authors concluded that serum amylase had the highest sensitivity (100 percent) and serum lipase had the highest specificity (100 percent) after analysing serum amylase, serum lipase, and urinary amylase results in both cases and controls (95 percent). Urine amylase's sensitivity and specificity were found to be 98.33% and 95%, respectively. The area under the curve for serum amylase, serum lipase, and urinary amylase was found to be 0.987, 0.995, and 0.935, respectively, using ROC curve analysis. Conclusion: Because serum amylase, serum lipase, and urinary amylase have comparable sensitivity and specificity, as well as comparable areas under the curve on ROC analysis for the diagnosis of acute pancreatitis, the authors conclude that urinary amylase can be used in the diagnosis of acute pancreatitis.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Zain_2022, title = {A study on post operative complications of thyroid surgery}, author = {Mohammed Naqi Zain and Mohammed Shazad Ahmed and Syed Mohammed Sajjad Husayni}, url = {https://ejmcm.com/issue-content/a-study-on-post-operative-complications-of-thyroid-surgery-4889}, issn = {2515-8260}, year = {2022}, date = {2022-03-31}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {9}, issue = {3}, pages = {5039-5047}, abstract = {Background:The postoperative consequences of thyroid surgery have long been recognised by goitre surgeons. These problems may be serious enough to endanger the patient's life or cause physical or physiological limitations. Given the severity of the consequences, they must be kept to a minimum in this age of contemporary surgery. Moreover, for surgery to remain a dominating treatment option for thyroid illness, its complications must be less than other effective treatments. Aim: objectives of this study is to investigate preoperative factors that influence complication rates, complication rates linked with thyroid surgery type, problem types, complication onset time, complication duration, complication management. Materials and Methods: The current study lasted 18 months from January 2019 to July 2020. Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad. The study included a prospective analysis of 80 goitre surgeries. These cases were clinically investigated and recorded using the attached proforma. Results: A study of 80 goitres having surgery(cases that underwent goiter surgery) revealed Thyroid problems affect women more than men. The hospital saw the most patients in their third decade. Multinodular Goitre in Euthyroid Status was the most common clinical diagnosis. The most prevalent histology diagnosis was Nodular Colloid Goitre. Subtotal thyroidectomy was the most common procedure for goitre. Complications after surgery included wound infection. This trial had no fatality and little morbidity. It is possible to do thyroid surgery with little morbidity and mortality for a wide range of thyroid illnesses if done gently with thorough attention to hemostasis and structural features.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2022, title = {A clinical study of obstructive jaundice secondary to choledocholithiasis}, author = {Mohammed Shazad Ahmed and Syed Mohammed Sajjad Husayni and Mohammed Naqi Zain}, url = {https://ejmcm.com/issue-content/a-clinical-study-of-obstructive-jaundice-secondary-to-choledocholithiasis-4891}, issn = {2515-8260}, year = {2022}, date = {2022-03-31}, journal = {European Journal of Molecular & Clinical Medicine}, volume = {9}, issue = {3}, pages = {5048-5054}, abstract = {Background:Humans have long known about jaundice. Obstructive jaundice is common in general surgery. Intrahepatic or extrahepatic blockage can cause obstructive jaundice. Most patients with suspected biliary blockage start with an abdominal ultrasound. This study aims to determine the prevalence of obstructive jaundice owing to choledocholithiasis in my hospital, the role of ultrasound in detecting such cases, and the treatment options available at Princess Esra Hospital Hyderabad. Materials and Methods: Between June 2019 and June 2021, 24 patients with obstructive jaundice due to choledocholithiasis were studied at Princess Esra Hospital in Hyderabad. These patients received surgery. The proforma was used to assess these patients both pre- and post-operatively. Results: Obstructive jaundice due to choledocholithiasis was 0.14 percent in hospitals. The patients were mostly female (16:4).Symptoms presented in decreasing order of frequency. 100% jaundice, 95% abdominal pain, 50% nausea/vomiting, 50% itching (35 percent), Fever with chills and rigours (25%) Steatorrhea (10%) and abdominal mass (5%).Ultrasound showed stones in 16 (80%) and dilated CBD in all 24 (100%) instances (100 percent ). 11 patients had choledocholithiasis. Four instances had choledocholithiasis and cholelithiasis. The investigation found one incidence of choledocholithiasis with CBD stricture. The most common surgical technique was choledochoduodenostomy (50%) followed by choledochotomy with T-tube drainage (40%) One case each of choledocho-jejunostomy and transduodenal sphincter. All twenty instances had cholecystectomy. All cases were monitored for 1-6 months with no complaints. Conclusion:Patients with obstructive jaundice are more susceptible to infections due to impaired liver function. It's also critical to identify specific risk factors in biliary tract surgery patients. Our study shows that ultrasound is the cheapest, safest, and most reliable diagnostic technique for postoperative jaundice. Despite the advent of laparoscopic CBD exploration, open, internal, and external biliary drainage procedures are still used successfully in areas lacking technology and experience.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{AbdurRaheem_2022b, title = {Defining wider indications for stoppa repair other than recurrent hernias}, author = {Juwairiah Abdur Raheem and Suresh Chandra Annu and Rabiya Begum and Hafsa Iqbal and Mohammed Abdul Majid Adil}, url = {assets.cureus.com/uploads/case_report/pdf/90014/20220430-11451-194ai6m.pdf}, doi = {10.7759/cureus.23671}, issn = {2168-8184}, year = {2022}, date = {2022-03-31}, urldate = {2022-03-31}, journal = {Cureus}, volume = {14}, issue = {3}, pages = {e23671}, publisher = {Cureus, Inc.}, abstract = {Managing complex inguinal hernias has been a constant challenge for surgeons and its treatment is not without challenges with the routine current techniques. Complex inguinal hernias especially recurrent have been managed by the Rives-Stoppa technique which is an established suture-less, tension-free, and absolute method of treatment with minimal recurrence rates. Traditionally, this surgical technique is most indicated in recurrent inguinal hernias, but we aim to assess the usefulness of this procedure for the treatment of complex inguinal hernias in individuals presenting for the first time. We report four varied cases of complex inguinal hernias, repaired by the open Rives-Stoppa technique, and discuss its indications, technique of repair, and current status.}, key = {pmid35505699}, keywords = {General Surgery, Surgical Gastroenterology, Urology}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2022, title = {A comparative study on oral iron and intravenous form of iron (FCM) in treatment of moderate anemia during postpartum period}, author = {Surayya Tahseen and Amtul Asra}, url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/file.php?val=a-comparative-study-on-oral-iron-and-intravenous-form-of-ironfcm-in-treatment-of-moderate-anemia-during-postpartrum-period_March_2022_7145603345_9401565.pdf}, doi = {10.36106/gjra}, issn = {2277-8160}, year = {2022}, date = {2022-03-31}, urldate = {2022-03-31}, journal = {Global Journal of Research Analysis}, volume = {11}, issue = {3}, pages = {38-40}, abstract = {Background: Anemia is a major public health problem worldwide. The global prevalence of anemia during pregnancy is estimated by World Health Organization to be 47.4%. According to recent WHO fgures, India is included in the list of countries with high prevalence of anemia in pregnant women (>40%). Prevalence of postpartum Iron Deficiency Anemia is very high in the India, The maternal mortality rates are also significant. Postpartum anemia is observed in up to 27% of women. It is a major contributing factor and indirect cause of maternal death. Materials And Methods: This comparative study was conducted in the department of Obstetrics and Gynaecology, over a period of 18 months after obtaining clearance from Institutional Review Board. Total 100 postnatal women with microcytic hypochromic anemia attending the department will be included in the study .Cases were randomly distributed into two groups consisting of 50 cases each. Results: Among the study population, in group with iron supplementation, 24% had hemoglobin levels between 7.1-7.9 gm%, 22% had hemoglobin levels between 8.0-8.9 gm% and 24% had hemoglobin levels between 9.0-9.9 gm%. The improvement was seen in around 30% of the patients with 14% between 10-10.9 gm% and 16% above 11 gm%. Overall improvement was seen in 30% of the patients. Conclusions: There was significant improvement in the hemoglobin status among both the group. Among the oral iron group, 30% of them improved their status to either mild anemia or normal status. Amog the FCM group, it was 66%.Treatment oral iron or FCM markedly raised the blood hemoglobin levels but FCM was superior to oral iron.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Kadloor_2022, title = {Comparison of clinical outcomes among thrombolyzed and non-thrombolyzed STEMI patients: a single-centre observational study}, author = {Parvaiz Kadloor and Abhishek Golla and Rajashekar Reddy Gurrala}, url = {https://www.msjonline.org/index.php/ijrms/article/view/10461/7054}, doi = {10.18203/2320-6012.ijrms20220975}, issn = {2320-6012}, year = {2022}, date = {2022-03-28}, urldate = {2022-03-01}, journal = {International Journal of Research in Medical Sciences}, volume = {10}, issue = {4}, pages = {845-849}, publisher = {Medip Academy}, abstract = {Background: There is a paucity of data that compare clinical outcomes, especially morbidity and mortality among thrombolyzed and non-thrombolyzed ST-segment elevation myocardial infarction (STEMI) patients in Indian population. Methods: An observational, single-centre study involving 70 patients who were diagnosed with STEMI from February 2014 to June 2015. Patients were thrombolysed after meticulous evaluation of indications for thrombolytic therapy, and later whenever needed they were subjected to revascularization therapy of either percutenous coronary intervention (PCI) or coronary artery bypass graft (CABG). Then, STEMI patients were categorized into thrombolyzed and non-thrombolyzed groups. Mortality and morbidity parameters such as effort tolerance expressed in terms of New York Heart Association (NYHA) functional class and typical anginal chest pain at 1, 6, and 12-month were primary outcomes. Results: Mean age of the cohort was 53.2 years: 48 men and 22 women. Of the total, 58 (82.9%) patients underwent thrombolysis. Mean window period of thrombolysis therapy was 8.1±2.0 hours. Revascularization was required in 80% of cases. At 12-month, STEMI patients who were thrombolyzed had significantly better effort tolerance in terms of NYHA class than those who were non-thrombolyzed (25% versus 13.8%; p<0.005). At 1 and 6-month, STEMI patients who were thrombolyzed had significantly better effort tolerance in terms of typical anginal pain than those who were non-thrombolyzed (1-month, 82.8% versus 58.3%; p<0.005; 6-month, 4.3% versus 0.0%; p<0.005). Conclusions: This study enlightened the effectiveness of thrombolytic therapy together with revascularization (CABG or PCI) in reducing the morbidity rate than revascularization alone.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Humaira_2022, title = {Effect of sodium glucose co-transporter-2 inhibitors in heart failure patients }, author = {Zareen Humaira and Zara Farheen and Ayesha Samreen and Syeda Safoora Marwa and Rajashekar Reddy Gurrala and Mohammed Hidayathulla and Mirza Misba Ali Baig }, url = {https://journalijrrc.com/index.php/AJRCD/article/view/40}, year = {2022}, date = {2022-03-17}, urldate = {2022-03-17}, journal = {Asian Journal of Research in Cardiovascular Diseases }, volume = {4}, issue = {1}, pages = {72-82}, abstract = {Aim: To study the management outcomes of heart failure therapy with SGLT2-inhibitors added to conventional therapy and to compare its effect in diabetic and non- diabetic heart failure patients. Methods: This is a prospective observational study done at the Department of Cardiology of a tertiary care hospital from November 2020 to January 2022. The study included 100 heart failure patients who were divided into two groups based on administration of SGLT2 inhibitors. Group I consists of HF patients without SGLT2i and Group II: HF patients with SGLT2i. Subjective and objective parameters were recorded as well as the management patterns of the patients were recorded during the hospital stay and the outcomes (improvement in NYHA class, rehospitalisation and mortality) were assessed at follow up. Results: Most of the patients included in the study belonged to NYHA class-III. In this study HFrEF was found to be more prevalent in both group I (71.4%) and group II (83.6%). There was a significant difference observed for ejection fraction both in Group-I (36.45 ± 0.6 vs 38.85 ± 0.75) and Group- II (34.3 ± 0..6 vs 39.2 ± 1.01) at admission and after follow up (P=0.001). In our study when the outcomes were compared between group-I and group-II, there was statistical significance observed for the improvement in NYHA class (54.2% vs 61.2%) and decrease in mortality (11.4% vs 4%) was also observed (P=0.01) at the end of 1 year follow up. The effect of SGLT2i on the primary outcome was consistent in patients regardless of the presence or absence of diabetes. Conclusion: Our study highlights that when SGLT2 inhibitors are used for treating HF patients with or without diabetes, they can have a positive impact as they achieve outcomes like improvement in NYHA class, decreased rehospitalisation and reduction in mortality risk. The study also indicates improvement in Left ventricular ejection fraction in case of HFrEF patients. Furthermore, randomization trials are required to determine the efficacy of SGLT2 inhibitors in Indian population to ascertain its association with better outcomes and to further promote its use. }, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @article{Ali_2022e, title = {Asymmetrical septal hypertrophy: a rare case of respiratory distress in an infant of a diabetic mother}, author = {Syed Adnan Ali and C. V. S. Lakshmi and Uppin Narayan Reddy and Hunaina Manfusa }, url = {https://saspublishers.com/media/articles/SJMCR_103_230-232_WjXuEIO.pdf}, doi = {10.36347/sjmcr.2022.v10i03.015}, issn = {2347-6559}, year = {2022}, date = {2022-03-14}, urldate = {2022-03-14}, journal = {Scholars Journal of Medical Case Reports}, volume = {10}, issue = {3}, pages = {230-232}, publisher = {SASPR Edu International Pvt. Ltd}, abstract = {Introduction: Cardiomyopathy is a disease that affects the myocardium and causes mechanical or electric dysfunction. Hypertrophic cardiomyopathy comprises various cardiac components such as thickening of ventricular walls, hypertrophy of inter-ventricular septum thereby resulting in sub-aortic stenosis, systolic and/or diastolic dysfunction. This cardiac complication is a known but rare entity in infants of diabetic mothers wherein the clinical presentation ranges from being asymptomatic to respiratory distress to congestive cardiac failure. The incidence of Congenital Heart Disease in infants of Diabetic Mothers is 5% and the percentage of symptomatic HOCM babies is 12%. Case Report: We report a term neonate, born to a G2P2L2 mother with Gestational Diabetes Mellitus with poor glycemic control, presenting with respiratory distress manifesting as silent tachypnea at 24 hours of life, diagnosed as Asymmetrical Septal Hypertrophy on 2D-Echo, treated successfully with Propranolol and showed resolution of hypertrophy in follow-up echocardiography. Conclusion: Fetal hyperinsulinemia is responsible for the increase in synthesis and deposition of fat and glycogen in the myocardial cells which explains cardiac hypertrophy. Due to an increase in the thickness of the Interventricular Septum, there is Left Ventricular Hypertrophy and during systole, the Systolic Anterior Motion of the anterior leaflet (SAM) of the aortic valve is elongated. Therefore, due to this obstruction of the orifice by the aortic valve, there is a reversal of blood flow clinically manifesting as silent tachypnea. Symptomatic babies are treated with Oral Propranolol which acts by improving left ventricular outflow obstruction.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Sadaf_2022, title = {Role of biochemical markers in rheumatoid arthritis}, author = {Samreen Sadaf and Ruksana Kausar and Syyeda Anees and Shaikh Mahmood}, url = {https://www.ijcbr.in/html-article/16072}, issn = {2394-6369}, year = {2022}, date = {2022-03-11}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {9}, issue = {1}, pages = {86-89}, abstract = {Introduction: Rheumatoid arthritis is the most common chronic, progressive systemic inflammatory arthritis of unknown cause. It affects approximately 1-2% of the population worldwide. It is a form of autoimmune disease principally synovial tissues. As the pathophysiology involves affecting cell mediated immune response, adenosine deaminase may have a role in rheumatoid arthritis. As it involves bones and joints, it is likely that it alters the levels of Serum Calcium, Phosphorus and Magnesium as well as Alkaline Phosphatase which may be helpful in diagnosis or management of the disease. Aims & Objectives: 1. To evaluate the role of serum adenosine deaminase (ADA) as a marker of cell mediated immunity in Rheumatoid Arthritis. 2. To estimate serum alkaline phosphatase, calcium, phosphorus and magnesium as prognostic markers of Rheumatoid arthritis Materials and Methods: A cross-sectional, case control study with convenient sampling was undertaken after Institutional Ethical Clearance & informed consent. 30 patients of Rheumatoid Arthritis presenting to the orthopaedic outpatient department of Owaisi Hospital and Research Centre, Hyderabad were taken as cases along with an equal number of age and sex matched controls from January 2021 to June 2021. ADA levels were estimated by colorimetric assay on ErbaChem 7 semiautoanalyser. Serum Alkaline phosphatase, Calcium, Phosphorus and Magnesium were estimated on Cobas C311 autoanalyzer. Results: There was a significant increase in levels of Adenosine Deaminase, Alkaline Phosphatase and Serum Phosphorus, while the levels of Calcium and Magnesium were significantly reduced in rheumatoid arthritis Conclusion: ADA as a marker of cell mediated immunity reflects monocyte / macrophage activity and was increased in our study suggesting immunological and inflammatory process in the pathogenesis of Rheumatoid Arthritis (R.A). It can be used as a non invasive marker of chronic inflammation and may provide additional information about disease prognosis. Increased levels of Alkaline Phosphatase and Phosphorus associated with low Calcium and Magnesium suggest increased bone resorption in R. A and are useful as markers of disease activity.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Raheem_2022, title = {Dapsone as a detrimental cause of necrotizing fasciitis with severe resistant neutropenia: A case report}, author = {Juwairiah Abdur Raheem and Arshiya Unnisa and Mohammed Asif Muzaffer Iqubal}, url = {https://www.cureus.com/articles/87048-dapsone-as-a-detrimental-cause-of-necrotizing-fasciitis-with-severe-resistant-neutropenia-a-case-report#!/}, doi = {10.7759/cureus.23076}, issn = {2168-8184}, year = {2022}, date = {2022-03-11}, journal = {Cureus}, volume = {14}, issue = {3}, pages = {e23076}, publisher = {Cureus, Inc.}, abstract = {Dapsone, which is used for treating dermatological conditions, can lead to neutropenia. Especially, resistant neutropenia makes patients vulnerable to invasive infections, indicating a medical emergency. Febrile neutropenia secondary to dapsone intake should be treated promptly before the development of sepsis, which may lead to shock and death. In addition, necrotizing fasciitis is a severe and potentially fatal soft-tissue infection that rarely develops in healthy individuals with skin lesions. In this report, we present a case of a patient with no comorbidities who presented with necrotizing fasciitis and neutropenia with a history of dapsone intake.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Sreerambhatla_2022, title = {Contribution of genetic variants of DNA repair genes XRCC1 and APE1 in pediatric patients with food and air born allergen asthma}, author = {Nandita Sreerambhatla and Uppin Narayan Reddy and Shaik Iqbal Ahmed and Nusrath Fathima and Aleem Ahmed Khan}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/contribution-of-genetic-variants-of-dna-repair-genes-xrcc1-and-ape1-in-pediatric-patients-with-food-and-air-born-allergen-asthma_February_2022_8241044964_1206692.pdf}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2022}, date = {2022-02-28}, urldate = {2022-02-28}, journal = {Indian Journal of Applied Research}, volume = {12}, issue = {2}, pages = {45-47}, abstract = {INTRODUCTION: Allergic asthma in children occurs in response to an allergic trigger major. In the pathophysiology of asthma, genetic variations in many loci and genes play a crucial role. Genes of DNA repair pathways have been well characterized in association with clinical pathologies of different forms of allergic asthma with conicting outcomes. This study reports the role of single nucleotide polymorphisms (SNPs) in X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1)polymorphisms in pediatric patients with food and air born allergen asthma. METHODS: 125 pediatric asthma patients and age and gender matched 164 controls were enrolled. Blood samples were collected after conrming the food and air allergen related asthma. Genomic DNA was isolated from whole blood and genotyping was done for XRCC1 Arg399Gln and APE1 Asp148Glu using ARMS-PCR. RESULTS: The frequency of genotype Arg399Gln (heterozygous) of XRCC1 gene was signicantly higher in patients with allergic asthma than the controls (odds ratio [OR] 2.75; 95% condence interval [CI] 1.69 -4.47; p=0.006). 'A' allele of XRCC1 gene was found to be predominant in pediatric asthma group compared to controls. Similarly the genotype TG frequency of APE1 Asp148Glu showed statistically signicant change in allergic asthma patients compare to controls (OR 2.93; 95% CI 1.77-4.85; p<0.001). 'G' allele of APE1 gene was found predominantly in pediatric asthma group compared to controls. CONCLUSION: Polymorphisms in XRCC1 Arg399Gln and APE1 Asp148Glu signicantly increased the risk of allergic asthma in pediatric patients.}, keywords = {Central Research Laboratory, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2022c, title = {A study of origin of coronary arteries in adult heart specimens}, author = {Mohammed Khaleel Ahmed and Zafar Sultana Abdul Saleem}, url = {https://jcdronline.org/admin/Uploads/Files/62d6e1647799c0.40889232.pdf}, issn = {0975-3583}, year = {2022}, date = {2022-02-28}, urldate = {2022-02-28}, journal = {Journal of Cardiovascular Disease Research}, volume = {13}, issue = {2}, pages = {1453-1458}, abstract = {Introduction: Knowledge of the normal and variant anatomy and anomalies of coronary circulation is use to cardiologists and interventional radiologist to predefine the abnormalities by invasive and noninvasive studies.1 , the present work was aimed to study the site of origin and distance from the supravalvular ridge, of right and left coronary arteries. Materials and Methods: 100 normal hearts with age group 20-60 years from nonspecific cadavers were included. The interior of the three sinuses were examined to note the number of Ostia. The ostium diameter of the right and left coronary arteries the relation of the level of the ostium is compared to the level of supravalvular ridge. Results&Discussion: In 82 the specimens the ostium is below the supravalvular ridge and in 4 of the specimens it is at the supravalvular ridge. 14 of the specimens it is above the supravalvular ridge. The left coronary artery ostium is situated in the left posteiro aortic sinus and in 86 of the specimens the ostium is present below the supravalvular ridge and in 6 of the specimens it is situated at the supravalvular ridge.8 of the specimens it is above the supravalvular ridge. Conclusion: The location,number, level of the ostium is very important in the successful performance of coronary angiogram and other invasive, noninvasive procedures and also determine the accurate size of cardiac catheters for interventional cardiology.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{AbdurRaheem_2022, title = {Is abdominal cocoon a sequela in recovered cases of severe COVID-19?}, author = {Juwairiah Abdur Raheem and Suresh Chandra Annu and Lahari Ravula and Sara Samreen and Ariyan Khan}, url = {https://www.cureus.com/articles/86570-is-abdominal-cocoon-a-sequela-in-recovered-cases-of-severe-covid-19#!/}, doi = {10.7759/cureus.22384}, issn = {2168-8184}, year = {2022}, date = {2022-02-19}, urldate = {2022-02-19}, journal = {Cureus}, volume = {14}, issue = {2}, pages = {e22384}, publisher = {Cureus, Inc.}, abstract = {Abdominal cocoon is one of the rare causes of intestinal obstruction mostly diagnosed at the operating table. Its etiology is primarily unknown but can be secondary to known causes. The involvement of the gastrointestinal (GI) system was a common feature during the second wave of COVID-19, and at present, there are reports of GI symptoms in patients who have completely recovered from COVID-19. Abdominal cocoon formation has been reported during the active stage of COVID-19 but not as its sequela. We report two cases with a high degree of suspicion of abdominal cocoon formation in middle-aged individuals with no comorbidities, who recovered from a severe form of COVID-19.}, key = {pmid35371817}, keywords = {General Surgery, Surgical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Uwishema_2022, title = {Neurological disorders in HIV: hope despite challenges}, author = {Olivier Uwishema and Georges Ayoub and Rawa Badri and Helen Onyeaka and Christin Berjaoui and Ece Karabulut and Heeba Anis and Christophe Sammour and Fatima E. A. Mohammed Yagoub and Elie Chalhoub}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.591}, doi = {10.1002/iid3.591}, issn = {2050-4527}, year = {2022}, date = {2022-02-10}, urldate = {2022-02-01}, journal = {Immunity, Inflammation and Disease}, volume = {10}, issue = {3}, pages = {e591}, publisher = {Wiley}, abstract = {Introduction: Human Immunodeficiency virus (HIV) is a virus that causes several diseases by attacking the human immune system. It is transmitted by contact with certain bodily fluids of an infected person, most commonly during unprotected sex, through sharing needles, or from mother to baby during pregnancy, birth or breastfeeding. The central nervous system is not spared from this virus, as HIV has been shown to induce several neurological disorders. However most neurological pathologies (such as dementia, infections, meningitis, and neuropathy) rarely show until late stages, in this case, after the patients develop acquired immunodeficiency syndrome (AIDS). This article aims to review the neurological disorders in the HIV population and the attempts initiated to limit the disease. Methodology: Data were collected from medical journals published on PubMed, Ovid MEDLINE, Science Direct and Embase bibliographical databases with a predefined search strategy. All articles considering neurological disorders associated with HIV were considered. Results: To date, the pathogenesis of HIV-associated neurological complications remains poorly elucidated; thus, imposing a hindrance and limitations on the treatment options. Nevertheless, some studies have reported alterations in dendritic spine as the causative agent for developing brain damage. Conclusion: HIV remains one of the most serious global health challenges, with neurological manifestations imposing a major concern among patients with HIV. Despite the availability and efficacy of antiretroviral therapies, yet, the risk of developing neurological complications remains relatively high among patients with HIV. Thus, the 2030 HIV vision must focus on further preventive measures to protect HIV patients from developing such neurological complications. }, key = {pmid35146953}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2022, title = {Autoimmune thyroid patients with CTLA-4 (+49A/G) GG/AG genotypes have high seropositivity to thyroid peroxidase than thyroglobulin}, author = {Nusrath Fathima and Qursheed Sultana and Syyeda Anees and Kaleem Ullah and Vitaly Ryu and Aleem Ahmed Khan and Mohammed Ishaq}, url = {https://www.sciencedirect.com/science/article/abs/pii/S2214540022000019?via%3Dihub}, doi = {10.1016/j.mgene.2022.101010}, issn = {2773-0441}, year = {2022}, date = {2022-02-01}, urldate = {2022-02-01}, journal = {Meta Gene}, volume = {31}, issue = {suppl C}, pages = {101010}, publisher = {Elsevier BV}, abstract = {Despite increasing burden of autoimmune thyroid disease (AITD) in India, there is paucity of data for the genetic susceptibility in Indian population which represents an important aspect to uncover the genetic factors for the cause or progression of different forms of AITD. It is known that production of auto-antibodies to thyroglobulin (TG) and thyroid peroxidase (TPO) is a characteristic feature of AITD. Production of high titres of auto-antibodies against TG and TPO is one the hallmarks of AITD that often precedes the development of clinical disease. The gene coding for cytotoxic T lymphocyte antigen-4 (CTLA-4) is considered an important candidate gene for susceptibility to AITD and also determines seropositivity. Earlier studies have demonstrated that polymorphic variants in CTLA-4 gene are linked to determine seropositivity. Hence, this study investigates a relationship between CTLA-4 (+49A/G) genotypes and seropositivity to anti-TPO and anti-TG antibodies in AITD patients. A total of 85 Indian participants were included and genotyped for CTLA-4 (+49A/G) single nucleotide polymorphism and further analyzed for seropositivity of TPO and TG auto-antibodies in mean age group of 35.76 ± 12.42 years of both the genders. The TPO seropositivity was reported higher in G allele containing genotypes GG and AG (66.66% and 58%, respectively) compared to AA (44.8%) genotype. Whereas, TG auto-antibodies showed highest seropositivity for genotype AA (55.17%) compared to AG (36%) and GG (16.6%). Higher median titre values were observed for TPO antibodies with GG genotype (1587.461 U/mL). In contrast to this, higher titres of auto-antibodies to TG were observed for individuals with AA genotype (520.746 U/mL). In conclusion, this study demonstrates a relationship between CTLA4 (+49A/G) genotype and seropositivity to thyroid auto antigens TPO and TG in Indian patients with clinical manifestation of Hashimoto's thyroiditis and Graves' disease, two different forms of AITD.}, keywords = {Biochemistry, Central Research Laboratory, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Shaikh_2022, title = {A comparative account using student feedback on diverse modules of e-learning used during COVID-19 lockdown for undergraduate medical teaching}, author = {Fawwad M. Shaikh and Khaja Naseeruddin and Mohammed Sarosh Ahmed and Nabila Afsar and Naseem Begum and Madhipati Sai Krishna and A. Chandrasekhar}, url = {https://jmas.in/fulltext/154-1612924099.pdf?1699089765}, doi = {10.5455/jmas.54405}, issn = {2231-1696}, year = {2022}, date = {2022-01-31}, urldate = {2022-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {12}, issue = {1}, pages = {32-37}, publisher = {Deccan College of Medical Sciences}, abstract = {Need has been the mother of innovation and with the global pandemic of the highly infectious disease COVID 19, there has been a paradigm shift from conventional teaching to digital mode of virtual teaching methods. This task has been achieved by using various platforms available on the digital network, the internet. This work describes the change in medical education, using student feed-back on various modules used in teaching during that period. The feedback survey was conducted online by using the available platforms. The Google forms were used as a survey tool for conducting this survey. The responses were collected from all implied consenting students attending the various teaching sessions across different years of training, belonging to our medical institution. All the participants were adult students attending a medical college. The response rate among the participants was 54%. The respondents were majority 184 (76%) female gender. Nearly 90% opted for Google Meet/classroom as a preferred online module. The choice of selecting this module among the students was found to be statistically significant as compared to other options. The selection was based on the virtue of attributes such as user-friendly application, user satisfaction, beneficial, appealing, less technically challenging, convenient and cost-effective nature. Hence to conclude we may imply to say that this study was unique in assessing the mind of the medical students against this novel e-learning based online mode of education which has taken them by surprise. Though the method is good, there is a lacking that it has; as compared to the conventional means of teaching. This may be used to revise and consolidate the teaching process but not as to replace the classical method rather it should complement it.}, keywords = {Anatomy, Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Tabassum_2022, title = {Evaluation of platelet indices in dengue seropositive cases at a tertiary care hospital in Hyderabad}, author = {Asiya Tabassum and Atiya Begum}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-platelet-indices-in-dengue-seropositive-cases-at-a-tertiary-care-hospital-in-hyderabad-_January_2022_8361510941_2433857.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2022}, date = {2022-01-31}, urldate = {2022-01-31}, journal = {International Journal of Scientific Research}, volume = {11}, issue = {1}, pages = {48-49}, abstract = {Background: Dengue is caused by an arbovirus and is transmitted by mosquito Aedes aegypti. In addition to platelet count, Platelet indices like Mean platelet volume (MPV), Platelet distribution width (PDW) ,Plateletcrit (PCT ) and Platelet large cell ratio (P-LCR) are being investigated as prospective platelet activation indicators. Aims And Objectives: To evaluate the role of platelet indices in dengue seropositive cases. Materials And Methods: This study was a retrospective one conducted on dengue seropositive cases in Department of pathology, Deccan College of medical sciences, Hyderabad. Cases were collected from Dept of medicine and pediatrics over a period of 2 months in Oct-Nov 2021. Blood samples were processed on Sysmex XN 550 automated cell counter and platelet counts were cross checked manually. Results: In this study, Out of 350 samples received, 1OO patients were found to be positive for dengue serology. Male: Female ratio was 1.3:1 with average age being 7.5years .60 % cases had platelet counts below 50,000/cumm. Among platelet indices, 72 % of the patients had mean platelet volume (MPV) less than 8.5; 84 % cases had Plateletcrit less than 0.22 %; 80 % had platelet distribution width (PDW) more than 25  and P-LCR was increased in 56% cases. Conclusion: We observed signicant correlation of low platelet count with MPV, PCT, PDW and P-LCR. MPV is a marker of platelet function and activation, high MPV indicates increased megakaryocytic activity whereas low MPV indicates marrow suppression. PDW is an indicator of platelet anisocytosis and has a negative correlation with low platelet count. P-LCR is inversely related to platelet count and directly related to PDW. It is decreased in patients with thrombocytosis and increased in thrombocytopenia. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2022, title = {A osteology study on morphometric analysis of lower end of femur and its clinical significance }, author = {Zafar Sultana Abdul Saleem and Mohammed Khaleel Ahmed}, url = {https://www.jcdronline.org/admin/Uploads/Files/62d6e0a5d03cb9.24712517.pdf}, issn = {0975-3583}, year = {2022}, date = {2022-01-31}, urldate = {2022-01-31}, journal = {Journal of Cardiovascular Disease Research}, volume = {13}, issue = {1}, pages = {1835-1842}, abstract = {Introduction: The knee joint is a complex variety of synovial joint in which lower end of femur articulates with the upper end of tibia and patella forming femorotibial and femoropatellar articulations respectively. Anteriorly articular surfaces of both femoral condyles are continuous with each other but posteriorly they are separated by the intercondylar notch. Materials and methods: An observational descriptive study with cross-sectional data collection was conducted. The study was carried out on 90 (48 right and 42 left) randomly selected, intact, dry, completely ossified femurs of unknown age, stature and sex from the Department of Anatomy of Deccan college of medical sciences, Hyderabad, Results: We studied 90 bones,48 femur were of right side and 42 were of left side. Mean bicondylar width [BCW] was 75.95±5.87mm on right side and 76.17±5.36mm on left side. Maximum anteroposterior distance of medial condyle was 57.79±5.81mm on right side and 59.49±4.06mm on left side. Conclusion: The values obtained in present study and comparing them with other studies from Indian and foreign authors clearly shows variances are there not only in different ethnic groups but indifferent populations in India.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Sarepally_2022, title = {A comparative evaluation of 2.0mm two-dimensional miniplates versus 2.0mm three-dimensional miniplates in mandibular fractures}, author = {Godvine Sarepally and Swetcha Seethamsetty and Tanveer Karpe and Fazil A. Nasyam and Umayra Fatima and Raia Fatema}, url = {https://assets.cureus.com/uploads/original_article/pdf/82777/20220216-2488-o27plt.pdf}, doi = {10.7759/cureus.21325}, issn = {2168-8184}, year = {2022}, date = {2022-01-17}, urldate = {2022-01-17}, journal = {Cureus}, volume = {14}, issue = {1}, pages = {e21325}, publisher = {Cureus, Inc.}, abstract = {Background: In the past few decades, there has been an increasing interest in obtaining a more instantaneous return to normal function using diverse methods of direct fixation. Aims and Objectives: To compare the conventional 2-mm 2D (two-dimensional) miniplates and 2-mm 3D (three-dimensional) miniplates in terms of treatment outcome, stability, duration of surgery, and complications of treatment of symphysis and parasymphysis mandibular fractures. Materials and Methods: 16 patients with clinical and radiological evidence of fractures of the mandible in symphysis and parasymphysis areas treated by open reduction and internal fixation with 2D miniplates and 3D miniplates. The patients were followed up for three months and assessed clinically and radiographically by taking orthopantomograms. The assessment was made on the immediate postoperative day, third day, fifth day, the seventh day, two weeks, three weeks, four weeks, two months, and three months. Results: Mean intraoperative time taken for 2D miniplate was 54.8 min and for 3D miniplate was 40.6 min. Mild paraesthesia at the soft tissue region supplied by mental nerve was noticed in two patients (25%) of group I, whereas there was no such paraesthesia observed in group II patients. Wound dehiscence and infection were noticed in one patient in group I. Conclusion: 3D plates seem to be better than conventional 2-mm miniplates for symphysis and parasymphysis fractures. }, key = {pmid35186584}, keywords = {Dentistry}, pubstate = {published}, tppubtype = {article} } @inbook{Haneef_2022, title = {Alopecia areata}, author = {Nayeem Sadath Haneef}, editor = {S. Sacchidanand and A. S. Savitha and K. Shilpa and B. M. Shashi Kumar}, isbn = {9789381496701}, year = {2022}, date = {2022-01-01}, booktitle = {IADVL textbook of dermatology}, publisher = {Bhalani Publishing House}, address = {Mumbai}, edition = {5th}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {inbook} } @article{Manorenj_2022d, title = {Diagnostic performances of susceptibility weighted imaging brain for the detection of cerebral venous thrombosis in patients presenting with headache}, author = {Sandhya Manorenj and Sravan Kumar Marupaka and Kiran Kumar Ramineni}, url = {https://www.ijcmsr.com/uploads/1/0/2/7/102704056/ijcmsr_585_v1.pdf}, issn = {2565-4802}, year = {2022}, date = {2022-01-01}, journal = {International Journal of Contemporary Medicine Surgery and Radiology}, volume = {7}, issue = {1}, pages = {A29-A33}, abstract = {Introduction: Magnetic resonance venography (MRV) brain is the gold standard for diagnosing cerebral venous thrombosis (CVT). Susceptibility-weighted imaging (SWI) is a high-spatial resolution, (MR) technique that is exquisitely sensitive to venous blood, hemorrhage and iron storage. Study aimed to know the diagnostic performance of SWI in detecting CVT compared to MRV and to facilitate early diagnosis of CVT where MRV not feasible. Material and Methods: A prospectively study, included patients presenting with clinical symptoms of CVT who underwent MRI (1.5T) brain with MRV. We determined the sensitivity, specificity, predictive value, accuracy, degree of agreement between SWI and MRV in detecting CVT. Results: Out of 100 cases, 64 were females. Majority of patients presented with headache (100%) and CVT was diagnosed in 55 cases. Majority of patient had transverse sinus (TS) thrombosis (54%). The overall diagnostic accuracy of SWI sequence was 76.31% and that of MRV was 95.18%. Sensitivity of SWI versus MRV was 63.22% Vs 91.23%; Specificity 92.31% Vs 100%; Positive predictive value 90.95% vs 100%; Negative predictive value 67.25% vs 90.32% respectively. 95% confidence interval was observed for the specificity and positive predictive value of the SWI test. There exists good degree of agreement between both imaging modalities with 98% accuracy to detect cortical vein thrombosis by SWI. Conclusion: SWI sequence added on the conventional MRI can be used as the first line imaging modality for evaluation of patient with CVT where MRV brain is not feasible. SWI has higher diagnostic performance in detecting isolated cortical vein thrombosis.}, keywords = {Neurology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Jafari_2022, title = {Paroxysmal sympathetic hyperactivity during traumatic brain injury}, author = {Amirhossein Azari Jafari and Muffaqam Shah and Seyyed Mohammad Sadeq Mirmoeeni and Maryam Sadat Hassani and Shahrzad Nazari and Tristan Fielder and Daniel Agustin Godoy and Ali Seifi}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0303846721006107?via%3Dihub}, doi = {10.1016/j.clineuro.2021.107081}, issn = {0303-8467}, year = {2022}, date = {2022-01-01}, urldate = {2022-01-01}, journal = {Clinical Neurology and Neurosurgery}, volume = {212}, pages = {107081}, publisher = {Elsevier BV}, abstract = {Traumatic brain injury (TBI) is one of the leading causes of disability, morbidity, and mortality worldwide. Some of the more common etiologies of TBI include closed head injury, penetrating head injury, or an explosive blast head injury. Neuronal damage in TBI is related to both primary injury (caused by mechanical forces), and secondary injury (caused by the subsequent tissue and cellular damages). Recently, it has been well established that Paroxysmal Sympathetic Hyperactivity (PSH), also known as “Sympathetic Storm”, is one of the main causes of secondary neuronal injury in TBI patients. The clinical manifestations of PSH include recurrent episodes of sympathetic hyperactivity characterized by tachycardia, systolic hypertension, hyperthermia, tachypnea with hyperpnea, and frank diaphoresis. Given the diverse manifestations of PSH and its notable impact on the outcome of TBI patients, we have comprehensively reviewed the current evidence and discussed the pathophysiology, clinical manifestations, time of onset and duration of PSH during TBI. This article reviews the different types of head injuries that most commonly lead to PSH, possible approaches to manage and minimize PSH complications in TBI and the current prognosis and outcomes of PSH in TBI patients.}, key = {pmid34861468}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ashok_2022b, title = {Variations in the origin of middle hepatic artery in living liver donors using CT angiography in South Indian population: A retrospective study}, author = {Panjala Ashok and Gunapriya Raghunath and Vanacharala Anantha Kumari and B. H. Shiny Vinila}, url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2022&volume=16&issue=1&page=AC01&issn=0973-709x&id=15858}, doi = {10.7860/jcdr/2022/53227.15858}, issn = {0973-709X}, year = {2022}, date = {2022-01-01}, urldate = {2022-01-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {16}, issue = {1}, pages = {AC01-AC03}, publisher = {JCDR Research and Publications}, abstract = {Introduction:The middle hepatic artery is an artery which supplies blood to the fourth segment of the liver. Most commonly, it originates from the right hepatic artery. Injury to the middle hepatic artery during liver transplant surgeries may lead to ischaemia and also may lead to life threatening conditions like hepatic artery thrombosis in donor as well as recipient. The variations in the origin of the middle hepatic artery in the living donors were focused in the present study as it has surgical importance in the liver transplantations. Aim: To find out the incidence of the variations in the origin of the middle hepatic artery in living liver donors using Computed Tomography (CT) angiography. Materials and Methods: This was a retrospective observational study conducted from August 2018 to October 2021 in the Department of Anatomy, Deccan College of Medical Sciences, Hyderabad, Telangana, India. The images of CT angiographies of 100 living liver donors were collected from the Department of Radiology, Global Hospital, Hyderabad, Telangana, India. All the CT angiographs of the living liver donors were observed for any variations in the origin of the middle hepatic artery and recorded and the percentage of each variation was calculated. Results: Out of 100 CT angiographs studied, the incidence of the origin of middle hepatic artery was reported as 55% from right hepatic artery, 34% from the left hepatic artery, 5% from replaced left hepatic artery, 2% from the hepatic artery proper, 1% from the common hepatic artery, 1% from left gastric artery. Double middle hepatic arteries were observed in 1% of cases. Accessory middle hepatic artery was observed in 1% cases. Conclusion: To increase the success rate of liver transplantations, the clear knowledge on the possible variations of the middle hepatic artery is needed. The variations of the middle hepatic artery reported in this study are rare and will be useful for the liver transplant surgeons.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Basha_2022, title = {Streeter's syndrome of lower limb associated with CTEV}, author = {Md. Jaan Basha and Mohmad Irfan Nagnur and Mohammed Siddique Mohiuddin and Mohammed Jalal Mohiuddin and Sajid Salman and Chavva Shamsunder}, url = {https://jocr.co.in/wp/show-pdf/?file=43533}, doi = {10.13107/jocr.2022.v12.i12.3460}, issn = {2250-0685}, year = {2022}, date = {2022-01-01}, urldate = {2022-01-01}, journal = {Journal of Orthopaedic Case Reports}, volume = {12}, issue = {12}, pages = {50-53}, publisher = {Indian Orthopaedic Research Group}, abstract = {Introduction: The term Streeter’s syndrome is a term used to describe rare congenital malformations that includes a variety of clinical presentations usually consisting of a constriction band around a part of the body which can be as superficial as involving just the skin which can be only cosmetic and asymptomatic or can be as deep as causing restricted circulation distally which may be in incompatible with life. Such conditions are remarkably rare accounting for an incidence range from 1:1.2 k to 1: 15 k live births and 178:10 k spontaneous abortions [1]. Males and females are uniformly affected. Almost all cases are sporadic; extremely rare evidence of familial transmission. The entity has been described in the literature in 34 different terms, (such as amniotic rupture sequence, ADAM complex, constriction band syndrome, Streeter’s dysplasia, etc.) due to its extremely variable clinical features and lack of understanding of the etiology. This results in a lack of understanding and creates unnecessary stress for the surgeon/physician as well as the parents. Case Report: We discuss case reports of two such cases with their simple nature of treatment with their outcomes. Conclusion: There is a significant deficit in the education of cases with low incidence, such is the case with pediatric patients presenting with amniotic bands, which usually present and are associated with Congenital Talipes Equino Varus deformity. In such cases, improper or incorrect treatment and/or neglect of the constriction may lead to the vascular deficit and eventually auto-amputation of the segment distal to the amniotic band.}, key = {pmid37056605}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Shaik_2022b, title = {"Neuroleptic malignant syndrome (NMS) sans rigidity" .....Does it exist??}, author = {Reshma Sultana Shaik and Sandhya Manorenj and Rindha V. Rao}, url = {https://journals.lww.com/annalsofian/fulltext/2022/2506/_neuroleptic_malignant_syndrome__nms__sans.62.aspx}, doi = {10.4103/aian.aian_593_22}, issn = {0972-2327}, year = {2022}, date = {2022-01-01}, urldate = {2022-01-01}, journal = {Annals of Indian Academy of Neurology}, volume = {25}, issue = {6}, pages = {1235-1236}, publisher = {Medknow}, key = {pmid36911465}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2021b, title = {Comparison of medial longitudinal arches of the foot by radiographic method in users and nonusers of high-heeled footwear among young women}, author = {Saimah Naseer and Ravindra Prakash Babu and Panjala Ashok and Mehnaaz Sameera Arifuddin and Hunaina Manfusa and Ephraim Vikram Rao}, url = {https://journals.lww.com/joai/Fulltext/2021/70040/Comparison_of_Medial_Longitudinal_Arches_of_the.7.aspx}, doi = {10.4103/jasi.jasi_202_20}, issn = {2352-3050}, year = {2021}, date = {2021-12-31}, urldate = {2021-12-31}, journal = {Journal of the Anatomical Society of India}, volume = {70}, issue = {4}, pages = {226-232}, publisher = {Wolters Kluwer - Medknow}, abstract = {Introduction: The arches of the foot help in transmission of the body weight and permit adjustments on uneven surfaces. Prolonged use of high heels causes elevation or collapse of these arches by stress and strain over the weight-bearing bones, and also causes damage to the underlying soft tissues and ligaments. The aim of this study was to document the presence of any changes in medial longitudinal arches in young women using high heels through radiographic method taking into account body mass index, height of heels, and the type of shoes worn and to document lower back pain and foot pain. Material and Methods: An observational study between 40 high-heel wearers and 40 flat wearers was done. Lateral radiographs of both feet were taken in weight-bearing position with medial border of the foot touching the cassette. Lateral talocalcaneal angle, lateral talar-first metatarsal angle, angle of longitudinal arch, and calcaneal pitch were measured by a protractor and goniometer. A questionnaire documented complaints of back pain and foot pain. Results: Independent sample t-test showed a statistically significant difference in left lateral talar-first metatarsal angle between two groups. Pearson's correlation showed a negative correlation between left lateral talocalcaneal angle and low back pain, and a positive correlation between right lateral talar-first metatarsal angle and low back pain. Discussion and Conclusion: Frequent and prolonged use of high-heeled footwear can result in damage to the foot architecture leading to foot and back pain. Thus, keeping the high heels reserved for occasional use is the best choice.}, keywords = {Anatomy, Physiology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Lakkireddy_2021, title = {Biofabrication of allogenic bone grafts using cellularized amniotic scaffolds for application in efficient bone healing}, author = {Chandrakala Lakkireddy and Sandeep Kumar Vishwakarma and Avinash Bardia and Nagarapu Raju and Shaik Iqbal and Syeda Maliha Fathima and Sandhya Annamaneni and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0040816621001476?via%3Dihub}, doi = {10.1016/j.tice.2021.101631}, issn = {0040-8166}, year = {2021}, date = {2021-12-31}, urldate = {2021-12-31}, journal = {Tissue and Cell}, volume = {73}, pages = {101631}, abstract = {Introduction: The reconstruction/regeneration of human bone injuries/defects represents a crucial challenge due to the lack of suitable bio/immune compatible and implantable biological grafts. The available strategies represent implications of several types of grafting materials in the form of metals, synthetic, and various kinds of biological scaffolds; however, the lack of appropriate biological components required for activating and enhancing repair mechanisms at the lesion-site limits their wider applicability. Methods: In this study, a unique approach for generating human osteogenic implantable grafts was developed using biofabrication technology. Using a gradient change of detergents and continuous agitation, developed a unique technique to generate completely cell-free amnion and chorion scaffolds. The absence of cellular components and integrity of biological and mechanical cues within decellularized human amnion (D-HAM) and chorion (D-HCM) were evaluated and compared with fresh membranes. Allogenic bone grafts were prepared through induction of human mesenchymal stem cells (hMSCs) into osteogenic cells on D-HAM and D-HCM and evaluated for their comparative behavior at the cellular, histological and molecular levels. Results: The common decellularization process resulted in an efficient way to generate D-HAM and D-HCM while retaining their intact gross-anatomical architecture, surface morphology, extracellular matrix components, and mechanical properties. Both these scaffolds supported better growth of human umbilical cord blood derived MSCs as well as osteogenic differentiation. Comparative investigation revealed better growth rate and differentiation on D-HCM compared to D-HAM and control conditions. Conclusion: D-HCM could be used as a better choice for producing suitable allogenic bone grafts for efficient bone healing applications. }, keywords = {Central Research Laboratory, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Golla_2021b, title = {Risk factors and coronary angiographic profile in young STEMI patients: results from a tertiary care centre in south-central India}, author = {Abhishek Golla and Parvaiz Kadloor and Rajashekar Reddy Gurrala and Kazi Jawwad Hussain and Kolli Sivadayal and K. Laxman Rao and Mohammed Hidayathulla and Shabbik Ali Shaikani }, url = {https://www.msjonline.org/index.php/ijrms/article/view/10442/6922}, doi = {10.18203/2320-6012.ijrms20215040}, issn = {2320-6012}, year = {2021}, date = {2021-12-28}, urldate = {2021-12-01}, journal = {International Journal of Research in Medical Sciences}, volume = {10}, issue = {1}, pages = {111-115}, publisher = {Medip Academy}, abstract = {Background: Compared to older counterparts, a significant distinction has been found related to risk factors, clinical presentation, and prognosis of ST-segment elevation myocardial infarction (STEMI) in younger patients. To date, a lack of studies has been looked, specifically at-risk factors and angiographic profile of STEMI among younger patients; with this in mind, we conducted the present study. Methods: This hospital-based, cross-sectional, open-label study was carried out at Deccan College of Medical Sciences between April 2018 and December 2019. Patients under 40 years with the presentation of STEMI were included. All patients were subjected to electrocardiography, 2D echocardiography, and coronary angiogram. Baseline demographics, risk factors, and procedural characteristics were recorded. Results: Of 51 young STEMI patients, 41 (80.4%) were male and 10 (19.6%) were female. The most common risk factors associated with the development of STEMI in young patients were smoking (58.8%), followed by diabetes (45.1%), and dyslipidaemia (45.1%). Anterior wall MI was the most frequent presentation (84.3%). The left anterior descending artery was the most frequently (62.8%) involved vessel, followed by left circumflex artery (9.8%), and right coronary artery (5.9%). Conclusions: Insights gained from the study can aid in identifying clinical characteristics of STEMI in young patients, which may be beneficial to achieve appropriate and timely management. Further, the young population should be educated as to control modifiable risk factors and smoking cessation to prevent coronary artery disease since they belong to the highly productive group in the community.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Kadloor_2021, title = {Reduced left ventricular ejection fraction in patients with acute coronary syndrome as a risk factor for mortality}, author = {Parvaiz Kadloor and Mohammed Hidayathulla and Abhishek Golla}, url = {https://www.msjonline.org/index.php/ijrms/article/view/10423/6917}, doi = {10.18203/2320-6012.ijrms20215035}, issn = {2320-6012}, year = {2021}, date = {2021-12-28}, urldate = {2021-12-01}, journal = {International Journal of Research in Medical Sciences}, volume = {10}, issue = {1}, pages = {80}, publisher = {Medip Academy}, abstract = {Background: The study aimed to evaluate left ventricular ejection fraction (LVEF) as the risk factor for mortality in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). Methods: This was an observational, single centre study. The patients who were admitted at tertiary care centre in India during the period February 2014 to June 2015 who were diagnosed with ACS were included in the study. The patients were evaluated by dividing into two groups based on LVEF. The patients were followed up to 1 year. Results: Total 100 patients were included in the study. Chest pain was the most prevalent complaint (60%). Seventy patients presented with STEMI (ST-segment elevation myocardial infarction) and 30 with NSTEMI (non-ST-segment elevation myocardial infarction). Seventy five patients had ejection fraction ≥40% and 25 patients had reduced ejection fraction. Reduced LVEF did not show any statistical difference in patients with presentation as STEMI and NSTEMI or need for revascularisation. At year follow up, total 9 patients died. However, reduced LVEF led to statistically higher deaths (p<0.05%). Conclusions: In our study it was observed that patients with ACS complicated by heart failure with reduced ejection fraction have a markedly increased short- and long-term mortality rates compared to ACS patients without heart failure.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Shakeeb_2021, title = {Giant ovarian cyst in 18 year old female– a case report}, author = {Momin Shakeeb and Heena Khatoon and Alina Khan and Sumaiya Sehrish and Syed Murtuza Hashmi and Mohammed Nizamuddin and Wafa Yasmeen}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/giant-ovarian-cyst-in-18-year-old-female--a-case-report_December_2021_3856870186_6100423.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2021}, date = {2021-12-01}, urldate = {2021-12-01}, journal = {International Journal of Scientific Research}, volume = {10}, issue = {12}, pages = {10-12}, abstract = {Ovarian cysts are common, and are usually less than 4cm. A giant cyst in one which is more than 10cm. Giant cystadenocarcinomas of the ovary are less frequently described. Most of the ovarian carcinomas are of serous type and only 3-4% are of mucinous type. Ovarian mucinous tumors consist of benign, borderline, and carcinomatous tumors. Giant cysts require resection because of compressive symptoms and/or risk of malignancy and their management invariably requires laparotomy to prevent perforation and spillage of the cyst uid into peritoneal cavity. Here, we present a case of an 18 year old female with rapidly progressing abdominal distension and vague abdominal pain. Along with clinical evaluation and lab investigations she was subjected to imaging which included Ultrasonography and MR Imaging. She underwent exploratory laparotomy for excision of the cystic mass. On histopathological examination, mass was found to be mucinous cystadenocarcinoma with low malignant potential. The main aim of this report is to draw attention to huge ovarian epithelial cysts with unsuspected presentation contributing to any underdiagnosis, misdiagnosis, and mismanagement that might occur.}, keywords = {General Surgery, Otorhinolaryngology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Abdullah_2021, title = {Prevalence of airway reversibility in connective tissue disease-interstitial lung disease (CTD-ILD)}, author = {Fahad Abdullah Bin Breik and Ashfaq Hasan and Moid Mir Siddiq Ali and Rahmath Fida and Sufia Iram Irshad}, url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/13347/10539}, doi = {10.53730/ijhs.v6ns8.13347}, issn = {2550-696X}, year = {2021}, date = {2021-12-01}, urldate = {2021-12-01}, journal = {International Journal of Health Sciences}, volume = {6}, issue = {S8}, pages = {4989-4994}, publisher = {Universidad Tecnica de Manabi}, abstract = {Background: Spirometry is the most reproducible and objective measurement of airflow limitation. Improvement in FEV1 and/or FVC by 12% or 200ml after using bronchodilator is definitive of reversible airway disease.[1] Several conditions like sarcoidosis predominantly involve the interstitium have nevertheless been associated with reversible airways obstruction. Connective tissue diseases (CTDs) form another important subgroup of interstitial lung disease(ILD). CTDs usually produce a restrictive pattern of lung involvement on spirometry, but might have unrecognized additional reversible airway obstruction. Seeking out and treating the latter components of disease may be crucial in optimizing lung function and alleviating the breathlessness that is common to the problem. Aim: The aim of this study is therefore to determine the post bronchodilator response in patients with connective tissue disease related interstitial lung disease (CTD-ILD) and thus potentially help improve quality of life by addressing the latter component by inhaled bronchodilator-steroid therapy. Methods: Consecutive patients with a confirmed diagnosis of CTD-ILD were identified in the out-patient clinics of our institute. CTD was diagnosed by a combination of clinical and serological parameters. ILD was confirmed by high resolution computed tomography (HRCT) images.}, keywords = {Deccan School of Pharmacy, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Golla_2021, title = {Comparative study of echocardiography and electrocardiographycriteria for detecting left ventricular hypertrophy in hypertensive patients}, author = {Abhishek Golla and Ramkumar V. S. and Ashok Kumar P. and Ravindranath S. and Indira Ramaiah and Veena N. and Vikram Adithya and Rajashekar Reddy Gurrala and Kazi Jawwad Hussain}, url = {https://www.msjonline.org/index.php/ijrms/article/view/10161/6830}, doi = {10.18203/2320-6012.ijrms20214418}, issn = {2320-6012}, year = {2021}, date = {2021-11-30}, urldate = {2021-11-30}, journal = {International Journal of Research in Medical Sciences}, volume = {9}, issue = {11}, pages = {3364-3369}, abstract = {Background:The study aimed to compare seven different electrocardiogram (LVH) criteria for diagnosing left ventricular hypertrophy (LVH) with echocardiogram as diagnostic standard in hypertensive patients. Methods:This was a hospital-based, cross-sectional study conducted in out-patient department and at medical wards of a tertiary care hospital at Bangalore. The study was carried out for a total duration of 12 months. All hypertensive patients underwent examination for prevalence of LVH using echocardiogram and ECG. Seven different ECG criteria were applied to diagnose the presence of LVH. Then the specificity, sensitivity, kappa measurement value, positive predictive value and negative predictive value for all criteria was calculated subsequently. Results:Out of the 100 patients studied, 34 had LVH as diagnosed by echocardiography. Sokolow-Lyon criteria had a sensitivity of 35% and specificity of 94%. Cornell voltage had a sensitivity of 26% and specificity of 95%. Modified Cornell voltage had a sensitivity of32% and specificity of 94%. Framingham adjusted Cornell voltage, Minnesota code and Cornell product had a sensitivity of 23.5% and specificity of 98.4%. Framingham score had a sensitivity of 38% and specificity of 95.4%. Conclusions:It can be concluded that among all the different criteria used in the study, Framingham score showed better sensitivity compared to others. In the evaluation of hypertensive patients for LVH, the role of ECG with all the commonly used criteria is of limited value and echocardiography is the method of choice.}, keywords = {Cardiology}, pubstate = {published}, tppubtype = {article} } @article{Anjum_2021b, title = {A cross-sectional study of precautions followed by patients attending primary health centre during the lockdown period of Covid-19}, author = {Vaseem Anjum and Mehaboobi Shaik}, url = {https://ijhcr.com/index.php/ijhcr/article/view/3168/3031}, issn = {2590-3241}, year = {2021}, date = {2021-11-21}, urldate = {2021-11-21}, journal = {International Journal of Health and Clinical Research}, volume = {4}, issue = {20}, pages = {8-12}, abstract = {During the lockdown period of the COVID 19 pandemic in 2021 the patients approaching the primary health centre were studied for a period of 3 months, from March to May in Hyderabad city. The precautions taken by these patients were also recorded using a semi-structured questionnaire. Among the 223 subjects mean age was 27.88 years, 61.9% were females, 83.4% were educated and 47.1% belonged to the SES III. Majority (50.2%) of patients were between 15 to 40 years. Below the age of 15 years constituted 28.3% and those above 40 years were 21.5%. In the study group only 12.6% suspects were asymptomatic, 31.8% had only fever, 49.3% had fever and URTI, while 6.3% had SOB along with fever and URTI. 1.8% had interstate travel history in past 15 days. 5.8% had history of contact with a COVID-19 patient or suspect. 65% patients took precautions. Under the preventive measures hand washing was 59.6% among which 69.2% used soap–water and 30.8% used alcohol rub to clean hands. 51.2% used mask while 48.2% did not use any protection. In this study the clinical symptoms were significant with age, sex, SES and preventive measures taken (p<0.05) but there was no significant association with presence of comorbidity.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2021b, title = {Congenital pyloric atresia: experience with a series of 11 cases and collective review}, author = {G. Raghavendra Prasad and J. V. Subba Rao and Firdous Fatima and Fariha Anjum}, url = {https://www.jiaps.com/temp/JIndianAssocPediatrSurg266416-2971273_081512.pdf}, doi = {10.4103/jiaps.JIAPS_295_20}, issn = {0971-9261}, year = {2021}, date = {2021-11-12}, urldate = {2021-11-12}, journal = {Journal of Indian Association of Pediatric Surgeons }, volume = {26}, issue = {6}, pages = {416-420}, abstract = {Introduction: Pyloric atresia is a rare cause of congenital gastric outlet obstruction. It is often associated with epidermolysis bullosa (EB). Rarity and experience with 11 cases are the reason for this publication. Aims and Objectives: The aim and objective of this study is to present our experience of 11 cases of congenital pyloric atresia and correlate with available literature. Materials and Methods: This was retrospective cohort of 11 cases correlative comparative study. Data of all the 11 cases from 1982 to 2019 were collected, reviewed, and analyzed. The parameters studied included age, gender, antenatal diagnosis, postnatal diagnosis, preoperative management, intraoperative findings, postoperative course outcome, associated anomalies, and any genetic studies if done. All these parameters were compared with published data. Results: There were 11 cases in the present series with six boys and five girls. Most of them presented at varying periods from birth to day 1 of life. Eight cases of type 1 pyloric atresia, two cases of type 2 pyloric atresia, and one case of type 3 pyloric atresia constituted the cohort. Five out of 11 cases were associated with EB. Two out of six cases with isolated pyloric atresia and four out of five cases with EB died. Discussion: Congenital pyloric atresia may be isolated or associated with EB. Three varieties of pyloric atresia were described. Association with EB increases the mortality. Conclusions: Review and analysis of 11 cases of pyloric atresia compared with published literature is being reported. }, keywords = {Anesthesiology, General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Khan_2021d, title = {Kikuchi-Fujimoto disease in a young female: a case report and literature review}, author = {Aadil M. Khan and Moinuddin Ahmad and Owaise Muhammad and Shafaq Taj and Saher T. Shiza}, url = {https://www.cureus.com/articles/71886-kikuchi-fujimoto-disease-in-a-young-female-a-case-report-and-literature-review#!/}, doi = {10.7759/cureus.19321}, issn = {2168-8184}, year = {2021}, date = {2021-11-06}, urldate = {2021-11-01}, journal = {Cureus}, volume = {13}, issue = {11}, pages = {e19321}, publisher = {Cureus, Inc.}, abstract = {Kikuchi-Fujimoto disease (KFD) is histiocytic necrotizing lymphadenitis, a rare immune-mediated disorder presenting with lymphadenopathy, leukopenia, and occasionally fever. Herein we report a case of KFD who presented with anorexia, fever, and cervical lymphadenopathy. Lymph node biopsy and immunohistochemistry confirmed the diagnosis of KFD. She was treated with prednisolone and paracetamol, and her condition improved gradually on subsequent follow-up. A patient presenting with fever and lymphadenopathy leads to prompt investigations for common diseases such as tuberculosis and lymphoma. However, rare diseases like KFD must be kept in mind, and a lymph node biopsy followed by histopathologic examination and immunohistochemistry should be done to confirm the diagnosis.}, key = {pmid34900492}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Nasirabadi_2021, title = {Mental health issues in Covid-19}, author = {Minhajzafar Nasirabadi and Mazher Ali and Ayesha Vaseem}, url = {https://www.tjima.org/journal/index.php/tjima/article/view/36/63}, doi = {10.52314/tjima.2021.v1i2.36}, year = {2021}, date = {2021-10-30}, urldate = {2021-10-30}, journal = {Telangana Journal of IMA}, volume = {1}, issue = {2}, pages = {30-35}, abstract = {The COVID-19 pandemic has had a dramatic impact on human life worldwide and presented with an unprecedented challenge to public health. As evidenced by many studies the devastating economic and social disruption caused by the pandemic has led to an increase in incidence of depression, anxiety, PTSD & suicide. Stigma was also a factor for those affected by the disease, their care givers and frontline health care providers}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Nasirabadi_2021b, title = {Empowering practitioners in helping patients with common mental health issues}, author = {Minhajzafar Nasirabadi and Mazher Ali and Ayesha Vaseem}, url = {https://journals.lww.com/tjima/abstract/2021/01020/empowering_practitioners_in_helping_patients_with.10.aspx}, doi = {10.52314/tjima.2021.v1i2.35}, year = {2021}, date = {2021-10-30}, urldate = {2021-10-30}, journal = {Telangana Journal of IMA}, volume = {1}, issue = {2}, pages = {27-29}, abstract = {Depression and anxiety disorders are the most common mental illnesses and account for much of the disease burden. They affect an individual at some point in the life span having direct impact on overall health affecting a person’s daily life. Although these are common disorders, they can also be quite serious and in most cases are highly or completely treatable. Despite the magnitude of the problem, scarcity of psychiatrists coupled with lack of awareness in the general population, result in most patients not receiving adequate treatment. A lot of patients approach primary health care physicians seeking treatment for some somatic symptoms of depression or anxiety. Given sufficient sensitization and training, they can facilitate early identification and ensure proper treatment. Furthermore, the decisions regarding response and duration of treatment and need for adjunctive therapy or alternative medication can be made in conjunction with a team of mental health care providers. }, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2021b, title = {Chronic psychiatric illness masquerading as bipolar disorder in a family secondary to familial systemic lupus erythematosus with limbic encephalitis}, author = {Sandhya Manorenj and Reshma Sultana Shaik}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522607/?report=reader#__ffn_sectitle}, doi = {10.4103/indianjpsychiatry.indianjpsychiatry_178_21}, issn = {0019-5545}, year = {2021}, date = {2021-10-12}, urldate = {2021-10-12}, journal = {Indian Journal of Psychiatry}, volume = {63}, issue = {5}, pages = {517-519}, abstract = {NA}, key = {pmid34789947}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Suheb_2021b, title = {Concealed malignancy as a rare cause of refractory lactic acidosis: a fatal case}, author = {Mahammed Z. Khan Suheb and Wasey Ali Yadullahi Mir and Farheen Naaz and Dhan B. Shrestha and Anuj K. Paudel}, url = {https://www.cureus.com/articles/66792-concealed-malignancy-as-a-rare-cause-of-refractory-lactic-acidosis-a-fatal-case#!/}, doi = {10.7759/cureus.18602}, issn = {2168-8184}, year = {2021}, date = {2021-10-08}, urldate = {2021-10-01}, journal = {Cureus}, volume = {13}, issue = {10}, pages = {e18602}, publisher = {Cureus, Inc.}, abstract = {Lactic acidosis is a state in which there is a buildup of lactate in the body to form an excessively low pH in the blood. Elevated lactate levels are often thought to be indicative of relative tissue hypoxia or type A lactic acidosis. Shock, severe anemia, and thromboembolic events can all cause elevated lactate due to tissue hypoperfusion. Malignancy can also lead to an elevation in lactate, a phenomenon described as type B lactic acidosis. Here, we report a case of a 66-year-old male with elevated lactate level, which was refractory to medical treatment. Despite adequate management, including continuous renal replacement therapy, the lactate continued to rise, and consequently, the patient died due to cardiac arrest. Type B lactic acidosis must be considered in patients with elevated lactate levels without hypotension as it has a high mortality rate.}, key = {pmid34786220}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Anees_2021, title = {OSPE in Biochemistry - A step towards implementation of competency based undergraduate curriculum}, author = {Syyeda Anees and Sheetal Harakuni and Ruksana Kausar}, url = {https://www.ijcbr.in/article-details/14938}, doi = {10.18231/j.ijcbr.2021.049}, issn = {2394-6369}, year = {2021}, date = {2021-10-01}, urldate = {2021-10-01}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {8}, issue = {3}, pages = {234-236}, publisher = {IP Innovative Publication Pvt Ltd}, abstract = {Background: Competency based undergraduate curriculum stresses on objectivity, uniformity, validity and reliability of the assessment tools since assessment drives learning. Conventional Practical Examination (CPE) in Biochemistry is subjective and associated with examiner variability and raises concerns over its validity and reliability. Objective Structured Practical Examination(OSPE) addresses this problem as it includes objective testing through direct observation, assessment of knowledge, comprehension and skills.In this study the performance of 1 MBBS students in CPE & OSPE was compared & perception of students and faculty towards OSPE as Formative Assessment was evaluated. Materials and Methods: Study included total of 150 Phase 1 MBBS students of 2019-20 batch & faculty of Biochemistry were included. CPE and OSPE was conducted on topic “Estimation of Blood Glucose” and marks were awarded.OSPE was conducted with 2 procedure & 4 response stations. Statistical Analysis: Percentage graphs & Student’s’ test using MS Excel were used. Results: There was statistically significant difference between the mean scores of CPE and OSPE (P < 0> Interpretation & Conclusion: Our study concludes that the scores of OSPE were better than that of CPE. OSPE eliminated examiner bias by integration of cognitive, psychomotor and affective domains. Therefore OSPE can be introduced as Formative Assessment & Summative Assessment.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Lakkireddy_2021, title = {Fabrication of decellularized amnion and chorion scaffolds to develop bioengineered cell-laden constructs}, author = {Chandrakala Lakkireddy and Sandeep Kumar Vishwakarma and Nagarapu Raju and Shaik Iqbal Ahmed and Avinash Bardia and Mazharuddin Ali Khan and Sandhya Annamaneni and Aleem Ahmed Khan}, url = {https://link.springer.com/article/10.1007/s12195-021-00707-7}, doi = {10.1007/s12195-021-00707-7}, issn = {1865-5025}, year = {2021}, date = {2021-09-24}, urldate = {2021-09-01}, journal = {Cellular and Molecular Bioengineering}, volume = {15}, issue = {1}, pages = {137-150}, publisher = {Springer Science and Business Media LLC}, abstract = {Introduction: Human mesenchymal stem cells (hMSCs) holds great promise for managing several clinical conditions. However, the low engraftment efficiency and obscurity to harvest these cells without compromising the cellular viability, structural and functional properties from the culture niche still remain major obstacles for preparing intact regenerative constructs. Although few studies have demonstrate different methods for generating cell-liberated amniotic scaffolds, a common method for producing completely cell-liberated amnion (D-HAM) and chorion (D-HCM) scaffolds and their cytocompatibility with hMSCs yet to be demonstrated. Methods: A common process was developed for preparing D-HAM and D-HCM scaffolds for assessing hMSCs engraftment efficiency, proliferation and molecular shifts to generate cell-laden biological discs. The structural and functional integrity of D-HAM and D-HCM was evaluated using different parameters. The compatibility and proliferation efficiency of hMSCs with D-HAM and D-HCM was evaluated. Results: Histological analysis revealed completely nucleic acid-free D-HAM and D-HCM scaffolds with intact extracellular matrix, mechanical and biological properties almost similar to the native membranes. Human MSCs were able to adhere and engraft on D-HCM better than D-HAM and expanded faster. Ultrastructural observations, crystal violet staining and expression studies showed better structural and functional integrity of hMSCs on D-HCM than D-HAM and control conditions. Conclusion: A common, simple and reliable process of decellularization can generate large number of cell-liberated amniotic scaffolds in lesser time. D-HCM has better efficiency for hMSCs engraftment and proliferation and can be utilized for preparing suitable cell-laden constructs for tissue engineering applications.}, key = {pmid35096189}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Sarwar_2021, title = {Neuropsychiatric systemic lupus erythematosus: a 2021 update on diagnosis, management, and current challenges}, author = {Sobia Sarwar and Alaa S. Mohamed and Sylvette Rogers and Shah T. Sarmast and Saurabh Kataria and Khalid H. Mohamed and Muhammad Zain Khalid and Mohammad Omar Saeeduddin and Saher T. Shiza and Sarfaraz Ahmad and Anum Awais and Romil Singh}, url = {https://www.cureus.com/articles/65863-neuropsychiatric-systemic-lupus-erythematosus-a-2021-update-on-diagnosis-management-and-current-challenges#!/}, doi = {10.7759/cureus.17969}, issn = {2168-8184}, year = {2021}, date = {2021-09-14}, urldate = {2021-09-01}, journal = {Cureus}, volume = {13}, issue = {9}, pages = {e17969}, publisher = {Cureus, Inc.}, abstract = {Patients with systemic lupus erythematosus (SLE) experience neuropsychiatric symptoms. The term neuropsychiatric SLE (NPSLE) is a generic term that refers to a series of neurological and psychiatric symptoms directly related to SLE. In approximately 30% of patients with neuropsychiatric symptoms, SLE is the primary cause (NPSLE), and symptoms manifest more frequently around SLE onset. Neurovascular and psychotic conditions can also lead to NPSLE. Pathogenesis of NPSLE is implicated in both neuroinflammatory and ischemic mechanisms, and it is associated with high morbidity and mortality. After diagnosing and assigning causality, NPSLE treatment is individualized according to the type of neuropsychiatric manifestations, type of the predominant pathway, activity of SLE, and severity of the clinical manifestations. There are many problems to be addressed with regards to the diagnosis and management of NPSLE. Controlled clinical trials provide limited guidance for management, and observational cohort studies support symptomatic, antithrombotic, and immunosuppressive agents. The purpose of this review was to provide a detailed and critical review of the literature on the pathophysiology, diagnosis, and treatment of NPSLE. This study aimed to identify the shortcoming in diagnostic biomarkers, novel therapies against NPSLE, and additional research needs.}, key = {pmid34667659}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Aguilera-Alvarez_2021, title = {The role and efficacy of coenzyme Q10 in the management of erectile dysfunction in a hypertensive male: an interventional study}, author = {Victor H. Aguilera-Alvarez and Bilal Khan Mohammed and Aqsa Fatima and Ankit Patel and Avaniben Patel and Frederick N. Gyabaah and Jobby John and Abbas Iqbal and Sidra Naz and Affan Munir and Ammer Haffar and Muhammad Irfan and Muhammad Hanif}, url = {https://www.cureus.com/articles/69975-the-role-and-efficacy-of-coenzyme-q10-in-the-management-of-erectile-dysfunction-in-a-hypertensive-male-an-interventional-study#!/}, doi = {10.7759/cureus.17937}, issn = {2168-8184}, year = {2021}, date = {2021-09-13}, urldate = {2021-09-01}, journal = {Cureus}, volume = {13}, issue = {9}, pages = {e17937}, publisher = {Cureus, Inc.}, abstract = {Introduction: Erectile dysfunction (ED) is a prevalent medical condition that affects millions of men globally. A number of pharmacological and complementary options are used in the management of ED, including Coenzyme Q10 (CoQ10). Oxidative stress has been linked to the progression of ED, and Co Q10 protects against oxidative damages and improves erectile function as well as the activity of antioxidant enzymes. This study aimed to determine the efficacy of CoQ10 in the treatment of erectile dysfunction in hypertensive males. Method: An open-labeled parallel arm interventional study was conducted in the cardiology unit of Hayatabad Medical Complex Hospital, Peshawar, Pakistan, from March 2020 to March 2021. Hypertensive male patients (n = 230) were randomly allocated to either receiving 200-gram CoQ10 daily along with their current antihypertensive therapy (n=104) or anti‐hypertensive treatment only (n=105). The patient’s erectile function was assessed at baseline and three months using the International Index of Erectile Function Test (IIEF-5) during the study period. Result: Of the total 230, 209 (90.87%) patients were included in the final analysis. There were no significant differences in demographics, history of illness, co-morbid conditions, and current medication of both groups. After three months, 21 (20.1%) participants scored more than 17 in the IIEF-5 and no longer had ED. Overall, no significant difference was found in the mean IIEF-5 score between the study group and control group (14.41 ± 4.49 Vs. 15.61 ± 4.82; p=0.06). However, in subgroup analysis, significant improvement in the study group was seen in participants with mild ED (p=0.03). Conclusion: With the demonstration of its efficacy in hypertensive patients with mild ED, co-enzyme Q10 supplementation can be proposed as a potential candidate in patients with long-term hypertension and can play a role in erectile dysfunction.}, key = {pmid34660127}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Begum_2021, title = {Insight of medical students on online teaching during COVID-19 pandemic}, author = {Vaseemunnisa Begum and Neeraj Sadiq and Ghulam Subhani and Syeda Asma Gulnaaz and Mohammed Mohsin and Nageswari Devi}, url = {https://www.ijpp.org.in/journal-article-file/14660}, doi = {10.18231/j.ijpp.2021.033}, issn = {2393-9079}, year = {2021}, date = {2021-09-04}, urldate = {2021-09-04}, journal = {Indian Journal of Pharmacy and Pharmacology}, volume = {8}, issue = {3}, pages = {195-199}, abstract = {Background: The Global disease (COVID-19 pandemic) has impacted our lives in various ways. Online teaching is the strange routine for studying platforms to continue with the process of educating students, Online classes have become a key component in the continuity of education. Aims: 1. This study aims to rank the usefulness of online teaching compared to classroom conventional teaching 2. Socioeconomic parameters related to online teaching in a medical college. Study Design: The study is a cross-sectional study done on medical students. A questionnaire was prepared listing the various ways in which they discern online teaching trying to cope up during the pandemic. Materials and Methods: After the institutional Ethics committee clearance, online cross-sectional study was done on the medical students where from the 2 and 3 year. This online survey was done between 10May 2021- 10 June 2021, A total number of 211 students participated out of 250, after completion of 18 months of online classes. A Set of 15 self -designed questionnaire based on 5 point Likert scale was given to the students to rank the effectiveness through online class usefulness levels and satisfaction levels on various parameters. Students were also asked about the demographic factors. Statistical Analysis: The data was analyzed using software SPSS software. Results: The study results shows that online classes is less helpful in five parameters and equally helpful in five parameters but was not at all superior to conventional methods, we can come to the interpretation that students think that classroom teaching cannot be replaced by online teaching. Conclusions: We can conclude that online studies can only be a supplement and cannot be an alternate for the established order of learning.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Seema_2021, title = {A complicated case of CSOM with sigmoid sinus thrombosis}, author = {Seema and Sana Shayestha Khan and Shaik Wasim Meera and Ahmedi Begum and Imtiaz Ahmed Khan}, url = {https://www.ijsr.net/archive/v10i9/SR21923142228.pdf}, doi = {10.21275/SR21923142228}, issn = {2319-7064}, year = {2021}, date = {2021-09-01}, urldate = {2021-09-01}, journal = {International Journal of Science and Research}, volume = {10}, issue = {9}, pages = {1535-1538}, abstract = {We report a case of sigmoid sinus thrombosis in a clinical setting of Chronic Suppurative Otitis Media (CSOM) in a 16 year old female. She presented with left ear discharge of 7 days duration, associated with left unilateral headache of 1 month duration. Ear Nose and Throat examination revealed total perforation of the tympanic membrane with pinkish mass protruding in the external auditory canal. Further investigations revealed a thrombus (infective) in sigmoid sinus. Left modified radical mastoidectomy was done to completely eradicate the disease and source of infection. The patient was treated with anticoagulants and parenteral antibiotics, based on the culture and sensitivity report. After 5 weeks follow up, patient was found to be asymptomatic.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2021, title = {Serum calcitonin gene related peptide (CGRP) levels in migraine: a study on its clinical correlation and diagnostic efficacy}, author = {Sofia Khatoon and Noorunissa Begum and Hafeeza Sultana and Maryam Rashed and Mohammed Zoheb and Aleem Ahmed Khan and Sara Shreen and Syed Iqbal Ahmed}, url = {https://rjn.com.ro/articles/2021.3/RJN_2021_3_Art-13.pdf}, doi = {10.37897/RJN.2021.3.13}, issn = {1843-8148}, year = {2021}, date = {2021-08-10}, urldate = {2021-08-10}, journal = {Romanian Journal of Neurology}, volume = {20}, issue = {3}, pages = {342-348}, abstract = {Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology. CGRP is multifunctional, and its vasodilating activity within the central and peripheral blood vessels is one in all its primary functions.The intention is to prove serum calcitonin gene related peptide (CGRP) as an early diagnostic tool for migraine and the novelty is to correlate it with characteristics of migraine so that it helps in early initiation of treatment. Methods. 100 subjects including 90 patients with migraine and 10 with non-headache (NH) age-matched controls were prospectively recruited in our current study. The subjects were aged from 15- 50 years. The clinical assessment was made every month for the three months after the start of therapy. The subjects were compared based on the serum CGRP values. Serum CGRP concentrations were measured by using CGRP ELISA kit. Results. Out of total subjects selected, the maximum (23.3%) subjects were between age 26 and 30 years and least effected age group was 46-50 years (4.44%). Females’ predominance with 82% than males with 18%.Stress was major trigger occurring in 57% of cases. Throbbing pain with elevated CGRP levels 130.44±114.22 and p value (p = 0.01). The average CGRP levels was higher in test group 149.00±93.86 compared to control 61.30±24.37 with p value (p = 0.02). Conclusions. The serum CGRP levels were statistically more in migraine patients correlated with characteristics like throbbing type of pain, stress and inadequate sleep. Hence, the serum CGRP levels estimation can be considered as a diagnostic tool for migraine when the clinical character’s over lap or early in the course of migraine when all criteria for diagnosis are not yet fulfilled.}, keywords = {Central Research Laboratory, Deccan School of Pharmacy, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Rafat_2021, title = {Posterior reversible encephalopathy in undiagnosed systemic lupus erythematosus: a rare case report}, author = {Wardah Khalid Rafat and Shah T. Sarmast and Saher T. Shiza and Kehinde Olaleye and Sylvette Rogers}, url = {https://www.cureus.com/articles/65101-posterior-reversible-encephalopathy-in-undiagnosed-systemic-lupus-erythematosus-a-rare-case-report#!/}, doi = {10.7759/cureus.16945}, issn = {2168-8184}, year = {2021}, date = {2021-08-06}, urldate = {2021-08-01}, journal = {Cureus}, volume = {13}, issue = {8}, pages = {e16945}, publisher = {Cureus, Inc.}, abstract = {Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder known to affect the nervous system by direct neuronal damage, vasculitis, or pathologic mechanisms indirectly induced by immune mechanisms related to the production and deposition of immune complexes. SLE has a wide range of clinical manifestations due to the involvement of almost every organ system of the body. SLE presents with serositis, mucositis, arthralgia, glomerulopathy, hematological, cutaneous, and hematological manifestations. Among the neurological manifestations of SLE, posterior reversible encephalopathy is rarely described in the literature. We report a case of posterior reversible encephalopathy in a female patient who presented with seizures, altered mentation, headache, and blurry vision in the setting of undiagnosed SLE.}, key = {pmid34513513}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2021, title = {A prospective study on etiological factors and clinical indicators in term and near term neonates admitted with hyperbilirubinemia in NICU in a tertiary care hospital in Hyderabad, India}, author = {Syed Adnan Ali and C. V. S. Lakshmi and Uppin Narayan Reddy and Farhana Nazneen}, url = {https://www.ijmpo.com/journal-article-file/14451}, doi = {10.18231/j.ijmpo.2021.011}, issn = {2581-4699}, year = {2021}, date = {2021-08-03}, urldate = {2021-08-03}, journal = {IP International Journal of Medical Paediatrics and Oncology}, volume = {7}, issue = {2}, pages = {51-56}, abstract = {Objectives: 1. To study the etiology and risk factors of neonatal hyperbilirubinemia in term and near-term infants. 2. To study the clinical course of these infants during NICU stay. Materials and Methods: The present study was conducted at NICU, Department of Pediatrics, Princess Esra hospital, Deccan Medical College, Hyderabad, India, from October 2019 to October 2020. Term and late preterm infants admitted in NICU with Serum Bilirubin levels more than 12mg/dl were included in the study. The risk factors, etiology and clinical profile of these infants during NICU stay were studied. Results: 210 neonates were admitted in NICU with hyperbilirubinemia (Serum Bilirubin >12mg/dl) during the study period, out of which 118 were male (56.20%) and 92 were female (43.80%). Neonates were further distributed based on gestational age, in which 46 (21.90%) were late pre-terms i.e. between 34-37 weeks and 164 neonates (78.10%) were full term i.e. greater than 37 weeks. The neonates were also classified based on their birth weight, with neonates between 2500-3000 grams having the highest incidence (46.19%). Lastly, the etiological and risk factors were assessed and quantified, with physiological jaundice occurring as the major cause and late prematurity as the most common risk factor associated with neonatal hyperbilirubinemia. The average duration of phototherapy was 2.50 days and 3 babies required Double Volume Exchange Transfusion (DVET) for significant hyperbilirubinemia. None of the babies requiring DVET had clinical features of Bilirubin Induced Neurological Dysfunction (BIND) during NICU stay. Conclusion: 1. Most common cause of neonatal hyperbilirubinemia was found to be Physiological followed by Septicemia and Idiopathic etiologies. Blood group incompatibilities were less common causes. 2. Phototherapy is a cheap and effective way to reduce bilirubin levels in neonatal jaundice. 3. Exchange transfusion is a safe procedure and should be considered when indicated, to decrease the incidence of BIND. All cases requiring DVET were due to blood group incompatibility. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2021, title = {Small airways, big problem: extrafine beclomethasone/formoterol in asthma and chronic obstructive pulmonary disease- a systematic review}, author = {Ashfaq Hasan and Priyanka Mukherjee and Sushmeeta Chhowala and Meena Lopez and Prashant N. Chhajed}, url = {https://journals.lww.com/lungindia/Fulltext/2021/08000/Small_Airways,_Big_Problem__Extrafine.9.aspx}, doi = {10.4103/lungindia.lungindia_394_20}, issn = {0970-2113}, year = {2021}, date = {2021-08-01}, urldate = {2021-08-01}, journal = {Lung India}, volume = {38}, issue = {4}, pages = {350-358}, abstract = {Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases characterized by an inflammatory process that extends from the central to peripheral airways. Conventional pressurized metered-dose inhalers and most dry-powder inhalers emit drug particles too large to target the small airways effectively. Advancements in drug formulation have given rise to a new generation of inhalers that can generate aerosols with extrafine drug particles that leads to more effective aerosol penetration into the lung periphery. An extrafine formulation of inhaled beclomethasone/formoterol (BDP-FF) with enhanced lung deposition is now available. This document reviews the various real-world and controlled studies that have evaluated the efficacy of extrafine BDP-FF in asthma and COPD.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Begum_2021b, title = {Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis}, author = {Nazima Begum and Syed Mohammed Akbar Hassan and Purushottam Padmanabhan and Shaik Iqbal Ahmed and Avinash Bardia and Aleem Ahmed Khan}, url = {https://jmas.in/index.php?mno=49688}, doi = {10.5455/jmas.49688}, issn = {2231-1696}, year = {2021}, date = {2021-07-31}, urldate = {2021-01-01}, journal = {Journal of Medical and Allied Sciences}, volume = {11}, number = {2}, pages = {105-113}, publisher = {Deccan College of Medical Sciences}, abstract = {It has been estimated that 4.4 billion individuals are infected with Helicobacter pylori and the prevalence of the infection varies globally ranging from the highest reported in Africa (70.1%) to lowest in Switzerland (18.9%). The prevalence is still abundant in developing countries and is due to the outcome of low socioeconomic status and poor sanitation. Helicobacter pylori infection is implicated in several pathological states and is confronting a gigantic challenge to the global health community. This review provides an extensive picture of Helicobacter pylori infection prevalence and its association with disease outcomes using myriad sample studies, emphasizing detection using gastric biopsy. Moreover novel molecular mechanisms unveiled to date are also presented to better comprehend the underlying events that triggers the epidemiological effects. Data and mechanistic pathways presented in this review aid in improved regulation of Helicobacter pylori infection and assists in designing and crafting new drugs to treat the associated clinical conditions.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Butul_2021, title = {Onychomadesis, a post infectious sequelae of Hand-Foot-and-Mouth disease: A case report}, author = {Bushra Butul and Neda Fatima and Sumayya Fathima and Mohammed Nazim Uddin}, url = {https://jmas.in/index.php?mno=61243}, doi = {10.5455/jmas.61243}, issn = {2231-1696}, year = {2021}, date = {2021-07-31}, urldate = {2021-01-01}, journal = {Journal of Medical and Allied Sciences}, volume = {11}, number = {2}, pages = {183-185}, publisher = {Deccan College of Medical Sciences}, abstract = {Onychomadesis is an idiopathic shedding of a proximal part of the nail as a result of the temporary suspension of a nail matrix function. It is seen in fingernails, toenails, or both. Various underlying causes like systemic illness, drug reactions, Viral diseases, and bullous diseases have been associated with Onychomadesis. However, the mechanism of any such association remains unclear. Here we present a case of Onychomadesis and Beau lines in the fingernails of a 13-month-old girl following Hand, foot, and mouth disease.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2021c, title = {Validation of the new international league against epilepsy 2017 classification for determining seizure type in Indian patients}, author = {Sandhya Manorenj and Navya Sagari}, url = {https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-1731934.pdf}, doi = {10.1055/s-0041-1731934}, issn = {2213-6320}, year = {2021}, date = {2021-07-20}, urldate = {2020-07-20}, journal = {International Journal of Epilepsy}, volume = {7}, pages = {29-35}, abstract = {Introduction Epilepsy is a common condition in neurology comprising several electroclinical syndromes and seizure disorders of varying known and unknown etiologies that require variable diagnostic workup, treatment, and have obviously different prognoses. Therefore, for appropriate patient management, the best possible classification system for epilepsy is required. The International League Against Epilepsy (ILAE) is continuously working on this with the latest classification provided in 2017. There is little knowledge about seizure type based on newer classification systems in Indian patients. Aims and Objective To test the applicability of the newer ILAE 2017 classification of epilepsy in determining seizure type in Indian patients, with respect to right patient management, the best classification system for epilepsy is necessary. Materials and Methods: Prospective data of 310 consecutive patients with seizures presenting in neurology department was collected from December 2017 to June 2018 and analyzed according to the newer systems of classification of seizures proposed by ILAE in 2017. Results All 310 patients in age ranging from one year to 72 years with seizures could be classified according to the ILAE 2017 classification system. Focal onset seizure was noted in 66 patients (21.3%), while 244 patients (78.7%) had generalized onset based on clinical onset of seizure. Awareness was impaired in 262 (84.5%) patients. Motor onset seizure was observed in 278 patients (89.6%), while nonmotor seizure included absence, sensory, cognitive, and autonomic seizures. Conclusion The present study showed that all patients could be classified using ILAE 2017 classification system. Majority of seizure were generalized onset, predominantly motor type of seizure with impaired awareness using clinical description of classifying seizure, while focal onset seizure was the majority type of seizure when ancillary information was considered.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2021, title = {Clinical efficacy, safety, and tolerability of dual versus single antiplatelet therapy in acute ischemic cerebrovascular disease with lacunar stroke in Indian patients. One year prospective study with outcome assessed at 90 days }, author = {Sandhya Manorenj and Srikant Jawalkar}, url = {https://bcn.iums.ac.ir/article-1-1972-en.html}, doi = {10.32598/bcn.12.4.2973.1 }, issn = {2008-126X}, year = {2021}, date = {2021-07-19}, urldate = {2021-07-19}, journal = {Basic and Clinical Neuroscience}, volume = {0}, issue = {0}, abstract = {Introduction & Background: Lacunar stroke, comprising 18% of Ischemic stroke, is the second most common subtype of stroke in India. Available data on the effect of dual antiplatelets treatment with aspirin plus clopidogrel vs single antiplatelet therapy with aspirin alone and their doses in Lacunar stroke happens to be very limited. Aim: The aim of our study was to decipher the efficacy, safety & tolerability of dual versus single antiplatelet therapy in the treatment of patients with recent occurrence of lacunar stroke. Materials & Methods: It was a prospective, single centre study conducted at the Department of Neurology. Patients with recent occurrence of Lacunar stroke were randomly divided into 4 groups to receive Aspirin 150 mg (Group1), Aspirin 150 mg plus clopidogrel 75 mg (Group 2), aspirin 75mg plus clopidogrel 75 mg (Group 3), and aspirin 75 mg (Group 4) once daily and were closely monitored for 90 days. Results: 360 patients were recruited and followed for 90 days. Mean age of the patients was 57.8 ±14.1 years. 188 patients (52.2%) were males. Recurrence of Ischemic stroke occurred highest in group 4 (22%) with no recurrence in group 2 .Comparisons of recurrence of Ischemic stroke between group 1 and group 4 (95% CI: 2.6829% to 31.73551%) and between group 3 and group 4 (95% CI: 3.9439% to 32.1542%) showed a statistically significant value <0.05. Haemorrhagic events occurred among recipients on dual antiplatelets therapy. Conclusions: Efficacy wise, Group 2 with 150 mg aspirin plus 75 mg clopidogrel, was found superior to other groups in the prevention of Lacunar stroke. Groups with dual antiplatelet therapy manifested a worrisome thread of bleeding events. }, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2021c, title = {Heart failure outcomes in patients with and without renal impairment}, author = {Faizah Khan and Tayseen Sultana and Syeda Hafsa and Hafsa Anjum and Rajashekar Reddy Gurrala and Abhishek Golla and Azmath Unnisa Begum}, url = {https://journalajcr.com/index.php/AJCR/article/view/69/139}, year = {2021}, date = {2021-07-16}, urldate = {2021-07-16}, journal = {Asian Journal of Cardiology Research}, volume = {4}, issue = {1}, pages = {205-218}, abstract = {Aims:To evaluate the differences in clinical characteristics, management patterns and outcomes in acute heart failure patients with and without renal impairment.Study Design: Prospective observational study.Place and Duration of the Study: Department of Cardiology, Princess Esra Hospital, Telangana, Hyderabad, from August 2019 to January 2021.Methods: We included 127 acute heart failure patients who were divided into two groups based on their renal function: group I having GFR >60ml/min (normal renal function) and group II having GFR ≤60ml/min (renal impairment).Subjectivedata, objective parameters and management patterns of patients were recorded during the hospital stay and the outcomes (improvement in NYHA class, readmissions and mortality) were assessed at follow up.Results:Among atotal of 127 patients; 62 patients had a LVEF <40% (HFrEF),38 patients had a LVEF 40-49% (HFmEF) and 27 patients had a LVEF ≥50% (HFpEF).The prevalence of renal impairment was found to be more in acute heart failure patients with preserved EF (77.7%). Patients in group II were less likely to receive ACEIs/ARBs (P=0.0010) and digoxin (P=0.001) and more likely to receive H+ISDN (P=0.0001).The mortality in group II patients was significantly more when compared to group I patients at the end of 1 year follow up (41.46% vs 13.33%;P=0.001). Group ll also showed less clinical improvement in NYHA class(32.92% vs 46.66%;P=0.12) at the end of 1 year follow up.Conclusion: AHF patients with renal impairment had higher mortality at one year. In this study glomerular filtration rate was a stronger predictor of mortality than left ventricular ejection fraction. There was significant underutilization of important heart failure therapies in patients with renal impairment. Future clinical trials are suggested to validate benefits of disease modifying therapies (H+ISDN) and newer drugs (ARNIs, SGLT2 inhibitors) in patients with renal impairment.}, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @inbook{Nasirabadi_2021c, title = {COVID 19 Pandemic and Telemedicine Practice in India}, author = {Minhajzafar Nasirabadi and V. George Reddy and Vishal Akula}, editor = {Arabinda Brahma and George V. Reddy and Sujit Sarkhel}, url = {https://deemagclinic.com/2021/12/07/parallel-pandemic-of-2020/}, isbn = {9798772377505}, year = {2021}, date = {2021-07-12}, booktitle = {Parallel Pandemic of 2020}, pages = {56-70}, publisher = {Indian Psychiatric Society}, address = {Gurugram}, edition = {1st}, chapter = {5}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {inbook} } @article{Ur_Rahman_2021, title = {Prevalence and temporal trends of anemia in patients with heart failure}, author = {Ebad Ur Rahman and M. D. Chobufo and Farah Fatima and T. Mohamed and M. Elhamdani and C. Rueda and W. S. Aronow and G. C. Fonarow and E. Thompson}, url = {https://watermark.silverchair.com/hcab193.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA1YwggNSBgkqhkiG9w0BBwagggNDMIIDPwIBADCCAzgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMW521EqKgcybAzMoNAgEQgIIDCWcFaOJIlHXjAtRRPiwqCrglAHWa8_4vcpGmQ1_DLPY-M1G8UfR81hKwOwPs6sccmF6ApWy63-G8m_idafTcus4HNzHGT2UZdqKsMhwlKo7eccP89F0fzS7bAowdU8lH1HbUYIrcUKT5IFajZfq5rX9X4nxGAlKoC-mfYTdrw_qaWGhhWURXKhCSvpwRKcgWlL607Z_XOzPB1RZcM43XWWRdzrAfa2ICzb85-d7XETmbFdChMS6FeNp3LYyhxp24M92to9x27imcDDjeJXUeK76Lp1LH_fqMa8_4B_OAVMooTSd3rYwWu-2ugQLscEGfMdm8DNYKQT51aXmmVpjQesZwRs2RvtL9D-tZFYrSkger4k4W8xjinUvR5j6vR57LGPe3bGThEIZWJRPYkhCWwazsbwJvIr_1Y3BX4TzoXcLi96nV6hwrJTqiryGVYvJf_tdYZ2JeIGYxlCeOwH_TeOo-XLqzsBFtg5FSf8eYSTOUNm38efNYNG8vHL6J6scrt1gq-J0rWpFgr5-aHp3eDyUlZrOr0dyVesomCkaYgDYv1ABzlmnQ_v9sxAuJigjPk_U_YZWzK9puQQgWRGhfUaKh_7kK8cq9d470HQJs9GJG7UJO78PxL6L-ZlRhSj9ZXn2tvpZZkchmyhEjevcYZwGHhLlDEsyjFeWliSfvgbmfwDeyn0Np2ZrR1K8I99KQhyvJQMPiXcXXjLDpFhUNqu-5_scgRwGFsNrroLMxSFixh8vIaWuDQwt9qqyuisxk5fS-XyaAhnduTtM9knt5677ZXY7ZWekQClQeA0RYS6YZfXJo4Dv8YW4MmnZIUJR1S9j2Xvjt1xidyPbcgzaBQ9-RO09JYKmrxgrwOwrNbbrEXIWGYy03xGDtZiAIRKiA5aUorDp-6iA_-1v-DJ7FgJ4m0jM1IJXV71PViP_JqmgM0ThwsLZ5dRGQ0wypJlaBYU__amxkwox1co1zdvw6yazR6vMSAoIgdu-y63hOcCpXTmYL9om47bJqbYndrr95WSMx4qzCSrDzCg}, doi = {10.1093/qjmed/hcab193}, issn = {1460-2393}, year = {2021}, date = {2021-07-09}, urldate = {2021-07-09}, journal = {QJM: An International Journal of Medicine}, volume = {115}, issue = {7}, pages = {437-441}, publisher = {Oxford University Press (OUP)}, abstract = {Background: Anemia is an important comorbidity in heart failure (HF), and it is associated with increased adverse disease experience and mortality. Previous reports have focused mainly on HF presenting in healthcare settings. We, therefore, set out to establish the nationwide prevalence and temporal trends of anemia in community-based patients with HF in the US. Aim: To establish the nationwide prevalence and temporal trends of anemia in community-based patients with HF in the US. Design: The NHANES dataset, conducted by the CDC National Center for Health Statistics was used to collect nationally representative data on the health and nutritional status of the non-institutionalized US population. Methods: We utilized the National Health and Nutrition Examination data collected over five survey cycles (2007–16). Included were participants aged 20–80 years with self-reported diagnosis of HF. Anemia was defined using 2 sex specific cut offs of 13 and 12 g/dl (cutoff 1), and 12 and 11 g/dl (cutoff 2), for men and women, respectively. The Chi square test was used to compare prevalence across different categories and survey cycles. Data analysis was done using STATA 16 with P-values < 0.05 considered statistically significant. Results: The median hemoglobin in all HF patients was 13.5 g/dl (IQR 12.4–14.5). The prevalence of anemia among community-based patients with HF in the US was 21.34% (cutoff 1) and 9.03% (cutoff 2) and has been stable from 2007 to 2016. The burden of anemia was disproportionately higher in NH Blacks (34.48%, 95% CI 27.12–42.67) and those with BMI < 25 Kg/m2 (17.4%, 95% CI 10.9–26.64). Conclusion: The prevalence of anemia in patients with HF in the US is at least 9% and has remained stable over the past decade. This high persistent burden with limited proven interventions should spur further efforts aimed at identifying impactful ways of addressing anemia in patients with HF.}, key = {pmid34264349}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Asfiya_2021, title = {Role of eosinophil count for early recognition and prognostication of Covid-19}, author = {Khanam Asfiya and Syed Mohammed Ali Mehdi and Idrees Akhtar Afroze and Fawwad M. Shaikh and Sumayya Begum and Nabila Afsar}, url = {https://www.ijmsir.com/asset/images/uploads/16281658002972.pdf}, issn = {2458-868X}, year = {2021}, date = {2021-07-01}, urldate = {2021-07-01}, journal = {International Journal of Medical Science and Innovative Research}, volume = {6}, issue = {4}, pages = {224-232}, abstract = {Background: The Severe Respiratory Distress Syndrome caused by the COVID-19 virus has turned into a pandemic and has caused havoc worldwide and is still continuing to do so. In such times, there is a need for a diagnostic tool which eases the technique of detecting the disease and is also less time consuming. Thus an analogy was established between the Covid-19 positive RT-PCR cases and their blood eosinophil levels. Aims: To study the diagnostic and Prognostic significance of eosinophil counts in Covid-19 infections. Settings and Design: This study that was conducted in a tertiary health care centre was done by analysing the eosinophil counts of the patients and there by correlating them with the progression of the disease. Materials and Methods: 105 Patients who tested positive by RT-PCR for COVID-19 were enrolled for this study and their complete blood count report was obtained. Statistical Analysis: The data analysis was done in proportions and percentages. The statistical test of significance applied manually to the cross table was chi square test. Result: Based on the outcome it was noted that 70.50% cases were eosinopenic on admission. Also drop in eosinophil count(93.75% of the cases) or the absence of eosinophils on presentation correlated with poor prognosis. Conclusion: Eosinopenia can help in early detection of Covid-19 infection and the variation in the eosinophil count can help in gauging the prognosis and the outcome of the disease.}, keywords = {Community Medicine, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2021b, title = {Schwannoma of the floor of the mouth}, author = {Alina Khan and Uzma Mujtaba and Shereen Zainab and Momin Shakeeb and Priyanka Singh and Urooj Ahmed Choudhary}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/schwannoma-of-the-floor-of-the-mouth_July_2021_5608273514_2827882.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2021}, date = {2021-07-01}, urldate = {2021-07-01}, journal = {International Journal of Scientific Research}, volume = {10}, issue = {7}, pages = {73-74}, abstract = {Schwannoma is a benign neoplasm comprising solely of Schwann cells. Etiology of schwannoma is unknown. It mostly presents as an asymptomatic solitary mass,with surface being smooth and consistency being firm and having a slow growth rate. Age of presentation usually ranges from 30 to 50 years. Though it is uncommon, about 25% present in the head and neck region with schwannoma in the floor of the mouth being quite rare. Here is a case of Schwannoma of the floor of the mouth in a 13-year-old female. }, keywords = {Otorhinolaryngology, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{AbdurRaheem_2021, title = {Chronic calculous cholecystitis: reasons to consider advanced laparoscopic surgery}, author = {Juwairiah Abdur Raheem and Suresh Chandra Annu}, url = {https://ijcp.in/Admin/CMS/PDF/IJCP%20June%202021.pdf}, issn = {0971-0875}, year = {2021}, date = {2021-06-30}, urldate = {2021-06-30}, journal = {Indian Journal of Clinical Practice}, volume = {32}, issue = {1}, pages = {20-26}, abstract = {Background: Laparoscopic cholecystectomy (LC) has been a basic laparoscopic procedure performed mostly by a general surgeon without a multidisciplinary team (MDT) setup. In cases of chronic calculous cholecystitis (CCC), surgeons are faced with greater challenges. Objective: To critically evaluate the parameters which are likely to be associated with increased morbidity in patients undergoing LC for CCC. Material and methods: Information on patients aged more than 15 years who underwent elective LC for gallbladder stone disease from February 2016 to December 2019 was collected and those diagnosed as CCC were analyzed in detail. Results: Chronic calculous cholecystitis was seen in 37.32% of all cases diagnosed as gallbladder stone disease and 6.17% cases were associated with complications. Conclusion: Cases of CCC undergoing elective LC are best managed under MDT and need to be placed under advanced laparoscopic surgery.}, keywords = {Surgical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2021, title = {Abdominal cocoon: a diagnostic puzzle, multiple causes similar presentation– experience with 38 cases in search of a reliable imaging sign}, author = {G. Raghavendra Prasad and J. V. Subba Rao and Mahera Naureen and Gayatri Reddy Danda}, url = {https://journals.lww.com/kesg/fulltext/2021/27010/abdominal_cocoon__a_diagnostic_puzzle,_multiple.4.aspx}, doi = {10.4103/ksj.ksj_5_21}, issn = {0973-3051}, year = {2021}, date = {2021-06-30}, urldate = {2021-06-30}, journal = {Kerala Surgical Journal}, volume = {27}, issue = {1}, pages = {8-12}, abstract = {Introduction: There are varied causes for abdominal cocoon. This study aims to present the varied causes of abdominal cocoon and definite pre operative indicator if any. Materials and Methods: A retrospective analysis of 38 cases of abdominal cocoon formed the cohort. An attempt was made to compare with the published cases of abdominal cocoon. Results: Giant cystic meconium peritonitis and para duodenal hernias were the most common non tubercular acute abdomen in children. Tubercular cocoon, cerebrospinal fluid CSF pseudocyst, ruptured ovarian cyst and idiopathic nonspecific sclerosing peritonitis were other causes. Imaging analysis showed clustering of bowel loops and well defined sac were the most reliable predictors. A comprehensive review of 38 cases of abdominal cocoon showed clustering of the bowel loops as the most reliable preoperative indicator of abdominal cocoon. Conclusions: Though there are varied causes for abdominal cocoon, clustering of bowel loops and well defined sac were the most reliable predictors. }, keywords = {Anesthesiology, General Surgery}, pubstate = {published}, tppubtype = {article} } @inbook{Mukheem_2021, title = {Bio-plastic polyhydroxyalkanoate (PHA): Applications in modern medicine}, author = {Abdul Mukheem and Syed Shahabuddin and Aleem Ahmed Khan and Md. Murad Hossain and Ainil Hawa Jasni and Nanthini Sridewi}, editor = {Mohammed Kuddus and Roohi}, url = {https://link.springer.com/chapter/10.1007/978-981-16-1823-9_8}, doi = {10.1007/978-981-16-1823-9_8}, isbn = {9789811618239}, year = {2021}, date = {2021-06-22}, urldate = {2021-01-01}, booktitle = {Bioplastics for Sustainable Development}, pages = {231-257}, publisher = {Springer Singapore}, chapter = {8}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {inbook} } @article{Prasad_2021c, title = {Status of vitamin D receptor gene polymorphism and 25-hydroxy vitamin D deficiency with essential hypertension}, author = {M. Prasad and D. Rajarajeswari and P. Aruna and K. Ramalingam and R. Viswakumar and Nusrath Fathima and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan}, url = {https://link.springer.com/content/pdf/10.1007/s12291-021-00984-z.pdf?pdf=button}, doi = {10.1007/s12291-021-00984-z}, issn = {0974-0422}, year = {2021}, date = {2021-06-15}, urldate = {2021-06-01}, journal = {Indian Journal of Clinical Biochemistry}, volume = {37}, issue = {3}, pages = {335-341}, publisher = {Springer Science and Business Media LLC}, abstract = {Essential hypertension (EH) is a multifactorial and complex disease with high rate of incidence and associated co-morbidities. Previous studies do not provide unanimous results for the risk of hypertension and association with Fok I genotype frequency and serum vitamin D levels. Hence, this study was undertaken to determine the status of Fok I vitamin D receptor (VDR) gene polymorphism along with vitamin D levels and blood pressure in patients with EH. Four hundred (200 controls and 200 cases of essential hypertension) participants from general Indian population were enrolled in this study. Peripheral blood samples were collected for genotyping Fok I-VDR gene polymorphism using PCR–RFLP method whereas 25-OH vitamin D levels in serum were quantified using high performance liquid chromatography (HPLC). Significantly reduced 25-OH vitamin D levels were observed in patients with EH (24.04 ± 8.62 vs 50.46 ± 15.46) compared to control subjects (p = 0.0001). Homozygous recessive genotype ‘ff’ frequency was increased by 8.06 fold (CI: 3.71–17.47}, key = {pmid34149207}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2021, title = {Role of platelet-WBC ratio as a prognostic marker of cerebrovascular accident}, author = {Syed Arshad Hussain and Atiya Begum}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-plateletwbc-pwr-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_June_2021_6700252511_2520939.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2021}, date = {2021-06-01}, urldate = {2021-06-01}, journal = {International Journal of Scientific Research}, volume = {10}, issue = {6}, pages = {24-25}, abstract = {Cerebrovascular accidents are a leading cause of patient morbidity and mortality worldwide. The symptoms include sudden loss of vision,unconsciousness,weakness in contralateral upper and lower limbs, seizures and loss of vision. Several studies have concluded that the lower the platelet count and the higher the number of white blood cells in ischemic stroke patients will result in a more severe stroke and had worsen prognosis. Platelet and white blood cells counts can be converted into Platelet-to-White Blood Cell Ratio (PWR) which is a comparison between the number of platelets and white blood cells, so the higher PWR will provide better clinical outcomes. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Tiwari_2021, title = {Efficacy and safety of neural stem cell therapy for spinal cord injury: a systematic literature review}, author = {Santosh Tiwari and Shaswati Khan and Shiva V. Kumar and Rohit Rajak and Asma Sultana and Shaik Abjal Pasha and Divya Gauba and Pinaki Ghosh and Tanu Khurana and Aishwarya Kulkarni and Yugandhar P. Reddy and Aleem Ahmed Khan and Varun Kumar Sharma}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0040595720301165?via%3Dihub}, doi = {10.1016/j.therap.2020.06.011}, issn = {0040-5957}, year = {2021}, date = {2021-05-29}, urldate = {2021-05-01}, journal = {Therapies}, volume = {76}, issue = {3}, pages = {201-210}, publisher = {Elsevier BV}, abstract = {Aims: To summarize the evidence on the efficacy and safety of neural stem cell therapy (NSCT) for the treatment of spinal cord injury (SCI). Methods: A systematic literature review of Medline®, EMBASE® and Cochrane library was performed to identify studies reporting efficacy and safety of NSCT in SCI. Articles were included if they reported efficacy and safety data of SCI patients who received NSCT. Results: Overall, four studies of the 277 records met all the study eligibility criteria. Over the 1-year follow-up period, motor scores were significantly higher among patients who received NSCT compared with those who did not (American Spinal Injury Association [ASIA] motor scores (mean ± standard deviation [SD]): 7.9 ± 1.2 versus 3.9 ± 0.6; upper extremity motor score: 7.8 ± 2.1 versus 3.9 ± 0.6, both P < 0.05). Sensory scores (pinprick score: 4.8 ± 1.3 versus 2.9 ± 0.6; P = 0.5; light touch score: 6.9 ± 3.1 versus 2.3 ± 0.5, P = 0.3), ASIA impairment scale (26% versus 7%) or pain score (baseline: 2.4 ± 0.6; 1-year: 3.4 ± 0.4) were comparable in both NSCT and non-NSCT cohorts. Over the 1-year follow-up period, the graded redefined assessment of strength, sensibility, and prehension and international standards for neurological classification of SCI scores showed a mean improvement of 14.8 and 17.8 points respectively. Overall, treatment with NSCT showed favorable safety and tolerability profile. Conclusions: Due to the limited and poor-quality evidence, it is too early to make robust conclusions on the efficacy of NSCT in the treatment of SCI. However, based on the included studies, NSCT seems to be a potential option worth exploring among patients with SCI. Nonetheless, prospective, randomized trials in larger cohorts are needed to validate the efficacy and safety of NSCT in the treatment of SCI.}, key = {pmid32709426}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Fareedullah_2021, title = {Evaluation of antibiotic usage in skin and soft-tissue infections and its antimicrobial susceptibility testing: a hospital-based cross-sectional study}, author = {Mohammed Fareedullah and Zareen Unnisa and Shajiya Khan and Fakeha Fatima and Afifa Khan and Syed Nusrath Farees and Mohammed Khaleel}, url = {https://www.jhrr.org/temp/JHealthResRev8127-1805027_050050.pdf}, doi = {10.4103/jhrr.jhrr_34_20}, isbn = {2394-2010}, year = {2021}, date = {2021-05-29}, urldate = {2021-05-29}, journal = {Journal of Health Research and Reviews}, volume = {8}, issue = {1}, pages = {27-33}, abstract = {Aim: To evaluate the antibiotic usage in skin and soft-tissue infections (SSTIs) and to study the sensitivity pattern of identified microorganisms from antimicrobial susceptibility testing (AST) data. Materials and Methods: This was a cross-sectional study carried out in the Inpatient Department of General Surgery at Owaisi Hospital & Research Center, Hyderabad, for 6 months to collect 50 swab samples aseptically from the subjects with diverse SSTIs at the day of admission before the administration of antibiotics, and AST was done using Kirby Bauer disc diffusion method based on the guidelines of Clinical Laboratory Standard Institute (CLSI). Results: Of the 50 swab samples, 43 were culture positive and 7 were culture negative, and the highest number of cases was of cellulitis (14.28%). The most commonly isolated pathogen was Staphylococcus aureus (30.23%). On the basis of antibiotic sensitivity testing, we found that Ciprofloxacin was the most potent drug, followed by Ceftriaxone and Amikacin, for overall bacterial isolates. In our study, the treatment adhered to IDSA guidelines in 50% of cases and we found that many antibiotics were resistant. In cases of gangrene and abscess, a striking deviation from the guidelines (60% and 77.7%, respectively) was seen. Conclusion: This study guided us toward an appropriate treatment plan for the management of some SSTIs. The disproportionate and tedious use of antibiotics should be abstained as this may drive the evolution of resistant microorganisms that are even more difficult to get rid of.}, keywords = {Deccan School of Pharmacy, General Surgery, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Khurram_2021, title = {Urinary ascites in a neonate with posterior urethral valve}, author = {Mir Sumsam Ali Khurram and C. V. S. Lakshmi and Farhana Nazneen and Mohammed Uzair Khan}, url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/4201/2731}, doi = {10.18203/2349-3291.ijcp20212062}, issn = {2349-3283}, year = {2021}, date = {2021-05-25}, urldate = {2021-05-25}, journal = {International Journal of Contemporary Pediatrics}, volume = {8}, issue = {6}, pages = {1125-1127}, abstract = {Urinary ascites in a newborn is an extremely rare condition, most commonly due to posterior urethral valves, due to transmission of high intravesical pressure to calyceal fornices, and subsequent urinary ascites either by calyceal perforation or filtration through walls of urinary tract and their rupture. We describe a newborn male baby, who presented with huge abdominal distension at birth, and diagnosed as urinary ascites on paracentesis. Baby was asphyxiated and required resuscitation at birth, and ventilatory support for 4 days in v/o significant abdominal distension. Micturating cystourethrogram (MCUG)and magnetic resonance imaging (MRI)showed posterior urethral valves. Baby also had a left sided urinoma and grade 4 vesicoureteral reflux (VUR)on MCUG. Post paracentesis and drainage of 400ml of ascetic fluid, and urinary catheterization, baby had significant improvement of deranged renal parameters, and diuresis, and could be weaned from ventilation. In v/o inability to negotiate a urethroscope, a vesicostomy was done for urinary drainage and fulguration of valves planned on follow-up.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2021, title = {A questionnaire based study-assessment of knowledge, attitude and practice of pharmacovigilance among health care professionals-pre and post educational intervention}, author = {Husna Fatima and Ghulam Subhani and Mohammed Mohsin and Nageswari Devi}, url = {https://www.ijbcp.com/index.php/ijbcp/article/view/4661/3201}, doi = {10.18203/2319-2003.ijbcp20212070 }, issn = {2279-0780}, year = {2021}, date = {2021-05-25}, urldate = {2021-05-25}, journal = {International Journal of Basic & Clinical Pharmacology}, volume = {10}, issue = {6}, pages = {638-642}, abstract = {Background:Pharmacovigilance (PV) is an important tool in generating adverse drug reaction (ADR) data. However, the practice of PVis still very low among health care professionals due to lack of knowledge and awareness. This study was conducted to assess the level ofknowledge, awareness and practice of PVamong health care professionals and to assess subsequent change in these after PVtraining session.Methods:A cross sectional questionnaire based study was conducted among health care professionals of a tertiary health care and teaching institute. Participants were given a questionnaire. They completed it before and after undergoing training programme in PV. Impact of effectiveness of educational intervention (continuing medical education CME (pharmacovigilance workshop) was evaluated by paired t-test. Results:Out of 110 participants, 96 participants completely filled the questionnaire before and after the educational intervention(CME). CME on PVwas found to increase knowledge and positive attitudes towards various aspects of PV.Conclusions:Training programme on PV will help increase the knowledge as well as awareness about principles and techniques of PVand improve the rate of spontaneous ADR reporting. Organising frequent CME programmes and workshops will increase the credibility of health care in the country.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Zahid_2021, title = {Trends, predictors, and outcomes of major bleeding after transcatheter aortic valve implantation, from national inpatient sample (2011–2018)}, author = {Salman Zahid and Waqas Ullah and Muhammad Usman Khan and Sakina Abbas and Mian Tanveer Ud Din and Muhammad Faisal Uddin and Arslan Inayat and Aamer Ubaid and Fnu Salman and Samarthkumar Thakkar and Amr Salama and Muhammad Zia Khan}, url = {https://www.tandfonline.com/doi/abs/10.1080/14779072.2021.1924678}, doi = {10.1080/14779072.2021.1924678}, issn = {1477-9072}, year = {2021}, date = {2021-05-20}, urldate = {2021-05-01}, journal = {Expert Review of Cardiovascular Therapy}, volume = {19}, issue = {6}, pages = {557-563}, publisher = {Informa UK Limited}, abstract = {Introduction: Major bleeding remains one of the most frequent complications seen in transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate outcomes, trends, and predictors of major bleeding in patients undergoing TAVI. Methods: We utilized the National Inpatient Sample (NIS) data from the year 2011 to 2018. Baseline characteristics were compared using a Pearsonχ2 test for categorical variables and Mann–Whitney U-Test for continuous variables. A multivariable logistic regression model was used to evaluate predictors of major bleeding. Propensity Matching was done for adjusted analysis to compare outcomes in TAVI with and without major bleeding. Results: A total of 215,938 weighted hospitalizations for TAVI were included in the analysis. Of the patient undergoing the procedure, 20,102 (9.3%) had major bleeding and 195,836 (90.7%) patients did not have in-hospital bleeding events. Patients in the major bleeding cohort were older and had greater female gender representation. At baseline patients with thrombocytopenia (Odds Ratio [OR], 1.47[confidence interval (CI), 1.36–1.59]), colon cancer (OR, 1.70[CI, 1.27–2.28]), coagulopathy (OR, 1.17[CI, 1.08–1.27]), liver disease (OR, 1.31[CI, 1.21–1.41]), chronic obstructive pulmonary disease (OR, 1.29[CI, 1.25–1.33]), congestive heart failure (OR, 1.12[CI, 1.08–1.16]), and end-stage renal disease (ESRD) (OR, 1.47[CI, 1.38–1.57]) had higher adjusted rates of major bleeding. The percentage of adjusted in-hospital mortality (14.4% vs. 4.2%, P < 0.01) was significantly higher in the major bleeding group Patients with major bleeding had higher median cost of stay ($235,274 vs. $177,920) and length of stay (7 vs 3 days). Conclusion: In conclusion, we report that mortality is higher in patients with major bleeding and that baseline comorbidities like ESRD, liver disease, coagulopathy and colonic malignancy are important predictors of this adverse event.}, key = {pmid33926363}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Menon_2021, title = {Efficacy of daratumumab-based regimens compared to standard of care in transplant-eligible multiple myeloma: a meta-analysis}, author = {Trishala Menon and Saurabh Kataria and Ramesh Adhikari and Hira Khan and Muhammad Zain Khalid and Mohammad Omar Saeeduddin and Shafaq Taj and Usama Rehman and Aysun Tekin and Romil Singh}, url = {https://www.cureus.com/articles/58276-efficacy-of-daratumumab-based-regimens-compared-to-standard-of-care-in-transplant-eligible-multiple-myeloma-a-meta-analysis#!/}, doi = {10.7759/cureus.15098}, issn = {2168-8184}, year = {2021}, date = {2021-05-18}, urldate = {2021-05-01}, journal = {Cureus}, volume = {13}, issue = {5}, pages = {e15098}, publisher = {Cureus, Inc.}, abstract = {Daratumumab (dara) belongs to a class of monoclonal antibodies that target CD38 receptors expressed on multiple myeloma (MM) cells. It was first approved for MM treatment in 2015. The efficacy and safety of dara have been reported in many studies. In this analysis, we assessed the outcome of dara addition to standard of care for transplant-eligible newly diagnosed (ND) MM. We conducted a comprehensive search using PubMed, ClinicalTrial.gov, and Embase. Out of 435 articles, we included two randomized clinical trials. We computed the odds ratio (OR) of response rates and risk ratio (RR) of adverse effects using Cochrane RevMan version 5.4. A total of 1,292 patients were enrolled in both trials. The patients were randomized into the control group and the dara group. The dara group included 647 patients and the control group included 645 patients. The CASSIOPEIA trial reported the outcomes using dara, bortezomib (V), thalidomide (T), and dexamethasone (d) versus VTd. The GRIFFIN trial underlined the efficacy of dara, lenalidomide (R), and Vd in the dara group versus RVd in the control group. A pooled analysis of included studies showed an increased overall response rate (OR: 1.60; 95% CI: 1.06-2.41; p = 0.02; I2 = 65%), stringent complete response (OR: 1.59; 95% CI: 1.24-2.05; p = 0.03; I2 = 0%), and negative status for minimal residual disease (OR: 2.47; 95% CI: 1.97-3.10; p < 0.01; I2 = 66%) in the dara group as compared to the control group. However, an increased risk of neutropenia (RR: 1.80; 95% CI: 1.60-2.03; p < 0.01) and decreased risk of peripheral neuropathy (RR: 0.92; 95% CI: 0.86-0.99; p = 0.02; I2 = 52%) were observed in the dara group. Dara addition to the standard of care regimen for transplant-eligible NDMM has promising outcomes with increased efficacy and safety profile and manageable toxicity.}, key = {pmid34155463}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2021, title = {A comparative study of dacryocystorhinostomy with or without stenting in a teaching hospital}, author = {Imtiaz Ahmed Khan and Mohammed Naseeruddin Mujahid and Nabeel Abdul Samad Mulla}, url = {https://www.jebmh.com/abstract/a-comparative-study-of-dacryocystorhinostomy-with-orrnwithout-stent-in-a-tertiary-teaching-hospital-of-telangana-77779.html}, issn = {2349-2562}, year = {2021}, date = {2021-05-17}, urldate = {2021-05-17}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {8}, issue = {20}, pages = {1532-1537}, abstract = {BACKGROUND: Epiphora is a common annoying symptom, embarrassing the patient both socially and functionally and may even endanger the eye. Chronic Dacryocystitis is the most common cause of epiphora which arises from nasolacrimal duct occlusion. Dacryocystorhinostomy (DCR) is the procedure of choice in the management of Dacryocystitis. We wanted to study the final outcome following endonasal DCR for chronic dacryocystitis with or without using silicon stent, evaluate the causes of persistence of epiphora in patients with or without the use of lacrimal stents and identify the methods of overcoming them postoperatively. METHODS A case control study to compare the results of Endonasal DCR with and without stent was conducted among 96 patients of both genders aged above 20 years with symptoms and signs suggestive of nasolacrimal duct blockage. All the cases and controls were randomly selected and included as group A and group B. RESULTS 96 patients were included in this study and they were divided into two groups (Group A and Group B) with 48 patients in each group. More than 75 % of the patients were between 31 and 60 years of age with a mean age of 44.36 ± 3.15 years. In Group B, 72.91 % of the cases were between 31 and 60 years of age with a mean age of 45.50 ± 4.10 years. There was no statistically significant difference in both groups. In group A (DCR with stent) success rate or relief of symptoms was 96 % whereas in group B (DCR without stent) success rate or symptomatic relief was 80 %. CONCLUSIONS: Endoscopic endonasal DCR with stent is a safe and minimally invasive procedure and is an effective treatment for patients who have failed primary endoscopic DCR without stent and also in cases of mucocele and pyocele of the sac. }, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Sharma_2021, title = {COVID-19 and anticoagulant based therapeutics: approach with great promise}, author = {Varun Kumar Sharma and Lomas Kumar Tomar and Charu Tyagi and Jayanad Manjhi and Yugandhar P. Reddy and Santosh Kumar Tiwari}, url = {https://pdf.sciencedirectassets.com/277405/1-s2.0-S1876034121X00056/1-s2.0-S1876034120306705/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEJ7%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQDRAeWS4w8DsEvBaCWdCCuNM1YicXv4J3wTC1LEosts%2FAIhAKijTjbvtywEIEJAyq2lx%2B%2BuZZCypK2jZGkus7%2F2Jh%2BwKrwFCLf%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQBRoMMDU5MDAzNTQ2ODY1Igx3S2shtPadWqHfXQsqkAXcqnaQVDjdCUdsvEPOzY4szEHZ9Os1n8UfHkx67W%2BYSQ28vC1Tj50c0fxvDhkhNx8ddWLPqt1C%2BcVWpiH4uiN3lnyDIRpg19fREcvxuO%2F1VCn2k%2FKId%2B5zZ9fo9%2Bq3wFt%2FDNqv%2BaQobmqvtZkbS5EsvVNHsCHNjw1HvqjjWzZQ5g%2Bdg%2FdZom1%2BwDe%2B1sxa8m9H7APJQ04MKe5PKtw7qMGn5f57VBsfHBJAs7zDfjxFQC%2BgwEG%2Bl3kv04UTzxdw3%2BgnvOAz5I7teS8BJFYmGOvWaOnsopO1qTdtazOJQT1GUEdHD7p02o0XyyLkvw%2BmUniGPF3ICRgRyUeMyx2phY335gRv4MmUSV6JqpN1%2FeWSz0h75XmyZRAOXl7ErokQPbvrFWem7gQfIGdRqRQ0BKj0twbZNZsWtllff9EuVgMjAXePNkYOM004G6hDPK6%2BNDBq2Dn0JUo%2BG1JmDsOKqzHO6Myu0ulHpiw51qfxKndLQan0IOqUHS%2FuX2ZcatXnv5j9835PxoJp5OiZACXFsma1sisGKBmtjzURvY7F2ik0rvwWGdk5O2eS9mVap7LQEezUm388xg1deZqIElr7FV6Les7tkekow38O5VeaPiElVH%2FF2YS7G%2BmDFakx8vWH1GmB2fWbtbRJMTs9pf0h2jLA9iZ6C%2FxaQoX9t0BUu0PWeWm09E6YzMo8dh47nvZL70oB7VAOXVc%2FN2F9RRap8xEnCkJ1Xso2z9X1p4%2BQvEoi2SDWNQ%2F91jKxDfRf3i62TJ2OfD1OFx1zjaFpAe71FyL%2F9vY1NNRJ%2FsF%2FFhKsLG7kDm9go%2BRow%2BYt1H3PSXkQwg9oI7k%2B%2FxyJYgd4R3y9HsQLi2YIq22LKsfyC%2BvbDVqh2jCbg8OpBjqwAYooU%2B1d%2F%2FmgCu90yJMNVnlEUzrQcQORrCAO8RdhUBI5%2BvI8ac2aMlfCxJf5j5SBQb8GVj1cuEi5q5YugmPU3yDul3wd6wHmF%2F7qbH6BOFbVnE7hWVUoQ59dRZNoMfQmsis25%2Fa%2BxnYh%2BKax5I7QDuEbr9cbLT0WtZ%2FgWM80GDHRV8Qhg%2F2X1EG58I1AvJFS88cBfj%2Bg6o1ofoEiSlzjwtodnWuxH6E0J8gTt8po4gZE&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231019T063617Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYT464ESVU%2F20231019%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=26a752bdcff19ceb155bb926d691b3fdc40740e4fe38f6b63a11379fd74acaac&hash=c871e24d084704d2c1780633b4aa6abc480224f0a003e7953687ccf6ddab6f92&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S1876034120306705&tid=spdf-ce493a3c-fcf1-423e-818f-18a542be280a&sid=5010876e6fc130474c4b47e5adff7fcf6bb4gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d57515b5054555650&rr=818701809fef2e9f&cc=in}, doi = {10.1016/j.jiph.2020.09.014}, issn = {1876-0341}, year = {2021}, date = {2021-05-01}, urldate = {2021-05-01}, journal = {Journal of Infection and Public Health}, volume = {14}, issue = {5}, pages = {681-682}, publisher = {Elsevier BV}, key = {pmid33248908}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2021b, title = {Role of neutrophil/lymphocyte ratio as a prognostic marker of cerebrovascular accident}, author = {Syed Arshad Hussain and Idrees Akhtar Afroze and T. S. Shamshuddeen}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_May_2021_6510266714_9307901.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2021}, date = {2021-05-01}, urldate = {2021-05-01}, journal = {International Journal of Scientific Research}, volume = {10}, issue = {5}, pages = {76-77}, abstract = {NA}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Sirajuddin_2021, title = {The attenuation of cardiovascular responses to tracheal extubation with lignocaine as compared with propofol}, author = {Mohammed Sirajuddin and Naseeba Fatima and Zara Batool and Mohd. Azam and Bushra Tarannum and Aisha Arif Ebrahim}, url = {https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_3411_v2.pdf}, doi = {10.21276/ijcmr.2021.8.4.7}, issn = {2393-915X}, year = {2021}, date = {2021-04-30}, urldate = {2021-04-30}, journal = {International Journal of Contemporary Medical Research}, volume = {8}, issue = {4}, pages = {D6-D9}, abstract = {Introduction: With the introduction of endotracheal anaesthesia by Ivan W Magill, the father of endotracheal anaesthesia (1914-1920) and the advent of balanced anaesthesia by John Lundy 1925, the use of controlled ventilation technique has almost become universal. The study was conducted to know the Attenuation of Cardiovascular responses to Tracheal Extubation with Lignocaine as compared with Propofol at deccan college of medical sciences, Kanchanbagh, Hyderabad. Material and Methods: 75 patients belonging to ASA-1 and 2 of both the sexes (each group 25 patients n =25) undergoing surgery under general anaesthesia were randomly selected for the study. Patients of either sex with ASA grade 1 and 2 and the patients age ranged between 25 to 50 years were taken into study. Patients with history of respiratory problems, angina, palpitation, baseline systolic BP<100, coronary artery disease were excluded. Results: The pulse rate in test group showed a slight increase at 20 minutes followed by a insignificant decrease during the subsequent one hour period. But in control group the pulse rate decreased to about 12% below the preoperative level showing a statistically very highly significant change. Systolic blood pressure in test group fell by a maximum of 7.29% when compared to control group where it fell to a maximum of 19.18% and diastolic blood pressure in test group fell by a maximum of 3.69% as compared to control group where the decrease was 12.28%. Thus the difference was statistically very highly significant. Conclusion: It establishes the usefulness of an IV bolus dose of propofol 0.5 mg/Kg to attenuate the haemodynamic response to extubation. Propofol 0.5 mg / Kg is too superior to lignocaine 1 mg / Kg in prophylaxis of extubation response. When propofol and lignocaine were used in the study group by attenuation of cardiovascular responses to tracheal extubation no adverse side effects were encountered.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Chetan_2021b, title = {The relationship between anogenital distance and benign prostate hyperplasia‐related lower urinary tract symptoms}, author = {V. Rahul Chetan}, url = {https://www.iaimjournal.com/storage/2021/04/iaim_2021_0804_10.pdf}, issn = {2394-0026}, year = {2021}, date = {2021-04-30}, urldate = {2021-04-30}, journal = {International Archives of Integrated Medicine}, volume = {8}, issue = {4}, pages = {75-78}, abstract = {Background: Anogenital distance is often used as biomarker of intra uterine androgen levels. The androgen may influence the benign prostatic hypertrophy and lower urinary tract symptoms subsequently. This was mainly undertaken to study the relation between the anogenital distance and the lower urinary tract symptoms. Material and methods: A comparative study was undertaken among 50 LUTS patients and 50 controls in Urology department of a tertiary care hospital. All the cases were studied for International Prostate Symptom Score (IPSS), Prostate volume, Maximum flow rate (Qmax), Prostate specific antigen (PSA), testosterone levels, height, weight were recorded. Two types anogenital distance was obtained AGDAP (from the centre of the anus to the cephalad insertion of penis) and AGDAS (from the center of the anus to the posterior base of the scrotum) were measured. Results: The maximum flow rate was significantly higher in controls. This study had shown that the AGD was higher in cases than controls. The PSA levels were significantly higher in LUTS patients and also testosterone levels. The BMI adjusted values of AGD (AS) also was significantly lower in LUTS group than the controls. Conclusion: The anogenital distance can be a marker for benign prostatic hyperplasia and this knowledge can be used for prevention. }, keywords = {Urology}, pubstate = {published}, tppubtype = {article} } @article{Ur_Rahman_2021b, title = {Prevalence and risk factors for the development of abdominal aortic calcification among the US population: NHANES study}, author = {Ebad Ur Rahman and Muchi Ditah Chobufo and Farah Fatima and Adee Elhamdani and Arfaat Khan and Ellen A. Thompson and Wilbert Aronow and Mehiar El-Hamdani}, url = {https://amsad.termedia.pl/pdf-132231-71912?filename=Prevalence%20and%20risk.pdf}, doi = {10.5114/amsad.2021.105527}, issn = {2451-0629}, year = {2021}, date = {2021-04-20}, urldate = {2021-04-20}, journal = {Archives of Medical Science – Atherosclerotic Diseases}, volume = {6}, issue = {1}, pages = {95-101}, publisher = {Termedia Sp. z.o.o.}, abstract = {Introduction: Abdominal aortic calcification (AAC) is an important marker of subclinical cardiovascular disease and its prognosis. Advanced age, hypertension, smoking, dyslipidemia, diabetes mellitus, and higher truncal fat are known markers of AAC in studies conducted around the world. However, literature for these risk factors and their co-occurrence is limited in the US. Material and methods: We used data from dual energy X-ray absorptiometry (Hologic, v4.0) to detect the occurrence of AAC in a sample population (n = 3140) of the NHANES survey using a computer-assisted interviewing system to assess the risk factors for AAC. Results: We found the national prevalence of AAC in the US to be 28.8%. After adjusting for confounders, persons with hypertension: OR = 1.66 (95% CI: 1.30–2.13) and smokers: OR = 1.63 (95% CI: 1.24–2.14) were more likely to have AAC compared to their respective counterparts. Increasing age was positively associated with AAC: OR = 1.06 (95% CI: 1.04–1.08). There was a statistically significant negative association between body mass index (BMI) and AAC, more so in smokers than in non-smokers: OR = 0.97 (95% CI: 0.94–0.97). We did not observe any statistically significant association between diabetes and AAC. Conclusions: Advanced age, smoking, and hypertension was associated with increased occurrence of AAC. Paradoxically, increasing BMI was inversely associated with AAC and there was no statistically significant association between total body and trunk fat percentages and AAC. To the best of our knowledge, this is the first study to establish the nationwide prevalence and associated factors in the US.}, key = {pmid34027218}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Garcia_2021, title = {Identification of potential antiviral compounds against SARS-CoV-2 structural and non structural protein targets: a pharmacoinformatics study of the CAS COVID-19 dataset}, author = {Rolando García and Anas Hussain and Prasad Koduru and Murat Atis and Kathleen Wilson and Jason Y. Park and Inimary Toby and Kimberly Diwa and Lavang Vu and Samuel Ho and Fajar Adnan and Ashley Nguyen and Andrew Cox and Timothy Kirtek and Patricia García and Yanhui Li and Heather Jones and Guanglu Shi and Allen Green and David Rosenbaum}, url = {https://pdf.sciencedirectassets.com/271150/1-s2.0-S0010482520X00175/1-s2.0-S001048252100158X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEKH%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQDDyTGHffzPCz4UxZGGmD3AtYiElLYWmwtA2Q9m%2FVwXGwIgTC98c4FXFtfso5RgKRLqZbmy4siF6Ypq%2FdIrGJRffN0qvAUIuf%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FARAFGgwwNTkwMDM1NDY4NjUiDIM2lL66kE%2BwBgMG8iqQBUw8tWuhgNo%2Bw4igkZwhs5ZQ8ht%2FeZU8AEacDXu9MdlMMFT8TNZZb7a2E7OvClfKrAmsHuzDSlK71NFV4zrcUdPqLWjL5AyCrR0rpVzUMJxqUc%2Bq%2BmmnrOiOppY5UberAehof7eiO8qT6%2Bs%2BqLLTVXd0kG4zHnWli5EX98a%2FK8azuB%2BmSrOc9%2BpPkmqg5BE03lCDoJwq1BThHA2sxHHiyzOILfHlezktUf2h2%2FDlLMR%2BN5BPIs7Ys66k2kdIjOqefy6eBsuAdXUGTGJ2WHmbJreKeSKwu7DTpfD7lRUoXsK2UN%2FjVlM8qAS1o4x5IQGtd0C3s632IVykzt3uKRLNmZHLTpcHaG4XvReYaQIuroHaS3s%2B63aWwMLb%2FAejs%2B4KSAUZO5il0F%2BaOIN1VLhsP%2FtmFMqSH5WmqN2gsBPP13BXBdwJxCIiEPheSIo66itzRAwCvxYC0Puxe14jHH99IyxPk7HxtRbnJh%2FWnkesWVy3pXtZ3FsjXcigWSRT8kIfYCdobmppLt%2BKvgFhiXvRurVUzP4kbivuJD%2FLRSLQdPxOydpBgnAOgTzTT1waR9qYSKaowkg0R%2B9h%2FpJXaU3IyxQCJTmEpyLpK%2BhS9OtLXFqzhAHb76XZlRaM82BB%2F1HhmeXsXqdI5iJoMMnaQxOWxeVjBog9aizX3fnpW1nf7bpqFr7Y3D4N9Qq2ET9c%2F07iywjtItcCdR8ZCU3egkYPWY8yJAzcyhi5BDj024xmlNSC7LFMHua6fGpkdftggDFL6mgtkYkapZPTRhXYlPTBAE%2FKeUM4ZaFkvC1mg%2BTQ5VeUKVc7k8xbCqaSi9TTog5lzXn6L0PjlL8nt3AxK9RfBhwRJzGU0hLz2lF%2Bg761fGVCMIPNw6kGOrEBheOpT2b7lUQihgXbPKFsofQBTnTeZobkAdvfXGQN6XK2i9vdyrxV1QWZCqms4EGHe0vK1qIIbTqnbPuOT4wLjJo4TdWwOOQkjaKp1XHc0uuKl1AWp8Tge31Jl%2B7Q1794NCLoqQWmZG5oa0BRznHh6jPTPk7eR7KWoNWxxALol2qJzXTPko1VlNZJevALPYya%2F4QFOyPxk%2FK8Mt8%2FecQhiuQG1rYJwS1SKafXqQuIUSms&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231019T092504Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY7Q66TPFQ%2F20231019%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=fb19ea929f036776bd3c9f7ed2eb8ea69f87bfe64d097513caf65813f1135b99&hash=5bc780cf8c2c8de6d8dc22cc9d9c820e6fec0ec466c1ad2e3786f67cff1fb232&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S001048252100158X&tid=spdf-bd107f0a-ce80-47e9-a4bb-58d065d64566&sid=5010876e6fc130474c4b47e5adff7fcf6bb4gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d57515b50025c0c04&rr=8187f8bd38f22e87&cc=in}, doi = {10.1016/j.compbiomed.2021.104364}, issn = {0010-4825}, year = {2021}, date = {2021-04-19}, urldate = {2021-06-01}, journal = {Computers in Biology and Medicine}, volume = {133}, pages = {104364}, publisher = {Elsevier BV}, abstract = {SARS-CoV-2 is a newly discovered virus which causes COVID-19 (coronavirus disease of 2019), initially documented as a human pathogen in 2019 in the city of Wuhan China, has now quickly spread across the globe with an urgency to develop effective treatments for the virus and emerging variants. Therefore, to identify potential therapeutics, an antiviral catalogue of compounds from the CAS registry, a division of the American Chemical Society was evaluated using a pharmacoinformatics approach. A total of 49,431 compounds were initially recovered. After a biological and chemical curation, only 23,575 remained. A machine learning approach was then used to identify potential compounds as inhibitors of SARS-CoV-2 based on a training dataset of molecular descriptors and fingerprints of known reported compounds to have favorable interactions with SARS-CoV-2. This approach identified 178 compounds, however, a molecular docking analysis revealed only 39 compounds with strong binding to active sites. Downstream molecular analysis of four of these compounds revealed various non-covalent interactions along with simultaneous modulation between ligand and protein active site pockets. The pharmacological profiles of these compounds showed potential drug-likeness properties. Our work provides a list of candidate anti-viral compounds that may be used as a guide for further investigation and therapeutic development against SARS-CoV-2.}, key = {pmid33895457}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ur_Rahman_2021, title = {Association of atrial fibrillation with outcomes in patients hospitalized with inflammatory bowel disease: an analysis of the National Inpatient Sample}, author = {Ebad Ur Rahman and Vijay Gayam and Pavani Garlapati and Neelkumar Patel and Farah Fatima and Adee El-Hamdani and Arfaat Khan and Paul I. Okhumale and Wilbert Aronow and Mehiar El-Hamdani}, url = {https://amsad.termedia.pl/pdf-132837-71907?filename=Association%20of%20atrial.pdf}, doi = {10.5114/amsad.2021.105256}, issn = {2451-0629}, year = {2021}, date = {2021-04-12}, urldate = {2021-04-12}, journal = {Archives of Medical Science – Atherosclerotic Diseases}, volume = {6}, issue = {1}, pages = {40-47}, publisher = {Termedia Sp. z.o.o.}, abstract = {Introduction: We aimed to determine in-hospital outcomes, length of hospital stay (LOS) and resource utilization in a contemporary cohort of patients with inflammatory bowel disease (IBD) and atrial fibrillation (AFIB). Material and methods: The National Inpatient Sample database October 2015 to December 2017 was utilized for data analysis using the International Classification of Diseases, Tenth Revision codes to identify the patients with the principal diagnosis of IBD. Results: Of 714,863 IBD patients, 64,599 had a diagnosis of both IBD and AFIB. We found that IBD patients with AFIB had a greater incidence of in-hospital mortality (OR = 1.3; 95% CI: 1.1–1.4), sepsis (OR = 1.2; 95% CI: 1.1–1.3), mechanical ventilation (OR = 1.2; 95% CI: 1.1–1.5), shock requiring vasopressor (OR = 1.4; 95% CI: 1.1–1.9), lower gastrointestinal bleeding (LGIB) (OR = 1.09, 95% CI: 1.04–1.1), and hemorrhage requiring blood transfusion (OR = 1.2, 95% CI: 1.17–1.37). Mean LOS ± SD, mean total charges and total costs were higher in patients with IBD and AFIB. Conclusions: In this study, IBD with AFIB was associated with increased in-hospital mortality and morbidity, mean LOS and resource utilization.}, key = {pmid34027213}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Musa_2021, title = {Popliteal vein aneurysm in a teenager with knee swelling}, author = {Juna Musa and Masum Rahman and Kristi Saliaj and Abu Bakar Siddik and Ronny Khadra and Ali Guy and Qemajl Aliu and Kulsum Madani and Ina Kola and Elton Ceka}, url = {https://pdf.sciencedirectassets.com/313380/1-s2.0-S1930043321X00040/1-s2.0-S193004332100159X/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEKD%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJIMEYCIQDWDhXJ%2BZY8U8%2Fv8j4PUBgRdytjwzgVCWlM8a%2BZXdEM9gIhAP2%2BD1zDM599kVs%2Fjd08IBcSPPP1rk94pTeayqBD%2FdZ3KrsFCLn%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEQBRoMMDU5MDAzNTQ2ODY1IgwrkNeakW0g1gEDRP0qjwU%2BJVmd4qUAG2PAQOhp3UTWn3i%2BdwubjH3YtylqyCPBCu9yd0WY3GQ73XtIDEU1j1hzppjFic2wdD7JxdHDTnzoecrkWPeEIanse85a2W6zDC%2BA6kBCmvfA2ASmxJqKLDXLm5JPDnDTtQruX56kWoSWx%2FZg2vOW98DZxOZMXh4Z3Wh%2F%2BbRfe2kPcXza3H6qiBU5pG%2B%2Bvx20AA183sjGlMbKKgXPDAYQay%2FmziE47t8IdD7VJwkeN6Ae6A%2BoP0gkshj0rTTjQsA%2Fb5BpCt8lRV0hZUBoIPWkPlWrKN9y3j4no44KkQsjR8B%2B%2BeSVIclRl2F14uf5tlfcttpEFHI8BwSa8%2BF9Ah7%2B%2BUiXSAexgE5jCJqfRRFtT7MZgsHYJRutpS6CyI4elGqADVzAN7tkueUL%2FGs757o15smjfhD081%2Fgm1QAUuqxTL8mB3dFJoCq2WmsF02smsquA2MQzIFPWo%2Fg4Qq94JLE66Hd%2FGP2qUy7LcJarAuqZfwgt9zAjFBY2Gr9MfPEhAF99tv3OjtRMLKZTWQ7u%2BYS4I3yEYvQs2fi%2FESDLFDEC6NUIBxkxgvFyGq4fiFYjv0AQkOrDFFANCKu%2FXuerasQS2HbuYNK5NhjlcWCRY5B9XWNmgScEr0AU2DaDbR9aU%2BPuK37B1WTQd9AmmpoBEUs48QTEq9UxcKWh8IEBv6YLHIWHHmJnmUgIItQPEwDD3vJ%2Bm%2F2AchEov99%2B9CumMce6XYiBLEtuSe7d1LrcpQ%2Bs2iEyvX5Jz01FB68hIHsnxbOBpIMls3OIma37KJEbPF2iJOB0nL1Jz0eZqUFDako8AniKK2kKBMNr564nkmW8a%2F3O4veTm0noC66wIhXSjcQe4TfNSNA9%2FuFMODDw6kGOrABIcRonfeGEKUsbFU%2BzcJoGzYCx9qVqJX4VvqVyIzS75sIA5e1iRkyjRiDS%2F6II%2BxGZbjg6B2WMvAh1Zah6eZ2GiurWyNnK%2BzPdsgJ7PaiZ8tO56F40jJrnTF70N9sfosAX%2BSnC2vQvfNkIWPC9LDJMkF5ifGkQO7IcBA5WMRg7vGtBNCgT%2BKHKbxGBYU3d0mqNg4w2i5tmrjZi8d8AtC4C3hcDn82ji3oc%2FxndHfIxig%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231019T090915Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYXOKENCUZ%2F20231019%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=9aab4142122f16b0963713000dd44943c05d3d025660a54e6a9e2cfc34f23051&hash=6762f5190471c30a57f65baea0ebf8c25b7aa01010497ae0f0c6d62683b4c7eb&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S193004332100159X&tid=spdf-605d3cf2-e7fa-48ef-ae96-d90960f8e3e2&sid=5010876e6fc130474c4b47e5adff7fcf6bb4gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d57515b5001555606&rr=8187e18f5f892e84&cc=in}, doi = {10.1016/j.radcr.2021.03.022}, issn = {1930-0433}, year = {2021}, date = {2021-04-10}, urldate = {2021-06-01}, journal = {Radiology Case Reports}, volume = {16}, issue = {6}, pages = {1410-1419}, publisher = {Elsevier BV}, abstract = {Primitive vein popliteal aneurysms are rare and potentially fatal vascular disorders. The most dangerous complications of popliteal vein aneurysms are thromboembolic events, mainly pulmonary embolisms, a life-threatening event that requires a timely diagnosis and prompt management. As a treatable cause of recurrent pulmonary embolisms, their actual incidence is believed to be underestimated. Herein, we present a case report of a popliteal vein aneurysm in a previously healthy16-year old male, presenting with a swelling behind his left knee that causes minimal discomfort while walking. When feasible, early surgical repair of both symptomatic and asymptomatic popliteal venous aneurysms is advised, since they are associated with an ill-defined possibility of pulmonary embolism and mortality, if left untreated.}, key = {pmid33912255}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2021b, title = {A study on etiology and clinical profile of respiratory distress among neonates received in NICU at a tertiary care centre in Hyderabad}, author = {Mohammad Kamil Ahmed and C. V. S. Lakshmi and Uppin Narayan Reddy}, url = {https://www.ijmrhs.com/medical-research/a-study-on-etiology-and-clinical-pr-ofile-of-respiratory-distress-among-neonates-received-in-nicu-at-a-tertiary-care-cen.pdf}, issn = {2319-5886}, year = {2021}, date = {2021-04-01}, urldate = {2021-04-01}, journal = {International Journal of Medical Research & Health Sciences}, volume = {10}, issue = {4}, pages = {37-45}, abstract = {Background: Respiratory distress is the most frequent cause of admission in neonatal intensive care in both term and preterm infants. The clinical presentation of respiratory distress can vary from mild to severe respiratory distress requiring mechanical ventilation, and also depends on the respiratory support received before referral to a higher center. The etiology for respiratory distress depends on fetal, maternal, and environmental risk factors, and also on gestational age and birth weight. Objectives: This study was performed to assess and analyze the risk factors, etiology, clinical profile, morbidity, and mortality of neonates admitted with respiratory distress in NICU. Methods: This was a prospective study was done on 292 neonates admitted to Neonatal Intensive Care Unit (NICU) with respiratory distress. General information, socioeconomic status, detailed perinatal history, and clinical examination were documented. Results: 292 neonates admitted with respiratory distress were included in the study. Around 151 (51.7%) babies were born prematurely. The mode of delivery was LSCS in 254 (87.16%) neonates. The most important risk factors were delivery by Cesarian section and maternal infection (49%). Transient tachypnea of the newborn (45.2%), Congenital pneumonia (22.2%), and Late-onset sepsis (10.9%) were the most common causes of respiratory distress. 32.1% of these infants required respiratory support in the form of invasive and non-invasive ventilation. Only 3 infants (1.03%) of infants expired during the study period, due to severe RDS and late referral to the hospital. Conclusion: The most important risk factors for respiratory distress are delivery by Cesarian section and maternal infection. Early referral and early respiratory support help in better outcomes.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Anjum_2021, title = {Chromobacterium violaceum: a report of two cases of septicaemia and wound infection}, author = {Iqra Anjum and Maimoona Mustafa and Mohammed Khaleel}, url = {https://www.ijmmtd.org/journal-article-file/13471}, doi = {10.18231/j.ijmmtd.2021.013}, issn = {2581-4753}, year = {2021}, date = {2021-03-26}, urldate = {2021-03-26}, journal = {IP International Journal of Medical Microbiology and Tropical Diseases }, volume = {7}, issue = {1}, pages = {57-61}, abstract = {Background: Chromobacterium violaceum is a rare cause of human infection, which may become life threatening to its’ ability to rapidly disseminate. Cases are few and far between but with the climate change can increase in number. Here we discuss two (2) cases of infection with C. violaceum isolated at our hospital in South India. Materials and Methods: Samples collected with all aseptic precautions were subjected for aerobic culture and the isolates subjected to various biochemical tests for identification. Result: Infection by C. violaceum was confirmed in both the cases and appropriate antimicrobial administered. Conclusion: Timely treatment with appropriate antimicrobial agents can reduce morbidity and prevent mortality by halting the progression of a local infection to systemic disease. }, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Sadiq_2021, title = {Antidiabetic effect of nigella sativa compared with metformin on blood glucose levels in streptozotocin induced diabetic albino wistar rats}, author = {Neeraj Sadiq and Ghulam Subhani and Syeda Ayesha Fatima and Mohammed Nadeem and Shaima Zafer and Mohammed Mohsin}, url = {https://www.ijbcp.com/index.php/ijbcp/article/view/4579/3149}, doi = {10.18203/2319-2003.ijbcp20211016 }, issn = {2279-0780}, year = {2021}, date = {2021-03-22}, urldate = {2021-03-22}, journal = {International Journal of Basic & Clinical Pharmacology}, volume = {10}, issue = {4}, pages = {361-367}, abstract = {Background: Antidiabetic drugs are many but all of them have adverse effects ranging from simple side effects to serious side effects like hypoglycemic coma. We need alternative drugs which will not only lower blood sugar level but have fewer side effects. One such daily use ingredient in our food is Nigella sativa (kalonji) which has many properties. Methods: This was an objective study in an experimental animal. We divided albino wistar rats into six groups each group with six rats. Diabetes was induced using drug streptozotocin. Three doses of Nigella sativa 0.5 ml, 1 ml, 1.5 ml orally per rat were used. Metformin (100 mg/kg body weight) was used as standard drug. Blood sugar was estimated using glucometer on day 0 (starting day of treatment), day 5, day 10, day 20, day 40. The effect of Nigella sativa was compared with metformin group using the Anova test. Statistical analysis was done using SPSS software version 20. Results: Nigella sativa (NS) produced significant hypoglycemic effect. NS in the dose of 0.5 ml, 1 ml and 1.5 ml produced significant reduction in blood glucose in comparison to day 0. Metformin also (100 mg/kg body weight) produced significant reduction in blood glucose on day 20 and day 40. Comparison of hypoglycemic effect of Nigella sativa is not significantly different on day 10 (1 ml) and day 20 (1.5 ml) in comparison to Metformin (100 mg/kg body weight). Histopathological examination showed that there was partial regeneration of beta islet cells of pancreas by 1.5 ml of Nigella sativa which were damaged due to streptozotocin treatment. Conclusions: Alternative method of treatment for diabetes is very much needed and the study shows the use of the spice (Nigella sativa) daily can lower the blood sugar levels and can serve as an alternative treatment of diabetes mellitus.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Shiza_2021, title = {Exceptionally large kidneys in autosomal dominant polycystic disease in India}, author = {Saher T. Shiza and Jyothsna Guttikonda }, url = {https://www.cureus.com/articles/53774-exceptionally-large-kidneys-in-autosomal-dominant-polycystic-disease-in-india#!/}, doi = {10.7759/cureus.13905}, issn = {2168-8184}, year = {2021}, date = {2021-03-15}, urldate = {2021-03-01}, journal = {Cureus}, volume = {13}, issue = {3}, pages = {e13905}, publisher = {Cureus, Inc.}, abstract = {We report a case of exceptionally large kidneys in autosomal dominant polycystic kidney disease (ADPKD) in India. A 43-year-old male with a family history of ADPKD presented with abdominal pain, intermittent fever, and a sense of bilateral fullness in both flanks. On examination, he had bilaterally enlarged kidneys extending towards iliac fossae. The serum metabolic panel revealed elevated serum creatinine and blood urea nitrogen. Ultrasound abdomen and pelvis showed enlarged kidneys with parenchyma replaced by multiple varying-sized cysts and few cysts in both the kidneys leading to hemorrhagic transformation. CT abdomen showed bulky bilateral kidneys with multiple non-communicating cysts, with few cysts showing the hemorrhagic and calcific transformation. The right kidney measured 30.3 x 15 cm, weighing 9 lb, was resected. The left kidney measured 37.0 x 14.0 cm and was resected three months later. The specimen weighed 19.8 lb. Histopathological examination showed a gross specimen with a bossellated surface composed of sub-capsular multiple cysts of varying sizes. Both the enlarged kidneys were resected due to cyst hemorrhage and infection. The patient is currently on hemodialysis until he receives a renal graft.}, key = {pmid33880261}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Singh_2021, title = {Association of guillain-barre syndrome with COVID-19: a case report and literature review}, author = {Romil Singh and Saher T. Shiza and Rabeea Saadat and Manal Dawe and Usama Rehman}, url = {https://www.cureus.com/articles/52954-association-of-guillain-barre-syndrome-with-covid-19-a-case-report-and-literature-review#!/}, doi = {10.7759/cureus.13828}, issn = {2168-8184}, year = {2021}, date = {2021-03-11}, urldate = {2021-03-01}, journal = {Cureus}, volume = {13}, issue = {3}, pages = {e13828}, publisher = {Cureus, Inc.}, abstract = {There is growing evidence of neurological involvement in patients with coronavirus disease 19 (COVID-19), suggesting that Guillain-Barre syndrome (GBS) can also occur with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a neurological complication. Herein, we describe a unique case of a 45-year-old male who manifested with sudden onset progressive symmetric ascending paralysis leading to quadriplegia one week after developing fever, cough, and dyspnea. On examination, he had areflexia in lower limbs and hyporeflexia in upper limbs. Hypoesthesia to fine touch and vibration distal to calf was noted. His reverse transcriptase-polymerase chain reaction (RT-PCR) was positive for COVID-19, and his cerebrospinal fluid (CSF) analysis revealed albumin-cytologic dissociation. The diagnosis of GBS was made based on clinical presentation and neurophysiological studies due to COVID-19. He was commenced on intravenous immunoglobulin, and improvement in his condition was observed. He was discharged to a rehabilitation center for regular physical therapy.}, key = {pmid33854850}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Bengaluri_2021, title = {A comparative study between laprade and larson‘s technique for posterolateral corner [PLC] injury of knee}, author = {Ramesh Bengaluri and C. Rahul Reddy and B. Venkatesh and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2021/vol7issue2/PartC/7-1-145-824.pdf}, doi = {10.22271/ortho.2021.v7.i2c.2628}, issn = {2395-1958}, year = {2021}, date = {2021-03-11}, urldate = {2021-03-11}, journal = {International Journal of Orthopaedics Sciences }, volume = {7}, issue = {2}, pages = {174-180}, abstract = {In the last few decades, injuries to the knee joint are common because of knee pivoting sports. The mechanism of injury to the PLC is due to direct varus stress, hyperextension, or twisting of the knee. These injuries are commonly associated with cruciate ligament tears, but PLC injury are usually overlooked or misdiagnosed. If Left untreated, it can cause chronic pain and residual instability. PLC reconstruction is normally advocated for grade 2 or 3 lesions, as it is superior to conservative treatment. This study is to compare larson’s and laparde techinque. In Larson’s technique there is reconstruction of the fibular collateral ligament and popliteo fibular ligament. In LaPrade technique popliteus graft is reinforced to the PLC. This is a prospective study conducted in 40 patients between April 2016 to January 2018 in Deccan Medical College and Hospitals, to compare the clinical outcome of Laprade and Larson’s techniques in terms of best post-operative stability and function of an isolated PLC injury. Inclusion criteria:age ranging from 18 to 40 years, Posterio lateral corner injury, No previous surgery or damage in the affected knee or the contralateral knee. Exclusion criteria: Patients with medial collateral ligament injury, cruciate ligament injury, generalized ligamentous laxity and arthritis knee. Methods and analysis of results: it is randomized study between Larson’s technique and Laprade’s technique. Postoperative evaluation: is by Lysholm score, IKDC scores and Postoperative complications. In conclusion it revealed that both methods are significant, and equally good at postoperative outcomes.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @inbook{Manorenj_2021d, title = {Clinical aspects of Moyamoya disease. In: Moyamoya disease- a disease to count on in your daily practice}, author = {Sandhya Manorenj and Reshma Sultana Shaik}, url = {https://www.intechopen.com/chapters/75446}, doi = {10.5772/intechopen.92950}, isbn = {978-1-83968-387-9}, year = {2021}, date = {2021-02-26}, urldate = {2021-02-26}, publisher = {IntechOpen}, chapter = {3}, abstract = {Moyamoya disease is a chronic progressive, non-atherosclerotic, occlusive intracranial vasculopathy involving major cerebral arteries around the circle of Willis. MMD occurs frequently in East Asian populations but the disease can affect the American and European ethnicities as well. Knowledge of clinical aspects of Moyamoya disease (MMD) is important in view of distinctive clinical presentation observed in children and adults. MMD has bimodal age of distribution, with peaks in the first and last decades of life. Childhood MMD is characterised by Ischemic manifestation (Transient ischemic attack, Cerebral Infarction), whereas adult MMD presents with hemorrhagic manifestations (Intracerebral haemorrhage, Intraventricular bleed). Refractory headache, seizure and ophthalmological abnormalities are other clinical presentations of MMD. A high index of clinical suspicion and an eye to recognise the common as well as unusual manifestations of the disease and inciting events may prevent delay in the diagnosis. A thorough knowledge about the varied clinical presentation would aid clinician for early diagnosis and management of this rare entity. The present article provides extensive review on the clinical aspects of MMD amongst adults and paediatric population, on the basis of previous articles and research studies.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {inbook} } @article{Ahmetgjekaj_2021, title = {A case report of Joubert syndrome with renal involvement and seizures in a neonate}, author = {Ilir Ahmetgjekaj and Masum Rahman and Fjolla Hyseni and Ali Guy and Kulsum Madani and Kristi Saliaj and Angela Guy and Valon Vokshi and Ina Kola and Juna Musa}, url = {https://pdf.sciencedirectassets.com/313380/1-s2.0-S1930043321X00039/1-s2.0-S1930043321000947/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEJ7%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIEuIlcqvAQdrC7YEGc1lAiuYVFOWOznW0LMIf6WX5pEdAiAWDTDnoSJOb96%2FjTWZeSQ8y%2BcDfIrTB804JZKmjJuh0Sq8BQi3%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F8BEAUaDDA1OTAwMzU0Njg2NSIMZcqKJ3a49kAvx7LtKpAFHIB6B41QLHkjUDFclB%2FtneNI3txdjYoKpFt1EF71%2F8BGOXRa5X3HuzPv4icclAR5Q2vt4lH9YZTPt3b6%2FWiBY8cNNH1AJOXLM1fQe2QssrPR2dxjpj5gyGf%2BSkDxEvhVlXMl7Fr3oaAQeJMv0WMJFlzkG%2BEWNXaoDM8hEN6QoU8b5%2BgH%2FEYED7JT%2FPVZBr45za0CTcaRgCJSCU5%2BXFwzAHQGnjbOrSdNB9%2Fy1my%2F%2FgwGRW4e3MCr4uJf2L9%2FXvUCo2AptUsxnxkm7GTuuW8vwuDKqAsRQtkjJupAWqm5H%2BW4y4gi%2BjxvN%2BCwWEmSKVR5eWzMyCP%2Ba47k1HqiKBqI%2Feig4X3TTuYLpHcG%2BPd4fnE1BwudKI3K91EdBMTYKNK40FI%2FDRDfg1CKTvP%2FrSMpWtvmm2lhPnTknL18iMjBb2Hl8o2ecsDDXc5m44tnGKaczFTeKKnfUEwDmqOKipk5NDrsHF4yW1PwD5grs%2BwlT3OAFjsBYFTqX3Sw3hy7cSswngPPru9pp90uuUMYRquxmYa5ljz3aogIU5yeQqv2zKNit2JpeKBqh6jB6BfbBVdFYGBiYc%2BhCIeTc6WwXFqbCPTrLGNPrhFi1hk6ThhvTUiq%2Fg2llC4U9zTuvOukzu4M91kI2zlQ31WHOxfB3g0CHOl9JRfqKei%2BrfDZRolwcarpPIwe7MlcjJzfeEp1XznwbatpDD0pNqdaa90vtvUhfHRvRv5wDu4fGh0bPc9ycBIsix4YeARYyUybkdbC4TdhfXW1jwEvsiEkGrSg2AuipPw0pYIh%2FacqyfGA3VRLaaRnbe2i1zjdQWK%2Blb31W%2Ft6E60wTIUbkPwRuxd3WTAmUh9tMlELc5HVtg8H9yRZGmswl4rDqQY6sgEGynt6qcDiS6RQ4VjJOPbSMT%2BLF3prOHTIEPdQVwgUIvCzXJdU1qzcqfdN4l7VM5JEoAK0WonGaZVInQJSlBAt6K160TU5w9E3CbnxMWHjgkaabonsUK0kwjd5BT7c0Z3MBft38M4T%2Bzt0wBw8gwDOfAngU3KohOgsVdvF0rB2BhjV%2FZS6c1GoJmpYxGx2Qazwq4FMSpNrxJ%2BpBt8LwynDrzcUCTVCBXP%2BFJFDjeVUgEEB&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20231019T062941Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTYWSQB2UNX%2F20231019%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=29925e15f98b33e60cf2e49438a9d7919ef80be66cb231a289f37262585279a0&hash=ba881444ad2ae2ef7ddcde048e0b3c8c8030ff0829655d107d6c89e772de3001&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S1930043321000947&tid=spdf-cf304a81-6978-4fb3-89e1-85988c189835&sid=5010876e6fc130474c4b47e5adff7fcf6bb4gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=0f0d57515b5102530a55&rr=8186f7d5589d2e8d&cc=in}, doi = {10.1016/j.radcr.2021.02.031}, issn = {1930-0433}, year = {2021}, date = {2021-02-24}, urldate = {2021-05-01}, journal = {Radiology Case Reports}, volume = {16}, issue = {5}, pages = {1075-1079}, publisher = {Elsevier BV}, abstract = {Joubert Syndrome is a rare autosomal recessive genetic disorder characterized by a distinctive midbrain-hindbrain malformation that gives the appearance of “the molar tooth sign” on axial magnetic resonance imaging (MRI). Mutations in the implicated genes, affect proteins integral to cellular structures like the primary cilium, basal bodies and centromeres, categorizing Joubert syndrome as a ciliopathy. The most common clinical manifestations include moderate to severe hypotonia in early infancy with ataxia developing later in life, abnormal breathing patterns (tachypnea, apnea), atypical eye movements, development delay and intellectual disabilities. Differential diagnosis between different ciliopathies is challenging due to the overlapping clinical features. French neurologist Marie Joubert was the first to describe the clinical findings in 1969 and later the disorder was named after her. In this report, we present the case of a newborn female patient who was admitted to the neonatal intensive care unit 12 hours after birth, presenting with dyspnea, cyanosis, signs of respiratory distress and seizures. During the course of her hospitalization elevated levels of urea and creatinine were detected and after an abdominal ultrasound and CT evaluation bilateral renal hyperplasia and polycystic kidney disease were discovered. An MRI of the head and neck revealed the presence of inferior vermis agenesis, with a medial crack in cerebellum, a partial dysgenesis of corpus callosum, an underlying and thicker cerebral peduncle, as well as the molar tooth sign suggesting a diagnosis of Joubert syndrome. The diagnosis was ultimately confirmed through molecular genetic testing. Through this case report, we hope to draw attention to this rare and elusive group of disorders and emphasize the value of a prompt diagnosis and a proactive and multidisciplinary approach in the management of these patients.}, key = {pmid33717386}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2021b, title = {A study of the cardiovascular risk factor profile in patients with acute coronary syndrome}, author = {Syed Azhar Ali and Mohammed Hidayathulla and Wajhia Sultana and Amina Shareef}, url = {https://www.ijhcr.com/index.php/ijhcr/article/view/876/763}, issn = {2590-3241}, year = {2021}, date = {2021-02-08}, urldate = {2021-02-08}, journal = {International Journal of Health and Clinical Research}, volume = {4}, issue = {3}, pages = {70-73}, abstract = {ntroduction:Acute coronary syndrome (ACS) remains a leading cause of death in the United States. Numerous studies have shown that the risk factors are major if not the most important determinant of long-term outcome in ACS.Aims:This study is taken up to study the cardiovascular risk factor profile in patients with acute coronary syndrome.Materials and methods: 120 patients with acute coronary syndrome, admitted to the ICCU, Department of Cardiology, ,who had been diagnosed with acute coronary syndrome were enrolled for the study.Results: In this study 60% of patients had metabolic syndrome and 40% did not satisfy the criteria for MS. In the MS+ group 59 (82%) are males and 13(18%) are females Mean age of the patients of the study is 51.3 years. Mean age of the patients with and without metabolic syndrome is 52.3 and 48.9 years respectively. 22%, 45.8%, 29%, 20.8% and 16.7% of patients with metabolic syndrome had history of smoking, hypertension, diabetes, obesityand coronary artery disease respectively, of which history of hypertension has statistical significance.Among males, 34 satisfied3 criteria of metabolic syndrome, 17 satisfied 4 criteria and 2 satisfied all 5 criteria of MS. Among females, 3 satisfied 3 criteria of metabolic syndrome, 7 satisfied 4 criteria and 4 satisfied all 5 criteria.Conclusion:The most commonly affected were elderly. Among the risk factors, smoking was the most common risk factor found in the present study.}, keywords = {Cardiology, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Koti_2021, title = {Comparative study of perioperative blood glucose levels in various anaesthetic techniques (general, spinal and epidural) in non-diabetics and diabetics (controlled)}, author = {Vijaya Rekha Koti and Khaja Ali Hassan and Heena Naaz and Aejaz Ul Haq}, url = {https://www.medpulse.in/Anesthsiology/Article/Volume17Issue2/Anes_17_2_2.pdf}, doi = {10.26611/10151722 }, issn = {2579-0900}, year = {2021}, date = {2021-02-07}, urldate = {2021-02-07}, journal = {MedPulse International Journal of Anesthesiology}, volume = {17}, issue = {2}, pages = {44-49}, abstract = {Background: Surgery produces a stress response resulting in various biochemical and hormonal changes. The most widely known metabolic disturbance is elevated blood sugar. Perioperative morbidity and mortality are affected by the inadequate glycaemic control. There are variations in hyperglycaemic response with various anaesthetic agents and techniques. Among the factors affecting genesis of hyperglycaemia Diabetes stands as a strong pillar. Aim: The aim of the study is to evaluate degree of rise of blood sugar levels as a measure of stress during anaesthesia and surgery, under various anaesthetic techniques between non-diabetics and diabetics (controlled). Patients and Methods: The study was conducted at Deccan college of medical sciences, Hyderabad in ninety adult patients (30 to 55 years age), undergoing various elective surgeries of 60 to 90 minutes duration under three aesthetic techniques (General Anaesthesia (GA), Epidural (EA), and spinal Anaesthesia (SA)). 45 of these patients were not diabetic and 45 are controlled diabetics. Rise of blood sugar was compared among three techniques in each group and among similar techniques between both groups. For estimating blood glucose levels, preoperative,4 intraoperative and 2 postoperative venous blood samples were collected. Results: In diabetics and non-diabetics, the blood sugar fluctuation is less with regional techniques and furthermore, less under SA. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2021b, title = {Low dose of intravenous ketamine for prevention of hypotension after subarachnoid block}, author = {Naseeba Fatima and Mohammed Sirajuddin and Sumera Raheem and Aisha Arif Ebrahim and Syeda Rabia Fatima}, url = {https://ijhcr.com/index.php/ijhcr/article/view/860/749}, issn = {2590-3241}, year = {2021}, date = {2021-02-07}, urldate = {2021-02-07}, journal = {International Journal of Health and Clinical Research}, volume = {4}, issue = {3}, pages = {11-17}, abstract = {Objectives and background: The study was conducted to know the efficacy of low dose i.v. ketamine for prevention of hypotension and to compare the hemodynamic changes following subarachnoidblock with intrathecal bupivacaine heavy with or without low dose i.v. ketamine.Materials and Methods: 100 patients belonging to ASA-1 of both the sex (each group 50 patients n =50) undergoing General surgical and orthopaedic operations were randomly selected for the study.Results:The pulse rate in test group showed a slight increase at 20 minutes followed by a insignificant decrease during the subsequent one hour period. But in control group the pulse rate decreased to about 12% below the preoperative level showing a statistically very highly significant change. Systolic blood pressure in test group fell by a maximum of 7.29% when compared to control group where it fell to a maximum of 19.18% and diastolic blood pressure in test group fell by a maximum of3.69% as compared to control group where the decrease was 12.28%. Thus the difference was statistically very highly significant.Conclusion: Low dose i.v. ketamine in doses of 0.3 mg/kg offers superior cardiovascular stability, and low dose i.v. ketamine in combination with midazolam, has good sedative and analgesic properties, reduces the volume of crystalloids required to maintain hemodynamic stability.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2021c, title = {Effect of oral clonidine premedication on spinal anesthesia using levobupivacaine}, author = {Syed Asrar Hussain and U. Jayashree and Mohammed Asraruddin}, url = {https://www.iaimjournal.com/wp-content/uploads/2021/02/iaim_2021_0802_09.pdf}, issn = {2394-0026}, year = {2021}, date = {2021-01-31}, urldate = {2021-01-31}, journal = {International Archives of Integrated Medicine}, volume = {8}, issue = {2}, pages = {63-68}, abstract = {Background: The duration of spinal analgesia can be prolonged by using different techniques including oral clonidine. This study was mainly undertaken in order to study the effect of oral clonidine in levobupivacaine spinal analgesia. Material and methods: A randomized controlled trial was undertaken in 80 patients. About 40 patients received 150 mcg of oral clonidine and 40 patients received placebo. The socio demographic characteristics, hemodynamic parameters, sedation time, time to reach maximum sensory level and time to 2 segment regression were compared between the oral clonidine and placebo groups. Results: There was no statistically significant difference in the hemodynamic parameters between the oral clonidine and placebo groups. The mean sedation score was 1.1 in Oral clonidine group and 1.12 in the placebo group (p=0.728). The mean time to reach maximum sensory level was 9.92 minutes in oral clonidine group and 9.82 minutes in placebo group (p=0.753). The time to two segment regression in oral clonidine group was 108.85 minutes and 109.85 minutes in placebo group (p=0.496). Conclusion: This study had shown no significant difference in the hemodymaic parameters, sedation score, time to maximum sensory level and time to 2 segment regression between the oral clonidine and placebo groups.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Chetan_2021, title = {A comparative evaluation of transurethral electro-vaporization of prostate (TUEVP) versus transurethral resection of prostate (TURP) for benign prostatic hyperplasia (BPH)}, author = {V. Rahul Chetan}, url = {https://www.iaimjournal.com/storage/2021/01/iaim_2021_0801_10.pdf}, issn = {2394-0026}, year = {2021}, date = {2021-01-31}, urldate = {2021-01-31}, journal = {International Archives of Integrated Medicine}, volume = {8}, issue = {1}, pages = {63-69}, abstract = {Background: Benign prostatic hyperplasia (BPH) is considered as an important health problem in the elderly men. TURP is unique surgery for BPH but has prolonged hospital stay and higher complications. TUEVP gives comparable benefits and efficacy with the TURP. Material and methods: A prospective, randomized, comparative study was conducted on patients diagnosed with benign prostatic hyperplasia in the Surgery Department of tertiary care hospital. Eighty patients of symptomatic BPH who were candidates for operative treatment with prostate weighing seventy grams or less would be included TURP and TUEVP was done by using standard operative procedures. Follow up was done after 3 months. Results: This study had shown that, most of the patients were aged above 55 years. The mean operative time was higher in TUEVP group than TURP group. The hospitalization was prolonged in case of TURP in comparison with the TUEVP. The percentage of improvement in IPSS was 82.8% in TUEVP and 85.3% in TURP, QOL was 80.9% in TUEVP and 81.1% in TURP, PVRV was 64% in TUEVP and 68.6% in TURP, maximum flow rate was 124.5% in TUEVP and 150.6% in TURP, Average flow rate was 104.3% in TUEVP and 135.6% in TURP. Conclusion: The benefits and complications of TUEVP were comparable with transurethral resection of prostate.}, keywords = {Urology}, pubstate = {published}, tppubtype = {article} } @article{Chobufo_2021, title = {Prevalence and association of iron deficiency with anemia among patients with heart failure in the USA: NHANES 2017-2018}, author = {Muchi Ditah Chobufo and Ebad Ur Rahman and Vijay Gayam and Joyce Bei Foryoung and Valirie N. Agbor and Farah Fatima and Alix Dufresne and Tonga Nfor and Mehiar El-Hamdani}, url = {https://www.tandfonline.com/doi/epdf/10.1080/20009666.2020.1854927?needAccess=true}, doi = {10.1080/20009666.2020.1854927}, issn = {2000-9666}, year = {2021}, date = {2021-01-26}, urldate = {2021-01-26}, journal = {Journal of Community Hospital Internal Medicine Perspectives}, volume = {11}, issue = {1}, pages = {124-127}, publisher = {Greater Baltimore Medical Center}, abstract = {Background: Heart failure (HF) is a major debilitating disease. HF patients with iron deficiency(ID) have poorer outcomes and treatment significantly improves outcomes. We set out to update the national prevalence of ID in the USA and its association with anemia using data from NHANES 2017–2018. Methods: Diagnosis of HF was self-reported. ID was defined as serum ferritin levels <100 ng/mL or a ferritin level between 100 and 299 ng/mL with transferrin saturation <20%. Anemia was defined as a hemoglobin level of <13 g/dl and <12 g/dl for men and women, respectively. Differences in prevalence of ID across various groups were assessed using Chi-squared test for categorical variables and equality of means for continuous variables with p-values <0.05 considered statistically significant. Results: A total of 187 persons ≥20 years, corresponding to a 5.57million had HF. The prevalence of ID was 48.17% (95% CI 36.84–59.69) and the prevalence of anemia was 12.08%(95% CI 8.16–17.53). Diabetics (61.03%) were more likely to have ID compared to nondiabetics (35.38%), p 0.022. The prevalence of ID was similar in persons with anemia (47.45%) and persons without anemia (48.27%), p-value 0.983. The prevalence of ID has been constant for at least the past 20 years, making ID in HF an underdiagnose and/or undertreated condition among patients with HF and should be addressed. Conclusions: One in every two persons with HF has ID. Also, prevalence of ID was similar in patients with anemia and without anemia. Anemia should not be considered a prerequisite for screening for ID in patients with HF.}, key = {pmid33552434}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Aijaz_2021, title = {Metastatic spread of neuroblastoma to the left atrium mimicking atrial myxoma: a rare occurrence in an adolescent}, author = {Zobia Aijaz and Hafiza M. Durrani and Pulwasha Iftikhar and Raja Ram Khenhrani and Mohammed Faisaluddin }, url = {https://www.cureus.com/articles/44215-metastatic-spread-of-neuroblastoma-to-the-left-atrium-mimicking-atrial-myxoma-a-rare-occurrence-in-an-adolescent#!/}, doi = {10.7759/cureus.12799}, issn = {2168-8184}, year = {2021}, date = {2021-01-20}, urldate = {2021-01-01}, journal = {Cureus}, volume = {13}, issue = {1}, pages = {e12799}, publisher = {Cureus, Inc.}, abstract = {Neuroblastoma is the most common childhood malignancy arising from the sympathetic neuroblast cells. The most common sites of origin are the adrenal glands and paravertebral regions. However, the involvement of the heart is a rare occurrence in adolescents. Here, we report a case of a 12-year-old male child who was misdiagnosed as a case of cardiac myxoma on initial presentation. Following surgical resection and histological examination, neuroblastoma was revealed. This case report highlights the differential diagnosis for the cardiac mass in an adolescent with an unknown primary origin and also the importance of tissue histopathology for the diagnosis and management of neuroblastoma.}, key = {pmid33628668}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Iqbal_2021, title = {The impact of door to diuretic time in acute heart failure on hospital length of stay and in-patient mortality}, author = {Arshad Muhammad Iqbal and Sohaib K. Mohammed and Nida Zubair and Ateeq Mubarik and Adnan Ahmed and Syed Farrukh Jamal and Syed Moin Hassan and Furqan Haq and Salman Muddassir}, url = {https://www.cureus.com/articles/49809-the-impact-of-door-to-diuretic-time-in-acute-heart-failure-on-hospital-length-of-stay-and-in-patient-mortality#!/}, doi = {10.7759/cureus.12742}, issn = {2168-8184}, year = {2021}, date = {2021-01-16}, urldate = {2021-01-01}, journal = {Cureus}, volume = {13}, issue = {1}, pages = {e12742}, publisher = {Cureus, Inc.}, abstract = {Background: Acute heart failure (AHF) can be life-threatening if not treated promptly and can significantly increase the number of annual emergency department (ED) encounters in the United States. Achieving adequate and prompt euvolemic state in AHF patients using intravenous (IV) diuretics is the cornerstone of treatment, which not only reduces in-hospital stay and mortality but also decreases healthcare expenditures. Surprisingly, the door to diuretic (D2D) time in AHF patients has always been a debatable issue among physicians worldwide, and so far, there are no set guidelines. This study examines a large cohort of AHF patients to determine the association between diuretics use within 90 minutes of ED admission and hospital length of stay (LOS) and patient mortality. Methods: Retrospective institutional data of AHF patients receiving IV diuretics following ED admission were extracted from 2016 to 2017. A total of 7,751 patients treated for AHF exacerbation were included, which were further divided into two groups based on the timing of diuretics administration (<90 minutes vs. ≥90 minutes). The primary outcomes were LOS between the two groups and hospital mortality. The standard statistical methodology was used for data analysis. Results: A total of 7,751 AHF cases receiving IV diuretics were identified. Almost 1,432 patients (18.5%) received IV diuretics within 90 minutes of ER admission (group 1) while 6,319 patients (81.5%) patients received IV diuretics after 90 minutes (group 2). Furthermore, among group 1 patients, average LOS was noted to be associated with shorter hospitalization (average of 1.423 days less as compared to group 2 patients (confidence interval (CI) =1.02-1.82; p<0.05). Finally, after controlling for other mortality risk factors, patients in group 2 were 1.435 times more likely to have died compared to patients in group 1 (CI=1.03-1.98; p<0.05). Conclusions: D2D time in AHF patients has always been a crucial judgmental decision. The current study successfully demonstrated the relation between IV diuretics administration within 90 minutes of ED admission, favorable clinical outcomes, and decreased mortality rates. More adequately powered studies are needed to validate the results of our current study further.}, key = {pmid33643721}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2021, title = {Emergence of MIS-C in COVID-19 pandemic}, author = {Mehnaaz Sameera Arifuddin}, url = {https://amphysiol.com/index.php/amp/article/view/v4i3.14465}, doi = {10.23921/amp.2020v4i3.14465}, issn = {2456-8422}, year = {2021}, date = {2021-01-15}, urldate = {2021-01-15}, journal = {Annals of Medical Physiology}, volume = {4}, issue = {3}, pages = {22-23}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Taj_2021, title = {Infective endocarditis leading to intracranial abscess: a case report and literature review}, author = {Shafaq Taj and Muhammad Usman Arshad and Hira Khan and Guneet S. Sidhu and Romil Singh}, url = {https://www.cureus.com/articles/49903-infective-endocarditis-leading-to-intracranial-abscess-a-case-report-and-literature-review#!/}, doi = {10.7759/cureus.12660}, issn = {2168-8184}, year = {2021}, date = {2021-01-12}, urldate = {2021-01-01}, journal = {Cureus}, volume = {13}, issue = {1}, pages = {e12660}, publisher = {Cureus, Inc.}, abstract = {Neurologic complications are a hallmark of infective endocarditis (IE). IE leading to intracranial abscess has an unfavorable prognosis. A 17-year-old boy with a past medical history of aortic valve replacement presented with fever and seizure. On examination, he had tachycardia, systolic murmur, slurred speech, meningeal signs, and right homonymous hemianopia. His laboratory analysis revealed an elevated erythrocyte sedimentation rate and C-reactive protein. The brain's magnetic resonance imaging revealed multiple ring-enhancing lesions in the frontal, occipital lobe, and occipitotemporal lobe, consistent with intracranial abscess. Transthoracic echocardiogram revealed a mobile mass adjacent to aortic value, consistent with possible infective vegetation. He was diagnosed with multiple cerebral septic emboli leading to intracranial abscess due to IE. Blood and cerebrospinal fluid culture revealed methicillin-sensitive Staphylococcus aureus growth. He was started on intravenous nafcillin and gentamycin. His condition improved gradually, and he became afebrile on hospital day four. On his recent follow-up, he was doing well.}, key = {pmid33585144}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Anees_2021b, title = {Acute phase reactants in hemodialysis patients in relation to ejection fraction}, author = {Syyeda Anees and Ruksana Kausar and Shaikh Mahmood and Mohammed Abbas Hyder}, url = {https://www.ijcbr.in/article-details/13118}, doi = {10.18231/j.ijcbr.2020.102}, issn = {2394-6369}, year = {2021}, date = {2021-01-01}, urldate = {2021-01-01}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {7}, issue = {4}, pages = {484-487}, publisher = {IP Innovative Publication Pvt Ltd}, abstract = {Chronic Kidney Disease (CKD) is considered a public health problem because of its high prevalence, morbidity and mortality. 1 Morbidity remains high with more than 20% of patients undergoing hemodialysis dying every year with frequent complications of heart disease, hypertension, anaemia, inflammation and physical function. 2 Coronary artery disease has accounted for 40-50% of deaths among patients who undergo dialysis. Myocardial infarction has approximately accounted for 10-20% of these deaths which occur shortly after initiating dialysis with 29% within 1 year and 52% within 2 years. The risk increases as the kidney function declines. The present study aims to study the serum levels of hs-CRP and ferritin in hemodialysis patients and to correlate with ejection fraction as an indirect association of coronary artery disease and therefore to study the role of inflammatory markers hs-CRP and ferritin in hemodialysis patients and their role as predictive markers in coronary artery disease. The study included 50 hemodialysis patients with CAD and 50 hemodialysis patients without CAD. hs-CRP and ferritin parameters were analysed. hs-CRP and ferritin levels were significantly increased in hemodialysis patients with CAD.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2021, title = {Study of carotid intima-media thickness and its association with coronary artery disease and other risk factors}, author = {Suhail Bin Ahmed and Md. Fawad Ali}, url = {https://www.iaimjournal.com/storage/2021/01/iaim_2021_0801_09.pdf}, issn = {2394-0026}, year = {2021}, date = {2021-01-01}, urldate = {2021-01-01}, journal = {International Archives of Integrated Medicine}, volume = {8}, issue = {1}, pages = {58-62}, abstract = {Background: The investigation of the cardiovascular diseases requires invasive and non-invasive tools in establishing the diagnosis. This study was mainly undertaken to relate the CIMT with the risk factors of coronary artery diseases. Material and methods: A case control study was undertaken in department of General Medicine in a tertiary care hospital in 30 cases and 60 controls. Intima-media thickness was measured by using B mode scanner as the distance between the leading edge of the first echogenic line of the far wall of the carotid artery (lumen-intima interface) and the leading edge of the second echogenic line (media-adventitia interface). Results: The number of risk factors was higher in cases than controls. The cases demonstrated high CIMT than controls. The CIMT increased with increase in number of risk factors. Conclusion: CIMT can be used as non-invasive tool in assessment of coronary artery diseases. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @book{Ahmed_2021c, title = {Forensic Medicine and Toxicology Theory/Practical Skills, Viva}, author = {Khazi Mudabbir Ahmed}, isbn = {978-8195271580}, year = {2021}, date = {2021-01-01}, urldate = {2021-01-01}, booktitle = {Forensic Medicine and Toxicology Theory/Practical Skills, Viva}, publisher = {Paras Medical Books Pvt. Ltd.}, address = {Hyderabad}, edition = {2nd}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {book} } @article{Nazki_2020, title = {Evaluation of serum uric acid levels in type 1 diabetes mellitus patients in association with glycemic control}, author = {Faizan I Asrar Nazki and Sara Mohammed and Syyeda Anees and Mohsin Wazir}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-serum-uric-acid-levels-in-type-1-diabetes-mellitus-patients-in-association-with-the-glycemic-control_December_2020_7466102919_5722389.pdf}, issn = {2277-8179}, year = {2020}, date = {2020-12-31}, urldate = {2020-12-31}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {12}, pages = {65-66}, abstract = {AIMS: To evaluate the serum uric acid levels in Type 1 Diabetes Mellitus in association with the glycemic control. METHODOLOGY: 100 subjects were enrolled (50 controls and 50 type 1 diabetic patients) with age and sex matched. 50 Type 1 diabetic patients were grouped into 3 based on their glycemic status. Venous blood and urine is collected for the estimation of the serum uric acid, serum creatinine, fasting blood glucose and HbA1c. RESULTS: The present study received signicant correlations between SUA and HbA1c with their respective controls with p –value <0.005. The difference of mean values of SUA between Group 2 and Group 3 is not signicant, whereas between Group 1 and Group 3 is statistically signicant (p value <0.01). CONCLUSION: The present study stated that serum uric acid concentration was found to be higher in type 1 DM. The raised UA levels are found to be associated with poor glycemic control in Type 1 diabetes mellitus.}, keywords = {Anesthesiology, Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Mohammed_2020, title = {Evalaution of urinary microalbumin levels in type 1 diabetes mellitus patients in association with the glycemic control}, author = {Sara Mohammed and Faizan I Asrar Nazki and Mohsin Wazir and Syyeda Anees}, url = {https://www.worldwidejournals.com/paripex/recent_issues_pdf/2020/December/evaluation-of-urinary-microalbumin-levels-in-type-1-diabetes-mellitus-patients-in-association-with-the-glycemic-control_December_2020_8160958036_6707308.pdf}, doi = {10.36106/paripex}, issn = {2250-1991}, year = {2020}, date = {2020-12-31}, urldate = {2020-12-31}, journal = {Paripex-Indian Journal of Research}, volume = {9}, issue = {12}, pages = {7-8}, abstract = {Aims: To evaluate the urinary microalbumin levels in Type 1 Diabetes Mellitus in association with the glycemic control. Methodology: 100 subjects were enrolled (50 controls and 50 type 1 diabetic patients) with age and sex matched. 50 Type 1 diabetic patients were grouped into 3 based on their glycemic status.Venous blood and urine is collected for the estimation of the urinary microalbumin, serum creatinine, fasting blood glucose and HbA1c. Results: The present study received significant correlations between MA and HbA1c with their respective controls with p –value < 0.005. The difference of means between Group 2 and Group 3 is statistically significant, and between Group 1 and Group 3 is also statistically significant (p value <0.05). Conclusion: The present study stated that urinary microalbumin was found to be higher in type 1 DM. The raised MA levels are found to be associated with poor glycemic control in Type 1 diabetes. mellitus.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Ali_2020, title = {Plain x-ray and MRI evaluation of painful hip joint}, author = {Syed Althaf Ali and Dwara Manojna Devi}, url = {https://aijournals.com/index.php/ajmrr/article/view/1818/1941}, doi = {10.47009/ajmrr.2020.8.2.5}, issn = {2347-3371}, year = {2020}, date = {2020-12-30}, urldate = {2020-12-30}, journal = {Asian Journal of Medical Radiological Research}, volume = {8}, issue = {2}, pages = {31-35}, abstract = {Background: Hip joint pain is a frequent problem in current practice and can be due to different causes since the investigations are invariably used to diagnose the source of the injury. The primary examination is accompanied by MRI, which is a valuable instrument in hip disease evaluation since it requires a detailed study of articular cartilage, epiphysis, joint fluids, bone marrow and extra-articular soft tissue which may be impaired by hip disease. Subjects and Methods: In a total of 60 individuals who had hip joint pain and subsequently had plain radiographs accompanied by the hip joint MRI was studied in a prospective cross-sectional analysis. The data is interpreted and the results of basic X-rays are compared to the MRI. Results: Of the 70 cases the males (67%) are commonly affected than females (33%). The majority of the patients fall under the age group of 31-40 years (28.33%). In our study, we find the commonest pathology for the hip joint pain is AVN of femoral head 20 cases (28.57%), followed by joint effusion 15 cases (21.42%), Osteoarthritis 13 cases (18.57%), TB hip 10 cases (14.28%), Perthes 4 cases (5.71%), DDH 4 cases (5.71%) and metastatic disease 4 cases (5.71%). Of the twenty AVN cases, only 6 (30%) are found on a plain x-ray whereas all 20 (100%) are detected on MRI. Similarly, out of 15 cases diagnosed as joint effusion, only 5cases (33.33%) are detected on plain radiograph, but all the 12 cases (100%) are detected on MRI. The remaining 100% pathologies are observed on X-ray and MRI; moreover, MRI helps to improve the identification of articular cartilage, epiphysis, and additional soft tissue articular anomalies. Conclusion: MRI is a better way to identify joint effusion and synovial proliferation. Unlike standard x-rays. In proven cases with clear radiography such as Perthe’s and metastatic disease, Hip MRI helps to enhance disease staging, clinical implication, and soft tissue expansion. }, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Ravi_2021, title = {Extrapulmonary tuberculosis: are we barking up the wrong tree? A 4-yr naturalistic follow up study}, author = {Ganji Ravi and Bushra Khan and Mohammed Jalaluddin and Haneefa Khan and Swaroopa Ganji}, url = {https://www.ijsurgery.com/index.php/isj/article/view/6804/4368}, doi = {10.18203/2349-2902.isj20205889 }, issn = {2349-2902}, year = {2020}, date = {2020-12-28}, urldate = {2020-12-28}, journal = {International Surgery Journal}, volume = {8}, issue = {1}, pages = {253-260}, abstract = {Background: Aim of the study was to determine if extra-pulmonary tuberculosis (EPTB) is a communicable disease as commonly perceived or a disease of host immune dysfunction. Methods: Patients with clinical suspicion of EPTB, in general surgery and orthopaedic department of twin hospitals of Deccan College of Medical Sciences, between the period of January 2015 and December 2017, were investigated appropriately and those found to have confirmed TB were enrolled in the study and followed up for 1 year. Simultaneously patient’s details registered under RNTCP in the two local community health centres were collected and compared with the hospital based study. Results: Of 319 patients with clinical features, 267 were confirmed with EPTB- maximum number with lymph nodal disease (127) followed by extremity bone and joint (63), spine (38), skin and soft tissues (25) and abdominal tb (19). Method of confirmation differed for each site. Detection by AFB being the least sensitive followed by AFB culture. The best method of diagnosis being histopathological examination. Conclusions: Immunity plays a major role in site of reactivation of TB and healing of disease irrespective of duration of anti-tuberculous chemotherapy or surgical intervention.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Muddassir_2020, title = {Intracranial abscess and proteus mirabilis: a case report and literature review}, author = {Rabia Muddassir and Asfandyar Khalil and Romil Singh and Shafaq Taj and Zoha Khalid}, url = {https://www.cureus.com/articles/48321-intracranial-abscess-and-proteus-mirabilis-a-case-report-and-literature-review#!/}, doi = {10.7759/cureus.12326}, issn = {2168-8184}, year = {2020}, date = {2020-12-27}, urldate = {2020-12-01}, journal = {Cureus}, volume = {12}, issue = {12}, pages = {e12326}, publisher = {Cureus, Inc.}, abstract = {An intracranial abscess caused by Proteus mirabilis is rarely reported in adults. A 17-year-old girl presented with generalized tonic-clonic seizure, high-grade fever, headache, and vomiting with a history of slowly progressing apathy, clumsiness, and disorientation. She had meningeal signs and altered sensorium with a Glasgow Coma Scale of 10. The laboratory analysis revealed leukocytosis and elevated erythrocyte sedimentation rate. Brain computed tomography (CT) revealed a cystic lesion in the left temporal lobe with perilesional edema and a slight midline shift. She was commenced on empiric ceftriaxone, amikacin, and metronidazole. The non-foul smelling pus was drained through a craniotomy, and pus culture showed P. mirabilis. Culture sensitivity revealed extended-spectrum B-lactamase production, and she was commenced on intravenous carbapenem in addition to existing drugs. A repeat CT revealed a significant reduction in abscess size, and improvement in her condition was observed. On her recent follow-up visit, she was doing well.}, key = {pmid33520524}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ansari_2020, title = {Detection of carbapenemase production by RAPIDEC Carba-NP test among gram negative isolates in a tertiary care hospital}, author = {Sabina Ansari and Maimoona Mustafa and Mohammed Khaleel}, url = {https://saspublishers.com/media/articles/SJAMS_812_2814-2817.pdf}, doi = {10.36347/sjams.2020.v08i12.025 }, issn = {2320-6691}, year = {2020}, date = {2020-12-24}, urldate = {2020-12-24}, journal = {Scholars Journal of Applied Medical Sciences}, volume = {8}, issue = {12}, pages = {2814-2817}, abstract = {Introduction: The spread of carbapenemase producers by Gram negative bacteria has been a cumbersome issue. Several phenotypic and genotypic tests are present for detection of carbapenemases but are time consuming, require expertise and well established laboratory. This study aims at detection of carbapenemase production by using Rapid turnaround time test Rapidec Carba NP. This test is based on the detection of carbapenem hydrolysis by carbapenemase producing bacteria. Hydrolysis acidifies the medium which results in color change of the pH indicator. Materials and Methods: A prospective study of six months duration was done among 150 gram negative bacterial isolates obtained from various clinical samples in a tertiary care hospital. Resistance to carbapenem was detected using Meropenem disk (10μg) by kirby bauer disc diffusion method. Rapidec Carba NP test were carried out on all these carbapenem-resistant GNB isolates. Results: Among 150 Gram negative isolates 29(19%) showed resistance to Meropenem were subjected to Rapidec carba np. 93% (27/29) showed the presence of carbapenemase by Rapidec Carba NP test. Among the carbapenem resistant GNB isolates, 48.27% (14/29) were Klebsiella pneumoniae, 24.13% (7/29) were Escherichia coli, 20.68% (6/29) were Pseudomonas aeruginosa and 6.89% (2/29) were Acinetobacter baumanni. Conclusion: Rapidec Carba NP was sensitive enough to confirm carbapenemase producing isolates within a short time of less than<2h accurately. }, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Bengaluri_2021b, title = {Salvage procedures in post-polio residual paralysis (PPRP) with or without arthritis}, author = {Ramesh Bengaluri and C. Rahul Reddy and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2021/vol7issue1/PartK/7-1-93-263.pdf}, doi = {10.22271/ortho.2021.v7.i1k.2559}, issn = {2395-1958}, year = {2020}, date = {2020-12-21}, urldate = {2020-12-21}, journal = {International Journal of Orthopaedics Sciences}, volume = {7}, issue = {1}, pages = {681-683}, abstract = {Poliomyelitis is a rare disease at present, but presentation with its sequalae is not uncommon. In this study we are presenting 5 different cases with 5 different deformities in lower limb, who were managed with arthrodesis, tendon transfer, and osteotomies in combination. All the 5 patients were satisfied with their gait and pain relief after surgery compared with pre-operative status. All patients were followed for period of 2 years post operatively, no major complications were encountered. In conclusion, because of gross muscle power compromise replacement surgeries will not give good results in post residual paralysis patients, so salvage procedures definitely improve the performances of patients with painful unstable joints. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Gangani_2020, title = {Arrhythmia in tumor lysis syndrome and associated in-hospital mortality: a nationwide inpatient analysis}, author = {Kishorbhai Gangani and Hee K. Fong and Mohammed Faisaluddin and Muhammad U. Lodhi and Pritika Manaktala and Ashish Sadolikar and Vraj Shah and Zainab Gandhi and Falah Abu Hassan and Sejal Savani and Rajkumar Doshi and Rupak Desai}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/joa3.12482}, doi = {10.1002/joa3.12482}, issn = {1880-4276}, year = {2020}, date = {2020-12-18}, urldate = {2020-12-01}, journal = {Journal of Arrhythmia}, volume = {37}, issue = {1}, pages = {121-127}, publisher = {Wiley}, abstract = {Background: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency associated with fatal complications including arrhythmia. The epidemiology and mortality outcomes of arrhythmia in TLS are scarcely studied in the literature. Methods: We used the National Inpatient Sample (NIS) to study the prevalence and outcome of arrhythmia in patients hospitalized with TLS (ICD-9 code 277.88) from 2009 to 2014. Baseline characteristics, burden of arrhythmia, and pertinent outcomes were analyzed. Multivariable regression analysis was performed to identify the impact of underlying malignancy in predicting TLS-related mortality. Results: A total of 9034 cases of arrhythmia among 37 861 TLS patients were identified. More than half of the arrhythmia cases (67%) were found among white old (>65) males admitted to large bed size and urban teaching hospitals. Arrhythmic cohort showed higher frequency of comorbidities such as fluid-electrolyte disturbances, hypertension, congestive heart failure, renal failure, dyslipidemia, diabetes, pulmonary circulatory disorders, chronic pulmonary disease, coagulopathy, and deficiency anemia. The most common malignancies were leukemia, lymphoma, metastatic tumor, and solid tumor without metastasis. We found significantly higher odds of in-hospital mortality among patients with TLS compared to general inpatient population on unadjusted (OR 9.69, 95% CI: 9.27-10.13, P < .001) and adjusted (OR 4.62, 95% CI: 4.39-4.85) multivariable analyses. Overall in-hospital mortality (32% vs 21.3%), median length of stay (11 days vs 9 days), and hospital charges were higher among arrhythmic than nonarrhythmic patients. Conclusion: With the availability of more advanced cancer therapy in the US, nearly one in four inpatient encounters of TLS had arrhythmia. Arrhythmia in TLS patients was associated with higher odds of mortality and increased resource utilization. Therefore, strategies to improve the supportive care of TLS patients plus timely diagnosis and treatment of arrhythmia are of utmost importance in reducing mortality and health-care cost.}, key = {pmid33664894}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2020d, title = {Contemporary trends and outcomes in patients with ST-segment elevation myocardial infarction and end-stage renal disease on dialysis: insight from the National Inpatient Sample}, author = {Muhammad Zia Khan and Moinuddin Syed and Mohammed Osman and Mohammed Faisaluddin and Samian Sulaiman and Peter D. Farjo and Muhammad U. Khan and Pratik Agrawal and Anas Alharbi and Safi U. Khan and Muhammad Bilal Munir and Sudarshan Balla}, url = {https://www.sciencedirect.com/science/article/abs/pii/S1553838920302517?via%3Dihub}, doi = {10.1016/j.carrev.2020.05.004}, issn = {1553-8389}, year = {2020}, date = {2020-12-16}, urldate = {2020-12-01}, journal = {Cardiovascular Revascularization Medicine}, volume = {21}, issue = {12}, pages = {1474-1481}, publisher = {Elsevier BV}, abstract = {Background: Cardiovascular disease is the major cause of mortality in end stage renal disease (ESRD) patients on dialysis and myocardial infarction constitutes almost 20% of such deaths. We assessed the trends, characteristics and in-hospital outcomes in patients with ESRD. Methods: We used national inpatient sample (NIS) to identify patients with ESRD presenting with ST-segment elevation myocardial infarction (STEMI) for calendar years 2012–2016. Multiple logistic regression analysis and propensity matched data was used to compare outcomes for the purpose of our study. Results: Patients on dialysis who presented with STEMI were less likely to be treated with emergent reperfusion therapies including percutaneous coronary intervention, bypass graft surgery and thrombolytics with in first 24 h. In propensity-matched cohort, the mortality was nearly double in patients who have ESRD compared to patients without ESRD (29.7% vs. 15.9%, p < 0.01). In-patient morbidity such as utilization of tracheostomy, mechanical ventilation and feeding tubes was also more prevalent in propensity matched ESRD cohort. In multivariate regression analysis, ESRD remains a strong predictor of increased mortality in STEMI patients (OR 2.65, 95% CI, 2.57–2.75, p < 0.01). Conclusion: Our study showed low utilization of evidence-based prompt reperfusion therapies in ESRD patients with STEMI along with concomitant increased poor outcomes and resource utilization. Future research specifically targeting this extremely high-risk patient population is needed to identify the role of prompt reperfusion therapies in improving outcomes in these patients.}, key = {pmid32444271}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2020, title = {Biofabrication of cell-laden allografts of goat urinary bladder scaffold for organ reconstruction/regeneration}, author = {Sandeep Kumar Vishwakarma and Shahana Sarwar and Mohammed Abdul Majid Adil and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S004081662030433X?via%3Dihub}, doi = {10.1016/j.tice.2020.101443}, issn = {0040-8166}, year = {2020}, date = {2020-12-01}, urldate = {2020-12-01}, journal = {Tissue and Cell}, volume = {67}, pages = {101443}, publisher = {Elsevier BV}, abstract = {Introduction: Bladder dysfunction has been considered as one of the most critical health conditions with no proper treatment. Current therapeutic approaches including enterocystoplasty have several limitations. Hence, biofabrication of cell-laden biological allografts using decellularized Goat urinary bladder scaffolds for organ reconstruction/regeneration was major objective of this study. Materials and methods: An efficient method for decellularization of Goat urinary bladder (N = 3) was developed by perfusion of gradient change of detergents through ureter. The retention of organ architecture, extracellular matrix composition, mechanical properties and removal of cellular components was characterized using histological, cellular and molecular analysis. Further, mesenchymal stem cells (MSCs) from human umbilical cord blood (UCB) were used for preparing biological construct of decellularized urinary bladder (DUB) scaffolds to augment the urinary bladder reconstruction/regeneration. Results: The decellularization method adopted in this study generated completely DUB scaffolds within 10 h at 100 mm Hg pressure and constant flow rate of 1 mL/min. The DUB scaffold retains organ architecture, ECM composition, and mechanical strength. No significant amount of residual nucleic acid was observed post-decellularization. Furthermore, MSCs derived from human UCB engrafted and proliferated well on DUB scaffolds in highly aligned manner under xeno-free condition. Conclusion: Biofabricated humanized urinary bladder constructs provides xeno-free allografts for future application in augmenting urinary bladder reconstruction/regeneration with further development.}, key = {pmid32998076}, keywords = {Biochemistry, Central Research Laboratory, Urology}, pubstate = {published}, tppubtype = {article} } @article{Siddiquie_2020, title = {Fear of COVID-19: a cross-sectional study among general population in Telangana during lockdown}, author = {Shadma Siddiquie and Mazher Ali and Khan Mohammed Zeeshan Ali and Khaja Shakeeb Ahmed Atif and Minhajzafar Nasirabadi}, url = {https://journals.lww.com/tjpy/abstract/2020/06020/fear_of_covid_19__a_cross_sectional_study_among.13.aspx}, doi = {10.18231/j.tjp.2020.034}, issn = {2455-8559}, year = {2020}, date = {2020-12-01}, urldate = {2020-12-01}, journal = {Telangana Journal of Psychiatry}, volume = {6}, issue = {2}, pages = {170-175}, abstract = {Background: The Novel Coronavirus-19, emerged from Wuhan, China, spread throughout the world. This pandemic with its influence on each and every aspect of life, posed a much greater impact on mental health. Heightened level of anxiety, fear of contracting the virus, future uncertainties are commonly seen among general population during pandemics. Aim: To assess the fear of COVID-19 among general population of Telangana during lockdown period in India. Materials and Methods: An online survey was conducted using Google Forms. Fear of Covid-19 scale was used for assessment. Non probability snow ball sampling technique was used for collecting data. Results: A total of 245 responses were received, of which 10 responders had pre-existing psychiatric illness and were excluded. Of the remaining 235 participants, 47.2% were females and 52.8% were males. Mean age was 31.46 ± 9.82 years. 54% were educated till post-graduate level. 51.1% were married. 32% were health care professionals and involved in essential care services. The mean score of Fear of Covid-19 scale was 14.27 ± 4.29. 74.9% participants had fear of Covid-19. 61.7% felt uncomfortable when thinking about the novel Corona virus. More than 39.6% candidates were distressed on hearing/watching news about Covid-19. Around 13% participants reported disturbance in their sleep due to worry of getting infected with Corona virus. Findings imply that there was fear of Covid-19 spread among general population of Telangana during lockdown period.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Syeda_2020, title = {Experimental evaluation of antidiabetic effect of punica granatum peel extract against streptozotocin induced diabetes in albino rats}, author = {Shakira Fathima Syeda and Mohammed Mohsin}, url = {https://www.ijpbs.net/abstract.php?article=NjkxNw==}, doi = {10.22376/ijpbs.2020.11.4}, issn = {0975-6299}, year = {2020}, date = {2020-12-01}, urldate = {2020-12-01}, journal = {International Journal of Pharma and Bio Sciences}, volume = {11}, issue = {4}, pages = {115-121}, abstract = {Diabetes mellitus is a disease characterised by derangement in carbohydrate, protein and fat metabolism which is caused by the complete or relative insufficiency of insulin secretions. Plants and their bioactive constituents are used for the treatment of diabetes mellitus throughout the world; especially in countries where access to the conventional treatment of diabetes mellitus is inadequate. The present study was undertaken to investigate the anti-diabetic effect of Punica granatum ethanolic peel extract in STZ induced diabetic rat. STZ was used to induce diabetes in albino rats weighing 150-250 grams. The fasted diabetic rats were divided in to 6 groups of 6 animals each. Group I Normal control group received distilled water 5 ml/kg body weight orally daily, Group II were treated with STZ 50mg/kg body weight induced diabetic rats were served as diabetic control group and were treated with distilled water orally daily until diabetes occur, Group III i.e STZ induced diabetic rats were served as standard group and were treated with Glibenclamide at a dose of 0.5 mg/kg body weight orally daily. Group IV & Group V Punica granatum ethanolic peel extract was administered with 100mg/kg and 200mg/kg dose orally. This study was conducted over a period of 15 days with oral administration of drugs and the plant extract which was started on the 6th day of STZ treatment. The fasting blood glucose levels were determined on day 0, 5th, 10th, and 15th day by using glucometer. The maximum reduction in Blood Glucose level was observed at a dose of 200mg/kg body weight. Data were statistically analyzed by Student “t” Test. P<0.001 was considered as highly significant.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2020, title = { Histopathological spectrum of endometrial biopsies in a tertiary care hospital: a retrospective institutional study}, author = {Mehveen Rahim Khan and Abdul Wase and Nabila Afsar and Atiya Begum}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/histopathological-spectrum-of-endometrial-biopsies-in-a-tertiary-care-hospital--a-retrospective-institutional-study_December_2020_0777706621_4527162.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-12-01}, urldate = {2020-12-01}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {12}, pages = {37-39}, abstract = {Endometrial biopsies are obtained for a number of reasons that include abnormal uterine bleeding in certain age groups, incomplete abortions, or suspected neoplasia and the endometrium may be sampled prior to certain procedures to treat infertility to determine the phase of the cycle to guide further tests or treatments. The study is a retrospective cross-sectional study carried out in the Department of Pathology of Owaisi hospital and research centre , on specimens received over a one-year period. 200 Samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding received to the histopathology laboratory were analyzed. Patients were categorized into reproductive age groups (18-40 yrs), perimenopausal (41-50), and postmenopausal (>50yrs). Most common lesion is endometrial hyperplasia comprising 61% of total cases. The next common lesion is Endometrial polyp which accounts for 29% of total cases. 2 cases of Endometrial carcinoma were found which comprised of 1% of total cases. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Osman_2021, title = {A meta-analysis of intravenous iron therapy for patients with iron deficiency and heart failure}, author = {Mohammed Osman and Moinuddin Syed and Sudarshan Balla and Babikir Kheiri and Mohammed Faisaluddin and Christopher Bianco}, url = {https://www.ajconline.org/article/S0002-9149(20)31284-4/fulltext#articleInformation}, doi = {10.1016/j.amjcard.2020.11.025}, issn = {0002-9149}, year = {2020}, date = {2020-11-28}, urldate = {2021-02-01}, journal = {The American Journal of Cardiology}, volume = {141}, pages = {152-153}, publisher = {Elsevier BV}, abstract = {Iron deficiency is highly prevalent among heart failure patients and is associated with worse quality of life and a higher risk of hospitalizations and mortality. Early randomized clinical trials (RCTs) evaluating the efficacy of intravenous iron replacement in heart failure patients with iron deficiency showed promising results in improving objective clinical outcomes, including heart failure hospitalizations and cardiovascular mortality. However, they were not explicitly powered for these outcomes. The 2017 ACC/AHA/HFSA focused guideline update provides a IIb recommendation for intravenous iron repletion in NYHA class II and III heart failure patients and iron deficiency to improve functional status and quality of life. Most recently, the results of the AFFIRM-AHF (A Randomized, Double-blind Placebo-Controlled Trial Comparing the Effect of Intravenous Ferric Carboxymaltose on Hospitalisations and Mortality in Iron Deficient Subjects Admitted for Acute Heart Failure) was presented in the American Heart Association Scientific Sessions and has refueled the interest regarding the utility of intravenous iron therapy in patients with heart failure. We aimed to pool results from all randomized controlled trials evaluating the efficacy of intravenous iron in improving cardiovascular outcomes in patients with heart failure with reduced ejection fraction (HFrEF).}, key = {pmid33259800}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020c, title = {Bacterial expedition into brain}, author = {M. V. Raghavendra Rao and R. K. Kudari and Mohammed Khaleel and Witson Paul and Dilip Mathai and Srinivasa Rao and Anjali Vasudevan and Abrar A. Khan and Mahendra Kumar Verma and Adarsh Meher Nisanth}, url = {http://journalcmpr.com/sites/default/files/issue-files/2368-A-2020.pdf}, doi = {10.24327/23956429.ijcmpr202011924}, issn = {2395-6429}, year = {2020}, date = {2020-11-28}, urldate = {2020-11-28}, journal = {International Journal of Current Medical and Pharmaceutical Research}, volume = {6}, issue = {11(A)}, pages = {5388-5394}, abstract = {Infections of the Central nervous system (CNS) account for significant morbidity and mortality. Most of the infections present as a medical emergency; need prompt treatment. The CNS consistes of brain and spinal cord; covered by three layers of meninges-duramater (outermost) arachnoid and piamater (latter two are called leptomeninges). Meningitis is an inflammation of leptomeninges surrounding the brain and spinal cord, with involvement of the subarachnoid space. The agents implicated in pyogenic meningitis may vary according to age. Meningitis in neonates and infants caused by E.coli, Group B Streptococci (Streptococcus agalactiae), Streptococcus pneumoniae, Listeria monocytogenes. In children, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, where as in adults Neisseria meningitidis, Streptococcus pneumoniae produce meningitis. The most common meningitis causing bacteria are, Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis. The bacteria enter into the body through throat. The infection is transmitted from person- to- person through droplets of respiratory sections from cases or nasopharyngeal carriers. Organisms may gain access to the meninges by several routes such as hematogenous, direct spread from an infected site or anatomical defect in central nervous system causing causing fever, chills and rash, soon these bacteria settle in meninges causing inflammation. This causes pressure in head, and the patient feels severe headache. Neck becomes stiff. The patient often becomes confused or even unconscious the patient may have convulsions which are twitching and jerking of the body that cannot control.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Gad_2020, title = {Epidemiology of cholangiocarcinoma; United States incidence and mortality trends}, author = {Mohamed M. Gad and Anas M. Saad and Mohammed Faisaluddin and Mihnea Alexandru Gaman and Inas A. Ruhban and Khalid A. Jazieh and Muneer J. Al-Husseini and Carlos Roberto Simons-Linares and M. Bassam Sonbol and Bassam N. Estfan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S2210740120300991?via%3Dihub}, doi = {10.1016/j.clinre.2020.03.024}, issn = {2210-7401}, year = {2020}, date = {2020-11-21}, urldate = {2020-11-01}, journal = {Clinics and Research in Hepatology and Gastroenterology}, volume = {44}, issue = {6}, pages = {885-893}, publisher = {Elsevier BV}, abstract = {Background: Cholangiocarcinoma is an aggressive malignancy with few available studies assessing incidence and mortality. In this study, we aim to investigate trends of incidence and mortality in a large nation-wide epidemiologic study. Methods: We used SEER 18 database to study cholangiocarcinoma cases in the US during 2000-2015. Incidence and mortality rates of cholangiocarcinoma were calculated by race and were expressed by 1,000,000 person-years. Annual percent change (APC) was calculated using joinpoint regression software. Results: We reviewed 16,189 patients with cholangiocarcinoma, of which 64.4% were intrahepatic. Most patients were whites (78.4%), males (51.3%), and older than 65 years (63%). A total of 13,121 patients died of cholangiocarcinoma during the study period. Cholangiocarcinoma incidence and mortality were 11.977 and 10.295 and were both higher among Asians, males, and individuals older than 65 years. Incidence rates have significantly increased over the study period (APC = 5.063%, P < .001), while mortality increased significantly over the study period (APC = 5.964%, P < .001), but decreased after 2013 (APC = −25.029, P < .001). Conclusion: The incidence and mortality of cholangiocarcinoma were increasing in the study period with significant observed disparities based on race and gender.}, key = {pmid32359831}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Chobufo_2020, title = {10-year community prevalence and trends of severe asymptomatic hypertension among patients with hypertension in the USA: 2007–2016}, author = {Muchi Ditah Chobufo and Ebad Ur Rahman and Farah Fatima and Mohamed Suliman and Kanaan Mansoor and Adee Elhamdani and Mehiar El-Hamdani and Sudarshan Balla}, url = {https://www.sciencedirect.com/science/article/pii/S2590086220300434?via%3Dihub}, doi = {10.1016/j.ijchy.2020.100066}, issn = {2590-0862}, year = {2020}, date = {2020-11-03}, urldate = {2020-11-03}, journal = {International Journal of Cardiology Hypertension}, volume = {7}, pages = {100066}, publisher = {Elsevier BV}, abstract = {Background: Severe asymptomatic hypertension (SAH) is associated with significant health cost, morbidity and mortality. Aim: Establish the nationwide prevalence, trends and associated sociodemographic characteristics of SAH among patients with hypertension in the USA. Methods: We utilized the National Health and Nutrition Examination data collected over five survey cycles (2007–2016). Included were participants aged 20–80 years with self-reported diagnosis of hypertension. SAH was defined as having a mean systolic blood pressure (SBP) ≥180 mmHg and/or mean diastolic blood pressure (DBP) ≥120 mmHg at the time of examination. The Chi square test was used to compare prevalence across different categories. Associations between sociodemographic variables and SAH were assessed using multivariate binary logistic regression. Results: The prevalence of SAH among patients with hypertension is 2.15% (95% CI 1.80–2.56), mainly explained by isolated mean SBP≥180 mmHg (86% of all cases), with no statistically significant change between 2007: 2.66% (95% CI 2.10–3.36) and 2016:2.61% [95% CI 1.73–3.94)}, key = {pmid33447787}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2020b, title = {Abdominal wall metastases of hepatocellular carcinoma-an unusual presentation}, author = {Mehveen Rahim Khan and Nabila Afsar and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/abdominal-wall-metastasis-of-hepatocellular-carcinomaan-unusual-presentation_November_2020_0418414166_1229394.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-11-01}, urldate = {2020-11-01}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {11}, pages = {52-53}, abstract = {We report a case of 60 year old male with a swelling in the right iliac fossa which presented as desmoid tumour clinically and was later found to be metastasis from hepatocellular carcinoma.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2020, title = {Distribution of blood group type in diagnosed NS1Ag positive dengue patients in Hyderbad,Telangana State}, author = {Adiba Siddiqui and Nabiha Tabassum and Nabila Afsar and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/distribution-of-blood-group-type-in-diagnosed-ns1-ag-positive-dengue-patients-in-hyderabad-telengana-state-india_November_2020_7061945912_4335125.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-11-01}, urldate = {2020-11-01}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {11}, pages = {41-42}, abstract = {The aim of this study was to determine the distribution of blood group type in diagnosed NS1Ag positive dengue cases. The ABO phenotypes were identified by use of blood from patients with dengue virus infection prospectively, in newly diagnosed patients at a tertiary care hospital in south India. A total of 162 NS1Ag positive cases were collected with dengue illness. The greatest number (25%) of dengue cases were seen in the 11-20 year age group. Males were predominantly effected(58%). It was found that majority (45%) of cases belonged to blood group O.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Kousik_2020, title = {An unusual case of anterior abdominal wall dialysate leak diagnosed with Tc99m-sulfur colloid single-photon emission computed tomography/computed tomography peritoneal scintigraphy}, author = {Vankadari Kousik and Rajendra Prasad and Randheer Kumar}, url = {https://journals.lww.com/ijnm/fulltext/2020/35040/an_unusual_case_of_anterior_abdominal_wall.25.aspx}, doi = {10.4103/ijnm.ijnm_89_20}, issn = {0972-3919}, year = {2020}, date = {2020-10-21}, urldate = {2020-01-01}, journal = {Indian Journal of Nuclear Medicine}, volume = {35}, issue = {4}, pages = {370-371}, publisher = {Medknow}, abstract = {Peritoneal dialysis (PD) was commonly used renal replacement therapy for treating end-stage renal failure patients leading to various infectious and mechanical complications. We present a case of a 50-year-old female patient who presented with reduced dialysate return and abdominal wall edema following continuous ambulatory PD. Peritoneal scintigraphy done on suspicion of dialysate leak shows tracer accumulation in the anterior abdominal wall below the insertion of the peritoneal catheter.}, key = {pmid33642774}, keywords = {Urology}, pubstate = {published}, tppubtype = {article} } @article{Hashmi_2020, title = {Morphological spectrum and pathological parameters of type 2 endometrial carcinoma: a comparison with type 1 endometrial cancers}, author = {Atif A. Hashmi and Syeda N. Iftikhar and Javaria Ali and Fatima Shaheen and Farhath Afroze and Abira Imran}, url = {https://www.cureus.com/articles/43167-morphological-spectrum-and-pathological-parameters-of-type-2-endometrial-carcinoma-a-comparison-with-type-1-endometrial-cancers#!/}, doi = {10.7759/cureus.11025}, issn = {2168-8184}, year = {2020}, date = {2020-10-18}, urldate = {2020-10-18}, journal = {Cureus}, volume = {12}, issue = {10}, pages = {e11025}, publisher = {Cureus, Inc.}, abstract = {Introduction: Endometrial cancers (ECs) are the most common gynecological malignancies. Based on morphology and pathogenesis, ECs are segregated into type 1 and 2 ECs. Types 1 ECs are those tumors that are estrogen-driven, whereas type 2 ECs are more aggressive and are independent of hormonal status. In the proposed study, we evaluated the clinicopathological parameters of type 2 ECs and its comparison with type 1 ECs. Methods: We retrospectively analyzed seven-year data from archives of pathology, Liaquat National Hospital, from January 2013 to December 2019. All patients underwent radical surgeries for diagnosed EC on endometrial biopsy. All specimens were of total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and peritoneal sampling, along with pelvic lymphadenectomy. Records regarding tumor type, grade, depth of myometrial invasion, and ovarian, omental, nodal, and parametrial involvement were assessed. Results: A total of 129 cases of ECs were included in the study. The mean age of the patients was 57.6 ± 9.3 years. Majority of the cases were type 1 ECs (82.2%). The most common histological type of EC was endometrioid (82.2%) followed by serous carcinoma (10.1%). Most of the tumors were grade 1 (42.6%) and the International Federation of Gynecology and Obstetrics (FIGO) stage I (72.8%). Nodal metastases were present in eight cases (6.2%) and adnexal involvement was present in 12 cases (9.3%). We found a significant association of the type of EC with lymphovascular invasion, nodal metastasis, and adnexal involvement, whereas no significant association of EC type was seen with other clinicopathological characteristics. Conclusions: Type 1 EC was the most frequent subtype of EC in our study. On the other hand, type 2 EC was significantly associated with nodal metastasis, lymphovascular invasion, and adnexal involvement, signifying the poor prognostic significance of this group of EC.}, key = {pmid33214953}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2020e, title = {A rare case of sarcoidosis with complete bronchial obstruction}, author = {Abdul K. Khan and Akriti Jain and Mohammed Faisaluddin and Francisco Almeida and Manuel F. Betancourt}, url = {https://journals.lww.com/bronchology/fulltext/2020/10000/a_rare_case_of_sarcoidosis_with_complete_bronchial.18.aspx}, doi = {10.1097/lbr.0000000000000677}, issn = { 1944-6586}, year = {2020}, date = {2020-10-01}, urldate = {2020-09-01}, journal = {Journal of Bronchology & Interventional Pulmonology}, volume = {27}, issue = {4}, pages = {e59-e62}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, abstract = {Sarcoidosis is a multisystemic disorder of unknown etiology characterized pathologically by noncaseating granulomatosis. Aggressive bronchial involvement with sarcoidosis is rare and contributes significantly to the morbidity.1 We describe a case of sarcoidosis with extensive bronchial inflammation causing complete airway obstruction.}, key = {pmid32960862}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Farooqui_2020, title = {A comparative evaluation of antiplatelet regimens for prevention of recurrence in patients with ischemic stroke: a pilot study}, author = {Sadia Farooqui and S. Arfaa and S. Nousheen and S. Fatima and Mohammed Zoheb}, url = {https://ijpsr.com/bft-article/a-comparative-evaluation-of-antiplatelet-regimens-for-prevention-of-recurrence-in-patients-with-ischemic-stroke-a-pilot-study/}, doi = {10.13040/IJPSR.0975-8232.11(10).5071-75 }, issn = {0975-8232}, year = {2020}, date = {2020-10-01}, urldate = {2020-10-01}, journal = {International Journal of Pharmaceutical Sciences and Research}, volume = {11}, issue = {10}, pages = {5071-5075}, abstract = {Background: Prevention of recurrence is important for patients with ischemic stroke. The purpose of the study was to compare the effectiveness of two antiplatelet regimens-aspirin plus clopidogrel versus aspirin plus cilostazol in early secondary stroke prevention using National Institutes of Health Stroke Scale (NIHSS) Scores. Methods: In this study, we randomly assigned 30 patients to receive aspirin plus clopidogrel once daily or to receive aspirin once daily plus cilostazol twice daily. The patients were followed up for a period of three months, and the NIHSS scores were taken on admission, and every month thereafter. After completion of the study duration, the scores of both the groups were compared, and results were interpreted. Results and Discussion: More number of patients were found to be in the age group of 60- 70 years with a mean age of 63 years. In both the groups, the percentage of females was higher than that of males. Hypertension (80%) and diabetes mellitus (56.6%) appeared to be the major risk factors. The percentage of death rate in the aspirin/clopidogrel group (20.25%) was higher than that of the aspirin/cilostazol group (6.75%). Recurrent stroke and vascular events did not occur in any group. Conclusion: Aspirin/cilostazol significantly reduced the risk of early stroke recurrence based on NIHSS scores. Hence, it can be considered as a supplement to aspirin or an alternative to clopidogrel in dual therapy for secondary prevention of ischemic stroke. There is no evidence that either of the two antiplatelet regimens was superior to the other in the prevention of recurrent stroke.}, keywords = {Deccan School of Pharmacy, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Afsar_2020, title = {Role of neutrophil lymphocyte ratio as a prognostic marker of dengue}, author = {Nabila Afsar and Hina Sayeed and Fawwad M. Shaikh and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-dengue_October_2020_6114171606_8732160.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-10-01}, urldate = {2020-10-01}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {10}, pages = {67-68}, abstract = {INTRODUCTION: Dengue is an important arthropod-borne viral infection in humans and is the second most important re-emerging tropical disease in the past 20 years all over the globe. Aim: To study neutrophil lymphocyte ratio in dengue cases and assess its role in relation with various demographic, serologic parameters and platelet count. MATERIAL AND METHODS: A retrospective study of 100 dengue cases admitted in a tertiary care hospital in South India during the monsoon season of 2019 was carried out. Clinical data and CBC results were reviewed and analysed. The Chi Square test was used to compare categorical variables. RESULTS: Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. Neutrophil Lymphocyte ratio(NLR) <2 strongly correlates with low platelets indicating severity of disease and reversal of NLR >2 correlates with improvement of disease. NLR <2 was more common in 0-20 years age group, younger the age lesser the Neutrophil Lymphocyte ratio and hence more severe the disease. CONCLUSION: Neutrophil Lymphocyte ratio acts as a prognostic indicator in dengue cases.}, keywords = {Community Medicine, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Jaanbasha_2020, title = {Role of tranexamic acid (TXA) administered locally into the surgical site intraoperatively in reducing the post-operative blood loss in hip arthroplasty}, author = {Md. Jaan Basha and Chavva Shamsundar and Lalitmohan}, url = {https://www.orthopaper.com/archives/?year=2020&vol=6&issue=4&part=J&ArticleId=2404}, doi = {10.22271/ortho.2020.v6.i4j.2404}, issn = {2395-1958}, year = {2020}, date = {2020-10-01}, urldate = {2020-10-01}, journal = {International Journal of Orthopaedics Sciences}, volume = {6}, issue = {4}, pages = {679–681}, publisher = {AkiNik Publications}, abstract = {Total hip arthroplasty (THA) has revolutionized the quality of life of men and women of all ages since the 1960s, earning the title of “the operation of the century. Being a measure surgery there is considerable loss of blood in intra and post operative period along with drop in the level of hemoglobin. Average blood loss is around 1000ml (450 to 1900ml) and the mean hemoglobin fall is 2.1 ± 1.1 g/dl. There are various methods available to control and decrease the blood loss intra and post operatively. Systemic administration of tranexamic acid has been studied and its effectiveness being proved in literature and commonly being used in orthopedics, gynecology and neuro surgery. But, Administration and the effects of tranexamic acid into the operative site haven’t been published in literature, to the best of our knowledge. Present study is based on the estimation of effectiveness of TXA at the surgical site after wound closure.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Hidayathulla_2020, title = {A prospective study of benefits and risk of paclitaxel drug in the treatment of femoropopliteal artery disease}, author = {Mohammed Hidayathulla and Syed Azhar Ali and Syeda Tasneem Kausar}, url = {https://ejmcm.com/uploads/paper/5449bd7638f1d78a6d43ec2420c67ca8.pdf}, issn = {2515-8260}, year = {2020}, date = {2020-09-30}, urldate = {2020-09-30}, journal = {European Journal of Molecular and Clinical Medicine}, volume = {7}, issue = {9}, pages = {3588-3597}, abstract = {Introduction: Femoro-popliteal arterial disease is a common vascular condition and Various methods of revascularization have been tried which includes simple balloon angioplasty, debulking techniques , stent implantation , and recently the drug eluting balloons. Paclitaxel drug eluting balloons are more promising in the approach to treat femoro-popliteal arterial disease . Material and Methods: The present study from march 2016 to january 2018 was conducted on 25 cases prospectively in patients admitted to the Department of cardiology sri jayadeva institute of cardiovascular sciences and research center, Bangaluru (Karnataka). femoral artery using cross over sheath VascuQol – 6 disease specific health related quality of life questionnaire post procedure . Results: A success rate of 92% was recorded and patients treated with DCB showed significantly higher primary patency of the affected vessel. The current study reveals that vascuQoL-6 score used to assess the quality of life of the patient with peripheral arterial disease before and after the intervention improved and it is statistically significantly. Conclusion: We conclude that Use of paclitaxel drug coating balloon is safe and efficacious in treating femoro-popliteal arterial disease. Restenosis which was noted in 8% of our cases can be successfully managed with percutaneous transluminal angioplasty using same DCB.}, keywords = {Cardiology, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2020b, title = {Maternal outcome of pregnancies in women at the extremes of maternal age}, author = {Surayya Tahseen and Syeda Maliha Fathima and Sowmya Sri Kondeti and Nabeeha Mujtaba Ali and Fatima Tahniyath}, url = {https://storage.googleapis.com/innctech/ejbps/article_issue/volume_7_september_issue_9/1598754840.pdf}, issn = {2349-8870}, year = {2020}, date = {2020-09-30}, urldate = {2020-09-30}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {7}, issue = {9}, pages = {257}, abstract = {Background: Extremes of maternal age adversely affect pregnancy outcomes.Teenage pregnancy is regarded as a serious public health problem and often occurs in the context of poor social support and maternal well- being.Teenage pregnancy is known to be associated with adverse pregnancy outcomes such as preterm births, low birth weight deliveries and increased risk of caesarean delivery. Methods: A hospital based prospective study carried out in the Department of Obstetrics and Gynaecology from October 2013 to September 2015 at Owaisi hospital and research centre and Princess Esra Hospital, a tertiary care centre, Deccan College of medical sciences,Hyderabad. Results: Among 8640 antenatal patients who delivered during the 24 months period i.e October 2013 to September 2015 at the hospital out of these 241(2.8%) were teenage primigravida aged 15 to 19 yrs. Conclusions: In India, 10.3% of the female population belongs to the age group of l5-19 years.In 1997, the age specific fertility rate was found to be 52.5 live births per 1000 rural women aged between 15-19 years. Over the years, there has not been much improvement in the country’s scenario as reported by the National Family Health Surveys.}, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2020c, title = {Fetal and maternal outcomes of pregnancies in women at the extremes of maternal age- a review}, author = {Surayya Tahseen and Fatima Tahniyath}, url = {https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_7_september_issue_9/1598701743.pdf}, issn = {2349-8870}, year = {2020}, date = {2020-09-30}, urldate = {2020-09-30}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {7}, issue = {9}, pages = {115-123}, abstract = {Teenage pregnancy is a common public health and social problem with adverse medical consequences worldwide. WHO estimates that risk of death following pregnancy is twice as great for women between 15 to 19 years than those between 20 to 24 years.[1] The incidence of teenage pregnancy shows marked variation, in developed and developing countries .In India, incidence of teenage pregnancy varies from 3.2% to 18.6%.[2] According to the UNICEF 2011 report, the adolescent population in India is 20% of the total population i.e. almost 243 million. 27% of girls aged 15 to 19 years are married with a birth rate of 45 per 1000 girls in this age group.[3] Early Marraiges are a long established custom in India resulting in the high incidence of teenage pregnancy. The rate is higher in the rural than in urbanized areas. Despite the law, the problems of teenage marraiges and subsequent pregnancies are widely prevalent in India. The highest rate of teenage pregnancy in the world — 143 per 1,000 girls aged 15–19 years — is in sub-Saharan Africa.[4] In 2013, the teenage birth rate in the United States reached a historic low: 26.6 births per 1,000 women aged 15–19. }, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Jalees_2020, title = {Adenosine deaminase and lactate dehydrogenase levels in serum and cerebrospinal fluid of patients with tuberculous meningitis}, author = {Syeda Shahana Jalees and Syed Tamkeen Hussain}, url = {https://www.ijcbr.in/journal-article-file/12281}, doi = {10.18231/j.ijcbr.2020.088}, issn = {2394-6369}, year = {2020}, date = {2020-09-28}, urldate = {2020-09-28}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {7}, issue = {3}, pages = {411-415}, abstract = {Meningitis is an active inflammatory condition of CNS. However prompt and precise aetiological diagnosis remains a challenge. Often a thorough CSF examination may not give a precise diagnosis. There is considerable urgency in establishing correct diagnosis in patients with tuberculous meningitis because specific therapy is most effective when initiated early in course of illness, delay may cause irreversible brain damage. Diagnosis often rests on circumstantial evidence such as history, typical CSF findings and other evidence for presence of tuberculosis such as acid fast bacilli in sputum, positive tuberculosis test and suspicious Chest x-ray. Under present study the role of enzymes such as adenosine deaminase and lactate dehydrogenase has been evaluated in diagnosis of tuberculous meningitis. Result of the study suggest that adenosine deaminase level in CSF and serum may be a useful parameter along with other routine estimations. The enzyme activity is high in disease such as tuberculosis where cellular mediated immunity is stimulated. Estimation of lactate dehydrogenase levels may not be a specific parameter for tuberculous meningitis this requires further studies in patients of meningitis with different aetiological diagnosis.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Hadi_2020, title = {A study on different modalities of treatment for pilonidal sinus}, author = {Mohammed Abdul Hadi and Syed Mujtaba Ibrahim and Atif Abdul Samee}, url = {https://www.surgeryscience.com/articles/544/4-4-16-339.pdf}, doi = {10.33545/surgery.2020.v4.i4b.544}, issn = {2616-3462}, year = {2020}, date = {2020-09-21}, urldate = {2020-09-21}, journal = {International Journal of Surgery Science}, volume = {4}, issue = {4}, pages = {87-91}, abstract = {Background: Excision with lay open method and excision with primary closure (simple closure, z-plasty, limberg flaps are both radical methods for treating pilonidal sinus. The ideal operation should be simple and should not require a prolonged stay, have low recurrence, failure rate and post-operative complication. Aim& Objective: The main objective of the present study to compared different techniques for treatment of sacrococcygeal pilonidal sinus. Methodology: It was a cross sectional study. The materials for this study was taken from the patient admitted to Owaisi hospital from Jan 2013-Dec 2014 (2yr period) Twenty eight patients with pilonidal sinus who were admitted to Owaisi hospital. Results: In the present study, 15 out of 28 cases were treated by excision and lay open method. The mortality was nil, but the recurrence was 1 and 2 failures were noticed (totally 22.6% failure) in terms of morbidity. Patients abstained from work till the wound healed i.e. 44-68 days(average 49.5 days).The remaining 13 cases were operated by excision and primary closure (simple closure, z-plasty, limberg flap method) out of which 8 cases were treated with z-plasty and 2 cases with simple primary closure and 3 cases with limberg flap method. The mortality was nil, the recurrence rate and post-operative complications were nil and all patients returned to work early within 7 days. Conclusion: Finally we concluded that all cases where closure is possible should be treated with different closure techniques (simple closure, z-plasty, limberg flap). Deep gluteal cleft is flattened with z-plasty and limberg flap technique. Hence the suction effect is obliterated. All predisposing factors are countered by flap technique hence flap techniques are ideal for treatment for pilonidal sinus. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Garlapati_2020, title = {Outcomes of oesophageal variceal bleeding among patients with atrial fibrillation: a propensity-matched analysis of a nationwide inpatient sample}, author = {Pavani Garlapati and Ebad Ur Rahman and Vijay Gayam and Muchi Ditah Chobufo and Farah Fatima and Arfaat M. Khan and Mohamed Suliman and Ellen A. Thompson and Mehiar El-Hamdani and Wilbert Aronow}, url = {https://amsad.termedia.pl/pdf-126667-71887?filename=Outcomes%20of%20oesophageal.pdf}, doi = {10.5114/amsad.2020.98949}, issn = {2451-0629}, year = {2020}, date = {2020-09-14}, urldate = {2020-09-01}, journal = {Archives of Medical Science – Atherosclerotic Diseases}, volume = {5}, issue = {1}, pages = {255-262}, publisher = {Termedia Sp. z.o.o.}, abstract = {Introduction: We aimed to determine the influence of atrial fibrillation (AF) on mortality, morbidity, length of hospital stay, and resource utilisation in patients with oesophageal variceal bleeding (OVB). Material and methods: The National Inpatient Sample database (2016 and 2017) was used for data analysis using the International Classification of Diseases, Tenth Revision codes to identify patients with the principal diagnosis of OVB and AF. We assessed the all-cause in-hospital mortality, morbidity, predictors of mortality, length of hospital stay (LOS), and total costs between propensity-matched groups of OVB with AF vs. OVB alone. Results: We identified 80,325 patients with OVB, of whom 4285 had OVB with AF, and 76,040 had OVB only. The in-hospital mortality was higher in OVB with AF (OR = 1.4, 95% CI: 1.09–1.83; p < 0.001). OVB with AF had higher odds of sepsis (OR = 1.4, 95% CI: 1.1–1.8; p = 0.007), acute kidney injury (OR = 1.2, 95% CI: 1.12–1.32; p < 0.001), and mechanical ventilation (OR = 1.2, 95% CI: 1.12–1.32; p < 0.001). Advanced age (OR = 1.06, 95% CI: 1.05–1.07; p < 0.001), congestive heart failure (OR = 1.7, 95% CI: 1.3–2.3; p < 0.001), coronary artery disease (OR = 1.4, 95% CI: 1.03–1.92; p = 0.02), and sepsis (OR = 1.3, 95% CI: 1.06–1.70; p = 0.01) were identified as predictors of mortality in OVB with AF. Mean LOS (7.5 ±7.4 vs. 6.0 ±7.2, p < 0.001) and mean total costs (,452 vs. ,109, p < 0.001) were also higher. Conclusions: In this propensity-matched analysis, OVB with AF was associated with higher odds of in-hospital mortality, sepsis, acute kidney injury, and mechanical ventilation.}, key = {pmid33305064}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Afreen_2020b, title = {Single nucleotide polymorphism in the promoter region of interleukin-4 and risk of asthma: TT homozygotes may have high propensity of developing chronic airway remodeling}, author = {Arshiya Afreen and S. Farhana F. A. and Sumaya Fatima and T. K. M. Rayees and Nida Makeen and Nusrath Fathima and Ashfaq Hasan and M. Aleemuddin Naveed and Fahad Abdullah Bin Breik and Mohd. Mohiuddin and Mohammed Ishaq}, url = {https://www.ijrrjournal.com/IJRR_Vol.7_Issue.9_Sep2020/IJRR0014.pdf}, issn = {2349-9788}, year = {2020}, date = {2020-09-01}, urldate = {2020-09-01}, journal = {International Journal of Research and Review}, volume = {7}, issue = {9}, pages = {104-110}, abstract = {Background: In view of a key role played by Interleukin-4 (IL-4) in the molecular mechanisms leading to the development of asthma and its complications like chronic airway remodeling, a few reports have attempted to investigate a possible role of SNP’s in the promoter region to predict genetic risk. As it is associated with quantitative variations in IL-4 gene expression and may serve as an important candidate gene for asthma risk prediction. Objective: To investigate the polymorphic variations, at -590 (C/T) in the promoter region of IL-4 gene. Methods: 50 consecutively selected cases of asthma (36 females and 14 males) were recruited and genotyping for SNP at -590 C/T was done by PCR-RFLP method on the genomic DNA extracted from blood samples. Blood samples from 50 randomly selected healthy subjects served as controls. Mean values of Absolute Eosinophil Count and total serum IgE between the genotypes were compared by student’s unpaired t test. Odds-ratio analysis was carried out to determine risk of developing asthma. Results: Odds ratio (OR) analysis revealed two-and-a-half folds increased risk of asthma for individuals with TT genotype compared to those with CC genotype. A decreased frequency of CC genotype in patients (28%) compared to controls (58%) is indicative of protective nature of CC genotype. AEC counts and total serum IgE levels were significantly higher in TT compared to CC and CT genotypes. Conclusion: It is concluded that individuals with TT and CT genotypes (overproducers of IL-4) have high risk of developing asthma and high vulnerability to develop chronic airway remodeling.}, keywords = {Central Research Laboratory, Deccan School of Pharmacy, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Chakraborty_2020, title = {In-hospital clinical outcomes of transcatheter aortic valve replacement in patients with concomitant carotid artery stenosis: Insights from the national inpatient sample}, author = {Sandipan Chakraborty and Mohammed Faisaluddin and Kumar Ashish and Birendra Amgai and Dhrubajyoti Bandyopadhyay and Neelkumar Patel and Adrija Hajra and Gaurav Aggarwal and Raktim K. Ghosh and Ankur Kalra}, url = {https://www.sciencedirect.com/science/article/pii/S2352906720303195?via%3Dihub}, doi = {10.1016/j.ijcha.2020.100621}, issn = {2352-9067}, year = {2020}, date = {2020-09-01}, urldate = {2020-12-01}, journal = {IJC Heart & Vasculature}, volume = {31}, pages = {100621}, publisher = {Elsevier BV}, abstract = {Background: Carotid artery stenosis (CAS) is a common occurrence in elderly patients undergoing transcatheter aortic valve replacement (TAVR). We conducted a retrospective study to identify the impact of CAS on in-hospital outcomes following TAVR. Methods: We queried the National Inpatient Sample (NIS) for 2016–2017 and identified patients who underwent TAVR with concomitant CAS using the ICD-10 codes. The primary endpoint of our study was in-hospital mortality and acute ischemic stroke. Results: We identified 80,740 TAVR-related hospitalizations. Of these, 6.9% (N = 5555) patients had concomitant CAS. The mean age for CAS patients was 80 ± 7.4 years. Females were represented equally in both groups. Traditional comorbidities like dyslipidemia [78.3% (N = 4350) vs. 68.2% (N = 51261); P < 0.001] and peripheral arterial disease [27.4% (N = 1525) vs. 12.7% (N = 9526); P < 0.001] were more frequently observed among CAS patients. Patients with CAS had higher rates of previous stroke [17.5% (N = 970) vs. 11.8% (N = 8902); P < 0.001] and CABG 23.8% (N = 1320) vs. 18.6% (N = 14022); P < 0.001]. Other cardiovascular risk factors were similar between the two groups. Moreover, no differences in in-hospital outcomes including mortality [odds ratio (OR): 1.35, CI: 0.48–3.83; P = 0.57] were observed in the propensity matched cohort. Conclusions: Our study did not find any major differences in outcomes in the CAS group following TAVR; however, a more detailed randomized controlled study with long-term follow-up of these patients is needed.}, key = {pmid32939395}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Arsheen_2020, title = {Comparative study of progesterone and selective progesterone receptor modulator in treatment of fibroids}, author = {Ayesha Arsheen and Surayya Tahseen and Fatima Tahniyath}, url = {https://storage.googleapis.com/innctech/ejbps/article_issue/volume_7_august_issue_8/1596618772.pdf}, issn = {2349-8870}, year = {2020}, date = {2020-08-31}, urldate = {2020-08-31}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {7}, issue = {8}, pages = {649-656}, abstract = {Uterine fibroids (UF), also known as Leiomyoma, are the most common benign neoplasm in the female genital tract and originate from the myometrium (smooth muscle.)[1,2] The cause of the fibroids is unknown, but however, it is estimated to be caused by estrogens and progesterone which proliferate tumor growth.[3,4] Fibroids are seen to rarely occur before menarche and reduce after menopause. They may be single or multiple and have a negative impact on the reproductive system, and are capable of causing severe morbidity among the women with deterioration of quality of life.}, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2020, title = {Fluoride-induced expression of neuroinflammatory markers and neurophysiological regulation in the brain of wistar rat model}, author = {Yugandhar P. Reddy and Santosh Tiwari and Lomas K. Tomar and Nalini Desai and Varun Kumar Sharma}, url = {https://link.springer.com/article/10.1007/s12011-020-02362-x}, doi = {10.1007/s12011-020-02362-x}, issn = {0163-4984}, year = {2020}, date = {2020-08-31}, urldate = {2020-08-01}, journal = {Biological Trace Element Research}, volume = {199}, issue = {7}, pages = {2621-2626}, publisher = {Springer Science and Business Media LLC}, abstract = {Excess fluoride intake has been linked with various pathological conditions. The objective of the present study was to understand the role of fluoride in neurotoxic, neuroinflammatory, and neurodegenerative changes in the brain tissue of Wistar rats. Wistar rats were fed with water containing 20–100 ppm (ppm) sodium fluoride (NaF). An array of neurotransmitters (acetylcholine, dopamine, epinephrine, norepinephrine, serotonin, histamine, and glutamate) expression levels were estimated with respect to different fluoride concentrations. Additionally, its effect on the expression levels of specific neuroinflammatory markers (iNOS, COX-2, TNF-α, PKC, VEGF, and HSP-70) in brain tissues of Wister rats was assessed. An increase in NaF concentration resulted in increased fluoride deposition in the brain which in turn caused increase levels of epinephrine, histamine, serotonin, and glutamate and decreased levels of norepinephrine, acetylcholine, and dopamine in a dose-dependent manner. Tissue fluoride levels of the hippocampus, neocortex, cerebellum, spinal cord, and sciatic nerve increased significantly in fluoride fed rats. Transmission electron microscopy in the experimental animals revealed axon deterioration, myelin sheath degeneration, and dark cells with scanty cytoplasm in the spinal cord and sciatic nerve. Additionally, vacuolated swollen mitochondria were observed in the neocortex, hippocampus, and cerebellum. Results suggest excess fluoride intake modulates a set of biological marker and promote neuroinflammatory and neurodegenerative condition in Wister rats. Therefore, we conclude that the accumulation of NaF alters the neurological function which leads to neurodegenerative disorders.}, key = {pmid32865723}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Chatur_2020, title = {Non obstructive hydrocolpos due to vesicovaginal reflux in an adolescent female}, author = {Chinky Chatur and Ankit Balani and R. Prabhakar Rao and Syed Althaf Ali and Anand Abkari}, url = {https://journals.lww.com/ijon/fulltext/2020/30050/non_obstructive_hydrocolpos_due_to_vesicovaginal.13.aspx}, doi = {10.4103/ijn.IJN_413_19}, issn = {0971-4065}, year = {2020}, date = {2020-08-28}, urldate = {2020-01-01}, journal = {Indian Journal of Nephrology}, volume = {30}, issue = {5}, pages = {348-349}, publisher = {Medknow}, key = {pmid33707826}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Musa_2020, title = {Asymptomatic presentation of a congenital malformation of the portal vein with portosystemic shunt}, author = {Juna Musa and Kulsum Madani and Kristi Saliaj and Jason Cai and Ali Guy and Blerina Saraci and Erisa Kola and Elton Ceka}, url = {https://www.sciencedirect.com/science/article/pii/S1930043320303848?via%3Dihub}, doi = {10.1016/j.radcr.2020.07.076}, issn = {1930-0433}, year = {2020}, date = {2020-08-24}, urldate = {2020-10-01}, journal = {Radiology Case Reports}, volume = {15}, issue = {10}, pages = {2009-2014}, publisher = {Elsevier BV}, abstract = {Malformations of the portal venous system consist of congenital and acquired anomalies. Congenital portosystemic shunts represent rare vascular developmental anomalies that allow partial or complete diversion of blood flow from the portal venous system to the systemic venous system, bypassing the liver. Congenital portosystemic shunts may be associated with malformations or congenital absence of the portal vein, and it was first described by John Abernethy in 1793. Most cases are diagnosed in early childhood, but some congenital shunts may remain asymptomatic and are encountered incidentally because of the widespread use of computed tomography and magnetic resonance imaging. In this report, we discuss the case of a 40-year-old female who presented to the Emergency Department with right upper quadrant pain, nausea, and vomiting. Clinical presentation and abdominal computed tomography angiography were consistent with the diagnosis of calculous cholecystitis and congenital absence of portal vein with intrahepatic portosystemic shunts. We discuss the importance of radiology in diagnosing such incidental malformations, coupled with a review of the current literature on this topic.}, key = {pmid32874401}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Gul_2020, title = {Molecular biomarkers in multiple sclerosis and its related disorders: a critical review}, author = {Maryam Gul and Amirhossein Azari Jafari and Muffaqam Shah and Seyyed Mohammad Sadeq Mirmoeeni and Safee Ullah Haider and Sadia Moinuddin and Ammar Chaudhry}, url = {https://www.mdpi.com/1422-0067/21/17/6020}, doi = {10.3390/ijms21176020}, issn = {1422-0067}, year = {2020}, date = {2020-08-21}, urldate = {2020-08-01}, journal = {International Journal of Molecular Sciences}, volume = {21}, issue = {17}, pages = {1-22}, publisher = {MDPI AG}, abstract = {Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) which can lead to severe disability. Several diseases can mimic the clinical manifestations of MS. This can often lead to a prolonged period that involves numerous tests and investigations before a definitive diagnosis is reached. As well as the possibility of misdiagnosis. Molecular biomarkers can play a unique role in this regard. Molecular biomarkers offer a unique view into the CNS disorders. They help us understand the pathophysiology of disease as well as guiding our diagnostic, therapeutic, and prognostic approaches in CNS disorders. This review highlights the most prominent molecular biomarkers found in the literature with respect to MS and its related disorders. Based on numerous recent clinical and experimental studies, we demonstrate that several molecular biomarkers could very well aid us in differentiating MS from its related disorders. The implications of this work will hopefully serve clinicians and researchers alike, who regularly deal with MS and its related disorders.}, key = {pmid32825639}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2020, title = {A rare case of hydranencephaly: A case report}, author = {Zafar Sultana Abdul Saleem and Vanacharala Anantha Kumari and Habib Khan Gulab Khan Pathan}, url = {https://www.ijmhr.org/IntJAnatRes/IJAR.2020.152}, doi = {10.16965/ijar.2020.152}, issn = {2321-4281}, year = {2020}, date = {2020-08-10}, urldate = {2020-08-10}, journal = {International Journal of Anatomy and Research}, volume = {8}, issue = {3}, pages = {7644-7648}, publisher = {IMED Research Publications}, keywords = {Anatomy, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Tahseen_2020, title = {Fetal outcomes of pregnancies in women at the extremes of maternal age}, author = {Surayya Tahseen and Syeda Maliha Fathima and Sowmya Sri Kondeti and Nabeeha Mujtaba Ali and Fatima Tahniyath}, url = {https://storage.googleapis.com/innctech/ejbps/article_issue/volume_7_july_issue_7/1593508177.pdf}, issn = {2349-8870}, year = {2020}, date = {2020-07-31}, urldate = {2020-07-31}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {7}, issue = {7}, pages = {450-456}, abstract = {Background: Extremes of maternal age adversely affect pregnancy outcomes.Teenage pregnancy is regarded as a serious public health problem and often occurs in the context of poor social support and maternal well-being. Teenage pregnancy is known to be associated with adverse pregnancy outcomes such as preterm births, low birth weight deliveries and increased risk of caesarean delivery. Methods: A hospital based prospective study carried out in the Department of Obstetrics and Gynaecology from October 2013 to September 2015 at Owaisi hospital and research centre and Princess Esra Hospital, a tertiary care centre, Deccan College of medical sciences, Hyderabad. Results: Among 8640 antenatal patients who delivered during the 24 months period i.e October 2013 to September 2015 at the hospital out of these 241(2.8%) were teenage primigravida aged 15 to 19 yrs. Conclusions: In India, 10.3% of the female population belongs to the age group of l5-19 years.[19] In 1997, the age specific fertility rate was found to be 52.5 live births per 1000 rural women aged between 15-19 years.[42] Over the years, there has not been much improvement in the country’s scenario as reported by the National Family Health Surveys. }, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2020, title = {Prevalence, risk factors and clinical profile of patients with cardioembolic stroke in South India: a five-year prospective study}, author = {Sandhya Manorenj and Sudhakar Barla and Srikant Jawalkar}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/6337/4100}, doi = {10.18203/2394-6040.ijcmph20203002}, issn = {2394-6032}, year = {2020}, date = {2020-07-26}, urldate = {2020-07-26}, journal = {International Journal of Community Medicine and Public Health}, volume = {7}, issue = {7}, pages = {2708-2714}, abstract = {Background:Stroke is the second leading cause of mortality and morbidity worldwide. Cardioembolic stroke accounts for 15-30% of Ischemic stroke. There have been very few clinical studies on cardioembolic stroke, especially from India. Our aim was to provide a demographic, risk factor and clinical profileof patients with cardioembolic stroke in South India.Methods:A prospective study was conducted at the Neurology Inpatient Department over a period of 5 years from January 2013 to January 2018 collecting necessary information and data from all cases diagnosed as cardioembolic stroke.Results:651 patients were diagnosed to have acute Ischemic stroke. Of the 76 patients (11.6%) diagnosed with cardioembolic stroke, 35 (46%) were females. Mean age was 53.5±12.2 years. Occurrence of cardioembolic stroke wasseen to be higher (71% vs 28.9%, pvalue<0.0001) in patients of older age group (46 years or more). A significant proportion of patients of the older age group (37%) had hypertension (pvalue=0.0048). Coronary artery disease (CAD) was the most prevalent cardiac disorder, observed in 42 patients (55.2%),valvular heart disease in 22 patients (28.9%) and atrial fibrillation in 14 patients (18.4%). Limb weakness (84.2%) and Middle Cerebral Artery (MCA) territory (73.6%) infarct were observed in majority of the patients.Conclusions:Prevalence of cardioembolic stroke in this region is lower than reported worldwide. While male predominance of cardioembolic stroke was noted, old age and hypertension were the major vascular risk factors identified. CAD was the major source of cardioembolism.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2020b, title = {Bacteriological profile and antibiotic sensitivity pattern of bacterial pathogens isolated from pus samples}, author = {Qursheed Sultana and Ajaz Hussain and Maimoona Mustafa and Mohammed Abdur Rab Ansari}, url = {https://www.ijcmas.com/9-7-2020/Qursheed%20Sultana,%20et%20al.pdf}, doi = {10.20546/ijcmas.2020.907.013}, issn = {2319-7692}, year = {2020}, date = {2020-07-10}, urldate = {2020-07-10}, journal = {International Journal of Current Microbiology and Applied Sciences }, volume = {9}, issue = {7}, pages = {114-122}, abstract = {Bacterial infections are considered as the common causes for the pyogenic infections. Various studies have shown that there is an inconsistency in bacteriological profile of the isolates and antibiotic resistance pattern. This demands for the periodic monitoring of the bacterial isolates and their antimicrobial sensitivity pattern. The present study aims to analyze the bacterial pathogens isolated from the pus samples and their antibiotic susceptibility pattern. This is a prospective, observational, single-centered study, conducted in a tertiary care hospital in Hyderabad for a period of 2 years, from August 2016 to 2018.A total of 410 pus samples were brought to the Microbiology lab from different inpatient and outpatient departments and were processed to identify the pathogens and their anti-microbial sensitivity pattern using Kirby Bauer disc diffusion method. The data analyzed was presented in percentages. Out of 410 samples analyzed, 257 (62.68%) were found to be culture positive. Among 257 culture positive isolates, 56.78% were gram negative bacteria and the rest 43.16% were gram positive bacteria. However, the most commonly isolated pathogens were Staphylococcus aureus followed by Klebsiella and E. coli. The gram positive bacteria were found to be most susceptible to vancomycin and linezolid, whereas gram negative isolates were most susceptible to imipenem, meropenem and colistin. The most common pathogen identified was Staphylococcus aureus. However, gram negative bacteria were predominant. The emerging bacterial resistance for various antimicrobial agents complicates the management of pyogenic infection. Periodic susceptibility data from various studies helps clinicians to select proper antibiotic for the isolates, thus preventing the emergence of the drug resistance stains.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Kerstgens_2020, title = {IRIDIUM Trial. Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study}, author = {A. M. Kerstgens and Jorge Maspero and Kenneth R. Chapman and Richard N. van Zyl-Smit and Ashfaq Hasan and Syed Mahmood Ahmed and Fahad Abdullah Bin Breik}, url = {https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30190-9/fulltext}, doi = {10.1016/S2213-2600(20)30190-9}, issn = {2213-2600}, year = {2020}, date = {2020-07-09}, urldate = {2020-07-09}, journal = {Lancet Respiratory Medicine}, volume = {8}, issue = {10}, pages = {1000-1012}, abstract = {Background: Patients with asthma who are inadequately controlled on inhaled corticosteroid–long-acting β2-adrenoceptor agonist (ICS–LABA) combinations might benefit from the addition of a long-acting muscarinic receptor antagonist. The aim of the IRIDIUM study was to assess the efficacy and safety of a once-daily, single-inhaler combination of mometasone furoate, indacaterol acetate, and glycopyrronium bromide (MF–IND–GLY) versus ICS–LABA in patients with inadequately controlled asthma. Methods: In this 52-week, double-blind, double-dummy, parallel-group, active-controlled phase 3 study, patients were recruited from 415 sites across 41 countries. Patients aged 18 to 75 years with symptomatic asthma despite treatment with medium-dose or high-dose ICS–LABA, at least one exacerbation in the previous year, and a percentage of predicted FEV1 of less than 80% were included. Enrolled patients were randomly assigned (1:1:1:1:1) via interactive response technology to receive medium-dose or high-dose MF–IND–GLY (80 μg, 150 μg, 50 μg; 160 μg, 150 μg, 50 μg) or MF–IND (160 μg, 150 μg; 320 μg, 150 μg) once daily via Breezhaler, or high-dose fluticasone–salmeterol (FLU–SAL; 500 μg, 50 μg) twice daily via Diskus. The primary outcome was change from baseline in trough FEV1 with MF–IND–GLY versus MF–IND at week 26 in patients in the full analysis set, analysed by means of a mixed model for repeated measures. Safety was assessed in all patients who received at least one dose of study drug. This study is registered with ClinicalTrials.gov, NCT02571777, and is completed. Findings: Between Dec 8, 2015, and Jun 14, 2019, 3092 of 4851 patients screened were randomly assigned (medium-dose MF–IND–GLY, n=620; high-dose MF–IND–GLY, n=619; medium-dose MF–IND, n=617; high-dose MF–IND, n=618; high-dose FLU–SAL, n=618). 2747 (88·8%) patients completed the 52-week treatment and 321 (10·4%) started but discontinued study treatment prematurely. Medium-dose MF–IND–GLY (treatment difference [Δ] 76 mL [95% CI 41–111]; p<0·001) and high-dose MF–IND–GLY (Δ 65 mL [31–99]; p<0·001) showed superior improvement in trough FEV1 versus corresponding doses of MF–IND at week 26. Improvements in trough FEV1 were greater for both medium-dose MF–IND–GLY (99 mL [64–133]; p<0·001) and high-dose MF–IND–GLY (119 mL [85–154]; p<0·001) than for high-dose FLU–SAL at week 26. Overall, the incidence of adverse events was balanced across the treatment groups. Seven deaths were reported (one with medium-dose MF–IND–GLY, two with high-dose MF–IND–GLY, and four with high-dose MF–IND) during the study; none of these deaths was considered by the investigators to be caused by study drugs or other study-related factors. Interpretation: Once-daily, single-inhaler MF–IND–GLY improved lung function versus ICS–LABA combinations (MF–IND and FLU–SAL) in patients with inadequately controlled asthma. The safety profile was similar across treatment groups. MF–IND–GLY therefore constitutes a good treatment option in these patients.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Fong_2021, title = {Sex disparities in cardiovascular disease outcomes among geriatric patients with prediabetes}, author = {Hee Kong Fong and Rupak Desai and Mohammed Faisaluddin and Tarang Parekh and Ahmed Mahmood and Vraj Shah and Priyal Shah and Vaishnavi Reddy Varakantam and Falah Abu Hassan and Sejal Savani and Rajkumar Doshi and Kishorbhai Gangani}, url = {https://www.primary-care-diabetes.com/article/S1751-9918(20)30217-5/fulltext}, doi = {10.1016/j.pcd.2020.06.005}, issn = {1751-9918}, year = {2020}, date = {2020-07-03}, urldate = {2021-02-01}, journal = {Primary Care Diabetes}, volume = {15}, issue = {1}, pages = {95-100}, publisher = {Elsevier BV}, abstract = {Aims: To analyze the sex-based differences in the prevalence of cardiovascular disease risk factors and outcomes in older patients with prediabetes using demographically matched national cohorts of hospitalized patients aged ≥65 years. Methods: We queried the 2007–2014 National Inpatient Database to identify older patients (>65 years) admitted with prediabetes using ICD-9 Clinical Modification codes. The older patients were then subcategorized based on sex. Comparative analyses of their baseline characteristics, the prevalence of cardiovascular(CV) disease comorbidities, hospitalization outcomes, and mortality rates were performed on propensity-matched cohorts for demographics. Results: A total of 1,197,978 older patients with prediabetes (599,223 males; mean age 75years and 598,755 females; mean age 76years) were identified. Higher admission rates were found commonly among older white males (84.1%) and females (81.7%). Prediabetic older males showed a higher frequency of cardiovascular comorbidities compared to females. Prediabetic older males had higher all-cause in-hospital mortality (4.2% vs. 3.6%, p < 0.001), acute myocardial infarction (7.0% vs. 4.7%, p < 0.001), arrhythmia (36.3% vs. 30.5%, p < 0.001), stroke (4.8% vs. 4.6%, p < 0.001), venous thromboembolism (3.3% vs. 3.0%, p < 0.001) and percutaneous coronary intervention (3.1% vs. 1.5%, p < 0.001) compared to females. Conclusions: Our analysis revealed that among older patients hospitalized with prediabetes, males suffered worse in-hospital CV outcomes and survival rates compared to females.}, key = {pmid32631808}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2020, title = {Effect of tea and coffee consumption on the blood pressure, pulse wave velocity and aortic pressures in young healthy individuals}, author = {Farah Fatima and Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Syed Abdul Tahreem}, url = {https://amphysiol.com/index.php/amp/article/view/v4i1.94611}, doi = {10.23921/amp.2020v4i1.94611}, issn = {2456-8422}, year = {2020}, date = {2020-06-30}, urldate = {2020-06-30}, journal = {Annals of Medical Physiology}, volume = {4}, issue = {1}, pages = {3-11}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, abstract = {Caffeine present in tea and coffee, the most commonly used beverages, has been implicated to have long term effects on cardiovascular system. The aim of this study was to document the acute and chronic effects of tea and coffee consumption on blood pressure, pulse wave velocity and aortic pressures in young, healthy individuals. This observational study was conducted on 86 healthy MBBS student volunteers of both genders between the age group of 18-27 years. Cardiovascular parameters (heart rate, peripheral blood pressure, central blood pressure, pulse wave velocity, augmentation pressure) were measured using PeriScope™. Participants were divided into 3 groups based on their history of consuming tea/coffee/both/none. Data collected was analyzed using SPSS 17.0. ANOVA or Welsh test of equality of means was used for knowing the differences for scale variables. Paired sample t test was used to know the acute effect of coffee consumption among group 1 participants in a before-after design. In regular tea consumers, the bilateral brachial SBP, DBP and MAP were significantly higher than individuals who did not consume tea regularly; similar results in these parameters were also observed in regular coffee drinkers. However the lower limb arterial parameters were not markedly differently in tea/coffee group compared to non-drinkers. In both tea and coffee group, AoSP and AoDP were significantly higher than non-drinkers. Additionally, coffee drinking has acute stimulatory effects on CVS as evident by increase in peripheral and central vascular parameters.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2020, title = {SARS-CoV-2 and ACE2 nexus}, author = {Mehnaaz Sameera Arifuddin}, url = {https://amphysiol.com/index.php/amp/article/view/v4i1.120578}, doi = {10.23921/amp.2020v4i1.120578}, issn = {2456-8422}, year = {2020}, date = {2020-06-30}, urldate = {2020-06-30}, journal = {Annals of Medical Physiology}, volume = {4}, issue = {1}, pages = {1-2}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Yusra_2020, title = {A study of serum high sensitive c-reactive protein and serum homocysteine levels in young adults with acute ischemic stroke}, author = {Fatima Yusra and Shafiqur Rehman Mohammed and Mohammed Zoheb}, url = {https://njmr.in/index.php/file/article/view/61/56}, issn = {2277-8810}, year = {2020}, date = {2020-06-30}, urldate = {2020-06-30}, journal = {National Journal of Medical Research}, volume = {10}, issue = {2}, pages = {80-84}, abstract = {Background: High sensitivity C-reactive protein (hsCRP) and homocysteine are considered important markers for cardiovascular and cerebrovascular diseases. Many studies have shown that high hsCRP and homocysteine levels are risk factors for ischemic stroke. Objective: Our objective is to investigate hsCRP and homocysteine levels in blood in young (49 years or below) and older (over 49 years) adults with ischemic stroke in a tertiary care hospital. Material and Methods: We retrospectively studied forty acute ischemic stroke patients admitted at Owaisi Hospital and Research Centre, Hyderabad, for six months (June 2019 to December 2019). Patients were divided into younger and older adults and all underwent tests as per standard protocol for stroke. Results: HsCRP level was elevated in 20 of 24 older stroke patients and in all young stroke patients (p<0.05). The mean hsCRP was significantly high in stroke patients overall (11.7mg/L).Fasting serum homocysteine level was elevated in 12 patients, mean value in them being 31.54 mg/dl and the difference was insignificant between younger and older patients. Conclusions: Elevated hsCRP, fasting homocysteine levels are strongly associated with acute ischemic stroke. A higher proportion of young stroke patients are found to have elevated hsCRP levels compared to older adults, while there is no significant difference in fasting homocysteine levels between the same.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Khajjayam_2020, title = {Clinical study of common bile duct stones with reference to surgical management}, author = {Radha Krishna Khajjayam and Apoorva Vempati and Syed Mujtaba Ibrahim}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/clinical-study-of-common-bile-duct-stones-with-reference-to-surgical-management_June_2020_1591091194_1608592.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-06-30}, urldate = {2020-06-30}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {6}, pages = {75-78}, abstract = {Background: Common bile duct stones (CBDS) occur in 8%-20% of patients suffering from gallstones. There is controversy regarding the management of CBDS due to availability of variety of therapeutic procedures each one having different advantages and limitations. Materials and methods: A prospective study was conducted from September 2013 to November 2015 in patients diagnosed to have choledocholithiasis. Results: Abdominal pain was the most common presenting symptom. Raised serum bilirubin and alkaline phosphatase was the most common biochemical abnormality. Out of 30 patients who underwent common bile duct (CBD) exploration 17 patients underwent T-tube drainage and 13 patients underwent choledochoduodenostomy (CDD).The CDD group had a signicantly lesser hospital stay when compared to T-tube group. Conclusion: In this era of endoscopy, surgery still has a role in the management of choledocholithiasis when ERCP fails. Surgical exploration achieves high success rates and is associated with acceptable morbidity. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @book{Khaleel_2020, title = {Handbook on Novel Coronavirus: What You Need to Know?}, author = {Mohammed Khaleel}, url = {https://www.ipinnovative.com/books-details/132-NDM1NzE0Mjg1NzE=}, isbn = {9789388022491}, year = {2020}, date = {2020-06-30}, booktitle = {Handbook on Novel Coronavirus: What You Need to Know?}, publisher = {IP Innovative Publication Pvt. Ltd.}, address = {New Delhi}, edition = {1st}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {book} } @article{Nizamuddin_2020, title = { CT scan vs MRI in diagnosing laryngeal carcinoma}, author = {Mohammed Nizamuddin and Mohammed Naseeruddin and Anand Abkari}, url = {https://aijournals.com/index.php/ajmrr/article/view/1536/1122}, doi = {10.47009/ajmrr.2020.8.1.11}, issn = {2347-3371}, year = {2020}, date = {2020-06-24}, urldate = {2020-06-24}, journal = {Asian Journal of Medical Radiological Research}, volume = {8}, issue = {1}, pages = {54-57}, abstract = {Background: MRI imaging offers more sensitivity than CT to cartilage invasion but results in a high rate of false-positive studies which decreases their overall accuracy. The objective is to compare accuracy of CT scan vs MRI in the laryngeal carcinoma. Subjects and Methods: All patients have been diagnosed, with and without contrast, including neck MRI and CT. In order to prevent invalidation, before laryngeal biopsy, MRI and CT scanning have been done such that the images are not altered by peri tumorous inflammation. Results: The MRI classification was right for 20 out of 25 patients (80 percent) and 5 outsized cases: three cT1b lesions were pT1a and two cT1a lesions were squamous cell papillomas during pathological examination. CT was accurately identified in 17 out of 25 patients (68%), with 8 understated cases: 3 cT1a lesions by CT were pT1b, 3 cT1a lesions were pT3, and 2 tumours had not been found in the CT scan. Conclusion: Our research showed that MRI in preoperative stage early glottic cancer is more sensitive than CT to accurately select eligible patients for conservatory larynx surgery like super cricoid laryngectomy and cordectomy.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Afreen_2020, title = {Role of platelet parameters in acute coronary syndrome}, author = {Sobia Afreen and Nabila Afsar and Idrees Akhtar Afroze}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-platelet-parameters-in-acute-coronary-syndrome_June_2020_1591092901_1816382.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-06-01}, urldate = {2020-06-01}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {6}, pages = {59-61}, abstract = {ACS is a set of signs and symptoms due to rupture of a plaque which is a consequence of platelet rich coronary thrombus formation. Thrombus leads to partial or complete coronary artery occlusion which inturn leads to myocardial ischemia and various clinical manifestation ranging from UA to acute myocardial infarction. Conventional risk factors include smoking, diabetes mellitus, hyperlipidemia, obesity and stress which either act singly or in combination increase the chances of developing coronary atherosclerosis.4 Platelet indices also vary in diseases like diabetes, hypertension, obesity, hyperlipidemia etc.,5 This study aims to study the role of platelet parameters in patients with acute coronary syndrome and those who are at higher risk in comparison with healthy individuals. Conclusion: These larger platelets can be easily identified during routine hematological analysis. For this purpose, we think that MPV measurement, in which is a non-invasive and easily available test, it may be an important tool predicting an impending acute coronary event and helping in early intervention to manage such patients. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Jahangir_2020b, title = {A study to assess the use of tranexamic acid intraoperative & post cesarean section to reduce blood loss}, author = { Juveria Jahangir and Fatima Zahra Shaik Mohd}, url = {https://ijogr.org/archive/volume/7/issue/1/article/13154#article}, doi = {10.18231/j.ijogr.2020.009}, issn = {2394-2754}, year = {2020}, date = {2020-05-28}, journal = {Indian Journal of Obstetrics and Gynecology Research}, volume = {7}, issue = {1}, pages = {42–45}, publisher = {IP Innovative Publication Pvt Ltd}, abstract = {Introduction: The connection between cesarean bleeding is comprehended both during and after C. section. The post-partum bleeding remains the principle reason of maternal complications. This investigation was directed to assess the impact and wellbeing of tranexamic acid to de crease cesarean blood loss (LSCS) and any reactions. Materials and Methods: Normal 100 women planned cesarean were analyzed somewhere in the range of 37 and 40 weeks. They were partitioned into two groups. The main group 50 individuals received 1 gm IV of tranexamic acid before 15 min of caesarean and the control set of 50 individuals didn’t get tranexamic acid. Results: The patient age, tallness, weight, gestational age in the two gatherings were comparative, measurably same. Haemoglobin fell marginally after labour in the two gatherings, however no measurable distinction between the two gatherings was watched. There were no thrombosis events in the investigation. Tranexamic acid drops the blood loss from the minute the placenta was conveyed to 2 hours after labour (P <0.001) and from the finish of the LSCS to 2 hours after labour (P <0.001). Conclusion: Tranexamic acid assumes a powerful job in diminishing blood loss during LSCS without making an unfavourable response. Hence, it tends to be utilized viably to diminish maternal bleeding during LSCS.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2020c, title = {Iatrogenic physeal plate injuries and its sequelae}, author = {Mohammed Jalal Mohiuddin and Mohammed Siddique Mohiuddin and C. Rahul Reddy}, url = {https://www.ijmsir.com/asset/images/uploads/15866649853598.pdf}, issn = {2458-868X}, year = {2020}, date = {2020-04-30}, urldate = {2020-04-30}, journal = {International Journal of Medical Science and Innovative Research}, volume = {5}, issue = {2}, pages = {66-69}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020d, title = {A reflection on HIV/AIDS research}, author = {M. V. Raghavendra Rao and Dilip Mathai and Tiara Calvo Leon and Mohammed Khaleel and Abrar A. Khan and Badam Aruna Kumari and Mahendra Kumar Verma}, url = {http://journalcmpr.com/sites/default/files/issue-files/2118-A-2020.pdf}, doi = {10.24327/23956429.ijcmpr202004870}, issn = {2395-6429}, year = {2020}, date = {2020-04-28}, urldate = {2020-04-28}, journal = {International Journal of Current Medical and Pharmaceutical Research}, volume = {6}, issue = {04(A)}, pages = {5084-5091}, abstract = {Acquired immune deficiency syndrome is a disease caused by immune deficiency virus.HIV spread through certain body fluids that attack the body's immune system, specifically CD4 cells, often called T cells. Over time HIV can destroy so many of these cells that the body can't fight off infections and disease. these special cells help the immune system fight off infections. Untreated, HIV reduces the number of CD4 cells (T cells) in the body. This damage to the immune system makes it harder and harder for the body to fight off infections and some other diseases. Opportunistic infections or cancers take advantage of a very weak immune system and signal that the person has AIDS. The disease was first brought to the attention of the general medical community in June 1981, when the centers for Disease Control and prevention five California men with severe immunodeficiency in the morbidity and mortality weekly report. The HIV infections leads to compromise immune system and patients become more vulnerable for many other infections as well. There has been nearly 30 years for the discovery of HIV and associated immune disease ie AIDS and very little therapeutics is available to combat AIDS In fact, it is very difficult to diagnose HIV infection as it remain dormant stage inside immune cell and our available diagnostic methods are ineffective to diagnose in early days of infection.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020e, title = {Prevalence and risk factors for hospital-acquired infections “clean care is safer care"}, author = {M. V. Raghavendra Rao and Abrar A. Khan and Dilip Mathai and Ramanaiah C. J. and Tiara Calvo Leon and Mohammed Khaleel and Pamphil Igman and Badam Aruna Kumari and Mohammed Ismail Nizami and Mahendra Kumar Verma}, url = {http://recentscientific.com/sites/default/files/16142-A-2020.pdf}, doi = {10.24327/ijrsr.2020.1104.5227 }, issn = {0976-3031}, year = {2020}, date = {2020-04-28}, urldate = {2020-04-28}, journal = {International Journal of Recent Scientific Research}, volume = {11}, issue = {04(A)}, pages = {38021-38028}, abstract = {Hospital acquired infections commonly known as nosocomial infections, is defined as medical related issues that are not associated with the patient’s original diagnosis on admission into the hospital, they typically surface 72 hours after the patient has been admitted in the hospital for treatment. These infections are usually bacteria but may also be viruses, fungi or parasites. Patients in hospitals have been found to be more susceptible to infections and may even die as a consequence of nosocomial infections. Cross transmission of microorganisms by the hands of healthcare personnel from ward-based computers at the patients’ bedside, might introduce an additional risk for critically ill patients, considering the frequent contact with nurses and other healthcare workers. Several reports have also demonstrated contamination of a wide variety of environmental sites including stethoscopes, blood-pressure cuffs, thermometers, bedrails, doors, furniture surfaces and other medical equipment with the potential to spread nosocomial infections. The most common pathogens implicated in nosocomial infections are gram-negative rods, mainly Escherichia coli, pseudomonas, enterobacter and gram-positive cocci such as enterococcus and staphylococcus aureas. MRSA and vancomycin-resistant enterococcus that are multidrug-resistant organisms are increasing in frequency and more difficult to treat. A study suggested that ward-based computers pose a low risk for cross-infection problems. Two other investigations conducted within a burns unit and an intensive care unit respectively described the presence of acinetobacter baumannii and methicillin-resistant staphylococcus aureaus (MRSA) on computer keyboards. It has been shown that nosocomial infections or hospital acquired infections are recurrent problems, identified chiefly in intensive care facilities, surgical, and medical wards. In Trinidad and Tobago information on nosocomial infections are lacking. Within the period 1992-1995, 7,158 nosocomial infections were documented from 72,532 patients (10.0/100 admissions). In Europe, incidences vary from 1% for all types of nosocomial infections and up to 23.6% in pediatric intensive care units. In the United States of America, the centre for disease control and prevention calculated approximately 1.7 million nosocomial infections from all types of microorganisms resulting in 99,000 deaths annually. }, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Ziauddin_2020, title = {A rare case of acrodermatitis enteropathica in a one year old child}, author = {Nilofer Ziauddin and Nayeem Sadath Haneef and Nikhat}, url = {https://www.jemds.com/data_pdf/nilofer%20ziauddin-i-apr-27-CR-.pdf}, doi = {10.14260/jemds/2020/318}, issn = {2278-4748}, year = {2020}, date = {2020-04-27}, urldate = {2020-04-27}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {9}, issue = {17}, pages = {1459-1463}, abstract = {Not available}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Sadaf_2020, title = {Correlation of systolic and diastolic time intervals with demographic and anthropometric parameters in young adults}, author = {Sadiqua Sadaf and Mehnaaz Sameera Arifuddin and Mohammed Ziya Rahman and Mohammed Abdul Hannan Hazari and Syeda Bushra Quadri}, url = {https://www.j-pcs.org/article.asp?issn=2395-5414;year=2020;volume=6;issue=1;spage=23;epage=32;aulast=Sadaf;t=6}, doi = {10.4103/jpcs.jpcs_56_19}, issn = {2395-5414}, year = {2020}, date = {2020-04-17}, urldate = {2020-04-17}, journal = {Journal of the Practice of Cardiovascular Sciences}, volume = {6}, issue = {1}, pages = {23-32}, publisher = {Wolters Kluwer - Medknow}, abstract = {Context: Dimensions of vasculature may vary with height, weight, and build of the individual. This may, in turn, influence the time intervals during cardiac cycle. Aims: The aim of this study was to correlate the systolic and diastolic time (DT) intervals (preejection period [PEP], ejection time [ET], upstroke time [UT], DT, pulse duration [PD], and ejection slope [ES]) of pulse waves recorded from all four limbs in relation to age, gender, weight, height, heart rate, and blood pressure and to compare these cardiac time intervals between individuals with or without parental history of hypertension. Settings and Design: Ninety-eight healthy MBBS students in the age group of 19–21 years were included. Subjects and Methods: Students' history and demographic data were noted. Anthropometric measurements were recorded. The measurement of peripheral arterial pressures (in all four limbs) and determination of cardiac intervals (PEP, ET, UT, DT, PD, and ES) was done by PeriScope™. Statistical Analysis Used: Data were analyzed using SPSS version 17.0. Results: Independent sample t-test showed statistically significant differences between genders with weight, height, waist circumference, and waist–hip ratio. Statistically significant differences existed between right arm systolic blood pressure, left arm systolic blood pressure, and left arm pulse pressure among males and females. Significant differences among males and females were observed in some of the cardiac time intervals. Mean arterial blood pressure recorded in all four limbs showed a significant negative correlation with right arm ES in males and left arm ES in females. Conclusion: Since gender, anthropometric parameters, and blood pressure influence cardiac time intervals, these should be adjusted for when deriving inference on left ventricular performance.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2020, title = {Comparison of safety and efficacy of pethidine and tramadol in shivering patients for surgeries under regional anesthesia}, author = {Syed Asrar Hussain and U. Jayashree and Atif Mohammed}, url = {http://iaimjournal.com/wp-content/uploads/2020/03/iaim_2020_0703_11.pdf}, issn = {2394-0026}, year = {2020}, date = {2020-03-31}, urldate = {2020-03-31}, journal = {International Archives of Integrated Medicine}, volume = {7}, issue = {3}, pages = {74-79}, abstract = {Background: Post-operative shivering is common complication of the regional anesthesia. This study was mainly undertaken to compare the efficacy of pethidine and tramadol in controlling the post-operative shivering.Materials and methods: A randomized controlled study was conducted among 80 patients undergoing different surgeries. All the patients were assessed for shivering grades, its disappearance, hemodynamic status and complications if any. Sedation scores were recorded and shivering scores were also recorded.Results: There was no statistically significant difference in the age, weight, sex and ASA grades between the tramadol and pethidine groups. All the hemodynamic responses were same in both the groups. The shivering stopped at an earlier point of time in tramadol group when compared to the pethidine group which was statistically significant. Sedation characteristics are significant at 5 minutes and 10 minutes for pethidine. Pethidine causes more sedation tramadol at 5 and 10 minutes.Conclusion: Tramadol was shown to be superior in efficacy when compared with the pethidine.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Jayashree_2020b, title = {A prospective randomized double blind controlled clinical study comparing epidural butorphanol versus nalbuphine as adjuvants in abdominal hysterectomy}, author = {U. Jayashree and Syed Asrar Hussain and Henna}, url = {http://iaimjournal.com/wp-content/uploads/2020/03/iaim_2020_0703_12.pdf}, issn = {2394-0026}, year = {2020}, date = {2020-03-31}, urldate = {2020-03-31}, journal = {International Archives of Integrated Medicine}, volume = {7}, issue = {3}, pages = {80-87}, abstract = {Background: Pain is abnoxius stimulus after surgery. This study was undertaken to evaluate the post-operative analgesic benefits in patients administered with epidural butorphanol and nalbuphine as adjuvants with local anesthetic post operatively for abdominal hysterectomy under epidural anaesthesia and to compare their post-operative efficacy.Material and methods: An RCT was conducted among 80 patients who were divided into two equal groups by computer generated random numbers. One group received Butorphanol and other received Nalbuphine. The sensory block, motor block, duration of analgesia, quality of analgesia and side effects were compared between the two groups.Results: There was no difference in the pulse rates of patients belonging to both the groups. Not much variation was recorded in systolic and diastolic blood pressures in both the groups. The mean onset of sensory block in Butorphanol group was 5.9 min and 4.6 min in Nalbuphine group. The mean pain score was 1.0 after three hours of injection in the butorphanol group and Nalbuphine group. The duration of analgesia was 7.85 hours in the Butorphanol and 7.88 hours in the Nalbuphine group. Nausea/ vomiting were the main complication among the Butorphanol group and also found in Nalbuphine group. In butorphanol group, the quality of analgesia was good in 93.3% and in Nalbuphine group in 90.0% of the cases. Conclusion: Both butorphanol and Nalbuphine had comparable efficacy and side effects as adjuvants in epidural anesthesia.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2020c, title = {A case report of aneurysmal bone cyst proximal tibia treated with intra-lesional curettage and bone graft cement}, author = {Mazharuddin Ali Khan and Mohammed Amanul Haq Qureshi and Shaik Vazeer Uddin}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/a-case-report-of-aneurysmal-bone-cyst-proximal-tibia-treated-with-intraandamp-ndash-lesional-curettage-and-bone-graft-cement_March_2020_1582979287_5207453.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2020}, date = {2020-03-31}, urldate = {2020-03-31}, journal = {International Journal of Scientific Research}, volume = {9}, issue = {3}, pages = {30-32}, abstract = {Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several sponge-like blood or serum lled, generally non-endothelialized spaces of various diameters.[1].The term is a misnomer, as the lesion is neither an aneurysm nor a cyst.[1]. Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population more often in females (2:1), usually before the age of 20 years, and most commonly in long bones metaphysis origin that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature due to translocation t(16;17)(q22;p13) leading to juxtaposition of promoter region CDH11 on 16q22, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as “uid-uid levels,” Currently, the standard of care and most widely employed treatment is intralesional curettage and bone grafting. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Banu_2020, title = {A rare case of herpes zoster ophthalmicus secondary to methotrexate induced immunosuppression}, author = {Ayesha Banu and Nayeem Sadath Haneef and Nikhat }, url = {https://www.jemds.com/data_pdf/ayesha%20banu-vinuthamar-30--CR-.pdf}, doi = {10.14260/jemds/2020/238}, issn = {2278-4748}, year = {2020}, date = {2020-03-30}, urldate = {2020-03-30}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {9}, issue = {13}, pages = {1106-1109}, abstract = {Not available}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020f, title = {The values and vision of artificial intelligence}, author = {M. V. Raghavendra Rao and Abrar A. Khan and Mohammed Khaleel and Khizer Hussain Junaidy and Amreen and Mahendra Kumar Verma and Dorababu P. and Dilip Mathai}, url = {https://journalijcar.org/sites/default/files/issue-files/10706-A-2020.pdf}, doi = {10.24327/ijcar.2020.21669.4264}, issn = {2319-6475}, year = {2020}, date = {2020-03-28}, urldate = {2020-03-28}, journal = {International Journal of Current Advanced Research}, volume = {9}, issue = {03(D)}, pages = {21664-21669}, abstract = {Artificial intelligence (AI), sometimes called machine intelligence, is intelligence demonstrated by machines, in contrast to the natural intelligence displayed by humans and animals. Recently AI techniques have sent vast waves across healthcare, even fueling an active discussion of whether AI doctors will eventually replace human physicians in the future. We believe that human physicians will not be replaced by machines in the foreseeable future, but AI can definitely assist physicians to make better clinical decisions or even replace human judgement in certain functional areas of healthcare (eg, radiology). Artificial intelligence (AI) has been developing rapidly in recent years in terms of software algorithms, hardware implementation, and applications in a vast number of areas. Artificial intelligence (AI) is being used or trialed for a variety of healthcare and research purposes, including detection of disease, management of chronic conditions, delivery of health services, and drug discovery. data-heavy nature makes it an ideal candidate for the application of AI across multiple disciplines, from diagnosis and pathology to drug discovery and epidemiology. It is foreseeable that together with reliable data management platforms AI methods will enable effective analysis of massive infectious disease and surveillance data to support risk and resource analysis for government agencies, healthcare service providers, and medical professionals in the future.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Jayashree_2020, title = {A comparative study to evaluate the efficacy of intranasal dexmedetomidine versus intranasal midazolam as pre medications in children}, author = {U. Jayashree and Syed Asrar Hussain and Humaira}, url = {http://iaimjournal.com/wp-content/uploads/2020/02/iaim_2020_0702_16.pdf}, issn = {2394-0026}, year = {2020}, date = {2020-02-29}, urldate = {2020-02-29}, journal = {International Archives of Integrated Medicine}, volume = {7}, issue = {2}, pages = {94-100}, abstract = {Background: Pediatric surgery amounts for enormous stress due to anesthesia and surgery for the children. This study was mainly undertaken to assess the efficacy and safety of Midazolam and dexmedetomidine as premedicants in children.Material and methods: A randomized controlled trial was undertaken in 100 children belonging toASA Grades I and II posted for surgery in a Institute of Medical sciences hospital were dividedequally in to two groups. One group received Dexmedetomidine and other received Midazolam. A baseline heart rate, respiratory rate, systolic blood pressure and activity of the child were noted in the pre-operative room. The premedicant was administered and after 30 minutes, a standard general anesthesia procedure was administered. Results: About 36.7% of children in Dexmedetomidine group and 10% in Midazolam group had their eyes closed but verbally arousable, 33.3% of dexmedetomidine and 40% of the Midazolam group had their eyes closed but arousable with light physical stimulation. About 43.3% of the Dexmedetomidine group children and 46.7% of the Midazolam children had moderate fear of mask, co-operative reassurance and 36.7% of the children in Dexmedetomidine group and 30% in Midazolam group were combative, crying.Conclusion: Dexmedetomidine was shown to be effective than Midazolam in Parental separation, pre induction and sedation.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Syeda_2020, title = {Evaluations of antidepressant activity of punica granatum peel extract in albino mice}, author = {Shakira Fathima Syeda and Sam Pavan Kumar G. and Mohammed Mohsin}, url = {https://www.ijbcp.com/index.php/ijbcp/article/view/3887/2804}, doi = {10.18203/2319-2003.ijbcp20200720 }, issn = {2279-0780}, year = {2020}, date = {2020-02-25}, urldate = {2020-02-25}, journal = {International Journal of Basic & Clinical Pharmacology}, volume = {9}, issue = {3}, pages = {449-453}, abstract = {Background: Depression is the most common disorder of mental illnesses and affects excess of 10-15% of population. According to the WHO reports, more than 350 million persons suffer from depression all over the world. The aim of present study is to evaluate anti-depressant activity of Punica granatum peel extract (PgPE) in albino mice. Methods: Male albino mice (20-30 g) were used. Animals were divided into 5 groups with 6 animals in each which were subjected to forced swim test. Group 1 is control, group 2 received (standard) imipramine 10 mg/kg, p.o, group 3 (T1) PgPE 50 mg/kg, p.o, group 4 (T2) PgPE 100 mg/kg, p.o, group 5 (T3) PgPE 200 mg/kg, at first animals were forced to swim for 15 min (trained), and the study was performed after 24 hrs. All the animals were treated with individual drug 60 min prior to study, animals were forced to swim for 6 min and the duration of immobility was recorded. The mouse was considered immobile when it floats motionlessly or made only those moments necessary to keep its head above the water surface. The total duration of immobility of each mouse was recorded after the test in each group. Results: The duration of immobility is significantly reduced at PgPE 200 mg/kg and results were analysed by one way analysis of variance (ANOVA). Conclusions: PgPE 200 mg/kg significantly (p<0.05) decreases the duration of immobility in mice.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Jahangir_2020, title = {Sublingual misoprostol versus dinoprostone gel in labour induction}, author = { Juveria Jahangir and Fatima Zahra Shaik Mohd}, url = {https://journal.barpetaogs.co.in/abstract/06127}, doi = {10.21276/obgyn.2020.6.2.13}, issn = {2454-2342}, year = {2020}, date = {2020-02-01}, urldate = {2020-02-01}, journal = {The New Indian Journal of OBGYN}, volume = {6}, issue = {2}, pages = {127–130}, publisher = {Marwah Infotech}, abstract = {Objective: This study was carried out to compare the outcome and safety of intravaginal misoprostol (PGE1) and intra-cervical dinoprostone gel (PGE 2) in induction of labour. Methods: In this study, 100 women between 19 and 30 years of age with a single live fetus, cephalic presentation and full-term pregnancy were included for induction of labour. Fifty women received 50 micrograms of Misoprostol intravaginal (study group) and 50 women received 0.5 mg of intracervical dinoprostone gel (control group). The comparison were made on the average time taken for the start of labour, the induction time at birth, the average duration of delivery, the need for oxytocin, the method of delivery. Results: The average time taken for the onset of labour was lower in the misoprostol group than in the dinoprostone group (40.30 min v/s 1 hour and 35 minutes). Similarly, the induction phase to the active phase (1 hour and 44 min v/s 4 hours and 25 min) and the active phase at the time of administration to delivery ( 3 hours 00 min v / s 4 hours 48 min) was lower for the misoprostol group. The rate of caesarean section was lower in the misoprostol group (6% v / s 26%). Maternal side effects were negligible in both groups and the neonatal outcome was good in both groups. The cost of induction was much lower in the misoprostol group. Conclusion: Misoprostol is a safe, effective and economical drug, suitable for the mother and the fetus for the induction of labour.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Kolli_2020, title = {Cutaneous sarcoidosis with concomitant pulmonary tuberculosis}, author = {Deepti Kolli and Nayeem Sadath Haneef and Nikhat Fatima and B. Y. Praveen Kumar }, url = {https://www.ejmanager.com/mnstemps/154/154-1573410787.pdf?t=1698477846}, doi = {10.5455/jmas.73123}, issn = {2231-1696}, year = {2020}, date = {2020-01-31}, urldate = {2020-01-01}, journal = {Journal of Medical and Allied Sciences}, volume = {10}, issue = {1}, pages = {33-36}, publisher = {ScopeMed}, abstract = {Sarcoidosis is a systemic disease of unknown etiology. It is characterized by the formation in all or several affected organs of epitheliod cell tubercles without caseation. Lupus pernio is a cutaneous manifestation of sarcoidosis. Tuberculosis is an important differential diagnosis for sarcoidosis and they closely resemble each other. We are reporting a rare case with classical features of lupus pernio who had concomitant pulmonary tuberculosis. Our patient presented with erythematous, indurated, plaques with scaling on the malar area of the face, cheeks and ear lobules which was consistent with lupus pernio both clinically and histologically. There was a history of weight loss (around 15%) and lethargy since 8 years, which coincided with onset of lesions. He developed high grade fever with sweating at night which lasted for more than 2 months and cough with expectoration. Chest examination revealed bilateral basal crepitations and Mantoux test was positive and broncho alveolar lavage showed acid fast bacilli. The patient was treated with anti-tubercular treatment followed by oral prednisolone over 3 months. Cutaneous lesions were treated with topical mild potency steroid along with intralesional triamcinolone. The overall response of the patient to treatment was satisfactory.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020b, title = {Prevailing and crop up technologies for the diagnosis of microbial infections}, author = {M. V. Raghavendra Rao and Dilip Mathai and Mohammed Khaleel and Khizer Hussain Junaidy and S. P. Pallavi and Jathavthu Madhavi}, url = {http://journalcmpr.com/sites/default/files/issue-files/2038-A-2020.pdf}, doi = {10.24327/23956429.ijcmpr202001821}, issn = {2395-6429}, year = {2020}, date = {2020-01-28}, urldate = {2020-01-28}, journal = {International Journal of Current Medical and Pharmaceutical Research}, volume = {6}, issue = {01(A)}, pages = {4866-4872}, abstract = {There are almost as many ways to look at the world of infectious disease as there are infectious agents. India is a densely populated tropical country with burden of very high. infectious diseases. Cultures and serological assays are usually used for microbial identification in infectious diseases. However culturing and isolation of fastidious pathogens which are not always available can be difficult and may take weeks or months to yield results. On the other hand, culture alone can't distinguish colonization from tissue invasion. Serological tests can be difficult to interpret in the setting of immunosuppression or when only a single sample is available for evaluation.Hence the pivotal role of molecular diagnosis is indispensible in Evidenced-based Laboratory Medicine.The panel-based molecular diagnostics for the rapid detection of pathogens have resulted in thinking about something changes completely in clinical microbiology and clinical practice. These Panel based tests are valid and reliable with rapid turnaround time and the detection of a large number of microorganisms and test interpretation. To observe fastidious organisms like Brucella, in sepsis/ PUO, in traditional blood cultures requires a longer time.CRP/PCT helps in presumptive but not in definitive diagnosis whereas in syndrome panel-based Microarray results can be obtained within an hour. These are fast and sensitive. The film Array blood culture identification panel (Biofire), the range now covers 4 major syndromes like respiratory infections including pneumonia, gastrointestinal infections, Meningitis/Encephalitis, and Septicemia. Sputum cultures are not very sensitive in molecular diagnostics in respiratory diseases and difficult to obtain samples in the pediatric population. Similarly, viral infections cannot be diagnosed using traditional methods. Histological examination, more sensitive, cannot identify the responsible fungi. The Galactomannan for fungal pneumonia needs to be done serially and prone to false-positive results. In order to deal with menace of drug-resistant bacteria, give effective treatment.LIPA (Line probe assay) molecular hybridization tool to diagnose non-tubercular mycobacterium, differentiation within MTB complex and drug susceptibility testing (Identification of resistance genes) India is a hot spot for the emergence of viral diseases. Nipah virus is a zoonotic virus and can be transmitted through contaminated food or directly between people. The molecular diagnosis helped to identify the pathogen. The new molecular test should provide reliable, cost-effective and timely results necessary for diagnosis and management. Test selection should not be based solely on cost. Performance characteristics and impact on patient care and management are critical components of the decision.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Wazir_2020, title = {An unusual case of alveolar rhabdomyosarcoma of the neck in an adult patient}, author = {Mohammed Wazir and Akriti G. Jain and Mohammed Faisaluddin and Daniel Tambunan }, url = {https://www.cureus.com/articles/21176-an-unusual-case-of-alveolar-rhabdomyosarcoma-of-the-neck-in-an-adult-patient#!/}, doi = {10.7759/cureus.6745}, issn = {2168-8184}, year = {2020}, date = {2020-01-22}, urldate = {2020-01-01}, journal = {Cureus}, volume = {12}, issue = {1}, pages = {e6745}, publisher = {Cureus, Inc.}, abstract = {Rhabdomyosarcoma is the most common soft tissue malignancy in adolescents. It is extremely rare for sarcomas to occur in patients more than 18 years of age. We present a case of rhabdomyosarcoma originating in skeletal muscles on the right side of the neck. Our case demonstrates the importance of considering an extensive differential diagnosis for a neck mass in adults. Our patient was diagnosed with alveolar variant of rhabdomyosarcoma and underwent chemotherapy and radiation therapy, but eventually due to recurrence opted for palliative therapy.}, key = {pmid32133267}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2020, title = {Role of neutrophil to lymphocyte ratio (NLR) In conjunction with coronary artery involvement as a biomarker for the magnitude of current of injury, type of intervention and clinical outcomes in STEMI}, author = {Mohammed Abdul Hannan Hazari and K. Laxman Rao and Bachi Tazneem and Sara Sana Ayesha Khanum and Huma Quadri and Syeda Kehkashan Jabeen}, url = {https://journalajcr.com/index.php/AJCR/article/view/22}, year = {2020}, date = {2020-01-17}, urldate = {2020-01-17}, journal = {Asian Journal of Cardiology Research}, volume = {3}, issue = {1}, pages = {1-7}, publisher = {OA Academic Press}, abstract = {Background: The potential prognostic biomarker—neutrophil to lymphocyte ratio (NLR) can be used to predict the severity of STEMI. We conducted an observational study using this parameter together with the extent of coronary artery involvement from coronary angiogram and magnitude of ST-elevation on ECG to determine the prognosis and the length of hospital stay. The effect of early reperfusion with thrombolysis was also observed. Methods and Results: 30 subjects (age 56.43 ± 13.98), with ST-elevation on ECG at admission, treated with streptokinase and undergoing angiogram were taken for the study. Repeated ECGs and complete blood picture on admission day, day 3, day of discharge and on the follow-up day were obtained. Out of 30 subjects, 15 received thrombolysis out of which 12 (80%) survived compared to the other 15 subjects who presented late, out of which 10 (66.6%) survived. Mean ST-elevation on the day of admission, on day 3, day of discharge and on follow up was found to be 0.39 ± 0.12, 0.18 ± 0.12, 0.05 ± 0.07, 0.00 ± 0.00 respectively. NLR values on admission day were 7.89 ± 4.98, day 3 (6.24 ± 5.05), day of discharge (4.34 ± 2.74) and on follow up (1.71 ± 1.40) indicating association of higher NLR values with magnitude of current of injury. NLR values as high as 18.5 were observed in expired subjects. The length of hospital stay was found to be 6.43 ± 5.03 days. Conclusion: There was a linear decrement in ST-segment resolution with a decrease in NLR and can be attributed to the natural course of disease and type of intervention provided. Nevertheless, the univariate correlation between ECG and NLR on various days of treatment was not significant.}, key = {AJCR.53641}, keywords = {Cardiology, Deccan School of Pharmacy, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2020, title = {Breaking the silence about the biofilm}, author = { M. V. Raghavendra Rao and Mohammed Khaleel and Manik Dass S. and Khizer Hussain Junaidy and Amreen and Mahendra Kumar Verma and Dilip Mathai }, url = {http://ierj.in/journal/index.php/ierj/article/view/1940/1953}, issn = {2454-9916}, year = {2020}, date = {2020-01-15}, urldate = {2020-01-15}, journal = {International Education and Research Journal}, volume = {6}, issue = {1}, pages = {25-29}, abstract = {Microorganism evolved with syntrophic consortium called as bio film which provides an beneficial environment for their growth.The biofilm formation is often considered as an adaptation of large number of microbes against unfavourable environmental conditions. However, there is prevailing scientific evidence suggesting role of biofilm in offering transport of essential molecules including nutrients.. Research findings have demonstrated that microbial cells are capable of producing variety of substances which serve as building blocks, for biofilm synthesis and cells get embedded into the matrix of extracellular polymeric substances (EPS). These multicellular microbial arrangements allow microbes to communicate within the local environment as well as the external environment. Certainly a biofilm promotes better growth and development of microbes. Also such arrangement provides microbes a protection against antibiotics and other antimicrobial agents. Microbes are capable to adhere with all microbial adherence to biotic material) a crucial step in microbial colonization is improved with biofilms, subsequently improving their growth. The research findings have demonstrated that microbes capable of Biofilm formation attach to various living tissues including external and visceral. The adherence allows host microbes interaction and pathogenecity as well. The capacity of microbial pathogenicity is function of expression of virulence factors and these virulence factors are directly linked with quorum sensing and biofilm formation}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Awasthi_2020, title = {Micronutrient-fortified infant cereal improves Hb status and reduces iron-deficiency anaemia in Indian infants: an effectiveness study}, author = {Shally Awasthi and Uppin Narayan Reddy and Monjori Mitra and Shweta Singh and Sanjeev Ganguly and Ivana Jankovic and Dominik Grathwohl and Colin I. Cercamondi and Apurba Ghosh}, url = {https://www.cambridge.org/core/services/aop-cambridge-core/content/view/54F0C227B9B2ADD0A752D3BF06B367AB/S0007114519003386a.pdf/micronutrient-fortified-infant-cereal-improves-hb-status-and-reduces-iron-deficiency-anaemia-in-indian-infants-an-effectiveness-study.pdf}, doi = {10.1017/s0007114519003386}, issn = {0007-1145}, year = {2020}, date = {2020-01-03}, urldate = {2020-01-01}, journal = {British Journal of Nutrition}, volume = {123}, issue = {7}, pages = {780-791}, publisher = {Cambridge University Press (CUP)}, abstract = {Anaemia affects approximately 69 % of Indian children aged 6–12 months, with Fe deficiency (ID) being a common cause. The effectiveness of micronutrient-fortified infant cereal in improving Fe status and neurodevelopment was evaluated in non-anaemic and mildly anaemic Indian infants. An intervention group (IC) enrolled at age 6 months consumed 50 g/d of rice-based cereal providing 3·75 mg Fe/d as ferrous fumarate for 6 months (n 80) and was compared with a matched static cross-sectional control group (CG) without intervention enrolled at age 12 months (n 80). Mean Hb was higher in IC (118·1 (sd 10·2) g/l) v. CG (109·5 (sd 16·4) g/l) at age 12 months (adjusted mean difference: 9·7 g/l; 95 % CI 5·1, 14·3; P < 0·001), while geometric mean serum ferritin tended to be higher (27·0 (–1 sd 13·4, +1 sd 54·4) v. 20·3 (–1 sd 7·5, +1 sd 55·0) ng/ml); P = 0·085) and soluble transferrin receptor was lower (1·70 (–1 sd 1·19, +1 sd 2·43) v. 2·07 (–1 sd 1·29, +1 sd 3·33) mg/l; P = 0·014). Anaemia (23 v. 45 %; P = 0·007) and ID (17 v. 40 %; P = 0·003) were lower in IC v. CG. Bayley Scales of Infant and Toddler Development Third Edition scores for language (P = 0·003), motor development (P = 0·018), social-emotional (P = 0·004) and adaptive behaviour (P < 0·001), but not cognitive development (P = 0·980), were higher in IC v. CG. No significant difference in anthropometric Z-scores was observed between the groups. Consuming a micronutrient-fortified infant cereal daily for 6 months during complementary feeding promoted better Fe status while reducing the risk for anaemia and ID and was associated with superior neurodevelopmental scores.}, key = {pmid31896356}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Maheen_2020, title = {Patterns and determinants of utilization of health care in urban field practice area of a tertiary care institute, Hyderabad}, author = {Moniza Maheen and Fawwad M. Shaikh and Vaseem Anjum and A. Chandrasekhar}, url = {https://ijphrd.com/scripts/IJPHRD%20January_2020_compressed.pdf}, doi = {10.37506/v11/i1/2020/ijphrd/193811}, issn = {0976-0245}, year = {2020}, date = {2020-01-01}, urldate = {2020-01-01}, journal = {Indian Journal of Public Health Research and Development }, volume = {11}, issue = {1}, pages = {194-197}, abstract = {Introduction: It is estimated that 68% of the World’s population shall live in urban areas by 2050; India will have added 416 million to the urban population. With rapid increase in population, the healthcare needs also increase. In 2016, 63% of the deaths were due to non-communicable diseases and 26% due to communicable diseases. India is a country with high level of morbidity. Communicable diseases contribute to the morbidity more than the non-communicable diseases. Despite the increasing public and private expenditure on healthcare, utilization of health services still remain low. The utilization of public health services in India range from 10-30%. Aim and Objective: To study the Patterns and Determinants of Utilization of Healthcare. Materials and Method: A cross-sectional study was conducted among 256 attendees of a health camp conducted in urban field practice area, using a predesigned and pretested questionnaire. Data entered into Microsoft excel and analysed using SPSS 20. Results: The overall population of the area was 7634, 2256 were attended the camp giving a 30% utilisation. Out of 256 patients 40.6% were males and 59.4% were females. 25.7% Respiratory, 12.9% musculoskeletal and 11.7% gastrointestinal problems were common. It was found that the behavioural determinants of subjects utilising healthcare facilities both in public and private sector showed that free services was observed as main factor for approaching public healthcare against reliability. Whereas less waiting time was the principal factor compared to cleanliness for visiting private healthcare. Conclusion: In the study population, Respiratory problems were found to be highest, private healthcare facility was preferred.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2019e, title = {Conflict of interest or competing interest: What is in the name?}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v3i4.94415}, doi = {10.23921/amp.2019v3i4.94415}, issn = {2456-8422}, year = {2019}, date = {2019-12-31}, urldate = {2019-12-31}, journal = {Annals of Medical Physiology}, volume = {3}, issue = {4}, pages = {29-30}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Nunavath_2019, title = {Hypocalcemic recurrent generalized seizures with bilateral basal ganglia and frontal calcification as the initial manifestation of Albright’s hereditary osteodystrophy in a child: a pictorial and video-graphic representations}, author = {Akhilesh Kumar Nunavath and Sandhya Manorenj and Srikant Jawalkar and Bushra Naaz}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935980/}, doi = {10.4103/jpn.JPN_86_19}, issn = {1817-1745}, year = {2019}, date = {2019-12-31}, urldate = {2019-12-31}, journal = {Journal of Pediatric Neurosciences}, volume = {14}, issue = {4}, pages = {232-235}, abstract = {Albright hereditary osteodystrophy (AHO) is a hereditary metabolic disorder that presents with seizure secondary to hypocalcaemia. A careful phenotypic assessment of patients presenting with seizure clues to the diagnosis of AHO. The characteristic features are short stature,obesity and brachydactyly. Pseudohypoparathyroidism (PHP) is observed in patients with AHO and is characterized by inability of the body to respond appropriately to parathormone, mainly characterized by hypocalcaemia, increased serum parathormone concentration, insensitivity to the biological activity of parathormone, and hyperphosphatemia. In this study, we report a 14-year-old boy with distinctive phenotype of AHO, oral manifestations, and signs of tetany with PHP presenting as recurrent generalized seizure.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Afsar_2019b, title = {Anemia: a diagnostic malady in management of dengue patients}, author = {Nabila Afsar and Sabahat Zamani Nagma and Idrees Akhtar Afroze}, url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2542/1793}, doi = {10.21276/APALM.2542}, issn = {2349-6983}, year = {2019}, date = {2019-12-28}, urldate = {2019-12-28}, journal = {Annals of Pathology and Laboratory Medicine}, volume = {6}, issue = {12}, pages = {A647-A652}, abstract = {Background: With the high prevalence of anemia and increasing incidence of dengue in developing countries like India, diagnosis of anemia in dengue patients needs to be stressed. There is higher hemoglobin and hematocrit as a result of plasma leakage in dengue; hence diagnosis and treatment of anemia may be missed. Methods: A retrospective study was done on 138 dengue patients diagnosed in 2017, in a tertiary care teaching hospital in Hyderabad. The complete blood counts and blood picture data was retrieved and statistical analysis was performed using Microsoft Excel. Result: 60% of patients >5 yrs of age showed low hemoglobin while 93.3% showed hypochromia. In patients aged 5-11yrs and 12-14 yrs, 31.4% and 14.3% respectively had low hemoglobin, but hypochromia was noted in 48.6% and 57.1% .In non pregnant females, 68.4% showed low hemoglobin while 55.3% showed hypochromia. In males, 25% showed low hemoglobin whereas 13.9% showed hypochromia. Wide variability in hemoglobin concentration of same patient was noted with coefficient of variation above 1% in 91.7% of cases. MCV and MCH had coefficient of variation more than 1.1% and 0.5% in 25% and 69.4% of cases respectively. Conclusion: Mean corpuscular volume is a stable parameter which can be used to assess the morphological status of the RBC even in a background of hemoconcentration where the hemoglobin is spuriously raised. The importance of inclusion of red cell indices especially mean corpuscular volume in complete blood counts reports is stressed.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2020b, title = {Limb length discrepancy (LLD) after lower limb long bone fractures in pediatric age group}, author = {Mohammed Jalal Mohiuddin and C. Rahul Reddy and Syed Abdul Raheem and Chavva Shamsunder and Thoom Shloka}, url = {https://www.orthopaper.com/archives/2020/vol6issue1/PartE/6-1-30-228.pdf}, doi = {10.22271/ortho.2020.v6.i1e.1873}, issn = {2395-1958}, year = {2019}, date = {2019-12-23}, urldate = {2019-12-23}, journal = {International Journal of Orthopaedics Sciences}, volume = {6}, issue = {1}, pages = {276-279}, abstract = {Background: It has been mentioned that Limb length discrepancy may vary with the age of child, position of fracture and the type of treatment done (ORIF- open reduction and internal fixation/CRIF-closed reduction and internal fixation/Conservative). This treatment methods influence the amount of overriding after reduction of fracture. Aims and Objectives: To determine the Limb Length Discrepancy (LLD) developing after lower limb long bone fractures in age group 2 years to 16 years. Methodology: They were 20 patients, with history of lower limb long bone fracture with minimal duration post fracture of 6 months. Subject particulars were recorded as per methodology protocol by two different observers. Results: The study group ranged from 3 years to 16 years with mean age of 8.5 years. There were eleven males and nine females. Seven out of twenty patients managed conservatively with plaster application and Open reduction and plating done for 8 patients. Remaining five patients were treated with closed reduction and fixation with either Titanium Elastic nails or external fixator. Post op X ray showed no overriding in eight patients and all were from the group managed by open reduction and plate fixation. Fractures managed by closed reduction found to have over riding which was less than 1 cm in four subjects and 1cm to 2cms in remaining five cases. LLD when measured, it ranged between -1cms to +3cms (mean +1 cm). Three post fracture limb has no Limb Length Discrepancy (LLD) at all. There was lengthening seen in rest of patients it was up to 1 cm in 10 and more than 1cm in five cases.2 patients out of 20 patients developed significant lengthening and presented with limp, so they underwent epiphysiodesis near skeletal maturity. Conclusion: There is need to educate parents and budding orthopedic surgeons regarding the importance of conservative management and acceptance of some degree of allowable mal-alignment. The fractures in pediatric age groups need to be followed till skeletal maturity as there is associated risk of developing LLD during the course of fracture union. This LLD sometime needs intervention in the form of timely epiphysiodesis at the time of near skeletal maturity. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2020, title = {CTEV- brief over view and short term follow up study}, author = {Mohammed Jalal Mohiuddin and J. Satyanarayana and Sai Rithvika and Syeda Hafsa Razvi and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2020/vol6issue1/PartE/6-1-29-263.pdf}, doi = {10.22271/ortho.2020.v6.i1e.1872}, issn = {2395-1958}, year = {2019}, date = {2019-12-20}, urldate = {2019-12-20}, journal = {International Journal of Orthopaedics Sciences}, volume = {6}, issue = {1}, pages = {271-275}, abstract = {Background: The plan of studying CTEV correction was proposed as it is one of the common congenital orthopedic deformity with various available mode of treatment. Among available treatment modalities it was found that Ponseti method of manipulation is least invasive, easy to learn and highly effective. Under this impression project was proposed to study its effectiveness. Aim: Aim of study was to evaluate the effectiveness of Ponseti technique of the plaster cast application in the management of CTEV. Objectives: The objectives were to compare the effected limb with the normal limb (in unilateral cases), evaluate the Achilles tendon function and morphology after percutaneous tenotomy clinically and sonologically and to assess the recurrences of deformities. Methodology: The study is Retrospective observational type of study carried out in the Department of Orthopedics with 20 patients diagnosed with CTEV (both unilateral and bilateral) who were treated at our centre from beginning. Pirani score at presentation was taken to quantify the severity of the deformity. The Ponseti Technique was used to correct this deformity. Percutaneous Tendo Achilles tenotomy was performed in those cases that had resistant equinus deformity. Dennis brown splint was offered to all the patients after complete correction. Ultrasound examination of the hip, vessels, Tendo Achilles was performed to check for underlying hip dysplasia, patency of vessels and for the continuity of Achilles tendon. The strength of the Peronei muscles was measured clinically. Result: It was found that out of 20 patients under study contributing 27 feet, 15 were males and 5 were females. There was bilateral presentation in 7 patients and remaining 13 has unilateral deformity which was on left side in 9 and right side in 4 patients. One patient presented with amniotic band syndrome with right sided CTEV. The average Pirani’s score was 3.74/6. 13 patients showed a Pirani score of 4.5. In patients of unilateral CTEV there was variation in the sizes of foot where the effected foot was smaller than that of the normal with a mean difference of 0.45cms. Great toe shortening was noticed in 17 patients with no significant limb length difference. Ultrasound screening of the hip showed that all the hips were mature and stable with alpha angle being greater than 60 degrees. Ultrasound for the vascular status revealed no abnormality in the wave pattern of the vasculature of effected foot with the normal foot in unilateral cases. In the patient with congenital band syndrome, the peroneal artery was absent. The Tendo Achilles (TA) tendon regained continuity in all the patients that have undergone percutaneous TA tenotomy. Three patients showed recurrence of the deformity and all of them were found noncompliant with the Abduction Brace. These three patients needed surgery for the deformity that has recurred. One had under gone PMSTR; one need limited posterior release and one patient required Tibialis. Conclusion: The study was about necessity to diagnose this deformity as early as possible, preferably in antenatal scans. As it helps the patient to seek early intervention for its correction. There are many existing anatomical alterations these all need to be evaluated further in future and their impact on CTEV correction, its relapse and performance of foot in future. The compliance to the abduction brace after correction is most important factor to prevent development of the relapse. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Qureshi_2020, title = {Case series-spontaneous chronic tendo achilles (TA) rupture and management}, author = {Mohammed Amanul Haq Qureshi and Patlolla Karthik Reddy and Mohammed Jalal Mohiuddin}, url = {https://www.orthoresearchjournal.com/pdf/2020/vol4issue1/PartB/4-1-10-778.pdf}, doi = {10.33545/orthor.2020.v4.i1b.204}, issn = {2521-3466}, year = {2019}, date = {2019-12-12}, urldate = {2019-12-12}, journal = {National Journal of Clinical Orthopaedics}, volume = {4}, issue = {1}, pages = {90-92}, abstract = {Although being the strongest tendon in the body, the Achilles tendon is the most frequently ruptured tendon in the lower limb and comprises approximately 20% of all large tendon ruptures. The classical site of rupture is generally 3cm-6cm proximal to its insertion into the calcaneal tuberosity, as there is a hypo vascular zone present in this area of tendon. The most common mechanism usually involves eccentric loading on a dorsiflexed ankle with the knee extended (soleus and gastrocnemius on maximal stretch. A bilateral Tendo Achilles rupture is uncommon, and for it to occur spontaneously is notably rare (1%). Risk factors for spontaneous TA ruptures includes local Corticosteroid use Quinolone antibiotics (ciprofloxacin), previous tendon rupture, Systemic disease (like gout, hypothyroidism, diabetes, tuberculosis, gonorrhea, syphilis, systemic lupus erythematosus, rheumatoid arthritis), Ageing, Increased BMI and Primary Achilles tendon tumors etc. Described are the 10 feet (8 patients), two had bilateral presentation. All came after 3 weeks of injury and treated with debridement, V-Y plasty and FHL (flexor Hallucis Longus) transfer. All patients regained full movements at the ankle and resume their routine activities at 3 months follow-up.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Ibrahim_2020, title = {Evaluation of different methods of management in pseudocysts of pancreas}, author = {Syed Mujtaba Ibrahim and Atif Abdul Samee and Mohammed Abdul Hadi}, url = {https://www.casereportsofsurgery.com/article/12/2-1-4-971.pdf}, issn = {2708-1494}, year = {2019}, date = {2019-12-07}, urldate = {2019-12-07}, journal = {International Journal of Case Reports in Surgery}, volume = {2}, issue = {1}, pages = {06-08}, abstract = {Background: Pancreatic pseudocysts are the most common cystic lesions of the pancreas. Surgical drainage remains the principal method of treating pseudocysts; its pre-eminance has recently been challenged. The introduction of innovative procedures both by the interventional radiologists and therapeutic endoscopists offer the (attractive) ability to drain pancreatic fluid collections non-operatively. Aim: To study the various treatment modalities and overall morbidity and mortality of pancreatic pseudocysts. Methodology: It was a prospective observational study. A study of 20 cases of pseudocysts of pancreas, who were subjected to various procedures, has been carried out between September 2010 to August 2012 at Deccan College of Medical Sciences, Hyderabad. Results: It is predominantly a disease of the elderly men with male to female incidence ratio 4:1. The commonest cause of pseudocysts of the pancreas in this study is chronic pancreatitis with prevalence of 60%. The commonest presentation is upper abdominal pain with upper abdominal mass. Serum amylase levels are not much of value either in diagnosis or in follow-up treatment. The commonest site is lesser sac and common cause in this situation being chronic pancreatitis. In all the cases it was confirmed that the cysts wall is deficient of epithelium by HPE. Cystogastrostomy was the commonest procedure done and the results were very good. Infection was the commonest complication. Mortality was nil. Conclusion: To conclude the in the present study, it was observed that the commonest cause was chronic pancreatitis and the commonest procedure done with good post-operative results was cystogastrostomy.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Nayar_2019, title = {Management of community‐acquired bacterial pneumonia in adults: limitations of current antibiotics and future therapies}, author = {Sandeep Nayar and Ashfaq Hasan and Pradyut Waghray and Srinivasan Ramananthan and Jaishid Ahdal and Rishi Jain}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852216/pdf/LI-36-525.pdf}, doi = {10.4103/lungindia.lungindia_38_19}, issn = {0970-2113}, year = {2019}, date = {2019-12-01}, urldate = {2019-12-01}, journal = {Lung India}, volume = {36}, issue = {6}, pages = {525-533}, abstract = {Community‑acquired bacterial pneumonia (CABP) is one of the leading causes of morbidity and mortality in India and worldwide. Evidence indicates that Gram‑positive, Gram‑negative, and atypical bacteria are encountered with near‑equal frequency. Despite guideline recommendations and antibiotic options for the management of CABP, burden of morbidity and mortality is high, which is attributable to a variety of factors. Failure of empirical therapy, probably because of insufficient microbial coverage, increasing bacterial resistance, and adverse effects of existing treatments, underlies the unsuccessful treatment of CABP, especially in India. Multiple novel therapies that have entered clinical development phases have potential to address some of these issues. This article discusses the current treatment guidelines in CABP, management limitations, and emerging potential treatment options in the management of CABP.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Mohd_2019, title = {Three-dimensional miniplate: for the management of mandibular parasymphysis fractures}, author = {Yousuf Qureshi Mohd and Sreenatha Reddy and Ramen Sinha and Anmol Agarwal and Umayra Fatima and Mohammed Abidullah}, url = {https://journals.lww.com/aoms/fulltext/2019/09020/three_dimensional_miniplate__for_the_management_of.15.aspx}, doi = {10.4103/ams.ams_172_17}, issn = {2231-0746}, year = {2019}, date = {2019-12-01}, urldate = {2019-01-01}, journal = {Annals of Maxillofacial Surgery}, volume = {9}, issue = {2}, pages = {333-339}, publisher = {Medknow}, abstract = {Background: Recently, oral and maxillofacial surgeons are favoring three-dimensional (3D) miniplates to treat mandibular fractures. Aims: The aim of the study is to evaluate the efficacy of 3D-miniplates over standard miniplates in the management of mandibular parasymphysis fracture. Materials and Methods: Forty patients with mandibular parasymphysis fractures were divided into two groups of 20 patients each. Group I patients underwent osteosynthesis of mandibular fracture by noncompression, unicortical, and stainless steel 3D miniplates, and Group II patients underwent osteosynthesis by noncompression, unicortical, and stainless steel Champy's miniplates. All the patients were followed up 6 months’ postoperatively, evaluating occlusion, mobility of fracture segment, pain, wound dehiscence, neurological deficit, and infection. Statistical Analysis Used: The data were analyzed by SPSS for windows (version 17) statistical package (SPSS Inc., Chicago, IL, USA). Chi-square test was carried out to determine the statistical difference between the groups. Results: Mobility of the fractured site was evaluated postoperatively after 2 weeks, and it was found that mobility was absent in all the cases of Group I and 36 (80%) cases in Group II. There was significant difference in the mean visual analog scale scores among the Group I and II when compared from preoperative to 4-week follow-up. In Group II, two patients showed wound dehiscence. After 2 weeks, infection was seen in two patients of Group II. Conclusion: 3D plates in mandibular parasymphysis fractures give dimensional stability and carry low morbidity and infection rates.}, key = {pmid31909011}, keywords = {Dentistry}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2019b, title = {Sexual dimorphism in adult human mandible of South Indian origin}, author = {Zafar Sultana Abdul Saleem and Tallapanani Sreekanth and S. Niveditha}, url = {https://rfppl.co.in/view_abstract.php?jid=2&art_id=9792}, doi = {10.21088/ija.2320.0022.8419.6}, issn = {2320–0022}, year = {2019}, date = {2019-12-01}, urldate = {2019-12-01}, journal = {Indian Journal of Anatomy}, volume = {8}, issue = {4}, pages = {283-288}, publisher = {Red Flower Publication Private, Ltd.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @inbook{Hasan_2019, title = {History of TB: Robert Koch and Beyond}, author = {Ashfaq Hasan}, editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover}, url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_1}, doi = {10.1007/978-981-32-9413-4_1}, isbn = {9789813294134}, year = {2019}, date = {2019-12-01}, urldate = {2019-01-01}, booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions}, pages = {3-16}, publisher = {Springer Singapore}, chapter = {1}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {inbook} } @inbook{Hasan_2019b, title = {Clinical Aspects and Principles of Management of Tuberculosis}, author = {Ashfaq Hasan and Sai Haranath Praveen and Chandrakant Tarke and Fahad Abdullah Bin Breik}, editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover}, url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_20}, doi = {10.1007/978-981-32-9413-4_20}, isbn = {9789813294134}, year = {2019}, date = {2019-12-01}, urldate = {2019-01-01}, booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions}, pages = {355-374}, publisher = {Springer Singapore}, chapter = {20}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {inbook} } @article{Jabeen_2019, title = {An epidemiological study of ARI among under five attending urban health center of a medical college}, author = {Hafsa Jabeen and M. S. K. Swarupa and A. Chandrasekhar}, url = {https://ijphrd.com/scripts/IJPHRD%20December_2019_Combined.pdf}, doi = {10.37506/v10/i12/2019/ijphrd/191964}, issn = {0976-0245}, year = {2019}, date = {2019-12-01}, urldate = {2019-12-01}, journal = {Indian Journal of Public Health Research and Development }, volume = {10}, issue = {12}, pages = {305-309}, abstract = {Introduction: In India, an estimated 26 millions of children are born every year.1 As per Census 2011, the share of children (0-6 years) accounts 13% of the total population in the Country. An estimated 12.7 lakh children die every year before completing 5 years of age.1 15% of the mortality in them is due to Acute respiratory Infections (ARI). The occurrence of ARI is related to various risk factors in the child and in the environment. Many of these risk factors are amenable to corrective measures. Therefore, the present study undertook to identify the prevalence and various risk factors for acute respiratory tract infection in under-five children. Objectives: 1. To study the prevalence of ARI in under five children. 2. To study the risk factors associated with ARI. Method: A cross sectional facility based study in Urban health centre of Deccan college of Medical Sciences. All under five children attending health centre during the study period of 6 months (November 2017–April 2017). Results: The present study showed 56% of ARI prevalence. Majority (55.3%) of study subjects were females. More number of subjects(35.5%) belongs to 0-12 month age group. Least number of children belongs to 49-60 months age group. Majority (41.8%) of study population belongs to SES-III (according to Kuppuswamy classification). Only (47.7%) of the subjects were fully immunized. The present study revealed that there is statistically significant association between age, type of family, socioeconomic status, Mothers education, Vitamin-A supplementation, Over-crowding, presence of separate kitchen and Family h/o parental smoking p=<0.05 with occurrence of ARI. Conclusions: The present study found that age of the child, type of family, socioeconomic status, Mothers education, Vitamin-A supplementation, Over-crowding, presence of separate kitchen and Family h/o parental smoking were the significant risk factors responsible for ARI in under-five children.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khajjayam_2019, title = {Case of DU perforation with secondary omental necrosis- a rare case report}, author = {Radha Krishna Khajjayam and Bushra Khan and Atif Abdul Samee and Syed Mujtaba Ibrahim}, url = {https://www.ijmbs.info/index.php/ijmbs/article/view/757/624}, doi = {10.32553/ijmbs.v3i11.757}, issn = {2589-868X}, year = {2019}, date = {2019-11-30}, urldate = {2019-11-30}, journal = {International Journal of Medical and Biomedical Studies}, volume = {3}, issue = {11}, pages = {129-131}, abstract = {Introduction: The Omentum is rich in blood supply. Omental Infarction can be classified as primary or secondary depending on the pathogenesis. Aims and Objectives: To report a case of DU perforation with secondary Omental Infarction. Case Details: A 21 year old male patient came with complaints of generalized dull aching abdominal pain, associated with persistent vomiting and high grade fever since 3 days. On examination, he was drowsy, BP was not recordable and peripheral pulses were not palpable. Abdominal examination revealed guarding and rigidity. X-ray erect abdomen showed gas under the right dome of the diaphragm (pneumoperitoneum). The patient was taken up for an exploratory laparotomy. Intraoperatively, findings included: 1) A 0.5*0.5cm in size perforation over the anterior first part of the duodenum, 2) approximately 3L of haemorrhagic peritoneal fluid 3) necrosed omentum and 4) petechial patches over the parietal wall of peritoneum. Primary repair of the DU perforation with omental plug (modified graham’s repair) with omentectomy of the necrosed part of omentum was done. The HPE report of excised specimen of omentum was suggestive of intense congestion and necro-inflammatory reaction of the omentum with necrosis and netrophilic infiltrate. Conclusion: A rare case of DU perforation with secondary omental necrosis is being reported. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Patel_2019, title = {Community diagnosis by conducting family health survey in the field practice area of a medical college}, author = {Mizba Basheer Patel and Moniza Maheen and Fawwad M. Shaikh and A. Chandrasekhar}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/5506/3592}, doi = {10.18203/2394-6040.ijcmph20195468}, issn = {2394-6032}, year = {2019}, date = {2019-11-27}, urldate = {2019-11-27}, journal = {International Journal of Community Medicine and Public Health}, volume = {6}, issue = {12}, pages = {5191-5196}, abstract = {Background: In a developing country like India, with limited resources health needs of individuals and community are enormously increasing. Health related problems may be addressed amicably by community diagnosis. Assessment and prioritization of health issues followed by formulation of action plans with strategies and their implementation can be effectively achieved, by using family health surveys. Methods: Using family health survey 500 families, constituting 2640 individuals were studied. Their health status and socio-demographic details were taken. Households and families were selected randomly. Data entry and analysis was done by appropriate use of statistical tools. Results: Study showed 52.27% males and 47.73% females. Majority (51.5%) belonged to 16-45 years followed by 6-15 years of age (25%). Among 9.09% of the under-five, fully immunized were 90.4% and partially immunized were 9.6%. 6.06% were above 60 years. Nuclear families were 68%. Majority (36%) of the families belonged to socio-economic class II (modified B.G. Prasad classification). 10.6% were illiterate and 11.3% were below seven years of age. Overcrowding was present in 24% of the families. Common morbidities were hypertension (32.2%), diabetes (26.9%), respiratory diseases (19.2%) eye problems (6.2%) and skin diseases (3.8%). Geriatric problems were present in one out of four individuals. Conclusions: Family health survey can be used as an educational tool for undergraduate medical students to understand common morbidities and determinants of diseases in the community. Family health surveys are important for a community as necessary intervention can be done for illnesses and health-related problems.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ashok_2019, title = {Study on the incidence of occurrence of the ossification of superior transverse scapular ligament with its clinical implications}, author = {Panjala Ashok and Shiny Vinila B. H. }, url = {https://www.ijmhr.org/ijar.7.4/IJAR.2019.306.pdf}, doi = {10.16965/ijar.2019.306}, issn = {2321-4287}, year = {2019}, date = {2019-11-05}, urldate = {2019-11-05}, journal = {International Journal of Anatomy and Research}, volume = {7}, issue = {4.2}, pages = {7066-7069}, publisher = {I MED Research Publications}, abstract = {Introduction: Supra scapular notch is present on the superior border of the scapula. It gives passage to the suprascapular nerve. The supra scapular notch is bridged by the superior transverse scapular ligament and converted into supra scapular foramen. Ossification of this superior transverse scapular ligament may compress or entrap the suprascapular nerve which is passing through the foramen. The present study was undertaken to find out the incidence of occurrence of the ossification of superior transverse scapular ligament. Materials and methods: 89 scapulae were collected from the Department of Anatomy, Deccan College of Medical Sciences, Hyderabad. Damaged scapulae were excluded. All the scapulae were examined to note the incidence of occurrence of the ossification of the transverse scapular ligament and also any variations of it. Results: Out of 89 scapulae 15 scapulae of the scapulae were bearing ossified superior transverse scapular ligament in which 6 were of the right side and 6 were of the left side. Duplication of the superior transverse scapular ligament was observed in one left scapula. Incomplete ossification was observed in 2 scapulae 1 on the right and another on the left side. Conclusion: Based on the results of the present study, ossification of the transverse scapular ligament is not very rare in this populations group. So, the knowledge about the ossification of superior transverse scapular ligament and the risk of supra scapular nerve entrapment is very much essential for the physicians and the surgeons while dealing with these cases.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2019c, title = {A morphometric study of mandibular foramen in dry adult human mandibles of Indian population in Telangana State}, author = {Zafar Sultana Abdul Saleem and Tallapanani Sreekanth}, url = {https://www.ijmhr.org/IntJAnatRes/IJAR.2019.308}, doi = {10.16965/ijar.2019.308}, issn = {2321-4281}, year = {2019}, date = {2019-11-01}, urldate = {2019-11-01}, journal = {International Journal of Anatomy and Research}, volume = {7}, number = {2}, issue = {4}, pages = {7080-7085}, publisher = {IMED Research Publications}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Sameera_2019, title = {Morphometric analysis and sexual dimorphism of hyoid bone in Telangana population}, author = {Syeda Sadia Sameera and K. Ephraim Vikram Rao}, url = {https://www.ijmhr.org/IntJAnatRes/IJAR.2019.298}, doi = {10.16965/ijar.2019.298}, issn = {2321-4287}, year = {2019}, date = {2019-10-31}, urldate = {2019-10-01}, journal = {International Journal of Anatomy and Research}, volume = {7}, issue = {4.1}, pages = {7038–7041}, publisher = {I MED Research Publications}, abstract = {Introduction: Determination of sex is of crucial importance in forensic investigations, when only a part of the body or skeletal remains are available. The present study focussed on the sexual dimorphism of hyoid bone in Telangana population by using morphometric analysis. Materials and methods: The present study was carried out on a total of 60 hyoid bones in which 30 were of male and 30 were of female individuals. The bones were obtained from the department of Anatomy, Osmania Medical College and Deccan College of Medical Sciences, Hyderabad. Damaged and deformed bones were excluded, and only fully intact bones were included in the study. Lengths of greater horns, lengths of lesser horns, total hyoid length, and distance between distal ends of right and left greater horns, width of the body, length of the body and the thickness of the body of hyoid bone were measured by using sliding calipers. Results: All parameters showed significant difference between the male and female groups. The measurements of all the parameters were significantly higher in males than in females. Conclusion: All parameters used in the present study confirmed sexual dimorphism in hyoid bone. Hence, hyoid bone can be considered in forensic investigations or anthropological studies to determine the sex of an individual.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019g, title = {Variation in the size of foot and great toe in unilateral CTEV (club foot deformity)}, author = {Mohammed Jalal Mohiuddin and Syeda Sadia Sameera and Syeda Hafsa Razvi and Sai Rithvika}, url = {https://www.ijcap.org/journal-article-file/9896}, doi = {10.18231/j.ijcap.2019.066}, issn = {2394-2118}, year = {2019}, date = {2019-10-12}, urldate = {2019-10-12}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {6}, issue = {3}, pages = {299-303}, abstract = {Introduction: Congenital Talipes Equinovarus (CTEV) is one of the common foot deformities seen in new born. It has prevalence of 1 in 1000 population with male preponderance. There is lot of anatomical and functional differences between the effected foot and the normal foot. These differences include variation in size of foot, size of toes, altered vasculature of foot, muscle imbalance between the everters and invertors of foot. These differences can easily be made out if it’s a unilateral deformity as the control for comparison will be the normal foot. Materials and Methods: Present study was done at our institute with coordination with department of orthopedics, including 20 patients with unilateral CTEV. The size of the foot and toes measured after full correction of the deformity. Results: It was found that there is constant decrease in the size of effected foot which is obvious on measurement and there is considerable clinical shortening of the great toe in comparison with the second toe in Club feet. Conclusion: The results obtained in present study will help the orthopedic surgeon to look into the matter of size of foot in future as the child grows and its cosmetic and functional impact over the activity of the subject.}, keywords = {Anatomy, Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2019d, title = {Precision medicine in the era of live cell imaging}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v3i3.68136}, doi = {10.23921/amp.2019v3i3.68136}, issn = {2456-8422}, year = {2019}, date = {2019-10-03}, urldate = {2019-10-03}, journal = {Annals of Medical Physiology}, volume = {3}, issue = {3}, pages = {27-28}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Tiwari_2019, title = {Gene expression patterns of COX-1, COX-2 and iNOS in H. pylori infected histopathological conditions}, author = {Santosh K. Tiwari and Asma Sultana Shaik and Abjal Pasha Shaik and Abdullah A. Alyousef and Avinash Bardia and Md. Aejaz Habeeb and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0882401019308009?via%3Dihub}, doi = {10.1016/j.micpath.2019.103634}, issn = {0882-4010}, year = {2019}, date = {2019-10-01}, urldate = {2019-10-01}, journal = {Microbial Pathogenesis}, volume = {135}, pages = {103634}, publisher = {Elsevier BV}, abstract = {Background: Research indicates that Helicobacter pylori can inflict severe histological damage through the modulation of host-related genes. The current study investigated the effect of H. pylori genotypes in the outcome of disease, and the expression of anti-apoptotic related genes, COX-1, COX-2, and iNOS genes in benign, pre-malignant, and malignant lesions of gastric carcinogenesis. Materials and methods: Tissue samples from H. pylori positive patients were graded based on the genotype of the infected H. pylori strain. Expression of COX-1, COX-2 and iNOS was assessed using a combination of real-time PCR and immunohistochemistry. Results: Gene expression studies confirmed that COX-2 and iNOS expression was highly and selectively induced in epithelium with premalignant changes such as atrophic conditions, metaplasia and dysplasia, suggesting an important role of these genes in the sequence to gastric carcinoma of the intestinal type. Furthermore, the expression of COX-2 and iNOS was also dependent on the genotype of H. pylori and subjects with genotype-1 exhibited significantly higher expressions of COX-2 and iNOS compared to other genotypes. Comparison of the expression levels among infected and uninfected individuals demonstrated significant difference in the expression pattern of COX-2 gene whereas iNOS expression was found only in subjects infected H. pylori (p < 0.001). Immunohistochemical staining showed 1.5619 folds higher propensity of COX-2 and 3.2941 folds higher intensity of iNOS expression in subjects infected with H. pylori genotype 1. Conclusion: The up-regulation of COX-2 and iNOS was associated with the genotype of the H. pylori strain and the presence of certain genotype may greatly affect early events during carcinogenesis.}, key = {pmid31325568}, keywords = {Central Research Laboratory, Medical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2019, title = {Prevalence of auto-immune thyroid disease and anti-TPO antibodies in patients visiting out-patient ward for routine health check-up}, author = {Tahmeen Jameel and Mizba Khanam and Qursheed Sultana and Mohammed Ishaq}, year = {2019}, date = {2019-10-01}, urldate = {2019-10-01}, journal = {IOSR Journal of Biotechnology and Biochemistry}, volume = {5}, issue = {5}, pages = {39-41}, abstract = {The objective of the present study was to investigate prevalence of Auto-Immune Thyroid Disease (AITD) and screening for anti-thyroid peroxide auto antibodies (anti-TPO) in subjects visiting out-patient ward of Department of Medicine (Princess Esra Hospital, Hyderabad). A total of 136 cases were included consecutively. Age and gender of the patients were recorded and serum was tested for Thyroid Profile and anti-TPO antibodies by Enzyme Linked ImmunoSorbent Assay (ELISA). The male to female ratio in 136 cases was 6.4%:93.6%. It was observed that 36 cases (26%) were found to be suffering from thyroid disease based on TSH, T3 and T4 levels of these 16 (11.7%) were hypothyroid, 7 (5%) were hyperthyroid cases. The remaining 10 (7%) cases were identified as having subclinical hypothyroidism. Of these cases 34 were found to be positive for anti-TPO auto-antibodies. The 2 negative cases were of hypothyroidism. Inordinately high proportion of females were found among AITD cases as well as among all the 136 cases selected for the study.}, keywords = {Biochemistry, Central Research Laboratory, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Nagma_2019, title = { Mixed connective tissue disease highlighting diagnostic exigency and treatment woes}, author = {Sabahat Zamani Nagma and Nabila Afsar and Idrees Akhtar Afroze and Atiya Begum}, url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2468/1758}, doi = {10.21276/APALM.2468}, issn = {2349-6983}, year = {2019}, date = {2019-10-01}, urldate = {2019-10-01}, journal = {Annals of Pathology and Laboratory Medicine}, volume = {6}, issue = {9}, pages = {C97-C100}, abstract = {Mixed connective tissue disease (MCTD) is a rare connective tissue disease characterized by manifestations that overlap symptoms typical of several other inflammatory diseases of connective tissue. A presence of anti-ribonucleoprotein antibodies (antiU1RNP) in high titer is a typical immunological finding. A 20 year old female complained of chilling and cyanosis of fingers on cold exposure since 5 years, with pain and numbness, hardening of skin of both hands, episodes of Raynaud’s phenomenon,gangrenous changes, self amputation of distal digit of middle finger. Systemic manifestations were also associated. A 15 year old female complained of thickening and tightening of skin of face and hands since 5 months, associated with joint pains, shortness of breath, dysphagia and photosensitivity of skin. Both cases were positive for Anti U1-RNP and Anti-SSA/Ro52 antibodies. Serology, radiology and histopathology were performed. MCTD may be difficult to define as definite classification criteria are not fulfilled. Young and pediatric patients with skin manifestations must be investigated to initiate early treatment and monitor renal parameters. Patient compliance and trust in treating physician is a key to early diagnosis and treatment. Treating physician must recognize symptoms and refer patients to higher centres. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Faheem_2019, title = {Measurement of urea and creatinine as a marker of renal function in Type 2 diabetes mellitus in patients with good glycemic control and poor glycemic control}, author = {Raisa Faheem and Tahmeen Jameel and Raiyan Ali Afrooz and Syed Junaid Ahmed}, url = {https://saudijournals.com/media/articles/SIJB_29_234-236.pdf}, doi = {10.36348/SIJB.2019.v02i09.002 }, issn = {2616-8650}, year = {2019}, date = {2019-09-30}, urldate = {2019-09-30}, journal = {Scholars International Journal of Biochemistry}, volume = {2}, issue = {9}, pages = {234-236}, abstract = {Diabetes is a common cause of end stage renal disease and approximately 20 to 30% of all diabetics will develop nephropathy. Diabetic nephropathy is characterised by abnormal renal function with reduction of glomerular filtration and rise in the level of Serum Urea and Creatinine. The study was conducted at Princess Esra Hospital, Deccan College of Medical Sciences. Patients with Dm in the age group 35 Yrs – 55 Yrs and controls also of the same age group Glycosylated Haemoglobin (Hb A1C) was done to categorise patients into two groups. Patients with good glycemic control having HbA1c<6-7%, Studies have demonstrated that the complications of diabetes can be delayed or prevented if HbA1c can be kept between 6-7%. The other group of patients were having poor glycemic control with HbA1c above 8%. The following parameters were included in the study FBS, PLBS, HbA1cm Urea and Creatinine. These parameters were estimated in normal (controls) and diabetics (with good glycemic control) and diabetics (with poor glycemic control). It was found that the blood sugar, blood urea and serum creatinine levels were significantly higher in diabetic patients with poor glycemic control compared to diabetic patients with good glycemic control. Strong relationship of blood urea and serum creatinine levels was found with blood sugar and HbA1c levels. Blood urea, serum creatinine blood sugar along with HbA1c would be helpful to monitor the diabetes patients to assess renal function.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Kehkashan_2019, title = {Use of various contraceptive methods in postpartum women- a prospective study in South Indian women}, author = {Anjum Kehkashan and G. Divya Chowdary}, url = {https://www.medpulse.in/Gynacology/Article/Volume11Issue3/OBGY_11_3_2.pdf}, doi = {10.26611/10121132}, issn = {2579-0870}, year = {2019}, date = {2019-09-30}, urldate = {2019-09-30}, journal = {MedPulse – International Journal of Gynaecology}, volume = {11}, issue = {3}, pages = {87-95}, abstract = {Background: Although most women would want to wait for more than two years before having another baby, their fertility behaviours during the first year following birth may decrease or increase the length of the birth interval. The purpose of this study is: 1. To study the most preferred contraception out of various contraceptive methods by the postpartum women. 2. To study the failure rates in the chosen method of contraception by the postpartum women. 3. To study the side effects and complications of the method chosen by the postpartum women. Materials and Methods: This prospective study is carried out at a tertiary care Centre in the Department of Obstetrics and Gynaecology at Owaisi Hospital and Research Centre and Princess Esra Hospital affiliated by Deccan College of medical sciences, Hyderabad. The study population included 400 pregnant women attending ANC’s also attending Family planning counselling clinic for a period of 2 years. Results: Out of 5328 antenatal patients who delivered, patient counselling was given for Postpartum Contraception, 3826 (71%) women delivered at our hospital, Out of which 1566 (29%) requested for postpartum contraception and 400 (7.5%) of them were enrolled for our study considering inclusion and exclusion criteria. Conclusion: IUCD is the most preferred reversible postpartum contraceptive method among various contraceptive methods in postpartum women for birth spacing in our study. It is a long-acting reversible contraceptive (LARC) method which is safe, cheap and highly effective in preventing unintended pregnancy and spacing births than with other reversible methods - Oral contraceptive pills or Injection DMPA. Sterilization was the second common method preferred by postpartum women who completed their family. The complications and failure rates are very low. So, it is the best method to be preferred if the family is completed.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Jahangir_2019, title = {The study of single dose antibiotic in caesarean section}, author = {Juveria Jahangir and Fatima Zahra Shaik Mohd}, url = {https://ijogr.org/archive/volume/6/issue/3/article/13098#article}, doi = {10.18231/j.ijogr.2019.075}, issn = {2394-2754}, year = {2019}, date = {2019-09-28}, urldate = {2019-09-01}, journal = {Indian Journal of Obstetrics and Gynecology Research}, volume = {6}, issue = {3}, pages = {346–349}, publisher = {IP Innovative Publication Pvt Ltd}, abstract = {Introduction: Wound infection is a common problem in obstetric and surgical procedures. It is not clear whether perioperative prophylaxis of one portion of anti-infective agents is sufficient to prevent wound contamination. This test was aimed at assessing whether anti-infection of one perioperative part was successful in counteracting diseases after use in women undergoing caesarean section. Materials and Methods: This is a multicentre study. Participants were given a single dose of 1 g of cefotaxime intravenously before surgery, and the incidence of postoperative complications such as wound infections, wound resuturing, etc. was monitored. Results: The study included 100 elective caesarean sections. Cefotaxime injection of 1 g IV was injected 30 minutes before surgery. The incidence of febrile morbidity was seen in 10 %, and wound infection was in 5% of total patient. The microorganisms isolated from the wound infection were E. coli, Pseudomonas, which were sensitive to cefoperazone-sulbactum and linezolid. The average length of hospital stay was 4 days. Conclusion: A single prophylactic dose of cefotaxime is effective for the prevention of postoperative infection. The results obtained in this study shows that single-dose antibiotic prophylaxis is effective. The resistance of microorganisms can be prevented with this prophylactic single-dose antibiotic. This prospective study confirms that one-time antibiotic prophylaxis had a positive effect on women undergoing a planned caesarean section.}, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Marupaka_2019, title = {Avulsion fractures around the knee and their importance}, author = {Sravan Kumar Marupaka and Shweta Kataria and Ravikanth Jakkani and Jampala Venkateshwarlu and Chavva Shamsunder}, url = {https://www.ijcmsr.com/uploads/1/0/2/7/102704056/ijcmsr_312_v1.pdf}, doi = {10.21276/ijcmsr.2019.4.3.54}, issn = {2565-4802}, year = {2019}, date = {2019-09-21}, urldate = {2019-09-21}, journal = {International Journal of Contemporary Medicine Surgery and Radiology}, volume = {4}, issue = {3}, pages = {C241-C247}, abstract = {Introduction: Avulsion fracture involves pulling off of a bone fragment from the attachment site of a ligament, tendon or joint capsule. Our study evaluated MRI findings associated with avulsion fractures around the knee. Material and methods: This is a retrospective analytical study of avulsion fractures around the knee. This study has clearance from institutional review board. Informed consent was not needed. There are 62 MRI studies including 51 male and 11 female patients between 14 to 73 years of age. MRI studies of patients with avulsion fractures around the knee were analyzed for associated bone and soft tissue injuries. Results: PCL avulsions with 30 cases was the commonest avulsion around the knee in our study. ACL avulsion noted in 18 cases. Two patients had both cruciates avulsed. There was no statistically significant difference in the medial meniscal injuries between ACL and PCL avulsions with a P value of 0.49 (P < 0.05 is significant). Lateral meniscal injuries occurred in significantly larger proportion of ACL avulsions compared to PCL avulsions with a P value of 0.007 (P < 0.05 is significant). Conclusion: Significantly larger number of cases of lateral meniscal injuries was seen in ACL avulsions compared to that of PCL. Avulsion fractures are radiographically subtle but are associated with significant soft tissue and bone abnormalities.}, keywords = {Orthopedics, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Atharuddin_2019b, title = {A study on complications, surgical management & its outcome with varicose veins in lower limbs}, author = {Athar Mohammed Atharuddin and Atif Abdul Samee}, url = {https://www.surgeryscience.com/articles/254/3-4-62-417.pdf}, doi = {10.33545/surgery.2019.v3.i4e.254}, issn = {2616-3462}, year = {2019}, date = {2019-09-18}, urldate = {2019-09-18}, journal = {International Journal of Surgery Science}, volume = {3}, issue = {4}, pages = {275-278}, abstract = {Background: Varicose veins are a common clinical condition affecting the lower limbs. Usually patient comes for a cosmetic problem; it can cause complications giving rise to significant morbidity if not treated in time. Different options are available for surgical management. Aim & Objective: The present study mainly investigates the complications, surgical management and its outcome with varicose veins in lower limbs. Methodology: We include 80 patients over a two year period all admitted patients to a Princess Esra Hospital, Shahali Banda, Hyderabad and Owasi Hospital and Research Centre, Kanchan Bagh, Hyderabad from period June 2017-June 2019. Results: In the present study showed long saphenous system involvement in 72.5% of cases. Majority of patients in the present series were patients of CEAP class 2 and 3 class. Almost 73.75 % had combined saphenofemoral and perforator incompetence. In the present study, underwent duplex USG evaluation for confirmation of diagnosis. This investigation was required to accurately diagnose 18 cases of saphenofemoral incompetence, 10 cases of saphenopopliteal incompetence and 12 cases of perforator incompetence. Most of the patients had wound infections followed by hematoma and residual varicosity. Conclusion: From this study we conclude that commonest age group affected is 21-40 years. The involvement of long saphenous and communicating system is commonest followed by long saphenous involvement alone. Pain is the commonest symptom. Patients with involvement of longsaphenous and communicating system or long saphenous and short saphenous involvement were more symptomatic than the others. Commonest complication in post-operative treatment is wound infection. Complications of varicose veins responded well to operative treatment.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Khan_2019, title = {A prospective study on etiology and clinical features of varicose veins: a hospital based study}, author = {Saif Mohammed Khan and Saniya Ahmed}, url = {https://www.surgeryscience.com/articles/209/3-4-1-111.pdf}, doi = {10.33545/surgery.2019.v3.i4a.209}, issn = {2616-3462}, year = {2019}, date = {2019-09-17}, urldate = {2019-09-17}, journal = {Internationa3l Journal of Surgery Science}, volume = {3}, issue = {4}, pages = {06-10}, abstract = {Background: Varicose vein are abnormally dilated, tortuous, elongated veins of lower limbs which have permanently lost their valvular efficiency. The main objectives of our study was to study etiological profile (Age, sex, occupation and site pathology) and different modalities utilized in our institute and to assess and study final outcome in patients included in our study. Methodology: It was a prospective study; fifty cases of varicose veins were attending outpatient Department and admitted in the Surgical Department of Deccan Medical College & Hospital from October 2018 to September 2019. Results: In the present study, fifty cases of varicose veins treated in our institute form the basis of this study. The average age of the patients was 41.86 years. The youngest patient was of 19 years and the oldest was 65 years of age. Varicose veins were common in males; the male to female ratio was 3.1:1. The number of patients who were involved in occupations requiring prolonged hours of standing was 35 (70%). A positive family history of varicose veins was present in only 4 cases (8%). Deep vein thrombosis was present in 7 patients (12.72%). The commonest presentation was dilated veins. The common associated symptoms were itching and pigmentation in 27 patients (54%) and ulceration in 13 patients (26%). 5 patients had bilateral varicose veins and the remaining 45 had only one limb affected. The limb commonly affected was right lower extremity in 29 cases (52.7%). Long saphenous vein was involved in 42 limbs (76.36%) and both long and short saphenous vein were affected only in 3 limbs (5.4%). Conclusion: The database of our retrospective study regarding age & sex incidence, clinicopathological features and therapeutic outcome was comparable to other studies in various literatures. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Atharuddin_2019, title = {Study of prevalence, demographic & clinical manifestations of lower limb varicose veins}, author = {Athar Mohammed Atharuddin and Kondal Reddy J.}, url = {https://www.surgeryscience.com/articles/253/3-4-61-663.pdf}, doi = {10.33545/surgery.2019.v3.i4e.253}, issn = {2616-3462}, year = {2019}, date = {2019-09-15}, urldate = {2019-09-15}, journal = {International Journal of Surgery Science}, volume = {3}, issue = {4}, pages = {272-274}, abstract = {Background: Varicose veins are a common condition that the current paper elaborates the features of the condition in a local Indian population. Aim & Objective: The main aim of the present study to evaluate the prevalence, demographics and clinical manifestations of lower limb varicose veins patients. Methodology: We include 80 patients over a two year period all admitted patients to a Princess Esra Hospital, Shahali Banda, Hyderabad and Owasi Hospital and Research Centre, Kanchan Bagh, Hyderabad from period June 2017-June 2019. Results: In the present study, most of the patients (93.4%) were in the 20-50 years age group. Out of 80 patients, 70 patients were studied in their occupation and continuously involved in working and prolonged standing showed muscular effect. We found that male (91.25%) patients were dominant than the female. The right limb was involved in 18 cases and the left limb in 61 cases. The most common symptom was pain with prominent veins which occurred alone or in combination with oedema, eczema, pigmentation or ulceration. Conclusion: This study reveals that the disease is more prevalent during the active adult life in their 3rd and 4th decades and males were more affected. The occupations needing prolonged standing and use of violent muscular efforts is found to be a contributing or precipitating factor for varicose veins. The commonest symptoms in the study were prominent swellings in the lower limb and pain. Definite relationship exists between occupation involving prolonged standing and primary varicose veins. The involvement of long saphenous and communicating system is commonest followed by long saphenous involvement alone.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2019, title = {A study on efficiency and sensitivity of evaluation and post-operative management of varicose veins: a prospective observational study}, author = {Saniya Ahmed and Saif Mohammed Khan}, url = {https://www.surgeryscience.com/articles/210/3-4-2-346.pdf}, doi = {10.33545/surgery.2019.v3.i4a.210}, issn = {2616-3462}, year = {2019}, date = {2019-09-14}, urldate = {2019-09-14}, journal = {International Journal of Surgery Science}, volume = {3}, issue = {4}, pages = {11-17}, abstract = {Background: The present study was conducted with the aim to evaluate the clinical features and management of varicose veins in terms of recurrence and symptoms improvement. Methodology: It was a prospective study; fifty cases of varicose veins were attending outpatient Department and admitted in the Surgical Department of Deccan College of Medical Sciences & Hospital from October 2018 to September 2019. Results: In the present study, out of the 55 limbs examined and investigated, 7 limbs (12.72%) found to have suffered from deep vein thrombosis. Out of these 3 (5.4%) were found on clinical examination while investigations revealed deep vein thrombosis in 4 (7.2%) limbs. Routine investigations were carried out to evaluate patients’ fitness for surgery. Out of 50 patients 2 (5.5%) were unfit because of severe cardiac problem. The colour doppler study was done in all cases of which, in 12 cases (21.81%) an additional information was found. Out of these in two patient (16.66%) two perfortors missed on clinical examination was detected while in 6 patients (50%) additional information about perforator competency was found. Four patients have got additional information about deep vein patency. The accuracy of colour doppler in detecting SFJ and SPJ incompetence was 100%. By colour doppler, a total of 21 sites were marked as incompetent perforators, out of which 19 were found correct on exploration (90.47%specificity). Abdominal ultrasonography was performed in all patients. No abnormality was found in 49 of them while one had small left renal calculus. Various combinations of operations were carried out, according to the site of pathology determined by clinical examination and investigations. In our study, out of 55 limbs affected, only 14 limbs were operated upon. Out of 55 limbs, 41 were (74.54%) treated conservatively. Majority of them 29 were (64.1%) relieved of the symptoms by conservative method. From total 50 patients, 23 were treated on out Patients basis while 27 patients (46%) needed admission for either operative purpose or for ulcer healing. The average stay with 13 patients (45%) having ulcer was l5days. Stay was shorter in 14 patients (55%) who were not having ulcer, was average 11days. In the present study, only early post operative complications were noted in the post operative hospital stay in all the 14 patients, of this 1 patient (7.14%) developed wound infection. Only late post operative complications were noted during the follow-up period on outpatient basis. There were no mortalities noted in the intra-operative or the immediate postperative period. Conclusion: A good clinical assessment with investigations, treatment of associated complications and a combination of surgical procedures have beneficial effects in minimizing cost and morbidity of varicose vein surgery.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Dhar_2019, title = {Bronchiectasis in India: results from the European multicentre bronchiectasis audit and research collaboration (EMBARC) and respiratory research network of India registry}, author = {Raja Dhar and Sheetu Singh and Deepak Talwar and Murali Mohan and Surya Kant Tripathi and M. Aleemuddin Naveed and Ashfaq Hasan}, url = {https://www.thelancet.com/action/showPdf?pii=S2214-109X%2819%2930327-4}, issn = {2214-109X}, year = {2019}, date = {2019-09-01}, urldate = {2019-09-01}, journal = {Lancet Global Health}, volume = {7}, pages = {e1269-e1279}, abstract = {Background: Bronchiectasis is a common but neglected chronic lung disease. Most epidemiological data are limited to cohorts from Europe and the USA, with few data from low-income and middle-income countries. We therefore aimed to describe the characteristics, severity of disease, microbiology, and treatment of patients with bronchiectasis in India. Methods The Indian bronchiectasis registry is a multicentre, prospective, observational cohort study. Adult patients (≥18 years) with CT-confirmed bronchiectasis were enrolled from 31 centres across India. Patients with bronchiectasis due to cystic fibrosis or traction bronchiectasis associated with another respiratory disorder were excluded. Data were collected at baseline (recruitment) with follow-up visits taking place once per year. Comprehensive clinical data were collected through the European Multicentre Bronchiectasis Audit and Research Collaboration registry platform. Underlying aetiology of bronchiectasis, as well as treatment and risk factors for bronchiectasis were analysed in the Indian bronchiectasis registry. Comparisons of demographics were made with published European and US registries, and quality of care was benchmarked against the 2017 European Respiratory Society guidelines. Findings: From June 1, 2015, to Sept 1, 2017, 2195 patients were enrolled. Marked differences were observed between India, Europe, and the USA. Patients in India were younger (median age 56 years [IQR 41–66] vs the European and US registries; p<0∙0001]) and more likely to be men (1249 [56∙9%] of 2195). Previous tuberculosis (780 [35∙5%] of 2195) was the most frequent underlying cause of bronchiectasis and Pseudomonas aeruginosa was the most common organism in sputum culture (301 [13∙7%]) in India. Risk factors for exacerbations included being of the male sex (adjusted incidence rate ratio 1∙17, 95% CI 1∙03–1∙32; p=0∙015), P aeruginosa infection (1∙29, 1∙10–1∙50; p=0∙001), a history of pulmonary tuberculosis (1∙20, 1∙07–1∙34; p=0∙002), modified Medical Research Council Dyspnoea score (1∙32, 1∙25–1∙39; p<0∙0001), daily sputum production (1∙16, 1∙03–1∙30; p=0∙013), and radiological severity of disease (1∙03, 1∙01–1∙04; p<0∙0001). Low adherence to guideline-recommended care was observed; only 388 patients were tested for allergic bronchopulmonary aspergillosis and 82 patients had been tested for immunoglobulins. Interpretation Patients with bronchiectasis in India have more severe disease and have distinct characteristics from those reported in other countries. This study provides a benchmark to improve quality of care for patients with bronchiectasis in India.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Begum_2019, title = {Abdominal wall tumours-primary or secondary: a case report}, author = {Rabiya Begum and Ganji Ravi and Syed Mujtaba Ibrahim}, url = {https://www.researchgate.net/publication/335860976_ABDOMINAL_WALL_TUMOUR-_PRIMARY_OR_SECONDARY_A_CASE_REPORT}, issn = {2349-2562}, year = {2019}, date = {2019-08-31}, urldate = {2019-08-31}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {6}, issue = {32}, pages = {2195-2197}, abstract = {60-year-old male patient, farmer by occupation, with no comorbidities presented with recurrent abdominal swelling of 4 years duration with history of pain in the swelling since previous 2-3 months. He was earlier operated for a swelling at the same site 7 years before in a hospital in a neighbouring small town. Neither the details of that procedure were available, nor it was known the specimen was sent for histopathological examination or not.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kehkashan_2019b, title = {A study on postoperative complications following major obstetrics and gynaecological surgeries}, author = {Anjum Kehkashan and D. Sravani and Fawwad M. Shaikh}, url = {https://www.medpulse.in/Gynacology/html_11_2_8.php}, issn = {2579-0870}, year = {2019}, date = {2019-08-31}, urldate = {2019-08-31}, journal = {MedPulse – International Journal of Gynaecology}, volume = {11}, issue = {2}, pages = {76-81}, abstract = {Background: Any surgical procedure carries risks of complications. The risk of postoperative complications depends on individual characteristics, including: age, medical comorbidities, and functional status. They need to be reduced because they contribute to morbidity and mortality. Adverse events that are closely related to processes of care, such as postoperative complications, may be a better measure of quality than death rates or other intermediate out comes (1).Aim of The Study: To study incidence of post operative complications and surgical care following major obstetric and gynaecological surgeries. Objectives: 1. To know different types of post operative complications following major obstetric and gynaecological surgeries.2. To know the relative incidence of such post operative complication.3To Study factors that are associated with post operative complications such as obesity, blood loss and duration of surgery (more than or less than 02hours)Materials And Method: An observational study was conducted at Owaisi Hospital and Princess Esra hospital in the Department of Obstetrics and Gynecology from August 2016 to January 2018. The study included all the patients undergoing major surgeries for either obstetric or gynaecological indication. Results: The study focused on the post operative complications following major obstetric and gynaecological surgeries. The following are the complications observed in the present study. Overall the post operative complications observed are very low. 8.6% of total cases showed febrile morbidity, the highest recorded complication. Vault hemorrhage was 4.4% (4 of 84 patients of hysterectomy) followed by lap surgery converted to open surgery (2.3% of 129 lap surgeries). Surgical site infections are expected to be high in any surgeries but in the present study only 1.6% of the cases had developed this complication. Blood transfusion and blood loss more than 1000ml was in 1.8% of the cases. Urinary retention after open surgery and laparoscopic surgery occurred in 1.7% and 4.6%, respectively. Conclusion: The incidence of post operative complications can be reduced by 1.Proper selection of the patient2. Pre-operative evaluation of the patient3.Improve nutritional status and hygiene of the patient prior to surgery.4. Intra operatively - maintain sterility, good surgical technique, reducing blood loss and strict vigilance of unavoidable complications.5. Post operatively adequate analgesia, fulfillment of hydration, antibiotics, starting drugs for co-morbid conditions and monitoring of patient for development of any complications.}, keywords = {Community Medicine, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Faisauddin_2019, title = {An adult kawasaki disease with coronary artery involvement: a unique case report and literature review}, author = {Mohammed Faisaluddin and Pulwasha M. Iftikhar and Azadeh Khayyat and Javidulla Khan and Azeem H. Arastu}, url = {https://www.cureus.com/articles/22589-an-adult-kawasaki-disease-with-coronary-artery-involvement-a-unique-case-report-and-literature-review#!/}, doi = {10.7759/cureus.5529}, issn = {2168-8184}, year = {2019}, date = {2019-08-30}, urldate = {2019-08-01}, journal = {Cureus}, volume = {11}, issue = {8}, pages = {e5529}, publisher = {Cureus, Inc.}, abstract = {Kawasaki disease (KD) is an acute, febrile, vasculitis of mainly large to medium-sized vessels. KD is a self-limited illness of infancy and childhood and 80% of the patients are younger than four years of age with an incidence of 5.6/100,000 in the United States. We present an unusual case of an 18-year-old man with several unique features of KD. He was admitted to the hospital with fever, rash, and arthralgia for one week. KD was among the differentials for fever, rash, and arthralgia. Later all the laboratory diagnosis for bacterial and viral infections including blood and urine culture came out negative and he was further evaluated for KD with electrocardiography (EKG), echocardiography, and angiography which showed myocarditis. Based on typical features of fever, rash, arthralgia, bilateral conjunctival injection, cervical lymphadenopathy, and prominent tongue papillae he was diagnosed with KD.}, key = {pmid31687304}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohan_2019c, title = {Study of management of supracondylar femoral fracture using dynamic condylar screw}, author = {Lalith Mohan and Ramesh Bengaluri}, url = {https://www.ijoro.org/index.php/ijoro/article/view/1158/679}, doi = {10.18203/issn.2455-4510.IntJResOrthop20193827 }, issn = {2455-4510}, year = {2019}, date = {2019-08-26}, urldate = {2019-08-26}, journal = {International Journal of Research in Orthopaedics}, volume = {5}, issue = {5}, pages = {869-874}, abstract = {Background: Supracondylar femoral fracture poses a considerable therapeutic challenge. Operative treatment has become a standardized procedure. Stabilization has usually been achieved by an osteosynthesis with dynamic condylar screws or retrograde supracondylar nailing. In this article we are going to compare the results of surgical management of supracondylar nail and dynamic condylar screw. The aim is to study the effectiveness of dynamic condylar screw in surgical management of supracondylar fractures of femur. Methods: Prospective study of patients who had sustained supracondylar fracture of femur. The patients included in this study were those with supracondylar fractures of the femur with or without articular involvement and disruption of the joint surface. Study was done for a period of two and half years. Results: In our study of 21 cases, there were 8 patients (38%) who had associated fractures. Two patients were more than 50 yrs. 3 patients had compound injury which were grade-II of Gustilo Anderson classification. One of them developed post-operative infection and resulted in poor outcome. Other 2 patients had decrease range of movements resulted in fair outcome. Type C2 constituted highest number 8 (38%) followed by type A3 which was 28.5% i.e., 8 patients. Infection is observed in 9.5% of patients. 2 patients had implant failure and both were due to early weight bearing. In our study excellent and good results were found to be in 61.9%. Conclusions: Role of dynamic compression screw in the surgical management of supracondylar fractures of the femur minimizes the risk of complications.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Faisaluddin_2019, title = {A rare case report of biloma after cholecystectomy}, author = {Mohammed Faisaluddin and Roopam Bansal and Pulwasha M. Iftikhar and Javidulla Khan and Azeem H. Arastu }, url = {https://www.cureus.com/articles/22564-a-rare-case-report-of-biloma-after-cholecystectomy#!/}, doi = {10.7759/cureus.5459}, issn = {2168-8184}, year = {2019}, date = {2019-08-22}, urldate = {2019-08-01}, journal = {Cureus}, volume = {11}, issue = {8}, pages = {e5459}, publisher = {Cureus, Inc.}, abstract = {Biloma is an encapsulated collection of bile outside or inside the biliary system within the abdominal cavity. It is a rare condition with an incidence of 0.3%-2%. The most common cause of spontaneous biloma is choledocholithiasis, and other causes include abdominal trauma and surgery, bile duct tumors, liver infarction, percutaneous catheter drainage, transhepatic cholangiogram and endoscopic retrograde cholangiopancreatography (ERCP) but the exact cause is yet to be discovered. We herein present a case report of biloma as a complication of laparoscopic cholecystectomy. A 58-year-old male presented to our hospital emergency room with complaints of fever, nausea, vomiting, and pain in the right upper quadrant after six weeks of laparoscopic cholecystectomy for cholecystitis. He was diagnosed with computed tomography (CT) scan quickly, and he has treated with pigtail catheter percutaneous drainage. On a follow-up visit, after four weeks, his abdominal pain had improved and white blood count was also reduced to baseline., isbn/issn = 2168-8184}, key = {pmid31656709}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Basha_2019b, title = {Evaluation of efficacy of triamcinolone acetate intra articular therapy for knee osteoarthritis: a case control study}, author = {Md. Jaan Basha and Venkat Lakavath}, url = {https://jmscr.igmpublication.org/v7-i7/44%20jmscr.pdf}, doi = {10.18535/jmscr/v7i7.44}, issn = {2347-176X}, year = {2019}, date = {2019-07-31}, urldate = {2019-07-31}, journal = {Journal of Medical Science and Clinical Research}, volume = {7}, issue = {7}, pages = {223-227}, abstract = {Knee osteoarthritis constitutes a public health concern of immense dimensions, and places a burden on society similar to few other conditions. Corticosteroids are used for treatment. The aim of this study is to evaluate efficacy of intra-articular triamcinolone injections for osteoarthritis of the knee. This is a double blind, prospective, randomized, and controlled study conducted at Deccan college of medical sciences, Hyderabad after obtaining permission from the hospital ethics committee. This study includes 60 patients of both sexes aging from 50-70 years. These patients were divided in two groups randomly by the closed-envelope technique. Diagnosis was done using Kellgren and Lawrence scale for osteoarthritis. The efficacy of pain relief in the 2 groups were compared using Visual analog score (VAS), Oxford knee Score and McGill Quality of life score followed upto 6 months. The study group was given 40mg of 1ml triamcinolone acetate and compared with control normal saline. The base line parameter VAS scores (6.03±1.36 &6.43±1.02) Oxford knee Score (44.46±4.02 & 45.23±5.23) and QOL scores (86.03±4.36 and 85.36±5.32) were comparable. The use of triamcinolone decreased the pain and pain relief was satisfactory to patients and it also improved the Quality of life score up to 6 months.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2019, title = {Clinical profile of patients with Parkinsons disease in Hyderabad region}, author = {Sandhya Manorenj}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=July_2019_1561808429_4306180.pdf}, issn = {2277-8179}, year = {2019}, date = {2019-07-31}, urldate = {2019-07-31}, journal = {International Journal of Scientific Research}, volume = {8}, issue = {7}, pages = {12-14}, abstract = {INTRODUCTION: Parkinson disease (PD) is the second most common neurodegenerative disorder that causes progressive motor and non-motor disability. This condition is diagnosed clinically and is characterized by the presence of bradykinesia, accompanied either by rest tremor or rigidity. The present study aimed to provide the demographic and clinical profile of PD in patients from Hyderabad and also to create a database on PD in this region. METHODS: A prospective cross-sectional hospital based study was conducted over a period of 3 years commencing in December 2014. The study included cases of PD diagnosed in accordance with the United Kingdom PD Society Brain Bank criteria and analyzed its demographic and clinical features. RESULTS: 40 patients (26 males, 14 females) were found to have features compatible with PD. The average age at onset was 51.55± 10.18 years. Majority of patients had onset of PD at an older age (≥50 years; 24 patients, 60%) when compared to the rest who were younger (age<50 years, 16 patients, 40%).The most common initial symptom was tremor (36 patients, 90 %). Postural instability was observed in 22% patients. The average progression from mild to moderate/severe PD (stage3) was seen to be 3.8±5 years among the young and 3.7±3.2 years among the older patients. Non motor feature of PD was observed in 25% patients and the most common non motor feature was found to be disturbance in sleep (15%). CONCLUSION: Unilateral limb tremor was seen to be the most common initial symptom and disturbance in sleep was the most common non motor symptom. Male predominance and older onset of PD was observed in this region. }, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2019, title = {Serum levels of Magnesium, Copper, Zinc and Iron in patients with essential hypertension}, author = {Tamkinath Fatima and Syyeda Anees}, url = {https://saudijournals.com/media/articles/SIJB_27_205-208_c.pdf}, doi = {10.36348/sijb.2019.v02i07.003}, issn = {2616-8650}, year = {2019}, date = {2019-07-30}, journal = {Scholars International Journal of Biochemistry}, volume = {2}, issue = {7}, pages = {205-208}, abstract = {Hypertension (HTN) is an asymptomatic easily detectable chronic cardiovascular disorder which can cause coronary heart diseases, stroke and other complications. The relationship between trace elements and cardiovascular diseases is under investigation and showed conflicting results.In this study levels of magnesium, copper, zinc, iron in hypertensives were estimated and compared with normal healthy controls. A case control study was undertaken over a period of 6 months included 100 individuals aged between 25-65 years. 50 cases were hypertensive patients free from diabetes mellitus, thyroid disorders, any other chronic diseases, while 50 normal healthy subjects were controls. In both the groups, systolic and diastolic blood pressures, serum magnesium, copper, zinc and iron levels were obtained. The systolic and diastolic blood pressure, serum copper, zinc was significantly high (p value <0.05) and magnesium, iron levels were significantly low in hypertensives. Excess free radicals, increased stress has been implicated in the etio-pathogenesis of hypertension. Copper and iron increase the levels of free radicals acting as a pro-oxidant leading to increased peripheral vascular resistance and hypertension. Increased zinc can be due to intracellular increase in renal zinc favoring the activity of carbonic anhydrase and causing an effect opposite to that of some diuretics. Elevated zinc leads to high sympathetic nervous activity. Decreased magnesium potentiates vasoconstriction and increase vascular tone leading to hypertension. We conclude that there exists a relationship between serum magnesium, copper, zinc, iron and hypertension but, further large-scale population studies should be undertaken to establish the role of various trace elements in hypertension.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2019, title = {Hemolytic uremic syndrome: A case report}, author = {Safa Fatima and Ahmad Muhammad and Juveria Khaleel}, url = {https://meddocsonline.org/journal-of-case-reports-and-medical-images/hemolytic-uremic-syndrome-a-case-report.html}, doi = {10.33582/2639-9237/1020}, issn = {2639-9237}, year = {2019}, date = {2019-07-25}, urldate = {2019-07-25}, journal = {Journal of Case Reports and Medical Images}, volume = {2}, number = {2}, pages = {1020}, abstract = {Hemol ytic Uremic Syndrome (HUS), is characterised by a triad of three main factors, microangiopathc haemolytic anemia, thrombocytopenia and acute kidney injury. Multiple aetiologies can cause this triad of symptoms; hence HUS is a group of disorders with similar clinical features. Paediatric age group is the most commonly affected, and STEC- HUS, which is HUS caused by E coli, which produces shiga like toxin, is the most common cause of infectious HUS in children. Though it has a multitude of etiological factors, Heamolytic Uremic Syndrome (HUS) as an entity has only a supportive treatment. }, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2019, title = {A comparative study of central and peripheral arterial parameters in hypertensive patients on angiotensin receptor blockers and calcium channel blockers}, author = {K. Laxman Rao and Mohammed Abdul Hannan Hazari and Bachi Tazneem and Ahmed Abdul Aziz and Asiya Mohtesham and A. Afreen and Kethavath Priyanka}, url = {https://www.jhrr.org/article.asp?issn=2394-2010;year=2019;volume=6;issue=2;spage=76;epage=81;aulast=Rao;type=0}, doi = {10.4103/0028-3886.263243}, issn = {2394-2010}, year = {2019}, date = {2019-07-23}, urldate = {2019-07-23}, journal = {Journal of Health Research and Reviews}, volume = {6}, issue = {2}, pages = {76-81}, publisher = {Wolters Kluwer - Medknow}, abstract = {Aims: Untreated or inappropriately managed hypertension (HTN) is a significant risk factor for all-cause morbidity and mortality due to its complications. For proper management of HTN, timely diagnosis and classification into appropriate category is crucial. According to hypertensive class category, pharmacological therapy can be initiated according to the national or international guidelines. Various antihypertensive medications have differential effects on peripheral and central arterial parameters. Our study was aimed at comparing the effects of two classes of antihypertensive drugs, i.e., angiotensin receptor blockers (ARBs) and calcium channel blockers (CCBs). Materials and Methods: Hypertensive patients on monotherapy – ARBs (Group 1, n = 35) and CCBs (Group 2, n = 35) – over the age of 18 years, belonging to both genders, were recruited. Results: Heart rate and peripheral and central arterial pressures were lower in Group 2 compared to Group 1; ankle brachial index and carotid-femoral pulse wave velocity were less in Group 1 in comparison with Group 2; but these differences were statistically not significant. Conclusions: We conclude that the two groups of drugs were equally effective in blood pressure reduction, both in central and peripheral arteries.}, keywords = {Cardiology, Deccan School of Pharmacy, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2019, title = {Assessment of neurocognitive impairment in obstructive sleep apnea}, author = {Nazia Uzma and Juhi Fatima Sultan and Nooruddin Owaisi and Mariya Syed and Abid Ali Khan and Ashfaq Hasan}, url = {https://ijop.net/index.php/ijop/article/view/217}, doi = {10.37506/ijop.v7i2.217}, issn = {2320-6039}, year = {2019}, date = {2019-07-20}, urldate = {2019-07-01}, journal = {International Journal of Physiology}, volume = {7}, issue = {2}, pages = {126-130}, abstract = {Sleep apnea is usually reported in south Indian population. The indications of obstructive sleep apnea (OSA) comprise of breathing difficulties particularly owing to obstruction in the upper airway tract. The present study investigated the effect of the syndrome, the patients documented with OSA, by categorizing the patients into mild, moderate and severe OSA groups depending on apnea-hyponea index (AHI), derived from sleep study (polysomnographic findings). The comparative evaluation of various outcomes considered in this study included healthy individuals (control group, AHI < 5), mild OSA (AHI 5–15), moderate (OSA 15–30) and severe (AHI > 30). Investigations were conducted on the subjects which evaluated baseline characteristics, polysomnographic data and neuro-cognitive performances by Mini-Mental State Examination (MMSE). The results revealed significantly higher body mass index (BMI), snoring and decresed sleep efficiency in patients with sleep apnea syndrome when compared with control group. OSA patients further exhibited compromised neuro-cognitive. The intensity of the impairments and difficulties increased with upsurge in severity of the syndrome among all patients. The findings of this work strongly indicated that impaired executive functioning; neuro-cognitive abnormalities exit in a heightened state among OSA patients, than in the normal healthy individuals, the control group. These findings in aggregate would help clinicians in diagnosis and in understanding the disease prognosis.}, keywords = {Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Basha_2019, title = {Evaluation of osteoporosis and osteopenia in elderly people in Hyderabad region}, author = {Md. Jaan Basha and Venkat Lakavath}, url = {https://www.saspublishers.com/article/10789/}, doi = {10.36347/sjams.2019.v07i07.010}, issn = {2320-6691}, year = {2019}, date = {2019-07-19}, urldate = {2019-07-19}, journal = {Scholars Journal of Applied Medical Sciences}, volume = {7}, issue = {7}, pages = {2312-2316}, abstract = {The aim of this study is to evaluate the incidence of osteoporosis, evaluation of BMD, T-Score, associated serum biochemical factors &socio economic factors in 40 years above men &women. This is a cross sectional study conducted at Princess Esra hospital, Deccan College of medical sciences, Department of orthopedics, after taking informed consent from patients and after obtaining hospital ethics committee permission. In these study 100 patients both males and females above 40 yrs of age presenting with various conditions of non-autoimmune musculoskeletal pains were included in the study. In this study Calcaneal Quantitative Ultrasound (QUS) device used to examine the BMD and the T-score threshold at lumbar spine and femoral neck. In our study, 30% of patients were suffering with osteoporosis and 25% with osteopenia. In males 13% & 10% were suffering with osteoporosis and osteopenia respectively. In females 17% & 15% were suffering with osteoporosis and osteopenia respectively. The BMD and T-scores in males at lumbar spine (1.12±0.14 and -0.7±0.9) and femoral neck (0.93±0.2 and -0.7±0.2), in females at lumbar spine (1.08±0.12and -0.9±1.2) and femoral neck (0.93±0.2 and -1.0±1.1) are comparatively equal. The serum alkaline posphotase, Total cholesterol, uric acid, vitamin D, Calcium also influence the osteoporosis. The socioeconomic factors like occupation, education and physical activity also influence the osteoporosis and osteopenia.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Kilaru_2019, title = {Active pulmonary tuberculosis presenting with acute respiratory failure}, author = {Satish Chandra Kilaru and Sudhir Prasad and Hemanth Kilaru and Raghavender Reddy Anneela and Ashfaq Hasan and Eshwar Chandra Nandury}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635142/pdf/RCR2-7-e00460.pdf}, doi = {10.1002/rcr2.460}, issn = {2051-3380}, year = {2019}, date = {2019-07-16}, urldate = {2019-07-16}, journal = {Respiratory Case Reports}, volume = {7}, issue = {7}, pages = {1-5}, abstract = {Four patients with active pulmonary tuberculosis (PTB) presenting with respiratory failure are reported here. Bronchogenic PTB, simulating an acute febrile illness or diffuse interstitial lung disease with short duration of symptoms, as a cause of acute respiratory failure is less recognized. If diagnosed and treated early, it has good prognosis. Three of the four patients presented here had an acute presentation with fever, dyspnoea, and hypoxemia with diffuse infiltrative lesions on radiography, and the other younger patient presented predominantly with lobar consolidation. These patients presenting with respiratory failure required intensive care management, and a diagnosis was made with bronchoalveolar lavage fluid and transbronchial lung biopsy. All four patients promptly received antitubercular therapy, showed clinicoradiological improvement, and were stable at 1 year follow up. }, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2019, title = {Prevention of complications in Type II diabetes mellitus by measuring glycated hemoglobin, 24 hours urinary protein and protein creatinine ratio and fundus examination}, author = {Tahmeen Jameel and Syed Mahmood Ahmed and Aiman Mahmood and Mahbub Unnisa}, url = {https://www.iosrjournals.org/iosr-jbb/papers/Volume%205,%20Issue%204/C0504012022.pdf}, doi = {10.9790/264X-0504012022}, issn = {2455-264X}, year = {2019}, date = {2019-07-16}, urldate = {2019-07-16}, journal = {IOSR Journal of Biotechnology and Biochemistry}, volume = {5}, issue = {4}, pages = {20-22}, abstract = {The measurement of glycated hemoglobin, 24 hours urinary protein and protein creatinine ratio serves as an important index in the monitoring of diabetes patients to prevent the complications. Screening patients for Retinopathy is again very important. The cause of diabetic complication is not known. Major emphasis has been placed on the polyol pathway where in glucose is reduced to sorbitol by the enzyme aldolase reductase with reduced NADPH as the electron donating coenzyme. Sorbitol molecule is oxidized to fructose by the enzyme Sorbitol dehydrogenase and reduced NAD+ . Sorbitol appears to function as a tissue toxin and has been implicated in the pathogenicity of retinopathy, neuropathy and cataract. Among the clinically important secondary microvascular complications of diabetes, kidney as the target organ represents a health problem of enormous social cost. Nephropathy like other diabetic complications is probably influenced by genetic factors. 35% of NIDDM patients develop nephropathy. Diabetic nephropathy is duration dependent and extends over many years before becoming clinically evident. Persistent proteinuria appears to predict evidence of kidney damage. Proteinuria is the most widely accepted sign of diabetic nephropathy. Spot protein, creatinine ratio would be more accurate and less time consuming. Diabetic nephropathy is leading cause of morbidity and premature mortality in diabetes subjects. Diabetic nephropathy has an insidious onset with increase in glycated hemoglobin before the appearance of microalbuminuria.}, keywords = {Biochemistry, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Syeda_2019, title = {Evaluations of antidepressant activity of nerium oleander flower extract in albino mice}, author = {Shakira Fathima Syeda and Pushpalatha C. and Mohammed Mohsin}, url = {https://www.ijsr.net/archive/v8i7/ART20199502.pdf}, issn = {2319-7064}, year = {2019}, date = {2019-07-01}, urldate = {2019-07-01}, journal = {International Journal of Science and Research}, volume = {8}, issue = {7}, pages = {979-980}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2019c, title = {Intracellular divalent ion oscillations: Is this the key phenomenon in rhythm generators?}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v3i2.54657}, doi = {10.23921/amp.2019v3i2.54657}, issn = {2456-8422}, year = {2019}, date = {2019-06-30}, urldate = {2019-06-30}, journal = {Annals of Medical Physiology}, volume = {3}, issue = {2}, pages = {19-20}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019e, title = {Musculoskeletal tuberculosis: a diagnostic approach}, author = {Mohammed Jalal Mohiuddin and Syed Farooq Iftekhar Ahmed and Jawad Mirza and Abdul Hai Mohammed and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2019/vol5issue3/PartB/5-2-75-504.pdf}, doi = {10.22271/ortho.2019.v5.i3b.1515}, issn = {2395-1958}, year = {2019}, date = {2019-06-30}, urldate = {2019-06-30}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {3}, pages = {94-96}, abstract = {Musculoskeletal tuberculosis constitutes 3 percent of extra pulmonary secondary tuberculosis predominantly involving the spine. The variations in its presentation and unclear symptoms make diagnosis difficult in early period. The normal lab values like ESR, TLC, DLC and no clear history of previous pulmonary infection makes the picture unclear and delays the diagnosis. Present work is the overview of the presentation of various musculoskeletal presentations, efficacy of BCG vaccination, time delay in diagnosis, laboratory parameters, x rays and other radiological changes etc. The reliability of the various lab procedures like AFB stain, histopathology, tuberculosis bacteria culture and cartridge-based nucleic acid amplification test (CBNAAT) has also been overviewed. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Durga_2019, title = {Dietary pattern in adult patients with acute stroke in South India: a case-control study from a tertiary care center in Hyderabad}, author = {Adabala Vijaya Durga and Sandhya Manorenj}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454960/?report=reader}, doi = {10.4103/jnrp.jnrp_237_18}, issn = {0976-3147}, year = {2019}, date = {2019-06-30}, urldate = {2019-06-30}, journal = {Journal of Neurosciences in Rural Practice}, volume = {10}, issue = {2}, pages = {283-293}, abstract = {Background and Objective: Diet plays a crucial role in the occurrence of stroke. But very few studies have so far been conducted with focus on this aspect of acute stroke in India. The objective of the study was to identify the dietary pattern in patients with acute stroke in South India. Materials and Methods: Patients with first-ever acute stroke (ischemic and hemorrhagic) admitted between June 2017 and November 2017 were enrolled and compared with age- and sex-matched controls. Information was collected using a pro forma. Results: Out of 293 acute stroke patients, 150 were enrolled and compared with 150 controls. The mean age was 52.3 ± 12.6; years 112 (74.6%) patients were male. The majority of them were on traditional diet that included a daily intake of rice (98.6%) and pulses (40.6%). Hypertension (73.3%) was the major vascular risk factor for stroke (P < 0.0001). Significant differences were observed in risk factors such as diabetes (P < 0.0001), smoking (P = 0.0001), alcohol use (P = 0.0017), and heart disease (P = 0.0002), when stroke patients were compared with controls. Stroke patients reported a lower intake of green leafy vegetables (P = 0.0001; odds ratio [OR] 0.17), roots and tubers (P = 0.0016; OR 0.21), and fruits (P = 0.0022; OR 0.29). There was at the same time a higher intake of red meat products (P = 0.04; OR 2.41), organ meats (P = 0.0093; OR 4.35), fried snacks (P = 0.0038; OR 2.01), and pickles (P = 0.04; OR 1.81) although the data suggested lesser consumption of prawn and crab (P = 0.04; OR 0.55) and water (P = 0.0001 OR 4.59) among stroke patients. Higher consumption of fruit juices (P = 0.0008) and junk foods (P = 0.03) was observed in young stroke patients (age ≤45 years) whereas the intake of chicken (P = 0.03) and alcohol (P = 0.0001) was observed to be more among men than among women. Conclusion: Majority of stroke-afflicted patients in South India consume white rice and dal. There is lower intake of water, green leafy vegetables, and fruits and higher consumption of red meat, organ meat, and pickles among stroke patients.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Manorenj_2019b, title = {Clinical characteristics of essential tremor in South India: a hospital-based cohort study}, author = {Sandhya Manorenj and Chintha Shravani and Srikant Jawalkar}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454942/?report=reader}, doi = {10.4103/jnrp.jnrp_348_18}, issn = {0976-3147}, year = {2019}, date = {2019-06-30}, urldate = {2019-06-30}, journal = {Journal of Neurosciences in Rural Practice}, volume = {10}, issue = {2}, pages = {245-249}, abstract = {Introduction: Essential tremor (ET) is the most common adult movement disorder. Classic ET is characterized by action tremor of hands (95% cases), and tremor involving other regions is less common. Recent studies have revealed a few patients exhibiting nontremor features that include cognitive disorders, tandem gait abnormality, mood fluctuations, olfactory abnormality, hearing impairment, and sleep disorders. Very few studies on ET have so far been conducted in India, and the present study is a pioneering attempt to evaluate the clinical characteristics of patients diagnosed with ET. Materials and Methods: A standardized assessment protocol was used to collect data. Diagnosis of ET was established using consensus criteria established by the Movement Disorder Society. Tremor Research Group Essential Tremor Rating Assessment Scale was used to evaluate tremor impact. The severity of hand tremor was assessed by Glass Scale, and cognitive function was assessed by Mini–Mental Status Examination. Results: Out of the 45 patients enrolled, 73.3% were male and 26.6% were female, with a mean age of 44 ± 15 years. Postural tremor was observed in all, followed by intention tremor in 9 and rest tremor in 6 patients. Tremor of the hand was identified to be most predominant (100%). Voice tremor was observed in 15 (33.3%) patients and head tremor in 12 patients (26.6%) who were all females. Leg tremor was observed in 12 patients (26.6% of patients) and tongue tremor in 6 (13%) patients. Baseline asymmetry of tremor was observed in 60% of patients and positive family history in 35% of patients. The most common nontremor feature was tandem gait abnormality (40%). Moreover, most of the patients had Glass Scale II. Conclusion: Baseline asymmetry of tremor and male predominance were observed in the study. While hand tremor was the most common form of tremor, tandem gait abnormality was the most common nontremor feature as observed in patients with ET.}, keywords = {Neurology}, pubstate = {published}, tppubtype = {article} } @article{Mohan_2019, title = {Plantar fasciitis-role of intra-lesional steroids injection with multiple puncture technique}, author = {Lalith Mohan and Mohammed Jalal Mohiuddin and Hassan Rafeeq and Chavva Shamsunder and Aslam Mohsin}, url = {https://www.orthopaper.com/archives/2019/vol5issue3/PartN/5-3-115-804.pdf}, doi = {10.22271/ortho.2019.v5.i3n.1633}, issn = {2395-1958}, year = {2019}, date = {2019-06-23}, urldate = {2019-06-23}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {3}, pages = {822-823}, abstract = {Plantar fasciitis is one of the common OPD presentations in orthopedics. It affects the productivity of the patients due to its chronic and resistant nature. There is no reproducible investigation for the diagnosis. It remained the diagnosis of exclusion and most of the time clinical based. There are various treatments available which includes local Ultrasound therapy, MCR (microcellular rubber) sole, silicon soles, Intralesional steroid and PRP (platelet rich plasma). Present study described the modified technique of micro punctures along plantar fascia origin at the time of steroid administration. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Lodhi_2019, title = {Voglibose and its significance in prediabetes: an observational study}, author = {Mohammed Mansoor Ali Khan Lodhi and Anjum Sultana Khatoon}, url = {https://www.medicalsciencejournal.com/assets/archives/2019/vol5issue8/5-8-27-875.pdf}, issn = {2454-9142}, year = {2019}, date = {2019-06-22}, urldate = {2019-06-22}, journal = {International Journal of Medical and Health Research}, volume = {5}, issue = {8}, pages = {153-154}, abstract = {Aim: to achieve glycemic control in prediabetic patient with Alpha glucosidase inhibitors who are risk of developing frank diabetes mellitus. Material and Methods: In the present study a total of 150 prediabetic patients were selected out of which only 100 participants were eligible for study. Inclusion Criteria: 1) Age: 20-60yrs, 2) FBS: 101-125mg/dl, PPBS: 141 -199mg/dl, 3) BMI: 24-29 4) HbA1c: 5.7-6.4%. Exclusion Criteria: 1) Known Diabetic 2) Any h/o of intake of oral Hypoglycemic Agents 3) Preexisting CAD, Renal Dysfunction, Hepatic Dysfunction, Gastro-intestinal Disorders. Results: 100 eligible patients were enrolled as per Inclusion criteria, they were divided into two groups, Group 1 (n=53) was placed on Diet, lifestyle modification and Voglibose 0.3mg twice a day, whereas the Group B (n=47) was placebo group. The mean duration of treatment was 24·6 weeks (SD 18.4)—i.e.23.6 weeks (17·5) for voglibose and 25·4 weeks (18.9) for placebo. In group A (n=53), there were 23 males (43.39%), and 30 female subjects (56.60%), whereas in the placebo arm (n=47), there were 20 males (42.55%), 27 Female (57.44%). In the analysis, we found that patients on voglibose was better and the glycemic control was within the standard recommended lines than placebo in individuals Conclusion:A systematic approach and close monitoring that increased the adherence to medication, diet, and counselling would help in better glycemic control and prevent long term complication. In patient with prediabetes, early intervention with medication can prevent long term complication and also prevents or delays the onset of frank diabetes mellitus.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khan_2019d, title = {Cardiac tamponade in the setting of a thymoma}, author = {Abdul K. Khan and Akriti G. Jain and Mohammed Faisaluddin and Neelam Khetpal and Jason D'Souza}, url = {https://www.cureus.com/articles/20398-cardiac-tamponade-in-the-setting-of-a-thymoma#!/authors}, doi = {10.7759/cureus.4952}, issn = {2168-8184}, year = {2019}, date = {2019-06-20}, urldate = {2019-06-01}, journal = {Cureus}, volume = {11}, issue = {6}, pages = {e4952}, publisher = {Cureus, Inc.}, abstract = {Thymoma is the most common neoplasm originating in the anterior mediastinum and accounts for a quarter of all mediastinal tumors. A pericardial effusion is an uncommon initial manifestation present in approximately 20% of patients. However, our patient had hemorrhagic pericardial effusions causing a cardiac tamponade with bilateral pleural effusions, nodular left pleural based masses, and ascites. In this report, we describe the unique features of our case and its management.}, key = {pmid31453026}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohan_2019b, title = {Effectiveness of dynamic hip screw in surgical management of trochantric fractures- a clinical study}, author = {Lalith Mohan and K. Vishnu}, url = {https://www.orthopaper.com/archives/2019/vol5issue3/PartJ/5-3-78-724.pdf}, doi = {10.22271/ortho.2019.v5.i3j.1590}, issn = {2395-1958}, year = {2019}, date = {2019-06-15}, urldate = {2019-06-15}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {3}, pages = {557-561}, abstract = {Introduction: Trochanteric fractures of femur has significant structural, clinical, anatomical and biochemical characteristics that distinguish them from intracapsular fractures. In past few decades, the treatment for intertrochanteric fractures has gained tremendous changes. The dynamic hip screw (DHS) development created a revolution in the management of unstable fractures of femur. Aims: To study the effectiveness of Dynamic HIP Screw in surgical management of Trochanteric fractures, to evaluate functional and anatomical outcome. Materials and Methods: The study consisted of 25 cases of Trochanteric Fractures treated surgically with Dynamic Hip Screw during the period of one and half years. The operative procedure which is commonly done for Trochanteric Fracture is Dynamic Hip Screw fixation the results were recorded and discussed. The average follow up period was for 6.64 months varying from 5 months to 1 ½ years. Results: Forty percent (10 patients) were less than 50 years age. Males outnumbered the females (19:6). Right-sided fractures outnumbered the left-sided (14:11). Fourteen out of twenty five patients were associated with severe violence. The younger age group patients were most often associated with severe violence (90%). The older age group patients were associated with trivial trauma (33%). Four out of the twenty-five patients (16%) were associated with other fractures. Type-I fracture had an excellent or a good result. 89% of Type-II fractures had an excellent or good result. 50% of Type-III and 57% of Type-IV fractures had a good result. Conclusions: Patients treated with this device have recovered early with painless hip movements, Hence Dynamic Hip Screw is an ideal implant for surgical management of Trochanteric Fractures. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2019, title = {Undifferentiated pleomorphic sarcomas of the proximal femur: A case study}, author = {Safa Fatima and Ahmad Muhammad and Juveria Khaleel}, url = {https://meddocsonline.org/journal-of-case-reports-and-medical-images/Undifferentiated-pleomorphic-sarcomas-of-the-proximal-femur-A-case-study.html}, doi = {10.33582/2639-9237/1017}, issn = {2639-9237}, year = {2019}, date = {2019-06-12}, urldate = {2019-06-12}, journal = {Journal of Case Reports and Medical Images}, volume = {2}, issue = {1}, pages = {1017}, abstract = {Pleomorphic sarcomas are a subtype of soft tissue sarcomas occurring most commonly in the proximal thigh, with a male preponderance, common in 7th and 8th decades of life. It is a locally invasive tumour with a wide clinical presentation. }, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Jain_2019, title = {Improving breast cancer screening rates in a primary care setting}, author = {Akriti G. Jain and Jian Guan and Mohammed Faisaluddin and Manoucher Manoucheri and Cheng Fang}, url = {https://onlinelibrary.wiley.com/doi/10.1111/tbj.13377}, doi = {10.1111/tbj.13377}, issn = {1075-122X}, year = {2019}, date = {2019-06-11}, urldate = {2019-06-01}, journal = {The Breast Journal}, volume = {25}, issue = {5}, pages = {963-966}, publisher = {Hindawi Limited}, abstract = {Biannual mammogram has been recommended for all women aged 50-74 years by USPSTF. Our aim was to improve the screening rates of biannual mammogram among women aged 50-74 years in a primary care clinic. Medical records were reviewed. Patients who were not up-to-date with their breast cancer screening, were contacted by telephone or a letter was sent. Our screening rate was found to be 64.7%. After 6 months, 38.5% had undergone mammograms after our intervention. This improved the compliance rate from 64.7% to 76.6%. Hence discussion of breast cancer screening status between a patient and provider can significantly increase compliance.}, key = {pmid31187549}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019b, title = {Role of guided growth in deformity correction around the knee using stevens 8 plate}, author = {Mohammed Jalal Mohiuddin and Lalith Mohan and Chavva Shamsunder and Aslam Mohsin and Sajid Salman}, url = {https://www.orthopaper.com/archives/2019/vol5issue3/PartI/5-3-70-926.pdf}, doi = {10.22271/ortho.2019.v5.i3i.1578}, issn = {2395-1958}, year = {2019}, date = {2019-06-10}, urldate = {2019-06-10}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {3}, pages = {505-507}, abstract = {Angular deformities of knee which includes genu varum, valgum, recurvate and procurator are common presentation in paediatric orthopaedics OPD. These are the developmental deforformites if attended on time can be managed with minimal invasive procedures (Hemi epiphysiodesis). The various methods described for epiphysiodesis and Stevens 8 plate assisted growth modulation is the best among them. Though Hemi epiphysiodesis correct the deformity over the period of time, it gives correction at CORA level without any complication. Timely done procedure can avoid need of invasive surgeries in future like corrective osteotomies.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Wazir_2019, title = {Idiopathic lateral rectus myositis without signs of orbital inflammation}, author = {Mohammed Wazir and Mohammed Faisaluddin and Daniel Tambunan and Akriti G. Jain}, url = {https://www.cureus.com/articles/20127-idiopathic-lateral-rectus-myositis-without-signs-of-orbital-inflammation#!/}, doi = {10.7759/cureus.4859}, issn = {2168-8184}, year = {2019}, date = {2019-06-07}, urldate = {2019-06-01}, journal = {Cureus}, volume = {11}, issue = {6}, pages = {e4859}, publisher = {Cureus, Inc.}, abstract = {Idiopathic orbital inflammation (IOI), also known as orbital pseudotumor, is a nonspecific term that represents inflammation of unknown etiology that could affect various orbital structures. We report a case of IOI with an atypical presentation mimicking other clinical conditions. Our patient did not show the typical signs of inflammation that are usually seen in patients with orbital pseudotumor and are paramount in its diagnosis. Hence the diagnosis of IOI should be considered in the differential diagnosis of periorbital pain even when clinical signs of orbital inflammation are absent.}, key = {pmid31410342}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019f, title = {Steroid-induced perilymphatic hypo pigmentation in orthopaedics practice}, author = {Mohammed Jalal Mohiuddin and Ramesh Bengaluri and Mirza Inzamam Ali Baig and Syed Abdul Tahreem and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2019/vol5issue3/PartI/5-3-63-951.pdf}, doi = {10.22271/ortho.2019.v5.i3i.1577}, issn = {2395-1958}, year = {2019}, date = {2019-06-06}, urldate = {2019-06-06}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {3}, pages = {503-504}, abstract = {Local steroid administration in form of injection or topical preparation is commonly used in various dermatological, orthopaedics and ophthalmological ailments. Intra-leisonal route of administration provides advantage of achieving high concentration locally without systemic adverse effects. Various indication in orthopaedics practice which need intralesional steroids are ganglion, Dequervian’s tenosynovitis, tennis and golfer’s elbow, Carpal Tunnel syndrome, Trigger finger Etc. Local adverse effects noted following this route of administration include dermal atrophy, ulceration, localized calcification, Hypo pigmentation etc. It seems to be dependent on certain factors such as concentration and potency of the drug being injected. The lesion is self-regressing and repigment by itself over the time. Topical application of various preparation helps in fastening the re-pigmentation process. Discussed are the 10 cases such lesion recovered completely. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Kehkashan_2019c, title = {Comparison of efficacy and safety of intravaginal dinoprostone (PGE2) gel and intracervical dinoprostone (PGE2) gel for cervical ripening and induction of labour at term}, author = {Anjum Kehkashan and Ismath Fatima}, url = {https://www.medpulse.in/Gynacology/Article/Volume10Issue2/OBGY_10_2_5.pdf}, doi = {10.26611/10121025}, issn = {2579-0870}, year = {2019}, date = {2019-05-31}, urldate = {2019-05-31}, journal = {MedPulse – International Journal of Gynaecology}, volume = {10}, issue = {2}, pages = {34-41}, abstract = {Background: Induction of labor is the stimulation of uterine contractions before the spontaneous onset of labor, with or without rupture membranes. Invention of prostaglandin preparation have revolutionized the methods of induction especially in unripe cervix and today, prostaglandins in various forms are used mainly for induction of labour with low Bishop’s score. Different preparations and different routes of administration of dinoprostone are used, for e.g. gels, tablets, pessaries, sustained release inserts. Material and methods: This prospective randomized control trial was carried out in the Department of Obstetrics and Gynecology at Princess Esra Hospital from 1/02/2017 till 30/07/2018 after obtaining permission from Institutional Ethics Committee. Accordingly 200 women who fulfilled inclusion/exclusion criteria and for induction of labour were enrolled in the study. These women were randomized into two groups, Group A and Group B. Observation and Results: With intracervical dinoprostone, early onset of labour pain was observed as compared to intravaginal dinoprostone gel. But at the end of 24 hours 99% in group A, 100% patients in group B started uterine contractions. With intracervical dinoprostone gel, active phase of labour was attained earlier as compared intravaginal route but, it was seen that at the end of 24 hours 88% in group A and 93% patient in group B went into active phase. The induction delivery interval was less with intracervical dinoprostone as compared to intravaginal dinoprostone. 63% women in group A and 61 % in group B delivered vaginally indicating effectivity of dinoprostone in vaginal delivery by both the groups. Conclusion: Intravaginal dinoprostone in the dose of 0.5 mg 8 hourly for induction of labour in unripe cervix should be considered as safe and effective method which is free of complication and has high success rate with minimal maternal and fetal morbidity. }, keywords = {Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Iftikhar_2019, title = {A challenging diagnosis of systemic lupus erythematosus with status epilepticus}, author = {Pulwasha M. Iftikhar and Maham Munawar and Choudhary A. Hasan and Mohammed Faisaluddin and Aly Cohen}, url = {https://www.cureus.com/articles/20233-a-challenging-diagnosis-of-systemic-lupus-erythematosus-with-status-epilepticus#!/}, doi = {10.7759/cureus.4783}, issn = {2168-8184}, year = {2019}, date = {2019-05-30}, urldate = {2019-05-01}, journal = {Cureus}, volume = {11}, issue = {5}, pages = {e4783}, publisher = {Cureus, Inc.}, abstract = {Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of unknown pathogenesis. In SLE, the body’s immune system mistakenly attacks healthy tissues and organs thereby involving multiple body systems including joints, skin, blood, brain, heart, and lungs. SLE has a wide variation in the symptoms, hence making the diagnosis more challenging at the time of initial presentation. Sometimes, the patient presents with Status epilepticus (SE) without prior history of epilepsy, as SE is common at the beginning in the course of SLE. In this report, there is a case showing correlation of seizures with SLE, without prior history of epilepsy. A 43-year-old female presented in the emergency department of the hospital with SE. Her previous medical and family history for epilepsy was unremarkable. The patient had high titers for positive anti-nuclear antibody (ANA), while other autoimmune workup was negative. A complete evaluation of the symptoms and investigations revealed that she met the criteria of American College of Rheumatology (ACR) for the diagnosis of SLE. Hence, physicians should be diligent with regards to the variations in the initial presentation and complications of SLE. With the advancement in treatment modalities of SLE, it can be managed successfully, if diagnosed early.}, key = {pmid31367501}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohammed_2019, title = {Atypical hemolytic uremic syndrome: a case report}, author = {Sohaib K. Mohammed and Ateeq Mubarik and Bilal Nadeem and Khudadad Khan and Salman Muddassir}, url = {https://www.cureus.com/articles/19800-atypical-hemolytic-uremic-syndrome-a-case-report#!/}, doi = {10.7759/cureus.4634}, issn = {2168-8184}, year = {2019}, date = {2019-05-10}, urldate = {2019-05-01}, journal = {Cureus}, volume = {11}, issue = {5}, pages = {e4634}, publisher = {Cureus, Inc.}, abstract = {Hemoytic uremic syndrome (HUS) is a rare type of thrombotic microangiopathies. Manifestations include thrombocytopenia, microangiopathic hemolytic anemia, and thrombi in small blood vessels. The prognosis is poor. Herein, we present a case of atypical HUS, which is very rare.}, key = {pmid31312560}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2019, title = {Intraperitoneal transplantation of bioengineered humanized liver grafts supports failing liver in acute condition}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Chandrakala Lakkireddy and Nagarapu Raju and Syed Ameer Basha Paspala and Md. Aejaz Habeeb and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/pii/S0928493117344946?via%3Dihub}, doi = {10.1016/j.msec.2019.01.045}, issn = {0928-4931}, year = {2019}, date = {2019-05-01}, urldate = {2019-05-01}, journal = {Materials Science and Engineering: C}, volume = {98}, pages = {861-873}, publisher = {Elsevier BV}, abstract = {Acute liver failure (ALF) is one of the most devastating fatal conditions which have posed crucial challenges to the clinicians and researchers for identifying permanent cure. Currently liver transplantation has been considered as the only managerial option. However it's wider applicability has been limited owing to non-availability of quality donor organs, cost-intensiveness, surgical hitches, life-long use of immunosuppressive drugs and long-term complications. Since last decades, several liver support systems have been developed for the management of failing liver in acute condition. However, the major limitation has been the lack of natural biological support and long-term survival of the grafts post-transplantation. Repopulation of decellularized xenogeneic organs is one of the emerging technologies for development of humanized neo-organs for demanding regenerative application. However, the earlier reported studies do not fulfil the insistence to provide immunologically tolerable humanized liver grafts for clinical applications. Here we demonstrate an efficient approach to generate transplantable humanized liver grafts which provides long-term support to the failing liver in Acute Liver Failure (ALF) animal models. These bioengineered humanized liver tissue grafts expresses several liver specific transcripts and performed crucial synthetic (albumin production) and detoxification (urea synthesis) functions at comparative level to normal liver. Intraperitoneal transplantation of these humanized liver grafts offered favourable microenvironment to exchange toxic substances across the barrier during ALF condition and provided long-term survival and function of the graft. In summary, the results of present study provide a first proof of concept in pre-clinical ALF animal model for the applicability of these bioengineered humanized livers in the management of failing liver on demand and may be considered as potential bridge to liver transplantation.}, key = {pmid30813092}, keywords = {Central Research Laboratory, Medical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Gurrala_2019, title = {A comparative study of efficacy of metroprolol and ivabradine in acute ST elevation myocardial infarction patients}, author = {Rajashekar Reddy Gurrala and Vinod K. Unni and Parvaiz Kadloor and T. K. Mohammed Rayees and Syed Azeemuddin Razvi and Syeda Uzma and Mehruq Fatima}, url = {https://www.msjonline.org/index.php/ijrms/article/view/6274/4711}, doi = {10.18203/2320-6012.ijrms20191671}, issn = {2320-6012}, year = {2019}, date = {2019-04-26}, urldate = {2019-04-26}, journal = {International Journal of Research in Medical Sciences}, volume = {7}, issue = {5}, pages = {1757-1761}, abstract = {Background: The ST-elevation myocardial infarction (STEMI), a fatal disease, is rapidly extending in patients, worldwide. Therefore, proper and timely diagnosis followed by appropriate management becomes necessary. The study aimed to compare the effectiveness of metoprolol and ivabradine in acute STEMI patients. Methods: This was an observational, comparative, in-hospital study carried out in patients admitted in the in-patient cardiac department, intensive cardiac care unit of a tertiary care centre in India. Total 60 patients diagnosed with acute ST-elevation MI were included in the study and were equally divided into two groups. Group 1 involved patients who were given metoprolol for treatment and group 2 involved patients who were given ivabradine. The patients were assessed in terms of heart rate, NYHA class, and ejection fraction. Follow-up of 30 days was taken in all patients. Results: Ivabradine reduced mean heart rate from 85.57 bpm at baseline to 78.23 bpm. Heart rate in the metoprolol group was reduced from 81.93 bpm to 76.47 bpm over the same time period. Metoprolol and ivabradine showed significant improvement in the ejection fraction volume during the in-hospitalization stay. Ivabradine showed a better improvement in ejection fraction when compared to metoprolol but the difference was not found to be statistically significant. Higher mortality was assessed in ivabradine group compared to metoprolol. Conclusions: The study gives the gold standard efficacy and mortality benefit of metoprolol, although ivabradine on the other hand gave better responses in heart rate reduction and improvements in ejection fraction.}, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2019b, title = {Engineering bio-mimetic humanized neurological constructs using acellularized scaffolds of cryopreserved meningeal tissues}, author = {Sandeep Kumar Vishwakarma and Chandrakala Lakkireddy and Avinash Bardia and Syed Ameer Basha Paspala and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/pii/S0928493118339328?via%3Dihub}, doi = {10.1016/j.msec.2019.04.028}, issn = {0928-4931}, year = {2019}, date = {2019-04-12}, urldate = {2019-09-01}, journal = {Materials Science and Engineering: C}, volume = {102}, pages = {34-44}, publisher = {Elsevier BV}, abstract = {Spinal cord injury (SCI) is one of the most precarious conditions which have been one of the major reasons for continuous increasing mortality rate of SCI patients. Currently, there is no effective treatment modality for SCI patients posing major threat to the scientific and medical community. The available strategies don't mimic with the natural processes of nervous tissues repair/regeneration and majority of the approaches may induce the additional fibrotic or immunological response at the injury site and are not readily available on demand. To overcome these hurdles, we have developed a ready to use bioengineered human functional neurological construct (BHNC) for regenerative applications in SCI defects. We used cryopreserved meningeal tissues (CMT) for bioengineering these neurological constructs using acellularization and repopulation technology. The technology adopted herein generates intact neurological scaffolds from CMT and retains several crucial structural, biochemical and mechanical cues to enhance the regenerative mechanisms. The neurogenic differentiation on CMT scaffolds was almost similar to the freshly prepared meningeal scaffolds and mimics with the natural nervous tissue developmental mechanisms which offer intact 3D-microarchitecture and hospitable microenvironment enriched with several crucial neurotrophins for long-term cell survival and function. Functional assessment of developed BHNC showed highly increased positive staining for pre-synaptic granules of Synapsis-1 along with MAP-2 antibody with punctuate distribution in axonal regions of the neuronal cells which was well supported by the gene expression analysis of functional transcripts. Given the significant improvement in the field may enable to generate more such ready to use functional BHNC for wider applicability in SCI repair/regeneration.}, key = {pmid31147006}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Khan_2019e, title = {A case report on traumatic avulsion fracture of greater trochanter ipsilateral and fixed with closed reduction and internal fixation with K-wires}, author = {Mazharuddin Ali Khan and Patlolla Karthik Reddy and Shaik Vazeer Uddin}, url = {https://www.ijsr.net/archive/v8i3/ART20196204.pdf}, issn = {2319-7064}, year = {2019}, date = {2019-03-31}, urldate = {2019-03-31}, journal = {International Journal of Science and Research}, volume = {8}, issue = {3}, pages = {974-976}, abstract = {Isolated greater trochanter fractures are uncommon. Isolated fractures of the greater trochanter are classified either astrue fractures, which occur solely in adults, or as epiphyseal separations, which are found in the adolescent population. It is reported that traumatic epiphyseal separations of the greater trochanter in adolescents are much more frequently encountered than true fractures in adults. It is generally accepted that these fractures are caused either by direct trauma over the trochanter, such as a blow, kick or fall, or by muscular violence, in which the bony fragment is avulsed from the trochanter.We present A case of 30 years male patient with traumatic avulsion fracture of greater trochanter associated with pelvic injury treated with closed reduction internal Fixation with k wires under C-Arm fluoroscopy guidance.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Akram_2019, title = {Comparison of biomarkers of neonatal sepsis: procalcitonin and c-reactive protein}, author = {Angadi Wasim Akram and Altaf Naseem}, url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/479/949}, doi = {10.17511/ijpr.2019.i03.06 }, issn = {2349-3267}, year = {2019}, date = {2019-03-31}, urldate = {2019-03-31}, journal = {Pediatric Review: International Journal of Pediatric Research}, volume = {6}, issue = {3}, pages = {134-143}, abstract = {Background: Procalcitonin in neonatal sepsis (NS) has high sensitivity compared to C-reactive protein (CRP), but its specificity is not yet clearly defined. Objectives: Evaluation of Procalcitonin as an early marker, assessing its diagnostic utility in early-onset NS was the primary and comparing the levels of Procalcitonin with CRP was secondary objective. Method: In this observational, prospective study, neonates meeting the selection criteria were included and grouped into three, according to clinical symptoms of sepsis and blood culture. Results: Blood samples from 75 babies (male = 61.0%) were analysed; 63.0% and 37.0% were of gestational age (GA) ≥ 37 and < 37 and weeks, respectively. Birth-weight< 2.5 kg and >2.5 Kg was noted in 52.0% and 48.0%, respectively. Meconium stained liquor (n=34), premature rupture of membranes (n=19) and prolonged labour/instrumental delivery (n=13) were major maternal risk factors.General (45.33%), respiratory (25.33%), gastrointestinal (17.33%), cardiovascular (6.66%)symptoms were common presentation; forty one (55.0%) were negative for procalcitonin and 34 (45.0%) were positive; 61 (81.0%) tested negative for CRP, only 14 (19.0%) were positive with levels >10mg/mL. Procalcitonin positivity was statistically significant (<0.05) for males, term babies and with normal birth weight favouring procalcitonin. of seven positive blood culture, coagulase positive staphylococci (n= 03), Klebsiella(n= 02), E. coli (n=01), Pseudomonas (n=01) were isolated. On correlation with blood culture, Procalcitonin showed better sensitivity and negative predictive value. Conclusion: Procalcitoninis a better early marker than CRP in early onset NS. It hasbetter positivity for male, term and normal birth weight babies.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Khan_2019b, title = {Report on traumatic avulsion fracture of greater trochanter ipsilateral and fixed with closed reduction and internal fixation with K-wires}, author = {Mazharuddin Ali Khan and Patlolla Karthik Reddy and Shaik Vazeer Uddin}, url = {https://www.ijsr.net/archive/v8i3/ART20196204.pdf}, issn = {2319-7064}, year = {2019}, date = {2019-03-31}, urldate = {2019-03-31}, journal = {International Journal of Science and Research}, volume = {8}, issue = {3}, pages = {974-976}, abstract = {Isolated greater trochanter fractures are uncommon. [1]Isolated fractures of the greater trochanter are classified either as true fractures, which occur solely in adults, or as epiphyseal separations, which are found in the adolescent population. [2] It is reported that traumatic epiphyseal separations of the greater trochanter in adolescents are much more frequently encountered than true fractures in adults. [3] It is generally accepted that these fractures are caused either by direct trauma over the trochanter, such as a blow, kick or fall, or by muscular violence, in which the bony fragment is avulsed from the trochanter.We present A case of 30 years male patient with traumatic avulsion fracture of greater trochanter associated with pelvic injury treated with closed reduction internal Fixation with k wires under C-Arm fluoroscopy guidance. }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Sharma_2019, title = {Consensus on the management of posterior urethral valves from antenatal period to puberty}, author = {Shilpa Sharma and Manoj Joshi and Devendra K. Gupta and Mohan Abraham and Praveen Mathur and J. K. Mahajan and A. N. Gangopadhyay and Simmi K. Rattan and Ravindra Vora and G. Raghavendra Prasad and N. C. Bhattacharya and Ram Samuj and K. L. N. Rao and A. K. Basu}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322183/?report=reader}, doi = {10.4103/jiaps.JIAPS_148_18}, issn = {0971-9261}, year = {2019}, date = {2019-03-31}, urldate = {2019-03-31}, journal = {Journal of Indian Association of Pediatric Surgeons}, volume = {24}, issue = {1}, pages = {4-14}, abstract = {The need for successful management of posterior urethral valves always captivates the minds of pediatric surgeons. Its success, however, depends on several factors ranging from prenatal preservation of upper tracts to postoperative pharmacological compliance. Regardless of measures available, some cases do not respond and progress to end stage. The management depends on several issues ranging from age and severity at presentation to long-term follow-up and prevention of secondary renal damage and managing valve bladder syndrome. This article is based on a consensus to the set of questionnaires, prepared by research section of Indian Association of Paediatric Surgeons and discussed by experienced pediatric surgeons based in different institutions in the country. Standard operating procedures for conducting a voiding cystourethrogram and cystoscopy were formulated. Age-wise contrast dosage was calculated for ready reference. Current evidence from literature was also reviewed and included to complete the topic.}, keywords = {General Surgery, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2019, title = {Effects of cigarette smoking on erythrocyte sedimentation rate, platelet count, total and differential leucocyte counts in adult male smokers}, author = {Safia Sultana and Nabila Afsar and Mohammed Jawad and Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v3i1.35185}, doi = {10.23921/amp.2019v3i1.35185}, issn = {2456-8422}, year = {2019}, date = {2019-03-28}, urldate = {2019-03-28}, journal = {Annals of Medical Physiology}, volume = {3}, issue = {1}, pages = {14-18}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, abstract = {Smoking is one of the leading causes of death worldwide. Smokers have higher risk for coronary heart disease, atherosclerosis, acute myocardial infarction, hypertension, clotting disorders, inflammation, respiratory diseases, cancers, etc. A cigarette smoker is exposed to a number of harmful substances. In this study we hypothesized that smoking causes inflammatory reactions and induces hyperthrombic state in the body which may be reflected in erythrocyte sedimentation rate (ESR), total leucocyte count (TLC), differential leucocyte count (DLC) and platelet count values. The purpose of the study was to study the effects of cigarette smoking on erythrocyte sedimentation rate, total leucocyte count and platelet count in adult male smokers and to compare the results with non-smokers and to establish a relationship between the duration and quantity of smoking with the change in ESR, TLC, DLC and platelet count. A cross sectional study was conducted in the department of Pathology on 86 healthy male subjects (smokers=43 and non-smokers=43). ESR was estimated using Westergrens method. TLC, DLC and platelet counts were estimated using HORIBA Pentra ES60 autoanalyser. TLC and basophil counts were significantly higher in smokers than in non-smokers (p<0.05). The mean value of ESR was higher among smokers than non-smokers but it was statistically insignificant. Platelets counts showed no significant difference between smokers and non- smokers. No correlation was observed in various blood parameters and smoking (in pack years). We conclude that smoking initiates an inflammatory response as evidenced from raised TLC, monocyte and basophil counts.}, keywords = {Pathology, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2019b, title = {Failing immune surveillance in humans: Repercussion of modern day lifestyles}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v3i1.38529}, doi = {10.23921/amp.2019v3i1.38529}, issn = {2456-8422}, year = {2019}, date = {2019-03-27}, urldate = {2019-03-27}, journal = {Annals of Medical Physiology}, volume = {3}, issue = {1}, pages = {1-2}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Lodhi_2019b, title = {Glycemic control with four way model approach in rural area patients}, author = {Mohammed Mansoor Ali Khan Lodhi}, url = {https://www.msjonline.org/index.php/ijrms/article/view/6040/4580}, doi = {10.18203/2320-6012.ijrms20191298}, issn = {2320-6012}, year = {2019}, date = {2019-03-27}, urldate = {2019-03-27}, journal = {International Journal of Research in Medical Sciences}, volume = {7}, issue = {4}, pages = {977-981}, abstract = {Background: It is very important to keep the Glucose levels under control continuously and without any holidays. Type 2 diabetes is increasingly common in the industrialized world. Tight glycemic control attempts to rigidly glucose control levels (A1c: 6.5% -7.0% or lower). Maintaining tight glycemic control is lifesaving. Proper counselling, proper nutrition and if regular exercise is done it can result is good glycemic control. Methods: In the present study a total of 350 diabetic patients were selected out of which only 208 participants were eligible for study. Inclusion criteria in the study were 1) Age: men and women between age group 30 years to 70 years and 2) Type 2 Diabetes mellitus with HbA1c between 8 to 10%. Exclusion criteria in the study were 1) Type 1diabetes mellitus, Pre-existing renal, hepatic or cardiac disease, Hba1c >10%. A quadriad was established between patients, personal health worker, dietician and doctor. Results: Participants had regularly followed up and were divided randomly into cases (n = 112) and controls (n = 96). Patient were followed up as per study design it was observed that at the end of 3 months period mean FBS (case group 168.2±26.4 control group 200.8±38.3 p value <0.001) , Mean PPBS (case group 204.8±53.0 control group 271.0±45.5 p value <0.001) and Mean Hba1c (case group 8.7±0.5 control group 8.9±0.6 p value .003) in cases was significantly lower than control group.at the end 6 months it was observed that the mean cholesterol, mean triglyceride, mean LDL and mean VLDL was significantly lower in the cases compared to controls. Conclusions: A systematic approach and close monitoring that increased the adherence to medication, diet, and counselling would help in better glycemic control and prevent long term complication.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Jain_2019b, title = {Plasma cell leukemia - one in a million: a case report}, author = {Akriti G. Jain and Mohammed Faisaluddin and Abdul K. Khan and Mohammed Wazir and Qi Shen and Manoucher Manoucheri}, url = {https://f6publishing.blob.core.windows.net/142d1f87-cf34-4aab-b74e-db57e59a72ce/WJCO-10-161.pdf}, doi = {10.5306/wjco.v10.i3.161}, issn = {2218-4333}, year = {2019}, date = {2019-03-24}, urldate = {2019-03-01}, journal = {World Journal of Clinical Oncology}, volume = {10}, issue = {3}, pages = {161-165}, publisher = {Baishideng Publishing Group Inc.}, abstract = {BACKGROUND: Plasma cell leukemia (PCL) is diagnosed by the presence of an absolute plasma cell count of > 2 × 109/L or 20% plasma cells in the peripheral blood. Because the incidence of PCL is relatively low, our case report study presents a rare opportunity to describe the clinical and pathological characteristics of this leukemia, as well as different modalities of treatment and outcomes of primary PCL (pPCL). CASE SUMMARY: A 56-year-old male with a history of hypertension complained of pain in the left flank area which started four months prior to admission. On admission, his vital signs were stable, and physical examination was completely benign. Laboratory evaluation showed hemoglobin of 5.1 g/dL, white blood cell count of 6.6 cells per cubic millimeter with 16% atypical lymphocytes, and platelet count of 51000 per microliter. Peripheral smear showed more than 10%-15% of plasma cells (Figure 1), and flow cytometry of peripheral blood confirmed PCL with 24% plasma cells CD138+. Bone marrow biopsy demonstrated 80% plasma cells (38+, 138+, 117+, 10-, 19-, 20-, 56-) with 90% cellularity. The Oncology team was consulted, and VCD therapy was started. After completing therapy at 1, 4, 8, and 11 d, the patient was discharged home. The patient was being considered for a bone marrow transplant evaluation within two months of discharge. CONCLUSION: PCL is a rare and aggressive form of leukemia with a poor prognosis. Multi-center studies and clinical trials should be conducted to develop accurate criteria for the initial diagnosis and prompt treatment of this disease.}, key = {pmid30949445}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Afsar_2019, title = {Young immunocompetent individual positive for histoplasma capsulatum on bronchoalveolar lavage fluid cytology}, author = {Nabila Afsar and Maseera Zareen and Idrees Akhtar Afroze and Atiya Begum}, url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2348/1690}, doi = {10.21276/APALM.2348}, issn = {2349-6983}, year = {2019}, date = {2019-03-16}, urldate = {2019-03-16}, journal = {Annals of Pathology and Laboratory Medicine}, volume = {6}, issue = {3}, pages = {C37-C39}, abstract = {Primary pulmonary histoplasmosis is a lung disease caused by dimorphic fungus Histoplasma Capsulatum. Bronchoalveolar fluid cytology is routinely performed as an inexpensive test even in under equipped laboratories. A 26 year old female, presented with persistent cough, evening rise of temperature and generalised weakness since 3 months and streaky hemoptysis since 3 weeks. CT showed consolidation in lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal cultures and antigen testing. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Farooqui_2019, title = {Role and significance of hematological parameters in diabetes mellitus}, author = {Rafae Farooqui and Nabila Afsar and Idrees Akhtar Afroze}, url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2355/1687}, doi = {0.21276/APALM.2355}, issn = {2349-6483}, year = {2019}, date = {2019-03-16}, urldate = {2019-03-16}, journal = {Annals of Pathology and Laboratory Medicine}, volume = {6}, issue = {3}, pages = {A158-A162}, abstract = {Background: Diabetes mellitus is a global metabolic disorder characterized by persistent hyperglycemia and increased risk of microvascular and macrovascular complications. Consistent elevation of HbA1c can be associated with functional and structural changes in hemoglobin molecule, cytoplasmic viscosity and osmotic disturbances within red cell. These changes may be reflected in the red cell analytical parameters. Methods: 120 subjects were studied. 41 were non diabetic healthy subjects (Group1). 79 were known diabetic patients, divided into two groups: HbA1c <7(39 subjects) Group 2 and HbA1c >7(40 subjects) Group 3. Sample for glucose estimation and CBC were collected in vacutainers containing sodium Fluoride and K 2EDTA respectively. Glucose, HbA1c and CBC estimation was carried out by auto analyzers. Result: Mean RBC count of diabetics with HbA1c<7 was less when compared to non-diabetic individuals. Significant decrease was noted in the mean RBC count, Hb, HCT and MCV of diabetics with HbA1c>7 when compared to non diabetic individuals. There was significant decrease in mean Hb, HCT, MCV, MCH of diabetics with HbA1c >7 when compared to diabetics with HbA1c <7. Conclusion: The findings in the present study suggest that diabetic patients with poor control are more prone to develop anemia. This indicates a need for routine CBP examination for early detection and management of anemia in diabetic patients at the primary care setting to reduce associated morbidity due to lowered immunity associated with anemia and complications such as diabetic ketoacidosis.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019, title = {Ultra sound assisted calculation of rotational malalignment in supracondylar humerus fracture in pediatrics: comparison with clinical assessment and its reliability}, author = {Mohammed Jalal Mohiuddin and Hassan Rafeeq and Shaik Vazeer Uddin and Chavva Shamsunder and K. Mrudula}, url = {https://www.orthopaper.com/archives/2019/vol5issue2/PartI/5-1-101-499.pdf}, doi = {10.22271/ortho.2019.v5.i2i.63}, issn = {2395-1958}, year = {2019}, date = {2019-03-15}, urldate = {2019-03-15}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {2}, pages = {633-635}, abstract = {Supra condylar Humerus fracture are the commonest elbow injury in children, constitute 70 – 80 percent. There are three dimensional displacements which include coronal, sagital and rotational planes. Coronal and sagital malalignment can easily calculated by cortical alignments, anterior humeral line, Baumann’s angle, metaphyseo diaphyseal angle. For measuring rotational malalignment we need to rely either clinically or on CT scan (cost and radiation). Ultrasound assisted method is non invasive, cost effective and reproducible. Present study is the assessment of rotational Malunion of Humerus in Supracondylar fracture based on ultrasound calculations in 10 patients and comparison with their contra lateral normal Humerus.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019d, title = {Genu valgum correction by distal femoral lateral open wedge corrective osteotomy}, author = {Mohammed Jalal Mohiuddin and Hassan Rafeeq and K. Mrudula and Aslam Mohsin and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2019/vol5issue2/PartG/5-1-140-323.pdf}, doi = {10.22271/ortho.2019.v5.i2g.45}, issn = {2395-1958}, year = {2019}, date = {2019-03-15}, urldate = {2019-03-15}, journal = {International Journal of Orthopaedics Sciences}, volume = {5}, issue = {2}, pages = {344-346}, abstract = {There are various conditions which effects normal growth of the physis. As femoral and tibial physis have maximum growth potential, any such diseases affects them most. Genu valgum is one such condition in which distal femur is commonly effected. The various etiologies are idiopathic, rickets, trauma, infections etc. The genu valgum is not only the cosmetic deformity but also alters biomechanics of knee and predispose knee to early lateral compartment osteoarthritis. After popularization of Steven’s 8 plate assisted growth modulation, the need of corrective osteotomy has declined considerably. For the mature skeleton corrective osteotomy is the only answer for correction. The level of osteotomy which is either metaphyseal or metadiaphyseal and the use of bone graft is merely the surgeon’s choice. The effect of acute correction over the lateral neurovascular bundle is not being studied clearly. Present study is the correction of genu valgum involving femoral component by distal femoral lateral based open wedge osteototomy without bone graft. The subclinical effect of osteotomy over the Common Peroneal nerve measured. The correction achieved, time required for the union of bone etc also documented.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2019c, title = {Surgical correction of post traumatic cubitus varus deformity using Vellore technique}, author = {Mohammed Jalal Mohiuddin and Wasif Ishaqui and Shaik Vazeer Uddin}, url = {https://www.journalijar.com/uploads/715_IJAR-26547.pdf}, doi = {10.21474/IJAR01/8685}, issn = {2320-5407}, year = {2019}, date = {2019-03-08}, urldate = {2019-03-08}, journal = {International Journal of Advanced Research}, volume = {7}, issue = {3}, pages = {664-668}, abstract = {Malunion of Supracondylar fractures of the Humerus resulting in CubitusVarus is a common complication in our country. It needs correction not only for the cosmetic deformity but also for the other reasons which include increased incidence of posterior-lateral elbow instability, lateral condyle fracture, ulnar nerve friction neuropraxia and shoulder dislocation if not corrected. Many methods have been described but the correction commonly done now is by modified French osteotomy. There are various techniques for modified French osteotomy, but the described Vellore technique do correction at lower level nearest to the CORA, which is ideal. Described is the case which was corrected using Vellore technique.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Saini_2019, title = {Anatomical multiple variations of coronary arteries in human hearts - A cadaveric study from Rajasthan}, author = {Neha Saini and Vasanta Leela and Dhiraj Saxena}, url = {https://ijrar.org/viewfull.php?&p_id=IJRAR19H1067}, issn = {2348-1269}, year = {2019}, date = {2019-03-01}, journal = {International Journal of Research and Analytical Reviews}, volume = {6}, issue = {1}, pages = {424-428}, abstract = {Introduction: Coronary artery disease is one of the major causes of death in developed as well as developing countries. The increasing use of diagnostic and therapeutic interventional procedures necessitates that a sound, basic knowledge of the coronary artery pattern is essential. Materials & Methods: The present study was undertaken in the Department of Anatomy, SMS Medical College included 50 cadaveric human hearts. After simple dissecting procedure coronary arteries were traced and their variations were noted. Results- Right coronary artery was originating from right anterior aortic sinus in 94% of the total human hearts and in 3% cases from left anterior aortic sinus. It terminates at the point between right border-crux in 80% cases. The left coronary artery bifurcated in 64% cases also, quadrifurcation was observed in 10% of hearts. It gets terminated at anterior apex in 68%, and in 6% cases it reaches upto > 5 cms up in the posterior interventricular sulcus. Conclusion: The precise knowledge of coronary arteries is required for the angiographers and cardiothoracic surgeons for an efficient management of coronary disease and other cardiac ailments.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Khan_2019c, title = {A rarest presentation of chondromyxoid fibroma in proximal ulna}, author = {Mazharuddin Ali Khan and Patlolla Karthik Reddy and Shaik Feroz Ahmed}, url = {https://www.ijsr.net/archive/v8i2/4021901.pdf}, issn = {2319-7064}, year = {2019}, date = {2019-02-28}, urldate = {2019-02-28}, journal = {International Journal of Science and Research}, volume = {8}, issue = {2}, pages = {543-547}, abstract = {Chondromyxoid fibroma (CMF)is one of rarest benign tumours of cartilaginous origin. It accounts for less than 0.5% of bone tumours and less than 2% of benign tumours. It mainly affects the metaphysis of long bones of lower extremity, the proximal tibia, distal Femur being the most common location and rare in upper extremity (ulna bone). After taking informed consent from patient for this study, we present a case of chondromyxoid fibroma in a 12 year old female involving right proximal end of ulna which was treated with En bloc Excision and filling with bone grafting (PMMA) With excellent result on Follow up.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Iftikhar_2019b, title = {A bibliometric analysis of the top 30 most-cited articles in gestational diabetes mellitus literature (1946-2019)}, author = {Pulwasha M. Iftikhar and Fatima Ali and Mohammed Faisaluddin and Azadeh Khayyat and Maribel De Gouvia De Sa and Tanushree Rao}, url = {https://www.cureus.com/articles/17363-a-bibliometric-analysis-of-the-top-30-most-cited-articles-in-gestational-diabetes-mellitus-literature-1946-2019#!/}, doi = {10.7759/cureus.4131}, issn = {2168-8184}, year = {2019}, date = {2019-02-25}, urldate = {2019-02-01}, journal = {Cureus}, volume = {11}, issue = {2}, pages = {e4131}, publisher = {Cureus, Inc.}, abstract = {Objective: The aim of this bibliometric analysis is to evaluate the importance and impact of the articles that have been published with the title gestational diabetes mellitus (GDM) in the specialty of obstetrics & gynecology and endocrinology during the period 1946-2019. It also reveals that the area of GDM has received increased attention and interest by researchers, research funding institutions, and practitioners. Material and methods: A thorough database search of Scopus and Web of Science was performed and the articles pertaining to gestational diabetes mellitus that were published between 1946 and 2019 were reviewed by two reviewers, Iftikhar PM and Ali F, with respect to their year of publication, authors, country of origin, journal of publication, and the affiliated institutions of the authors as well as journals. Institutional review board approval was not required for this study, as the data being analyzed were already available electronically, and otherwise, in libraries and databases. Results: The 30 most-cited articles on gestational diabetes mellitus were thoroughly analyzed. The top article was cited 5028 times while the least number of citations for any article was 328. Among these 30 articles, five were published in the year 2005, which is the highest number of publications in any given year of the timeline being considered in this study. Most of the articles (n = 18) were from the United States of America, followed by Australia (n = 3); other countries contributed to two or fewer articles. Diabetes Care made most (n = 8) of the list. We found one author who had three publications and the rest contributed two or less articles. The top article in our study was cited almost 5028 times; meanwhile, there are 13 journals from different specialties that have referenced the most cited articles pertaining to gestational diabetes. Conclusion: Our bibliometric analysis provides a picture of scientific research, which will help in evidence-based descriptions, comparisons, and visualizations of research output in GDM, and it can be used to explicate and describe the patterns of performance and impact of GDM research.}, key = {pmid31058014}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Fathima_2019, title = {Association and gene–gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease}, author = {Nusrath Fathima and Parimala Narne and Mohammed Ishaq}, url = {https://link.springer.com/article/10.1007/s12020-019-01859-3}, doi = {10.1007/s12020-019-01859-3}, issn = {1559-0100}, year = {2019}, date = {2019-02-15}, urldate = {2019-02-01}, journal = {Endocrine}, volume = {64}, issue = {3}, pages = {591-604}, publisher = {Springer Science and Business Media LLC}, abstract = {Purpose: Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) in South-Indian population. Methods: A total of 355 AITD subjects (comprising 275 HT and 80 GD) and 285 randomly selected age- and sex-matched control subjects were genotyped for the aforementioned polymorphisms by PCR-RFLP method. Results: The rs231775 “G” allele was preponderant in HT and GD subjects when compared with controls and exerted a dominant influence on the susceptibility to HT (p = 0.009) and GD (p = 0.02), respectively. There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549. Haplotype analysis revealed an increased frequency of rs3761548 “C”–rs3761549 “T” in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03). Epistatic interaction analysis by multifactor dimensionality reduction approach revealed redundancy between CTLA-4 and FOXP3 genes in influencing the susceptibility to AITD. Conclusions: The genetic variation in CTLA-4 gene with reference to rs231775 polymorphism contributes to an increased predisposition to HT and GD. Also, in conjunction with FOXP3 gene variants it seems to influence the susceptibility to HT and GD respectively. The significance of these findings in combination with antithyroid antibody screening could plausibly contribute towards meticulous case-finding for effective treatment of HT and GD.}, key = {pmid30771152}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Seethamsetty_2019, title = {A comparative evaluation of the effectiveness of chitosan-based dressing and conventional method of hemostasis in patients on oral antithrombotic therapy without therapy interruption}, author = {Swetcha Seethamsetty and Godvine Sarepally and Arshiya Sanober and Yousuf Qureshi and Umayra Fatima and Shaik Mohammed Arif}, url = {https://journals.lww.com/jpbs/fulltext/2019/11001/a_comparative_evaluation_of_the_effectiveness_of.3.aspx}, doi = {10.4103/jpbs.jpbs_229_18}, issn = {0975-7406}, year = {2019}, date = {2019-02-01}, urldate = {2019-01-01}, journal = {Journal of Pharmacy & BioAllied Sciences}, volume = {11}, issue = {5}, pages = {S18-S23}, publisher = {Medknow}, abstract = {Aims and Objectives: To assess the effectiveness of chitosan-based dressing after extraction in individuals on antithrombotics, without modification of their treatment schedule. Materials and Methods: A randomized comparative study was carried out on 40 subjects who had two extraction sites, in dissimilar quadrants. The surgical site was chosen at random and post-extraction hemostasis was achieved by a custom-cut chitosan dressing (study site) and sterile cotton gauze dressing (suturing if required) at control site. Patients were reviewed on the first, third, fifth, and seventh postoperative days and every week till 4 weeks. The parameters assessed were timing of hemostasis, pain scores, and pus discharge. Results: Out of 40 study subjects, 24 (60%) were males and 16 (40%) were females. The age was 40–65 years (mean age 54 years). The mean time for hemostasis was 0.63 ± 0.27 min in study group, whereas for controls, it was 9.10 ± 2.28 min. The difference in postoperative pain was significant (P = 0.001) on days one, five, and seven. In chitosan group extraction sites, dry socket was not seen, whereas four patients on day three and five patients on day five after extraction experienced dry socket in pressure gauze dressings group, with an insignificant difference (P = 0.058). In chitosan group extraction sites, no pus discharge was seen. Whereas four patients on days three and five after extraction had pus discharge in patients where pressure dressings were applied, with an insignificant difference (P = 0.058). Conclusion: Chitosan dressing is a competent hemostatic agent that significantly reduced the post-extraction bleeding, with better pain control. Chitosan group had no incidences of dry socket and pus discharge.}, key = {pmid30923426}, keywords = {Dentistry}, pubstate = {published}, tppubtype = {article} } @article{Faisaluddin_2019b, title = {Etripamil: self-management of supraventricular tachycardia is not far away?}, author = {Mohammed Faisaluddin and Kumar Ashish and Adrija Hajra and Samhati Mondal and Dhrubajyoti Bandyopadhyay}, url = {https://www.sciencedirect.com/science/article/pii/S2352906718301829?via%3Dihub}, doi = {10.1016/j.ijcha.2018.12.007}, issn = {2352-9067}, year = {2019}, date = {2019-01-04}, urldate = {2019-03-01}, journal = {IJC Heart & Vasculature}, volume = {22}, pages = {82-83}, publisher = {Elsevier BV}, key = {pmid30627628}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Naz_2019, title = {Activation of integrated stress response pathway regulates IL-1β production through posttranscriptional and translational reprogramming in macrophages}, author = {Saima Naz and Srikanth Battu and Rafiq Ahmad Khan and Sumbul Afroz and Jeevan Giddaluru and Sandeep Kumar Vishwakarma and Vishnupriya Satti and Md. Aejaz Habeeb and Aleem Ahmed Khan and Nooruddin Khan}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.201847513}, doi = {10.1002/eji.201847513}, issn = {0014-2980}, year = {2019}, date = {2019-01-01}, urldate = {2019-01-01}, journal = {European Journal of Immunology}, volume = {49}, issue = {2}, pages = {277-289}, publisher = {Wiley}, abstract = {Immune cells sense and programme its cellular machinery appropriately to the environmental changes through the activation of cytoprotective adaptive pathway so-called the “integrated stress response (ISR)”. However, the mechanisms implicated in ISR-induced protective responses are poorly understood. Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1β production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism. Ar triggers PTR events through eIF2α-phosphorylation, which results in the attenuation of active polysome formation leading to the accumulation of translationally stalled IL-1β mRNAs. Translationally stalled IL-1β mRNAs recruit RNA-binding proteins (TIA-1/TIAR), resulting in the formation of RBP-RNA complexes known as stress granules (SGs). The SGs bound IL-1β mRNAs might undergo degradation through induction of autophagy. Also, we show that Ar posttranslationally impairs processing and secretion of IL-1β by diminishing inflammasome activation. Altogether, this study unveils a novel mechanism of IL-1β regulation and further suggests that pharmacological activation of cytoprotective ISR pathway might provide an effective therapeutic intervention against inflammatory diseases.}, key = {pmid30578631}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Vanka_2019, title = {Osteo/odontogenic differentiation of human mesenchymal stem cells with platelet-rich plasma and mineral trioxide aggregate}, author = {Shanthi Vanka and Amit Vanka and Sandeep Kumar Vishwakarma and Manohar K. Bhat and Othman Wali and Aleem Ahmed Khan}, url = {https://www.thejcdp.com/doi/pdf/10.5005/jp-journals-10024-2677}, doi = {10.5005/jp-journals-10024-2677}, issn = {1526-3711}, year = {2019}, date = {2019-01-01}, urldate = {2019-01-01}, journal = {The Journal of Contemporary Dental Practice}, volume = {20}, issue = {10}, pages = {1171-1178}, publisher = {Jaypee Brothers Medical Publishing}, abstract = {Aim: Aim of the study was to investigate the effect of PRP and MTA individually and combined on in vitro human bone marrow mesenchymal stem cells’ (MSCs) proliferation and osteo/odontogenic differentiation potential. Materials and methods: MSCs were cultured in vitro with MTA, 5% PRP, 10% PRP, MTA with 5%PRP, and MTA with 10% PRP. Fetal calf serum (FCS) was used as control. Cell viability and proliferative efficiency were tested with cell adhesion and MTT assay. Osteo/odontogenic differentiation was assessed and quantified with alizarin red staining. Results: MTA alone, MTA with 5% PRP, and MTA with 10% PRP showed significantly high proliferation at day 7 and 14 when compared to the control group. Enhanced differentiation and the highest calcium deposition was observed in MTA with the 10% PRP group. Conclusion: Within limitations of the in vitro environment, results imply an increased proliferation and induction of MSCs into osteo/odontogenic differentiation by the combination rather than a mere sealing of PRP by MTA. Clinical significance: PRP and MTA have the potential for true regeneration of the pulp tissue. Moreover, the combination of PRP and MTA can be utilized to expand the MSCs to generate adequate numbers for clinical applications, without xenogenic contamination.}, key = {pmid31883252}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @inbook{Haneef_2019, title = {Code of medical ethics}, author = {Putta Srinivas and Nayeem Sadath Haneef }, editor = {Venkataram Mysore and Satish Bhat and Subodh Premanand Sirur}, doi = {10.5005/jp/books/18187_4}, isbn = {9789352708970}, year = {2019}, date = {2019-01-01}, booktitle = {Medico-legal aspects of dermatology and plastic surgery}, pages = {22-37}, publisher = {Jaypee Brothers Medical Publishers (P) Ltd}, address = {New Delhi}, edition = {1st}, chapter = {3}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {inbook} } @article{Arifuddin_2018, title = {Blood group reckoning: Unraveling the mystery of blood group antigens}, author = {Mehnaaz Sameera Arifuddin}, url = {https://amphysiol.com/index.php/amp/article/view/v2i4.23002}, doi = {10.23921/amp.2018v2i4.23002}, issn = {2456-8422}, year = {2018}, date = {2018-12-31}, urldate = {2018-12-31}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {4}, pages = {33-35}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018f, title = {Late presentation of irreducible complex dorsal dislocation of the metacarpophalangeal joint of the thumb-a case report}, author = {Mazharuddin Ali Khan and Patlolla Karthik Reddy and Shaik Vazeer Uddin}, url = {https://www.journalijar.com/uploads/353_IJAR-25790.pdf}, doi = {10.21474/IJAR01/8287}, issn = {2320-5407}, year = {2018}, date = {2018-12-22}, urldate = {2018-12-22}, journal = {International Journal of Advanced Research}, volume = {6}, issue = {12}, pages = {1444-1447}, abstract = {Dorsal dislocation of the metacarpophalangeal joint of the thumb is uncommon.complex dislocations occur most commonly in index finger followed in incidence by thumb & small finger &, rarely, long & ring fingers.Complex dislocations are described as dislocations that are irreducible ,infolding of the proximally disrupted volar plate between metacarpal head and base of proximal phalanxand often require surgical intervention because the thumb MP joint, anatomical structures that may become entrapped include the volar plate, sesamoid bones, bony fracture fragments or the flexor pollicislongus tendon. A case report on the post traumatic , complete complex dorsal dislocation the thumb is surgically treated on volar approach is presented.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Jain_2018, title = {A rare case of crohn's disease manifesting as a large liver abscess}, author = {Akriti G. Jain and Mohammed Faisaluddin and Idljona Gllava and Dwayne Gordon and Jian Guan}, url = {https://www.cureus.com/articles/16580-a-rare-case-of-crohns-disease-manifesting-as-a-large-liver-abscess#!/}, doi = {10.7759/cureus.3758}, issn = {2168-8184}, year = {2018}, date = {2018-12-21}, urldate = {2018-12-01}, journal = {Cureus}, volume = {10}, issue = {12}, pages = {e3758 }, publisher = {Cureus, Inc.}, abstract = {Liver abscess is a rare complication seen in Crohn's disease (CD) and has been rarely reported. Our aim is to illustrate a case of liver abscess in a patient with CD and the importance of a complete history and physical examination in identifying the potential cause of a hepatic abscess in an immune competent individual in who the diagnosis of CD was apparently ignored for two years before she presented to us. Although the manifestation of a hepatic abscess without any perianal abscess or fistula in CD is extremely rare, recognition of this would facilitate the diagnosis and appropriate management of abscess and CD.}, key = {pmid30820378}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohiuddin_2018, title = {Brachial plexus injury: following birthday bumps}, author = {Mohammed Jalal Mohiuddin and Mohammed Wajid Hussain and Umaid Mirza}, url = {https://www.joas.in/temp/JOrthopAlliedSci6286-2748498_073804.pdf}, doi = {10.4103/joas.joas_23_18}, issn = {2666-7150}, year = {2018}, date = {2018-12-19}, urldate = {2018-12-19}, journal = {Journal of Orthopedics and Allied Sciences}, volume = {6}, issue = {2}, pages = {86-88}, abstract = {Fractures and blunt Injuries following birthday bumps are reported in literature, but to the best of our knowledge, brachial plexus injuries following birthday bumps have not been. Reported is one such case which was managed conservatively. The neuro deficit recovered completely over the course of time. Teenagers especially college and hostel students may hide the mechanism of injury, and it may distract the physician from arriving at proper diagnosis. To avoid similar injuries in future, it needs counseling and proper adolescence care.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Ashish_2018, title = {Prognostic value of global longitudinal strain in heart failure subjects: a recent prototype}, author = {Kumar Ashish and Mohammed Faisaluddin and Dhrubajyoti Bandyopadhyay and Adrija Hajra and Eyal Herzog}, url = {https://www.sciencedirect.com/science/article/pii/S2352906718301398?via%3Dihub}, doi = {10.1016/j.ijcha.2018.11.009}, issn = {2352-9067}, year = {2018}, date = {2018-12-13}, urldate = {2019-03-01}, journal = {IJC Heart & Vasculature}, volume = {22}, pages = {48-49}, publisher = {Elsevier BV}, abstract = {Heart failure (HF) is one of the most debilitating, highly prevalent medical condition requiring frequent hospitalization impairing the quality of life and impart huge cost burden. The pathophysiology of HF is complex. Various research works are going on to find out the correlation between different factors behind the pathogenesis and prognosis of HF [1]. Global longitudinal strain (GLS) is a newly emerging topic which has a significant role in predicting cardiovascular outcomes, compared to Left ventricular ejection fraction (LVEF). LVEF is the most extensively used and investigated cardiac pumping function for many decades. However, recent reports have prompted that relationship between LVEF and mortality in heart failure patients with inappropriate or unsatisfactory results; where reduced GLS has been an extraordinary predicting measure to provide a good prognosis for many heart failure-related outcomes independent of LVEF.}, key = {pmid30581982}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Faisaluddin_2018c, title = {Novel imaging modalities to predict the development of atrial fibrillation post stroke}, author = {Mohammed Faisaluddin and Dhrubajyoti Bandyopadhyay and Adrija Hajra and Hassan Beydoun and Raktim K. Ghosh and Eyal Herzog}, url = {https://www.sciencedirect.com/science/article/pii/S2352906718301726?via%3Dihub}, doi = {10.1016/j.ijcha.2018.12.002}, issn = {2352-9067}, year = {2018}, date = {2018-12-13}, urldate = {2018-12-13}, journal = {IJC Heart &$mathsemicolon$ Vasculature}, volume = {22}, pages = {46-47}, publisher = {Elsevier BV}, key = {pmid30581981}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Kumari_2018, title = {Block vertebrae of 5th lumbar and 1st sacral vertebra}, author = {Vanacharala Anantha Kumari and Syeda Nasreen Fatima}, url = {https://www.ijmhr.org/IntJAnatRes/IJAR.2018.395}, doi = {10.16965/ijar.2018.395}, issn = {2321-4281}, year = {2018}, date = {2018-12-05}, journal = {International Journal of Anatomy and Research}, volume = {6}, number = {3}, issue = {4}, pages = {6009-6013}, publisher = {IMED Research Publications}, abstract = {Introduction: Vertebral column is centrally placed structure in the body providing stability, posture, motility and transmission of weight of the body. Disruption during development leads to congenital abnormalities. Fusion of Fifth lumbar vertebra with first sacral can be a congenital abnormality or acquired. Materials and Methodology: The present study was conducted on 100 dried adult human sacrum of both sexes obtained from Department of anatomy, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad in May-June 2018. Result: In the present study out of 100 sacra there were 24 fusion of last lumbar vertebra with sacrum. In all cases sacralisation was found to be complete and bilateral. The body, spines, transverse processes, laminae, pedicles and the articular processes were all fused. All the fused vertebrae observed belonged to males. Discussion: In the present study there is blocking of vertebrae in about 24% of cases. All the fused vertebrae belonged to males showing higher incidence of blocking of vertebrae in males. Magora and Schwartz in 1978 found sacralisation in 20.8% of cases. 1.7% to 14% of sacralisation was reported by Castellvi et al in 1983.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Ali_2018c, title = {Role of colour doppler in the evaluation of carotid artery disease in patients of stroke}, author = {Syed Althaf Ali and R. Prabhakar Rao}, url = {https://www.medpulse.in/Radio%20Diagnosis/Article/Volume8Issue3/Radiology_8_3_1.pdf}, doi = {10.26611/1013831}, issn = {2579-0927}, year = {2018}, date = {2018-12-04}, urldate = {2018-12-04}, journal = {MedPulse International Journal of Radiology}, volume = {8}, issue = {3}, pages = {44-51}, publisher = {Statperson Publishing Coporation}, abstract = {Objective: To study the role of carotid in role of carotid artery stenosis, evaluatrion of plaque and distribution of risk factors between Non-Lacunar and Lacunar subtypes, in patients with stroke. Design: A prospective cross sectional study by single operator using Doppler ultrasound for plaque characterization and to obtain flow velocity wave forms in Carotid vessels. Duration: September 2016 to November 2017. Setting: Department of Radio-diagnosis in association with Department of Medicine, Deccan College of Medical Sciences, Hyderabad. Participants: Seventy patients with positive CT findings of ischemic stroke admitted in DCMS. Methods: Pearson’s chi square-correlation estimation with Y ates correction, Odds ratio, unpaired ‘t’ test were used for the data tabulated from the flow velocity waveforms. Results: Non-Lacunar stroke patients were associated with male sex, smoking, alcohol, highe mean age, higher Carotid IMT(1.1mm), more echolucent plaques(76%) and Carotid artery stenosis(82.5%) compared to Lacunar stroke. In our study diabetes and hypertension did not show any significant difference in association between Lacunar and Non-Lacunar stroke. Conclusion: Presence with presence of risk factors for atherosclerosis, increased IMT and echolucent plaques on carotid Doppler study are at a higher risk for future stroke and must be followed up for progression of atherosclerosis.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Khaleel_2018, title = {Detection of extended spectrum beta lactamases in gram negative isolates causing urinary tract infection in tertiary care centre}, author = {Mohammed Khaleel and Rozina Arshi Khan and Syeda Daniya Samreen and Syeda Juvaria Arshi}, url = {https://www.ijmmtd.org/journal-article-file/7974}, doi = {10.18231/2581-4761.2018.0051}, issn = {2581-4753}, year = {2018}, date = {2018-12-01}, urldate = {2018-12-01}, journal = {International Journal of Medical Microbiology and Tropical Diseases}, volume = {4}, issue = {4}, pages = {234-239}, abstract = {Introduction: Urinary Tract infection (UTI’s) is the most commonly encountered infectious disease, affecting both the sexes in all age groups. This leads to consumption of large number of antibiotics and development of resistant strains leading to complications. Objective: The study was carried out to know the distribution pattern and to evaluate the sensitivity of ESBL producing urinary isolates from patients with UTI. Materials and Methods: A cross sectional study was conducted at Owaisi Hospital and Research Centre for 6months. A total of 392 samples were obtained from suspected UTI patients. Clean catch mid stream urine samples obtained were subjected to microscopy, culture and antibiotic sensitivity testing as per CLSI guidelines. Results: From the total of 392 samples, 200 samples i.e. 51% samples were culture positive. Among the culture positive cases, 69% were females, 35% were males. 38.8% of Esch.coli and 25% Klebsiella were predominant ESBL producers. Conclusion: This study revealed that majority of Gram negative urinary isolates are ESBL producers, and multidrug resistant. Thus strict policy with guidelines for antibiotic susceptibility testing and prescription should be followed to prevent further emergence of resistant strains and treatment failure. }, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018d, title = {Chronic tophaceous gout with unusual large and multiple tophi at various joints with acute cellulitis like presentation at great toe: case report}, author = {Mazharuddin Ali Khan and Syed Yaser Quadri and Wasif Ishaqui}, url = {https://www.ijsr.net/archive/v7i11/19101805.pdf}, issn = {2319-7064}, year = {2018}, date = {2018-11-30}, urldate = {2018-11-30}, journal = {International Journal of Science and Research}, volume = {7}, issue = {11}, pages = {945-950}, abstract = {Gout is a metabolic disease, which is characterized by acute or chronic arthritis, and deposition of monosodium urate crystals in joint, bones, soft tissues, and kidneys. But large tophi are unusual in chronic gout. We report the case of a 48-year-old resident of Kandukur region of Rangareddy district, Telangana, Hyderabad, presenting chronic tophaceous gout with unusual large tophi involving multiple joints: hands, feet, elbows, and knees and acute cellulitis/Abscess like presentation on left foot. Laboratory workup revealed normal serum uric acid (5.4 mg/dl,male it is 3.5–8.7 mg/dL and in case of female it is 2.5–6.9 mg/dL)1 with normal renal function test. In untreated patients, chronic tophaceous gout may develop, which is characterized by chronic destructive polyarticular involvement and tophi. The treatment consists to decrease serum uric acid level which eventually allows the regression of tophi.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Kahkashan_2018, title = {Variation in carotid-femoral pulse wave velocity, augmentation pressure and augmentation index during different phases of menstrual cycle}, author = {Nudrath Kahkashan and Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari and Safia Sultana and Farah Fatima and Syyeda Anees}, url = {https://amphysiol.com/index.php/amp/article/view/v2i3.10454}, doi = {10.23921/amp.2018v2i3.10454}, issn = {2456-8422}, year = {2018}, date = {2018-11-28}, urldate = {2018-11-28}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {3}, pages = {27-32}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, abstract = {Physiological variation of estrogen and progesterone during menstrual cycle is well known. They not only have an effect on blood pressure control, but also seem to have a role in regulating arterial compliance. This study was done to find out whether there are any changes in central arterial parameters during different phases of menstrual cycle. Thirty female subjects in the age group of 18-22 years with normal, regular menstrual cycles participated in this prospective observational study at our teaching hospital. Anthropometric parameters were recorded. Blood pressure in all 4 limbs was recorded using cardiovascular risk analyzer-Periscope™ on Day 3rd to 5th (follicular phase), Day 12th to 14th (ovulation phase), Day 22nd to 24th (luteal phase) of their menstrual cycle. We collected blood samples during these three phases for estimation of estradiol and progesterone by ELISA technique. Analysis of variance and correlation statistics were done using SPSS 17.0 statistical software. No significant statistical changes were observed in systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure, aortic systolic pressure, aortic diastolic pressure, aortic augmentation pressure, aortic index and pulse wave velocity during the three recorded phases of the menstrual cycle. There are many studies which correlate changes in peripheral artery blood pressure with different phases of menstrual cycle. But there is scarcity in data available which correlates central arterial pressures and arterial stiffness with natural hormonal variations in different phases of menstrual cycle. However, our results show that although there are subtle changes in blood pressure parameters along with estrogen and progesterone levels throughout the menstrual cycle, yet these were not statistically significant.}, keywords = {Biochemistry, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2018c, title = {Hemorheology: Capturing the fluid dynamics of blood}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v2i3.15965}, doi = {10.23921/amp.2018v2i3.15965}, issn = {2456-8422}, year = {2018}, date = {2018-11-28}, urldate = {2018-11-28}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {3}, pages = {25-26}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018b, title = {Bioengineered functional humanized livers: an emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases}, author = {Sandeep Kumar Vishwakarma and Chandrakala Lakkireddy and Avinash Bardia and Syed Ameer Basha Paspala and Chaturvedula Tripura and Md. Aejaz Habeeb and Aleem Ahmed Khan}, url = {https://f6publishing.blob.core.windows.net/fbbe1f7d-af5e-44ac-9cbd-ad7683f01680/WJH-10-822.pdf}, doi = {10.4254/wjh.v10.i11.822}, issn = {1948-5182}, year = {2018}, date = {2018-11-27}, urldate = {2018-11-27}, journal = {World Journal of Hepatology}, volume = {10}, issue = {11}, pages = {822-836}, publisher = {Baishideng Publishing Group Inc.}, abstract = {End stage liver diseases (ESLD) represent a major, neglected global public health crisis which requires an urgent action towards finding a proper cure. Orthotropic liver transplantation has been the only definitive treatment modality for ESLD. However, shortage of donor organs, timely unavailability, post-surgery related complications and financial burden on the patients limits the number of patients receiving the transplants. Since last two decades cell-based therapies have revolutionized the field of organ/tissue regeneration. However providing an alternative organ source to address the donor liver shortage still poses potential challenges. The developments made in this direction provide useful futuristic approaches, which could be translated into pre-clinical and clinical settings targeting appropriate applications in specific disease conditions. Earlier studies have demonstrated the applicability of this particular approach to generate functional organ in rodent system by connecting them with portal and hepatic circulatory networks. However, such strategy requires very high level of surgical expertise and also poses the technical and financial questions towards its future applicability. Hence, alternative sites for generating secondary organs are being tested in several types of disease conditions. Among different sites, omentum has been proved to be more appropriate site for implanting several kinds of functional tissue constructs without eliciting much immunological response. Hence, omentum may be considered as better site for transplanting humanized bioengineered ex vivo generated livers, thereby creating a secondary organ at intra-omental site. However, the expertise for generating such bioengineered organs are limited and only very few centres are involved for investigating the potential use of such implants in clinical practice due to gap between the clinical transplant surgeons and basic scientists working on the concept evolution. Herein we discuss the recent advances and challenges to create functional secondary organs through intra-omental transplantation of ex vivo generated bioengineered humanized livers and their further application in the management of ESLD as a supportive bridge for organ transplantation.}, key = {pmid30533183}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{DeSouza_2018, title = {Study to describe association between depression and alcohol dependence in teaching hospital, Telangana}, author = {Rene De Souza and Syed Mateen}, url = {https://rfppl.co.in/subscription/upload_pdf/Rene%20De%20Souza_7973.pdf}, doi = {10.21088/jpn.2277.9035.7318.2}, issn = {2277-9035}, year = {2018}, date = {2018-11-22}, urldate = {2018-11-22}, journal = {Journal of Psychiatric Nursing}, volume = {7}, issue = {3}, pages = {79-84}, abstract = {Introduction: Alcohol dependence and depression coexist with each other. Now a day’s people use alcohol as a source to relieve their depression. But alcohol dependence increases the harmful effects on the body, also resulting in suicidal tendencies. Aim of the Study: To study the association between depression and alcohol dependence. Materials and Methods: Adescriptive study was done in the department of Psychiatry at Kamineni Institute of Medical Sciences, L.B. Nagar, Telangana for duration of one year from May 2017 to June 2018. A total of 120 cases who had history of alcohol intake associated with alcoholic dependence and depression were included in the study. SADQ and HAM-D were used to assess severity of alcohol dependence and depression. Results: In the present study, majority of the patients were in the age group of 41-50 years (62.5%). 41.6% (50/120 ) started intake of alcohol at the age of 21-30 years.In the present study there was a male predominance, about 91.6% and females about only 8.3 %. Majority of the patients consumed > 60 gm/24hr of alcohol, i.e., 83.3%(100/120). 33.3% (40/120) were married, while 25% (30/120) were unmarried and 25% were divorced and 16.6% (20/120) were committed but not married. Depression was seen in all 120 cases. Conclusion: The prevalence of depression among alcohol-dependent persons is high. There is recovery from depression after alcohol detoxification and rehabilitation, and majority of the cases do not necessarily require treatment for the depression. In addition persons that are depressed have a significantly higher craving for alcohol after detoxification and rehabilitation. It is important to screen for depression and evaluate to determine the treatment needs during detoxification and rehabilitation.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018e, title = {A rare presentation of a multi-septate extra-articular ganglion cyst around the knee joint}, author = {Mazharuddin Ali Khan and Syed Yaser Quadri and Shaik Vazeer Uddin}, url = {https://www.journalijar.com/uploads/848_IJAR-25431.pdf}, doi = {10.21474/IJAR01/8072 }, issn = {2320-5407}, year = {2018}, date = {2018-11-01}, urldate = {2018-11-01}, journal = {International Journal of Advanced Research}, volume = {6}, issue = {11}, pages = {866-871}, abstract = {A Multi-septate Extra-Articular Ganglion Cyst At Anterioinferio medial region of Knee joint Is Abstracted and management with surgically excision . Ganglion cysts are benign soft tissue swellings commonly found in the wrist. The etiology of ganglion cysts is unknown or traumatic. Ganglion cysts can occur at any joint or tendon sheath, but they most often present in the dorsum of the wrist at the scapholunate joint, 75% connect with the dorsal scapholunateinterosseous ligament, other sites of ganglion are dorsal carpal ganglion ,second and third CMC joint,DIP (mucous cyst),flexor sheath,guyon`s canal ,ulnar carpus, volar carpal ganglion ,volar retinacular ganglion but rarely to originate in the knee joint . Ganglion cysts are filled with gelatinous and viscous fluid .Many patients will be asymptomatic cysts for months or even years . In general, ganglion cysts around the knee joint are classified into intra-articular, extra-articular soft tissue, periosteal, and intra-osseous ganglion cysts. Extra-articular ganglion cysts usually appear as uni- or multi-septate cysts on magnetic resonance imaging (MRI). }, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018c, title = {Bioengineering human neurological constructs using decellularized meningeal scaffolds for application in spinal cord injury}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Chandrakala Lakkireddy and Syed Ameer Basha Paspala and Aleem Ahmed Khan}, url = {https://www.frontiersin.org/articles/10.3389/fbioe.2018.00150/full}, doi = {10.3389/fbioe.2018.00150}, issn = {2296-4185}, year = {2018}, date = {2018-11-01}, urldate = {2018-11-01}, journal = {Frontiers in Bioengineering and Biotechnology}, volume = {6}, publisher = {Frontiers Media SA}, abstract = {Spinal cord injury (SCI) is one of the most devastating conditions echoes with inflammation, enhanced fibrosis and larger axonal gaps due to destruction of neurological cells which has caused continuous increasing mortality rate of SCI patients due to absence of suitable treatment modalities. The restoration of structural and functional aspect of damaged neurological tissues at the lesion site in spinal cord has been challenging. Recent developments have showed tremendous potential of neural stem cell-based strategies to form a neuronal relay circuit across the injury gap which facilitates some levels of improvement in SCI condition. However, to provide better therapeutic responses, critical mass of grafted cells must survive for long-term and differentiate into neuronal cells with well-developed axonal networks. Hence, development of tissue specific biological neuronal constructs is highly desirable to provide mechanical and biological support for long-term survival and function of neurological cells within natural biological niche. In this study, we report development of a tissue specific neuronal constructs by culturing human neural precursor cells on decellularized meningeal scaffolds to provide suitable biological neuronal construct which can be used to support mechanical, structural and functional aspect of damaged spinal cord tissues. This particular tissue specific biological construct is immunologically tolerable and provides precisely orchestral three-dimensional platform to choreograph the long-distance axonal guidance and more organized neuronal cell growth. It passes sufficient mechanical and biological properties enriched with several crucial neurotrophins required for long-term survival and function of neurological cells which is required to form proper axonal bridge to regenerate the damaged axonal connectomes at lesion-site in SCI.}, key = {pmid30443545}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018, title = {Molecular dynamics of pancreatic transcription factors in bioengineered humanized insulin producing neoorgan}, author = {Sandeep Kumar Vishwakarma and Chandrakala Lakkireddy and Avinash Bardia and Nagarapu Raju and Syed Ameer Basha Paspala and Md. Aejaz Habeeb and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0378111918307753?via%3Dihub}, doi = {10.1016/j.gene.2018.07.006}, issn = {0378-1119}, year = {2018}, date = {2018-10-30}, urldate = {2018-10-30}, journal = {Gene}, volume = {675}, pages = {165-175}, publisher = {Elsevier BV}, abstract = {Background: The present study has been aimed to identify molecular dynamics of pancreatic transcription factors (pTFs) during events of directed trans-differentiation of human hepatic progenitor cells (hHPCs) into insulin producing cells (InPCs) within bioengineered humanized neoorgan. The study demonstrates applicability of acellularized whole splenic scaffold (ASOS) to generate insulin producing humanized transplantable neoorgan through activation of pancreatic transcription factors. Methods: An efficient acellularization process was developed for xenogeneic rat spleen using change in different gradients of reagents perfusion through splenic artery for varying time points. The acellularized xenogeneic spleen scaffold was characterized thoroughly for preservation of extra-cellular matrix and retention of organ specific vasculature and mechanical properties. Further scaffolds were sterilized and repopulated with hHPCs which were triggered using a stage wise induction with growth factors and hyperglycemic challenge for trans-differentiation into InPCs. Dynamics of pTFs alone or simultaneously during induction process was identified using gene expression analysis and immunological staining. Results: The cells within the engineered neoorgan respond to growth factors and extrinsic hyperglycemic challenge and generate large number of InPCs under controlled dynamic regulation of pTFs. Highly controlled regulation of pTFs generates higher percentage of Nkx-6.1+/C-peptide+ cells within the engineered splenic scaffolds. Generation of high percentage of insulin and C-peptide positive cells in three-dimensional organ architecture responded better to hyperglycemic stimuli and produced higher quantity of insulin than 2D-culture system. Conclusion: The present study provides a novel platform for designing effective regenerative strategies using whole organ scaffolds to control hyperglycemia under tight regulation of pTFs using humanized neoorgan system.}, key = {pmid30180963}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Supriya_2018, title = {Abnormal uterine bleeding: role of sonography and histopathology in endometrial study with emphasis on the organic causes}, author = {M. Supriya and Atiya Begum}, url = {https://www.ijpo.co.in/journal-article-file/6428}, doi = {10.18231/2394-6792.2018.0048}, issn = {2394-6784}, year = {2018}, date = {2018-10-16}, urldate = {2018-10-16}, journal = {Indian Journal of Pathology and Oncology}, volume = {5}, issue = {2}, pages = {262-268}, abstract = {Introduction: Abnormal uterine bleeding (AUB) is the most common complaint in women of all age groups. The causes for abnormal bleeding needs to be evaluated before subjecting the patient to complicated surgical procedures. Transvaginal sonography is a simple outpatient procedure to identify suitable candidates for endometrial biopsy which provides an accurate diagnosis. Aims and Objectives: 1. To emphasize on the correlation of sonology and histopathological findings and to provide the cause of pathology for Abnormal Uterine Bleeding (AUB) in majority of cases. 2. To study the clinical data of the patients presenting with AUB and its histopathological spectrum. Materials and Methods: This was a prospective study conducted in the department of Pathology over a period of one year from January 2016 to December 2016. Endometrial biopsies of patients of all age groups presenting with a chief complaint of Abnormal uterine bleeding and abnormal USG findings were included in the study while inadequate biopsies and patients with genital infections, pregnancy–complications were excluded. The biopsies were processed as per the standard protocol. Histopathological examination was done and the diagnosis was given. Results were statistically analyzed. Results: A total of 87 cases were analyzed based on age, clinical presentation, parity, correlation of sonography- histopathological findings was done and the results were found to have statistically significant p values. Conclusion: A combination of sonography with histopathology provides an accurate diagnosis for AUB in most of the cases, specifically those with organic pathology. }, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Tirunagari_2018, title = { Koch’s with Kikuchi together in a young male}, author = {L. N. Swamy Tirunagari and Ashfaq Hasan}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120309/pdf/LI-35-443.pdf}, doi = {10.4103/lungindia.lungindia_422_17}, issn = {0970-2113}, year = {2018}, date = {2018-10-01}, urldate = {2018-10-01}, journal = {Lung India}, volume = {35}, issue = {5}, pages = {443-444}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018b, title = {Clinical examination for complex fistula in ano: relevance in present times-a clinical study}, author = {Bushra Khan and Nikhilesh Vedire and Ismail Khan and Akshan Ugale and Ganji Ravi and Mohammed Abdul Hadi}, url = {https://www.apjhs.com/index.php/apjhs/article/view/271/231}, doi = {10.21276/apjhs.2018.5.3.9}, issn = {2349-0659}, year = {2018}, date = {2018-09-30}, urldate = {2018-09-30}, journal = {Asian Pacific Journal of Health Sciences}, volume = {5}, issue = {3}, pages = {67-76}, abstract = {Background: Fistula in Ano has been known as a chronic painful disease since centuries past with no proven well defined course of management even till the present times. This has given rise to various forms of treatment ranging from seton to flaps. Materials and Methods: Total 83 adult patients with age ranging from 16 to 70 years were studied over a span of 8 years starting from Jan‟10 to Dec‟17. Clinical findings were compared with MR Imaging and correlated with Intraoperative Methylene blue injection. The findings were tabulated and compared regarding effectiveness of each method in determining the exact anatomy of the fistula and statistical significance was determined by Chi square test. Results: Our studies showed that the chances of detecting the internal opening by clinical examination is significantly better than MRI, however neither clinical examination nor MRI is a full proof mechanism for detecting the type of fistula. Conclusion: Even though Imaging is better at detecting the fistula anatomy there is still a role for a proper clinical examination in outpatient department. Clinical Examination compares favorably with MR Imaging in detecting Internal Opening of a Fistula. Even in complicated Fistulas, a proper clinical examination is better than Imaging in detection of anatomy of a fistula, even though there is no statistically significant difference between the two methods.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Naz_2018, title = {Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients}, author = {Saima Naz and Rafiq Ahmad Khan and Jeevan Giddaluru and Srikanth Battu and Sandeep Kumar Vishwakarma and Mabu Subahan and Vishnupriya Satti and Nooruddin Khan and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0008874918302600?via%3Dihub}, doi = {10.1016/j.cellimm.2018.09.003}, issn = {0008-8749}, year = {2018}, date = {2018-09-21}, urldate = {2018-12-01}, journal = {Cellular Immunology}, volume = {334}, pages = {42-48}, publisher = {Elsevier BV}, abstract = {Ulcerative colitis (UC) is a persistent inflammatory illness, which is clinically categorised as Inflammatory bowel disease (IBD), affecting millions of people worldwide. The precise cause behind the pathology of the disease remains unknown. However, the involvement of multiple factors including genetic predisposition, immunological deregulations, microbiota imbalance, and environmental triggers has been suggested. Amongst all these factors, the over-active immunological response reported in UC patients seems to be a promising target for therapy. Moreover, identification of gene signatures associated with disease onset and progression would help in better understanding of the molecular mechanisms involved in the disease pathogenesis. Here, we have conducted meta-analysis of gene expression profiles of UC patient microarray datasets accessible in public databases and further validated the in-silico findings in UC patients’ blood samples. Our study reveals that UC pathogenesis perturbs expression of several inflammatory genes. In addition, we report a novel gene signature comprising of TIA1 (T cell restricted intracellular antigen) and TIAR (TIA1 related protein; also known as TIAL1), which were found to be significantly downregulated in UC patients. TIA1 and TIAR are RNA-binding proteins (RBPs), which function as a translational represser by binding to ARE sequences in the 3′ UTR of mRNAs encoding inflammatory mediators including cytokines. Our findings demonstrate that deletion of TIAR using gene specific siRNAs in-vitro results in enhanced production of inflammatory cytokine IL-1β. In conclusion, the findings of this study reveal that down regulation of TIA1/TIAR genes could be responsible for UC associated inflammation. This study highlights the usefulness of the meta-analysis approach in the identification of unique gene signatures that might deliver mechanistic insights into UC pathogenesis and possibly assist in discovery of prognostic markers and therapeutic interventions.}, key = {pmid30327138}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Naveed_2018, title = {N-acetylcysteine in a treatment of COPD}, author = {M. Aleemuddin Naveed and Raheem Fatima and Mohammed Mohsin and Ashfaq Hasan}, url = {https://www.ijirm.org/journal-article-file/7457}, doi = {10.18231/2581-4222.2018.0035}, issn = {2581-4214}, year = {2018}, date = {2018-09-01}, urldate = {2018-09-01}, journal = {IP Indian Journal of Immunology and Respiratory Medicine}, volume = {3}, issue = {3}, pages = {137-146}, abstract = {Introduction: In COPD excess expectoration secondary to tracheobronchial secretions contributes to symptoms, airflow obstruction and is diagnostic criterion. It also causes increased mortality, risk of hospitalizations and accelerated decline in FEV1. N-acetylcysteine (NAC) helps in liquefying mucus and DNA (via disruption of disulfide bonds) and has antioxidant effects. Aims: Evaluate add-on effect of NAC on clinical-physiological parameters in COPD patients treated according to GOLD guidelines. Material and Methods: Single labeled, randomized, parallel group prospective Observational study. In 120 stable COPD patients Modified medical research council (MMRC) dyspnoea score, COPD Assessment test (CAT score), number of exacerbations and hospitalizations in the last year were recorded and were randomized into 2 groups of 60 each. Group A received NAC 600mg twice daily along with standard treatment. Group B received standard treatment only. Mean and Standard Deviation was compared between groups using unpaired t-test. After 1 year, changes in above parameters were reassessed. Statistical Analysis: Unpaired t-test and chi square test were used. Statistical significance was set at <0.05 level. Results: MMRC score reduced from 3.37 study group) to 2.91, difference being -0.46, and in control from 3.37 to 1.18, difference of -0.22 and p value of p<.05. CAT score reduced more in test group (-4.4) than control group (-3.1), p=.02. Out of 40 exacerbations, 14 (35%) occurred in test and 26 (65%) in control group, reduction of 30% and p=0.01. Out of 28 hospitalizations 10 (36%) test group 18 (64%) control group. i.e. a reduction of 28% and p=0.06. Conclusions: Use of N-Acetyl Cysteine, 600mg twice daily along with standard treatment can bring clinically significant change in CAT Score and frequency of exacerbations but not in MMRC score and hospitalizations. }, keywords = {Pharmacology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Naeem_2017b, title = {Influence of glycemic control on platelet count in type II diabetics in absence of vascular complications}, author = {Kazi Husna Abdul Naeem and Mohammed Abdul Hannan Hazari and Farisa Khatoon and Farah Bahmed and Fariha Mohammedi }, url = {https://www.medpulse.in/Physiology/Article/Volume5Issue2/Physiology_5_2_4.pdf}, doi = {10.26611/103524}, issn = {2550-7613}, year = {2018}, date = {2018-08-23}, urldate = {2018-08-23}, journal = {MedPulse International Journal of Physiology}, volume = {5}, issue = {2}, pages = {22-24}, abstract = {Background: Diabetes mellitus (DM) has attained a state of a global emergency with increasing prevalence worldwide. Altered thrombocyte morphology, count and function have been reported with diabetics. The present study aimed at determining the variation in platelet count with degree of glycaemic control in Type 2 diabetes patients. Methods: A total of 200 subjects were enrolled in the study of which 100 had HbA1c < 6.5 and 100 had HbA1c > 6.5. Sample for glucose estimation and platelet indices were collected and estimation were carried out by the auto-analyzer. The statistical evaluation was done using SPSS version 22. Student t- test was used for comparison between two variables namely HbA1c and platelet count. Results: Mean Platelet count was found to be significantly higher in patients with type -2 diabetes mellitus with HbA1C > 6.5 in comparison to patients having HbA1c < 6.5.(p < 0.01) Conclusion: This study revealed a higher mean platelet count for diabetics with poor glycaemic control than for diabetics with good glycaemic control. However, platelet counts in both groups were within the normal reference range for healthy individuals. Platelet count with other platelet indices like Mean Platelet Volume and Platelet Distribution Width are simple, effective and cheap tests that may be used to predict vascular complications in type 2 DM.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uz_Zaman_2018, title = {Insertion element mediated mgrB disruption and presence of ISKpn28 in colistin-resistant klebsiella pneumoniae isolates from Saudi Arabia}, author = {Taher Uz Zaman and Maha Albladi and Mohammed Ismail Siddique and Sameera M. Al Johani and Hanan H. Balkhy}, url = {https://www.dovepress.com/getfile.php?fileID=43697}, doi = {10.2147/idr.s161146}, issn = {1178-6973}, year = {2018}, date = {2018-08-15}, urldate = {2018-08-15}, journal = {Infection and Drug Resistance}, volume = {11}, pages = {1183-1187}, publisher = {Informa UK Limited}, abstract = {Background: In Klebsiella pneumoniae, mgrB and components of pmrHFIJKLM operon play a major role in colistin resistance. Methods: We analyzed 23 nonduplicating colistin-resistant K. pneumoniae isolates, collected during the years 2011–2015, for the possible mechanism underlying their nonsusceptibility to colistin. Isolates were tested for their minimum inhibitory concentrations and antibiotic resistance determinants and genotyped by multilocus sequence typing (MLST). The MLST genes, antibiotic-resistant genes, and the genes of two component system (TCS), including mgrB, PhoQ/PhoP, pmrA/B, and CrrAB, were investigated by PCR amplification and Sanger sequencing. Results: All isolates were distributed in eight sequence types (STs) and showed mutations either in mgrB or PhoP genes. ISKpn14 was found in 10, ISKpn28 in four, and IS903 in three isolates. One isolate showed deletion of a single nucleotide in mgrB open reading frame causing premature stop codon. L26Q substitution in PhoP was found in five isolates. Conclusion: The mutations in mgrB were mostly mediated by insertion elements (IS). ISKpn14 is the major IS while ISKpn28 is reported for the first time in mediating mgrB disruption. IS903, an IS5 family member, involved in mgrB disruption in three ST-152 NDM-1-positive isolates, was previously responsible for omp-36 disruption in our carbapenem-resistant K. pneumoniae and appears to contribute to transform the isolates into a pan-drug ones. Also, the abundance of insertion sites in mgrB indicates the plasticity of this gene. In our isolates, IS-mediated colistin resistance appears to be a later phenomenon than mutation in PhoP gene.}, key = {pmid30147346}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Ali_2018, title = {Prevalence of cuff hypertension among overweight and obese subjects}, author = {Syed Imran Ali and Farisa Khatoon and Mohammed Abdul Hannan Hazari and Nazia Uzma and Fariha Mohammedi}, url = {https://njppp.com/?mno=292752}, doi = {10.5455/njppp.2018.8.0308806032018}, issn = {2231-3206}, year = {2018}, date = {2018-07-31}, urldate = {2018-07-31}, journal = {National Journal of Physiology, Pharmacy and Pharmacology}, volume = {8}, issue = {7}, pages = {1018-1021}, publisher = {ScopeMed}, abstract = {Background: Obesity is a lifestyle affliction, it is a side effect of poor habit and it can be reversed. Obesity is defined either by increased waist circumference, waist-hip ratio, and/or body mass index. Overestimation of blood pressure (BP) using an inappropriately small cuff is well documented. Using a BP cuff small for midarm circumference (AC) in obese patient's results in higher BP readings. Therefore, it was felt that there is a requirement to study the effect of different cuff sizes for different arm circumferences in obese individuals. The purpose of this study is to determine if cuff hypertension (HTN) is present in obese subjects. Aims and Objective: To determine the presence of cuff HTN in obese subjects. Materials and Methods: A total of 200 obese and 200 non-obese subjects between 20 and 50 years of age reporting to OHRC were included in the study. Systolic and diastolic BP were measured using a mercury sphygmomanometer with two cuff sizes, i.e., standard cuff 12 cm width (for MAC <32 cm) and large cuff 15 cm width (for MAC >32 cm). Results: A total of 56 subjects were diagnosed as systolic HTN with standard cuff, i.e., 28% but with large cuff, it was only 24 subjects, i.e., 12% only, a difference of 16% between the prevalence of systolic HTN. Diastolic HTN diagnosed with standard cuff was 20% compared to large cuff 7.5%, a difference of 12.5%. The above differences are demonstrating 'cuff HTN' in the obese subjects. Conclusion: In this study of 200 obese and 200 non-obese subjects, it was found that 'cuff HTN' is present in obese subjects.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Naaz_2018, title = {Role of ultrasonography in diagnosis of neck mass}, author = {Farah Naaz and Urooj Ahmed Choudhary and Hamid Abdul Qaiyum}, url = {https://www.ejmanager.com/mnstemps/154/154-1519710525.pdf?t=1693212094}, doi = {10.5455/jmas.292149}, issn = {2231-1696}, year = {2018}, date = {2018-07-31}, urldate = {2018-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {8}, issue = {2}, pages = {66-72}, abstract = {A cross section study on diagnostic role of ultrasonography (USG) in neck swellings was done in the department of Otorhinolaryngology of this institution. The study of ultrasonographic features of various neck swellings was done in fifty patients. The mean age of subjects was 33.04 years with a range from 1 year to 79 years and the maximum number of cases were in the age group of 31-39 years. Male and female incidence was 24% and 76% respectively. Out of 50 patients who underwent USG examination 76% had thyroid swelling. Various ultrasonographic features like echogenicity, echotextures were noted. 68% of patients had mass with solid consistency on USG while 32% had cystic nature. 72% of patients were recorded with hypoechogenic echotexture on USG. Benign nature of swelling was diagnosed on 78% of patients. 12% of neck swelling patients had features predictive of malignancy on USG. Clinical diagnosis and USG diagnosis was correlated and found to have a diagnostic accuracy of 86%. Thyroid swellings (38)100% the diagnostic value of USG was 86% for benign lesions and 14% in malignant lesions. Fine needle aspiration cytology (FNAC) showed 76% benign lesions and 24% malignant thyroid swellings. Patients presenting with a neck mass whether benign or malignant need a methodical approach for an accurate diagnosis and appropriate treatment. USG helps in differentiating the true nature of swelling whether as solid or cystic. In the present study USG of thyroid clearly provides conformity on benign pathology and prediction regarding malignant nature. USG provides information regarding benign or malignant nature of lymph nodes. From the present study it can be concluded that for proper diagnosis of thyroid lesion, FNAC is the main diagnostic modality along with ultrasonography.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Sarah_2018, title = {Prevalence of anxiety and depression among medical students of Deccan Medical College, Hyderabad}, author = {Sayeedunnisa Sarah and Sultan Rizwan Ahmad and A. Chandrasekhar}, url = {http://journal.njrcmindia.com/index.php/njrcm/issue/view/7/5}, doi = {10.26727/NJRCM.2018.7.3.229-232}, issn = {2277-1522}, year = {2018}, date = {2018-07-31}, urldate = {2018-07-31}, journal = {National Journal of Research in Community Medicine}, volume = {7}, issue = {3}, pages = {229-232}, abstract = {Background:Different Studies on depression in medical students have shown high prevalence of 20-30%. Anxiety especially in new medical students and during examination periods is another common mental health problem that needs attention, as very few Medical students seek medical/psychiatric help for these problems Objectives:To assess the prevalence of Depression Anxiety and Stress in Medical students. To assess the patterns of Depression, Anxiety and Stress in relation to the severity and distribution amongMedical students.Methodology:A cross-sectional study was conducted in the month of November 2017 in Deccan College of Medical Sciences, Hyderabad. Approval was obtained from Institutional ethical committee. A total of 275 Final MBBS [part-I (175) and Part-II (100)] students were selected for the study. Written informed consent was taken from study populationthat is the whole batch. Those students who were absent on the day of data collection and those who did not give consent to participate in study were excluded from the study. Incomplete responses where students have not attempted at least one options of the questioner were also excluded. Depression, Anxiety and Stress Scale -21 Items (DASS-21) was used for data collection. DASS-21 is a set of three self-report scales designed to measure the emotional states of depression, anxiety and stress.Results:A total of 275 Students were included in the study of which 175 were studying in Final year part-I and 100 in Final year Part-II,65% were female and 35% were male students. Average age of the student was 20.3 years. We found that prevalence of depression among medical students were 28.72%. Among them 2.18 % had severe depression and 1% extremely severe depression.Conclusion:Around one third of the Medical students reported features of Depression and more than half reported features of Anxiety. Early recognition of vulnerable students like Failures, students with Language problems and learning difficulties, students from low socio-economic strata and their effective counseling at early stages by teachers will go long way in making of confident doctors and confident and proficient medical fraternity. Setting up students counseling centers at medical colleges where students can approach to discuss their difficulties, regular orientation and motivational programmers, change in approach of teaching from inimically authoritative to more benevolent and empathetic are other approaches that need serious considerations. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2018, title = {Down‘s syndrome‑ an independent risk factor of outcomes in isolated congenital duodenal atresia}, author = {G. Raghavendra Prasad and C. V. S. Lakshmi}, url = {https://www.jneonatalsurg.com/ojs/index.php/jns/article/view/440/pdf}, doi = {10.21699/jns.v7i3.787}, issn = {2226-0439}, year = {2018}, date = {2018-07-24}, urldate = {2018-07-24}, journal = {Journal of Neonatal Surgery }, volume = {7}, issue = {3}, pages = {32-35}, abstract = {Introduction: There is no consensus in the available literature whether the coexistence of Down’s syndrome has adverse effect on the outcomes of neonates born with congenital duodenal atresia. Materials and Methods: A total of 29 neonates with congenital duodenal atresia were retrospectively studied for demographic details, sepsis parameters at admission, management, morbidity, and mortality. The neonates who were premature. Results: The sepsis parameters such as total leukocyte counts, erythrocyte sedimentation rate, serum procalcitonin levels, and serum C‑reactive protein levels were significantly increased, and the platelets were significantly decreased at admission in Group B subjects, as compared to Group A subjects. There were no complications noted in Group A, while Group B had significant morbidity. The neonates with congenital duodenal atresia with Down’s syndrome had 3.27 times more relative risk of mortality than those without Down’s syndrome. Down’s syndrome appears to be an independent risk factor for mortality in isolated congenital duodenal atresia with attributable risk of 37.8%. Conclusion: The presence of Down’s syndrome is a significant independent adverse risk factor of outcomes in isolated congenital duodenal atresia.}, keywords = {Pediatric Surgery, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ashish_2018, title = {Therapeutic role of monoclonal antibodies in migraine: a new paradigm}, author = {Kumar Ashish and Mohammed Faisaluddin and Dhrubajyoti Bandyopadhyay and Kartik Dhaduk and Anupam Baral}, url = {https://www.ejinme.com/article/S0953-6205(18)30287-5/fulltext}, doi = {10.1016/j.ejim.2018.07.015}, issn = {1879-0828}, year = {2018}, date = {2018-07-19}, urldate = {2018-11-01}, journal = {European Journal of Internal Medicine}, volume = {57}, pages = {e9-e10}, publisher = {Elsevier BV}, abstract = {Migraine continues to be the 6th most disabling illness with extremely incapacitating neurological symptoms affecting approximately 39 millions of US population. Besides its chronic illness, migraine impacts a significant economic burden with billions spent each year on medical services. American employers lose more than $13 billion each year as a result of 113 million lost work days due to a migraine. Apart from its burden of a migraine attack itself, migraine increases the risk for other physical and psychiatric conditions.}, key = {pmid30031595}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2018b, title = {Nanophysiology: Real-time phenomenal perspective in biology}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v2i2.302175}, doi = {10.23921/amp.2018v2i2.302175}, issn = {2456-8422}, year = {2018}, date = {2018-06-30}, urldate = {2018-06-30}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {2}, pages = {17-18}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2018, title = {Comparative study of two cross-sectional modalities, ultrasonography (usg) and computed tomography (CT) scan regarding the assessment of acute pancreatitis}, author = {R. Prabhakar Rao and Syed Althaf Ali}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=June_2018_1527934776__144.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2018}, date = {2018-06-30}, urldate = {2018-06-30}, journal = {International Journal of Scientific Research}, volume = {7}, issue = {6}, pages = {5-7}, abstract = {The objective of this study was to compare the two cross sectional modalities, USG and CT regarding the assessment of acute pancreatitis. All patients were first screened with USG and then underwent contrast-enhanced CT for the confirmation of diagnosis. Both USG and CT assessment was compared using several parameters including pancreatic enlargement, peripancreatic collection, pancreatic necrosis, ascites, pleural effusion and thickened retroperitoneal fascial planes. Chi square test was used to study the association between the comparable variables. P value and Odds ratio was calculated to study the level of significance and degree of correlation. This study emphasizes on the high value of USG as an initial tool in the screening and diagnosis of acute pancreatitis, however the severe forms of pancreatitis with pancreatic necrosis and thickened retroperitoneal fascial planes are better detected on CT.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Neeluri_2018, title = {A study on victims of road traffic accidents attending casualty in a tertiary care hospital, Khammam}, author = {Rajesh Neeluri and Venkata Suresh Anga}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/3064/2209}, doi = {10.18203/2394-6040.ijcmph20182644}, issn = {2394-6032}, year = {2018}, date = {2018-06-22}, urldate = {2018-06-22}, journal = {International Journal Of Community Medicine And Public Health}, volume = {5}, issue = {7}, pages = {3034-3038}, abstract = {Background: As per global status report on road safety 2015, 1.25 million road traffic deaths occurred every year. Most common cause of death among those aged 15-29 years was road traffic accidents. The objectives of the study were to study the socio-demographic profile of the victims of road traffic accidents, to identify the risk factors responsible for road traffic accidents and to identify the various presenting injuries of road traffic accident victims. Methods: It was a Hospital based cross sectional study. Victims of road traffic accidents attending casualty during July 2011 – June 2012 were studied. A pretested semi structured questionnaire was administered. A total of 280 road traffic accident victims were interviewed during the study period. Data was entered in Microsoft excel sheet and analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results were expressed as proportions for different study variables. Results: Out of the 280 victims, majority 206 (73.57%) of study participants were males. The highest numbers of victims (34.20%) were between 21-30 years of age group. 40.71% were using two wheelers. Most of the accidents took place in the evening (6 pm to 12 am) i.e. 39.10%. Most common site of presenting injury was lower limb (40.71%). In this study 22.5% were under influence of alcohol while driving. Conclusions: Road traffic accidents were more in young age groups and in males. Road safety education should be promoted.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018d, title = {Association of CD14 and macrophage migration inhibitory factor gene polymorphisms with inflammatory microRNAs expression levels in ankylosing spondylitis and polyarthralgia}, author = {Sandeep Kumar Vishwakarma and Chandrakala Lakki Reddy and G. Sravani and B. V. S. Sastry and N. Raju and S. I. Ahmed and Aleem Ahmed Khan and Nooruddin Owaisi and Akash Jaiswal and Mazharuddin Ali Khan}, url = {https://onlinelibrary.wiley.com/doi/10.1111/iji.12366}, doi = {10.1111/iji.12366}, issn = {1744-3121}, year = {2018}, date = {2018-06-04}, urldate = {2018-06-01}, journal = {International Journal of Immunogenetics}, volume = {45}, issue = {4}, pages = {190-200}, publisher = {Wiley}, abstract = {This study aimed to investigate the genetic basis of ankylosing spondylitis (AS) and polyarthralgia (PA) conditions among Indian subjects through genotyping two immune regulatory genes CD14 (−159C>T) and MIF (−173G>C) and find their association with the expression levels of three circulating inflammatory miRNAs. This investigation may provide early genetic cause of these two forms of arthritis and more optimal biological targets to predict early therapeutic outcomes. A total of 140 patients (AS: 70 and PA: 70) and 156 controls were recruited from Indian population. CD14 and MIF genotyping was performed using ARMS–PCR. Expression level of three inflammatory miRNAs (miRNA-146a, miRNA-155 and miRNA-181) was quantified using RT–qPCR. C/T genotype of CD14 gene was found to cause 2.06-fold risk of developing AS (CI 1.06–5.98}, key = {pmid29863307}, keywords = {Central Research Laboratory, Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Syeda_2018, title = {Experimental evaluation of anti inflammatory activity of punica granatum peel extract in albino rats}, author = {Shakira Fathima Syeda and Sam Pavan Kumar G. and Pushpalatha C. and Mohammed Mohsin}, url = {https://caims.in/assets/journal/2018/CAIMS_Journal_Jan_-_Jun_2018___05.pdf}, issn = {2278-5310 }, year = {2018}, date = {2018-06-01}, urldate = {2018-06-01}, journal = {Journal of Chalmeda Anand Rao Institute of Medical Sciences}, volume = {15}, issue = {1}, pages = {117-122}, abstract = {Aim: The aim of present study is to evaluate Anti-inflammatory activity of Punica granatum. L peel extract in albino rats. Materials and Methods: Albino rats of either sex weighing between 150 grams to 200 grams were divided into five groups of six animals (30) i.e control(C), standard (S), Test-1 (T1), Test-2(T2) & Test-3 (T3). Different groups of rats had received dose calculated according to body weight. C group had received 5ml/kg of 2% gum Acacia suspension orally. Diclofenac suspension in 2% gum Acacia was given to the standard (S) group in the dose of 5mg/kilogram body weight, orally. T1 group had received 100mg/kg, T2 group had received 200mg/kg & T3 group had received 400mg/kg body weight, orally. After half an hour of drug administration, sub-plantar injection of Carrageenin was administered by a tuberculin syringe into the right hind paw of all rats. Right hind paw was marked by a marker pen, at the level of lateral malleolous and the paw was dipped into the mercury of the plethysmograph and paw volume was measured by mercury displacement method immediately, and after 1 hour, 2 hour, 3 hours of the sub-plantar injection of carrageenin. The difference of paw volume recorded at the beginning of the experiment and at the end of 1 hour, 2hour & 3 hour of carrageenin administration. Percentage inhibition of inflammation was calculated by formula % inhibition = Vc-Vt/Vc X 100. Result : Result will be recorded and results will be analyzed by appropriate statistical methods. Conclusion: The present study revealed that Punica granatum L peel extract show anti- inflammatory activity in albino wistar rats. }, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Jawaid_2018, title = {Rapid identification of M. tuberculosis complex and non tuberculosis mycobacterium in extra-pulmonary tuberculosis using MGIT 320 liquid culture system and MPT64 antigen test}, author = {Mahwish Jawaid and Qursheed Sultana and Ajaz Hussain and Mohammed Khaleel and Maimoona Mustafa}, url = {https://www.ijcmas.com/7-5-2018/Mahwish%20Jawaid,%20et%20al.pdf}, doi = {10.20546/ijcmas.2018.705.239}, issn = {2319-7692}, year = {2018}, date = {2018-05-10}, urldate = {2018-05-10}, journal = {International Journal of Current Microbiology and Applied Sciences}, volume = {7}, issue = {5}, pages = {2036-2044}, abstract = {Tuberculosis is a major cause of morbidity and mortality worldwide. Mycobacterium tuberculosis has infected one third of world's population and causes 8.8 million new cases with approximately 1.1 million deaths each year. A definitive diagnosis of TB can only be made by culturing Mycobacterium tuberculosis organisms from a specimen obtained from the patient. However diagnosing EPTB remains challenging because clinical samples obtained from relatively inaccessible sites may be paucibacillary, decreasing the sensitivity of diagnostic tests. The present study was initiated to determine the prevalence of Mycobacterium tuberculosis, Non Tuberculous Mycobacterium and its resistance to first line Anti-Tubercular drug from extra pulmonary samples. A total of 265 extra pulmonary samples were included in this study. All the samples screened by Zeihl-Neelsen AFB microscopy, were subjected to liquid culture using Mycobacterium Growth Indicator Tube (MGIT-320). Positive cultures were differentiated into Mycobacterium tuberculosis complex (MTBc) or Non-tubercular mycobacterium (NTM) by immunochromatography assay using MPT-64 antigen. Drug susceptibility testing of MTBc isolates done using MGIT-320. 32 MTBc and 7(NTM) grown in MGIT320 system were examined by the rapid MPT64 antigen detection. Among 32MTBc isolates 26 were sensitive to all the drugs and 6 were resistant to one or more drugs. Multiple drug resistant (MDR) isolates were 2. The susceptibility results were available within 11-13 days, thus within an average of 3 weeks of time complete results could be produced. We reported 6.6% prevalence of MDR-TB in EPTB at our tertiary care hospitals in southern India which is little lesser compared to other studies, reflecting better TB control programme. The prevalence of NTMs is also increasing, rising the importance of their recognition. }, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018g, title = {In vitro hemocompatability evaluation of gold nanoparticles capped with Lactobacillus plantarum derived lipase1}, author = {Imran Khan and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan and Ganesan Ramakrishnan and Jayati Ray Dutta}, url = {https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch189117}, doi = {10.3233/ch-189117}, issn = {1386-0291}, year = {2018}, date = {2018-05-04}, urldate = {2018-05-04}, journal = {Clinical Hemorheology and Microcirculation}, volume = {69}, issue = {1-2}, pages = {197-205}, publisher = {IOS Press}, abstract = {BACKGROUND:Gold nanoparticles (GNPs) are key diagnostic and therapeutic agents in biomedical sciences. Several studies have been carried out in different therapeutic areas such as in cancer treatment, antibacterial topical agents, imaging agents etc. There is a necessity to evaluate the gold nanoparticles cytotoxicity at all fronts. Since blood is the first point of contact in any therapy, it is required to have a thorough in vitro investigation of gold nanoparticles to avoid any adverse effects. OBJECTIVE:The objective of the current study is to evaluate the effect of gold nanoparticles capped with lipase on blood clotting factors, platelets, coagulation time and blood clotting strength. METHODS:Whole blood samples were drawn from healthy volunteers. Plasma and plasma with platelets were isolated from the blood and all the samples were treated with lipase capped gold nanoparticles, except control. Plasma fibrinogen formed in the blood coagulation process after contacting with nanoparticles was quantitatively evaluated. In addition, platelet aggregation, blood clotting kinetics, strength of the blood clot and time were evaluated post nanoparticle treatment. RESULTS:The work primarily explores the effect of GNPs on blood with changing concentrations of lipase capping. Plasma fibrinogen levels of plasma samples were found to be moderately elevated, however, there is no significant effect on blood clotting kinetics, strength, and platelet aggregation. Also, the study showed that lipase capped GNPs did not result in aggregation upon interaction with plasma components and remained stable for 1 hour after incubation. CONCLUSIONS:Our study revealed that lipase capped GNPs synthesized using NaBH4 approach were stable and hemocompatible. There is an increase in fibrinogen levels after the exposure to nanoparticles, an observation which is consistent with other studies. However, the functional consequences of such increase are unknown. The results of no significant platelet aggregation, change in blood clotting time, kinetics, and clot strength revealed the non-toxic effect of lipase capped GNPs towards blood components, which is essential for any in vivo applications.}, key = {pmid29630542}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Zaman_2018, title = {Clonal diversity and genetic profiling of antibiotic resistance among multidrug/carbapenem-resistant klebsiella pneumoniae isolates from a tertiary care hospital in Saudi Arabia}, author = {Taher Zaman and Maha Alrodayyan and Maha Albladi and Mohammed Aldrees and Mohammed Ismail Siddique and Sameera Aljohani and Hanan H. Balkhy}, url = {https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/s12879-018-3114-9.pdf}, doi = {10.1186/s12879-018-3114-9}, issn = {1471-2334}, year = {2018}, date = {2018-05-01}, urldate = {2018-05-01}, journal = {BMC Infectious Diseases}, volume = {18}, issue = {1}, pages = {1-11}, publisher = {Springer Science and Business Media LLC}, abstract = {Background: The nexus between resistance determinants, plasmid type, and clonality appears to play a crucial role in the dissemination and survival of carbapenem-resistant Klebsiella pneumoniae (CRKP). The incidence of infections involving CRKP in Saudi Arabia is increasing and there is a need for detailed molecular profiling of this pathogen for CRKP surveillance and control. Methods: The resistance determinants of 71 non-redundant CRKP isolates were investigated by polymerase chain reaction (PCR) and sequencing. Plasmid typing was performed using PCR-based replicon typing and the clonality of isolates was determined by multilocus sequence typing. Capsular polysaccharide synthesis genes and other virulence factors were examined using multiplex PCR. Diversity was calculated using DIVEIN, clonal relationship was determined using eBURST, and phylogenetic analysis was performed using SplitsTree4. Results: A polyclonal OXA-48 gene alone was the most common carbapenemase detected in 48/71 (67.6%) isolates followed by NDM-1 alone in 9/71 (12.7%) isolates. Coproduction of OXA-48 and NDM-1 was observed in 6/71 (8.5%) isolates. Both carbapenemase genes could be transferred into an Escherichia coli recipient. CTX-M-15 was the most abundant extended-spectrum β-lactamase gene detected in 47/71 (66.2%) isolates, whereas clone-specific CTX-M-14 (ST-199 and -709) was found in 15/71 (21%) isolates. Sixty-seven of 71 isolates were positive for one or more plasmid replicons. The replicons detected were: IncFII; IncFIIK; IncFIA; IncFIB; L/M; IncI1; and IncN. FIIK and L/M were predominant, with 69 and 67% positivity, respectively. All isolates were negative for the magA (K1), rmpA, and K2 genes and presented a non-hypermucoviscous phenotype. Conclusion: A polyclonal CRKP reservoir of sequence types (STs)-37, − 199, and − 152 was observed and ST-152 appeared to be a “frequent carrier” of the NDM-1 gene. ST-199, a singleton not previously reported, showed a sequence diversity suggestive of positive selection. A significant association was evident between resistance determinants and the clonal types of K. pneumoniae: all ST-152 isolates were positive for NDM-1 but negative for OXA-48; ST-199 isolates were positive for OXA-48 but negative for NDM-1; and ST-709 and -199 isolates were positive for CTX-M-14. The incidence of certain clonal types in large numbers predicts an outbreak-like situation and warrants stringent surveillance and infection control.}, key = {pmid29724185}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Shaikh_2018, title = {A study of biochemical changes among elderly attending a tertiary care center}, author = {Fawwad M. Shaikh and Mohammed Sarosh Ahmed and Suhasini D. and Tripti Deb}, url = {https://ijphrd.com/scripts/IJPHRD%20May%20%202018.pdf}, doi = {10.5958/0976-5506.2018.00412.6}, issn = {0976-0245}, year = {2018}, date = {2018-05-01}, urldate = {2018-05-01}, journal = {Indian Journal of Public Health Research and Development}, volume = {9}, issue = {5}, pages = {59-63}, abstract = {Introduction: This century has seen longevity as a silent revolution. With alarming rise in the population of the world; increasing from 5.7 billion in 1995 to reach a 10.8 billion by 2050. In India, the grey population just doubled in less than 25 years. During ageing there are lots of changes occurring in the body; more so in the biochemical parameters. Hence this study was planned to elucidate the pattern of changes among the elderly population attending a tertiary care hospital. Materials and method: A cross-sectional hospital record based study was conducted to elucidate the biochemical changes occurring in geriatric population, which included hundred patient records comprising of equal proportion of females and males above the age of 60 years. Results: The study participants had mean age of 64 + 2 years. The socio demographic features were that majority (93%) belonged to the class I & II according to the modified B. G. Prasad Classification. Majority (61%) were hypertensive, 40% were Diabetic, 40% were obese and few of them (1-2%) were found to have hypothyroidism, Gout and liver disorders. Females had significantly high amount of HDL cholesterol. The diabetics had low HDL, the Impaired Glucose Tolerance and hypertensive had high levels of triglycerides. Conclusion: Significantly high HDL levels were found in women and normal glucose tolerance individuals, high triglycerides were seen in individuals with Impaired Glucose Tolerance and hypertension. Larger studies are required to see the significance of this form of distribution. Regular health check-ups must be encouraged to see the age related changes in the various parameters to ascertain factors that have an impact on the healthy living of this vulnerable group of individuals}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2018, title = {Clinical outcomes of switching antiplatelet therapy from prasugrel to clopidogrel after 3-6 months of percutaneous coronary intervention with DES: a preliminary study}, author = {Shaheda Siddiqui and Rajashekar Reddy Gurrala and Hafsa Sania and Hafsah Hani and Maryam Shoukath and Madiha Nooreen and Vinod K. Unni and Parvaiz Kadloor}, url = {https://go.gale.com/ps/i.do?id=GALE%7CA573309377&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=&p=AONE&sw=w&userGroupName=anon%7Ec5a0bd07&aty=open-web-entry}, year = {2018}, date = {2018-04-30}, urldate = {2018-04-30}, journal = {Indian Heart Journal Interventions}, volume = {1}, issue = {1}, pages = {35-39}, abstract = {Introduction: Dual antiplatelet therapy comprising aspirin and a P2Y[sub]12-receptor inhibitor for 1 year is the recommended treatment for the prevention of recurrent thrombotic events in patients who have undergone percutaneous coronary intervention (PCI) with the implantation of drug-eluting stent (DES). Objectives: To assess the safety and efficacy of switching the subjects from prasugrel to clopidogrel after 3-6 months of PCI with DES. Materials and methods: It is a single-center, prospective study conducted in a tertiary care hospital. The study included 100 subjects who underwent PCI with DES using prasugrel as the initial antiplatelet agent along with aspirin. Between 3 and 6 months after PCI, the patients were switched from prasugrel to clopidogrel without a loading dose. These subjects were followed up at day 28 and day 90 after switch for adverse events. Results: The mean age of subjects was 52.58[+ or -]10.14 years. Of the total subjects, 59% were male and 41% were female. Approximately 53% subjects were switched after 3 months of PCI, whereas 47% were switched after 6 months. At day 28 and day 90 after switch, no major adverse cardiovascular events (including stent thrombosis) were reported. Only two episodes of minor bleeding were observed between day 28 and day 90. Conclusion: In this preliminary study, no major events, ischemic or bleeding, during the follow-up period after the subjects were switched from prasugrel to clopidogrel were reported. These findings suggest that switching the subjects from prasugrel to clopidogrel after 3-6 months of PCI may be safe and effective.}, keywords = {Cardiology, Deccan School of Pharmacy}, pubstate = {published}, tppubtype = {article} } @article{Neeluri_2018b, title = {Identification of an anthropometric surrogate to low birth weight in newborns: a hospital based cross sectional study}, author = {Rajesh Neeluri and Kiran Pamarthi }, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/2843/2037}, doi = {10.18203/2394-6040.ijcmph20181724}, issn = {2394-6032}, year = {2018}, date = {2018-04-24}, urldate = {2018-04-24}, journal = {International Journal of Community Medicine and Public Health}, volume = {5}, issue = {5}, pages = {2066-2071}, abstract = {Background: Low birth weight babies have less chances of survival during first year of life.Appropriate and timely care of a newborn especially if he is born with low birth weight is important but this is difficult in developing countries. There is a need to develop simple, inexpensive and practical methods to identify low birth weight newborns soon after birth. Methods: A hospital based Cross sectional study was carried out on 965 live born neonates who were born during one year period. All the anthropometric measurements are taken within 24 hours of birth. Pearson’s correlation was done to assess correlation of various anthropometric parameters with birth weight. Results: Out of 965 live born neonates, 510 (52.8%) were male babies and 455 (47.2%) were female babies. 289 (29.9%) babies had birth weight less than 2500 gms. The highest correlation among all measurements was observed between birth weight and mid arm circumference while the least correlation was between birth weight and crown heel length. AUC value for ROC curves is highest for Mid arm circumference (0.917) which shows that it is a better surrogate predictor of low birth weight (<2500 gms) in our study as compared to other anthropometric parameters. Conclusions: Measurement of mid arm circumference is easier, convenient and statistically superior to other anthropometrical parameters in detection of low birth weight newborn babies.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Zafer_2018, title = {A study of serious adverse drug reactions with antiepileptic drugs: a pharmacovigilance study}, author = {Shaima Zafer and Mohammed Abid Ali and Ghulam Subhani and T. Ushashree }, url = {https://www.ijbcp.com/index.php/ijbcp/article/view/2441/1914}, doi = {10.18203/2319-2003.ijbcp20181636}, issn = {2279-0780}, year = {2018}, date = {2018-04-23}, urldate = {2018-04-23}, journal = {International Journal of Basic & Clinical Pharmacology}, volume = {7}, issue = {5}, pages = {922-925}, abstract = {Background: Approximately 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally. There are currently more than 25 drugs in the market for the treatment of epilepsy, many of which have similar efficacy but differ in their tolerability profile. Besides unmatched beneficial potential of antiepileptic drugs, it is associated with many adverse reactions too. This study aims to identify the serious adverse reactions caused by prescribed antiepileptics, reported at the pharmacovigilance centre of government tertiary care centre. Methods: This is a retrospective, pharmacovigilance study of the antiepileptic drugs adverse reactions reported over a period of 1 year at a tertiary care centre. Results: A total of 120 ADRs of antiepileptic drugs were reported and collected at the pharmacovigilance centre. According to the WHO-ART system organ classification of ADRs, 78% of ADRs belonged to skin and appendages disorder. Based on the modified Hartwig and Siegel scale of severity, 60.8% ADRs were mild, 18.5% were moderate and 20.8 % were severe ADRs. The severe ADRs included: Steven-Johnson syndrome, Toxic epidermal necrolysis, Erythroderma, DRESS syndrome and Acute pancreatitis. Phenytoin has been found to be the antiepileptic drug causing the most number of severe ADRs amongst the prescribed antiepileptics. According to the modified Schumock and Thornton criteria most of the severe ADRs were not preventable. Conclusions: This study analyses the ADRs associated with antiepileptics reported at the pharmacovigilance centre. 20.8% ADRS were severe, this indicates that the epileptic patients should be closely monitored for ADRs, to avoid clinically significant harmful consequences. The awareness of ADRs would help physicians to identify patients with greater risk of ADRs and therefore, might benefit from ADRs monitoring and reporting programmes.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Mustafa_2018, title = {A study of TORCH screening in women with bad obstetric history}, author = {Maimoona Mustafa and Qursheed Sultana and Nazima Begum and Madiha Nooreen and Shafia Fatima}, url = {https://www.ijcmas.com/7-4-2018/Maimoona%20Mustafa,%20et%20al.pdf}, doi = {10.20546/ijcmas.2018.704.245}, issn = {2319-7692}, year = {2018}, date = {2018-04-10}, urldate = {2018-04-10}, journal = {International Journal of Current Microbiology and Applied Sciences}, volume = {7}, issue = {4}, pages = {2155-2160}, abstract = {Maternal infections have been considered as one of the significant factors in the causation of bad obstetric history. Infections caused by Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex virus are benign. However, they may lead to serious complications, especially when they are acquired during the first trimester of pregnancy. These are associated with inadvertent outcomes like multiple abortions, intra-uterine fetal death, still-births and congenital malformations. Data regarding the detection of these infections is scanty as the risk requirement of expensive commercial diagnostic kit- Toxoplasma, Rubella, Cytomegalovirus and Herpes simplex IgM antibodies. This study was undertaken to assess the utility in pregnant women with bad obstetric history. The present study was undertaken as the case-control study at Princess Esra Hospital, Hyderabad between January 2015 and December 2017. A total of 50 pregnant women of age range in their first trimester attending Ante Nata Clinic were included along with 35 age matched control pregnant women with no bad obstetric history. After obtaining the institutional ethics committee approval serum samples were obtained aseptically from the enrolled cases and were tested for the identification of specific IgM antibodies for Toxoplasma, Rubella, Cytomegalovirus and Herpes using sandwich and capture ELIZA (Calbiotech lab USA). The assay was performed according to the manufacturer’s instructions and the results were calculated in MS excel and test of proportion and Pearson’s Chi square test. 23 women for IgM antibodies Toxoplasma, Rubella, Cytomegalovirus and Herpes either alone or in combination were identified in the group I. In the control group (Group II), IgM antibodies were detected in 11 cases. When compared with the control group, Rubella and Toxoplasma infection were found to have statistically significant difference with the p-value of 0.016 and 0.026 respectively. However, there was no statistically significant difference found between the two study groups. Detection of IgM antibodies performed reflects recent infection and there is high prevalence of infection caused by TORCH agents in women with bad obstetric history compared to healthy controls. Hence, all the anti-natal cases with bad obstetric history should be routinely screened as IgM antibodies detection is a reliable indicator of maternal infections and can be used as a screening test.}, keywords = {Deccan School of Pharmacy, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2018b, title = {Early enteral nutrition in neonates following abdominal surgery}, author = {G. Raghavendra Prasad and J. V. Subba Rao and Amtul Aziz and T. M. Rashmi and Saniya Ahmed}, url = {https://www.jneonatalsurg.com/ojs/index.php/jns/article/view/384/pdf}, doi = {10.21699/jns.v7i2.740}, issn = {2226-0439}, year = {2018}, date = {2018-04-08}, urldate = {2018-04-08}, journal = {Journal of Neonatal Surgery}, volume = {7}, issue = {2}, pages = {21}, abstract = {Introduction: Nil per oral (NPO)/nil by mouth has been the most commonly practiced convention in post-operative period. Misplaced fear of aspiration led to routine prescription of “NPO.” Starvation leads to atrophy of the gut mucosa leading to decreased barrier effect of gut mucosa. This starvation-induced gut mucosal injury increases septic complications and mortality. The study aims at establishing the feasibility and effect of early enteral nutrition (EEN) in neonates following abdominal surgeries. Materials and Methods: A total of 260 cases formed the cohort of prospective cohort study, 79 in EEN - Group “A” and 181 in NPO - Group “B.” Effect of EEN was evaluated with regard to outcome, hospital stay, surgical site infections (SSI), stress markers such as C-reactive protein (CRP), procalcitonin, tumor necrosis factor alpha (TNF α), and neonatal-predisposition, insult/injury, response, organ failure (Neo-PIRO) scores, intra-abdominal pressure (IAP) grade, tolerance of feeds, and time to first stool. Chi-square was the statistical method used. Epi info version 7 was the software used. Results: Group B had higher mortality (20.09%) than Group A (P < 0.05). 33.7 in Group B developed SSI, of which 90% were deep and intracavitary (P < 0.05). Hospital stay was less in Group A (P < 0.05). CRP and Neo-PIRO scores were less in Group A compared to Group B (P < 0.05). TNF-α expression and IAP scores were not statistically significant (P > 0.05). Procalcitonin levels were higher in Group B. Feeds were better tolerated in Group A. First stool appeared earlier in Group A than B. There was no difference in anastomotic leak in both the groups. Conclusion: EEN in neonates following abdominal surgeries is feasible, well tolerated reduces the hospital stay and mortality, and reduces SSIs, and early gut motility could be established.}, keywords = {Anesthesiology, General Surgery, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ali_2018b, title = {Prevalence of non-insulin-dependent diabetes mellitus among patients with cholelithiasis: a single-centered, cross-sectional study}, author = {Sidra Ali and Shaik Tanveer Ahamad and Abdul Subhan Talpur and Shreeya Parajuli and Jawad Farooq}, url = {https://www.cureus.com/articles/11178-prevalence-of-non-insulin-dependent-diabetes-mellitus-among-patients-with-cholelithiasis-a-single-centered-cross-sectional-study#!/}, doi = {10.7759/cureus.2444}, issn = {2168-8184}, year = {2018}, date = {2018-04-07}, urldate = {2018-04-07}, journal = {Cureus}, volume = {10}, issue = {4}, pages = {e2444}, publisher = {Cureus, Inc.}, abstract = {Introduction: Gallstone disease (GD) is one of the major causes of morbidity and mortality in the west and most of the countries worldwide. Cholelithiasis and diseases of the biliary tract are becoming more prevalent with the socioeconomic burden in developing countries like Pakistan. GD is a chronic, recurrent hepatobiliary disease, the basis of which is the impaired metabolism of cholesterol, bilirubin, and bile acids, which is characterized by the formation of gallstones in the hepatic bile duct, common bile duct, or gallbladder. Epidemiologic studies have shown that individuals with diabetes have a higher risk of cholelithiasis but only a few studies have been done in Pakistan to establish the association so far. Hence, the aim of the present study is to establish the association between diabetes and gallstone disease. Methods: A cross-sectional study was conducted at Liaquat University Civil Hospital, Hyderabad, Pakistan, between February 2017 and August 2017. Patients between the ages of 10 and 70 from either sex, who were diagnosed with cholelithiasis were included in this study whereas those patients who underwent cholecystectomy previously were excluded. Diabetic cases were identified based on fasting glucose levels (FGL) and the serum levels of HbA1c. An interview-based questionnaire was employed to collect the patient's demographic profile and risk factors by the students. Informed consent was taken from all the study subjects and the confidentiality of the data was ensured. Results: From the sample size of patients evaluated (a total of 204), based on investigative studies performed, 74 cholelithiatic patients (36.6%) were found to concurrently have diabetes as well. Among the 74 patients with both cholelithiasis and diabetes type-2 (NIDDM), 56 were female and 18 were males. The rest of the patients with cholelithiasis were found to be non-diabetic (78 were males and 52 female). The majority of the GD patients (51 (25 males and 26 females)) in the study sample was in the 50-60 age group. The mean age of the patients was 43 ± 12.1. In this study, we measured the fasting glucose levels (FGL). According to World Health Organization (WHO) and American Diabetes Association (ADA) criteria, we categorized 85 of the GD patients to be non-diabetic with serum fasting glucose levels between 70 and 100 gm/dL, and 45 patients were categorized to be in the pre-diabetic group with FGL levels between 100 and 126. Out of the 204 samples with GD, we found that 74 patients have diabetes, with serum FGL >126mg/dL. We measured HbA1c from each individual in the study sample. It was found that 79 patients had HbA1c levels <5.5, they are categorised as non-diabetic according to WHO and ADA criteria, 51 patients had values between 5.5 and 6.5 (pre-diabetic), and 35 GD patients had HbA1c values between 6.5 and 7.5 (categorized as diabetics with good control) and 39 patients with HbA1c above 7.5 (diabetes with poor control). Conclusion: In this study, we concluded that there is a higher prevalence of NIDDM in GD patients and there is an association between GD and NIDDM. This study also reiterated the association between obesity and GD. Female sex and advancing age also contribute to the formation of cholelethiasis. Cigarette smoking and alcohol consumption further worsen cholelithiasis but are not established primary risk factors.}, key = {pmid29888148}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Battu_2018, title = {Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy}, author = {Srikanth Battu and Sumbul Afroz and Jeevan Giddaluru and Saima Naz and Weishan Huang and Saratchandra Singh Khumukcham and Rafiq Ahmad Khan and Saleem Yousuf Bhat and Insaf Ahmed Qureshi and Bramanandam Manavathi and Aleem Ahmed Khan and Avery August and Seyed Ehtesham Hasnain and Nooruddin Khan}, editor = {Douglas Green}, url = {https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005317&type=printable}, doi = {10.1371/journal.pbio.2005317}, issn = {1545-7885}, year = {2018}, date = {2018-04-05}, urldate = {2018-04-05}, journal = {PLOS Biology}, volume = {16}, issue = {4}, pages = {e2005317}, publisher = {Public Library of Science (PLoS)}, abstract = {Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1β (IL-1β) and provides protection from intestinal inflammation in mice. HF inhibits IL-1β through general control nonderepressible 2 kinase (GCN2)–dependent activation of the cytoprotective integrated stress response (ISR) pathway, resulting in rerouting of IL-1β mRNA from translationally active polysomes to inactive ribocluster complexes—such as stress granules (SGs)—via recruitment of RNA-binding proteins (RBPs) T cell–restricted intracellular antigen-1(TIA-1)/TIA-1–related (TIAR), which are further cleared through induction of autophagy. GCN2 ablation resulted in reduced autophagy and SG formation, which is inversely correlated with IL-1β production. Furthermore, HF diminishes inflammasome activation through suppression of reactive oxygen species (ROS) production. Our study unveils a novel mechanism by which IL-1β is regulated by AAR and further suggests that administration of HF might offer an effective therapeutic intervention against inflammatory diseases.}, key = {pmid29621237}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Morra_2018, title = {Clinical outcomes of current medical approaches for Middle East respiratory syndrome: a systematic review and meta-analysis}, author = {Mostafa Ebraheem Morra and Le Van Thanh and Mohamed Gomaa Kamel and Ahmed Abdelmotaleb Ghazy and Ahmed M. A. Altibi and Lu Minh Dat and Tran Ngoc Xuan Thy and Nguyen Lam Vuong and Mostafa Reda Mostafa and Sarah Ibrahim Ahmed and Sahar Samy Elabd and Samreen Fathima and Tran Le Huy Vu and Ali S. Omrani and Ziad A. Memish and Kenji Hirayama and Nguyen Tien Huy}, url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/rmv.1977}, doi = {10.1002/rmv.1977}, issn = {1052-9276}, year = {2018}, date = {2018-04-01}, urldate = {2018-04-01}, journal = {Reviews in Medical Virology}, volume = {28}, issue = {3}, pages = {1-9}, publisher = {Wiley}, abstract = {Middle East respiratory syndrome (MERS) is a respiratory disease caused by MERS coronavirus. Because of lack of vaccination, various studies investigated the therapeutic efficacy of antiviral drugs and supportive remedies. A systematic literature search from 10 databases was conducted and screened for relevant articles. Studies reporting information about the treatment of MERS coronavirus infection were extracted and analyzed. Despite receiving treatment with ribavirin plus IFN, the case fatality rate was as high as 71% in the IFN-treatment group and exactly the same in patients who received supportive treatment only. Having chronic renal disease, diabetes mellitus and hypertension increased the risk of mortality (P < .05), and chronic renal disease is the best parameter to predict the mortality. The mean of survival days from onset of illness to death was 46.6 (95% CI, 30.5-62.6) for the IFN group compared with 18.8 (95% CI, 10.3-27.4) for the supportive-only group (P = .001). Delay in starting treatment, older age group, and preexisting comorbidities are associated with worse outcomes. In conclusion, there is no difference between IFN treatment and supportive treatment for MERS patients in terms of mortality. However, ribavirin and IFN combination might have efficacious effects with timely administration and monitoring of adverse events. Large-scale prospective randomized studies are required to assess the role of antiviral drugs for the treatment of this high mortality infection.}, key = {pmid29664167}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Sayeed_2018, title = {Immediate and delayed effect of Ramadan fasting on spirometry parameters}, author = {Adiba Sayeed and Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin}, url = {https://amphysiol.com/index.php/amp/article/view/v2i1.279619}, doi = {10.23921/amp.2018v2i1.279619}, issn = {2456-8422}, year = {2018}, date = {2018-03-31}, urldate = {2018-03-31}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {1}, pages = {7-10}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, abstract = {Fasting in the month of Ramadan is an obligatory duty for muslims. Researchers have investigated health benefits of fasting and reported conflicting results. The purpose of this study was to determine the immediate and delayed effects of Ramadan fasting on spirometric parameters. 50 apparently healthy young adults aged between 17-27 years, belonging to both genders who fast during the month of Ramadan were enrolled for the study. Spirometric recordings were done at three different time points. First: 5-10 days before the start of Ramadan (Pre-Ramadan); second: within 10 days of the beginning of Ramadan fasting (Ramadan); third: within 7 days of the end of Ramadan (Post-Ramadan). There were no statistically significant differences between the three phases with respect to tidal volume (TV), inspiratory reserve volume (IRV), expiratory reserve volume (ERV), forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), FEV1/FVC, peak expiratory flow rate (PEFR) and forced expiratory flow 25% to 75% (FEF25-27). To conclude, Ramadan fasting does not have any significant effect on pulmonary function tests as assessed by spirometry. Hence, the diagnosis and prognosis of a respiratory disorder made on spirometry findings are reliable and need no error correction if an individual is fasting.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2018, title = {Target with-in target}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v2i1.275951}, doi = {10.23921/amp.2018v2i1.275951}, issn = {2456-8422}, year = {2018}, date = {2018-03-31}, urldate = {2018-03-31}, journal = {Annals of Medical Physiology}, volume = {2}, issue = {1}, pages = {1-2}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018c, title = {Riedel's thyroiditis presenting as large retropharyngeal goitre-a rare case}, author = {Bushra Khan and Ganji Ravi and Bhima Linga Prasad}, url = {https://www.apjhs.com/index.php/apjhs/article/view/886/773}, doi = {10.21276/apjhs.2018.5.1.33}, issn = {2349-0659}, year = {2018}, date = {2018-03-30}, urldate = {2018-03-30}, journal = {Asian Pacific Journal of Health Sciences}, volume = {5}, issue = {1}, pages = {150-152}, abstract = {The thyroid gland lies in the anterior triangle of the neck in close approximation to the larynx and the trachea. The extension of an enlarged thyroid gland outside the normal confines of the thyroid bed is well known. A 35-year-old woman presented with a 12-year history of swelling in the midline of the neck which progressively increased in size and was currently associated with symptoms of dysphagia, difficulty in breathing, and hoarseness of voice. Physical examination revealed an ill-defined neck swelling moving on deglutition, with a bosselated surface with no overlying skin changes. Contrast-enhanced computed tomography scan of the neck revealed para- and retro-pharyngeal goiter with extension up to base of the tongue. Retropharyngeal extension of goiter is thought to be a rare entity in itself as shown in literature, but a large retropharyngeal goiter in Riedel’s thyroiditis has not been described before and seems to depend mainly on the body habitus of the patient.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2018, title = {A clinico-aetiopathological study of palmoplantar keratoderma}, author = {Fatima Razvi and Nayeem Sadath Haneef and V. Sriteja and Chudi Kavya Reddy and Fatima Ummul Hasnath and Ramesh Bang}, url = {https://jemds.com/data_pdf/1_Nayeem,%20Iss%2013,%20Mar%2026,.pdf}, doi = {10.14260/jemds/2018/367}, issn = {2278-4748}, year = {2018}, date = {2018-03-26}, urldate = {2018-03-26}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {7}, issue = {13}, pages = {6808-6812}, abstract = {BACKGROUND: Palmoplantar keratodermas (PPKs) are a diverse entity of disorders that are characterised by abnormal thickening of the skin on the palms and soles. Over 50 types have been described and many of the inheritable types have been well documented in a review article by Itin and Fistarol. There is a considerable overlap and variation in clinical and histopathological feature of these conditions. Thus, a clinicopathological correlation is required for appropriate diagnosis. This would help in a better management of patients. Aims and Objectives- To study the various aetiological factors causing palmoplantar keratoderma (PPK), to study the histopathological features of various types of palmoplantar keratoderma (PPK). MATERIALS AND METHODS: Hundred (100) consecutive patients of palmoplantar keratoderma fulfilling the inclusion criteria, attending the outpatient Department of Dermatology, STD and leprosy, at the tertiary care centre of our medical college. After detailed history complete general, systemic and cutaneous examination was done with reference to lesions on the other parts of the body, any other dermatoses or systemic diseases. Skin biopsy was done in all the patients. Routine investigations like complete blood picture, complete urine examination, random blood sugar, serum creatinine and other tests like thyroid profile, VDRL, HIV 1 and 2 antibodies, potassium hydroxide mount of skin scrapings and PAS staining of biopsy section were done wherever necessary. Settings and Design- An observational study. RESULTS: Patient’s age ranged from 8 to 70 years (mean age being 31). Common age group was 11 - 20 years (24.00 %) followed by 21 - 30 years (22.00%), 31 - 40 years (20%), 41 - 50 years (14%), < 10 years (8%), 51 - 60 years (6%) and 61 - 70 years (6%), not seen between 71 - 80 years. Out of the total 100 patients studied, 44.00% were male and 56.00% were female patients. Male-to-female ratio was 0.78 showing female preponderance. Occurrence of PPK was seen among manual labourers (28.00%), students (20.00%), housewives (16.00%) and agricultural workers (10.00%). Involvement of palms and soles was seen in 48.0% followed by soles 28.0% and palms in 24%. Clinically, 34% patients were diagnosed by psoriasis, 26% eczema, 10% HPPK, 8% pityriasis rubra pilaris, 8% with atopic dermatitis and 2% patients with drug-induced keratoderma and 10% patients with hereditary palmoplantar keratoderma. Histopathologically, out of 34 clinically diagnosed psoriasis 24 showed typical changes, while 18 out of 26 patients showed changes of eczema. All 6 clinically diagnosed patients showed typical changes of lichen planus. All 8 clinically diagnosed patients showed typical changes of Pityriasis rubra pilaris. CONCLUSION: The present study documented higher prevalence of palmoplantar keratoderma in the patients of age group 11 - 20 years with female preponderance. Psoriasis was more common among males and eczemas was more common in females.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Shabbeer_2018, title = {The role of renal ultrasound in children with febrile urinary tract infections}, author = {Shabbeer and Mohammed Nizamuddin}, url = {https://www.theijcp.org/index.php/ijcp/article/view/301/244}, doi = {10.14740/ijcp295e}, issn = {1927-1255}, year = {2018}, date = {2018-03-15}, urldate = {2018-03-15}, journal = {International Journal of Clinical Pediatrics}, volume = {7}, issue = {1-2}, pages = {6-12}, abstract = {Background: This study was designed to examine the capability of renal ultrasonography (US) for predicting vesicoureteral reflux (VUR) and renal scarring (RS), and to assess, using initial US, the significant urologic abnormalities that impact on management of children hospitalized with the first febrile urinary tract infection (UTI). Methods: Hospitalized children aged ≤ 2 years with the first febrile UTI were prospectively evaluated using imaging studies, including 99mTc dimercaptosuccinic acid (DMSA) scan, US, and voiding cystourethrography. Results: Of the 310 children analyzed (195 boys and 115 girls), 105 (33.9%) had abnormal US. Acute DMSA scans were abnormal in 194 children (62.6%), including 89 (45.9%) with concomitant abnormal US. There was VUR in 107 children (34.5%), including 79 (25.5%) with grades III-V VUR. The sensitivity and negative predictive values of US were 52.3% and 75.1%, respectively, for grades I-V VUR; and 68.4% and 87.8%, respectively, for grades III-V VUR. Eighty-five children (27.4%) had RS, including 55 (64.7%) with abnormal US. Of the 105 children with abnormal US, 33 (31.4%) needed subsequent management (surgical intervention, parental counseling, or follow-up of renal function). Nephromegaly on initial US and grades III-V VUR were risk factors of RS. Conclusions: Abnormal US may carry a higher probability of grades III-V VUR and RS, and can affect subsequent management in a significant number of children. Nephromegaly on initial US and grades III-V VUR are strongly associated with an increased risk for RS. Thus, US should be performed on children after the first febrile UTI and children with normal US may not require voiding cystourethrography.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Zafer_2018b, title = {E-learning in medical education-a cross sectional study in a medical college}, author = {Shaima Zafer and Ghulam Subhani and Raheem Fatima and Humaira Fatima}, url = {http://jmscr.igmpublication.org/v6-i3/100%20jmscr.pdf}, doi = {10.18535/jmscr/v6i3.100}, issn = {2347-176X}, year = {2018}, date = {2018-03-01}, urldate = {2018-03-01}, journal = {Journal of Medical Science and Clinical Research}, volume = {6}, issue = {3}, pages = {604-607}, abstract = {Introduction: Medical education is acquiring knowledge and skills for ensuring the quality of health protection .Qualitative and quantitative studies of collaborative learning in medicine have shown higher levels of learner satisfaction, self awareness, improvement in knowledge and understanding of concepts. E-learning when combined effectively with quality professional teaching may achieve the goal of complete education. Methodology: A Prospective, cross-sectional, structured questionnaire based study was conducted among 300 medical students in a medical college. Result: A questionnaire study was conducted among the students of medical sciences. 76% students had access to internet.70% use internet for e-learning. 68% find e-learning helpful.56% watch educational videos, 42% refer to online books, 74 % are Wikipedia users. 62 % find online teaching session interesting.68% find e-leaning better then didactic teaching. 66% preferred e-learning in combination with classroom lectures where as 20 % preferred classroom lectures and 14 % preferred e-learning alone. 78% want e-learning to be applied in education. Conclusion: E-learning and technology are creating the groundwork for a revolution in education. E-learning therefore should be incorporated and explored further in the medical education system of India. }, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2018, title = {A study of fingerprints in relation with gender and blood group among medical students in Hyderabad, India}, author = {Khazi Mudabbir Ahmed and Iqbal Banu Hussain and Sultan Rizwan Ahmad}, url = {https://www.ijfmt.com/scripts/IJFMT%20Jan-Mar%202018.pdf}, doi = {10.5958/0973-9130.2018.00047.6}, issn = {0973-9122}, year = {2018}, date = {2018-03-01}, journal = {Indian Journal of Forensic Medicine & Toxicology}, volume = {12}, issue = {1}, pages = {240-243}, abstract = {Back ground: Finger print identification is undoubtedly the most reliable and acceptable evidence till date in the court of law. Fingerprints can be used to identify an unknown victim, witness, or a suspect. Therefore, an attempt has been made to study the association of fingerprint pattern with gender & blood group. Methodology: A cross sectional study was conducted among the medical students of MBBS of either gender. A total of 176 students were participated in study. Finger prints were taken on white paper and blood group were also noted on same paper. Data were analyzed as frequency and chi square test. Results: Loops were the most common fingerprint pattern. B+ve and A+ve were common blood group. Association between loops with Blood group A+ve and of whorls and arched with B+ve was found to be statistically significant. Conclusion: Knowledge of finger pattern could help in the prediction of blood group in medico-legal investigations. }, keywords = {Community Medicine, Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2018b, title = {Study of road traffic accident cases attending tertiary care hospital in Hyderabad, India}, author = {Khazi Mudabbir Ahmed and Iqbal Banu Hussain and Sultan Rizwan Ahmad}, url = {https://www.ijfmt.com/scripts/IJFMT%20Jan-Mar%202018.pdf}, doi = {10.5958/0973-9130.2018.00048.8}, issn = {0973-9122}, year = {2018}, date = {2018-03-01}, urldate = {2018-03-01}, journal = {Indian Journal of Forensic Medicine & Toxicology}, volume = {12}, issue = {1}, pages = {244-247}, abstract = {Background: Road traffic accidents ( RTA) is an important cause of death among young people in India. Cost of treatment or death of young people cause considerable economic losses to victims and their families. Objectives: The purpose of this study was to study the characteristics of injuries from road traffic accidents in Hyderabad, India. Methodology: A study was conducted from January 2016 to June 2016 in Owaisi Hospital of Deccan College of Medical Sciences, Hyderabad. Data was collected on cases admitted due to RTA in Emergency Department of Owaisi Hospital. A total of 204 RTA cases were studied from the case records of the medical records section admitted during study period. The information collected consists of personal identification data, time, date, place, and type of injury, vehicles involved in RTA. Results: In this study 76.4% were males, common age group involved was of 20-39 years. Motorcyclists were 63% among population involved in RTA. Accidents were more on weekends. 70% of injuries were in both limbs. Conclusions: Most of the victims of road traffic accidents were young males and Motorcycle was common vehicle involved in accident.}, keywords = {Community Medicine, Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Nepal_2018b, title = {Lifestyle practices and obesity in Nepalese youth: a cross-sectional study}, author = {Gaurav Nepal and Eans T. Tuladhar and Saurav Dahal and Shaik Tanveer Ahamad and Sumikshya Adhikari and Apsara Kandel}, url = {https://www.cureus.com/articles/10708-lifestyle-practices-and-obesity-in-nepalese-youth-a-cross-sectional-study#!/}, doi = {10.7759/cureus.2209}, issn = {2168-8184}, year = {2018}, date = {2018-02-20}, urldate = {2018-02-01}, journal = {Cureus}, volume = {10}, issue = {2}, pages = {e2209}, publisher = {Cureus, Inc.}, abstract = {Introduction: Understanding the lifestyle factors associated with obesity is critical to create a successful intervention that would prevent or reduce the obesity beforehand. However, these factors have not been assessed among Nepalese youths thus far. This study aims to determine the prevalence of obesity and to explore the potential lifestyle risk factors in young university students of Nepal. Methods: We included in the study 384 young students aged between 17 and 24 years, pursuing medicine at Tribhuvan University, Institute of Medicine, in this cross-sectional study. A self-administered questionnaire to collect information about age, sex, smoking, alcohol consumption, meat consumption, fast-food consumption, and sedentary lifestyle was employed. Anthropometric measurements were taken to calculate body mass index (BMI) and waist-to-hip ratio (WHR). Results: This study revealed that the current, episodic heavy alcohol consumers, current cigarette smokers, and individuals with a sedentary lifestyle had a statistically significant higher BMI and WHR as compared to age and gender-matched healthy subjects. Meat consumers as well had a statistically significant higher BMI. However, there has been no statistically significant difference in BMI and WHR in those who consume fast food from those who don’t. Conclusion: Our study shows a high prevalence of obesity among young university students of Nepal, making it necessary to develop effective preventive measures to reduce their exposure to the risk factors associated with obesity. Early interventions to encourage lifestyle changes can be a worthwhile and effective strategy to prevent and/or reduce the risks for the development of cardiovascular diseases (CVD) and other comorbidities.}, key = {pmid29686951}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Mohammedi_2018, title = {Effect of nicotine on platelet function}, author = {Fariha Mohammedi and Mohammed Abdul Hannan Hazari and Farisa Khatoon and Kazi Husna Abdul Naeem and Syed Imran Ali}, url = {https://www.medpulse.in/Physiology/html_5_2_2.php}, doi = {10.26611/103522}, issn = {2550-7613}, year = {2018}, date = {2018-02-10}, urldate = {2017-02-28}, journal = {MedPulse International Journal of Physiology}, volume = {5}, issue = {2}, pages = {13-16}, publisher = {MedPulse Publishing Corporation}, abstract = {Background: Tobacco is the dried and processed leaves of the plant Nicotiana tobacum that is widely cultivated and commercially grown in many countries of the world. In India, tobacco is taken in several other forms also, for example, Pan (betel quid), dried leaves (Patti), paste (Qiwam, Zarda), tobacco with lime (Khaini/Mawa). Its use is common in various parts of the world, including India and central Asia. An increase in the consumption of tobacco has been noticed among high school students, college students, and sports persons .This is immensely popular in all socio-economic states in India. It is viewed as especially ominous because of the ease , low expense of procurement, youth appeal, convenient shelf life and lack of social stigma. Despite the known health consequences of tobacco chewing‖ is not viewed by users as particularly dangerous and is considered less of a ―social evil‖ than smoking by much of the public. Previous reports have described long-term harmful effects of nicotine on various body parameters.. In view of the various pharmacological actions of nicotine and additives and the wide use in many regions and countries, chronic consumption may affect the status of hematological parameters and further delineate the effects of tobacco use to health. The effect of smokeless tobacco use on health irrespective of the mode of consumption has been well documented. Objective: this study was conducted to determine hematological effects of nicotine on platelet count and its functions. Materials and Methods: This cross sectional study was done in the department of internal medicine Owaisi Hospital and Research Centre. A detailed assessment was done on 200 apparently healthy subjects, out of which 100 were tobacco chewers and 100 non chewers. Various parameters were recorded which include personal details, department of work, history of smoking , chewing tobacco, history of exposure to tobacco smoke, history of any chronic disease like diabetes mellitus and medication history. Hematological investigations done. Automated blood analyzer was used for estimation of platelet count Results: In tobacco chewers the following platelet parameters are higher than non-chewers. 1. Platelet count -Statistically significant. 2. PCT- not significant statistically.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Nepal_2018, title = {Tenecteplase versus alteplase for the management of acute ischemic stroke in a low-income country–Nepal: cost, efficacy, and safety}, author = {Gaurav Nepal and Ghanshyam Kharel and Shaik Tanveer Ahamad and Babin Basnet}, url = {https://www.cureus.com/articles/10887-tenecteplase-versus-alteplase-for-the-management-of-acute-ischemic-stroke-in-a-low-income-country-nepal-cost-efficacy-and-safety#!/}, doi = {10.7759/cureus.2178}, issn = {2168-8184}, year = {2018}, date = {2018-02-09}, urldate = {2018-02-01}, journal = {Cureus}, volume = {10}, issue = {2}, pages = {e2178}, publisher = {Cureus, Inc.}, abstract = {Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered, mutant tissue plasminogen activator, is an alternative thrombolytic agent. The economic feasibility of stroke treatment has been a matter of huge debate and discussion thus far. The use of thrombolytics for the management of ischemic stroke has recently begun in Nepal. In low-income countries like Nepal, where the per capita income falls at just $691.7 and 25.2% of the population are under the poverty line, stroke patients cannot meet treatment expenses. Tenecteplase is easily available (for the management of acute coronary syndrome) in tertiary-level hospitals of Nepal and the price quote of tenecteplase ($450) is half the price of alteplase ($1000). In emergency cases, sometimes, the cost of alteplase can be greater than the patient can afford and they can't undergo thrombolysis even after arriving on time. However, evidence exists that supports the use of other alternatives (tenecteplase), which are also effective in the management of acute ischemic stroke. In this article, we examined current evidence for the efficacy and safety of tenecteplase when compared to alteplase. This review will make neurologists in Nepal familiar with the efficacy and safety of tenecteplase in comparison with alteplase since it is common for patients to not be able to afford the expensive alteplase, which makes guideline-based practice impossible some times.}, key = {pmid29651371}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018f, title = {Role of drug transporters and heat shock proteins during ethanol exposure to human neural precursor cells and its lineages}, author = {Sandeep Kumar Vishwakarma and Nusrath Fathima and Chandrakala Lakkireddy and Nagarapu Raju and Avinash Bardia and Sandhya Annamaneni and Syed Ameer Basha Paspala and Vishnupriya Satti and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0040816617302999?via%3Dihub}, doi = {10.1016/j.tice.2018.02.001}, issn = {0040-8166}, year = {2018}, date = {2018-02-07}, urldate = {2018-02-07}, journal = {Tissue and Cell}, volume = {51}, pages = {14-23}, publisher = {Elsevier BV}, abstract = {Introduction: Ethanol exposure to developing brain may alter the growth and differentiation of neurological cells resulting in unfavorable pathologies. Earlier studies have provided very limited mechanistic insights of cellular and molecular mechanisms which do not mimic with human situation due to varying cell types and poses potential challenges for investigation. Therefore, the present study was undertaken to evaluate the role of ABC transporters and heat shock proteins mediated response in human neural precursor cells (NPCs) and its lineages during proliferation and lineage differentiation against ethanol exposure. Methods: Effect of ethanol exposure was examined for neuronal cell survival and variation in cellular phenotype during neurospheres development and lineage differentiation. Generation of reactive oxygen species, and variation in cell cycle was identified along with transcriptional profiling for pluripotent markers (Nestin, NCAM, Sox-2, and Notch-2), drug transporters (ABCB1 and ABCG2) and stress protein (HSP70) during ethanol exposure. Results: ABC transporters as well as HSP70 mRNA expression was higher during proliferation as compared to differentiation with chronic ethanol (1 M) exposure (p < 0.01). Ethanol exposure resulted in higher variability in size and shape of developing neurospheres and decreased ability to form new neurosphere colonies. Significant changes were observed in dendrite development due to late ethanol exposure (p < 0.0001). Conclusion: The present study demonstrated significant role of ABC transporters and HSP70 proteins in providing defense against ethanol-induced damage in human neurological cells. However, the over-expression of ABC transporter and HSP-70 proteins during such pathological conditions do not provide complete defense and additional strategies are required to repair the damage.}, key = {pmid29622083}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Yasmeen_2018, title = {Immediate effects of mobile phone radiations on heart rate variability in college going students}, author = {Juveriya Yasmeen and Mehnaaz Sameera Arifuddin and Nazeema Khatoon and Umaima Mahveen and Mohammed Abdul Hannan Hazari}, url = {https://njppp.com/?mno=273250}, doi = {10.5455/njppp.2018.8.0727708082017}, issn = {2320-4672}, year = {2018}, date = {2018-01-31}, urldate = {2017-01-31}, journal = {National Journal of Physiology, Pharmacy and Pharmacology}, volume = {8}, issue = {1}, pages = {56-61}, publisher = {ScopeMed}, abstract = {Background: The use of mobile phone has increased excessively these days which can have a deleterious effect on human tissues and organs, especially cardiovascular system (CVS). The effects on CVS can be detected at an early stage by analyzing alterations in heart rate variability (HRV). Aims and Objectives: This study was designed to determine the effect of mobile phone use with different components of HRV. Materials and Methods: In our study, HRV was measured in 95 college-going students (males: 49 and females: 46) using root mean square polyrite-D during 3 phases with each phase being recorded continuously for 2 min: Phase 1: Basal recording; Phase 2: Mobile phone use during active call with direct contact to the ear; and Phase 3: Mobile phone use during active call with earphones. Data obtained were subjected to statistical analysis using repeated measures non-parametric test followed by multiple comparison tests. Results: There was a significant increase in mean HR and decrease in mean RR interval from baseline through Phase 3 to Phase 2. This study shows that there was statistically significant change in root of the mean of the sum of the squares of differences, low frequency (LF), high frequency (HF), and LF/HF ratio between basal recording and during active call (direct contact of mobile phone to the ear and also with use of earphones); however, no change was seen between direct contact of mobile phone to the ear and during the use of earphones. Standard deviation of all normal-to-normal intervals did not show any significant change. We also observed gender differences in some of the HRV parameters. Conclusion: There is a considerable effect of mobile phone use on HR and HRV parameters. Furthermore, the changes noted are less with earphone use than when compared with the use of mobile phone in direct contact with the ear though these differences were not significant statistically.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2018e, title = {Bioengineered humanized livers as better three-dimensional drug testing model system}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Chandrakala Lakkireddy and Raju Nagarapu and Md. Aejaz Habeeb and Aleem Ahmed Khan}, url = {https://f6publishing.blob.core.windows.net/50475439-e1e8-4d32-b8ca-07dbaee5e315/WJH-10-22.pdf}, doi = {10.4254/wjh.v10.i1.22}, issn = {1948-5182}, year = {2018}, date = {2018-01-27}, urldate = {2018-01-01}, journal = {World Journal of Hepatology}, volume = {10}, issue = {1}, pages = {22-33}, publisher = {Baishideng Publishing Group Inc.}, abstract = {AIM: To develop appropriate humanized three-dimensional ex-vivo model system for drug testing. METHODS: Bioengineered humanized livers were developed in this study using human hepatic stem cells repopulation within the acellularized liver scaffolds which mimics with the natural organ anatomy and physiology. Six cytochrome P-450 probes were used to enable efficient identification of drug metabolism in bioengineered humanized livers. The drug metabolism study in bioengineered livers was evaluated to identify the absorption, distribution, metabolism, excretion and toxicity responses. RESULTS: The bioengineered humanized livers showed cellular and molecular characteristics of human livers. The bioengineered liver showed three-dimensional natural architecture with intact vasculature and extra-cellular matrix. Human hepatic cells were engrafted similar to the human liver. Drug metabolism studies provided a suitable platform alternative to available ex-vivo and in vivo models for identifying cellular and molecular dynamics of pharmacological drugs. CONCLUSION: The present study paves a way towards the development of suitable humanized preclinical model systems for pharmacological testing. This approach may reduce the cost and time duration of preclinical drug testing and further overcomes on the anatomical and physiological variations in xenogeneic systems.}, key = {pmid29399275}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Khan_2018, title = {Bacteriological profile and antibiogram of isolates from pus samples in a tertiary care center}, author = {Rozina Arshi Khan and Mahwish Jawaid and Mohammed Khaleel}, url = {https://www.ijcmas.com/7-1-2018/Rozina%20Arshi%20Khan,%20et%20al.pdf}, doi = {10.20546/ijcmas.2018.701.044}, isbn = {2319-7692}, year = {2018}, date = {2018-01-10}, urldate = {2018-01-10}, journal = {International Journal of Current Microbiology and Applied Sciences}, volume = {7}, issue = {1}, pages = {387-394}, abstract = {Pus is one of the major samples received in the Microbiology laboratory for culture and sensitivity. Though the bacterial profile from pus samples remain similar in various studies, the inadvertent use of antibiotics has lead to the emergence of various drug resistant pathogens, which in turn acts as a great challenge to the health services. A total number of 233 pus samples obtained for aerobic culture and sensitivity from different IPDs and OPDs of Owaisi Group of Hospitals associated with Deccan College of Medical Sciences, Hyderabad during a period from June 2017 to October 2017 were processed using standard microbiological processed and antibiotic susceptibility testing was done as per CLSI guidelines. Analysis of 233 pus samples showed 65.2% culture positivity (M:F=1.30:1.00) with Surgical wards (33.5%) being the major contributor. Klebsiella spp (36.2%) was the most common organism followed by Staphylococcus aureus (21.7%). Antibiotic sensitivity profile of Gram negative bacteria showed sensitivity towards imipenem (92.7%), piperacillin (89.1%) and amikacin (87.2%). Staphylococcus aureus was susceptible to Linezolid (100%), Vancomycin (100%). The prevalence of MRSA was 12.12%. A continuous inspection should be carried out to monitor the antimicrobial susceptibility of bacterial isolates from pus samples to chose appropriate antibiotics for prophylaxis and treatment of infections.}, keywords = {Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Sarvepalli_2018, title = {Study of therapeutic efficacy of febuxostat in chronic kidney disease stage IIIA to stage VD}, author = {Partha Saradhi Sarvepalli and Mehruq Fatima and Abdul Khalid Quadri and Aliya Raeesa Taher and Ayesha Habeeb and Fayeza Amreen and Badarunnisa Nikhat Parveen and K. G. Rajaram}, url = {https://journals.lww.com/sjkd/fulltext/2018/29050/study_of_therapeutic_efficacy_of_febuxostat_in.5.aspx}, doi = {10.4103/1319-2442.243953}, issn = {1319-2442}, year = {2018}, date = {2018-01-01}, urldate = {2018-01-01}, journal = {Saudi Journal of Kidney Diseases and Transplantation}, volume = {29}, issue = {5}, pages = {1050-1056}, publisher = {Medknow}, abstract = {Hyperuricemia [serum uric acid (SUA) >7.0 mg/dL] which is common in chronic renal diseases is associated with augmented vascular events. In addition to nonpharmacological therapy, hypouricosuric drugs reduce UA levels. The current study was a prospective observational study of six months duration November 2016 to April 2017 done to determine the efficacy of febuxostat in patients with hyperuricemia in chronic kidney disease (CKD) stage G3a to G5 and to correlate any association with reduction of hypertension, improvement in glomerular filtration rate (GFR), and reduction in comorbidities. The study was carried out at the Department of Nephrology, Owaisi Hospital and Research Center, Hyderabad. One hundred and ten patients were screened, of which 53 patients wherein stage G3a to G5 were recruited and SUA levels were obtained after inclusion criteria. SUA >6.0 in females and 7.0 in males were recruited. The drug febuxostat 40 mg was given once day to all patients with stage G3a to G5D with elevate uric acid levels >7.0 in males and more than 6.0 in females and three samples of UA were obtained monthly. The mean of GFR, blood pressure (BP), and SUA levels were obtained before and after the therapy. Of the 53 patients, males were 32 (60.3%), and females were 21 (39.6%). Mean age of the patients were 36.5 years. Mean UA levels before the start of febuxostat therapy were 8.6, and after adding febuxostat, it was 5.10 at the end of the third visit. The mean BP drop was 7.2 ± 2.1 mm in systolic BP (from 154–147 mm Hg) and diastolic BP drop was 93 ± 2.5 mm Hg (5.1 mm Hg). The mean GFR improved from 50.3 to 53.3 mL/min after the start of febuxostat. Febuxostat in asymptomatic CKD patients improves UA levels, BP and estimated GFR at low dose without any adverse events and no cardiac-related events.}, key = {pmid30381500}, keywords = {Nephrology}, pubstate = {published}, tppubtype = {article} } @article{Syed_2018, title = {Comparison of efficacy and pharmacoeconomics of two helicobacter pylori eradication regimens in peptic ulcer disease}, author = {Syeda Zaineb Kubra Hussaini and Syeda Zaineb Humaira Hussaini and Ruheena Yasmeen and Bader Unnisa and Aamir Ali Asgar Syed and Md. Nematullah Khan and Syed Ibrahim Hassan}, url = {https://journals.lww.com/picp/fulltext/2018/09010/comparison_of_efficacy_and_pharmacoeconomics_of.2.aspx}, doi = {10.4103/picr.picr_99_16}, issn = {2229-3485}, year = {2018}, date = {2018-01-01}, urldate = {2018-01-01}, journal = {Perspectives in Clinical Research}, volume = {9}, issue = {1}, pages = {4-8}, publisher = {Medknow}, abstract = {Background: Helicobacter pylori, the cause of most peptic ulcer diseases, infects approximately 50% of the population worldwide. Indian data on cost and effectiveness of the standard first-line therapies for H. pylori eradication are scarce. Thus, the present study was aimed at comparing the cost and efficacy of two standard first-line therapies: Regimen I comprising pantoprazole (40 mg) plus amoxicillin (750 mg) plus clarithromycin (500 mg) (PAC) and Regimen II comprising rabeprazole (20 mg) plus amoxicillin (625 mg) plus metronidazole (200 mg) (RAM). Methodology: This prospective, observational, bottom-up study collected demographic, economic, diagnostic, and therapeutic data from 60 H. pylori-positive patients. The study was carried out for 6 months in the Gastroenterology Department of a Tertiary Care Hospital in Hyderabad, Telangana, India. Results: Health-care system perspective was used to account for direct costs. Average cost per patient for complete H. pylori eradication was Rs. 10,221 and Rs. 8568 for Regimen I and Regimen II, respectively. Inpatient cost was considerably higher than the outpatient cost. Diagnostic costs ranked first in direct costs, followed by hospitalization costs, medication costs, and finally, physician's office visit cost. Individual patient's costs difference between two regimens was found to be statistically significant. Overall, Regimen I proved to be more efficacious than Regimen II, but Regimen II proved to be more cost-effective than Regimen I. Furthermore, incremental cost-effectiveness analysis revealed additional cost of Rs. 127 per patient if the patient was treated with Regimen I instead of Regimen II. Conclusion: Our study showed that Regimen II (RAM) was more cost-effective than Regimen I (PAC), but PAC achieved faster H. pylori eradication than RAM. We assume that this study provides local clinical data as to which regimen may be useful in a particular patient. National Level Clinical Trials are required to further ascertain this conclusion.}, key = {pmid29430411}, keywords = {Deccan School of Pharmacy, Medical Gastroenterology}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2018, title = {Cutaneous changes in neonates in the first 72 hours of birth: an observational study}, author = {Harshita B. Reddy and Nayantara R. Gandra and Tina P. Katta}, url = {https://www.eurekaselect.com/article/81815}, doi = {10.2174/1573396313666170216120230}, issn = {1573-3963 }, year = {2018}, date = {2018-01-01}, urldate = {2018-01-01}, journal = {Current Pediatric Reviews}, volume = {13}, issue = {2}, pages = {136-143}, publisher = {Bentham Science Publishers Ltd.}, abstract = {Background: Variation in neonatal skin changes and clinical presentation is a frequent occurrence. We studied the pattern of cutaneous manifestations in new-borns <72 hours of birth. Method: We included all live babies delivered in our hospital; Babies were categorised according to age, birth weight and gestational age. Neonates were examined within 24 hours of birth and daily for skin lesions for 72 hours. Skin lesions were categorised into physiological, transient eruptions, due to infections, congenital anomalies and miscellaneous. Results: Of 200 new-borns, 108 (54%) were females; 180 (90%) full term babies (37-41 weeks). Non-consanguinity was noted in parents of 175 (87.5%) babies. One hundred and thirty one (65%) babies were delivered normally by vaginal route, and 69 (34.5%) by Caesarean section. 176 (88.0%) were average birth weight babies. Mean±SD lesion burden/neonate was 3.925±1.2 (n=785 lesions, 1-8 lesions/neonate). Transient skin lesions were frequent (n=451 in 198 patients, Mean±SD 2.30±0.76) followed by physiological conditions (n=284, Mean±SD 1.44±0.82). Infectious, developmental, iatrogenic and miscellaneous lesions were less frequent (mean±SD lesions 0.015±0.12, 0.0115±0.32, 0.015±0.12, and 0.035±0.18, respectively). Statistically significant (p<0.001) relationship was noted between gestational age and number of lesions; more number of full term babies had lesions, while number of lesions (>6) were more in preterm babies. All lesions occurred within 24 hours of birth except erythema toxicum neonatorum (n=124) wherein 80 were seen on day 1, and 43 on day 2. Conclusion: We confirm the variation in cutaneous lesions and their time of onset in neonates. Transient and physiological changes are more frequent and disappeared spontaneously. Number of lesions/neonate was more in premature babies.}, key = {pmid28215177}, keywords = {Dermatology, No Department}, pubstate = {published}, tppubtype = {article} } @article{Rabbani_2018, title = {A cross sectional study on menstrual pattern and hygienic practices amongst school going adolescent girls in urban health centre practice area}, author = {Hajera Rabbani and M. S. K. Swarupa and Mohammed Sarosh Ahmed and A. Chandrasekhar}, url = {https://ijphrd.com/scripts/IJPHRD%20Jan%202018.pdf}, doi = {10.5958/0976-5506.2018.00020.7 }, issn = {0976-0245}, year = {2018}, date = {2018-01-01}, urldate = {2018-01-01}, journal = {Indian Journal of Public Health Research and Development}, volume = {9}, issue = {1}, pages = {104-107}, abstract = {Introduction: Myths and misconceptions related to menstruation are often associated with some degree of sufferings and embarrassment among adolescent girls. The present study was planned to find out the menstrual pattern among girls as well as their menstrual hygienic practices. Methods: Cross sectional study done in private schools during July 2015 to Sept 2015. Results: The mean age of menarche of the study participants was found to be 13 years 9 months. Around 17.3% girls had irregular menstrual cycles, 40.7% girls were suffering from dysmenorrhea and 34.7% were having backaches. Knowledge regarding menstruation was adequate in 37.3% girls, about 73.3% avoids social gathering and 54.3% were irregular to school during menstruation. About 16.7% of the students were not using sanitary pads. About 26 % girls were having good personal hygiene and 54.6% of participants felt shy watching advertisements regarding sanitary napkins in front of male members. Conclusion: Our study concludes that the prevalence of menstrual irregularity, dysmenorrhoea led to absenteeism which affect the academics and quality of life of students. Awareness regarding menstrual hygiene was also found to be low. Low level of social participation was also seen during menstruation. Awareness programs involving school teachers is the need of the hour. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @book{Ahmed_2018c, title = {Forensic Medicine and Toxicology (Theory/Practical and Viva)}, author = {Khazi Mudabbir Ahmed}, isbn = {978-93-86480-17-0}, year = {2018}, date = {2018-01-01}, urldate = {2018-01-01}, booktitle = {Forensic Medicine and Toxicology}, publisher = {Paras Medical Books Pvt. Ltd.}, address = {Hyderabad}, edition = {1st}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {book} } @article{Ravi_2017, title = {Gossypiboma: an enigma}, author = {Ganji Ravi and Nikhilesh Vedire and Mohammed Abdul Hadi and Syed Nusrath Farees and Venkat Naveen Reddy M.}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=December_2017_1512223653__266.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2017}, date = {2017-12-31}, urldate = {2017-12-31}, journal = {International Journal of Scientific Research}, volume = {6}, issue = {12}, pages = {381-384}, abstract = {Retained surgical sponge in the body following surgery though not as common in the present times as in the pre laparoscopic era, when laparotomies were routinely done for abdominal pathology is still a much feared entity mainly from the surgeons point of view as it is a sure shot way to infamy legal tangles and financial troubles if discovered in unfavourable circumstances. What we have endeavoured to find out in our study of five gossypiboma cases which we have encountered in past 12 years and review of past cases published on this subject is – does the operating surgeon has any control over the unfolding events post inadvertent retention of the foreign body. DISCOVERIES One patient had a gauge piece tucked away behind the strap muscles, two patients were found with intraluminal migration of surgical sponge - one complete (tightly coiled). One incomplete (into jejunum and ileum). Two were discovered with sponge encapsulated between dense intestinal and bladder adhesion, one in the process of dissolution and another completely dissolved into abscess cavity without any bowel injury. CONCLUSION Heed patients complaints and have a high degree of suspicion when dealing with post op patients even when they complain of vague symptoms. These and quite a little bit of luck is required in surgical practise to help the surgeon stay clear of dangerous situations. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ramadugu_2017, title = {Intervention for phantom limb pain a randomized single crossover study of mirror therapy}, author = {Shashikumar Ramadugu and Satish C. Nagabushnam and Nagendra Katuwal and Kaushik Chatterjee}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806325/}, doi = {10.4103/psychiatry.IndianJPsychiatry_259_16}, issn = {0019-5545}, year = {2017}, date = {2017-12-31}, urldate = {2017-12-31}, journal = {Indian Journal of Psychiatry}, volume = {59}, number = {pmid29497188}, issue = {4}, pages = {457-464}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2017b, title = {"Neo-PIRO": introducing a novel grading system for surgical infections of neonates}, author = {G. Raghavendra Prasad and J. V. Subba Rao and Amtul Aziz and T. M. Rashmi}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615894/?report=reader}, doi = {10.4103/0971-9261.214455}, issn = {0971-9261}, year = {2017}, date = {2017-12-31}, urldate = {2017-12-31}, journal = {Journal of Indian Association of Pediatric Surgeons}, volume = {22}, issue = {4}, pages = {211-216}, abstract = {Introduction: Quantification of surgical sepsis was never done beyond superficial, subfascial, and deep surgical site infection (SSI). Invasive surgical sepsis with systemic manifestation has not been tried to be quantified in general and pediatric surgery in particular. Hence, this attempts to develop a novel grading system to quantify neonatal surgical infections. Materials and Methods Predisposing factors, infection, response, and organ failure (PIRO) is being used in critical care institutions for medical sepsis; it was modified with neonate-specific surgical parameters. Authors have developed a grading of these parameters into Grade I, II, and III. Results: A blinded statistical test was performed and results were put to test. Extended Mantel–Haenszel Chi-square test validated linear relationship with grade and outcome, hospital stay, deep SSI, and organ dysfunction. Analysis of variance also showed the significant relationship of changing trends in grade and outcome. (1) Higher the grade indicated the probability of death. (2) Grade I patients had less duration of hospital stay compared to Grade II and III (P = 0.04). (3) The requirement of organ support and SSI were also more in Grade III. (4) Grade I patients had less increase in trends compared to Grade II and III (F = 4.86). Authors therefore feel Neo-PIRO seems to be the first scoring system that shows a linear relationship between scores and grade. Conclusion: Neo-PIRO is a novel grading system with surgical neonate-specific parameters. Future versions to include molecular parameters, as well as parameters selected by regression analysis.}, keywords = {Anesthesiology, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2017, title = {Non-randomised control trial of glycolic acid 12% cream versus azelaic acid 10% cream in melasma}, author = {Fatima Razvi and Nayeem Sadath Haneef and Polishetty Sravanthi and Fatima Ummul Hasnath and Ramesh Bang}, url = {https://www.jemds.com/data_pdf/Nayeem,%20Dec%2018,.pdf}, doi = {10.14260/jemds/2017/1493}, issn = {2278-4748}, year = {2017}, date = {2017-12-18}, urldate = {2017-12-18}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {6}, issue = {94}, pages = {6891-6894}, abstract = {BACKGROUND: Melasma is most common acquired hypermelanosis which presents with asymmetrical hyperpigmentation usually involving the malar, mandibular or centrofacial area. It is seen in South East Asia especially in skin photo types 3 & 4. It is seen mainly in women during childbearing age and its onset may correlate with pregnancy or the use of oral contraceptive pills. The other commonly known factors in its pathogenesis include genetic influences, endocrine factors, use of cosmetics, certain drugs like anticonvulsants, steroids and exposure to sunlight (UVA, UVB and visible light). Hydroquinone is being used for treatment of melasma since long time as it is efficacious, but it has adverse effects like contact dermatitis, exogenous ochronosis. Hence, we tried non-hydroquinone based topical medications which are safe, efficacious and are known to target melanocytes and various steps of melanogenesis. The aim of this study is to compare the efficacy of topical Glycolic acid 12% cream versus Azelaic acid 10% cream in melasma. MATERIALS AND METHODS: Settings and Design- Prospective non-randomised controlled trial of efficacy and safety of Glycolic acid 12% cream versus Azelaic acid 10% cream. 100 patients of melasma who completed all followups were included in this study for a period of 12 weeks and randomly assigned to one of the following groups: Group A - 12% Glycolic acid cream. Group B - 10% Azelaic acid cream. Statistical Analysis- Every 2 weeks and at the end of 12 weeks, the two treatment groups were compared for efficacy and adverse effects and the results were analysed with Chi-square test. Yates correction was applied wherever necessary. RESULTS: The response to Azelaic acid 10% cream was relatively higher than Glycolic acid 12% cream. Cut-offs were considered and these differences were statistically significant (0.001 and 0.012). It was observed that higher proportion of patients with Glycolic acid 12% cream had adverse effects when compared to Azelaic acid 10% cream except for dryness. CONCLUSION: When the two topical medications were compared we found that Azelaic acid 10% cream was more tolerable and efficacious with maximum resolution than Glycolic acid 12% cream.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2017, title = {Glycemic impact of individual oral hypoglycemic drugs in type 2 diabetes mellitus-an observational study}, author = {Anjum Sultana Khatoon and Mohammed Mansoor Ali Khan Lodhi}, url = {https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_1762_v1.pdf}, issn = {2393-915X}, year = {2017}, date = {2017-12-08}, urldate = {2017-12-08}, journal = {International Journal of Contemporary Medical Research}, volume = {4}, issue = {11}, pages = {2454-2459}, abstract = {Introduction: The Incidence and prevalence of type 2 diabetes mellitus around the world is dramatically increasing over the past decades. Study aimed to assess the effectiveness of various Oral Hypoglycemic drugs on glycemic levels in established Type 2 Diabetes Mellitus patients. Material and Methods: In the present study 300 diabetic patients were selected and randomized into three groups. Group A comprised 100 patients whose baseline glycemic parameters were recorded and patients received Vildagliptin 50 mg twice a day, whereas Group B comprised of 100 patients and these patients received metformin 0.5gm–2gm/day and Group C comprised of 100 patients and these patients received Voglibose 0.2mg thrice a day for 24 weeks. Patients were monitored closely for ensuring the compliance to diet, drug and exercise. Result: In the present study patients were randomly divided into three groups, Group A on Vildagliptin 50 mg, Group B on metformin 500mg – 2000mg. Group C on Voglibose 0.2mg. These entire three groups baseline FBS, PLBS, HBa1C was estimated prior to the study. It was observed that the mean baseline HBA1c in the Group A patients was 7.83 % and in Group B was 7.92%, Group C was 7.94% whereas the mean HbA1c after 24 weeks of therapy was 7.42%, 7.78% and 7.81% respectively in the Group A, B, and C. There was a significant decrease in HBA1c in all these three groups and it was statically significant. Conclusion: In summary, all three Oral hypoglycemic agent vildagliptin or metformin or voglibose monotherapy helped in improving glycemic control in patients with type 2 diabetes mellitus. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Supriya_2017, title = {Dowling Degos disease: a clinicopathological study}, author = {M. Supriya and Syeda Naushaba Masood and Atiya Begum}, url = {https://www.rfppl.co.in/view_abstract.php?jid=10&art_id=6328}, doi = {10.21088/ijprp.2278.148X.6417.48}, issn = {2278-148X}, year = {2017}, date = {2017-12-01}, urldate = {2017-12-01}, journal = {Indian Journal of Pathology: Research and Practice}, volume = {6}, number = {2}, issue = {4}, pages = {1114-1118}, abstract = {Background: DowlingDegos Disease (DDD) is a rare genetic disease of the skin having an autosomal dominant inheritance. It is grouped under reticulated pigmented anomalies and manifests as symmetric, progressive, pigmented macules over flexures, scattered comedolike lesions and pitted acneiform scars. Histopathology is required for definitive diagnosis and to distinguish it from other reticulate pigmentary genodermatoses. Aims: 1. To show the existence of this rare disease in the local population. (2) To stress on the clinicopathological correlation for the definitive diagnosis of the disease. Materials & Methods: Punch biopsies of skin received by the Department of Pathology over a span of two years with Dowling Degos Disease as one of the differential diagnosis, were included in the study. The biopsies were processed as per standard protocol. Diagnosis was confirmed by the histopathological examination. Result: A total of six cases were included in the study, out of which four were histologically confirmed as DDD and one case had features overlapping with Reticulate Acropigmentation of Kitamura (RAPK). The study showed female preponderance. Four cases had family history. The clinical and histopathological findings of each case are discussed. Conclusion: Dowling Degos Disease may not be a rare entity. It should be considered as one of the differential diagnoses for pigmentary disorders. With combined clinical and histopathological evaluation, more cases may come into light in the future and DDD may not remain as a rare disorder.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2017, title = {Organophosphorous poisoning cases in different persons in different circumstances}, author = {Abdul Rahman Omer Siddiqui and Iqbal Banu Hussain}, url = {https://www.ijfmt.com/scripts/IJFMT%20July-Dec%202017%20(147%20articles).pdf}, doi = {10.5958/0973-9130.2017.00055.X}, issn = {0973-9122}, year = {2017}, date = {2017-12-01}, urldate = {2017-12-01}, journal = {Indian Journal of Forensic Medicine & Toxicology}, volume = {11}, issue = {2}, pages = {13-16}, abstract = {Organo-phosphorus insecticides are one of the most predominant insecticides used today and is a major clinical and public health problem across much of rural Asia for self poisoning. In the present study the circumstances leading to poisoning and the survival period of the victims have been discussed. It is observed from the present study that more cases are seen on Monday and Thursday followed by the weekend days Friday, Saturday and Sunday and least is seen on Tuesday and Wednesday. Home is the ideal place to consume poison preferred by many victims.}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Kumar_2017, title = {Clincial relevance of MMP-9 in terms of neoplasm growth, invasion and metastasis in thyroid, breast and colorectal cancer}, author = {V. Hari Kumar and Omar Bin Hasan }, url = {https://www.ijsurgery.com/index.php/isj/article/view/2076/1665}, doi = {10.18203/2349-2902.isj20175408 }, issn = {2349-2902}, year = {2017}, date = {2017-11-25}, urldate = {2017-11-25}, journal = {International Surgery Journal}, volume = {4}, issue = {12}, pages = {4049-4053}, abstract = {Background: Cancer cells invade and metastasis commonly. This poses challenge in cancer management. MMP-9 can be clinically useful to predict the prognosis of the patients. Objective was to study clinical relevance of MMP-9 in terms of neoplasm growth, invasion and metastasis in Thyroid, Breast and Colorectal cancer. Methods: A hospital based cross sectional study was carried out in Department of General Surgery, Kamineni Institute of Medical Sciences, Narketpally for a period of two years. A total of 30 cases of carcinoma cases were studied. Out of these carcinoma cases, 10 were of gastrointestinal malignancy, 10 were of thyroid malignancy and 10 were of breast carcinoma. Results: For breast carcinoma, maximum cases were in the age group of 46-50 years (40%), for thyroid carcinoma, maximum cases were seen in the age group of more than 55 years (40%), for colo-rectal carcinoma, maximum cases were above the 50 years of age. For breast carcinoma, maximum cases were in stage III B (70%), for thyroid carcinoma, in III stage (60%) and for colo-rectal carcinoma, in Dukes C1 stage (60%). In breast cancer the positivity of MMP-9 was 66.7% in stage IIIA and it increased to 85.7% in stage IIIB. For thyroid cancer the positivity increased from 33.3% in stage III to 75% for stage IV A. In case of colo-rectal cancer, the positivity of MMP-9 expression increased from 66.7% for stage Dukes C 1 to 75% in stage Dukes C2 stage. Thus, for all types of carcinoma, the expression of MMP-9 increased with advancement of the stage. Conclusions: MMP-9 is a gelatinase which degrades extra cellular matrix and helps in tumor spread. It is expressed more in advanced stages of the malignant disease. It correlates with prognosis of the patient.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2017b, title = {The association of hyperuricemia with progressive diabetic nephropathy in patients with type II diabetes mellitus}, author = {Suhail Bin Ahmed and Ather Akhtar Pasha and Yogita Singh Thakur}, url = {https://www.iaimjournal.com/storage/2017/11/iaim_2017_0411_37.pdf}, issn = {2394-0026}, year = {2017}, date = {2017-11-04}, urldate = {2017-11-04}, journal = {International Archives of Integrated Medicine}, volume = {4}, issue = {11}, pages = {269-274}, abstract = {Background: Diabetic nephropathy (DN) is a progressive kidney disease caused by the damage to the capillaries in the kidneys’ glomeruli. Uric acid is the end product of purine catabolism and is excreted in the urine. Uric acid can serve as an inflammatory factor and is attributed to bring about endothelial dysfunction. The causal role of uric acid in the development of diabetic nephropathy is unknown. This study aimed to evaluate the association of serum uric acid level and low levels of estimated glomerular filtration rate (eGFR) which is an indicator of renal disease progression in patients with Type II (T2D) diabetes mellitus. Methods: A cross sectional analytical observational study was conducted on 150 patients with T2D. Since the study was an observational study it involved no medical intervention. Venous blood samples were obtained in fasting state for determination of random blood sugar, serum creatinine, uric acid, (HbA1c) hemoglobin A1c (reference range 3.8-5.5%); and blood urea nitrogen (BUN). Using MDRD formula eGFR was calculated as = 186 x [serum creatinine]-1.154 x [Age] -0.203 x 0.742. The association of renal disease with T2D and the grading of the patients into different stages of renal failure was analysed by eGFR values. Results: Hundred and fifty diagnosed cases of T2D were included in the present study. The mean age of the study population was 63 ± 12.2. No significant age and gender related variation in serum uric acid level was noted in the study population. The prevalence of Hyperuricemia was 19.33%. The mean BMI was significantly higher among hyperuricemic subjects in comparison with normouricemic patients. Hyperuricemia was evident in 75% (n=18) of the subjects with diabetic nephropathy. Stage IV and stage V patients were associated with significantly very high (p < 0.01) uric acid levels. Conclusions: Serum uric acid has a significant positive association with diabetic nephropathy ultimately resulting in end stage renal disease. Treatment intervention is out of the scope of this study.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2017c, title = { Incidence of sub clinical thyroid dysfunction among asymptomatic adult population}, author = {Suhail Bin Ahmed and Ather Akhtar Pasha and Yogita Singh Thakur}, url = {https://www.iaimjournal.com/storage/2017/11/iaim_2017_0411_36.pdf}, issn = {2394-0026}, year = {2017}, date = {2017-11-04}, urldate = {2017-11-04}, journal = {International Archives of Integrated Medicine}, volume = {4}, issue = {11}, pages = {264-268}, abstract = {Background: Patients with subclinical thyroid dysfunction are universally encountered in routine clinical practice. Advanced diagnostic techniques have created new categories of thyroid disorders such as subclinical hypo-and-hyperthyroidism. The management of subclinical thyroid dysfunction is controversial. Patients with subclinical thyroid dysfunction may have vague, nonspecific symptoms that do not aid the clinical apperception. This study aimed to screen the normal adult population for the incidence of subclinical thyroid dysfunction and discuss the optimal management strategy. Materials and methods: Four hundred subjects with no clinical evidence of thyroid dysfunction were included in the present study. Elaborate history in the form of a symptom questionnaire was obtained and clinical examination was performed. Laboratory analysis of thyroid function was done by electro-chemiluminescence immunoassay (ECLIA). Patients with normal free thyroxine (FT4) and tri-iodothyronine levels (T3) were further classified into subclinical hypo/hyperthyroid based on the serum thyroid-stimulating hormone (TSH) levels. The incidence of subclinical thyroid disorder in the sample population was detected and optimal management strategies were followed as per the European thyroid association (ETA) guidelines. Results: The normal TSH value by ECLIA was 0.27 - 4.2μIU/ml. Seventeen (4.25%) out of four hundred subjects included in the present study were found to have subclinical thyroid dysfunction. The Ratio of subclinical hypothyroid cases to subclinical hyperthyroid cases was found to be 12:5. Clustering of the cases was found around the age of 60 years and was significantly more common among females in comparison to males. Cases with subclinical thyroid dysfunction were managed by follow up after a thorough evaluation and treatment of other comorbid conditions. Conclusions: The study provides valuable insight towards understanding the epidemiology and management of subclinical thyroid disorders in the present scenario. Screening is recommended for a high-risk population since there is good evidence that subclinical thyroid dysfunctions may be associated with progression to overt disease in up to 5% of the population.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Nizamuddin_2017, title = {Implementing protocols to improve patient safety in the medical imaging department with emphysis on use of gadolinium for renal failure}, author = {Mohammed Nizamuddin and Syed Althaf Ali}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=November_2017_1509531046__90.pdf}, doi = {10.36106/ijsr}, issn = {2277-8179}, year = {2017}, date = {2017-11-01}, urldate = {2017-11-01}, journal = {International Journal of Scientific Research}, volume = {6}, issue = {11}, pages = {239-242}, abstract = {Patient safety is a focal point in healthcare because of recent changes issued by CMS. Hospital reimbursement rates have fallen, and these reimbursement rates are governed by CMS mandates regarding patient safety procedures. Reimbursement changes are reflected in the National Patient Safety Goals (NPSGs) administered annually by The Joint Commission. Medical imaging departments have multiple areas of patient safety concerns including effective handoff communication, proper patient identification, and safe medication/contrast administration. This literature review examines those areas of patient safety within the medical imaging department and reveals the need for continued protocol and policy changes to keep patients safe. The purpose of this study was to determine the incidence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) and moderate-to-severe impairment of kidney function who had not previously been exposed to gadolinium-based contrast agents (GBCAs) or referred to undergo contrast-enhanced MRI with gadobenate dimeglumine or gadoteridol.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2017c, title = {Protective role of hypothermia against heat stress in differentiated and undifferentiated human neural precursor cells: a differential approach for the treatment of traumatic brain injury}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Nusrath Fathima and Chandrakala Lakkireddy and Syed Rahamathulla and Nagarapu Raju and Gunda Srinivas and Avinash Raj and Sandhya Annamaneni and Vishnupriya Satti and Santosh Kumar Tiwari and Syed Ameer Basha Paspala and Aleem Ahmed Khan}, url = {https://bcn.iums.ac.ir/article-1-647-en.pdf}, doi = {10.29252/nirp.bcn.8.6.453}, issn = {2008-126X}, year = {2017}, date = {2017-11-01}, urldate = {2017-11-01}, journal = {Basic and Clinical Neuroscience Journal}, volume = {8}, issue = {6}, pages = {453-466}, publisher = {Negah Scientific Publisher}, abstract = {Introduction: The present study aimed to explore protective mechanisms of hypothermia against mild cold and heat stress on highly proliferative homogeneous human Neural Precursor Cells (NPCs) derived from Subventricular Zone (SVZ) of human fetal brain. Methods: CD133+ve enriched undifferentiated and differentiated human NPCs were exposed to heat stress at 42°C. Then, Western-blot quantification was performed using Hsp-70 (70 kilodalton heat shock proteins) recombinant protein. Finally, changes in pluripotency and Hsp-70 expression were measured using immunofluorescence staining and RT-qPCR (Quantitative reverse transcription PCR) analysis, respectively. Results: Heat stress resulted in abnormal neurospheres development. The apoptosis rate was enhanced during long-term in vitro culture of neurospheres. Neurogenic differentiation reduced and showed aberrent phenotypes during heat stress. After hypothermia treatment significant improvement in neurospheres and neuronal cell morphology was observed. Conclusion: Mild-hypothermia treatment induces attenuated heat shock response against heat stress resulting in induced HSP-70 expression that significantly improves structure and function of both undifferentiated human NPCs and differentiated neurons.}, key = {pmid29942429}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2017, title = {Altered activity of lecithin cholesterol acyl transferase enzyme and high density lipoprotein in type 2 diabetes mellitus}, author = {Tahmeen Jameel and Raisa Faheem and Aiman Mahmood and Afnan Ali Afrooz}, url = {https://www.medpulse.in/Biochemistry/Article/Volume4Issue2/Biochem_4_2_1.pdf}, doi = {10.26611/1002421}, issn = {2550-763X}, year = {2017}, date = {2017-10-26}, urldate = {2017-10-26}, journal = {MedPulse International Journal of Biochemistry}, volume = {4}, issue = {2}, pages = {29-31}, abstract = {An important enzyme in modulating plasma HDL levels is cholesterol acyl transferase (LCAT) which is responsible for the formation of most of the cholesterol esters (CE) present in human plasma. This enzyme catalyses the transfer of fatty acid from the Sn-2 position of the lecithin to the free hydroxyl group of cholesterol. It utilizes linoleate for the esterification of cholesterol in preference to the other fatty acids. Thus the enrichment of the linoleate content of plasma lecithin which accompanies ingestion of a poly unsaturated fat diet leads to an increase in the proportion of cholesterol linoleate in plasma. The physiological substrate for LCAT is probably nascent HDL. The enzyme activity is dependent on apoA-1 and in inhibited by apoA-2. Thus the maturing HDL particles contain mainly esterified cholesterol which having been rendered non diffusible are trapped in the HDL and then are transferred to the liver to undergo catabolism. Present studies have been carried out on diabetic patients with good glycaemic control and diabetics with poor glycaemic control and compared with normal control group. HDL cholesterol levels in diabetic patients with good and poor glycaemic control were significantly lower than the normal control group. LCAT in diabetic patients with good and poor glycaemic control were significantly lower than the normal control group. However HDL cholesterol level and LCAT activity in diabetic patients with poor glycaemic control was still lower this supports the observation that coronary artery disease (CAD) is 2-4 times higher in diabetes than non diabetes.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2017, title = {Study of plasma fibrinogen in diabetes mellitus with complications}, author = {Tahmeen Jameel and Raisa Faheem and Syyeda Anees}, url = {https://www.medpulse.in/Biochemistry/Article/Volume4Issue1/Biochem_4_1_2.pdf}, doi = {10.26611/1002412}, issn = {2550-763X}, year = {2017}, date = {2017-10-23}, journal = {MedPulse International Journal of Biochemistry}, volume = {4}, issue = {1}, pages = {5-7}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Ahmedi_2017, title = { Prospective study on prescribing pattern in type 2 diabetes mellitus patients in a tertiary care hospital}, author = {Urooj Ahmedi and Shaheda Siddiqui and Shafia Baseera and Pramod Kumar Korani Ratnam}, url = {https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_4_november_issue_11/1509439646.pdf}, issn = {2349-8870}, year = {2017}, date = {2017-10-18}, urldate = {2017-10-18}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {4}, issue = {11}, pages = {398-405}, abstract = {The study involves screening the prescription trends in type 2 diabetes mellitus patients with comorbid complications imposed with diabetes. However study was undertaken in the Owaisi Hospital and Research Center, to evaluate prevalence rate of type II diabetes mellitus in males and females & actual appropriateness which deserve clinical attention and choice of prescribing pattern promoting rational use of medications. The study was Simple Prospective observational study which was carried out for a period of two months.150 cases were collected in the study which determines number of OADDS therapy administered for type II DM patients ruling out generic or essential drug prescribing and also patients were counselled regarding the medications and diet to be followed to manage DM. The results were analysed. Maximum number of patients were in the age group of above 60 years (40.66%) and among 150 cases, males constituted 61 (40.66%) and females 89 (59.33%). Out of 150 patients 137 patients (91.33%) patients were found suffering with co morbid concurrent illness hypertension followed by other complications associated like CAD, CKD, Hypothyroid, Asthma, Rheumatoid Arthritis and other comorbidities. Essentially assessment of therapy and management of disease with combination therapies of insulin and different oral anti-diabetic drugs were prescribed for proper glycemic control. As well clinical attention on patient counselling by clinical pharmacist indicates clinical effectiveness of therapy influenced by prescribed agent selection and therapy changes as well patient’s adherence with drug regimens.}, keywords = {Deccan School of Pharmacy, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Kondeti_2017, title = {Effects of gestational diabetes in pregnancy}, author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam}, url = {https://www.medpulse.in/Article/Volume4Issue10/MedPulse_4_10_4.pdf}, doi = {10.26611/10041014}, issn = {2348-1897}, year = {2017}, date = {2017-10-16}, urldate = {2017-10-16}, journal = {MedPulse-International Medical Journal}, volume = {4}, issue = {10}, pages = {974-975}, abstract = {Gestational Diabetes Mellitus (GDM) is the most common medical complication and metabolic disorder of pregnancy. Proper recognition and intervention can reduce the well described GDM associated perinatal morbidity and mortality}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Moghadam_2017, title = {Pattern of dynamic intestinal obstruction in adults}, author = {Abdul Ghader Barazaneh Moghadam and Syed Asif Shah Harooni}, url = {https://www.iaimjournal.com/storage/2017/10/iaim_2017_0410_35.pdf}, issn = {2394-0026}, year = {2017}, date = {2017-10-11}, urldate = {2017-10-11}, journal = {International Archives of Integrated Medicine}, volume = {4}, issue = {10}, pages = {230-235}, abstract = {Background: In aboral direction, when the intestinal contents cannot be forced further, a situation arises known as intestinal obstruction. Aim: Aim was to evaluate the common causes of intestinal obstruction. Methods and materials: This study was a retrospective study which was conducted from January 2015 to April 2017 in Department of Surgery in Deccan College of Medical Sciences Hyderabad. This study consisted of 60 patients who were admitted in department of surgery who were presented with acute intestinal obstruction and patients who underwent operative management were included in the study. The patients who conservatively managed the obstruction and who were below 12 years of age were excluded from the study. Results: 60 patients underwent management operatively during the two years duration with the paediatric group excluding from the study (age below 12 years) and others got treatment conservatively. Males were more compared to female patients who constituted 39 (65%) males and 21 (35%) females. The most common occurrence of intestinal obstruction was in the age group of 42-51 years (33.3%). The most common presenting complaint is abdominal pain. The most common type of bowel obstruction is small intestine. Adhesion and band is the most common cause of intestinal obstruction 25 (41.6%), followed by Malignancy 15 (25%), obstructed hernia 5(8.3%), Volvulus 5 (8.3%), Stricture 4 (6.6%), Ileac tuberculosis 2 (3.3%), SMA thrombosis 2 (3.3%), superior mesenteric artery thrombosis 2 (3.3%). The most common type of surgery was adhesiolysis which constituted 20 (33.3%) followed by Resection and ostomy which constituted 10 (16.6%). The most common post-operative complication was wound infection which constituted 18 (30%). Conclusion: The most common cause of bowel obstruction is adhesive intestinal obstruction followed by malignant bowel obstruction. Early diagnosis, perioperative management and general condition of patients are keys in the successful management of acute intestinal obstruction.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kondeti_2017b, title = {Prevalence of thyroid disorder in pregnancy and pregnancy outcome}, author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam}, url = {https://www.medpulse.in/Article/Volume4Issue10/MedPulse_4_10_2.pdf}, doi = {10.26611/10041012}, issn = {2348-1897}, year = {2017}, date = {2017-10-07}, urldate = {2017-10-07}, journal = {MedPulse-International Medical Journal}, volume = {4}, issue = {10}, pages = {969-970}, abstract = {Thyroid disorders constitute one of the most common endocrine disorders seen in pregnancy. Maternal thyroid function changes during pregnancy and inadequate adaptation to these changes results in thyroid dysfunction. Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Kondeti_2017c, title = {Effect of maternal anemia on placental and fetal outcome}, author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam}, url = {https://medpulse.in/Article/Volume4Issue10/MedPulse_4_10_1.pdf}, doi = {10.26611/10041011}, issn = {2348-1897}, year = {2017}, date = {2017-10-02}, urldate = {2017-10-02}, journal = {MedPulse-International Medical Journal}, volume = {4}, issue = {10}, pages = {965-968}, abstract = {Anemia during pregnancy is very common. More than one-quarter of the world's population is anemic. Growth of the fetus is intricately linked with that of placenta, because placenta helps in transfer of nutrients and oxygen from mother to fetus. Placenta is a focus of increasing interest because significant pathology afflicts the placenta, often before affecting the fetus.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Shah_2017, title = {Bioresorbable vascular scaffold versus metallic stent in percutaneous coronary intervention: results of the AIDA trial}, author = {Syed Raza Shah and Mazia Fatima and Amin Muhammad Dharani and Waqas Shahnawaz and Syed Arbab Shah}, url = {https://www.tandfonline.com/doi/epdf/10.1080/20009666.2017.1374111?needAccess=true}, doi = {10.1080/20009666.2017.1374111}, issn = {2000-9666}, year = {2017}, date = {2017-10-01}, urldate = {2017-10-01}, journal = {Journal of Community Hospital Internal Medicine Perspectives}, volume = {7}, issue = {5}, pages = {307-308}, abstract = {Drug-eluting stents have significantly improved the long-term outcomes of percutaneous coronary intervention (PCI) by decreasing the excessive growth of neointima. However, conventional stents have some limitations. PCI with a bioresorbable vascular scaffold (BVS) has emerged as an alternative since the presence of the prosthesis in the coronary artery is transient. A US Food and Drug Administration advisory panel of experts recommended approval of BVS based on the analysis of its risks and rewards in July 2016. In June 2017, the preliminary results of the Amsterdam Investigator-initiateD Absorb Strategy All-comers (AIDA) trial were released. This randomized controlled trial compared an everolimus-eluting BVS with an everolimus-eluting metallic stent in the context of routine clinical practice. The preliminary results revealed no significant difference in target-vessel failure when BVS was compared with metallic stenting. However, during the 2 years of follow-up, BVS was associated with a higher rate of device thrombosis. This is seen as an important development in the trial. There are some concerns regarding stent thrombosis and the restoration of real vessel functionality in the long term. For these reasons, for now, metallic stents remain the treatment of choice for PCI.}, key = {pmid29147473}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Venkateshwarlu_2017, title = {Endovascular management of iatrogenic renal vascular injuries complicating percutaneous nephrolithotomy: role of renal angiography and embolization; an analysis of 159 cases}, author = {Jampala Venkateshwarlu and Sravan Kumar Marupaka and Ravindra Prakash Babu and Anand Abkari}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644321/pdf/IJRI-27-293.pdf}, doi = {10.4103/ijri.IJRI_54_17}, issn = {0971-3026}, year = {2017}, date = {2017-09-30}, urldate = {2017-09-30}, journal = {Indian Journal of Radiology and Imaging}, volume = {27}, issue = {3}, pages = {293-297}, abstract = {Objective: To describe the use of renal angiography in the detection of renal vascular injuries following percutaneous nephrolithotomy and to assess the efficacy of endovascular management of these complications. Materials and Methods: This was a retrospective review of 159 consecutive patients over a period of 12 years from 2005 to 2016 who presented with significant post nephrolithotomy hemorrhage and who were evaluated by renal angiography as a first‑line diagnostic study, followed by embolization of identified renal vascular injuries in the same session. The parameters assessed for each patient included type of renal vascular injury identified, type of embolic material and therapeutic outcome. Results: Renal vascular lesions identified in 119 patients were treated with embolization with complete resolution of hemorrhage, no further clinical deterioration and preservation of renal function. Conclusions: Renal vascular injury is a rare complication of percutaneous nephrolithotomy. Early renal angiography and selective embolization can play an integral diagnostic and therapeutic role.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2017, title = {The role of routine measurement of intra-abdominal pressure in preventing abdominal compartment syndrome}, author = {G. Raghavendra Prasad and J. V. Subba Rao and Amtul Aziz and T. M. Rashmi}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473297/?report=reader}, doi = {10.4103/jiaps.JIAPS_222_15}, issn = {0971-9261}, year = {2017}, date = {2017-09-30}, urldate = {2017-09-30}, journal = {Journal of Indian Association of Pediatric Surgeons}, volume = {22}, issue = {3}, pages = {134-138}, abstract = {Introduction: Abdomen, a closed compartment, is prone to raised intra-abdominal pressure (IAP) in the postoperative period. After a critical value of ≥ 15 cm of water, IAP produces abdominal compartment syndrome (ACS). ACS leads to reduced venous return, reduced cardiac output, and domino effect of organ dysfunction, leading to death. Hence, it is the need of hour to monitor IAP to pick up intra-abdominal hypertension (IAH) and ACS. This routine facilitates early institution of treatment measures. Aims and Objectives: To study IAP in abdominal operations in neonates, infants, and older children and to promote concept of routine measurement of IAP as standard care. Materials and Methods: Intravesical route was used to measure IAP in this prospective observational study. Seventy-nine pediatric abdominal surgeries met with criteria of availability of complete data for analysis and formed the cohort of the study. All major, infective, traumatic, tumor-related abdominal surgeries were included in the study. Outcome, C-reactive protein (CRP), procalcitonin, platelet counts, Simplified Sequential Organ Failure Assessment Score, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score were the parameters analyzed. The World Society of ACS grading was adopted in the study with subdivision of normal into low-normal and high-normal subgroups. Results: Extended Mantel–Haenszel Chi-square statistical tool when applied for linear relationship showed a linear relationship with outcome (P < 0.05), CRP (P < 0.05), procalcitonin (P < 0.05), Simplified Sequential organ failure Assessment Score, and APACHE II. Platelet counts (P > 0.05) were not significantly correlated. Decision for laparotomy was delayed in cases of ACS. Conclusion: Routine measure of IAP facilitates early recognition of IAH. This facilitates therapeutic measures to be initiated to reduce IAP. Early decision to decompress by laparotomy/laparostomy saves lives. Hence, routine IAP measurement should be a part of standard care in pediatric abdominal surgery.}, keywords = {Anesthesiology, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Baseera_2017, title = {A Prospective Study on drug prescribing pattern in hypertensive patients in a tertiary care teaching hospital at Hyderabad}, author = {Shafia Baseera and Shaheda Siddiqui and Urooj Ahmedi and Pramod Kumar Korani Ratnam}, url = {http://www.journalijcar.org/sites/default/files/issue-files/3865-A-2017.pdf}, doi = {10.24327/ijcar.2017.6204.0893}, issn = {2319-6475}, year = {2017}, date = {2017-09-28}, urldate = {2017-09-28}, journal = {International Journal of Current Advanced Research}, volume = {6}, issue = {9}, pages = {6200-6204}, abstract = {Background: Irrational drug prescribing is a common practice globally; it results in increased morbidity, mortality & economic burden on society. Drug utilisation studies are an important tool to promote rational prescribing. Aims & Objective: To study on drug prescribing pattern in hypertensive patients. Materials and Methods: A drug utilisation study was conducted in hypertensive patients by the department of pharmacology in medicine OPD at OHRC, Hyderabad, Telangana for 2 months. 153 prescriptions were evaluated for prescribing pattern by using WHO drug use indicators. Results: 153 prescriptions were analysed. A total of antihypertensive drugs were prescribed. 60 angiotensin receptor blockers (ARBs), 8 angiotensin converting enzyme (ACE) inhibitors, 43Beta blockers, 43 Calcium channel blockers, 29 Fixed dose combinations (FDCs) of antihypertensives were included. 1.20 drugs were prescribed per prescription. 8 out of the total 15 antihypertensive drugs that were mentioned in the essential drug list 2016-17 were prescribed. Conclusion: Most commonly prescribed drugs were ARBs and ACE inhibitors. Rational prescribing requires consideration of dose to duration and interaction with other medications. }, keywords = {Deccan School of Pharmacy, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{B_2017c, title = {Clinical profile of patients presenting with rhegmatogenous retinal detachment}, author = {Vijaya Lakhsmi B. and Irfan Faraz and Lokabhi Reddy J. M.}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_11.pdf}, doi = {10.26611/10093311}, issn = {2250-7575}, year = {2017}, date = {2017-09-26}, urldate = {2017-09-26}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {87-91}, abstract = {Background: The aim of the study was to evaluate the epidemiological characteristics, risk factors, characteristic of retinal detachment in patients presenting with rhegmatogenous retinal detachment. This study was conducted among patients presenting at Sarojini Devi Eye Hospital. Material and Methods: The study duration spanned over a period from august 2008 to September 2010. Patients presenting to the ophthalmology OPD and diagnosed with rhegmatogenous retinal detachment were included in the study Cases with recurrent retinal detachment, tractional retinal detachment, Combined retinal detachments, exudative retinal detachment. Secondary detachments after vitrectomy, strabismus or ocular surgeries were excluded from the study. Results: Fifty patients who were diagnosed with a rhegmatogenous retinal detachment were included in the study. Majority of the patients belonged to the age group of 40 to 60 (18, 36%) years with a mean age of 40 years. 29 patients(58%) were males. In 21 patients (42%) left eye was involved and in right eye was involved. In two patients both eyes were involved. 15 (30%) patients presented to the clinic within 2 weeks and 66 % of the patients presented within 5 weeks.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{B_2017b, title = {Tackling refractive surprise post cataract surgery–a surgeon’s nightmare}, author = {Vijaya Lakhsmi B. and Irfan Faraz}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_9.pdf}, doi = {10.26611/1009339}, issn = {2250-7575}, year = {2017}, date = {2017-09-21}, urldate = {2017-09-21}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {79-83}, abstract = {Cataract surgery is the most common surgery performed by ophthalmologists. The goal of surgery has shifted from restoring vision to providing a spectacle free vision. Refractive surprise post cataract surgery is one of the most frustrating event. In this article, we describe the measures to deal with refractive surprise post cataract surgery. The choice of treatment varies from non invasive modalities like spectacles to invasive procedures like IOL exchange, Laser vision correction etc.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Faraz_2017c, title = {Spectrum of diseases in ocular tuberculosis}, author = {Irfan Faraz and Vijaya Lakhsmi B. and Mutyala Gopal Kishan}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_8.pdf}, doi = {10.26611/1009338}, issn = {2250-7575}, year = {2017}, date = {2017-09-20}, urldate = {2017-09-20}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {75-78}, abstract = {Aim: To study the spectrum of diseases in ocular tuberculosis and their management and to determine the complications, prognostic factors and visual outcome in this disease. Material and Methods: In this retrospective study we present 10 patients presenting to ophthalmology department. Comprehensive evaluation was done in all patients.OCT and FFA was done in selected patients and routine systemic investigations were done in all patients. Observation and Results: Two patients had granulomatous anterior uveitis out of which 2 had cystoid macular edema, 2 had intermediate uveitis, 3 had retinal vasculitis All patients were started on topical steroids and cycloplegics. Oral steroids were given in patients with intermediate uveitis and retinal vasculitis after induction phase of ATT regimen. All patients were started on Anti-tuberculous treatment regime in collaboration with the pulmonologist. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{B_2017, title = {Management of microbial keratitis}, author = {Vijaya Lakhsmi B. and Irfan Faraz}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_6.pdf }, doi = {10.26611/1009336}, issn = {2250-7575}, year = {2017}, date = {2017-09-16}, urldate = {2017-09-16}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {66-70}, abstract = {Microbial keratitis is the one of the common causes of corneal blindness. It is defined as an epithelial defect with infiltrate. It can be caused by bacteria, virus, fungus, acanthamoeba. Detecting the exact causative organism to ensure prompt treatment is important. In this article we describe the evaluation, management (medical and surgical) of the microbial keratitis. We focus predominantly on bacterial and fungal ulcers in this article}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Faraz_2017b, title = {Ocular manifestations in systemic lupus erythematosus}, author = {Irfan Faraz and Vijaya Lakhsmi B. and Mutyala Gopal Kishan}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_4.pdf}, doi = {10.26611/1009334}, issn = {2250-7575}, year = {2017}, date = {2017-09-14}, urldate = {2017-09-14}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {58-61}, abstract = {Aim: To report the significance of ocular manifestations in Systemic lupus erythematosus Materials and methods: Seven diagnosed cases of Systemic lupus erythematosus, which included both newly diagnosed cases and cases already on treatment, were referred from the treating physician for ophthalmological evaluation. Comprehensive ophthalmic examination was done using BCVA, intraocular pressure measurement, Slit lamp examination of the anterior segment, fundus examination using Slit lamp biomicroscopy and indirect ophthalmoscopy, and Schirmers testing was done. In selected patients, certain special investigations like visual fields 24-2, 10-2 testing, SD-OCT was done. However ERG, could not be done due to lack of resource availability. Patients with history of Diabetes mellitus, Hypertension and other ophthalmic diseases like age related cataract were excluded. Results: Out of the seven cases of SLE examined, xerosis was the most commonly encountered manifestation, seen among 6 patients. Episcleritis was seen in one patient, Anterior uveitis seen in 2 patients, SLE associated retinopathy was seen in 3 patients. Treatment induced side effects like glaucoma was seen in 1 patient, posterior subcapsular opacities in 2 patients and Bull’s eye maculopathy suggestive of HCQ toxicity seen in 1 patient. While dryness, episcleritis and retinopathy were managed conservatively, Anterior uveitis was managed with topical steroids. Patients with HCQ associated toxicity were advised to stop the HCQ therapy or to go for an alternative regimen, those with posterior subcapsular opacities were advised cataract surgery, while glaucomatous patients were started on anti glaucoma therapy. Conclusion: Early diagnosis, prompt referral, coordinated treatment and long term follow-up through multi disciplinary approach involving Ophthalmologists, Rheumatologists and Dermatologist play a key role in reducing ocular and systemic morbidity associated with Systemic lupus erythematosus. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2017b, title = {Enhanced neuroprotective effect of mild-hypothermia with VPA against ethanol–mediated neuronal injury}, author = {Sandeep Kumar Vishwakarma and Avinash Bardia and Chandrakala Lakkireddy and Sana Arshiya and Syed Ameer Basha Paspala and Vishnupriya Satti and Aleem Ahmed Khan}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0040816617301374?via%3Dihub}, doi = {10.1016/j.tice.2017.09.004}, issn = {0040-8166}, year = {2017}, date = {2017-09-14}, urldate = {2017-12-01}, journal = {Tissue and Cell}, volume = {49}, issue = {6}, pages = {638-647}, publisher = {Elsevier BV}, abstract = {Introduction: Progress in understanding pathophysiological mechanisms and the development of targeted regenerative strategies have been hampered by the lack of predictive disease models, specifically for the conditions to which affected cell types are inaccessible. The present study has aimed to unearth the role of valproic acid (VPA) and mild hypothermia (MH) as promising strategy to enhance the neuroprotective mechanisms in undifferentiated and differentiated human neural precursor cells (hNPCs) against ethanol-induced damage. Methods: 5 mM VPA alone or in combination with MH (33 °C) was used to prevent the damage in proliferating and differentiating hNPCs. CD133 + ve enriched hNPCs were cultured in vitro and exposed to 1 M chronic ethanol concentration for 72 h and followed by VPA and MH treatment for 24 h. Morphometric analysis was performed to identify changes in neurospheres development and neuronal cell phenotypes. Flow cytometry and RT-qPCR analysis was performed to investigate alterations in key molecular pathways involved in cell survival and signaling. Results: Combination of VPA with MH displayed higher proportion of neuronal cell viability as compared to single treatment. Combination treatment was most effective in reducing apoptosis and reactive oxygen species levels in both the undifferentiated and differentiated hNPCs. VPA with MH significantly improved neuronal cell phenotype, active chromatin modeling, chaperon and multi-drug resistant pumps activity and expression of neuronal signaling molecules. Conclusion: The study provided an efficient and disease specific in vitro model and demonstrated that combined treatment with VPA and MH activates several neuroprotective mechanisms and provides enhanced protection against ethanol-induced damage in cultured undifferentiated and differentiated hNPCs.}, key = {pmid28947065}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Faraz_2017, title = {Combined pars plana vitrectomy and iris claw lens in management of dislocated cataract or IOL}, author = {Irfan Faraz and Vijaya Lakhsmi B. and Mutyala Gopal Kishan}, url = {https://www.medpulse.in/Ophthlmology/Article/Volume3Issue3/Ophthalmology_3_3_2.pdf}, doi = {10.26611/1009332}, issn = {2250-7575}, year = {2017}, date = {2017-09-11}, urldate = {2017-09-11}, journal = {MedPulse International Journal of Ophthalmology}, volume = {3}, issue = {3}, pages = {51-53}, abstract = {Aim: To report management of posteriorly dislocated cataractous lens/IOL with Combined Pars Plana Vitrectomy and Iris claw lens implantation. Method: This is a retrospective study of 6 cases of dislocated IOL(4) and cataractous lens(2) at a tertiary eye Hospital in Telangana between October 2016 and February 2017 .Two case each of nucleus drop and IOL drop occurred in our hospital. Rest were referred from outside. These six patients were subsequently taken up for secondary procedure after reduction of corneal edema and inflammation. Three port PPV was done in all cases with nucleus/IOL retrieval, Iris claw lens was implanted and surgical peripheral iridectomy. Section was sutured where necessary. All patients were followed up for minimum of 3 months post operatively. Results: All patients had uneventful post op recovery with BCVA of 6/12 - 6/9 at 3months postoperative followup. Long term results are yet to be evaluated. Observation: Iris claw lens along with PPV offers a safe, easy and affordable alternative as a secondary IOL in cases with posteriorly dislocated lens with no or inadequate capsular support. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Nazki_2017, title = {Total proteins, albumin and HbA1c in type 2 diabetes mellitus}, author = {Faizan I Asrar Nazki and Syyeda Anees and Sara Mohammed }, url = {https://www.medpulse.in/Biochemistry/html_3_3_1.php}, doi = {10.26611/1002331}, issn = {2550-763X}, year = {2017}, date = {2017-09-02}, urldate = {2017-09-02}, journal = {MedPulse International Journal of Biochemistry}, volume = {3}, issue = {3}, pages = {40-42}, abstract = {Type 2 diabetes mellitus is a metabolic disorder characterized by insulin resistance [affecting carbohydrate, lipid and protein metabolism]. Glycation of proteins, including hemoglobin and albumin have been implicated in complications of diabetes. The aim of the present study was to evaluate the association between variations in the levels of albumin and total proteins with glycated hemoglobin [HbA1c]. Present study involved 408 participants who visited Owaisi Hospital and Research Center, Hyderabad from November 2015 to June 2017. 204 were freshly detected diabetic patients and 204, age and sex matched healthy controls. Fasting blood glucose levels, HbA1c, plasma total proteins and plasma albumin were estimated. The objective was to analyze the association between total proteins, albumin and HbA1c in newly diagnosed cases of Type 2 Diabetes Mellitus. HbA1c levels increased (p<0.001) from 4.90 ± 0.53 in controls to 9.02 ± 2.06 in cases, plasma albumin levels were decreased (P<0.50) from 3.85 ± 0.68 in controls to 3.19 ± 1.07 in cases and plasma total protein levels were increased from 6.8±0.81 in controls to 7.31±0.93 [p< 0.0013*] in cases. Globulin levels increased (P<0.50) from 1. 68 ± 0.29 in controls to 1.74 ± 0.57 in cases. A/G ratio levels decreased (P<1.20) from 2.31 ± 0.43 in controls to 1.84± 0.36 in cases. Glycation accelerates albumin degradation via increasing catabolic rate and decreasing protein half-life, and competes with other proteins for glycation. Our study showed a negative correlation between HbA1c and serum albumin. Freshly detected diabetic patients were associated with increased total proteins and decreased A/G ratio. We observed in our study that albumin levels may be associated inversely with HbA1c values. Our results may lead us to study the ways in which glucose and proteins may interact in a newer approach and could aid in understanding hyperglycemia and its estimation.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Afsar_2017, title = { Role of mean platelet volume as an adjunct in evaluation of acute inflammation}, author = {Nabila Afsar and Idrees Akhtar Afroze and Habeebunnisa Tahniath and Zakia Abid}, url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/apalm1486/pdf_416}, doi = {10.21276/APALM.1486}, issn = {2349-6483}, year = {2017}, date = {2017-09-01}, urldate = {2017-09-01}, journal = {Annals of Pathology and Laboratory Medicine}, volume = {4}, issue = {4}, pages = {A466-A469}, abstract = {Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker.Methods: A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis.Conclusion: MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis.}, keywords = {Pathology}, pubstate = {published}, tppubtype = {article} } @article{Faisaluddin_2017, title = {Controversies in serotonin syndrome diagnosis and management: a review}, author = {Mohammed Faisaluddin and Richard Alweis and Syed Raza Shah and Noman Lateef and Waqas Shahnawaz and Rohan Kumar Ochani and Amin Muhammad Dharani and Syed Arbab Shah}, url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2017&volume=11&issue=9&page=OE05&issn=0973-709x&id=10696}, doi = {10.7860/jcdr/2017/29473.10696}, issn = {0973-709X}, year = {2017}, date = {2017-09-01}, urldate = {2017-01-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {11}, issue = {9}, pages = {OE05-OE07}, publisher = {JCDR Research and Publications}, abstract = {Over the past few years, Serotonin Syndrome (SS) has become a significant clinical concern. Over the last decade, United States saw a surge in antidepressant use. SS characteristically presents as the triad of altered mental status, autonomic dysfunction and neuromuscular excitation. Symptoms vary from patient to patient with mild cases presenting with subacute symptoms and severe cases progressing rapidly to death. Due to the protean manifestations of the syndrome along with non-specific prodromal, SS can easily be misdiagnosed if not carefully assessed. In severe cases, SS can be mistaken as neuroleptic malignant syndrome while mild cases are mostly misattributed to other causes such as flu. SS is a clinical diagnosis and therefore, requires a thorough review of medications and physical examination. Given the protean nature of this toxicologic syndrome various criteria were defined which includes Sternbach’s, Radomski and Hunter’s criteria. Keeping in mind the wide symptoms of serotonin syndrome from being barely perceptible to lethal emphasis there is a need to treat the syndrome on urgent basis. Mainstay for treatment of serotonin syndrome is to discontinue the offending drug. Improvement is seen in most patients within 24 hours.}, key = {pmid29207768}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Khan_2017, title = {Role of intratympanic dexamethasone injection as a treatment choice of patients with immune-mediated sensorineural hearing loss a clinical study}, author = {Imtiaz Ahmed Khan and Urooj Ahmed Choudhary}, url = {http://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_sep_oa14_-_2017.pdf}, doi = {10.17354/ijss/2017/455}, issn = {2321-595X}, year = {2017}, date = {2017-09-01}, urldate = {2017-09-01}, journal = {International Journal of Scientific Study}, volume = {5}, issue = {6}, pages = {81-84}, abstract = {Background: Sensorineural hearing loss (SNHL) is not an uncommon condition encountered in ENT practice. Once developed in patients, it causes severe handicap that affects their job, family life, and social life. Therefore, once diagnosed the otologists should treat the disorder effectively to improve and/or even stabilize hearing. Aim: To evaluate the role of intratympanic corticosteroids for the treatment of different types of SNHL. Materials and Methods: A total of 68 patients with immune-mediated SNHL were subjected to intratympanic steroid injections under local anesthesia. Pre- and post-injection Audiological evaluation; pure tone average (PTA) was done to know the results. Observations and Results: Hearing improvement with improved PTA of 26.20 dB by pure tone audiometry observed in 49.42% of the patients. Improved speech discrimination scores of 37.60% in 58.4% of patients. Conclusion: In SNHL of immune-mediated pathogenesis intratympanic steroid injection remains a safe and effective tool in the armamentarium of an ENT surgeon. }, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Choudhary_2017, title = {Brain stem evoked response audiometry responses in tinnitus patients - a study on auditory evaluation in a tertiary teaching hospital of Hyderabad}, author = {Urooj Ahmed Choudhary and Imtiaz Ahmed Khan}, url = {http://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_sep_oa06_-_2017.pdf}, doi = {10.17354/ijss/2017/447}, issn = {2321-595X}, year = {2017}, date = {2017-09-01}, urldate = {2017-09-01}, journal = {International Journal of Scientific Study}, volume = {5}, issue = {6}, pages = {30-34}, abstract = {Background: The cause of tinnitus is theorized as due to abnormal spontaneous nerve activity somewhere along the auditory pathway. Majority of the causes of such neuronal activities are unknown. Auditory evaluation is done in all patients with tinnitus to rule out organic brain diseases which may also cause tinnitus. Brain stem evoked response audiometry (BERA) is one such test in the armamentarium of audiological evaluation laboratory. Aim: The aim of the study is to study the results of BERA performed in all patients undergoing audiological evaluation for tinnitus. Materials and Methods: Patients were divided into two groups; 78 patients with tinnitus and 34 normal individuals as control group. Total audiological evaluation was done in individuals of both groups. Absolute latencies of Wave I, III, and V, inter peak latencies (IPLs) as well as the interaural latency difference of Wave V (ILD-V) was recorded. Observations and Results: There was no statistical significant difference between both groups. Few tinnitus patients showed abnormal prolonged absolute latencies, IPLs, and increased ILD-V. There was some asymmetry in results between different study subgroups. Conclusions: BERA results can variable in tinnitus patients. Few patients have normal results while others showed prolonged absolute or IPLs or increased ILD-V difference. }, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Mohammed_2017, title = {Correlation of 24-hour urinary protein, urinary protein: creatinine ratio and HbA1c in type 2 diabetes with and without nephropathy}, author = {Sara Mohammed and Syyeda Anees and Faizan I Asrar Nazki }, url = {https://www.medpulse.in/Biochemistry/Article/Volume3Issue2/Bio_3_2_2.pdf}, doi = {10.26611/1002322}, issn = {2550-763X}, year = {2017}, date = {2017-08-18}, urldate = {2017-08-18}, journal = {MedPulse International Journal of Biochemistry}, volume = {3}, issue = {2}, pages = {29-33}, abstract = {Background: The leading cause of morbidity and premature mortality in diabetics is nephropathy. Glycemic control is closely associated with renal involvement in diabetes. Proteinuria is an important clinical sign in Diabetic Nephropathy. Objectives: To estimate serum levels of HbA1c, 24- hour urinary protein concentration and urinary protein: creatinine ratio in Type 2 diabetics with and without nephropathy. To assess correlation between protein: creatinine ratio, 24-hour urinary protein and HbA1c levels in these groups. Materials and Methods: Cross sectional study was conducted in the department of Biochemistry, Owaisi Hospital, from October 2016 to May 2017 on 103 diabetes patients comprising of 41 diabetics without nephropathy (Group A) and 62 Type 2 diabetes subjects with nephropathy (Group B). The following parameters were estimated: Fasting blood glucose, Serum creatinine, HbA1c, Urinary protein and creatinine. Results: Results show that the mean values of fasting blood glucose, serum creatinine, HbA1c, 24-hour urinary protein and protein to creatinine ratio are significantly increased in Group B when compared to Group A and these parameters are further increased in diabetic subjects with P: C ratio ≥ 0.2 than those with <0.2 Result: 24-hour urinary protein and protein: creatinine ratio levels are significantly increased (p< 0.001) with proteinuria more than the physiological range (P: C ratio 0.2) than within physiological range (P: C < 0.2).24- hour urinary protein and P:C ratio also correlated positively with high significance.HbA1c levels correlated positively with both P:C ratio and 24-hour urinary protein levels. Conclusion: This study suggests estimating HbA1c as an indicator of glycemic control .P:C ratio is convenient method for early diagnosis and intervention for diabetic nephropathy.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2017, title = {Use of biocompatible sorafenib-gold nanoconjugates for reversal of drug resistance in human hepatoblatoma cells}, author = {Sandeep Kumar Vishwakarma and Priyanka Sharmila and Avinash Bardia and Lakkireddy Chandrakala and N. Raju and G. Sravani and B. V. S. Sastry and Md. Aejaz Habeeb and Aleem Ahmed Khan and Marshal Dhayal}, url = {https://www.nature.com/articles/s41598-017-08878-y.pdf}, doi = {10.1038/s41598-017-08878-y}, issn = {2045-2322}, year = {2017}, date = {2017-08-17}, urldate = {2017-08-01}, journal = {Scientific Reports}, volume = {7}, issue = {1}, pages = {1-12}, publisher = {Springer Science and Business Media LLC}, abstract = {The present study identifies the potential of highly biocompatible SF-GNP nano-conjugate to enhance the chemotherapeutic response to combat drug resistance in cancer cells. We developed a stable colloidal suspension of sorafenib-gold nanoconjugate (SF-GNP) of <10 nm size in aqueous medium for reverting the cancer drug resistance in SF-resistant HepG2 cells in a 3D ex-vivo model system. In-vivo biocompatibility assay of SF-GNPs showed absence of systemic toxicological effects including hematological, biochemical and histological parameters. More importantly, the histopathological analysis of vital organs such as liver, brain, lung, kidney and heart showed very least or no sign of inflammation, cell infiltration, necrosis, tissue disorganization or fibrotic reactions after intra-peritoneal administration of SF-GNP nanoconjugates in animals. However, SF-GNP nanoconjugates significantly reduced (>80%) the percentage cell survival and the size and number of SF resistant solid tumor colonies of HepG2 cells in 3D model system. The exposure of SF-GNP nanoconjugate to SF resistant HepG2 cell colonies also provided evidence for anti-proliferative effect and reversal of drug resistance by elucidating the molecular regulatory mechanisms of extracellular matrix factor (CD147), tumor growth factor (TGF-β), hepatoma upregulated protein (hURP) and drug transporter (ABCG-2).}, key = {pmid28819176}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Ravi_2017b, title = {Flap closure for gluteal pilonidal sinus-is it an economically viable option?}, author = {Ganji Ravi and Akshan Ugale and Nikhilesh Vedire and Soumya Chauhan and Prasad B. L. Ch. and Ali Mohammed Syed}, url = {https://www.jebmh.com/articles/flap-closure-for-gluteal-pilonidal-sinus-is-it-an-economically-viable-option.pdf.pdf}, doi = {10.18410/jebmh/2017/777}, issn = {2349-2562}, year = {2017}, date = {2017-08-11}, urldate = {2017-08-11}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {4}, issue = {65}, pages = {3889-3894}, abstract = {BACKGROUND: Flap closure technique for sacrococcygeal pilonidal sinus disease has been conclusively shown to be effective in relieving recurrence rate in many studies, but it is expensive and difficult to perform. Purpose of this study is to find out if simple primary closure is effective in management as claimed by some authors and to determine which of the procedures is easier on the pocket for the patient. MATERIALS AND METHODS: Patients were enrolled into either of the two groups- Group A- Simple primary closure. Group B- Flap closure and gluteal sulcus obliterative procedures based on their choice after explaining the type of procedure and the approximate cost involved in both. Parameters recorded and analysed by Pearson’s Chi-square test for statistical significance. RESULTS: 95 patients were included for the study- 42 in Group A and 53 in Group B. Male-to-female ratio of 5:2 and 11:4, respectively; average age of 25 in both the groups (range 15 to 40 years in group A, 16 to 41 in group B). There were 17 wound dehiscence, 2 seromas and 7 recurrences in group A and 16 wound dehiscence, 8 seromas and 2 recurrences in group B. The difference is the recurrence rate being statistically significant. 12 patients- 8 with non-healing wounds and 4 with recurrences from group A joined group B while 9-6 with dehiscence and 3 recurrences were lost to follow up. Average wound healing time in the simple closure patients was 31 days, while in group B, it was 16.4 days. Average expenditure incurred by patients in primary closure group was Rs. 7,900 compared to Rs. 9,300 in group B, but if the additional expense due to crossing over to group B was added, average jumped up to Rs. 10,700, which was Rs. 1000 more than the flap closure patients. CONCLUSION: In management of patients with chronic sacrococcygeal pilonidal sinus, even though the average cost of treatment by simple primary closure is less than that by flap closure technique, the significantly higher rate of recurrence and prolonged time to heal in case of wound dehiscence nullifies whatever pecuniary benefits they may have gained and hence flap closure is advisable especially in patients with recurrent disease.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Marupaka_2017, title = {Intraarticular injuries in pediatric knee in relation to physeal closure- an MRI study}, author = {Sravan Kumar Marupaka and Kazi Amir Irfan and G. Raghavendra Prasad and Jampala Venkateshwarlu and Anand Abkari and Mohammed Naseeruddin}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/August_2017_1501589395__63.pdf}, issn = {2249-555X}, year = {2017}, date = {2017-08-01}, urldate = {2017-08-01}, journal = {Indian Journal of Applied Research}, volume = {7}, issue = {8}, pages = {173-176}, abstract = {INTRODUCTION: It is found that ACL injury in younger age is a significant public health burden with gradually rising incidence over the last decade. Present study is about the incidence of ACL injuries and associated meniscal and osteochondral injuries in children aged less than 18years with comparison of the pattern of various injuries before and after closure of physes. MATERIAL AND METHODS: Children were divided into two groups depending on the status of closure of the physis. Intra articular injuries involving cruciate ligaments, menisci and articular cartilage were analyzed for prevalence in relation to the skeletal maturity. RESULTS: Complete rupture including avulsion was significantly more common in mature skeleton and partial tears were more common in immature skeleton with a p value of 0.039 (less than 0.05). CONCLUSION: Commonest injuries involved ACL followed by medial meniscal tears, osteochodral lesions and lateral meniscal injuries.}, keywords = {Pediatric Surgery, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Koganti_2017, title = {Report of two rare cases of Kindler‘s syndrome in siblings}, author = {Neha Chowdary Koganti and Nayeem Sadath Haneef and Fatima Razvi and B. Y. Praveen Kumar and Nikhat Fatima and Mohammed Altamash Zubair and Debasmita Chakraborty}, url = {https://jmas.in/fulltext/154-1488641936.pdf?1675745562}, doi = {10.5455/jmas.260417}, issn = {2231-1696}, year = {2017}, date = {2017-07-31}, urldate = {2017-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {7}, issue = {2}, pages = {118-121}, abstract = {Kindler’s syndrome is a rare autosomal recessive disorder. It is characterized by trauma-induced blistering, photosensitivity, poikiloderma and mucosal inflammation. It occurs due to mutation on chromosome 20p. This report describes two siblings with history of blistering and photosensitivity in childhood and later developed poikiloderma with histopathology of effected skin showing features of poikiloderma.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Zubair_2017, title = {Report of three rare cases of Dowling Dego's disease}, author = {Mohammed Altamash Zubair and Nayeem Sadath Haneef and Fatima Razvi and B. Y. Praveen Kumar and Nikhat Fatima and Neha Chowdary Koganti}, url = {https://jmas.in/fulltext/154-1489068283.pdf?1675745759}, doi = {10.5455/jmas.260932}, issn = {2231-1696}, year = {2017}, date = {2017-07-31}, urldate = {2017-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {7}, issue = {2}, pages = {122-125}, abstract = {Dowling Dego’s disease is a rare autosomal dominant condition. It is caused by loss of function mutations in keratin 5 gene (kRT5) situated in keratin gene cluster on 12q13. We are reporting three cases of Dowling Dego’s disease out of which two belong to same family. The clinical manifestations and histopathology were analyzed. All the three patients of which two were mother and son had symmetric, reticulate hyperpigmentation, pitted scars and acneiform eruption over face (predominantly perioral area, nasolabial folds), pinnae, upper trunk, thighs were seen. Palms, soles and scalp were spared. Buccal mucosa also showed reticulate hyperpigmentation. In addition the female patient had vulval reticulate hyperpigmentation and hydradenitis suppurativa affecting axillae, groins and inframammary folds. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Chakraborty_2017, title = {A case report showing coexistence of two autoimmune diseses- psoriasis and vitiligo}, author = {Debasmita Chakraborty and Nayeem Sadath Haneef and Fatima Razvi and B. Y. Praveen Kumar and Nikhat Fatima and Neha Chowdary Koganti and Mohammed Altamash Zubair}, url = {https://jmas.in/fulltext/154-1488293321.pdf?1675746895}, doi = {10.5455/jmas.260021}, issn = {2231-1696}, year = {2017}, date = {2017-07-31}, urldate = {2017-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {7}, issue = {2}, pages = {114-117}, abstract = {Psoriasis and vitiligo are autoimmune diseases. Occurrence of both these diseases in the same patient, especially at same sites is uncommon. Here, one such patient having both psoriasis and vitiligo lesions at the same site is being reported. An eight year old male patient presented with asymptomatic flat, white coloured, lesions over the left knee joint and left elbow joint since 3 years, followed by the appearance of multiple, asymptomatic red, scaly, elevated lesions over the pre-existing lesions since 10 days. There was no history of atopy, or drug intake/any applications or joint pains in this patient. There was family history of similar white coloured lesions and hypothyroidism. Cutaneous examination revealed well defined, polysized, depigmented macules measuring around 5x3 cm with leukotrichia affecting the left knee joint and the left elbow joint. There were multiple, well defined, erythematous, plaques measuring around 2x2cm with silvery white scales over the extensor aspect of left elbow joint and left knee joint within the depigmented macules. Auspitz’s sign (peeling and pinpoint bleeding spots over the lesion on scrapping with a glass side) was positive. There was sparing of genitalia, palms, soles and scalp. Hair and nail was normal. A provisional diagnosis of vitiligo associated with psoriasis vulgaris was made, which was confirmed on histopathology. Both psoriasis and vitiligo lesions were treated accordingly. Occurrence of both vitiligo and psoriasis in the same patient and at same sites indicates similar etiopathogenesis. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2017, title = {Sleep Apnea}, author = {Nazia Uzma and Vontela Devender Reddy}, url = {https://www.nepjol.info/index.php/JGMCN/article/view/17863}, doi = {10.3126/jgmcn.v9i2.17863}, issn = {2070-4240}, year = {2017}, date = {2017-07-31}, urldate = {2017-07-01}, journal = {Journal of Gandaki Medical College-Nepal}, volume = {9}, issue = {2}, pages = {29-37}, publisher = {Nepal Journals Online (JOL)}, abstract = {Background: Sleep apnea is a condition that interrupts breathing while sleeping, usually caused by an obstruction blocking the back of the throat so that the air cannot reach the lungs. The brief cessation in breath automatically forces individuals to wake up and restart breathing. This can happen many times during the night, making it hard for the body to get enough oxygen, and impacts the sleep quality. It is the most common type of sleep disorder breathing. Objectives: The present study was designed to investigate the effects of obstructive sleep apnea (OSA) on different mental, physical and nervous disorders which are manifested in such patients. This study would not only benefit in ascertaining the causes of OSA through assessment of higher mental functions of autonomic and peripheral nervous systems but also in the development of algorithm for estimation of degree of damage to the nervous system with severity of OSA. Methods: A total of 1365 consecutive participants participated in this study at the Department of Pulmonary Medicine, Deccan College of Medical Sciences, Hyderabad, Telangana State, India for suspected sleep disordered breathing (SDB) between October 2012 and February 2016. In this cohort, 1140 participants were deemed ineligible, as per the inclusion criteria. Therefore, 225 patients were considered in the study along with 75 control subjects, who were healthy individuals. The cohort was diagnosed by an experienced pulmonologist for the symptoms of snoring and daytime somnolence. The data included documentation of age, gender, weight, height, BMI, waist and neck circumference, and clinical data such as history of apnea, insomnia, dyslipidemia, hypertension, and coronary heart disease. All participants underwent overnight polysomnography (PSG) in sleep laboratory. The cognitive function tests consisted of mini-mental state examination and by employing the depression questionnaire (Using Zung self report depression scale). The autonomic function tests were performed. Variabilities in heart rate were determined. Brain natriuretic peptide (BNP) levels in the blood were measured. Results: The study group had an AHI ≥5 per hour of sleep while the control group had AHI <5 per hour of sleep. Overall, patients in the OSA cohort were older compared to those in the Control cohort. The overnight polysomnography values indicated distinct differences among the parameters of the analysis depending upon the category of the patient (i.e., mild, moderate and severe). Oxygen saturation in blood during both REM and NREM sleep stages clearly indicated lower oxygen in patient cohort than the control group. The cognitive function tests revealed that in comparison to the control group, OSA patients had significantly impaired cognition. OSA patients had significantly higher (p ≤0.05) depression. Motor action, muscle action potential and nerve action potential was significantly lower (p ≤0.05) than that of the control group of healthy patients. The plasma BNP in OSA patients was significantly higher (p ≤0.05) than control subjects. RR intervals in the patient group were significantly shorter than in the control group. The blood pressure of the OSA patients in general was relatively higher than the control group, both during the postural response and in handgrip test. Conclusions: Among the enrolled individuals, those with severe OSA were affected in all faculties, namely, cognitive abilities and health attributes; and had high BNP levels in their blood. In aggregate, OSA patients can be alleviated from the syndrome, if accurate diagnosis is made on time. This study developed an algorithm which would aid the clinicians in early detection of OSA symptoms and mitigate the prognosis of the syndrome.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Lodhi_2017, title = {Impact of early addition of teneligliptin to metformin in type 2 diabetic patients}, author = {Mohammed Mansoor Ali Khan Lodhi and Anjum Sultana Khatoon}, url = {https://www.ijcmr.com/uploads/7/7/4/6/77464738/1529_jul_22.pdf}, issn = {2393-915X}, year = {2017}, date = {2017-07-19}, urldate = {2017-07-19}, journal = {International Journal of Contemporary Medical Research}, volume = {4}, issue = {6}, pages = {2454-2459}, abstract = {Introduction: Diabetes is a noncommunicable disease. Present study assessed the effectiveness of early addition of Cost effective teneligliptin to Metformin in Type 2 Diabetes Mellitus patients. Material and Methods: 100 subjects were enrolled, of which only 28 subjects were eligible for the study. The study group comprised of 28 subjects who were on metformin monotherapy i.e. between 1000gms to 2000gms per day. 500 mg of metformin in the study group was replaced with DPPIV inhibitor- teneligliptin 20mg per day. In order to study the efficacy of combination therapy versus metformin monotherapy Paired t test was performed after completion of 12weeks of therapy. Result: The efficacy of combination therapy was assessed by Paired t test. It was observed that the mean FBS after addition of teneligliptin was (109.36 mg/dl ± 10.92) when compared to (118.07mg/dl ±12.76) in the Metformin monotherapy (t value:4.98; p value <0.001) there was significant decrease in Fasting blood glucose level after addition of teneligliptin. The mean PPBS after addition of teneligliptin was (182.61 mg/dl ±33.05) when compared to (203.18mg/dl ±38.04) in the Metformin monotherapy (t value: 7.76; p value <0.001) there was significant decrease in post prandial blood glucose level after addition of teneligliptin. The mean baseline HbA1c after addition of teneligliptin was (7.44% ±0.35) when compared to (7.65% ±0.38) in the Metformin monotherapy (t value: 7.12; p value <0.001) there was significant decrease in HbA1C level after addition of teneligliptin. The incidence of Gastro-intestinal adverse events was more in metformin monotherapy than addition of teneligliptin however it was not statically significant. In addition there was no statically significant change observed with respect to lipid profile, body weight, Insulin Levels and HOMA score. Conclusion: Teneligliptin was selected for the study because it has longer half-life, dual mode of elimination, superadded it is cost effective and cheaper in India than compared to other DPPIV inhibitors, due to its cheaper cost the compliance was better with respect to usage of teneligliptin. Ultimately Teneligliptin add-on to Metformin during the early course of treatment would be a multimodal approach in treatment of Diabetic patients further it could help in delaying the exhaustion of pancreatic islet function.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Faheem_2017, title = {Levels of serum magnesium in normal persons and persons suffering from viral hepatitis and diabetes mellitus-a comparative study}, author = {Raisa Faheem and Anjum Sultana Khatoon}, url = {https://www.jebmh.com/articles/levels-of-serum-magnesium-in-normal-persons-and-persons-suffering-from-viral-hepatitis-and-diabetes-mellitus--a-comparat.pdf.pdf}, doi = {10.18410/jebmh/2017/688}, issn = {2349-2562}, year = {2017}, date = {2017-07-15}, urldate = {2017-07-15}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {4}, issue = {57}, pages = {3456-3458}, abstract = {BACKGROUND: The Magnesium is the fourth most abundant cation in the body, second most abundant cation of the intracellular fluid and is known to be intimately associated with a variety of metabolic events. Magnesium is one of the most vital elements in biologic systems. In the plant world, it is the key element of chlorophyll. In the animal world, it is essential for many vital enzyme systems among which is the activation of membrane bound adenosine triphosphates. This enzyme system deals with energy production through oxidative phosphorylation and with distribution of sodium and potassium across the cell membrane. MATERIALS AND METHODS: The patients admitted in Owaisi Hospitals & Research Centre, Hyderabad were clinically investigated and pathological proved have been selected for the present study of serum magnesium estimation. In the present case 22 cases of viral hepatitis and 40 cases of normal (control) were considered and (40 normal individuals, 30 males and 10 females were studied to serve as controls and 15 cases of diabetes mellitus are studied in the present case. RESULTS: The present study presents the data on level of serum Magnesium in normal and diseased persons (Viral Hepatitis). The results reveal that the mean serum magnesium levels are found to be higher in Viral Hepatitis and in diabetes mellitus in Comparison with that of Control (Normal) Group. CONCLUSION: This study has shown that the mean Serum Magnesium Level were higher in cases of Viral Hepatitis and in diabetes mellitus in comparison with the normal control group. }, keywords = {Biochemistry, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Shah_2017b, title = {Evolocumab to reduce cardiovascular events: results of the FOURIER multinational trial}, author = {Syed Raza Shah and Mohd Faisaluddin and Noman Lateef and Amin Muhammad Dharani and Waqas Shahnawaz and Ahmed Nabeel Kazi and Syed Arbab Shah}, url = {https://www.tandfonline.com/doi/epdf/10.1080/20009666.2017.1340732?needAccess=true}, doi = {10.1080/20009666.2017.1340732}, issn = {2000-9666}, year = {2017}, date = {2017-07-13}, urldate = {2017-07-01}, journal = {Journal of Community Hospital Internal Medicine Perspectives}, volume = {7}, issue = {3}, pages = {199-200}, key = {pmid28808518}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Jalees_2017, title = {Study of malondialdehyde and estimation of blood glucose levels in patients with diabetes mellitus with cataract}, author = {Syeda Shahana Jalees and M. Rosaline}, url = {https://www.ijcbr.in/journal-article-file/4718}, doi = {10.18231/2394-6377.2017.0074}, issn = {2394-6369}, year = {2017}, date = {2017-07-11}, urldate = {2017-07-11}, journal = {International Journal of Clinical Biochemistry and Research}, volume = {4}, issue = {3}, pages = {319-323}, abstract = {Increased oxidative stress may contribute to development of complications in diabetes may result from over production of precursors to reactive oxygen radicals and/ or decreased efficiency of inhibitory scavenger systems. Senile diabetic cataract is one of the chronic complications of diabetes mellitus. The present study has been carried out in patients suffering with NIDDM (Type-2) with or without associated cataract. Hyperglycemia causes oxidative stress, as measured by malondialdehyde (MDA) (a lipid peroxidation product) is more in diabetic patients (370.80 n.mol/l) compared to the normal individuals (181.04 n.mol/l) whereas the oxidative stress in diabetics with cataract is significantly more (399.12 n.mol/l) than that in diabetics without complications. Attempts have been made under present study to estimate serum MDA levels as a marker of free radical stress against free radical injury.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{DeSouza_2017, title = {Study of psychiatric morbidity in cancer patients in teaching hospital}, author = {Rene De Souza and Syed Mateen}, url = {https://www.ipinnovative.com/journal-article-file/4440}, doi = {10.18231/ 2455-8559.2017.0008}, issn = {2455-8559}, year = {2017}, date = {2017-06-30}, urldate = {2017-06-30}, journal = {Telangana Journal of Psychiatry}, volume = {3}, issue = {1}, pages = {33-37}, abstract = {Introduction: Cancer is a leading cause of death worldwide. Co morbidity of cancer and psychiatric disorders can be as a result of the disease itself or due to associated problems. Aim: To know the prevalence of psychiatric disorders in patients suffering from cancer and its relation to the awareness of cancer. Materials and Method: 245 patients diagnosed with carcinoma referred to the department of psychiatry were selected for the study. Mini International Neuropsychiatric interview-plus{MINI-plus} was used to diagnose psychiatry morbidity and awareness of cancer was assessed by the interviewer using a questionnaire. Results: Out of 245 patients, 113 patients had Psychiatric disorders. The mean age of the patients was 53.7 ± 9.8 years. Breast cancer 41.3% is most common cancer observed while GIT related cancer are second common cancer. Major Depressive Disorder (28.3%) and adjustment disorders (26.6%) are most common psychiatric disorder found in the study population. Presence of psychiatric disorders is more in patients who are aware of cancer diagnosis which is highly significant (p=<0.05). Conclusions: There is strong relationship between presence of Psychiatric disorders and awareness of cancer. }, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Ajaz_2017, title = {Surgical management of fracture neck of femur in elderly adults with cemented bipolar hemiarthroplasty}, author = {Shaik Ajaz and Ramesh Bengaluri and Chavva Shamsunder}, url = {https://www.orthopaper.com/archives/2017/vol3issue3/PartP/3-3-72-283.pdf}, doi = {10.22271/ortho.2017.v3.i3p.167}, issn = {2395-1958}, year = {2017}, date = {2017-06-20}, urldate = {2017-06-20}, journal = {International Journal of Orthopaedics Sciences}, volume = {3}, issue = {3}, pages = {1157-1165}, abstract = {To study the functional outcome of fracture neck of femur treated with cemented bipolar hemiarthroplasty, post operative time required for mobilization of the patient, complications related to this procedure and to study the quality of life after hemireplacement arthroplasty using cemented bipolar endoprosthesis in 20 Patients who have sustained an intracapsular femoral neck fracture and are admitted in Deccan College Of Medical Sciences (PEH) and finally evaluated by Harris Hip Score.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Hassan_2017, title = {A comparative study of different adjuvants to augment the effect of epidural bupivacaine for lower abdominal surgeries}, author = {Khaja Ali Hassan and Mahmood Mirza and Mazherullah Khan and Zara Batool and Mohammed Sirajuddin}, url = {https://www.medpulse.in/Anesthsiology/Article/Volume2Issue3/Anes_2_3_1.pdf}, doi = {10.26611/1015231}, issn = {2579-0900}, year = {2017}, date = {2017-06-12}, urldate = {2017-06-12}, journal = {MedPulse International Journal of Anesthesiology}, volume = {2}, issue = {3}, pages = {46-49}, abstract = {Background: The technique of epidural anesthesia and analgesia have become widespread following their introduction and acceptance by the patients in surgical and obstetric practice. Adjuvants to bupivacaine have been used to enhance good quality perioperative and postoperative anesthesia and analgesia. The aim of the study is to evaluate the effect of extradural administration of bupivacaine, bupivacaine with fentanyl (2microgram/kg), ketamine (1mg/kg) and dexmeditomedine (1.5microgram/kg). Aim: The aim of the study is to evaluate the effect of extradural administration of bupivacaine, bupivacaine with fentanyl(2 microgram/kg), ketamine(1mg/kg) and dexmeditomedine (1.5microgram/kg). Methods: The prospective, comparative, single blind study includes 100 patients of ASA grade 1 and 2 for lower abdominal surgeries. Each group was given loading dose of 20ml of 0.5% bupivacaine with various adjuvants-fentanyl(2microgram/kg), or ketamine (1mg/kg) or dexmeditomedine (1.5microgram/kg) Result: Time of onset was earlier in group with ( bupivacaine +fentanyl) and (bupivacaine+dexmeditomedine). It was delayed in group of plain bupivacaine. The total power regained was delayed in bupivacaine+dexmeditomedine-260.8±18.77,bupivacaine+fentanyl-241.70±24.98 ,bupivacaine+ketamine-234.232±9.66 when compared to plain bupivacaine of 183.07±14.53(P <0.05).Demand of analgesia is earlier in plain bupivacaine and (bupivacaine+ketamine) when compared to (bupivacaine + fentanyl) and (bupivacaine+dexmeditomedine) requiring an early top up of epidural .Similarly two segment regimen is also significantly early in group (plain bupivacaine) and (bupivacaine+ketamine) (P<0.001). It is also observed that patients are hemodynamically stable with bupivacaine + fentanyl > bupivacaine + dexmeditomedine >plain bupivacaine>bupivacaine +ketamine. Conclusion: Fentanyl and dexmeditomedine were effective and superior as compared to plain bupivacaine(bupivacaine+ketamine) as an adjuvant to enhance effect of bupivacaine for epidurals.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2017, title = {An assessment of activities of daily living among depressed elderly using Katz index}, author = {Mohammed Sarosh Ahmed and Fawwad M. Shaikh and Padmaja R. Walvekar and Sameeran S. Chate and M. D. Mallapur}, url = {https://www.semanticscholar.org/paper/An-Assessment-of-Activities-of-Daily-Living-among-Ahmed-Shaikh/8236dde6207d03f3437c3707fe02cb9419dc8f98}, issn = {2347-5455}, year = {2017}, date = {2017-06-01}, urldate = {2017-06-01}, journal = {Annals of Community Health}, volume = {5}, issue = {2}, pages = {7-10}, abstract = {Introduction: Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, decreased energy, feelings of guilt or low self-worth, disturbed sleep or appetite, and poor concentration. Due to this, the physical and social aspects of health are affected. Depression in elderly reduces their quality of life to a great extent making them dependent in performing activities of daily living (ADL). If this problem is not addressed, it may result in increased suffering, dysfunction, morbidity, and economic burden not only on the individual but also on the family and the nation as a whole. Aims and Objectives: The aim of the study was to assess the ADL among depressed elderly and identify the associated risk factors. Methodology: A cross-sectional study was done among 850 participants aged 60 years and above residing in Ashok Nagar area, Belagavi. Data were collected by house to house visit using a predesigned questionnaire, which included sociodemographic details, KATZ ADL scale and geriatric depression scale-15 (GDS- short form). Statistical analysis was done by applying Chi-square test and multiple logistic regression analysis. Results: The prevalence of depression using GDS-15 was found to be 36.7%, with a higher preponderance in women than men (40.8% and 32.3%), respectively. Among the depressed elderly, the overall dependence in ADL was found to be 110 (35.3%). Complete dependence in ADL was found to be in 9 (2.9%) participants, and partial dependence was found in 101 (32.4%). Dependence among depressed elderly was found to be significantly associated with advancing age, female sex, lower socioeconomic status, unmarried status, and sedentary lifestyle (P < 0.05). Conclusion: Our study demonstrated a significant higher prevalence of dependence among depressed elderly and identified its risk factors in an urban population of South India. Urgent steps are needed to be taken at the earliest to reduce the suffering and improve the quality of life among the elderly.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khajjayam_2017, title = {Surgical site infections in the department of general surgery and surgical gastroenterology in a teaching hospital: a prospective study}, author = {Radha Krishna Khajjayam and Sumaya Fatima and Shafia Fatima and Syed Ibad Uddin Taqui and Sara Fatima}, url = {https://ijppr.humanjournals.com/wp-content/uploads/2017/06/11.Dr_.-Radha-Krishna.-K-Sumaya-Fatima-Shafia-Fatima-Syed-Ibad-Uddin-Taqui-Dr.-Sara-Fatima.new_.pdf}, issn = {2349-7203}, year = {2017}, date = {2017-05-25}, urldate = {2017-05-25}, journal = {International Journal of Pharmacy & Pharmaceutical Research}, volume = {9}, issue = {2}, pages = {160-166}, abstract = {Background: Surgical site infections (SSI’s) are the third most commonly reported nosocomial infections which have an adverse impact on the hospital as well as on the patient. A continuous surveillance is essential to find out the incidence of SSI’s, risk factors implicated, organisms involved and their sensitivity patterns. Objectives: The aim of our study is to find out the incidence of SSI’s, risk factors implicated, organisms involved and their sensitivity patterns. Methodology: A prospective observational study was conducted at Owaisi hospital and research center, for patients admitted to the Department of General Surgery and Surgical Gastroenterology for a period of six months. The demographic data, diagnostic criteria, associated risk factors and laboratory data including Gram stain, culture and antimicrobial susceptibility of swabs from the surgical sites were collected. Results: Out of 130 patients recruited in the study, 7 patients showed evidence of surgical site infections at a rate of 5.38%. Prolonged duration of surgery and prior stenting of biliary tract showed significantly higher rate of surgical site infection compared to their counterparts. The most commonly isolated bacteria was Escherichia coli. Conclusion: The incidence of SSI was 5.38% which was comparable to that reported in literature. Escherichia coli was the most commonly isolated bacteria. History of prior stenting of biliary tract and prolonged duration of surgery stand out as major risk factors for incidence of SSI’s. Other comorbidities did not directly affect the rate of SSI in our study. }, keywords = {Deccan School of Pharmacy, General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Khan_2017c, title = {Anaesthetic management of Bochdalek hernia in a 72-year-old patient- a rare case report}, author = {Basheer Ahmed Khan and Zara Batool and Unaiza and Mohammed Sirajuddin}, url = {https://www.jebmh.com/articles/anaesthetic-management-of-bochdalek-hernia-in-a-72yearold-patient-a-rare-case-report.pdf.pdf}, doi = {10.18410/jebmh/2017/498}, issn = {2349-2562}, year = {2017}, date = {2017-05-22}, urldate = {2017-05-22}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {4}, issue = {41}, pages = {2518}, abstract = {A 72-year-old female was admitted to the hospital with the complaints of difficulty in breathing and chest discomfort after food intake since 7 months. She also complained of reflux vomiting after a regular meal for the same duration. Other complaints included weight loss, cough after taking even water and recurrent upper respiratory tract infection.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2017, title = {A study to assess the knowledge and belief of female towards breast cancer and its screening practices in Hyderabad, India}, author = {Sultan Rizwan Ahmad and Shaik Riyaz Ameer and A. Chandrasekhar}, url = {http://journal.njrcmindia.com/index.php/njrcm/issue/view/13/10}, issn = {2277-1522}, year = {2017}, date = {2017-04-24}, urldate = {2017-04-24}, journal = {National Journal of Research in Community Medicine}, volume = {6}, issue = {2}, pages = {116-119}, abstract = {Background: Cancer affects all communities world wide, approximately 14 million new cases and 8 million deaths were there in 2012. Breast cancer is by far the most common cancer among women. Most of the victim turn up for medical intervention at advanced stage when survival rate is low. Commonest reason for late reporting is lack of awareness about risk factor, symptoms and early detection methods of breast cancer. Objectives: To assess the knowledge and belief of female towards breast cancer. Methodology: A hospital based study was carried out at Deccan College of Medical sciences, Hyderabad during the period of August 2013 to October 2013. Women age 20 or more attending Obstetric and Gynecology OPD of Owaisi hospital during study period were included in study. A pretested structured questioner was used to collect the needed information from respondents. Data was entered in MS excel, and analyzed and presented by frequency table. Results: Total 179 women were participated in study. Most of them (83.2%) were aware of breast cancer and agree that risk of breast cancer increase with high fat diet, early menarche, oral contraceptive use and radiation exposure. Only 48% of participants were aware that test to detect breast cancer is available and only 20% had knowledge about breast self examination and only 4% practice it. Conclusion: It is concluded that though awareness regarding breast cancer was good but there was poor knowledge and practice about screening test.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Jaiswal_2017, title = {A study of association of fluoroquinolones in tendinitis and associated complications}, author = {Akash Jaiswal and Mazharuddin Ali Khan}, url = {https://www.jebmh.com/articles/a-study-of-association-of-fluoroquinolones-in-tendinitis-and-associated-complications.pdf.pdf}, doi = {10.18410/jebmh/2017/362}, issn = {2349-2562}, year = {2017}, date = {2017-04-17}, urldate = {2017-04-17}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {4}, issue = {31}, pages = {1855-1858}, abstract = {BACKGROUND: Fluoroquinolones are the quinolone antimicrobials, which are known to have one or more fluorine substitutions. The first generation fluoroquinolones, which was introduced in 1980s have one fluoro substitution. This was very affective in cases of gram-negative bacterias.1 In the 1990s, compounds with additional fluoro and other substitutions have been developed further extending antimicrobial activity to gram-positive cocci and also anaerobes, which also has higher metabolic stability.2,3,4 It also has a higher half-life. These are referred to as second generation fluoroquinolones. The first generation fluoroquinolone includes norfloxacin, ciprofloxacin, ofloxacin and pefloxacin. Second generation fluoroquinolone includes levofloxacin, lomefloxacin, sparfloxacin, moxifloxacin, gemifloxacin and prulifloxacin. The present topic of controversy is tendinopathy and tendon rupture induced by fluoroquinolone. There is enough data, which suggest that fluoroquinolones should be used with utmost care in population of patients. That means, not all the patients with gram-negative infections can be given this antibiotic as it has its own side effects. The first one to publish report was that of a fifty-six-year-old patient who had urinary tract infection and was treated with norfloxacin. The patient developed Achilles tendinopathy and the associated rupture was reported in New Zealand in the year 1983. Subsequently, there were many other case reports and case-controlled studies reporting similar findings. Fluoroquinolone are commonly prescribed to treat community-acquired infections involving the respiratory, urogenital and gastrointestinal tracts. Fluoroquinolone concentration is seen on a higher scale in bones and joints when compared to the serum levels. So, it is ideal to treat the bones and joint infections. The cartilage infections is also treated with fluoroquinolone. Achilles tendinitis or rupture is among the most serious side effects associated with fluoroquinolone. This study puts in a sincere effort to understand in depth the tendinitis and rupture complications caused by the drugs, which belong to fluoroquinolones. This study is intended to help the general practitioners and the practicing orthopaedicians to know the depth of the disease and to attend the primary cause of the tendinitis and associated rupture secondary to the use of fluoroquinolones. MATERIALS AND METHODS: Forty patients were selected who attended the Department of Orthopaedics and complained of tendon pain or tendon rupture. The present study was done in the Department of Orthopaedics, Deccan Medical College, at Hyderabad. Detailed history was taken and the patients were divided into 4 age groups. 20-40 years were taken into group-1; 40-60 years were taken into group-2; 60-80 years were taken into group-3 and >80 years old were taken into group-4. Past history was taken in detail and use of fluoroquinolone drugs were asked. Gender-based statistical analysis was not done as female patients were very low in number. All statistical analysis was done using latest SPSS (2015) Software, California. RESULTS: In the present study, the mean age of the population that was considered for the study was 61.11 years and the standard deviation was 21.739 years. The study group was divided into four groups. 20-40 years were taken into group-1; 40-60 years were taken into group-2; 60-80 years were taken into group-3 and >80 years old were taken into group-4. Group-1 consisted of 3 patients, group-2 consisted of 4 patients, group-3 consisted of the highest number of patients and consisted of 26 patients and the group-4 consisted of 7 patients. Out of the present patients, 2 patients who belonged to group-2 and group-3 complained of tendon rupture and thus there was a strong association of the tendon ruptures with use of fluoroquinolone drugs. Out of the patients, 4 patients who belonged to group-3 and one patient who belonged to group-4 had tendinitis. Thus, there was a strong association of the tendon ruptures with use of fluoroquinolone drugs. CONCLUSION: There is a positive significant relation between the tendinitis and tendon rupture complications associated with the use of fluoroquinolones. The study successfully shows the association. In a country like ours where these fluoroquinolone drugs are used very commonly has to check its utilisation in a proper way.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Kema_2017, title = {Protective effects of diallyl sulfide against ethanol-induced injury in rat adipose tissue and primary human adipocytes}, author = {Venkata Harini Kema and Imran Khan and Reshma Jamal and Sandeep Kumar Vishwakarma and Chandrakala Lakkireddy and Kirti Parwani and Farhin Patel and Dhara Patel and Aleem Ahmed Khan and Palash Mandal}, url = {https://onlinelibrary.wiley.com/doi/10.1111/acer.13398}, doi = {10.1111/acer.13398}, issn = {2993-7175}, year = {2017}, date = {2017-04-17}, urldate = {2017-05-01}, journal = {Alcoholism: Clinical and Experimental Research}, volume = {41}, issue = {6}, pages = {1078-1092}, publisher = {Wiley}, abstract = {Background: Alcohol consumption is the fourth leading cause of death and disability worldwide. Several cellular pathways contribute to alcohol-mediated tissue injury. Adipose tissue apart from functioning as an endocrine organ secretes several hormones and cytokines known as adipokines that are known to play a significant role in alcohol-induced tissue damage. This study was designed to test the efficacy of diallyl sulfide (DAS) in regulating the alcohol-induced outcomes on adipose tissue. Methods: Male Wistar rats were fed with 36% Lieber–DeCarli liquid diet containing ethanol (EtOH) for 4 weeks. Control rats were pair-fed with isocaloric diet containing maltodextrin instead of EtOH. During the last week of feeding protocol, the EtOH-fed rat group was given 200 mg/kg body weight of DAS through diet. We also studied DAS effect on isolated human primary adipocytes. Viability of human primary adipocytes on DAS treatment was assessed by MTT assay. Malondialdehyde (MDA), a marker of oxidative stress, was measured by HPLC and the thiobarbituric acid method. Expression of inflammatory genes and lipogenic genes was studied by qRT-PCR and Western blotting. Serum inflammatory gene expression was studied by ELISA. Results: Our study results showed that DAS could alleviate EtOH-induced expression levels of proinflammatory and endoplasmic reticulum (ER) stress genes and improve adipose tissue mass and adipocyte morphology in male Wistar rats fed Lieber–DeCarli diet containing 6% EtOH. Further, we showed that DAS reduced the expression of lipogenic genes and improved lipid accumulation and adipocyte mass in human primary adipocytes treated with EtOH. Subsequently, we also showed that oxidative stress, as measured by the changes in MDA levels, was reduced in both male Wistar rats and human primary adipocytes treated with EtOH plus DAS. Conclusions: Our study results prove that DAS is effective in ameliorating EtOH-induced damage to adipose tissue as evidenced by the reduction brought about by DAS in oxidative stress, ER stress, and proinflammatory gene expression levels. DAS treatment also regulated lipogenic gene expression levels, thereby reducing free fatty acid release. In conclusion, this study has clinical implications with respect to alcohol-induced adipose tissue injury among alcohol users.}, key = {pmid28414868}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Farheen_2017, title = {Hematological parameters are acutely effected by cement dust exposure in construction workers}, author = {Ayesha Farheen and Mohammed Abdul Hannan Hazari and Farisa Khatoon and Fareen Sultana and Sanam Maria Qudsiya}, url = {https://amphysiol.com/index.php/amp/article/view/v1i1.263312}, doi = {10.23921/amp.2017v1i1.263312}, issn = {2456-8422}, year = {2017}, date = {2017-04-13}, urldate = {2017-04-13}, journal = {Annals of Medical Physiology}, volume = {1}, issue = {1}, pages = {31-35}, abstract = {Cement dust poses an occupational hazard causing respiratory (owing to its inhalation), dermatological, ocular and hematological problems. The purpose of the current study was to evaluate the effect of occupational exposure of cement dust on hematological parameters in construction workers. Apparently healthy sixty five (65) adult male construction workers aged 25-50 years participated in this study. Three (3.0) ml venous blood samples were collected from each participant for hematological analysis at two different time points, one at 8 AM and second at 4 PM at the end of work shift. Differences in means and test of significance were calculated using paired Student’s t-test. The results revealed that post shift samples showed statistically significant increase (p<0.05) in mean total leukocyte count (TLC), lymphocyte %, monocyte % and eosinophil % and statistically significant decrease (p<0.05) in mean hemoglobin, red blood cell (RBC) count, packed cell volume (PCV) and platelet count. The present study confirms that hematological parameters are significantly effected in construction workers which may be attributed to the work atmosphere predominated with cement dust.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2017b, title = {Effect of intrathecal ketamine as an adjuvant on the dose of intrathecal bupivacaine}, author = {Vijaya Rekha Koti and Saratbabu Chevuri and Mohammed Umer Majid and Syeda Huma Gulbadeen}, url = {https://www.medpulse.in/Anesthsiology/Article/Volume2Issue1/Anes_2_1_3.pdf}, doi = {10.26611/1015213}, issn = {2579-0900}, year = {2017}, date = {2017-04-12}, urldate = {2017-04-12}, journal = {MedPulse International Journal of Anesthesiology}, volume = {2}, issue = {1}, pages = {12-16}, abstract = {Background: A randomized control study was done to evlauate the effect of ketamine on the dose of bupivacaine when added as an adjuvant to intrathecal bupivacaine. Materials and Methods: 90 patients were divided randomly into 3 groups of 30 each. Group - 1 received 0.5% heavy Bupivacaine 3cc, Group 2 received 0.5% heavy Bupivacaine +preservative free ketamine 25mg. Group 3 received 0.5% heavy Bupivacaine 2.5cc + 0.5cc normalsaline. All patients after thorough checkup, after obtaining informed consent, recording basal parameters were shifted to O.T. Spinal anaesthesia was given in sitting position in L3-L4 space with 25G Quincke spinal needle, group specific drug was injected and immediately made supine. Monitoring was done by another person. Time of onset of T12 blockade, height of blockade, onset and duration of motor and sesory blockade and haemodynamic parameters were noted down. Observations and Results: Onset of sensory block, motor block were fast with Gr 2 then Gr 1 lastly with Gr3. Intensity of motor block (assessed by modified Bromage scale) is good with Gr1, then with Gr 2 and last with Gr 3. Haemodynamics are better maintained with Gr 2 than Gr 1. Recoveryfrom block (2 segment regression) was early in Gr 3 then Gr 2 last with Gr 1 motor block. Conclusion: When preservative free ketamine 25mg is added to bupivacaine 2.5 cc (0.5% heavy) produces early and good analgesia, adequate relaxation for infraumbilical surgeries compared to 2.5cc of Bupivacaine alone and better maintained haemodynamics and early recovery from block than 3cc of Buppivacaine so that dose of intrathecal dose of Bupivacaine can be reduced. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Qudsiya_2017, title = {Study of intraocular pressure among individuals working on computer screens for long hours}, author = {Sanam Maria Qudsiya and Farisa Khatoon and Aftab Abdul Khader and Mohammed Asghar Ali and Mohammed Abdul Hannan Hazari and Fareen Sultana and Ayesha Farheen}, url = {https://amphysiol.com/index.php/amp/article/view/v1i1.263328}, doi = {10.23921/amp.2017v1i1.263328}, issn = {2456-8422}, year = {2017}, date = {2017-04-11}, urldate = {2017-04-11}, journal = {Annals of Medical Physiology}, volume = {1}, issue = {1}, pages = {22-25}, publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House}, abstract = {In today’s world computers are ubiquitous and found in different forms which can effect intraocular pressure (IOP). Present study was undertaken to find out effect of day-to-day exposure to computer screen on IOP in normal individuals. 70 individuals (who met the screening conditions and devoid of obvious ocular pathology and systemic diseases) had their IOP’s checked before and 4 hour after computer session on same day, all working in general day shift, involving reading English printed material. The results showed significant (p<0.005) increase with IOP values before exposure being 17.89±3.25 and 16.99±2.84 and after exposure being 19.67±3.4 and 18.70±2.4 in left and right eye respectively. Increase in IOP was noted in 70% and 67% individuals in left and right eye. Differences in IOP of right and left eye may be due to dominance of eye or direction of script from left to right.}, keywords = {Ophthalmology, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2017, title = {Dexmedetomidine an adjuvant in anesthesia for functional endoscopic sinus surgery (FESS)}, author = {Vijaya Rekha Koti and Saratbabu Chevuri and Syed Abdul Wasiq and Bashirunnisa}, url = {https://www.rfppl.co.in/subscription/upload_pdf/Vijayarekha%20Koti_5128.pdf}, doi = {10.21088/ijaa.2349.8471.4217.28}, issn = {2349-8471}, year = {2017}, date = {2017-04-07}, urldate = {2017-04-07}, journal = {Indian Journal of Anaesthesia and Analgesia}, volume = {4}, issue = {2}, pages = {532-536}, abstract = {Introduction: Dexmedetomidine can provide controlled hypotension, analgesia, and sedation. The present study aimed to evaluate advantages of dexmedetomidine as an adjuvant in anesthesia for FESS(Functional Endoscopic Sinus Surgery). Materials and Methods: Study was conducted in 50 patients form April -2015 to March -2016 after obtaining approval from ethical committee and informed consent from the patients. who were ASA grade I/II, aged between 18-55years scheduled for FESS. Patients were randomly allocated into two groups of Group D(n=25)which received injection Dexmeditomidine as loading dose of 1mcg/kg intravenously followed by maintenance infusion of 0.6mcg/kg intravenously and Group NS(n=25) received normal saline in similar volume. Results: The baseline mean systolic blood pressure was lower during surgery in patients of group D, but not statistically significant . At the end of surgery and after recovery, blood pressure is significantly lower in group D (114± 11 vs. 131 ± 9 mmHg; P < 0.05). Baseline values of the mean heart rate intraoperatively was significantly reduced compared with the baseline value in group D (P < 0.05), After extubation, the heart rate was found to be higher in patients of the Group-NS (98 ± 4 vs. 86 ± 3 beats/minutes). Blood losses were lower in group D as compared to group NS (p= 0.03).The Visual Analogue Scale (VAS) scores in the immediate postoperative periods were also significantly lower in the group D (p =0.03). The only side effect noted was bradycardia in 3 patients in group D. Isoflurane requirement was also reduced in the maintenance of anaesthesia. Conclusion: Dexmedetomidine as an adjuvant for hypotensive anaesthesia is effective and decreases bleeding thus providing relatively bloodless field during FESS. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2017, title = {Incidence of acute renal failure in birth asphyxia and its correlation with hypoxic ischemic encephalopathy (HIE)}, author = {B. Sugunakar Reddy and Uppin Narayan Reddy and Jakkampudi Nagasravani and Mohd. Nasir Mohiuddin}, url = {https://www.ijmrhs.com/medical-research/incidence-of-acute-renal-failure-in-birth-asphyxia-and-its-correlation-with-hypoxic-ischemic-encephalopathy-hie.pdf}, issn = {2319-5886}, year = {2017}, date = {2017-04-01}, urldate = {2017-04-01}, journal = {International Journal of Medical Research & Health Sciences}, volume = {6}, issue = {4}, pages = {80-91}, abstract = {Introduction: Perinatal asphyxia is an essential reason for neonatal mortality and neurological morbidity. The general rate of this condition is assessed to be between 1 to 10 for every 1000 live births and is affected by the birth weight and gestational age of the infant furthermore by the neighbourhood accessibility of therapeutic assets. Methods: The underlying administration of every single such neonate comprised of putting the child under a servo-controlled radiant warmer and nursing them in the thermo-neutral range of temperature. About 41 cases accomplished for early identification of confusions and difficulties and their convenient administration. Following 72 h of birth and before 96 h of birth in the wake of getting educated composed assent from the guardians, under aseptic safety measures 3 ml blood was drawn and was assessed for blood urea (Berthelot strategy), serum creatinine (Jaffe’s test), serum electrolytes (Calorimetric technique) and urine yield was observed by applying plastic accumulation pack (minicom) and clinical state of the child was checked. Results: A sum of 1285 neonates were conceded in NICU for different issues, among them an aggregate of 90 neonates were conceded for perinatal asphyxia. A sum of 75 cases and 50 controls were chosen. The accompanying tables and figures represent the outcomes in subtle element. The outcomes got were examine blood urea and serum creatinine levels were essentially lifted in cases with renal disappointment, when contrasted with controls (P=0.001). Nevertheless, there was no distinction in electrolyte levels in both the gatherings. Conclusion: The most common perinatal danger component was MSAF (40%). In our study the commonest type of ARF in every one of the three phases of HIE was non-oliguric sort. The frequency of inherent renal disappointment in our study was 9.4%. Checking of blood urea, serum creatinine and urine yield helps in the early finding and administration of renal disappointment. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Sultana_2017, title = {Effect of stress on erythryocytic osmotic fragility in healthy individuals}, author = {Fareen Sultana and Farisa Khatoon and Mohammed Abdul Hannan Hazari and Sanam Maria Qudsiya and Ayesha Farheen}, url = {https://www.ijcap.org/article-details/3634}, doi = {10.18231/2394-2126.2017.0008}, issn = {2394-2118}, year = {2017}, date = {2017-03-31}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {4}, issue = {1}, pages = {30-33}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Background: The aim of the study was to examine relationship between severity of stress and onset/completion of erythrocyte haemolysis in normal healthy individuals. Materials and Methods: The study was conducted in Physiology department, Deccan College of Medical Sciences, Hyderabad, after approval from the Institutional Review Board. The study included 50 healthy individuals of both the sexes aged between 20 to 50 years. Individuals working for minimum 8 to 10 hours a day were included and individuals suffering from hypertension, obesity, diabetes mellitus, musculo-skeletal disorders, sickle cell disease and goitre were excluded. Osmotic fragility was determined by collecting 2ml of blood from each individual and stored in EDTA tubes. A drop of blood was added to saline solutions of different tonicity arranged in 12 test tubes. The test tubes were seen for onset and end of hemolysis after an hour. Stress was measured by Cohen’s perceived stress questionnaire and individual were divided into 3 groups viz. low, moderate and high stress categories as per their scores. Results: Findings were analysed by student’s t-test and completion of hemolysis was earlier in severe stress group compared to mild and moderate. There is no significant difference between males and females regarding point of onset of hemolysis (p=0.41) and end of hemolysis (p=0.37). Stress increases fragility and it was found that RBC fragility was significantly related to severity of stress. Fragility is not affected by gender. Conclusion: RBC fragility was significantly related to severity of stress and it was found that fragility is not affected by gender.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2017, title = {Central blood pressure parameters in young adults with and without parental history of hypertension}, author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Hamza Zoeb Hussain and Farah Fatima and Nudrath Kahkashan}, url = {https://amphysiol.com/index.php/amp/article/view/v1i1.262334}, doi = {10.23921/amp.2017v1i1.262334}, issn = {2456-8422}, year = {2017}, date = {2017-03-31}, urldate = {2017-03-31}, journal = {Annals of Medical Physiology}, volume = {1}, issue = {1}, pages = {16-21}, abstract = {Hypertension is increasingly being found in children and adolescence. The purpose of this study was to find out differences in the central arterial (aortic) blood pressure parameters in young adults with hypertensive and normotensive parents. 109 healthy volunteers between the ages of 17 and 25 years were enrolled for the study after taking consent. Brachial artery pressures and aortic parameters were recorded using PeriScope™ which determines aortic parameters and functional vascular age non-invasively based on oscillometric method. The results of this study showed no statistically significant difference between offspring of hypertensive parents and offspring of normotensive parents.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Chevuri_2017, title = {The impact of verapamil addition to ketamine and lidocaine intravenous regional anesthesia: a randomized controlled study}, author = {Saratbabu Chevuri and Vijaya Rekha Koti }, url = {https://www.iaimjournal.com/storage/2017/04/iaim_2017_0404_06.pdf}, issn = {2394-0026}, year = {2017}, date = {2017-03-31}, urldate = {2017-03-31}, journal = {International Archives of Integrated Medicine}, volume = {4}, issue = {4}, pages = {27-34}, abstract = {Background: The use of adjuncts along with Lidocaine during intravenous regional anesthesia (IVRA) decreases tourniquet pain and prolongs post-operative analgesia. Addition of ketamine reduces the time for onset of block, delays the onset of tourniquet pain and reduces postoperative analgesic requirement. Verapamil potentiates the effect of neuromuscular blocking agents. This study was designed to evaluate the effect of adding Verapamil (2.5 mg) to Lidocaine plus Ketamine (0.5mg/kg) in comparison with lidocaine plus ketamine IVRA. Materials and methods: Hundred and twenty patients, aged 18–50 years, ASA physical status I and II undergoing elective hand or forearm surgery under Bier’s Block lasting one to one and half hours were included in this double-blinded, randomized and controlled study. Patients were divided into two groups of 60 patients each. Group- I (control group) received 40 ml of 0.5% Lidocaine plus ketamine (0.5 mg/kg) and Group- II received an addition of 2.5 mg of verapamil IVRA. Sensory and motor block onset and recovery time were noted. After the tourniquet deflation: pain, sedation values, time to first analgesic requirement and side effects were evaluated over a period of 12 hours. Results: Significant postoperative hemodynamic changes, sedation score, pain score and delayed first request for analgesia was observed in-group II when compared to group I. Sensory and motor block characteristics were significant in-group II as against group I. The side effect profile of verapamil (2.5mg) was minimal with a few episodes of hypotension and bradycardia, which were clinically managed by ephedrine and atropine respectively. Conclusions: Adding verapamil 2.5 mg to Lidocaine plus ketamine (0.5 mg/kg) for IVRA proved to be an effective and safe adjuvant for acute pain after surgery.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2017b, title = {A retrospective study on prescribing pattern of drugs in female infertility at a tertiary care center in South India}, author = {Shaheda Siddiqui and Fatima Tahniyath and Ayesha Butool and Kauser Fatima and Raga Reddy and Roya Rozati}, url = {https://zenodo.org/record/2384633}, doi = {10.5281/zenodo.2384633}, issn = {2231-6876}, year = {2017}, date = {2017-03-31}, urldate = {2017-03-31}, journal = {Indo American Journal of Pharmaceutical Research}, volume = {7}, issue = {3}, pages = {7861-7868}, abstract = {ntroduction: A disease of the reproductive system defined by the failure to achieve a clinical pregnancy after12 months or more of regular unprotected sexual intercourse. The demand for overcoming infertility is increasing year by year. Hence there is a quantum jump in the technology used in the diagnosis and therapy of infertility. Aim/ Objective: To observe the rationality among the prescriptions with principle aim to study the efficacy, tolerability, safety and cost-effectiveness of the drugs used in infertility cases and to evaluate the prescribing pattern and criteria for selection of drugs for infertility. Methodology: A retrospective, observational study was conducted in the department of Obstetrics and Gynecology at Owaisi Hospital and Research Centre, Hyderabad, India. The duration of the study was 15 month period from September 2015 to Dec 2016 on 300 consenting female infertility patients. Results: In our study 43% of patients belonged to age group 26-30. 45% were newly diagnosed patients,65.3 % of patients had primary infertility and whereas 34.6% had secondary infertility. Menstrual irregularity were the most common cause of infertility (36%). The patients were treated with drug alone depending on their age and cause of infertility. Clomiphene Citrate (12.76%) was the most common drug prescribed for ovulation induction.55.3 % of patients conceived during our study, women who failed to achieve pregnancy needed Assisted Reproductive Technology. The PDD and DDD was calculated to achieve rationality of prescriptions. Conclusion: Infertility is a critical component of reproductive health which is a global public health challenge. The use of pharmacoepidemological data can help in designing, delivering and evaluating many interventions to improve the use of fertility drugs and outcome of patients as Infertility is a global health issue.}, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Haneef_2017, title = {A retrospective study of patient compliance to narrow band ultraviolet B phototherapy in vitiligo patients}, author = {Nayeem Sadath Haneef and B. Y. Praveen Kumar and Nikhat Fatima}, url = {https://jemds.com/data_pdf/Nayeem%202.pdf}, doi = {10.14260/Jemds/2017/366}, issn = {2278-4748}, year = {2017}, date = {2017-03-13}, urldate = {2017-03-13}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {6}, issue = {21}, pages = {1662-1666}, abstract = {BACKGROUND: Narrow band ultraviolet B (NBUVB) phototherapy is a well-established, effective and relatively safe treatment modality for treatment of vitiligo. An essential prerequisite for efficacy of NBUVB phototherapy is good compliance by patients. There is a paucity of literature on patient compliance to requisite number of sessions of NBUVB therapy in patients of vitiligo, where phototherapy is required for a prolonged duration. MATERIALS AND METHODS: A 2-year retrospective analytical study was conducted to analyse patient compliance to NBUVB phototherapy in patients of vitiligo. All the patients were advised to visit the hospital for phototherapy thrice a week. Thus, in the initial 3 months (13 weeks), prescribed number of phototherapy sessions amounts to 39. Based on the actual number of phototherapy sessions completed by patients during this initial 3 months period, patient compliance to NBUVB therapy was graded as excellent (completion of > 75% of prescribed number of sessions), good (completion of >50-75 % of prescribed number of sessions), poor (completion of >25-50% of prescribed number of sessions) and very poor (completion of < 25 % of prescribed number of sessions). RESULTS: During the 2-year study period, 33 patients of vitiligo were prescribed narrow band UVB phototherapy, of which 11 patients dropped out after less than 8 sessions of phototherapy. Of the remaining 22 patients, only 5 patients (22.72%) had excellent compliance (completed > 75% of prescribed number of sessions), 3 patients (13.63%) had good compliance (>50-75% of prescribed number of sessions), 12 patients (54.54%) had poor compliance (>25-50% of prescribed number of sessions) and 2 patients (9.09%) had very poor compliance (<25% of prescribed number of sessions). Most common reasons for poor compliance were difficulty in adjusting school/college timings (42.85%) and distance/transport problems (35.71%). CONCLUSION: Poor patient compliance to narrow band UVB phototherapy, as observed in majority of patients in the present study, may be due to several reasons. Poor compliance may adversely impact the efficacy of this excellent therapeutic modality in patients of vitiligo. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Jangda_2017, title = {Body dysmorphic disorder: a serious concern for our young generation}, author = {Ayesha Altaf Jangda and Mohd Faisaluddin and Muhammad Ahmed Jangda and Muhammad Asim Khan and Ayyaz Alam Sultan and Syed Raza Shah}, url = {https://www.sciencedirect.com/science/article/abs/pii/S1876201816302015?via%3Dihub8}, doi = {10.1016/j.ajp.2017.03.008}, issn = {1876-2018}, year = {2017}, date = {2017-03-10}, urldate = {2017-08-01}, journal = {Asian Journal of Psychiatry}, volume = {28}, pages = {3}, publisher = {Elsevier BV}, key = {pmid28784390}, keywords = {No Department}, pubstate = {published}, tppubtype = {article} } @article{Haneef_2017b, title = {A retrospective study of duration of phase 1 of dexamethasone-cyclophosphamide pulse therapy in pemphigus patients}, author = {Nayeem Sadath Haneef and Fatima Razvi and B. Y. Praveen Kumar and Nikhat Fatima}, url = {https://jemds.com/data_pdf/Nayeem%201--.pdf}, doi = {10.14260/Jemds/2017/346}, issn = {2278-4748}, year = {2017}, date = {2017-03-09}, urldate = {2017-03-09}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {6}, issue = {20}, pages = {1575-1577}, abstract = {BACKGROUND: Dexamethasone-Cyclophosphamide Pulse (DCP) therapy, consisting of 4 phases is very effective, safe and inexpensive treatment modality for pemphigus patients. There are very few studies on duration of phase I in pemphigus, which affects the total duration of DCP therapy. MATERIALS AND METHODS: A 2-year retrospective analytical study was conducted to calculate duration of phase I of DCP therapy in 65 immuno-histopathologically confirmed patients of pemphigus. RESULTS: Duration of phase I was less than 6 months in 31 patients (47.69%). It was 7 - 12 months in 27 patients (41.53%). Just 7 patients (10.76%) had to take phase I DCP for 12 - 18 months. CONCLUSION: Duration of phase I of DCP was less than 12 months in majority of the patients (89.23%). This duration was less in 6 months in close to 50% of the patients.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Mirza_2017, title = {A study to evaluate the role of intravenous immunoglobulin (IVIG) as an adjuvant in the management of neonatal sepsis in preterm babies}, author = {Awais Mirza and Uppin Narayan Reddy and Altaf Naseem and Sumsam Ali Khurram}, url = {https://www.ijmrhs.com/medical-research/a-study-to-evaluate-the-role-of-intravenous-immunoglobulin-ivig-as-an-adjuvant-in-the-management-of-neonatal-sepsis-in-p.pdf}, issn = {2319-5886}, year = {2017}, date = {2017-03-01}, urldate = {2017-03-01}, journal = {International Journal of Medical Research & Health Sciences}, volume = {6}, issue = {3}, pages = {107-113}, abstract = {Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune deficient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at full term. Furthermore, exceptionally preterm newborn children have lessened supplement components, polymorphonuclear chemotaxis and are obligated to debilitate their capacity pools. Aims and Objectives: This planned study has been attempted with the accompanying targets, to concentrate on the administration of IVIG in addition with antibiotics to improves the therapeutic consequence of sepsis in preterm neonates. Materials and Methods: Sixty preterm neonates with sepsis were randomly assigned into study and control groups at a tertiary level neonatal intensive care unit, Princess Esra Hospital and Owaisi Hospital & Research Centre, Deccan College of Medical Sciences, Hyderabad, Telangana, India. Study-group was given IVIG in addition to standard treatment. Results: Total 60 patients were enrolled, 30 in study and 30 in control group. There were no gender differences (male 50%, female 50%) of neonates enrolled, which is also evident in the study (males 47.7%, females 52.3%) and control group (males 52.3%, females 47.7%). Conclusion: Low levels of immunity in preterm neonates results in increased morbidity and mortality in severe infection. Use of IVIG along with the antibiotics and other supportive therapy can improve the outcome. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Breik_2017, title = {Carina at the carina: spirometry leading to the diagnosis of an unusual foreign body within the tracheobronchial tree}, author = {Fahad Abdullah Bin Breik and Ghouse Ahmed Khan and Sandeep Saboo and Mohammed Raheem Hussain and Ashfaq Hasan}, url = {https://www.respircase.com/jvi.aspx?un=RCR-61587&volume=6&issue=1}, doi = {10.5505/respircase.2017.61587}, issn = {2051-3380}, year = {2017}, date = {2017-02-28}, urldate = {2017-02-28}, journal = {Respiratory Case Reports}, volume = {6}, issue = {1}, pages = {1-4}, abstract = {Foreign bodies in the lung can be difficult to diagnose. They may result in unusual symptoms leading to confusion about the diagnosis. Spirometry can sometimes provide a clue to a mainstem obstruction, although it may be compromised by artifacts. Herein, we present a case of an unusual foreign body within the tracheobronchial tree, for which spirometry provided the indication for bronchoscopy.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khan_2017b, title = {Comparative study of pressor responses after tracheal extubation and LMA (laryngeal mask airway) removal in controlled hypertensive patients: a randomised clinical trial}, author = {Basheer Ahmed Khan and Mohammed Sirajuddin and Zara Batool and Unaiza}, url = {https://www.ijhsr.org/IJHSR_Vol.7_Issue.3_March2017/3.pdf}, issn = {2249-9571}, year = {2017}, date = {2017-02-11}, urldate = {2017-02-11}, journal = {International Journal of Health Sciences and Research}, volume = {7}, issue = {3}, pages = {14-21}, abstract = {Background and objectives: Airway management using endotracheal intubation and laryngeal mask airway (LMA) are known to induce hemodynamic changes. The predominant response is tachycardia and systemic hypertension. The present study was undertaken to compare the hemodynamic responses after tracheal extubation and LMA removal in controlled hypertensive patients. Methodology: The study was conducted on 70 patients in age group of 35-65 yrs, ASA Grade II scheduled for elective surgical procedures. Patients were allocated in randomized manner in two groups, one undergoing endotracheal tube intubation (Group T) and other undergoing laryngeal mask airway insertion (Group L). Each group had 35 patients. The hemodynamic data included pulse rate and blood pressure that were recorded at time intervals: baseline before intubation, at 1, 2, 3, 5 and 10 min after extubation or LMA removal. Rate pressure product was calculated. Results: Extubation caused significant increase in mean pulse rate in Group T, which failed to reach baseline level after 10 minutes. LMA removal in Group L was associated with significant increase in mean pulse rate however it returned back to baseline at 5minutes after removal. Significant rise in MAP after extubation and LMA removal was observed in Group T and L, it did return to baseline values after 5 min in Group L and no such effect observed even after 10 min in Group T. Rise in mean pulse rate and mean arterial pressure was significantly higher when compared between group T and group L. Similar observations were made for rate pressure product in Group L and T respectively. Interpretation and conclusion: Both endotracheal extubation and laryngeal mask airway removal were associated with a statistically significant rise in pulse rate, rate pressure product and MAP. The rise was significantly higher in Group T as compared to Group L. LMA removal was found to be accompanied with lesser pressor response as compared to endotracheal tube extubation in controlled hypertensive patients. Use of Laryngeal mask airway is quite advantageous and hence is desirable in hypertensive patients.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Afroz_2017, title = {A comprehensive gene expression meta-analysis identifies novel immune signatures in rheumatoid arthritis patients}, author = {Sumbul Afroz and Jeevan Giddaluru and Sandeep Vishwakarma and Saima Naz and Aleem Ahmed Khan and Nooruddin Khan}, url = {https://www.frontiersin.org/articles/10.3389/fimmu.2017.00074/full}, doi = {10.3389/fimmu.2017.00074}, issn = {1664-3224}, year = {2017}, date = {2017-02-02}, urldate = {2017-02-01}, journal = {Frontiers in Immunology}, volume = {8}, pages = {1-12}, publisher = {Frontiers Media SA}, abstract = {Rheumatoid arthritis (RA), a symmetric polyarticular arthritis, has long been feared as one of the most disabling forms of arthritis. Identification of gene signatures associated with RA onset and progression would lead toward development of novel diagnostics and therapeutic interventions. This study was undertaken to identify unique gene signatures of RA patients through large-scale meta-profiling of a diverse collection of gene expression data sets. We carried out a meta-analysis of 8 publicly available RA patients’ (107 RA patients and 76 healthy controls) gene expression data sets and further validated a few meta-signatures in RA patients through quantitative real-time PCR (RT-qPCR). We identified a robust meta-profile comprising 33 differentially expressed genes, which were consistently and significantly expressed across all the data sets. Our meta-analysis unearthed upregulation of a few novel gene signatures including PLCG2, HLA-DOB, HLA-F, EIF4E2, and CYFIP2, which were validated in peripheral blood mononuclear cell samples of RA patients. Further, functional and pathway enrichment analysis reveals perturbation of several meta-genes involved in signaling pathways pertaining to inflammation, antigen presentation, hypoxia, and apoptosis during RA. Additionally, PLCG2 (phospholipase Cγ2) popped out as a novel meta-gene involved in most of the pathways relevant to RA including inflammasome activation, platelet aggregation, and activation, thereby suggesting PLCG2 as a potential therapeutic target for controlling excessive inflammation during RA. In conclusion, these findings highlight the utility of meta-analysis approach in identifying novel gene signatures that might provide mechanistic insights into disease onset, progression and possibly lead toward the development of better diagnostic and therapeutic interventions against RA.}, key = {pmid28210261}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2017b, title = {Noughts and crosses: the uncertain future of TB control in India}, author = {Ashfaq Hasan}, url = {https://jmas.in/fulltext/154-1485322681.pdf?1676958653}, doi = {10.5455/jmas.256739 }, issn = {2231-1696}, year = {2017}, date = {2017-01-31}, urldate = {2017-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {7}, issue = {1}, pages = {1-2}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2017, title = {Is obstructive sleep apnea more prevalent than central sleep apnea in patients with systolic heart failure? A retrospective study}, author = {Ashfaq Hasan and Nazia Uzma and Fahad Abdullah Bin Breik and Mohammed Abdul Hannan Hazari and C. Narasimhan and L. Rao}, url = {https://www.hilarispublisher.com/archive/jcrdc-volume-3-issue-1-year-2017.html}, doi = {10.4172/2472-1247.1000126}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, journal = {Journal of Clinical Respiratory Diseases and Care}, volume = {03}, issue = {01}, pages = {126}, publisher = {OMICS Publishing Group}, abstract = {Central sleep apnea (CSA) rather than obstructive sleep apnea (OSA) is widely believed to be the dominant form of sleep apnea (SA) in patients with heart failure (HF). Hitherto, no study has characterized sleep disordered breathing (SDB) in Indian subjects with heart failure and evaluated its impact on severity of HF, which this study attempts to do. A retrospective data-analysis was done in 65 consecutive patients with stable mild-to-moderate HF referred for evaluation on the basis of fatigue and excessive daytime somnolence (EDS) regarded by the institute’s cardiologists. Patients with ejection fraction (EF) <55% or LV fractional shortening of 28% were included in the study. PSG was scored according to current AASM recommendations. Based on the Apnea-Hypopnea Index (AHI), OSA was classified as mild (AHI:5-15), moderate (AHI: 15-30) and severe (AHI: >30). HF was arbitrarily classified as mild (EF:<35%) moderate (EF:35-45%) and severe (EF:45-55%). OSA emerged as the exclusive form of SA (95.4%; n=65) and was more severe in males. Patients with more severe HF tended to be less obese, and interestingly to have less severe OSA. In contrast to Western literature, OSA seems to be by far the most prevalent form of sleep apnea in Indian subjects with HF. HF mortality is known to be high in underweight individuals yet, persons with severe HF are often less obese and partly by reason of a lower BMI, appear to be relatively protected against severe OSA and severe nocturnal hypoxemia. This study thus raises important and intriguing questions which merit further enquiry.}, keywords = {Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Abubaker_2017, title = {Teneligliptin in management of diabetic kidney disease: a review of place in therapy}, author = {Mohammed Abubaker and Preetesh Mishra and Onkar C. Swami}, url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2017&volume=11&issue=1&page=OE05&issn=0973-709x&id=9228}, doi = {10.7860/jcdr/2017/25060.9228}, issn = {0973-709X}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {11}, issue = {1}, pages = {OE05-OE09}, publisher = {JCDR Research and Publications}, abstract = {Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing dialysis due to kidney failure. Lifestyle modifications; cessation of smoking, optimum control of blood glucose, blood pressure and lipids are required to reduce the progression of Diabetic Kidney Disease (DKD). Presently, Dipeptidyl peptidase-4 (DPP-4) inhibitors are preferred in the management of T2DM due to their established efficacy; favorable tolerability including, low risk of hypoglycaemia; weight neutrality and convenient once-a-day dosage. Present evidence suggests that linagliptin and teneligliptin can be used safely without dose adjustments in patients with T2DM with renal impairment, including End Stage Renal Disease (ESRD). There is a limited data about teneligliptin particularly in T2DM patients with renal impairment. The objective of this review is to evaluate efficacy and safety of teneligliptin in T2DM patients with renal impairment, in order to assess the current place in therapy and future prospects of teneligliptin. Reported evidence suggests that teneligliptin has consistent pharmacokinetic in mild, moderate, severe or ESRD, without any need for dose adjustments. Limited data from small sample studies of teneligliptin in DKD patients reported significant improvements in glycaemic parameters. Additionally, there is an improvement in kidney parameters like glycated albumin, urinary albumin and eGFR. There is an evidence of reduction in biomarkers of kidney impairment like P-selectin (sP-selectin), Platelet-Derived Microparticles (PDMPs) and Plasminogen Activator Inhibitor 1 (PAI-1). Clinical significance of these will be known in near future. Thus, teneligliptin has an important place of therapy in the management of T2DM with renal impairment.}, key = {pmid28273997}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2017, title = {Abdominal plain radiograph in neonatal intestinal obstruction}, author = {G. Raghavendra Prasad and Amtul Aziz}, url = {https://www.jneonatalsurg.com/ojs/index.php/jns/article/view/469/pdf3}, doi = {10.21699/jns.v6i1.483}, issn = {2226-0439}, year = {2017}, date = {2017-01-01}, urldate = {2016-12-01}, journal = {Journal of Neonatal Surgery}, volume = {6}, issue = {1}, pages = {1-6}, publisher = {Journal of Neonatal Surgery}, abstract = {A comprehensive all-inclusive resource on plain radiograph in neonatal intestinal obstruction is presented. This is an attempt to develop a protocol and to regain expertise in evaluating a plain radiograph that most often yields more than enough clues to diagnose and to decide a plan of action.}, key = {pmid28083492}, keywords = {General Surgery, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @inbook{Khan_2017d, title = {Repopulation of cirrhotic liver by hepatic stem/progenitor cells}, author = {Aleem Ahmed Khan and Sandeep Kumar Vishwakarma and Avinash Bardia and Md. Aejaz Habeeb and M. Dhayal}, editor = {Pablo Muriel}, url = {https://www.sciencedirect.com/science/article/abs/pii/B978012804274800059X?via%3Dihub}, doi = {10.1016/b978-0-12-804274-8.00059-x}, isbn = {9780128042748}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, booktitle = {Liver Pathophysiology: Therapies and Antioxidants}, pages = {817-836}, publisher = {Academic Press}, address = {Boston}, chapter = {59}, abstract = {Liver cirrhosis is one of the major causes of morbidity and mortality worldwide. Liver transplantation is the only successful and curative option for the management of this disease. However, cost effectiveness, timely availability, operative risks, need of life-long immunosuppressant, and shortage of donor organs are major challenges to fulfill the demand. Stem cells transplantation has emerged as a bridge to liver transplantation for the repopulation of cirrhotic liver due to its potential for long-term proliferation. Human fetal liver–derived stem/progenitor cells (fLSPCs) are emerging as safe and effective therapeutic possibility in the management of liver cirrhosis due to their low immunogenicity and high proliferative ability. Combination of mesenchymal stem cells with fLSPCs could be the best option to ameliorate immunomodulation, fibrotic reconstruction, and repopulation of lost hepatocytes to replenish the deficient liver functions. Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {inbook} } @article{Khan_2017e, title = {Immunophenotypic and molecular analysis of human dental pulp stem cells potential for neurogenic differentiation}, author = {Aleem Ahmed Khan and Nikhat Fatima and Sandeep Kumar Vishwakarma}, url = {https://journals.lww.com/cocd/fulltext/2017/08010/immunophenotypic_and_molecular_analysis_of_human.16.aspx}, doi = {10.4103/ccd.ccd_998_16}, issn = {0976-2361}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, journal = {Contemporary Clinical Dentistry}, volume = {8}, issue = {1}, pages = {81-89}, publisher = {Medknow}, abstract = {Background: Growing evidence shows that dental pulp (DP) tissues could be a potential source of adult stem cells for the treatment of devastating neurological diseases and several other conditions. Aims: Exploration of the expression profile of several key molecular markers to evaluate the molecular dynamics in undifferentiated and differentiated DP-derived stem cells (DPSCs) in vitro. Settings and Design: The characteristics and multilineage differentiation ability of DPSCs were determined by cellular and molecular kinetics. DPSCs were further induced to form adherent (ADH) and non-ADH (NADH) neurospheres under serum-free condition which was further induced into neurogenic lineage cells and characterized for their molecular and cellular diversity at each stage. Statistical Analysis Used: Statistical analysis used one-way analysis of variance, Student's t-test, Livak method for relative quantification, and R programming. Results: Immunophenotypic analysis of DPSCs revealed >80% cells positive for mesenchymal markers CD90 and CD105, >70% positive for transferring receptor (CD71), and >30% for chemotactic factor (CXCR3). These cells showed mesodermal differentiation also and confirmed by specific staining and molecular analysis. Activation of neuronal lineage markers and neurogenic growth factors was observed during lineage differentiation of cells derived from NADH and ADH spheroids. Greater than 80% of cells were found to express β-tubulin III in both differentiation conditions. Conclusions: The present study reported a cascade of immunophenotypic and molecular markers to characterize neurogenic differentiation of DPSCs under serum-free condition. These findings trigger the future analyses for clinical applicability of DP-derived cells in regenerative applications.}, key = {pmid28566856}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Ur-Rehman_2017, title = {Refractive errors among school-going children in Hyderabad}, author = {Mohammed Zain Ur-Rehman and Sultan Rizwan Ahmad and Mariya Syed}, url = {https://www.bibliomed.org/mnsfulltext/67/67-1479278599.pdf?1669792606}, doi = {10.5455/ijmsph.2017.116342212016}, issn = {2277-338X}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, journal = {International Journal of Medical Science and Public Health}, volume = {6}, issue = {4}, pages = {703-706}, abstract = {Background: Uncorrected refractive error is the leading cause of eye problem worldwide. Children are more vulnerable because it starts in school age and can hinder the learning process and educational achievement. Objectives: The objectives of the study were to assess the prevalence of known case of refractive error among school-going children and its socioeconomic characteristics, and attitude of the students toward corrective measure. Materials and Methods: A study was conducted among school-going children from 6th to 10th standard from three schools. Permission was taken from the respective school’s authority and consent was taken from parents through school. Each school had about 300 students, making a total of 900. Students are known to have refractive errors were included in the study. Out of 900, 190 were known to be affected. Data were collected using predesigned questionnaire and analyzed by appropriate statistical tests. Results: The prevalence of known case of refractive error was 21%. Maximum (51%) were between 11 and 12 years of age. About 95% of affected students had myopia. Majority of the students (54.2%) had blurring of vision as their initial complaint. Regarding family history of refractive errors, 65% of the student’s fathers were affected, 49% mothers were affected, and 43% of the siblings were affected. Almost 100% of the students used glasses and only 50% of the students get their eyes checked every 6 months. About 48% of students spent >2 h in front of screen and 47% students spent <2 h in outdoor activities. Conclusion: The prevalence of refractive error was very high; hence, school health services including eye screening should be given special attention.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Anjum_2016, title = {Disability status of leprosy patients enrolled in a tertiary health centre in a metropolitan city}, author = {Vaseem Anjum and M. S. K. Swarupa and Rajesh Neeluri}, url = {https://www.ijl.org.in/article-detail/89/207}, year = {2017}, date = {2017-01-01}, urldate = {2017-01-01}, journal = {Indian Journal of Leprosy}, volume = {89}, pages = {15-22}, abstract = {Study of disabilities in leprosy remains an important aspect as these lead to daily activity restrictions, loss of job, financial constraints, psychological burden, personnel and social stigma. This study has been carried out to study the socio-demographic profile, socio-cultural aspects and various Disability prevention and medical rehabilitation services available for the leprosy patients in the health centre in a South India urban settings. It is descriptive cross-sectional study carried out at tertiary health centre at Hyderabad, Telangana, South India for three months during September to November 2015. A semi structured questionnaire was used to get complete information about the disease, treatment, disability and services utilized by the patients. A total of 54 leprosy patients were enrolled which included 68% males and 32 % females. 2/54 (3.7%) were children. Multibacillary type was seen in 94.4% and slit skin smears were positive 35% of patients had positive for acid fast bacilli (AFB). Deformities were presenting complain in 18/54 (33.3%) patients, another 11 had disability before coming to the facility but it was not possibly main concern., thus in 29/54 patients (53.7%) the deformity developed before starting MDT. 57% of patients felt benefitted from Disability Prevention and Medical Rehabilitation (DPMR) services. While the patients studied cannot be considered as representative of patient population in this city or region, development of deformities before start of MDT indicates delayed diagnosis in a section of society. Similarly a big proportion of patients' disabilities despite MDT indicates the need for improvement in management practices for reactions and nerve damage.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2016c, title = {Think out of the box}, author = {Mohammed Abdul Hannan Hazari}, url = {https://amphysiol.com/index.php/amp/article/view/v1i1.254258}, doi = {10.23921/amp.2017v1i1.254258}, issn = {2456-8422}, year = {2016}, date = {2016-12-31}, urldate = {2016-12-31}, journal = {Annals of Medical Physiology}, volume = {1}, issue = {1}, pages = {1-2}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Bahmed_2016, title = {Relation between respiratory rate and heart rate - A comparative study}, author = {Farah Bahmed and Farisa Khatoon and Barra Ram Reddy}, url = {https://www.ijcap.org/article-details/2970}, doi = {10.5958/2394-2126.2016.00099.2}, issn = {2394-2118}, year = {2016}, date = {2016-12-31}, urldate = {2016-01-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {4}, pages = {436-439}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Background: Activity of many physiological subsystems has a well-developed rhythmic character. Often a dependency between physiological rhythms is established due to interaction between corresponding sub-systems. A well-known feature of oscillatory systems and biological oscillators in particular, is their ability to synchronize. The cardiac and respiratory systems each function is an oscillatory manner, providing a nice example of coupled biological oscillators. The present study has been conducted to evaluate the relation between Respiratory rate and Heart rate and comment upon frequency coupling involved in cardiovascular and Respiratory systems. Materials and Methods: 40 conscious healthy adults belonging to both sexes were screened using standardized digital physiograph. Piezoelectric respiratory belt was used for respiratory recording. A bipolar limb lead ECG was used for cardiac activity. Results: The data of healthy subjects showed strong variability in heart rate and respiratory rate in a 15 minute recorded segment and subjected to fast Fourier Transforms. Conclusion: We thereby conclude that frequency coupling is the important aspect of cardio-respiratory interaction as we detected the presence of several different n: m epochs within one record.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2016, title = {Effect of henna (mehndi) on pulse oximetry reading}, author = {Nazia Uzma and Juveria Sultana and Abid Ali Khan and Usama Syed and Ashfaq Hasan}, url = {https://www.ijcap.org/article-details/2998}, doi = {10.5958/2394-2126.2016.00127.4}, issn = {2394-2118}, year = {2016}, date = {2016-12-31}, urldate = {2016-01-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {4}, pages = {556-559}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Introduction: Pulse oximetry is a frequently used and a non-invasive method for monitoring oxygen saturation in blood. It estimates arterial hemoglobin saturation by measuring the light absorbance of pulsating vascular tissue at two wavelengths which can be altered by various factors. Numerous factors could lead to inaccuracy or ambiguous information about oxygen saturation and might result in unwanted procedures. In many cultures, women decorate their fingernails and feet with henna. The purpose of this study was to determine the effect of henna on the measurement of oxygen saturation. Methods: 100 healthy females with a mean age of 19±1.0 years with normal oxygen saturation at room air were included into the study. Individuals with cardiovascular disorders like congenital heart disease, heart failure, any respiratory diseases were excluded from the study. Henna was applied to all the participants on the distal phalanx of left index finger (test) of the individuals and kept for 2 hours whereas right index finger was left empty as control. After 2 hours of application, henna was scrapped off from left finger. Oxygen saturation in addition to radial pulse was determined on both tested and control finger. Similarly, oxygen saturation and radial pulse was again determined on 2nd day as well as on the 7th day of application of henna on both tested and control finger and were statistically compared. Results: Our results revealed no alteration in radial pulse after henna application even after 07th day (p value more than 0.05 in all the cases). However, a change in oxygen saturation was observed after 2 hours of application of henna till 07th day. Nonetheless, it must be emphasized that an increase of saturation of this minor magnitude (average 0.67%) does not translate into a clinically important change. Conclusion: Application of natural henna does not cause any major error in measurement of oxygen saturation in young healthy individuals.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Masih_2016, title = {Evaluation of serum levels of trace elements, malondialdehyde, ceruloplasmin in the development of preeclampsia}, author = {Syed Shabbar Masih and Syyeda Anees and Shaikh Mahmood}, url = {https://ijirms.in/index.php/ijirms/article/view/60}, doi = {10.23958/ijirms/vol01-i07/06}, issn = {2455-8737}, year = {2016}, date = {2016-12-25}, urldate = {2016-12-25}, journal = {International Journal of Innovative Research in Medical Science}, volume = {1}, issue = {7}, pages = {342-348}, abstract = {Preeclampsia is a pregnancy-specific condition that increases maternal and fetal mortality and morbidity. Despite its prevalence and severity, the patho-physiology of this multisystem disorder is poorly understood and its etiology has not yet been fully elucidated. This study was aimed to evaluate the role of trace elements copper, zinc, magnesium, antioxidant ceruloplasmin (Cp) and lipid peroxidation product malondialdehyde (MDA) in the pathogenesis of preeclampsia. The results showed increased levels of serum copper, Cp and MDA in normal pregnant women (group II) and in pregnant women with preeclampsia (group III) when compared to normal non pregnant women (group I), ( P< 0.001). Further these levels were higher in group III when compared to group II (P< 0.001). Serum levels of zinc were significantly decreased in group II when compared to group I (P< 0.001) and were significantly lower in group III when compared to group II (P< 0.001). There was no significant difference in serum magnesium levels in controls and cases (P= 0.2927). The findings suggest that lipid peroxidation along with imbalance of antioxidants of micronutrients may be an important factor in the pathogenesis of preeclampsia.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2016, title = {Knowledge, attitude and practice regarding hepatitis B among medical students}, author = {Syed Faisal Hussain and Sultan Rizwan Ahmad and Osman Mohammed Muslehuddin and Husam Mohammed Muslehuddin }, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/56/54}, doi = {10.18203/2394-6040.ijcmph20163484}, issn = {2394-6032}, year = {2016}, date = {2016-12-22}, urldate = {2016-12-22}, journal = {International Journal of Community Medicine and Public Health}, volume = {3}, issue = {11}, pages = {2977-2981}, abstract = {Background: Hepatitis means inflammation of the liver cells. Main cause of hepatitis is viral infection by hepatitis B virus. Hepatitis B is a serious, global, public health problem that gives rise to hepatocellular carcinoma with a mortality rate of about 600000 people worldwide. Medical students are also vulnerable to acquire this infection. Methods: A cross-sectional study aimed to evaluate knowledge, attitude and practice regarding spread, risk factors, diagnosis and treatment of Hepatitis B was undertaken amongst 341 undergraduate medical students using a standardized questionnaire. In addition to this awareness regarding post exposure prophylaxis and vaccination status of hepatitis B among the students were also studied. Results: In the present study 98.8% of medical students had correct knowledge regarding vaccine for hepatitis B. Study showed good knowledge regarding spread and risk factors for hepatitis B. 98.5% of the students gave the correct answer that hepatitis B is diagnosed by hepatitis markers test. Regarding treatment, 98.2% said that vaccination is the choice for treatment of hepatitis B. With respect to post exposure prophylaxis 97.1% said that vaccination is main source of post exposure prophylaxis and 91.8% said that HBIg is used for post exposure prophylaxis. Regarding the vaccination status of students for hepatitis B, 26.7% were fully vaccinated and 36.4 % were partially vaccinated and 37% were unvaccinated. Conclusions: This study showed that knowledge and attitude of medical students are good towards hepatitis B but practice is not sufficient as 1/3rd of students are unvaccinated. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2016c, title = {Health profile of pregnant women attending urban health centre in Hyderabad, Telangana, India}, author = {Sultan Rizwan Ahmad and Mehaboobi Shaik and A. Chandrasekhar}, url = {https://www.ijcmph.com/index.php/ijcmph/article/view/138/135}, doi = {10.18203/2394-6040.ijcmph20163936}, issn = {2394-6032}, year = {2016}, date = {2016-12-22}, urldate = {2016-12-22}, journal = {International Journal of Community Medicine and Public Health}, volume = {3}, issue = {11}, pages = {3202-3206}, abstract = {Background: Maternal and child mortality is the outcome of multiple factors. Current maternal mortality in India is 254 per 100,000 live births. Improving the maternal and child health is an important public health goal of government of India. To prevent unwanted outcome of pregnancy, antenatal care (ANC) is most important method for early detection and prompt treatment of complications. Methods: A cross sectional study was conducted among pregnant women attending ANC clinic at urban health centre during September 2015 to November 2015. A pre tested semi-structured questionnaire was used for data collection. Data was collected from 102 pregnant women attained ANC clinic during study period. The data was compiled and analyzed using appropriate statistical tools. Results: In present study majority (46%) of pregnant ladies belong to 20-25 years of age group and 26% had consanguinous marriage. In our study gravida 3, gravida 4 and gravid 5 were 29%, 12% and 5% respectively. 52 % of pregnant ladies had 3 ANC visit, almost 62% of pregnant ladies had done haemoglobin examination and 57% blood grouping testing. Pregnancy outcome were live birth in 82.66 % and abortion in 16.69%. 41% were previous LSCS and 9% were home delivery. In this study we found that high risk pregnancy were 59.8% and main reason of being high risk were previous LSCS (52%), anaemia (40%). Conclusions: High quality antenatal care as well as knowledge and practice of community regarding maternal care during pregnancy are important to unwanted outcome of pregnancy.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Naseem_2016, title = {A study to evaluate the knowledge, attitude and practices of exclusive breast feeding among primi mothers of healthy term neonates in a tertiary care hospitals and predictors of failures of establishment of exclusive breast feeding in first six months}, author = {Altaf Naseem and Naila Mazher}, url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/25/23}, doi = {10.18203/2349-3291.ijcp20161589}, issn = {2349-3283}, year = {2016}, date = {2016-12-21}, urldate = {2016-12-21}, journal = {International Journal of Contemporary Pediatrics}, volume = {3}, issue = {3}, pages = {810-814}, abstract = {Background: In India about 2.4 million children die each year of which two thirds are associated with infant feeding practices which are in appropriate. Thirteen percent reduction in infant mortality rate has been estimated with breast feeding. Methods: This study is a cross-sectional questionnaire based study done in the setting of pediatric outpatient department at Owaisi hospital and research center Hyderabad. It was carried out over a duration of two years from 2013 to 2015. Results: Majority of mothers received antenatal counselling regarding benefits and management of breast feeding. Conclusions: Majority of the mothers had good knowledge;attitude and practices are still prevalent in the community which needs to be addressed.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Naseem_2016b, title = {Comprehensive study of health problems in school children of Hyderabad, India}, author = {Altaf Naseem and Nayantara G. Rao}, url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/23/21}, doi = {10.18203/2349-3291.ijcp20161470}, issn = {2349-3283}, year = {2016}, date = {2016-12-21}, urldate = {2016-12-21}, journal = {International Journal of Contemporary Pediatrics}, volume = {3}, issue = {3}, pages = {801-805}, abstract = {Background: It is estimated that over one-fifth of our population comprises of children aged 5-14 years and only 80% of these children are enrolled in schools. A child spends most of the time in school and it is considered an ideal place for learning and growing up of a child. In India due to poverty and prevailing socio-cultural milieu a substantial number of school children suffer from various diseases which can be prevented if diagnosed and treated early. We conducted this study to evaluate the health and the nutritional status of school children and comparison was drawn between the rural and urban school children. Methods: This is a cross sectional prospective study where a total of 500 school children from rural and urban government schools were thoroughly assessed by a detailed clinical examination including anthropometry. Results: It was observed that more than half of the children from both rural (56%) and urban (58%) schools were under nourished. The BCG vaccination coverage was better in urban school children (86.5%), with an overall coverage of 80%. Various other problems were more prevalent in rural school children except respiratory diseases which were observed to be more prevalent in urban school children (7.2%). Conclusions: It was learnt that the morbidity of school age children from the community’s perspective is entirely different from morbidity from health care professional’s perspective. Therefore, educating the community will go a long way in improving the quality of life.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Farheen_2016, title = {Prescription pattern of non-steroidal anti-inflammatory drugs in patients with acute musculoskeletal pain}, author = {Humaira Farheen and Ghulam Subhani and Mohammed Mohsin}, url = {https://www.ijbcp.com/index.php/ijbcp/article/view/41/39}, doi = {10.18203/2319-2003.ijbcp20164113}, issn = {2279-0780}, year = {2016}, date = {2016-12-21}, urldate = {2016-12-21}, journal = {International Journal of Basic and Clinical Pharmacology}, volume = {5}, issue = {6}, pages = {2504-2509}, abstract = {Background: Without the knowledge on how drugs are being prescribed and used, it is difficult to initiate a discussion on rational drug use and to suggest measures to change prescribing habits for the better information on the past performance of prescribers is linchpin of any auditing system. The objective of the study was to assess the NSAIDs prescription pattern in patients with MS pain. Methods:Prospective study of prescriptions of 306 patients with MS pain presenting in orthopedic outpatient department (OPD) of Owaisi Health and Research Centre during the period of January 2014 to August 2015. Patient particulars, history and clinical findings were obtained using the study proforma. Data collected was analyzed by frequency, and percentage. Results:Overall frequency of NSAIDs prescription in this study was 96%. Diclofenac (70.7%) was the commonest NSAID prescribed. Selective COX-2 inhibitors were not prescribed. Combination of paracetamol and tramadol (77%) was the commonest FDC prescribed among the 92 FDC prescriptions. High frequency of GPAs co-prescription (94%) was noted. Of 7 different NSAIDs prescribed, 2 drug (diclofenac, and paracetamol) falls within DU90% segment-mainly constituted by non-selective NSAIDs. Conclusions:Overall, the prescription pattern was in accordance with standard guidelines, as suggested by the fact that the DU90%, segment was constituted by only few drugs.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2016b, title = {A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism}, author = {Mayana Kaleemullah Khan and Mohammed Nasir Mohiuddin}, url = {https://www.msjonline.org/index.php/ijrms/article/view/152/181}, doi = {10.18203/2320-6012.ijrms20162911}, issn = {2320-6012}, year = {2016}, date = {2016-12-18}, urldate = {2016-12-18}, journal = {International Journal of Research in Medical Sciences}, volume = {4}, issue = {9}, pages = {3934-3938}, abstract = {Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients. Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females. Results: In present study 25 cases of age group 41-65 years there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia. Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2016b, title = {Effect of proteinuria in diabetes mellitus}, author = {Anjum Sultana Khatoon and Raisa Faheem}, url = {https://www.jebmh.com/abstract/effect-of-proteinuria-in-diabetes-mellitus-82118.html}, issn = {2349-2562}, year = {2016}, date = {2016-12-08}, urldate = {2016-12-08}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {98}, pages = {5404-5412}, abstract = {BACKGROUND: Diabetic nephropathy is a dreaded complication of type 2 diabetes mellitus. However, in the early stages, also known as incipient nephropathy, it can be detected by presence of proteinuria. The aim of our study is to know the occurrence of proteinuria in patients with type 2 diabetes mellitus and to note its associations with the duration of diabetes since diagnosis and also the various macrovascular and microvascular complications of diabetes mellitus. MATERIALS AND METHODS: This study was undertaken in Princess Esra Hospital/DCMS - Hyderabad. A total of one hundred randomly selected diabetic patients satisfying the inclusion criteria were selected for the study. All patients were evaluated in detail along with the testing for proteinuria with dipsticks (Micral). RESULTS: The overall occurrence of proteinuria was 38%. The occurrence of proteinuria showed a direct relationship with increasing age (p=0.053) and increasing duration of diabetes since diagnosis. An HbA1c value above 7% is associated with 50% or higher incidence of proteinuria (p=0.018). Patients with a body mass index of more than 25 kg/m2 have significant increase in the incidence of proteinuria (p=0.027). The incidence of proteinuria is significantly associated with the presence of retinopathy (p=0.073), peripheral neuropathy (p=0.009), ischaemic heart disease (p=0.011) and hypertension (p=0.001). Proteinuria is inversely associated with HDL (p=0.089). CONCLUSION: The occurrence of proteinuria in type 2 diabetic patients of Hyderabad was quite high. During the evaluation of diabetic patients, the possibility of proteinuria and its correlation with various complications of diabetes mellitus should be kept in mind.}, keywords = {Biochemistry, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khan_2016e, title = {Comparative study on various adjuvants used during spinal anaesthesia in infraumbilical surgeries}, author = {Basheer Ahmed Khan and Mohammed Mohib Hussain and Jaweed Zaheer Siddique and Naseeba Fatima and Santosh Singh}, url = {http://www.jcmad.com/admin/pdf/435.pdf}, issn = {2347-4513}, year = {2016}, date = {2016-12-06}, urldate = {2016-12-06}, journal = {Journal of Contemporary Medicine and Dentistry}, volume = {4}, issue = {3}, pages = {27-32}, abstract = {This prospective randomized double-blind study was conducted to evaluate the onset and duration of sensory and motor block as well as perioperative analgesia and adverse effects of various adjuvants like dexmedetomidine, magnesium sulphate, fentanyl given during spinal anaesthesia with 0.5% hyperbaric bupivacaine for central neuraxial block. A total of 120 patients were randomly allocated into four groups to receive intrathecally either 15 mg hyperbaric bupivacaine plus 10 μg dexmedetomidine (group A, n =30) or 15 mg hyperbaric bupivacaine plus 50 mg magnesium sulfate (group B, n =30) or 15 mg hyperbaric bupivacaine plus 25 μg fentanyl (group C, n =30) or 15 mg hyperbaric bupivacaine plus 0.1 ml saline (group D, n =30) as control. The onset time to reach peak sensory and motor level, the regression time for sensory and motor block, hemodynamic changes and side-effects were noted. The Ɵme of onset to reach T10 dermatome level and to reach peak sensory level as well as the onset time to reach modified Bromage 3 motor block were significantly different in all the four groups. The onset time to reach peak sensory and motor level was shorter in group A as compared with the control group C, and it was significantly prolonged in group B. It was also found that patients in group A had significant longer sensory and motor block times when compared to patients in group B, which was greater than in the fentanyl group C and control group D. In this study it was found that onset of anaesthesia was rapid and of prolonged duration in the dexmedetomidine group (A). However, in the magnesium sulfate group (B), although onset of block was delayed, the duration was significantly prolonged as compared with the fentanyl group (C) and control group (D), but to a lesser degree than in the dexmedetomidine group (A). All the groups were similar with respect to hemodynamic variables and there were no significant side-effects in either of the groups. }, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Mathai_2016, title = {Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to hajj pilgrims}, author = {Dilip Mathai and Abul Khair Mohammad Shamsuzzaman and Ahrar Ahmed Feroz and Amin R. Virani and Ashfaq Hasan and K. L. Ravi Kumar and Khalid Ansari}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126751/pdf/JGID-8-129.pdf}, doi = {10.4103/0974-777X.193749}, issn = {0974-777X}, year = {2016}, date = {2016-12-01}, urldate = {2016-12-01}, journal = {Journal of Global Infectious Diseases}, volume = {8}, pages = {129-138}, abstract = {Respiratory tract infections are prevalent among Hajj pilgrims with pneumonia being a leading cause of hospitalization. Streptococcus pneumoniae is a common pathogen isolated from patients with pneumonia and respiratory tract infections during Hajj. There is a significant burden of pneumococcal disease in India, which can be prevented. Guidelines for preventive measures and adult immunization have been published in India, but the implementation of the guidelines is low. Data from Bangladesh are available about significant mortality due to respiratory infections; however, literature regarding guidelines for adult immunization is limited. There is a need for extensive awareness programs across India and Bangladesh. Hence, there was a general consensus about the necessity for a rapid and urgent implementation of measures to prevent respiratory infections in pilgrims traveling to Hajj. About ten countries have developed recommendations for pneumococcal vaccination in Hajj pilgrims: France, the USA, Kuwait, Qatar, Bahrain, the UAE(Dubai Health Authority), Singapore, Malaysia, Egypt, and Indonesia. At any given point whether it is Hajj or Umrah, more than a million people are present in the holy places of Mecca and Madina. Therefore, the preventive measures taken for Hajj apply for Umrah as well. This document puts forward the consensus recommendations by a group of twenty doctors following a closed-door discussion based on the scientific evidence available for India and Bangladesh regarding the prevention of respiratory tract infections in Hajj pilgrims. }, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2016, title = {Ultrasound imaging of gallbladder variants}, author = {Syeda Nasreen Fatima and Syeda Naziya Parveen}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0003277817300163?via%3Dihub}, doi = {10.1016/j.jasi.2017.01.011}, issn = {0003-2778}, year = {2016}, date = {2016-12-01}, urldate = {2016-12-01}, journal = {Journal of the Anatomical Society of India}, volume = {65}, issue = {2}, pages = {118-122}, publisher = {Elsevier}, abstract = {Introduction: This article examines the variations and anomalies of gallbladder. This study is highly useful for surgical purposes where there is always a lot of variations seen, to prevent misdiagnosis and to aid in evaluation of differential diagnostic possibilities. Methods: Ultrasonography was used to perform this study. Result: This study demonstrates wide array of variants including anomalies in location, number and configuration. The present study shows that there is double gallbladder found in 1%, kinking of posterior wall of gallbladder in 15%, Phrygian cap deformity in 7%, curved gallbladder found in 1%, intrahepatic gallbladder observed in 9%, transverse gallbladder detected in 7% and the gallbladder is located under the left lobe of liver in 2% of the cases. Normal location in right Hypochondrium is seen in 81 subjects. Discussion: The present study shows various anomalies of gallbladder that can be diagnosed prior to the surgery, so as to avoid misdiagnosis that could cause any fatality.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Siddiqui_2016, title = {A study on fatal organophosphorous poisoning cases with respect to age and sex}, author = {Abdul Rahman Omer Siddiqui and Iqbal Banu Hussain}, url = {https://www.ijfmt.com/scripts/IJFMT%20July-Dec%202016%20.pdf}, doi = {10.5958/0973-9130.2016.00091.8}, issn = {0973-9122}, year = {2016}, date = {2016-12-01}, urldate = {2016-12-01}, journal = {Indian Journal of Forensic Medicine & Toxicology}, volume = {10}, issue = {2}, pages = {188-192}, abstract = {The incidence of Organo-phosphorous poisoning has steadily increased in past and created many serious problems since these compounds are been preferred in most suicides. The present study deals with the incidence of Organo-phosphorous poisoning on different persons of different age and sex. The study reveals that Age group between 21-30 years (42% cases) has maximum fatalities and minimum fatalities are noted in the extremes of age.}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2016, title = {Utility of geriatric depression scale-15 for assessment of depression among elderly:a cross sectional study}, author = {Mohammed Sarosh Ahmed and Padmaja R. Walvekar and Sameeran S. Chate and M. D. Mallapur}, url = {https://ijphrd.com/scripts/IJPHRD%20Oct-Dec%202016.pdf}, doi = {10.5958/0976-5506.2016.00208.4}, issn = {0976-0245}, year = {2016}, date = {2016-12-01}, urldate = {2016-12-01}, journal = {Indian Journal of Public Health Research and Development}, volume = {7}, issue = {4}, pages = {150-154}, abstract = {Introduction: Depression in elderly is often overlooked as a clinical diagnosis, since it is assumed to be a normal response to ageing. In India, its prevalence ranges from 11 to 32% and is found to be significantly higher than the rest of the world. Earlier recognition of depression and its risk factors can reduce the morbidity and improve the quality of life. Hence this study was undertaken to assess the utility of Geriatric Depression Scale-15 to detect depression and its associated risk factors among elderly. Method: A cross sectional study, conducted from January to December 2014 among 850 adults aged 60 years and above residing in Ashok Nagar area, Belagavi. Data was collected by house to house visit using a predesigned questionnaire, which included socio-demographic details and Geriatric Depression Scale-15 (GDS- Short Form). Results: The prevalence of depression using Geriatric Depression Scale-15 was found to be 36.7%, with a higher preponderance in women than men (40.8% vs 32.3%). Advancing age, disrupted marital status, lower socio economic status and sedentary lifestyle were significantly associated with depression (p<0.05). Conclusion: Our study demonstrated a significant higher prevalence of depression and identified its risk factors in urban population of South India. Steps needs to be taken at the earliest to reduce the suffering and improve the quality of life among elderly. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Prabhakar_2016, title = {Renal dysfunction in burn injuries significance of hypovolaemia, azotemia And hyperkalemia}, author = {M. Prabhakar and Mohammed Abbas Hyder and Syyeda Anees and N. Sudershan Rao and Shaikh Mahmood}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=November_2016_1496064296__115.pdf}, issn = {2277-8179}, year = {2016}, date = {2016-11-30}, urldate = {2016-11-30}, journal = {International Journal of Scientific Research}, volume = {5}, issue = {11}, pages = {86-87}, abstract = {Burn injury is a major cause of Acute renal failure. It is very common and leads to mortality. Finally it results in a complex interplay of various cellular and neuro – hormonal changes. In severe burn patients there will be a continuous homeostatic alteration. The aim of this study is to present the salient features in burn patients. There is a comprehensive understanding of the global physiologic changes underlying the condition of burn patients and a judicious interpretation of their continuous homeostatic alterations. Extensive burn injury encompass not only the coetaneous wound but also systemic changes associated with serious pathophysiological complications, one of which is acute renal failure the incidence of acute renal failure in burn patients has been shown to vary widely from 1% to 30% and is associated with 73% to 100% mortality . Acute renal failure as an abrupt decrease in the glomerular filtration rate (GFR) cause by intrinsic parenchymal disease or alterations in intrarenal hemodynamics. Its major manifestation is the accumulation of water, urea, creatinine, and potassium in the blood. }, keywords = {Biochemistry, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Khurram_2016, title = {A study of evaluation of iron deficiency as a risk factor for febrile seizures}, author = {Mir Sumsam Ali Khurram and Uppin Narayan Reddy}, url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/200/397}, doi = {10.17511/ijpr.2016.11.11}, issn = {2349-3267}, year = {2016}, date = {2016-11-30}, urldate = {2016-11-30}, journal = {Pediatric Review:International Journal Pediatric Research}, volume = {3}, issue = {11}, pages = {826-830}, abstract = {Objective: To estimate the incidence of seizure of iron deficiency anemia in febrile seizure. To determine the clinical correlates of children with febrile seizures. Methods: In this case, control study was conducted among 126 children of age group between 6 months and 5 years during April 2015 to April 2016. The control case groups were matched based on the family history of febrile seizure, age, sex, and temperature. Blood samples were collected. Measured quantities of serum feritin, hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin were compared. Result: 36 children (28.5%) in the febrile Seizure group have positive family history when compared to none among controls. Serum ferritin level in febrile seizure group is found to have 14.5+/-10.6 ng/ml, where as in controls it is 34.9+/-23.3 ng/ml .The mean hemoglobin was 9.8+/-1.2 gm/dl whereas in controls, it was 11.3+/-1.1gm/dl. The mean corpuscular volume is 76+/-8.5fl, whereas in control it is 79.5+/-7.5fl, which was statistically significant. The mean corpuscular hemoglobin was 27.7+/-3.1pg and for control it was 28.7/3.6 pg. Conclusion: Serum ferritin, Hb% and MCV were found to be significant on the lower side in children with febrile seizure when compared to the children who did not have febrile seizure.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Mahmood_2016b, title = {Hypoproteinemia, hypocalcemia, hyponatraemia, hyperkalaemia and trace elements in patients with burn injuries}, author = {Shaikh Mahmood and M. Prabhakar and Syyeda Anees and Mohammed Abbas Hyder}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/October_2016_1496311589__199.pdf}, isbn = {2277-8179}, year = {2016}, date = {2016-10-31}, urldate = {2016-10-31}, journal = {International Journal of Scientific Research}, volume = {5}, issue = {10}, pages = {558-559}, abstract = {The present study illustrates the changes in total proteins, electrolytes and trace elements in serum of patients with burn injuries. The levels of these substances are very important in diagnosis and the therapy of the patients. A total of 65 patients and 100 healthy controls were enrolled in this study. These patients were admitted to the burns ward at Owaisi Hospital & Research Centre, a teaching hospital to Deccan College of Medical Sciences, Hyderabad, Telangana State, India with 25 – 30% degree of burn. They were suffering from second to third degree (flame and scald) burn injury. The results showed a statistically significant decrease in levels of serum total proteins, calcium, sodium, copper and zinc where as serum potassium levels were significantly increased in burn injuries.}, keywords = {Biochemistry, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2016d, title = {Family health survey: community diagnosis conducted in an urban field practice area of Hyderabad}, author = {Sultan Rizwan Ahmad and Syed Faisal Hussain and Osman Mohammed Muslehuddin and Husam Mohammed Muslehuddin and Sandeep Mane and A. Chandrasekhar}, url = {https://publichealth.medresearch.in/index.php/ijphr/article/view/53/71}, doi = {10.17511/ijphr.2016.i5.05}, issn = {2349-4158}, year = {2016}, date = {2016-10-31}, urldate = {2016-10-31}, journal = {Public Health Review: International Journal of Public Health Research}, volume = {3}, issue = {5}, pages = {210-215}, abstract = {Background: In India, routine reporting of health status by the health and social welfare functionaries is suboptimal. Surveys to assess the health status and living conditions of population are essential to monitor the ongoing health problems and initiate appropriate intervention. Through community diagnosis and health survey students are more exposed to various disease patterns in the community, which creates better prospect to practical learning. Material & Methods: A community diagnosis survey was done in urban field practice area by the department of Community Medicine, Deccan College of Medical Sciences, Hyderabad. A group of 4 students were given 25 families each, for a total of 100 families to survey their health status and socio-demographic factors. Information was collected related to their present health status, socioeconomic status, housing pattern, sanitation measure, and immunization status of under five children etc. Data was analyzed by appropriate tools. Results: In this survey 96% were Muslim families. Nuclear families were 81%. Majority i.e. 40% of the families belongs to class II and overcrowding was present in 28% of families. In these 100 family total population was 492 individuals. 8% of study population was under five years of age and nearly 4% was geriatric above 60 years of age. Female were more (50.6%) than male (49.4%). Crude literacy rate in study population was 78%. Prevalence of morbidity was 13.4%. Common morbidity was hypertension, diabetes and joints pain. 82% were fully vaccinated, 16% were partially vaccinated and 2% were unvaccinated. Conclusion: Through family health survey health need of community can be identified and medical students can also be sensitized to function as community physician.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2016, title = {Does anthropometric measurements correlate with hematological parameters after the adolescent growth period?}, author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari}, url = {https://ppj.phypha.ir/article-1-1166-en.html}, issn = {2476-5236}, year = {2016}, date = {2016-09-30}, urldate = {2016-09-30}, journal = {Physiology and Pharmacology}, volume = {20}, issue = {3}, pages = {137-146}, publisher = {Iranian Society of Physiology and Pharmacology}, abstract = {Introduction: Musculoskeletal growth is variable during adolescent period and reaches its maximum by 18 years, whereas hemopoietic parameters reach adult values by 15 years. After adolescence period, the blood parameters may vary with nutrition and built of the individual. The purpose of this study was to find out any correlation between anthropometric and hematological parameters after the adolescent growth period. Methods: Total of 81 subjects (males: 20; females: 61), 18-22 years were analyzed for 4 anthropometric measures and 19 hematological markers. Blood was collected in citrate tubes and analyzed for hematological parameters. Results: Difference between BMI sub-groups with respect to hemoglobin (Hb), red cell distribution width-standard deviation (RDW-SD) and red cell distribution width-coefficient of variation (RDW-CV) in males and females was not significant. In males, height showed negative correlation with mean corpuscular hemoglobin concentration (MCHC) and weight showed positive correlation with hematocrit. BMI positively correlated with Hb. Body surface area (BSA) correlated with red blood cell count (RBC) and hematocrit. In females, height, weight and BSA did not show significant correlation with any of the blood parameters. BMI correlated positively with mid-cell fraction and negatively with mean platelet volume. RDW-SD and RDW-CV did not reveal any statistically significant correlation with height, weight, BMI and BSA in both males and females. Conclusion: In male subjects, hemoglobin concentration positively correlated with BMI whereas RBC count and hematocrit correlated with BSA. In females no such association was noted. RDW did not show any correlation with anthropometric measures in both genders.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2016b, title = {A study of psychiatric morbidity in patients attending the medical gastro enterology unit in a teaching hospital}, author = {Arifuddin Ahmed and Rajini Tenali and Faheemuddin Naveed and Ramakrishna Podaralla}, url = {https://ijip.in/pdf-viewer/?id=13888}, doi = {10.25215/0304.216 }, issn = {2348-5396}, year = {2016}, date = {2016-09-30}, urldate = {2016-09-30}, journal = {International Journal of Indian Psychology}, volume = {3}, issue = {4}, pages = {223-237}, abstract = {The World Health Organization defines health a state of complete physical, mental and social wellbeing and not merely the absence of disease or infirmity. This includes the capability to be productive both socially and economically. The functional gastrointestinal disorders (FGIDs) are a heterogenous group of chronic conditions that are considered to have no structural or biochemical abnormalities that account for the symptoms. They are supposed to originate from malfunction of the gut with respect to the nervous mis perception. In these cases, anxiety and or depression could be present mainly in the ‘state’ and or ‘current’ form, reactive to the symptoms. Aim: Descriptive study to assess the socio demographic profile of patients with gastrointestinal disorders. To study the psychiatric morbidity in gastrointestinal disorder patients attending gastrointestinal clinics. Objectives: To study the relationships between factors attributable to gastrointestinal disorders and psychiatric morbidity. To study the effectiveness of GHQ as a screening instrument for psychiatric morbidity in gastrointestinal patients. Sample: 52 patients with gastrointestinal problems of all kinds who attended OPD with age group of 15-65 years. Methods: General Health Questionnaire (GHQ) standardized tool was used. Results: Married patients had higher GAD and MDD compared to unmarried patients. Unemployed and retired people had higher rates of GAD and MDD compared to employ. Students with GI disease had no psychiatric morbidity. All subscales of GHQ showed correlation significantly.}, keywords = {Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2016b, title = {Sub lingual thyroid-a case report}, author = {Syeda Nasreen Fatima and Syeda Sadia Sameera}, url = {https://www.ijcap.org/article-details/2469}, doi = {10.5958/2394-2126.2016.00080.3}, issn = {2394-2118}, year = {2016}, date = {2016-09-30}, urldate = {2016-01-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {3}, pages = {387-392}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Introduction: A sub lingual thyroid anterior to the hyoid bone which is the only thyroid tissue present in the body is a rare entity. It was found due to failure of descent of the thyroid gland to its normal position. Methods: 13 yr. old female presented with symptoms of severe sinusitis. CT scan was used to perform this study. Result: A Sublingual thyroid gland present in front of the hyoid bone is observed and there was complete absence of thyroid gland at normal position. Discussion: Incidence of lingual thyroid gland is reported as 1:100,000. It is manifested more in females.1:7 Ectopic thyroid tissue can occur anywhere from foramen caecum to its normal position i.e.; in front & sides of trachea at the level of 5th, 6th, 7th cervical & 1st thoracic vertebrae in the human body. 70% of patients with lingual thyroid are associated with hypothyroidism and 10% suffer from cretinism. Conclusion: A sublingual thyroid due to failure of descent of the thyroid gland with congenital hypothyroidism. No known pathogenesis is present in this case. Thorough examination with follow up is important. A thyroid profile, hemogram, an x-ray of the neck & thyroid scan has to be done regularly with interval of at least once in 6 months. Unless there is need for emergency surgery, it should not be performed. Patient should be treated symptomatically. There should be hormonal essay done for every child born and treated as early as possible to avoid the consequences. Starting of treatment in patients with congenital problems of hormones can help the patient to lead a normal life.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Khan_2016d, title = {Minimally invasive/percutaneous talus fracture osteosynthesis- a case report}, author = {Mazharuddin Ali Khan and Chinnala Srujan Kumar and Mohammed Amanul Haq Qureshi and Sarosh Haidry}, url = {https://www.iosrjournals.org/iosr-jdms/papers/Vol15-Issue%209/Version-7/Y150907154157.pdf}, doi = {10.9790/0853-150907154157 }, issn = {2279-0853}, year = {2016}, date = {2016-09-30}, urldate = {2016-09-30}, journal = {IOSR Journal of Dental and Medical Sciences}, volume = {15}, issue = {9}, pages = {154-157}, abstract = {The talus is involved in about 2% of all lower extremity injuries and about 5-7% of foot injuries. Fractures of Talus are relatively uncommon and can be associated with significant complications. Because it articulates with important joints i.e.,ankle, subtalar, and talonavicular, it is one of the most important bones to stabilize and mobilize soon after a foot injury. Talar fractures are usually associated with hyperdorsiflexion of the ankle as the talar neck impacts the anterior margin of the tibia, such as in a motor vehicle accident or fall from height. We describe the case of a 21year old male presenting with displaced talus fracture of right leg which was treated with a minimally invasive technique.}, keywords = {Orthopedics}, pubstate = {published}, tppubtype = {article} } @article{Khan_2016, title = {A study on estimation of serum calcium in subclinical hypothyroid females of different age groups and its correlation with thyroid stimulating hormone (TSH)}, author = {Mayana Kaleemullah Khan and Mohammed Nasir Mohiuddin and Nooruddin Owaisi}, url = {https://www.jebmh.com/articles/a-study-on-estimation-of-serum-calcium-in-subclinical-hypothyroid-females-of-different-age-groups-and-its-correlation-wi.pdf.pdf}, doi = {10.18410/jebmh/2016/820}, issn = {2349-2562}, year = {2016}, date = {2016-09-30}, urldate = {2016-09-30}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {71}, pages = {3836-3839}, abstract = {BACKGROUND: Hypothyroidism is a clinical condition arising because of the inadequacy of thyroid hormones or from inability to perform a normal function. Hypothyroidism is a typical metabolic condition in almost all community groups. In India, 42 million individuals are experiencing thyroid disease; hypothyroidism being the commonest thyroid disorder.(1) Serum calcium levels are lower in patients with high TSH than with typical TSH (p <0.01). METHODOLOGY: There were 50 females with SCH were selected in the study. Patients with 18 to 65 years of age, with TSH levels more than 5.0 mIU/L, free T4 within normal limits, and general well-being patients were incorporated. The study period was from January to April 2016. Owaisi Hospital and Research Centre, it is a 1000 bedded hospital with super specialty services in Hyderabad, giving particularly tertiary level human services to all strata of individuals. RESULTS: Out of 50 patients, 24 patients with hypothyroidism are in hypocalcaemia, which constitute 48% (n=24) of the people required in the study had estimation of serum calcium under 9 mg/dL. This shows to be the one of the important concern associated with hypothyroidism. In rest 52% (n=26) of patients who were having normal calcium levels, chances of developing hypocalcaemia in future is high. DISCUSSION: The mean age, serum calcium and thyroid stimulating hormone (TSH) in AlaEldin S. Ashmaik et al was: Age: 32.00±15.76, TSH: 26.02±34.74, and serum calcium: 7.97±.62 while in our study it shows a mean age of 39.9 ±13.82, TSH: 10.47 ±3.46, and serum calcium: 9.04 ±1.47. The mean age in our study was higher than the study by AlaEldin done in Sudan population, the mean TSH was found to be much lower while the serum calcium levels show elevated levels in our study in contrast to study by AlaEldin S. Ashmaik et al. CONCLUSION: This study presumed that in Telangana state, patients have low levels of serum calcium in hypothyroidism. S.Ca++ in hypothyroid people demonstrates a constructive connection between the S.Ca++ and serum TSH. These fluctuations of serum calcium ought to be considered in treating the patients with hypothyroidism by therapeutic experts. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Sameera_2016, title = {Sexing of hyoid bone based on shapes}, author = {Syeda Sadia Sameera and Syeda Nasreen Fatima and Gulam Mustafa Faisal}, url = {https://www.ijcap.org/article-details/2462}, doi = {10.5958/2394-2126.2016.00081.5}, issn = {2394-2118}, year = {2016}, date = {2016-09-01}, urldate = {2016-09-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {3}, pages = {355-360}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Introduction: The present study is to identify the sex of hyoid bone by studying various shapes of hyoid bone, and weight before and after defatting, were taken. Material: The material used in the present study includes 100 hyoid bones of adult male and female of 15-75 years of age group, procured from the cadavers brought to mortuaries for post mortem to Govt. General Hospitals of Hyderabad, and photographs of dried bone, to compare the shapes. Method: The bone was weighed with the help of chemical balance. The various shapes of the hyoid bone were noted and photographed individually and in groups. The readings were tabulated. Result: It was noticed that all the measurement were greater in males than in females. Males have mostly v shaped hyoid bone and females have mostly u shaped hyoid bone. Our findings co-related well with earlier workers, from diverse population groups. Conclusion: Data acquired by this study will contribute to the knowledge available about anthropometric parameters of South Indian population and may hopefully help in racial and medico-legal applications.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Anees_2016, title = {Acute phase reactants and lipid profile in acute chest pain presentations: a multimarker approach}, author = {Syyeda Anees and Jabeen Fatima and Mohammed Abbas Hyder}, url = {https://www.msjonline.org/index.php/ijrms/article/view/1131}, doi = {10.18203/2320-6012.ijrms20162290}, issn = {2320-6012}, year = {2016}, date = {2016-08-01}, urldate = {2016-01-01}, journal = {International Journal of Research in Medical Sciences}, volume = {4}, issue = {8}, pages = {3336--3342}, publisher = {Medip Academy}, abstract = {Background: Cardiovascular diseases cause more deaths and disability and incur greater economic cost than any other illness in the world. Our objective is to study the biological activity and evaluate the diagnostic and prognostic values of acute phase reactants, high sensitivity C-reactive protein (hsCRP) and ferritin in association with traditional lipid profile, in screening subjects who developed chest pain due to cardiac event as indicated by a positive cardiac troponin I (cTnI) test. Methods: In this hospital-based prospective study, a total of 150 cases (n=150), presented consecutively to the emergency department with symptoms of cardiac ischemia and tested positive for troponin I (enzyme-linked flourescent assay), were compared with an equal number of age and gender matched healthy controls (n=150) for hsCRP (immunoturbidimetric assay), ferritin (immunoturbidimetric assay) and lipid profile (enzymatic colorimetric assay). Results: Median serum hsCRP levels were 2.12 mg/L)±1.79 mg/L) than controls (2.82±significantly elevated in cases (3.57 (p0.05) different between the two groups. Conclusions: hsCRP and ferritin are independent novel predictors for cardiovascular risks and events. Lipid profile demonstrates low specificity in such cases.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Khan_2016c, title = {Rifampicin-induced interstitial nephritis: a case report and a short review of the literature}, author = {Ghouse Ahmed Khan and Fahad Abdullah Bin Breik and Yaseen Mohiuddin and S. V. Parathasaradhy and Mazharuddin Ali Khan and Ashfaq Hasan}, url = {https://jmas.in/fulltext/154-1463412038.pdf?1676966897}, doi = {10.5455/jmas.229206}, issn = {2231-1696}, year = {2016}, date = {2016-07-31}, urldate = {2016-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {6}, issue = {2}, pages = {84-86}, abstract = {Rifampicin induced acute interstitial nephritis (AIN) is a relatively rare entity, but in a setting of high tuberculosis (TB) prevalence, may be met with on occasion. TB is rife. If diagnosed and treated in time, the prognosis for renal recovery is good. We present such a case of a 42 year old woman who developed ATN after treatment with a rifampicin-based anti-tubercular regimen for TB synovitis of the wrist, nevertheless patient recovered after steriod therapy.}, keywords = {Nephrology, Orthopedics, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Karan_2016b, title = {Clinicopathological study of eyelid tumors in Hyderabad-a review of 57 cases}, author = {Siddharth Karan and Manisha Nathani and M. Tanveer Ali Khan and Sucheta Ireni and Aftab Abdul Khader}, url = {https://jmas.in/fulltext/154-1457890492.pdf?1693286501}, doi = {10.5455/jmas.221842}, issn = {2231-1696}, year = {2016}, date = {2016-07-31}, urldate = {2016-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {6}, issue = {2}, pages = {72-76}, abstract = {An eyelid tumor leads to functional and aesthetic problems. The preva-lence and distribution of eye lid tumors have considerable variation. The aim of this study was to categorize the prevalence and distribution of various eyelid tumors among population of Hyderabad over 3 years duration. This was a prospective study of 57 cases who reported to our tertiary hospital in Hyderabad from January 2013 to December 2015. The cases were analyzed for their sex distribution, tumor type, age distribution, incidence of malignant and benign tumors, tumor location, and complications at the time of presentation. The mean age of presentation of malignant tumors and benign tumors was 56 and 39 years respectively. The median age of presentation was 64 years for basal cell carcinoma, 50 years for sebaceous gland carcinoma (SGC) and 62 years for squamous cell carcinoma (SCC). The median age of presentation of various benign lesions were as follows: 33 years for dermoid cyst, 40 years for epidermal cyst, 36 years for capillary hemangioma, 54 years for squamous papilloma, 56 years for granulomatous lesion, 41 years for nevus, 19 years for keratoacanthoma, 58 years for sebaceous keratosis, 40 years for histiocytoma, 33 years for neurofibroma, 43 years for pleomorphic adenoma. The most common location of the tumor was upper lid (55.55%) for all the malignancies. Sebaceous gland carcinoma was the most common malignancy (55.5%) followed by basal cell carcinoma (33.3%) and squamous cell carcinoma (11.1%). Dermoid cyst was the most common type of benign lesion (37.5%). Surgical methods used were wedge excision with primary closure, wide excision, skin grafting and tarso-conjunctival flap. To conclude, sebaceous gland carcinoma was the most common malignancy and dermoid cyst was the most common tumor of benign origin. Hence it is our suggestion to have high degree of suspicion for these tumors for early diagnosis and intervention.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Chacham_2016, title = {Neonatal outcomes Rh-negative pregnancies in a tertiary level neonatal intensive care unit: a prospective study}, author = {Swathi Chacham and Diggireddy Shilpa Reddy and Uppin Narayan Reddy and Waseem Khan and Sreerambhatla Nandita and Soumya Anumula and Jakkampudi Nagasravani and Faraaz Adil}, url = {https://brieflands.com/articles/jcp-19862.pdf}, doi = {10.17795/compreped-36573}, issn = {2251-8150}, year = {2016}, date = {2016-07-24}, urldate = {2016-07-24}, journal = {Journal of Comprehensive Pediatrics}, volume = {7}, issue = {3}, pages = {e36573}, abstract = {Background: Rhesus incompatibility is a preventable cause for severe neonatal hyperbilirubinemia, hydrops fetalis and still births. The prevalence of the Rh-negative blood group among Indian woman varies from 2% - 10%. Despite declining the incidence of Rhesus incompatibility, due to availability of anti-D immunoglobulin, and improved antenatal care of the Rh-negative pregnant woman, it still accounts for a significant proportion of neonatal hyperbilirubinemia and neuro-morbidity. The prevalence of Rh-negative women having Rh-positive neonates is 60%. Objectives: This study aimed to estimate the incidence of Rh iso-immunization and evaluate the outcomes of Rh iso-immunized neonates. Methods: This prospective observational study was conducted in a tertiary level neonatal intensive care unit, Princess Esra hospital, Deccan college of medical sciences, Hyderabad, Telangana, India. Consecutive intramural and extramural neonates admitted to neonatal intensive care unit with the Rh-negative mother’s blood group and hyperbilirubinemia were enrolled. Neonates born to Rh+ve mothers were excluded. Neonatal gestational age, birth weight, age at admission, duration of phototherapy, duration of hospitalization, neonatal examination and investigations were recorded in a predesigned, pretested performa. Results: A total of 90 neonates were born to Rh-negative mothers, of which 70% (63) had the Rh-positive blood group and 30% had the Rh-negative blood group. Of these 63 neonates, 48 (76.2%) had hyperbilirubinemia and 43 neonates (68.3%) had significant hyperbilirubinemia (total serum bilirubin > 15mg/dL). Among them, 2%, 75% and 23% were born to primi, multi and grandmutli, respectively. Also, 14.5% of the neonates were large for dates (LFD), 75% appropriate for dates (AFD) and 10.5% were small for dates (SFD). Premature and SFD neonates had higher incidence of hyperbilirubinemia. Significantly higher incidence of jaundice occurred within 72 hours of life. The mean serum bilirubin level among neonates with significant hyperbilirubinemia was 17.98 ± 1.76 (95% CI:17.43 - 18.52) while that of neonates without significant hyperbilirubinemia was 13.1 ± 0.53 (95% CI:12.47 - 13.77) with statistical significance (P < 0.0001). Maternal multiparity, direct coombs test (DCT) positivity, and abnormal neurosonogram (NSG) were important accompaniments of high serum bilirubin levels. Conclusions: Incidence of Rh-positive phenotype in neonates born to Rh-negative mothers is 70%. Incidence of hyperbilirubinemia among them is 76.2% and that of significant hyperbilirubinemia was 68.3%. The incidence of DCT positivity was 20.9%. Maternal multiparity, positive DCT and abnormal NSG were important associates of high serum bilirubin levels.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Naseem_2016c, title = {Accidental poisoning its magnitude and implications in children}, author = {Altaf Naseem and Mir Sumsam Ali Khurram and Sana Salim Khan and Nizar Lalani}, url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/127/250}, doi = {1 0.17511/ijpr.2016.i06.06}, issn = {2349-3267}, year = {2016}, date = {2016-06-30}, urldate = {2016-06-30}, journal = {Pediatric Review: International Journal of Pediatric Research }, volume = {3}, issue = {6}, pages = {400-409}, abstract = {Background: Paucity of data due to under reporting of accidental poisoning (AP) poses obstacle in assessing the trend, incidence, and mortality in pediatric population. Objective: Estimating the magnitude and assessing the pattern of AP in children was the primary objective. Describing the affected age group, common agents and assessment of clinical features were the secondary objectives. Materials & Methods: Children aged 1month- 12years with history of AP were included; those with allergic reactions to plant products, food and idiosyncratic reactions to drugs were excluded. Result: 101 children accounted for 1.7% of total pediatric admission. Accidental ingestion of poisons (90.09%) and poisoning due to insect and snake bites (9.90%) were reported. Males (n=62) outnumbered females. Patients from urban area (68.2%), children aged 1-3 years (56.43%) were affected the most. All incidents were unintentional and occured in the home surroundings. April (n=21), March (n=20) recorded higher number followed by December (n=14). Hydrocarbon poisoning (43.56%) was most common followed by poisoning due to medicaments (18.8 %,), chemicals (12.87%), and food poisoning (9.90%). Insect bites & stings were seen in 9.90% Supportive treatment was given to 49.5%, further gastric absorption prevented in 24.45 % and specific antidote to 7.9% patients. Three patients died due to scorpion bite, Phenytoin and kerosene ingestion. Conclusion: AP is a preventable emergency. Incidence, agents, clinical features, treatment administered and therapeutic outcome of AP in children are comparable to the available national data. Preventive measures, strict legislative actions and restriction of availability of hazardous chemicals will reduce the incidence. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Sayeed_2016, title = {Effect of testosterone and estrogen ratio-An indicator of benign prostatic hyperplasia (BPH)}, author = {Qhurrathul Ain Sayeed and Farisa Khatoon and Farah Bahmed and Maria Kaleem}, url = {https://www.ijcap.org/article-details/1883}, doi = {10.5958/2394-2126.2016.00030.x}, issn = {2394-2118}, year = {2016}, date = {2016-06-30}, urldate = {2016-01-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {2}, pages = {125-130}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Background: Benign prostatic hyperplasia (BPH) is one of the most common disease and major cause of morbidity in elderly men. Prostatomegaly often used interchangeably with BPH, is a prominent feature of the disease. Although sex steroid hormones play a vital role in prostate growth, their clinical significance is not completely clear. The phenomenon may be correlated with changes of sex hormone in serum of elderly population. Hence, the objective of this study was to study the roles of serum hormones levels – Testosterone (T) and Estradiol (E2) in elderly patients aged 60-75 years who are diagnosed with benign prostatic hyperplasia (BPH) and to understand the correlation between T/E2 ratio over age as markers of prostate disease. Methods: To conduct this case control study, a population of 30 patients with benign prostatic hyperplasia (BPH) had been selected and 30 well-matched males without BPH as a control group. Result: Testosterone level declined with age, but serum estrogens level remains unaltered so estrogen may be involved in the development of BPH. Conclusion: The present study suggests that testosterone estrogen ratio can be an indicator of BPH in patients above 45 years of age.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2016, title = {Visual evoked potential as an early marker of diabetic retinopathy}, author = {Farisa Khatoon and Farah Bahmed and Nazeema Khatoon}, url = {https://www.ijcap.org/article-details/1899}, doi = {10.5958/2394-2126.2016.00046.3}, issn = {2394-2118}, year = {2016}, date = {2016-06-30}, urldate = {2016-01-01}, journal = {Indian Journal of Clinical Anatomy and Physiology}, volume = {3}, issue = {2}, pages = {200-204}, publisher = {IP Innovative Publication Pvt. Ltd.}, abstract = {Background: Chronic hyperglycemia in diabetes mellitus causes damage to various organs, particularly eyes, kidneys, nerves, heart, and the blood vessels. Visual defects in diabetics occurs due to both vascular and metabolic abnormalities which can affect retina, optic nerve and visual pathway. Change in Visual evoked potential (VEP) response occurs in diabetic patients much earlier than development of overt retinopathy and these changes correlate with duration of disease. Aim of this study was to determine the subtle functional changes in the retina of diabetic eye with the help of VEP before diabetic retinopathy sets in. In the current study comparison between amplitudes, latency P100 of VEP in type 2 diabetes mellitus with that of healthy controls was done. Method: Cross sectional study using 100 controls and 100 diabetic patients was carried out in the department of Physiology Deccan college of Medical Sciences, Hyderabad. Statistical analysis was done using SPSS software. Result: Significant association was obtained between duration of diabetes mellitus and P100 latency. Conclusion: VEP can be used as a very useful electrophysiological indicator of early subtle functional changes of retina in diabetes mellitus.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Gurrala_2016, title = {Myeloperoxidase variants (at SNP-463 G/A) and the risk of coronary artery disease: a case control study}, author = {Rajashekar Reddy Gurrala and K. Laxman Rao and Vinod K. Unni and Parvaiz Kadloor and Nausheen Fatima and Parveen Naimath and Mohammed Ishaq}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/June_2016_1466490696__109.pdf}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2016}, date = {2016-06-30}, urldate = {2016-06-30}, journal = {Indian Journal of Applied Research}, volume = {6}, issue = {6}, pages = {334-335}, abstract = {The aim of the study was to evaluate the role of single nucleotide polymorphism (SNP) at -463 G/A position by PCR in predisposition to coronary artery disease. A total of 69 CAD patients to an equal number of healthy subjects were included in the study. The frequency of AA genotype in patients was 1.44% compared to 5.79% in healthy controls. Odd ratio analysis revealed a OR=0.24 indicating that persons with AA genotypes have about 76% reduced risk of CAD.}, keywords = {Cardiology, Central Research Laboratory}, pubstate = {published}, tppubtype = {article} } @article{Raheem_2016, title = {Comparative analysis of serum malondialdehyde levels as a marker of oxidation stress in acute myocardial infarction cases with and without T2DM}, author = {M. A. Raheem and Mohammed Siraj and Rajashekar Reddy Gurrala and Syed Azhar Ali and Priyanka T. N. and Mohammed Ishaq}, url = {https://www.journalijar.com/uploads/460_IJAR-10867.pdf}, issn = {2320-5407}, year = {2016}, date = {2016-06-30}, urldate = {2016-06-30}, journal = {International Journal of Advanced Research}, volume = {4}, issue = {6}, pages = {1270-1272}, abstract = {Oxidative stress is considered as one of the important mechanism in the causation of type 2 diabetes (T2DM) as well as cardiovascular diseases. Quantification of serum malondialdehyde (MDA) is generally employed as reliable marker of assessment of oxidative stress. The objective of the present study was to estimate serum MDA levels in acute myocardial infarction cases with and without T2DM. A total of 60 AMI patients were studied, including 30 cases of AMI with T2DM and an equal number of cases of AMI without T2DM. Mean serum levels of MDA were 543.17± 56.97 and 423.50 ± 51.12 nmol/dL respectively in cases of AMI with T2DM and those without T2DM (p<0.05). Significantly elevated levels of serum MDA were observed in T2DM cases with AMI than those without T2DM. Significance of the results has been discussed in terms of age at onset as well as severity of AMI. }, keywords = {Cardiology, Central Research Laboratory, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Mahmood_2016, title = {Proteins, lactate dehydrogenase and adenosine deaminase in pleural fluid- useful markers in differentiating tuberculosis from lung cancer}, author = {Shaikh Mahmood and Syyeda Anees and Badruz Zama and Mohammed Abbas Hyder}, url = {http://journalcmpr.com/sites/default/files/issue-files/0145.pdf}, issn = {2395-6429}, year = {2016}, date = {2016-06-20}, urldate = {2016-06-20}, journal = {International Journal of Current Medical and Pharmaceutical Research}, volume = {6}, issue = {1}, pages = {356-360}, abstract = {To evaluate the clinical and laboratory characteristics of pleural effusions in to tuberculosis (TB) or cancer (CA). A total of 385 patients with pleural effusion due to TB (n=175) or CA (n=112) were studied. The following parameters were analyzed: patient gender, age and pleural effusion characteristics (size, location, microscopic fluid aspect protein concentration, lactate dehydrogenase (DHL) and adenosine deaminase activity (ADA) and nucleated cell counts). The objective of this study was to evaluate the utility of the determination of protein concentration, lactate dehydrogenase (DHL) and adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE). We retrospect tively reviewed the clinical records of 385 patients with pleural effusion and investigated their pleural protein concentration, DHL and ADA levels as determined by an auto analyzer (Micro Lab 300). The study included patients with TPE (n＝175), MPE (n＝112), benign non-tuberculous pleural effusion (n＝81), and pleural effusion of unknown etiology (n＝17). Although the protien concentration, DHL and ADA activity in pleural fluid can help in the diagnosis of TPE and MPE patients. Fluid with higher protein (p < 0.001) levels predominated in effusions from the tuberculosis group (5.3 + 0.8 g/dL) when compared to the CA group (4.2 ± 1.0 g/dL), whereas DHL levels were more elevated in CA (1,177 ± 675 x 1,030 ± 788 IU; p = 0.003) than in TB. As expected, ADA activity was higher in the TB group (107.6 ± 44.2 X 30.6 ± 57.5 U/L; p < 0.001). Our results demonstrate that in lymphocytic pleural exudate obtained from patients with clinical and radiological evidence of tuberculosis, protein concentration, DHL and ADA were the parameters that better characterize these effusions. In the same way, when the clinical suspicion is malignancy, serous- hemorrhagic lymphocytic fluid should be submitted to oncotic cytology once this easy and inexpensive exam reaches a high diagnostic performance ( 80%). In this context, we suggest thoracocentesis with fluid biochemical and cytological examination as the first diagnostic approach for these patients.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Haneef_2016b, title = {Pattern of patch test positivity in chronic urticaria patients in a tertiary care hospital in Telangana}, author = {Nayeem Sadath Haneef}, url = {https://www.jebmh.com/articles/pattern-of-patch-test-allergen-positivity-in-chronic-urticaria-patients-in-a-tertiary-care-hospital-in-telangana.pdf.pdf}, doi = {10.18410/jebmh/2016/524}, issn = {2349-2562}, year = {2016}, date = {2016-06-13}, urldate = {2016-06-13}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {47}, pages = {2380-2384}, abstract = {CONTEXT: Patch test is the gold standard for detection of causative allergens in allergic contact dermatitis. Though chronic urticaria is a multifactorial condition, a sizeable number of such patients are thought to be due to various contact allergens. Hence, a hospital based prospective study of patch test positivity to various allergens was conducted in patients suffering from chronic urticaria. AIMS: To evaluate the pattern of allergen positivity in chronic urticaria patients by patch test using Indian Standard Series. SETTINGS & DESIGN: Prospective investigational study was conducted at Dermatology, Venereology and Leprosy department of a tertiary care hospital attached to a postgraduate training institute in Telangana state of India. METHODS & MATERIAL: Thirty chronic urticaria patients, above 18 years of age were evaluated with patch test of Indian standard series. Two of these patients had prior history of contact sensitivity to rubber and paraphenylenediamine. Patch test was done by application of allergens of Indian standard series over upper back. Patch test site was examined after 48 hours and after 72 hours. Patch test was considered positive if erythema, erythematous papules or vesicles were found at the site of application of corresponding allergen. RESULTS: Patch test was positive in 4 out of 30 patients of chronic urticaria, fragrance, black rubber mix, paraphenylenediamine and parthenium being the allergens in 1 patient each. Patients with positive patch test to black rubber mix and paraphenylenediamine had prior history of contact allergy. CONCLUSION: Patch test is a simple, noninvasive, inexpensive and useful diagnostic test in a difficult to evaluate condition of chronic urticaria, irrespective of feasibility of avoidance of potential allergens. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Nori_2016, title = {Fetal MR imaging analysis of sirenomelia with clinico radiographic correlation: a case report}, author = {Madhavi Nori and G. Raghavendra Prasad and Arvind K. Reddy and Sandeep Reddy Cheguri}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963740/pdf/jcdr-10-TD08.pdf}, doi = { 10.7860/JCDR/2016/19117.8057}, issn = {0973-709X}, year = {2016}, date = {2016-06-01}, urldate = {2016-06-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {10}, issue = {6}, pages = {TD08-TD10}, abstract = {Sirenomelia is a social curiosity, a medical and diagnostic challenge prenatally compounded by varied diagnostic difficulties. Prenatal diagnosis of sirenomelia was and continues to be a challenge although von klippel et al., described a case at 10 weeks of gestational age. However, they needed a second imaging at 12(th) week for confirmation. First trimester or early second trimester anatomic survey on ultrasound and MRI is accurate for the diagnosis thereby avoiding unnecessary complex pregnancy. We report a case of second trimester diagnosed sirenomelia, with detailed analysis of image findings on ultrasound and fetal MRI. }, keywords = {Pediatric Surgery, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2016, title = { A study on efficacy of intra-nasal midazolam spray in seizure patients: a prospective study}, author = {B. Sugunakar Reddy and Uppin Narayan Reddy and Mohd. Nasir Mohiuddin and Altaf Naseem and Mir Sumsam Ali Khurram and Javed Ullah and Ozlem Kaya}, url = {http://innovativejournal.in/index.php/ijmhs/article/view/1060/pdf_97}, doi = {10.15520/ijmhs.2016.vol6.iss3.120}, issn = {2277-4939}, year = {2016}, date = {2016-06-01}, urldate = {2016-06-01}, journal = {Innovative Journal of Medical and Health Science}, volume = {6}, issue = {3}, pages = {98-100}, abstract = {An epileptic seizure is brief episodes of abnormal excessive or synchronous neuronal activity in the brain. The effect varies from uncontrolled jerking movements to momentary loss of awareness. The syndrome of recurrent and provoked seizures is termed epilepsy, but seizures can also occur in people who don’t have epilepsy it may vary on the patient’s genetic susceptibility.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Naseem_2016d, title = {Impact of iron deficiency on cognitive functions and effect of iron supplements in children between 5-10 years: Indian perspective}, author = {Altaf Naseem and Mir Sumsam Ali Khurram and Nizar Lalani}, url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/111/218}, doi = {10.17511/ij pr.2016.i05.08}, issn = {2349-3267}, year = {2016}, date = {2016-05-31}, urldate = {2016-05-31}, journal = {Pediatric Review: International Journal of Pediatric Research}, volume = {3}, issue = {5}, pages = {313-322}, abstract = {Background: Data on iron deficiency anemia (IDA) and cognitive function in Indian children aged 5-10 years is limited. Objective: To study the extent of IDA, its impact on cognition and evaluate the effect of iron supplementation on cognitive function in children with IDA. Methods: Children aged 5-10 years (n=193) were grouped into overt (group I n=71 ,Ia- received iron supplements, Ib –without iron supplement), latent (group II, n=48, IIa- received iron supplements, IIb –without iron supplement)) anemia and non anemia (Group III, n=74) categories. Basic hematological investigations (HB, MCV, peripheral smear and total iron binding capacity) were done at baseline to categorize into groups. Cognitive function tests were performed at baseline and at the end of the study. Deworming with broad spectrum anthelmintic agent Albendazole (400mg stat) followed by iron supplements for 3 months was administered to Group Ia and IIa children. Results: Of 193 children, 119 (61.65%) had Iron deficiency, seventy (36.27%) had overt anemia and 49(25.397%) had latent form. Mean±SD Haemoglobin at baseline was 11.80±1.71gm/dL, MCV 82.07±4.69 femolitres, TIBC was 403.58 ± 58.77μ g/dL. Cognitive functions were significantly (p<0.005) higher in non anemic children. Iron supplements were administered for 3 months to 58 students. Treatment compliance was 96.0%. Hemoglobin>12gms/dL was seen in 80.83% (156/193) had <12 gms/dL, after iron supplements; Mean ± SD Haemoglobin was 12.76±1.39gm/dL and that of visual recall, digit span and clerical task changed from 5.63±1.08, 4.03±1.0, and 7.16±1.4, respectively to 6.34±0.82, 4.35±0.78 And 7.98±1.19 respectively. Higher scores were seen in those with haemoglobin>12 gms/dL.Conclusion: Non anemic children perform better than those with anemia; performance of those with latent anemia is better than those with overt anemia. Iron supplementation helps in improved performance in these children. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2016, title = {Knowledge and attitudes of anganwadi workers about breast feeding in the field practice area of tertiary care hospital, Hyderabad}, author = {Sultan Rizwan Ahmad and Mohammad Abdul Thaher and A. Chandrasekhar}, url = {https://njcmindia.com/index.php/file/article/view/965/743}, issn = {0976-3325}, year = {2016}, date = {2016-05-31}, urldate = {2016-05-31}, journal = {National Journal of Community Medicine}, volume = {7}, issue = {5}, pages = {413-416}, abstract = {Background: Breast feeding is one of the most important determinants of child survival, birth spacing and prevention of childhood infections. It is important for the Anganwadi workers to have adequate scientific knowledge about breast feeding practices. . Hence this study was conducted to assess the knowledge and attitude of AWW with regards to breast feeding practices. Methodology: A facility based cross sectional study was conducted covering all 68 ICDS centers. A pretested semi-structured questioner was given to all AWWs. All questions were read out and explained by the author and all queries were clarified. Results: only 70 % AWW believed that breast feeding should be given on demand and 75 % AWWs believed that bottle is better than katori & spoon for infant feeding. 40% said breastfeeding should be stopped if mother is sick. Most of AWW (98%) believed that almonds and dry fruits increase breast milk secretion. Conclusion: Present research draws very important conclusions that although knowledge of AWW regarding initiation of breast feeding is high but their knowledge regarding prelecteal feeds, feeding on demand, bottle feeding and breast feeding during sickness needs further improvement.}, keywords = {}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2016b, title = {Knowledge, attitude and practice regarding smoking among medical students}, author = {Sultan Rizwan Ahmad and Mohammad Abdul Thaher and A. Chandrasekhar}, url = {https://publichealth.medresearch.in/index.php/ijphr/article/view/38/55}, doi = {10.17511/ijphr.2016.i3.02}, issn = {2349-4158}, year = {2016}, date = {2016-05-22}, urldate = {2016-05-22}, journal = {Public Health Review: International Journal of Public Health Research}, volume = {3}, issue = {3}, pages = {96-101}, abstract = {Background: Tobacco smoking is a risk factor for many disease and cancers and one of the leading causes of death. Smoking is rampant among medical students all over the world. This study has been aimed at studying the knowledge, attitude and practice regarding smoking and awareness of smoking related legislation among medical students. Materials and Methods: A cross sectional study was carried out among the medical students in a Medical college. All students given consent were interviewed using a pre-designed and pretested questionnaire at a convenient time. Study and confidentiality aspects were explained to the students. Data were collected regarding knowledge, attitude and practice of smoking. Results: Prevalence of smoking was 18% among male students and nil among female students. Mean age of starting smoking was 18 years. 68% were daily smoker, and smoke 10 or fewer cigarettes daily. 44% got influenced by friends in initiating smoking. 63% smoker have smoker in friends or family. 36% of smokers have habit of alcohol consumption associated with smoking. 32% did not aware of legislation related to smoking. 20% students are aware that smoking is banned in educational institution. Conclusion: Students are trying to quite the smoking, support from friends and family could contribute significantly in helping them. Awareness regarding legislation related to smoking should be incorporated in students counseling activities.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Karan_2016, title = {A non randomised prospective study of thyroid orbitopathy in tertiary care centre}, author = {Siddharth Karan and Manisha Nathani and M. Tanveer Ali Khan and Aftab Abdul Khader and Sucheta Ireni and Abdul Basith Syed}, url = {https://www.jebmh.com/articles/a-nonrandomised-prospective-study-of-thyroid-orbitopathy-in-a-tertiary-care-centre.pdf.pdf}, doi = {10.18410/jebmh/2016/425}, issn = {2349-2562}, year = {2016}, date = {2016-05-12}, urldate = {2016-05-12}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {38}, pages = {1910-1914}, abstract = {Graves’ disease is an autoimmune condition where TSH receptors are targeted by the auto-antibodies. Although most patients have clinical or laboratory evidence, the disease process can occur even in the absence of detectable thyroid abnormality. Although most cases of TAO can be managed medically without any visual loss, it may result in exposure keratitis and compressive optic neuropathy. There was female preponderance noted. Maximum number of patients were in the 25-50 years of age group. More than 65% of the patients were hyperthyroid followed by euthyroid in 25% and then hypothyroid in less than ten percent. In both the sexes, the hyperthyroid status was the most common followed by euthyroid and hypothyroid. No male was reported to be hypothyroid. The most common presentation was found to be bilateral than unilateral. Inferior rectus was the commonest muscle involved followed by medial rectus, superior rectus-LPS complex and lateral rectus in descending order. Incidence and various modes of presentation of ‘Thyroid Orbitopathy’ of our study at our tertiary centre in Hyderabad are correlating with national and international studies. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Haneef_2016, title = {A clinical observational study of orocutaneous manifestations in people living with HIV/AIDS}, author = {Nayeem Sadath Haneef}, url = {https://www.jemds.com/data_pdf/1_Nayeem.pdf}, doi = {10.14260/jemds/2016/479}, issn = {2278-4748}, year = {2016}, date = {2016-05-02}, urldate = {2016-05-02}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {5}, issue = {35}, pages = {2042-2048}, abstract = {CONTEXT: India has third highest prevalence of HIV/AIDS patients in the world. There were an estimated 2.31 million (1.8-2.9 million) people living with HIV/AIDS (PLHA) in India in 2007, whereas, slightly declining to 2.1 million in 2013. Early diagnosis of this infection is important not only for effective treatment of the affected patient but also for prevention of further transmission to others. Cutaneous manifestations can be an early pointer to this infection and hence play an important role in the control of HIV/AIDS. They are also useful for clinical staging (WHO staging) of these patients for therapeutic and prognostic purposes, especially in the absence of sophisticated laboratory facilities, as in many parts of India. The profile of cutaneous manifestations in HIV/AIDS patients varies according to their CD4 count. Some of these manifestations are also unique to certain geographic areas. AIMS: To study the local pattern of cutaneous and oral manifestations in people living with HIV/AIDS. SETTINGS AND DESIGN: A clinical, observational study was conducted among patients consulting Dermatology, Venereology and Leprosy Department of a Tertiary Care, Medical College Hospital in Telangana State, South India. METHODS AND MATERIAL: A total of 120 patients of HIV/AIDS, detected by ELISA or other tests, belonging to all age groups and sexes were included. RESULTS: Most common cutaneous manifestations observed were pruritic papular rash (20.8%), scabies (12.5%), folliculitis (11.7%), dermatophytosis (10.8%), xerosis (10.8%), seborrhoeic dermatitis (10%), drug rashes (9.2%), candidal vaginitis (5%), molluscum contagiosum (4.2%), and herpes genitalis (3.3%). Oral candidiasis was the commonest oral mucosal manifestation (37.5%). CONCLUSION: Most of the cutaneous and oral manifestations found in PLHA were concurrent with previous studies, but high incidence of pruritic papular rash is an interesting finding of this study.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2016b, title = {Observational study on the prevalence of diabetes mellitus among ultrasonographically diagnosed cholelithiasis patients}, author = {Mohammed Abdul Hannan Hazari and Shadan Taskeen and Mehnaaz Sameera Arifuddin}, url = {https://www.ijcep.org/index.php/ijcep/article/view/264}, doi = {10.4103/2348-8093.185206}, issn = {2348-8093}, year = {2016}, date = {2016-04-30}, urldate = {2016-01-01}, journal = {International Journal of Clinical and Experimental Physiology}, volume = {3}, issue = {2}, pages = {77-81}, publisher = {EManuscript Technologies}, abstract = {Background and Aim: Diabetes and cholelithiasis are common diseases worldwide in this era of modern epidemics of non - communicable diseases. Studies revealed that diabetes is a risk factor for gallstones. Since both diseases are related to altered carbohydrate and lipid metabolism, we hypothesized that the vice‑versa, i.e., gallstone disease can be a risk factor for the development of diabetes. The aim of this study was to find the prevalence of diabetes mellitus among ultrasonographically diagnosed cholelithiasis patients and to find any correlation between parameters of gallstones and diabetes mellitus. Methods: This was a hospital‑based observational study. A total of 31 gallstone patients belonging to both genders (male = 9, female = 22) and in the age group of 20–80 years were enrolled in the study. From ultrasound report, parameters noted were: size of gallbladder, solitary or multiple gallstones, and size of the largest gallstone. All patients were asked about history of diabetes mellitus, (if history of diabetes is present – whether the diabetes was diagnosed before or after cholelithiasis), monthly family income, education status, and occupation. Data obtained were subjected to appropriate statistical analysis. P < 0.05 was considered statistically significant. Results: In this endeavor, we found that the prevalence of diabetes among cholelithiasis patients was only 35.48%; and of the 11 diabetic patients, 3 developed gallstones before the diagnosis of diabetes mellitus. Socioeconomic status did not have any bearing on the occurrence of diabetes and gallstones in our patients. Glycated hemoglobin levels did not correlate with the severity of gallstone disease which is assessed in the form of solitary/multiple stones and size of the largest gallstone. Conclusion: There is no increased prevalence of diabetes among cholelithiasis patients. Our hypothesis of gallstones acting as risk for developing diabetes could not be proved.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Pasha_2016b, title = {Magnesium supplementation: is this a miracle drug to control diabetes-induced abnormal lipid profile}, author = {Ather Akhtar Pasha and Suhail Bin Ahmed}, url = {https://www.jebmh.com/articles/magnesium-supplementation-is-this-a-miracle-drug-to-control-diabetesinduced-abnormal-lipid-profile.pdf.pdf}, doi = {10.18410/jebmh/2016/376}, issn = {2349-2562}, year = {2016}, date = {2016-04-30}, urldate = {2016-04-30}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {35}, pages = {1679-1682}, abstract = {BACKGROUND: Reduced levels of magnesium levels have been observed in adults who have diabetes mellitus. It was also observed in children who were supposed to have good nutritional status but were diagnosed diabetic. Low levels of serum magnesium have been linked to a number of complications that is observed in diabetes mellitus. Reduced tyrosine kinase activity has been observed. This may result in reduced insulin sensitivity. The low levels of serum magnesium may be due to glycosuria-related hypermagnesiuria, nutritional factors or hyperinsulinaemia. Diabetic patients often have disturabances of their lipid profile. Magnesium supplementation is known to have a benificial effect on the lipid profile. The aim of the study is to find whether magnesium supplementation improves the lipid profile of the diabetic patients or not. METHOD: The study is a cross-sectional study and the study is multi-staged. The age criteria was not taken into consideration since all the patients belonged to the age group of 40 to 60 years. Inclusion Criteria: 1. The patients were atleast known diabetics since one year. 2. Patients were aged between 40 to 60 years. 3. Patients who were ready to be a part of this study and would come back for followup. Exclusion Criteria: 1. Patients who were known to have diabetic renal complications. 2. Patients who were on dialysis. 3. Patients who were on diuretics. 4. Patients who took magnesium antacids. RESULT: The principle finding of this study is that the serum magnesium level is inversely related to the HbA1c, serum cholesterol, LDL and triglycerides. It is directly proportional to the HDL levels. Magnesium is known to play an important role in carbohydrate metabolism, and its imbalance has been implicated in diabetes mellitus both as a cause and a consequence. CONCLUSION: There is a lot of scope for this study since it is slowly being understood that diabetes is not a single disease but a plethora of diseases whose dimensions are slowly being uprooted. Indeed magnesium supplementation improved the lipid profile and in the coming days it would be called a miracle drug with vast potentials. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Pasha_2016, title = {Clinical profile of anaemia in a tertiary care hospital}, author = {Ather Akhtar Pasha and Suhail Bin Ahmed}, url = {https://www.jebmh.com/articles/clinical-profile-of-anaemia-in-a-tertiary-care-hospital.pdf.pdf}, doi = {10.18410/jebmh/2016/356}, issn = {2349-2562}, year = {2016}, date = {2016-04-25}, urldate = {2016-04-25}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {33}, pages = {1586-1589}, abstract = {BACKGROUND: Anaemia causes a reduction in the oxygen carrying capacity of the blood resulting in tissue hypoxia. Cardiac output at rest is not usually increased in most chronic anaemia until haemoglobin levels fall below 7 g/dL, but abnormal rise in output with exercise may occur with levels as high as 10 g/dL. The increase in cardiac output has been observed to correlate well with the degree of anaemia. Other compensatory mechanisms to chronic anaemia available to the body include decreased circulation time and increased tissue oxygen uptake. The latter is facilitated by a shift to the right of the oxygen haemoglobin dissociation curve. Cardiomegaly may also be as a result of the increased workload on the heart from the increased viscosity of blood in anaemia patients. Anaemia in the elderly is an extremely common problem that is associated with increased mortality and poorer health-related quality of life, regardless of the underlying cause of the low haemoglobin. A study of anaemia in elderly patients found a wide variation in prevalence, ranging from 2.9% to 61% in men and 3.3% to 41% in women. Higher rates were found in hospitalised patients than in community dwellers. It is easy to overlook anaemia in the elderly, since such symptoms as fatigue, weakness, or shortness of breath may be attributed to the ageing process itself. Our objective is to show the prevalence of anaemia even in a tertiary health care centre. METHODS: One hundred patients were identified who were admitted in the Department of Medicine, Deccan College of Medical Sciences. Among the 100 patients, 38 were male and 62 were female. The study was conducted from Jan 2014 To Jan 2015. Patients having haemoglobin less than 10 g% in the medical wards were enrolled in the study. RESULTS: Among the 100 patients, 38 were male and 62 were female. The average haemoglobin was 6.4 g%, the lowest being 2.8 g%. Peripheral blood smear showed hypochromic picture in 58, macrocytic picture in 22 and the morphology was normocytic normochromic in 20 cases. Tuberculosis leading to anaemia was seen in 24, Internal haemorrhoids/Fissures 5, Taenia infestation in 3, Haematological Malignancies 2, GI Malignancies 3, Connective tissues disorders 3, Nutritional iron deficiency 8 and Anaemia of chronic diseases in remaining cases. Among the 22 cases having macrocytic anaemia, 11 had vitamin B 12 deficiency, 6 had subclinical hypothyroidism, 5 had alcoholism. Among the 20 patients having normocytic normochromic blood picture, 4 had haemolytic anaemia, 1 had aplastic anaemia and remaining were having anaemia of chronic disease mainly chronic kidney disease. Regarding treatment, 23 patients were transfused blood. Out of total 100 patients included in the study, in-hospital mortality was 10. CONCLUSIONS: Anaemia is associated with a variety of diseases. As Tuberculosis and B 12 Deficiency are among the leading causes of anaemia, hypochromic and microcytic picture was the predominant picture in peripheral blood smear. Among the patients having normocytic normochromic blood picture, majority were having chronic kidney disease which may be due to the fact that our hospital is a tertiary referral centre for chronic renal failure. In-hospital mortality due to anaemia alone is lower in tertiary care centres, but the mortality in our study is due to associated comorbid conditions like chronic renal failure and malignancy. }, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Bardia_2016, title = {Genetic polymorphisms of X-ray repair cross-complementing group 1 and Apurinic/Apyrimidinic endonuclease-1 in chronic obstructive pulmonary disease}, author = {Avinash Bardia and Sandeep Kumar Vishwakarma and Chandrakala Lakki Reddy and N. Raju and Shaik Iqbal and Gallapalli Sravani and Narneni Lavanya and Nazima Begum and Nazia Uzma and Pratibha Nallari and Badruz Zama and Syed Mahmood Ahmed and Ashfaq Hasan and Aleem Ahmed Khan}, url = {https://link.springer.com/article/10.1007/s10753-016-0355-x}, doi = {10.1007/s10753-016-0355-x}, issn = {0360-3997}, year = {2016}, date = {2016-04-23}, urldate = {2016-04-23}, journal = {Inflammation}, volume = {39}, issue = {3}, pages = {1198–1204}, abstract = {Chronic obstructive pulmonary disease (COPD) is a heterogeneous collection of conditions characterized by irreversible expiratory airflow limitation. The disease is interspersed with exacerbations; periods of acute symptomatic, physiological, and functional deterioration. The present study was designed to investigate the role of X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1) polymorphisms and the risk of COPD. Blood samples from 354 unrelated subject (age range 18–60 years; 156 with COPD, 198 healthy controls) were collected. Genomic DNA was isolated and genotyped for XRCC1 Arg399Gln and APE1 Asp148Glu using a confronting two pair primers polymerase chain reaction. GA genotype of XRCC1 gene was found to be predominant in the COPD group compared to controls with 1.86-fold increased risk for COPD (OR 1.86, 95 % CI 1.20–2.88, p = 0.0013). TG genotype of APE1 was found to be predominant in COPD group compared to controls with the difference being statistically significant (OR 1.68, 95 % CI 1.08–2.61, p = 0.0043). The GA haplotype was found to be predominant in COPD than controls with a 2.19-fold significant increase (OR 2.19, 95 % CI 1.46–3.28, p = 0.003). Polymorphism in XRCC1 and APE1 gene is associated with an increased risk of COPD.}, keywords = {Biochemistry, Central Research Laboratory, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Rozati_2016b, title = {Role of anti-mullerian hormone in women with polycystic ovarian syndrome on metformin therapy}, author = {Roya Rozatti and Surayya Tahseen and Akhila Reddy and Nazima Allaudin and Fatima Tahniyath and Fatima Hafeez and A. G. Mehdi}, url = {https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_3_march_issue_3/1456733725.pdf}, issn = {2349-8870}, year = {2016}, date = {2016-03-31}, urldate = {2016-03-31}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {3}, issue = {3}, pages = {180-183}, abstract = {Background: AMH production by granulosa cells in the polycystic ovary is 2-3 fold increase compared to healthy women. Purpose of the study: Anti-Mullerian hormone (AMH) is produced by the granulosa cells surrounding prenatal and antral follicles and has an important role in the development and maturation of follicles. Several studies have suggested that AMH serum levels may be a marker for polycystic ovary syndrome (PCOS). Methods: Prospective study was conducted in the Department of Obstetrics and Gynaecology, Owaisi Hospital and Research Centre and Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad from March 2014- April 2015. Results: A total of 34 patients diagnosed cases of PCOS. Mean serum Anti Mullerian hormone levels were significantly decreased in PCOS population on metformin therapy as compared to PCOS population not on metformin therapy. Conclusion : Serum AMH is a useful prognostic biochemical marker for metformin therapy in PCOS. }, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Rozati_2016c, title = {The impact of body mass index in pregnant women and their obstetric outcomes in a tertiary care hospital of South India from August 2013-2015}, author = {Roya Rozati and Akhila Reddy and Surayya Tahseen and Nazima Allaudin and Fatima Tahniyath and Fatima Hafeez and A. G. Mehdi}, url = {https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_3_march_issue_3/1456731137.pdf}, issn = {2349-8870}, year = {2016}, date = {2016-03-31}, urldate = {2016-03-31}, journal = {European Journal of Biomedical and Pharmaceutical Sciences}, volume = {3}, issue = {3}, pages = {173-179}, abstract = {OBJECTIVE To assess the prevalence of overweight and obesity, and the impact of body mass index (BMI) on maternal and neonatal outcomes, in a UK obstetric population. STUDY DESIGN: A retrospective study was conducted and data was collected from births between August 2013 to August 2015 within a tertiary referral unit, with over 3600 births per year. STUDY PERIOD: August 2013 – August 2015 STUDY SITE: This study was carried out in OWAISI HOSPITAL AND RESEARCH CENTRE as a clinical audit and therefore did not require approval from a Research Ethics Committee. Women were categorised according to World Health Organization classification: underweight (BMI < 18.50 kg/m2); normal weight (BMI 18.50–24.99 kg/m2; reference group); Over weight (BMI 25.00–29.99 kg/m2); obese class I (BMI 30.00– 34.99 kg/m2); obese class II (BMI 35–39.99 kg/m2); and obese class III (BMI _ 40 kg/m2). Maternal and neonatal outcomes were examined using logistic regression, adjusted for confounding variables. RESULTS : The study highlights a relationship between increasing BMI (from overweight to obese class III) and increasing risk of adverse outcomes, including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy, caesarean section, macrosomia, and neonatal unit admission, with women in the highest obesity group at risk of additional adverse out-comes, including stillbirth, a longer postnatal stay, and wound problems following caesarean section.By categorising women into overweight and obesity sub classifications (classes I –III), this study clearly demonstrates an increasing risk of adverse outcomes across BMI categories, with women who are overweight also at significant risk both in terms of maternal and neonatal outcomes. }, keywords = {Deccan School of Pharmacy, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Moghadam_2016, title = {Clinical & surgical study of inguinal hernia}, author = {Abdul Ghader Barazaneh Moghadam and Syed Asif Shah Harooni}, url = {https://www.jebmh.com/abstract/clinical-and-surgical-study-of-inguinal-hernia-82611.html}, issn = {2349-2562}, year = {2016}, date = {2016-03-30}, urldate = {2016-03-30}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {3}, issue = {90}, pages = {5667-5670}, abstract = {BACKGROUND: It maybe said with assurance that inguinal hernia is among the oldest of man's maladies and one of the first to be recognised, so inescapable in its appearance and so tell-tale the discomfort. The treatment of hernia, in particular, inguinal hernia, which is the most common type of hernia that occurs in population has got drastic changes in the last 100 years. In the period before Bassini started doing hernia surgery, the recurrence rate was 100% by 4 years. Now, it is <1%. Especially, the invasion of laparoscopy has changed the scenario. Laparoscopy is used in emergency inguinal surgeries also. Although, we have made a great progress in treating hernia, the management of its complications has made little, the postoperative complications, mortality are alarmingly high, especially in the aged people in case of strangulated inguinal hernia. Obstructed inguinal hernia is one complication of inguinal hernia that precedes strangulation. If one could interfere at the stage of obstruction and treat it in correct time, we can avoid major morbidity and mortality. A sincere effort has been put in this study to understand the clinical and surgical aspects, outcomes and the complications while addressing these issues. MATERIALS AND METHODS: Eighty patients who attended the OPD in the Department of General Surgery were taken up for the study. This study was done in the Department of General Surgery, Deccan College of Medical Sciences, Hyderabad. The study was done from 2013 to 2015. RESULTS: Bleeding is significantly associated with open type of repair in early complications. Chronic pain is significantly associated with open type of repair in late complications. CONCLUSION: This study successfully studies the clinical and surgical aspects of inguinal hernia. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @bachelorthesis{Syeda_2016, title = {Evaluation of diuretic activity of ethanolic extracts of cucurbita maxima seeds in rats}, author = {Shakira Fathima Syeda and Sam Pavan Kumar G. and Mohammed Mohsin and Pushpalatha C.}, url = {http://www.jcmad.com/admin/pdf/419a14.pdf}, issn = {2347-4513}, year = {2016}, date = {2016-03-20}, urldate = {2016-03-20}, journal = {Journal of Contemporary Medicine and Dentistry }, volume = {4}, issue = {1}, pages = {62-67}, abstract = {Background: Kidneys play an important role in water and electrolyte conservation and it forms an integral part of body homeostatic mechanism. Diuretics are drugs used to treat several conditions including cardiac failure, Nephrotic syndrome, cirrhosis of Liver and treatment of hypertension. In the present study we tried to evaluate the antidiuretic activity of extracts of cucurbita maxima Duchesne (commonly known as pumpkin) in Rats. Methods: Adult albinorats of either sex weighing in between 150-200gms were used. The diuretic activity of Cucurbita Maxima at the dosage of 150mg/kg and 300mg/Kg was compared with Standard drug Furosemide at the dosage of 20mg/Kg. Diuretic activity was measured by collecting total excreted urine (0-5hrs) the rats being kept in metabolic cage. Results: The urinary volume during the period of the 5hr collection in Group I [Control] was 1.96±0.12 ml/kg. In the Group II which was treated with 20mg/kg of furosemide, there was a significant increase in the urinary volume i.e. 4.71±0.83 ml/Kg. In the test Group III treated with Cucurbita maxima at dosage of 150mg/Kg, the urinary volume was significantly greater than control. The urinary volume for the Test-1 group was found as 3.33±0.34 ml/Kg and Group IV treated with Cucurbita maxima at dosage of 300mg/Kg was found to be 3.55±0.51ml/kg. Conclusions: Cucurbita maxima produced a significant increase in urinary volume, urinary and Serum electrolytes excretion when compared to control. The diuretic activity was more significant at 300 mg/kg body when compared to control. From this study, it may be concluded that the ethanolic extract of Cucurbita maxima produces significant diuresis however its effect is not as strong as standard drug Furosemide.}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {bachelorthesis} } @article{Thaher_2016, title = {Clinical presentation and outcome of dengue cases in tertiary care hospital, Hyderabad}, author = {Mohammad Abdul Thaher and Sultan Rizwan Ahmad and A. Chandrasekhar}, url = {https://www.bibliomed.org/mnsfulltext/67/67-1455086956.pdf?1693291773}, doi = {10.5455/ijmsph.2016.09022016405}, issn = {2277-338X}, year = {2016}, date = {2016-03-01}, urldate = {2016-03-01}, journal = {International Journal of Medical Science and Public Health}, volume = {5}, issue = {10}, abstract = {Background: Dengue viral infection, i.e., dengue fever (DF), and its sever form, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), form the most important mosquito-borne diseases and have become a major global public health concern. The World Health Organization estimates that 50 million dengue infections occur annually and 500,000 people require hospitalization each year. Objective: To evaluate the clinical features and outcome of dengue infection case admitted in a tertiary-care hospital (government fever hospital) in Hyderabad. Materials and Methods: A hospital record-based descriptive study was performed in a tertiary-care hospital in Hyderabad. Medical records of 80 seropositive dengue patients who were admitted from July 1 to August 31, 2015 were studied and analyzed. Result: Of 80 seropositive dengue patients, 25% were female and 75% were male patients, 24% patients were <15 years of age, and 9% patients were above 45 years, while majority (67%) belonged to age group of 15–45 years, with the majority in that being students. Mean hospital duration stay was 4.76 ± 1.53 days; 45% of patients showed DF, 21% DHF stage I, 19% DHF stage II, 9% DHF stage III, and 6% DHF stage IV. All 45% patients of DF revealed platelet count more than 100,000; remaining 55% patients of DHF and DSS showed platelet count less than 100,000. All 85% patients up to DHF stage II were normotensive patients, while 15% patients belonging to DHF stages III and IV showed hypotensive condition. Conclusion: Dengue infection ranges from mild self-limiting illness to severe disease with high cure rate. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Gul_2016, title = {A rare case of anhidrotic ectodermal dysplasia in a six-year-old boy}, author = {Bismah Gul and Uppin Narayan Reddy and Swathi Chacham and Mir Sumsam Ali Khurram and Naila Mazher and Taha Mustafa and E. Apoorva}, url = {https://www.ijcasereportsandimages.com/archive/2016/002-2016-ijcri/CR-10608-02-2016-gul/ijcri-1060802201608-gul.pdf}, doi = {10.5348/ijcri-201621-CR-10608}, issn = {0976-3198}, year = {2016}, date = {2016-02-01}, journal = {International Journal of Case Reports and Images}, volume = {7}, issue = {2}, pages = {127-131}, abstract = {Introduction: Ectodermal dysplasia is a rare, non-progressive, genetic disorder resulting from abnormal development of two or more tissues at a time which are derived from the embryonic ectoderm. It classically manifests with skin, eccrine gland, nail and hair changes, with an incidence of 1 in 1, 00,000 births. More than 170 different syndromes have been identified. X-linked recessive anhidrotic dysplasia (XLHED) being the most common type, which is expressed in males. Case Report: A six-year-old boy, was bought to the pediatric outpatient department with the complaints of fever on and off since month months. The parents gave history of recurrent episode of hyperpyrexia, with heat intolerance, absent sweating and delayed dentition in the past. On examination the child had peculiar facies, characterized by malar hypoplasia, flattening of nasal bridge, everted lips, wrinkled periorbital skin, pegged shaped tooth, low set ears, scanty, hypopigmented hair on the head; with absent eyebrows and eye lashes. Even after thorough evaluation and investigation, no focus of infection was found, ectodermal dysplasia was then considered and a skin biopsy done, which showed absence of skin appendageal structures. Conclusion: We report a rare case of anhidrotic ectodermal dysplasia in a 6-year-old boy, thus emphasizing the need for considering EDA as a differential diagnosis for neonates and infants with history of fever of unknown origin specially when associated with delayed dentition and hypotrichosis. An early diagnosis would have prevented unnecessary antibiotic misuse. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Nalluri_2016, title = {Variations in attachments and nerve supply of third head of biceps brachii: A study in South Indian population}, author = {Hima Bindu Nalluri and Parimala Sirikonda and Vasanta Leela}, url = {https://www.ijmhr.org/ijar.4.1/IJAR.2015.337.html}, doi = {10.16965/ijar.2015.337}, issn = {2321-4287}, year = {2016}, date = {2016-01-31}, urldate = {2016-01-01}, journal = {International Journal of Anatomy and Research}, volume = {4}, issue = {1}, pages = {1795-1801}, publisher = {I MED Research Publications}, abstract = {Background: Biceps brachii muscle normally has two heads; the long head and the short head. Sometimes it has a third head or supernumerary head. Variations in the attachments of the third head of biceps brachii are clinically important. Aim: This study was undertaken to evaluate the incidence, attachments, relations and nerve supply of the third head of biceps brachii in a South Indian Population. Material and methods: Both the upper limbs of 40 formalin-fixed cadavers (80 upper limbs) were studied for the possible presence of supernumerary heads of biceps brachii. The anterior compartment of arm was dissected and the biceps brachii muscle was exposed. The attachments, relations and nerves supplying biceps brachii, were delineated. Results: It was found that Biceps brachii had two heads in 36 cadavers. A third head was observed in 4 cadavers. It was bilateral in one cadaver and unilateral in three cadavers. This third head of biceps brachii arose from the coracoid process along with its short head, bilaterally, in one cadaver. It originated from the medial surface of the shaft of humerus at the insertion of coracobrachialis, in left upper limb of one cadaver. The third head originated from the shaft of humerus along with the medial fibers of brachialis in the right upper limb of one cadaver; and both from shaft of the humerus and medial intermuscular septum in the right upper limb of another cadaver. In three cases it was innervated by the musculo-cutaneous nerve. In one case it was innervated by the branches of the median nerve, where the musculo- cutaneous nerve was absent. All the three heads fused before the formation of bicipital tendon and inserted into the radial tuberosity. But in one case, a few fibers of the third head inserted into the bicipital aponeurosis. Conclusion: In our study the incidence of third head was 10%. In published literature, its incidence varies from 0.18% to 21.5% in different populations. Variation in the attachments of third head of biceps brachii is important in surgical interventions, neurovascular compression syndromes and unexplained pain syndromes in arm and forearm regions.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Koti_2016, title = {Attenuation of haemodynamic response to intubation with oral clonidine and oral atenolol}, author = {Vijaya Rekha Koti and Saratbabu Chevuri and Sunil Pulla and Varunchander G}, url = {https://www.ijca.in/journal-article-file/2002}, doi = {10.5958/2394-4994.2016.00046.9}, issn = {2394-4781}, year = {2016}, date = {2016-01-31}, urldate = {2016-01-31}, journal = {Indian Journal of Clinical Anaesthesia}, volume = {3}, issue = {2}, pages = {251-256}, abstract = {A comparative study is done between oral Atenolol and oral Clonidine in the attenuation of cardiovascular response during laryngoscopy and intubation. 50 adult patients undergoing various elective surgeries of ASA grade 1, Mallampatigrade 1 were selected and informed consent was taken for all the cases. Patients were of both sexes and age ranging from 18 to 60 years. The study was done in two groups. Group 1 consisted of 25 patients where atenolol 0.75mg per kg body wt was given orally 3 hrs before the scheduled time of the surgery. Group 2 consisted of 25 patients where clonidine 3 micrograms per kg body wt was orally given 90min before schedules time of surgery. The drugs given in premedication were inj.glycopyrollate 10mcg/kg, inj. midazolam 40mcg/kg and inj.ondansetron 0.08mg/kg. Induction of anesthesia was achieved by inj. thiopentone in a dose of 5mg/kg iv. Tracheal intubation was facilitated with inj. suxamethonium 2 mg/kg iv.Hemodynamic parameters (BP, HR, MAP) were recorded at the intervals of Pre induction, After induction, During laryngoscopy and intubation, 1 min, 3 min, 5 min after intubation. Data was compared between the two groups of patients. Group 1 did not show a significant increase in various hemodynamic parameters. Group 2 showed higher increase in hemodynamic parameters compared to oral atenolol. Hemodynamic parameters returned to the baseline at the end of 5 min in the atenolol group whereas it took more than 5 min to return to the basal value and it has less effect on the heart rate in clonidine group compared to atenolol group. The following conclusion can be drawn from our study. Oral atenolol attenuates the increase in heart rate to laryngoscopy and intubation more effectively than oral clonidine. Oral atenolol blunts the increase in systolic, diastolic and mean arterial pressure effectively and values returned to basal value within 5 min of intubation compared to oral clonidine. No side effects were noted in atenolol and clonidine groups in our study. Hence oral atenolol in a dose of 0.75 mg/kg given 3 hrs before induction of anaesthesia is effective in attenuating hemodynamic response to laryngoscopy and endotracheal intubation when compared to oral clonidine.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2016, title = {Seroprevalence of hepatitis A and E virus infections in patients with acute viral hepatitis in Hyderabad, India- a one year study}, author = {Sarwat Fatima and Syyeda Anees and Anjum Ayesha}, url = {https://journaljammr.com/index.php/JAMMR/article/view/2146/4306}, doi = {10.9734/bjmmr/2016/21879}, issn = {2231-0614}, year = {2016}, date = {2016-01-10}, urldate = {2016-01-10}, journal = {British Journal of Medicine and Medical Research}, volume = {11}, issue = {10}, pages = {1-9}, abstract = {Introduction: Acute viral hepatitis due to faeco- oral group of hepatitis viruses is endemic in India. Outbreaks of hepatitis E virus infection are more common than the hepatitis A virus. Aim: The present study aimed at determining the seroprevalence of IgM antibodies to hepatitis A and E virus in clinically diagnosed acute viral hepatitis cases. And to determine its usefulness against the disease prevention. Study Design: A cross sectional study was carried out on symptomatic patients referred from paediatric and gastro enterology department of Princess Esra hospital. Place and Duration of Study: Around one hundred and eight subjects were analyzed for anti IgM antibodies to hepatitis A and E virus and liver function test in the department of laboratory medicine for Microbiology and biochemistry at Princess Esra Hospital, Deccan College of Medical Sciences between January 2013 and January 2014. Methodology: Blood samples were collected under strict aseptic precautions and tested for anti-HAV and Anti-HEV IgM antibodies using capture elisa from diasorin. Biochemical analysis included estimation of serum aminotransferases, alkaline phosphatase and bilirubin levels. Results: An overall seropositivity of 54% was observed in the present study. More number of the subjects as 46.29% tested positive for anti HAV IgM than for anti HEV IgM as 7.4%. Co-infections were not noticed. Acute viral hepatitis due to hepatitis A virus is more common in children in the age group 6-10 years followed by 11-15 years and lastly 0-5 years indicating the epidemiological shift. Infection with hepatitis E virus was common in adolescent and adults. Males were more susceptible to both the infections than females. Liver function test results correlated well with viral markers indicating damage to the liver parenchyma. The socioeconomic status of the individuals revealed that 95% of the subjects were below poverty line and didn’t have access to proper drinking water and sanitary facilities. None were vaccinated against Hepatitis A virus. Conclusion: The present data suggest that we need to have a dual pronged approach against prevention of acute viral hepatitis caused by A and E virus. Government authorities should prioritize on bringing a uniform improvement in the living standards of the society and make vaccine available to the high risk group at a subsidized rate.}, keywords = {Biochemistry, Microbiology}, pubstate = {published}, tppubtype = {article} } @article{Rozati_2016, title = {History of gestational diabetes mellitus leading to type 2 diabetes mellitus in Hyderabad population}, author = {Roya Rozati and A. G. Mehdi and Akila Ch. and Surayya Tahseen and Avinash Bardia and Aleem Ahmed Khan}, url = {https://www.ommegaonline.org/articles/publishimages/10691_History-of-Gestational-Diabetes-Mellitus-Leading-to-Type-2-Diabetes-Mellitus-in-Hyderabad-Population.pdf}, doi = {10.15436/2380-5595.15.720}, issn = {2380-5595}, year = {2016}, date = {2016-01-04}, urldate = {2016-01-04}, journal = {Journal of Gynecology and Neonatal Biology}, volume = {2}, issue = {1}, pages = {1-4}, abstract = {Background: Women having gestational diabetes mellitus are at greater risk of effecting type 2 diabetes mellitus. Particularly because of the scarcity of data in India, there is requirement for understanding the distribution and possibility factors of dysglycaemia (types 2 diabetes mellitus and prediabetes) in women having affected earlier with gestational diabetes mellitus. Methods: All women (n = 751) with past history of GDM attending two obstetric units in Hyderabad were invited to participate in the study. Among them 279 (37.15%) accepted to take part in the present study. Socio-demographic, medical and anthropometric information were collected; and 75gm OGTT performed. Results: 213 (76.34%) women were found dysglycaemic within 5 year (median 14 months) of the pregnancy. Age was found to be 1.27 fold increase risk of having dys- glycaemia (OR 1.27, 95% CI 1.03 - 1.35 p = 0.03). Presence of acanthosis nigricans (OR 2.09, 95% CI 1.89 - 6.56 p = 0.002), postpartum screening interval (OR 1.41, 95% CI 1.15 - 1.92 p = 0.02) were found to be risk factors to have dysglycaemia. The ADA suggested threshold HbA1c value of >39 mmol/mol (5.6%) have a sensitivity and specificity of 72.3% and 67.3% respectively for detecting the occurrence of T2DM postpartum. Conclusion: In conclusion, this study found a high possibility of development of t2dm among with a history of gdm and there is an immediate need to improve post-partum screening rates.}, keywords = {Central Research Laboratory, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2016, title = {Effect of ongoing isometric handgrip exercise on the inspiratory and expiratory reserve volumes}, author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Mohammed Abdul Haq Junaid and Mohammed Asghar Ali}, url = {https://njppp.com/?mno=220771}, doi = {10.5455/njppp.2016.6.03032016134}, issn = {2320-4672}, year = {2016}, date = {2016-01-01}, urldate = {2016-01-01}, journal = {National Journal of Physiology, Pharmacy and Pharmacology}, volume = {6}, issue = {4}, pages = {329-332}, publisher = {ScopeMed}, abstract = {Background: Chronic diseases such as hypertension and diabetes have shown improvement in disease condition on isotonic exercises. But the same can cause deterioration in the health of patients with asthma, heart failure, and chronic obstructive pulmonary disease. Therefore, in such individuals, isometric exercise can be given a try. Isometric exercise is known to activate the autonomic nervous system, especially the parasympathetic fibers and thus has a bearing on the functioning of respiratory system. Aims and Objectives: This study was undertaken with a purpose to find acute change in respiratory reserve during handgrip exercise. Materials and Methods: 50 young apparently healthy volunteers between the ages of 18 to 35 years were enrolled for the study. Different spirometry volumes and capacities including inspiratory reserve volume (IRV) and expiratory reserve volume (ERV) were recorded on MedSpiror (RMS, Chandigarh, India) at baseline and during sustained hand grip using a hand dynamometer. Statistical analysis was done using SPSS 17.0 on the data obtained. Result: This study showed that FVC was significantly reduced during handgrip exercise. FEV1, PEFR, FEF 25-75% and IRV decreased while FEV1/FVC and ERV increased but these changes were not significant statistically. Conclusion: The reserve capacity of the lung does not change significantly during isometric exercise.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Fatima_2016, title = {Evaluation of ApoB and A-1 as Cardiac markers in young adult population}, author = {Fatima Jabeen and Syyeda Anees and Sudha Bala}, url = {https://jmscr.igmpublication.org/v4-i6/55%20jmscr.pdf}, doi = {10.18535/jmscr/v4i6.55}, issn = {2347-176X}, year = {2016}, date = {2016-01-01}, urldate = {2023-01-01}, journal = {Journal of Medical Science and Clinical Research}, volume = {4}, issue = {6}, pages = {11013-20}, abstract = {Clinically normal young adults with no well-known risk factors may present with metabolic syndrome, hypertension, atherogenic dyslipidemia and type-II diabetes. Age and sex are two non-modifiable risk factors for developing cardiovascular disturbances which may affect the levels of apolipoprotein B and apolipoprotein A-I. The objective is to study serum apo B and A-I levels in association with the conventional lipid profile parameters in atherogenic dyslipidemia. In this hospital-based prospective study, clinically normal males (n=172) and females (n=188), aged between 20-39 years, divided into two age groups: group-I (20-29 years) and group-II (30-39 years), subjected to overnight fasting had their lipid profile parameters (enzymatic colorimetric assay) along with the serum levels of apoB and apoA-I (immunoturbidimetry method) estimated. Subjects with body mass index (BMI) >30 were excluded from the study. Data was statistically analysed using Chi-square test and ROC curves. ApoB levels showed continuous increase with age in both sexes with males having significantly raised (p<0.01) levels in both groups compared to females. ApoA-I levels declined with increasing age in both sexes and this decline was relatively earlier in males. Within each group females were having relatively raised (p<0.05) apoA-I levels than males. Moderate to strong correlations were observed between serum apoA-I and HDL-C concentrations (p<0.0001) and between serum apoB and LDL-C concentrations (p<0.0001), respectively. ApoB may be a more sensitive measure of atherogenic dyslipidemia than LDL-C and a better index for assessing cardiovascular risk, whereas apoA-I did not add significantly to the estimation of future atherosclerotic vascular risk.}, keywords = {Biochemistry, Community Medicine}, pubstate = {published}, tppubtype = {article} } @book{Hasan_2016, title = {The Slow Stain}, author = {Ashfaq Hasan}, isbn = {9879352671144}, year = {2016}, date = {2016-01-01}, booktitle = {The Slow Stain}, publisher = {Ashfaq Hasan}, address = {Hyderabad}, edition = {2nd}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @article{Uzma_2015, title = {Epidemiology, clinical profiles and risk factors in obstructive sleep apnea}, author = {Nazia Uzma and Ashfaq Hasan and Bhaskarpillai Santhosh Kumar and Hamid Abdul Qaiyum and Doddamani R. Basalingappa and Vontela Devender Reddy}, url = {https://www.minervamedica.it/en/journals/minerva-respiratory-medicine/article.php?cod=R16Y2015N04A0161#}, issn = {2724-6493}, year = {2015}, date = {2015-12-31}, journal = {Minerva Pneumologica}, volume = {54}, issue = {4}, pages = {161-168}, publisher = {Edizioni Minerva Medica}, abstract = {Obstructive sleep apnea (OSA) is a common medical condition with significant adverse effects but it remains undiagnosed in many individuals. The present hospital based study assessed the prevalence, related clinical features and risk factors of OSA in the South Indian population. One ninety two untreated OSA patients and sixty two control subjects were included in this study. Each subject underwent a fully attended polysomnogram (PSG), spirometric analysis, modified OSA questionnaires and Mallampati score were obtained in study population. The OSA patients were divided into three subgroups: mild (29%), moderate (15%) and severe (56%) and the mean±SD of Apnea-Hypopnea Index (AHI) was 11.4±3, 24.8±5.1 and 36.6±7.4 respectively. Higher Mallampati score was observed in patients with severe OSA than in moderate and mild OSA patients. An apparent decrease in FVC and FEV1 was observed in OSA group with a positive correlation with increase in AHI. A significant decrease in FVC, FEV1 and FEV1/FVC was observed with increase in Body Mass Index (BMI), reflecting the increased restrictive pattern in the OSA groups. Sleep onset latency was increased to 18.6±13.2 than 8.8±3.2 with a sleep efficiency of 74.2±4.8 and 90.2% in OSA group and controls respectively. The apnea index, hypopnea index and microarousals were much higher in the OSA groups than in controls. Statistically significant differences were perceived in the fasting blood glucose levels, triglyceride, LDL, HDL and total cholesterol levels between the OSA group and controls. This study adds evidence for a link between the clinical features, epidemiology and risk factors of OSA.}, keywords = {Otorhinolaryngology, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2015, title = {Correlation of BMI with lipid profile in adult females}, author = {Farisa Khatoon and Asra Tayyab}, url = {https://www.cibtech.org/J-Innovative-Research-Review/Publications/2015/VOL-3-NO-4/03-JIRR-003-FARISA-BMI.pdf}, issn = {2347–4424}, year = {2015}, date = {2015-12-31}, journal = {International Journal of Innovative Research and Review}, volume = {3}, issue = {4}, pages = {10-11}, abstract = {The present study aimed at assessing the effect of body mass index on lipid profile among adult females. Obesity is important risk factor of dyslipedemia and other related complications. The current study was done to correlate anthropometric indices with lipid profile of individuals. Dyslipedemia is abnormal increase of lipids in body, it is manifested by high levels of cholesterol, low density lipoproteins, and triglycerides. It has gained lot of importance due to various risk factors implicated in causing coronary artery diseases.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2015, title = {The singular case of the pleural effusion}, author = {Ashfaq Hasan}, url = {https://jmas.in/fulltext/154-1449159001.pdf?1676967274}, issn = {2231-1696}, year = {2015}, date = {2015-12-01}, urldate = {2015-12-01}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {2}, pages = {24-25}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Nori_2015, title = {MRI evaluation of post core decompression changes in avascular necrosis of hip}, author = {Madhavi Nori and Sravan Kumar Marupaka and Swathi Alluri and Mohammed Naseeruddin and Kazi Amir Irfan and Jampala Venkateshwarlu and Sunil Apsingi and Krishna Kiran Eachempati}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717750/pdf/jcdr-9-TC04.pdf}, doi = {10.7860/JCDR/2015/13995.6967}, issn = {0973-709X}, year = {2015}, date = {2015-12-01}, urldate = {2015-12-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {9}, issue = {12}, pages = {TC04-TC08}, abstract = {Introduction: Avascular necrosis of hip typically presents in young patients. Core decompression in precollapse stage provides pain relief and preservation of femoral head. The results of core decompression vary considerably despite early diagnosis. The role of MRI in monitoring patients post surgically has not been clearly defined. Aim: To study pre and post core decompression MRI changes in avascular necrosis of hip. Materials and Methods: This is a contiguous observational cohort of 40 hips treated by core decompression for precollapse avascular necrosis of femoral head, who had a baseline MRI performed before surgery. Core decompression of the femoral head was performed within 4 weeks. Follow up radiograph and MRI scans were done at six months. Harris hip score preoperatively, 1 month and 6 months after the surgery was noted. Success in this study was defined as postoperative increase in Harris hip score (HHS) by 20 points and no additional femoral collapse. End point of clinical adverse outcome as defined by fall in Harris hip score was conversion or intention to convert to total hip replacement (THR). MRI parameters in the follow up scan were compared to the preoperative MRI. Effect of core decompression on bone marrow oedema and femoral head collapse was noted. Results were analysed using SPSS software version. Results: Harris hip score improved from 57 to 80 in all patients initially. Six hips had a fall in Harris hip score to mean value of 34.1 during follow up (9 to 12 months) and underwent total hip replacement. MRI predictors of positive outcome are lesions with grade A extent, Grade A & B location. Bone marrow oedema with lesions less than 50% involvement, medial and central location. Conclusion: Careful selection of patients by MR criteria for core decompression provides satisfactory outcome in precollapse stage of avascular necrosis of hip.}, keywords = {Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{pmid26229751, title = {Cost-effectiveness analysis of three different combinations of inhalers for severe and very severe chronic obstructive pulmonary disease patients at a tertiary care teaching hospital of South India}, author = {Mohammed Altaf and Ayesha Mubeen Zubedi and Fareesa Nazneen and Shaik Kareemulla and Syed Amir Ali and Mirza Misba Ali Baig and M. Aleemuddin Naveed and Mohammed Abdul Hannan Hazari}, url = {https://journals.lww.com/picp/Fulltext/2015/06030/Cost_effectiveness_analysis_of_three_different.7.aspx}, doi = {10.4103/2229-3485.159940}, issn = {2229-3485}, year = {2015}, date = {2015-09-30}, urldate = {2015-09-30}, journal = {Perspectives in Clinical Research}, volume = {6}, issue = {3}, pages = {150-158}, publisher = {Wolters Kluwer - Medknow}, crossref = {Altaf_2015}, abstract = {Background: This study aims at simplifying the practical patient management and offers some general indications for pharmacotherapeutic choice by the implementation of (Global Initiative for Chronic Lung Disease) guidelines. This study was designed to evaluate the clinical and economic consequences of salmeterol/fluticasone (SF), formoterol/budesonide (FB), and formoterol/fluticasone (FF) in severe and very severe chronic obstructive pulmonary disease (COPD) patients. Objectives: The aim was to find out the most cost-effective drug combination between the three combinations (SF/FB/FF) in COPD patients. Materials and Methods: A prospective observational comparative study (cost-effectiveness analysis), in which 90 severe (30 ≤ forced expiratory volume in 1 s [FEV1] <50% predicted) and very severe (FEV1 < 30% predicted) COPD patients (outpatients/inpatients) who are prescribed with any one of the following combinations (SF/FB/FF) were selected. In our study, we have divided 90 COPD patients into three groups (Group I, Group II, and Group III) each group consisting of 30 patients. Group I was prescribed with medication SF, Group II with medication FB, and Group III with medication FF. We used five different parameters such as spirometry test (mean FEV1 initial and final visit), number of symptom-free days (SFDs), number of moderate and severe exacerbations, Number of days of hospitalization and direct, indirect, and total cost to assess the cost-effectiveness of SF/FB/FF. Comparison of cost and effects was done during the period of 6 months of using SF/FB/FF. Results: The average FEV1 for Group I, Group II, and Group III subjects at initial visit was 33.47%, 33.73%, and 33.20% and was increased to 36.60%, 35.8%, and 33.4%, respectively. A 3% increment in FEV1 was reported for Group I subjects (SF) and was highly significant statistically (t = −8.833, P = 0.000) at 95% CI. For Group II subjects (FB), a 2% increment in FEV1 was reported and was highly significant statistically (t = −9.001, P = 0.000) at 95% CI. For Group III (FF) subjects 0.2% increment in FEV1. The overall mean total cost for Group I, Group II, and Group III subjects during the 6 months period was found to be Rs. 29,725/-, Rs. 32,602/- and Rs. 37,155/-. Incremental cost-effectiveness of FB versus SF was Rs. 37,781/- per avoided exacerbation and Rs. 661/-per SFD. Conclusion: This study highlights the favorable therapeutic performance of combined inhaled bronchodilators and corticosteroids (SF/FB/FF), thus suggesting that healthcare costs would be also affected positively. Results from our study showed that SF and FB were the most effective strategies in the treatment of COPD, with a slight clinical superiority of SF. The FF strategy was not much effective (i.e. associated with fewer outcomes and higher costs).}, keywords = {Deccan School of Pharmacy, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2015, title = {Incidence of industrial and domestic cases of deaths due to electrocution}, author = {Iqbal Banu Hussain and Farisa Khatoon and Khazi Mudabbir Ahmed}, url = {https%3A%2F%2Fwww.cibtech.org%2FJ-Innovative-Research-Review%2FPublications%2F2015%2FVOL-3-NO-3%2F10-JIRR-15-FARISA-Electrocution.pdf}, issn = {2347–4424}, year = {2015}, date = {2015-09-30}, urldate = {2015-09-30}, journal = {International Journal of Innovative Research and Review}, volume = {3}, issue = {3}, pages = {69-70}, abstract = {Deaths from electrocution may be mostly accidental and very rarely suicidal or homicidal electrical energy involving low tension or low voltage currents commonly employed in the home and industry cause most accidents from electric shock. The present study reveals that electrocution deaths be thoroughly documented and investigated for safety, prevention and compensatory reasons. In the present study 43 cases were taken out of which 29 were domestic and 11 were industrial and 3 were unknown.}, keywords = {Forensic Medicine, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Afroze_2015, title = {A case of ambiguous genitalia diagnosed in a young male presenting clinically with left sided obstructed inguinal hernia}, author = {Idrees Akhtar Afroze and Fakeha Firdous and Syed Sibghatullah Quadri and Mohammed Abdul Majid Adil}, url = {https://www.statperson.com/Journal/ScienceAndTechnology/Article/Volume16Issue2/16_2_43.pdf}, issn = {2249-8109}, year = {2015}, date = {2015-09-11}, urldate = {2015-09-11}, journal = {International Journal of Recent Trends in Science and Technology}, volume = {16}, issue = {2}, pages = {398-400}, abstract = {Ambiguous genetalia is a disorder of sex development (DSD). It occurs when something goes wrong during pregnancy to interrupt or disturb the fetus developing sex organs. Presence or absence of male hormones control the development of sex organs. A disruption of steps that determine sex can result in a mismatch between external genitals and internal sex organs or the chromosomal sex (xx or xy). Other causes can be mutations in certain genes or chromosomal abnormalities like missing sex chromosome or an extra one. Ambiguous genitalia is usually not life threatening, but can create social problem for the child and family.}, keywords = {Pathology, Urology}, pubstate = {published}, tppubtype = {article} } @article{Qaiyum_2015, title = {Chronic maxillary sinusitis-diagnosis and endoscopic management}, author = {Hamid Abdul Qaiyum and Urooj Ahmed Choudhary}, url = {https://www.ijpbs.net/abstract.php?article=NDQ2MQ==}, issn = {0975-6299}, year = {2015}, date = {2015-09-01}, urldate = {2015-09-01}, journal = {International Journal of Pharma and Bio Sciences}, volume = {6}, issue = {3}, pages = {920-920}, abstract = {Sinusitis is a common condition. Women are more often affected than men. Chronic sinusitis affects approximately 12.5% of people. Treatment of sinusitis in the United States results in more than 11 billion USD in costs. Although much has been written about the surgical technique of functional endoscopic sinus surgery (FESS), little has appeared about its long-term results.In the present study out of 42 patients 26 underwent bilateral surgeries and 16 underwent unilateral surgeries. 26 procedures of polypectomy were done. Apart from that 6 underwent septoplasty. Sphenoidotomy was done in 3 patients. Uncinectomy & MMA was done in all cases. Total ethmoidectomy was done in 10 patients, &conchoplasty was done in 7 patients. The present study validated endoscopic sinus surgery as it showed that the procedure resulted in an improvement in patient general and physical health.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Patangay_2015, title = {Temporomandibular joint dysfunction causing otalgia}, author = {Keerthi Kumar Patangay and Mohammed Naseeruddin Mujahid}, url = {https://www.journalijar.com/uploads/838_IJAR-6982.pdf}, issn = {2320-5407}, year = {2015}, date = {2015-09-01}, urldate = {2015-09-01}, journal = {International Journal of Advanced Research}, volume = {3}, issue = {9}, pages = {364-367}, abstract = {This is a retrospective study of patients reporting to ENT OPD at Princes Esra Hospital, affiliated to Deccan College of Medical Sciences , Hyderabad with otalgia between Dec 202 and Nov 2014. 452 patients reported with otalgia with different causes such as Acute Supputative Otitis Media (ASOM), Otitis externa, furuncle ear and so on and so forth. A sizeable patients in young age group were studied and found to be suffering from Temperomandibular Joint Dysfunction (TMD) with associated otalgia. In my study majority of patients belonged to younger age group of 20-40 years. I have taken into consideration patients in age group of 20-40 years for in this group TMD is most common.. After excluding various other causes of otalgia 156 cases were found to be having TMD. This constitutes 33% of cases being diagnosed to be suffering from TMD out of 452 cases reporting for otalgia. Pain due to TMD does not arise from temperomandibular joint (TMJ) for the disc and articular surface of TMJ lack innervations. The causes of TMD giving rise to otalgia are varied and complex. The contributory factors can be local, less commonly due to systemic causes such as rheumatoid arthritis or gout, but most commonly due to psychosomatic disorder for psychological stress plays a major role in causation of TMD.}, keywords = {Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Hassan_2015, title = {A case report on Fahr disease}, author = {Syed Najmul Hassan and Anjum Sultana Khatoon}, url = {https://www.cibtech.org/J-Medical-Case-Reports/PUBLICATIONS/2015/Vol-4-No-3/13-JCR-013-ANJUM-DISEASE.pdf}, issn = {2319-3832}, year = {2015}, date = {2015-09-01}, urldate = {2015-09-01}, journal = {Indian Journal of Medical Case Reports}, volume = {4}, issue = {3}, pages = {46-48}, abstract = {Fahr disease is also known as Idiopathic Basal Ganglia Calcification is a rare, genetically, dominant neurological disorder. This disease is characterized by abnormal deposits of calcium in areas of the brain that control the movement. The present study shows different CT Scans through which different calcifications are seen and analyzed.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2015, title = {Primary varicella infection associated with Steven-Johnson syndrome}, author = {Fatima Razvi and Mohammed Zoheb and Nayeem Sadath Haneef and Neha Chowdary Koganti}, url = {https://jmas.in/fulltext/154-1451056519.pdf?1675747859}, issn = {2231-1696}, year = {2015}, date = {2015-08-31}, urldate = {2015-08-31}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {2}, pages = {38-40}, abstract = {Steven-Johnson Syndrome (Erythema Multiforme Major) is a severe occasionally fatal variant of Erythema Multiforme which is abrupt in onset accompanied by fever, malaise, headache and erosions of conjunctiva, mouth and genitilia with skin lesions in the form of erythematous macules, papules and target lesions involving less than 10% of body surface area. Varicella is caused by varicella zoster virus. It is a primary infection with a viraemic stage after which the virus persists in the sensory nerve ganglia cells, reactivation of which in the later life results in herpes zoster.Varicella is transmitted by droplet infection. Patients are usually infectious 2 days prior to 5 days after the onset of rash. Varicella confers lasting immunity and second attacks are uncommon in immunocompetent individuals. Immunoglobulin(Ig), IgG, IgM, IgA antibodies appear in about 1 week after the onset and the peak levels occur during the second and third week thereafter the titred gradually all. Immunoglobulins have incomplete protective effect, CMI is more important against the infection and if the primary infection occurs when CMI is impaired as in organ transplant patients it maybe fatal.We, report a rare association of primary varicella with Steven Johnsons Syndrome successfully treated with a combination of systemic steroids and Acyclovir. }, keywords = {Dermatology, Neurology}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2015b, title = {Generalized pustular psoriasis of pregnancy}, author = {Fatima Razvi and Nayeem Sadath Haneef and Sri Teja and Ramesh Bang and Fatima Ummul Hasnath}, url = {https://jmas.in/fulltext/154-1451059982.pdf?1675747796}, issn = {2231-1696}, year = {2015}, date = {2015-08-31}, urldate = {2015-08-31}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {2}, pages = {51-53}, abstract = {eneralized pustular psoriasis also called as Impetigo Herpetiformis is a rare eruption occurring in pregnancy characterized by generalized symmetrical grouped pustular lesions associated with constitutional symptoms. It was first described by Von Hebra. It results in placental insufficiency leading to fetal anomalies, still births and maternal morbidity. Onset of diseases is usually in the last trimester of pregnancy but we are reporting a case which occurred at 9 weeks gestation.}, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Nathani_2015, title = {Laurence-Moon-Bardet-Biedl syndrome-a case report}, author = {Manisha Nathani and Siddharth Karan and S. S. Asadullah Hussain Saberi and Syed Abdul Basith}, url = {https://ijmrr.medresearch.in/index.php/ijmrr/article/view/319/623}, doi = {10.17511/ijmrr.2015.i7.140}, issn = {2320-8686}, year = {2015}, date = {2015-07-29}, urldate = {2015-07-29}, journal = {International Journal of Medical Research and Review }, volume = {3}, issue = {7}, pages = {773-776}, abstract = {Laurence Moon Bardet Biedle syndrome is a rare, autosomal recessive genetic disorder. It has got wide spectrum of clinical features. Spastic paraplegia is predominant feature in Laurence Moon syndrome and polydactyly and obesity are predominant features in Bardet Biedle syndrome. Pigmentary retinal degeneration, mental retardation and hypogonadism are common to both. We report a case of 7 year old female who presented to us with complaints of night blindness. She showed all ocular features, most of the general features of Laurence Moon Bardet Biedl syndrome and a typical family history. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2015c, title = {A study of impact of early diagnosis in the management of choledochal cysts of infancy and childhood– experience and analysis of 205 cases}, author = {G. Raghavendra Prasad and Kasha Aishwarya and J. V. Subba Rao}, url = {https://medicalresearchjournal.org/index.php/GJMR/article/view/100518/5702}, issn = {0975-587X}, year = {2015}, date = {2015-07-14}, urldate = {2015-07-14}, journal = {Global Journal of Medical Research}, volume = {15}, issue = {2}, pages = {9-15}, abstract = {Introduction: Choledochal cyst not an uncommon encountered pediatric surgical practices. Advances in technology have impacted timing of diagnosis. Advances in instrumentation and surgical access have added yet another way of excion. But the exact impact of early diagnosis on surgery of choledochal cysts have not been analysed and reported. Hence this attempt to analyse the three periods of choledochal cyst, namely 1. PTC (Percutaneous Trans-hepatic Cholangiography) and ERCP (Endoscopic Retrograde Cholangio Pancreatography), 2. USG (Ultrasonography) and CT Scan (Computerised Tomography era, and 3 .Period of MRCP (Magnetic Resonnace Cholangio Pancreaticography) with regards to impact of early diagnosis in the management of Choledochal cysts. Materials and Methods: A total of 205 cases of choledochal cysts treated by the team were analyzed. The data retrieval was from a self developed Microsoft Access based software used by senior pediatric surgeon. The parameter studied was actual impact on surgical aspects of the three main components of surgery of choledochal cysts, namely 1. Approach to cyst excision per se, 2. Management of distal end, 3. Restoration biliary drainage. Results: The advances in imageology have lead to early diagnosis and early surgery before complications develop. This has impacted in disappearance of delayed presentation with complications as seen by the number of cases diagnosed in neonatal period. Neonatal, perinatal, rarely antenatal detection of choledochal cysts was possible due to advances in imaging choledochal cysts. All children underwent excision of cyst and common hepaticodochojejunostomy. The safety of excision particularly when dealing inflamed, adherent choledochal cysts was better with open conventional excision. Similarly the confidence of handling the distal end was more with open surgery. Laparoscopy and Robot assisted have added another surgical access to choledochal cysts. Minimal access and magnification added to better visual appreciation, but ergonomics, cost, and availability, approach to distal end remain still to be validated. Conclusions: The present series clearly show the increase in the incidence of Choledochal cyst due to advances in imageology. Also has impacted early diagnosis is early surgical removal and there by delayed presentation, and with complications like stone, recurrent cholangitis, pancreatitis, biliary cirrhosis. This technological anatomical detailing has not reflected any significant change in the surgical management of Choledochal cyst. The advances in instrumentation and minimal access surgery and Robot assisted surgery still needs to validated as safe and can be used as standard surgical option for excision of choldochal cyst.}, keywords = {Anesthesiology, Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2015b, title = {Pneumococcal disease: closing the gap}, author = {Ashfaq Hasan}, url = {https://jmas.in/fulltext/154-1451027383.pdf?1676968952}, issn = {2231-1696}, year = {2015}, date = {2015-06-30}, urldate = {2015-06-30}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {1}, pages = {1}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2015e, title = {Umbilical pilonidal sinus: a rare case report}, author = {Omar Bin Hasan and K. Suneetha and M. Mohan Rao and Syed Mohammed Sajjad Husayni}, url = {https://journals.indexcopernicus.com/api/file/viewByFileId/642729.pdf}, issn = {2277-8160}, year = {2015}, date = {2015-06-30}, urldate = {2015-06-30}, journal = {Global Journal of Research Analysis}, volume = {4}, issue = {6}, pages = {63-64}, abstract = {Pilonidal sinus is a common disease of sacrococcygeal region involving natal cleft. However, it is also observed in the periumbilical area. There are only a few reports about umbilical pilonidal sinus in the literature. Here we report a case of umbilical pilonidal sins in a young female which presented as a chronic discharging umbilicus with periodical pain and swelling. It was managed surgically with excision of sinus tract and reconstruction of umbilicus.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2015, title = {Congenital isolated agenesis of epiglottis presenting with acute life-threatening event successfully managed by temporary supraglottic closure and tracheostomy}, author = {G. Raghavendra Prasad}, url = {https://www.ijopl.com/doi/IJOPL/pdf/10.5005/jp-journals-10023-1092}, doi = {10.5005/jp-journals-10023-1092}, issn = {2230-7508}, year = {2015}, date = {2015-06-30}, urldate = {2015-06-30}, journal = {International Journal of Phonosurgery & Laryngology}, volume = {5}, issue = {1}, pages = {1-3}, abstract = {Isolated agenesis of epiglottis is extremely rare. The exact incidence is unknown. Anecdotal presentations associated with Pierre Robbin syndrome maxillary hypoplasia have been reported. Agenesis of epiglottis has also been published in an adult. Isolated agenesis of epiglottis with acute life-threatening event (ALTE) has not been specifically dealt with in the literature. Hence, this is the report of six contiguous cohort of isolated agenesis of epiglottis with ALTE. Materials and methods: After the first case of isolated agenesis of epiglottis was diagnosed 2 years ago, five more such cases were treated by the group. These formed the index cases of the cohort. Decision for surgery was based on an arbitrary 3 ALTEs in 24 hours. All the patients were initially intubated. Supraglottic space was closed using interrupted unabsorbable sutures. Tracheostomy was added. At 3 to 6 months of follow-up, glottis was restored by Nd-YAG laser knife. Five out of six children are alive and thriving well. One child died before he could be actively managed. Conclusion: Isolated agenesis of epiglottis with ALTE is extremely rare. Supraglottic closure saves lives and gives enough time for pharyngoesophageal coordination to develop.}, keywords = {Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Rao_2015c, title = {Congenital rubella syndrome in a term male neonate with patent ductus arteriosus and bilateral nuclear cataracts: a case report}, author = {S. Pratap Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and Soumya Anumula and Faraaz Adil and Burli Prithvi and Naila Mazher}, url = {https://journals.indexcopernicus.com/api/file/viewByFileId/364585}, issn = {2347-6559}, year = {2015}, date = {2015-06-30}, urldate = {2015-06-30}, journal = {Scholars Journal of Medical Case Reports}, volume = {3}, issue = {6}, pages = {497-501}, abstract = {Transplacental transmission of rubella virus leads to Congenital Rubella Syndrome. It is comprised of congenital cardiac defects (most commonly patent ductus arteriosus), cataracts and sensorineural hearing loss. While prematurity and intra uterine growth retardation are frequent accompaniments of congenital rubella syndrome, at times birth weight can be normal. The possibility of fetal anomalies due to rubella virus is highest in the first 12 weeks of gestation, which decreases thereafter. PDA is highly prevalent in premature neonates, where as its presence in term neonates signifies either intra uterine infection or genetic disease. A 39weeks, 3200grams, appropriate for gestational age, male neonate was born by vaginal delivery with normal APGARS. The neonate presented with respiratory distress, precardial activity and cardiac murmur on 4th day of life. Hence, congenital heart disease was considered and echocardiography revealed patent ductus arteriosus. While PDA is common in premature neonates, it is a rare manifestation in term newborn babies. The neonate also had bilateral nuclear cataracts in the eyes, implying congenital rubella syndrome and was investigated for the same. Other systemic findings like bilateral cryptorchidism, hepatosplenomegaly and thrombocytopenia were also evident. In addition there was unconjugated hyperbilirubinemia and elevated transaminases. There were no intra cranial calcifications in neurosonogram. Congenital rubella syndrome was confirmed as rubella IgM levels in both mother and neonate were elevated. The neonate received decongestive therapy for patent ductus arteriosus. We report a term, male appropriate for gestational age neonate with PDA and bilateral nuclear cataracts along with elevated rubella IgM levels confirming congenital rubella syndrome. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2015, title = {Evaluation of lucidity in interpretation of medical prescriptions written in pediatric outpatient by the parents and attending pharmacists}, author = {Uppin Narayan Reddy and Sadiqua Anjum and J. Narsing Rao and Swathi Chacham and Mohd. Nasir Mohiuddin and Sana Afreen and Mir S. Adil and Mohd. Javeedullah}, url = {https://storage.googleapis.com/journal-uploads/ejpmr/article_issue/1435655058.pdf}, issn = {2394-3211}, year = {2015}, date = {2015-06-05}, urldate = {2015-06-05}, journal = {European Journal of Pharmaceutical and Medical Research}, volume = {2}, issue = {4}, pages = {204-213}, abstract = {Introduction: there are various problems in understanding the prescriptions, interpreting and communicating have been documented across the health care. Medicines designed for the betterment of patients health can actually prove detrimental when misused. Therefore the medicines, side effects, usage, dosage and ingredients must be properly communicated. While most doctors and pharmacist can see the importance of patient’s knowledge of prescription when dealing with medicines, most of them hardly make appropriate efforts to communicate the same to them. Methodology: This is a cross sectional study done in the out-patient department of Princess Esra hospital, Hyderabad and the pharmacies attached to it from march to may 2014. It is a 1000 bedded teaching hospital, situated in Hyderabad, providing specialized tertiary level health care services to all strata of people. A total of 232 participants were enrolled in the study, out of which 202 could be followed up at the pharmacy to analyze drug dispensing. Aims and Objectives: This study aims at evaluation of adequacy of medical prescription written by pediatric practitioner and its understanding by the parent and the pharmacist .It also aims to assess the drug dispensing at the level of pharmacist and the parental understanding of the usage of the prescribed drugs. Results: it was noticed that among the antibiotics prescribed strength of the antibiotics was written only for 54.6% of the prescription while dose (100%), frequency (97.9%), and duration to be taken (99.4%) was adequately mention. When understanding the antibiotics in the prescription by parents was evaluated it was noticed that only 35.7% could understand the strength mentioned on the prescription while dose(70.9%), frequency( 68.8%) , duration to be taken (79.5%) could be understood by 70 – 80 % of parents. Conclusion: Antibiotics usage is very high compared to the usual requirement. They are chances of higher dose of antipyretics being given inadvertently due to prescription errors. Very high usage of antihistamines is seen which has been previously proved to be harmful for small children }, keywords = {Deccan School of Pharmacy, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2015d, title = {A clinical study of pediatric patients with intussusceptions}, author = {Omar Bin Hasan and Tahera Arif and Syed Mujtaba Ibrahim}, url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview.php?val=June_2015_1433153810__132.pdf}, issn = {2277-8179}, year = {2015}, date = {2015-06-01}, urldate = {2015-06-01}, journal = {International Journal of Scientific Research}, volume = {4}, issue = {6}, pages = {418-419}, abstract = {BACKGROUND: Intussusception is one of the classic subjects of paediatric surgery.It is defined as telescoping of one segment of bowel into other. It is one of the most common paediatric emergencies, and an important cause of small bowel obstruction in children: if left untreated leads to fatal complications. AIM: To study the clinical profile of paediatric patients with intussusception in a tertiary care hospital. PATIENTS AND METHODS A prospective case series study of 50 children admitted to a tertiary care Hospital,Hyderabadwith a diagnosis of acute intussusception between May 2012 to April 2014 were included in the study.All children clinically suspected of having intussusception were evaluated by real time ultrasonography and those with positive findings were entered into the study. RESULTS: Male preponderance was observed in our study with predominant symptoms being excessive crying/Abdominal pain 100%(50 cases), followed by vomiting and mass per abdomen 80% (40).Most of the cases were idiopathic type and 22% (11) cases were secondary to lead points most common lead points being mesenteric lymph nodes 54.5% (6) cases followed by Meckel’s diverticulum and gut associated lymphoma seen in 18.1% (2) cases.The most common type of intussusception was found to be ileo-colic with 62% (32) cases being reported. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kehkashan_2015, title = {Spontaneous rupture of right uterine artery in a pregnant women- a rare entity}, author = {Anjum Kehkashan and Shanti Sree and Khaja Ali Hassan}, url = {https://www.jemds.com/data_pdf/Anjun%20kekhashan.pdf}, doi = {10.14260/jemds/2015/1116}, issn = {2278-4748}, year = {2015}, date = {2015-06-01}, urldate = {2015-06-01}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {4}, issue = {44}, pages = {7684-7688}, abstract = {CASE: A 30 years old female G4P2L2A1 at 34 wks of pregnancy with complains of acute pain abdomen more on right side and constipation, fever on & off & vomiting. After through investigations exploratory laparotomy was done which reveled spontaneous rupture right sided uterine artery with 1000ml of haemoperitoneum. Hysterectomy was performed after delivering the baby due to uncontrolled bleeding & difficult homeostasis. Because of maternal vital signs become unstable & homeostasis was difficult hysterectomy was performed & blood transfusion administered. Although very rare, hemoperitoneum should be included in the differential diagnosis when a pregnant women experiences acute onset, severe abdominal pain, even without an episode of abdominal trauma. BACKGROUND: Spontaneous rupture of uterine artery during pregnancy is rare, presenting symptom include acute onset abdominal pain & maternal hypovolemic collapse due to hemoperitoneum. A typical case of subculture uterine artery rupture @ 34wks. of gestation occurred in a women. CONCLUSION: Spontaneous rupture of the uterine vessels during pregnancy is a rare complication & may lead to maternal & fetal morbidity & mortality. Diagnosis and treatment are based on the clinical symptoms of actuate abdominal pain & laboratory test of hypovolemic shock signs.}, keywords = {Anesthesiology, Obstetrics & Gynecology}, pubstate = {published}, tppubtype = {article} } @article{Qaiyum_2015b, title = {A study on outcome of nasal septal surgery}, author = {Hamid Abdul Qaiyum and Mohammed Naseeruddin Mujahid and Mayana Kaleemullah Khan and Parveen Naimath and Mohammed Ishaq}, url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/a-study-on-outcome-of-nasal-septal-surgery/Njg5MA==/?is=1&b1=&k=}, doi = {10.36106/ijar}, issn = {2249-555X}, year = {2015}, date = {2015-06-01}, urldate = {2015-06-01}, journal = {Indian Journal of Applied Research}, volume = {5}, issue = {6}, pages = {832-835}, keywords = {Central Research Laboratory, General Medicine, Otorhinolaryngology}, pubstate = {published}, tppubtype = {article} } @article{Prasad_2015b, title = {Is it time to shift to total thyroidectomy for benign thyroid disease: an analysis of 77 redo thyroidectomies}, author = {G. Raghavendra Prasad}, url = {https://www.ijopl.com/doi/IJOPL/pdf/10.5005/jp-journals-10023-1093}, doi = {10.5005/jp-journals-10023-1093}, issn = {2230-7508}, year = {2015}, date = {2015-05-31}, urldate = {2015-05-31}, journal = {International Journal of Phonosurgery & Laryngology}, volume = {5}, issue = {1}, pages = {4-6}, abstract = {Aims and objectives: To analyze redo thyroidectomies so as to get a possible answer to the controversy surrounding thyroidectomy for benign disease. Materials and methods: This is a retrospective observational cohort. From 1996 to 2010, a total 77 cases of redo thyroidectomies were performed. The data of all patients in the department were maintained on a self developed MS access-based software. The data of redo thyroidectomies were reviewed. These patients were from five districts of Andhra Pradesh, 42 were women and 35 men, 51 underwent subtotal thyroidectomy, 21 had hemithyroidectomy and 5 patients had excision procedure; all were benign. The condition varied from multinodular goiter (MNG) and solitary nodule to follicular neoplasm. There were 44 right-sided, and 43 left-sided surgeries. Recurrence occurred in seven in less than 1 year, in 49 in less than 5 years, in 11 of them in less than 10 years and 10 had recurrence after 10 years. A total thyroidectomy was performed in all. Seventy-five had benign disease. Two had suspected neoplasm; one papillary and one Hurthle cell. One patient had transient recurrent laryngeal nerve palsy. Results: Seventy-seven redo surgeries for benign thyroid disease were performed. The high rate of referrals for recurrence probably suggests inadequacy of subtotal and hemithyroidectomies for benign thyroid diseases. Conclusion: The present series of 77 redo thyroidectomies clearly suggests inadequacy of initial subtotal thyroidectomy. Evidence-based analysis of complication rates and surgical feasibility supports total thyroidectomy as the complete safe, scientifically acceptable choice of primary surgical treatment for benign thyroid disease.}, keywords = {Pediatric Surgery}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2015c, title = {Ultrasound guided pneumatic reduction of intussusception in children-a case series}, author = {Omar Bin Hasan and Syed Nusrath Farees and Syed Mujtaba Ibrahim}, url = {http://www.recentscientific.com/sites/default/files/2532.pdf}, issn = {0976-3031}, year = {2015}, date = {2015-05-28}, urldate = {2015-05-28}, journal = {International Journal of Recent Scientific Research}, volume = {6}, issue = {5}, pages = {4204-4207}, abstract = {Background: Intussusception is one of the most common paediatric emergencies, and an important cause of small bowel obstruction in children. Diagnosis and treatment of intussusception is a combined effort among the paediatrician, the paediatric radiologist, and the paediatric surgeon. For many years, open surgery has been its mode of treatment worldwide, but since few years, there is a paradigm shift in its management from immediate laparotomy after resuscitation to non-operative management. Aim: To asses the USG-guided pneumatic reduction of intussusception in children. Patients And Methods: A prospective case series study of 50 children admitted to a Tertiary care Hospital, at Hyderabad with a diagnosis of acute intussusception between May 2012 to April 2014 were included in the study. All children clinically suspected of having intussusception were evaluated by real time ultrasonography and those with positive findings were entered into the study. Results: Out of 50 children enrolled in our study, 45 patients were subjected to pneumatic reduction and among the remaining 5 cases, 4 children had spontaneous reduction and one child was directly subjected to surgery due to septicaemia. Successful reduction was seen in 38 (84.4%) of the cases and failure of reduction was seen in 7 (15.55%) of cases.The cases with failed reductions were explored surgically. In two cases manual reduction was done and definitive lead point was noted in 5 cases, out of which two children had meckel’s diverticulum, two had gut associated lymphoma and one child had appendix.These results clearly state that pneumatic reduction of intussusception can fail only in the presence of lead points or in cases of loss of bowel vascularity.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Kishan_2015d, title = {Homonymous heminopia: recovery of visual fields in acute stroke}, author = {Mutyala Gopal Kishan and Sheetal Baldava and Syed Abdul Basith}, url = {https://www.jebmh.com/articles/homonymous-hemianopia-recovery-of-visualfields-in-acute-stroke.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-05-04}, urldate = {2015-05-04}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {18}, pages = {2786-2791}, abstract = {Homonymous hemianopia the most common cause is stroke. The field defect of vascular origin the prognosis for spontaneous recovery is poor. The objective of this case was to describe the characteristics of spontaneous recovery of homonymous hemianopia. In this case left homonymous hemianopia. We have confirmed by formal visual field testing and CT scan was done which revealed right parietal infarct. Follow up of this case was done after 1 month visual field were analyzed spontaneous recovery was seen.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2015, title = {Cognitive impairment in type 2 diabetes mellitus}, author = {Mohammed Abdul Hannan Hazari and Barra Ram Reddy and Nazia Uzma and Bhaskarpillai Santhosh Kumar}, url = {https://www.sciencedirect.com/science/article/pii/S1877593411000026?via%3Dihub}, doi = {10.1016/j.ijdm.2011.01.001}, issn = {1877-5934}, year = {2015}, date = {2015-05-01}, urldate = {2015-05-01}, journal = {International Journal of Diabetes Mellitus}, volume = {3}, issue = {1}, pages = {19-24}, publisher = {Elsevier BV}, crossref = {Hazari_2015}, abstract = {Background: Type 2 diabetes mellitus (T2DM) is a modern day epidemic. Chronic course of diabetes is detrimental to the cognitive functions. Aim: To decipher the pattern of cognitive impairment in relation to the duration of diabetes. Study design: Cross-sectional. Material and methods: T2DM patients (Group I: ⩽5 years duration of diabetes, n = 11; Group II: >5 years duration of diabetes, n = 17) without clinical evidence of central nervous system damage and non-diabetic controls (n = 18) were studied clinically and P300 event-related potentials (ERPs) recorded using three stimuli oddball paradigm. Subjects were examined with Folstein mini-mental state examination (MMSE) for cognitive function and those showing scores more than 26 (maximum score = 30) were enrolled for the study. Patients with known diabetic complications were excluded. Results: P300 latencies in diabetic group did not relate linearly to the duration of diabetes. Diabetic subgroups with ⩽5 years and >5 years duration of diabetes showed striking differences, patients with over 5 years of disease duration had much prolonged P300 latencies in contrast to patients with 5 years or less disease duration who showed trends similar to that of control group. Differences in P300 amplitudes between groups were non-significant. Hypertensive diabetics showed much prolongation in P300 latencies compared to normotensive diabetics. Conclusions: P300 ERPs revealed cognitive dysfunction which was not detected by neuro-psychometric test (MMSE). Patients with T2DM have decreased cognitive function which is more prominent when the disease duration exceeds 5 years. Co-existence of hypertension with T2DM further increases the risk of cognitive impairment.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2015d, title = {Bilateral cryptorchidism with bilateral synchronous testicular germ cell tumor}, author = {M. Mohan Rao and Syed Nusrath Farees and Omar Bin Hasan}, url = {http://www.journalijar.com/uploads/931_IJAR-5792.pdf}, issn = {2320-5407}, year = {2015}, date = {2015-05-01}, urldate = {2015-05-01}, journal = {International Journal of Advanced Research}, volume = {3}, issue = {5}, pages = {19-22}, abstract = {Cryptorchidism, or undescended testis (UDT), is defined as failure of a testis to descend into a scrotal position. We present a case report of 37 year old male with bilateral undescended testis and azoospermia who gave history of surgery at the age of 2 years for repositioning of both the testis into scrotum with failure of the procedure within 1 year of surgery. Clinical examination and imageology revealed both the testis in inguinal region with features of atrophy. Bilateral inguinal orchidectomy was done and histopathology revealed seminoma in both the testis .Postoperative Biomarkers and PET-Scan showed no evidence of metastases.}, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Rao_2015b, title = {A preterm very low birth rate male néonate with refractory hypoglycaemia and hyperinsulinema and hyperammonemia: a rare case report}, author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and Mohd. Ahmedulla Khan and Jakkampudi Nagasravani}, url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10504-05-2015-rao/ijcri-1050405201504-rao.pdf}, doi = {10.5348/ijcri-201543-CR-10504}, issn = {0976-3198}, year = {2015}, date = {2015-05-01}, urldate = {2015-05-01}, journal = {International Journal of Case Reports and Images}, volume = {6}, issue = {5}, pages = {272-275}, abstract = {Introduction: Hypoglycemia is an important metabolic complication in neonates, more so in newborns with perinatal risk factors. Physiological immaturity of gluconeogenesis, lipolysis coupled with hyperinsulinemia contributes to hypoglycemia in small for gestational age (SGA) neonates. Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a hyperinsulinemic condition is an important differential diagnosis for intractable and refractory hypoglycemia. Hyperinsulinemic-hyperammonemia (HI/HA) syndrome, a rare autosomal dominantly inherited disorder, is the second most common cause for hyperinsulinemic-hypoglycemia in infancy. Both symptomatic as well as asymptomatic hypoglycemia involves the occipital cortex leading to cortical blindness, necessitating early etiological diagnosis and prompt intervention. We report a preterm male neonate with rare manifestations of refractory hypoglycemia, hyperinsulinemia and hyperammonemia. Case Report: A 30 weeks, 1300 grams male neonate, born by C-section had respiratory distress, requiring mechanical ventilation (MV) for 10 days. On 11th day of life, neonate developed recurrent apneic episodes along with jitteriness and seizures. Initial evaluation revealed low blood sugar levels which persisted despite high glucose infusion rate (GIR 12 mg/kg/min). There was hyperammonemia (serum NH3 levels 273 µg/dL) along with hyperinsulinemia. However, the serum cortisol, thyroid, growth hormone levels and blood lactate were normal. Similarly, metabolic screening for inborn errors of metabolism (IEM) was normal. Abdominal imaging with ultrasound and contrast-enhanced computed tomography (CT) scan did not reveal pancreatic hyperplasia. Persistent hypoglycemia, hyperinsulinemia along with hyperammonemia could suggest hyperammonemic hyperinsulinemic syndrome in this neonate. The infant responded to oral diazoxide. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Chacham_2015, title = {Symptomatic late onset hypocalcemia in a full term female neonate with vitamin D deficiency due to maternal hypovitaminosis D: a rare case report}, author = {Swathi Chacham and Janampally Ravikiran and Uppin Narayan Reddy and J. Narsing Rao and Mahender Reddy and Imeduddin}, url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10505-05-2015-chacham/ijcri-1050505201505-chacham.pdf}, doi = {10.5348/ijcri-201544-CR-10505}, issn = {0976-3198}, year = {2015}, date = {2015-05-01}, urldate = {2015-05-01}, journal = {International Journal of Case Reports and Images}, volume = {6}, issue = {5}, pages = {276-279}, abstract = {Introduction: Neonatal hypocalcemia (NH) is a common metabolic complication in neonates, more so in premature and high risk neonates. It is classified as early and late neonatal hypocalcemia. Early NH occurs in the first 24–48 hours of life while the late NH is observed at the end of the first week. Vitamin D deficiency is an important cause for hypocalcemic seizures in neonates, in developing countries. High rate of skeletal growth coupled with low vitamin D stores and maternal vitamin D deficiency makes them vulnerable to vitamin D deficiency. Case Report: A 2600 grams, term female neonate was born to a gravid 3 mother by C-section and had normal extra-uterine transition (APGAR score: 8&9 at 5 and 10 minutes of life). On eighth day of life, the neonate had multifocal clonic seizures with normal sensorium in between. No maternal risk factors were identified. There was no fever, lethargy, poor feeding, and clinical findings were unremarkable in the neonate. There was family history of neonatal seizures. Initial blood sugar and magnesium were normal. However, serum calcium levels were low (total 5.9 mg/dL, ionized 0.9 mg/dL) along with low phosphorous levels (1.7 mg/dL). Sepsis screen was negative, blood culture was sterile and cerebro spinal fluid analysis was normal. Similarly, neurosonogram, electroencephalogram, serum ammonia and lactate were normal, suggesting late onset hypocalcemic seizures. Both the neonatal and maternal vitamin D1 and 25-OH vitamin D were low, confirming maternal vitamin D deficiency causing neonatal vitamin D deficiency. The neonate responded to calcium and vitamin D supplementation with normal serum calcium levels in follow-up. Conclusion: We report a term, female neonate with late onset hypocalcemic seizures and vitamin D deficiency, due to maternal vitamin D deficiency. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Mazher_2015, title = {A rare case of unilateral left side multi cystic dysplastic kidney and contralateral vesico-ureteric reflux in a male neonate}, author = {Naila Mazher and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and Janampally Ravikiran and Jakkampudi Nagasravani and Aslam}, url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10508-05-2015-mazher/ijcri-1050805201508-mazher.pdf}, doi = {10.5348/ijcri-201547-CR-10508}, issn = {0976-3198}, year = {2015}, date = {2015-05-01}, urldate = {2015-05-01}, journal = {International Journal of Case Reports and Images}, volume = {6}, issue = {5}, pages = {290-295}, abstract = {Introduction: Multicystic dysplastic kidney (MCDK) is a rare congenital disorder, resulting from malformation of the kidney during fetal development. It could be unilateral, bilateral or segmental and bilateral MCDK is incompatible with survival. Unilateral MCDK occurs in 1 in 4300 live births and combined incidence of unilateral and bilateral MCDK is 1 in 3600 live births. The malformed kidney is non-functional with multiple irregular cysts of varying size, separated by dysplastic parenchyma along with absent pelvicaliceal system. Case Report: A 35-week, preterm, male neonate was born to a primigravid by C-Section. There was a history of second degree consanguinity. Antenatal ultrasonography at 17th week of gestation showed left side MCDK with oligohydramnios and without other malformations,which was confirmed by fetal magnetic resonance imaging (MRI). Postnatal ultrasonography also revealed left side MCDK with grade II vesico-ureteric reflux on the right side in micturating cystourethrogram and absent function in the affected kidney in dimercaptosuccinic acid (DMSA)scintigraphy. Conclusion: We report a preterm, male neonate with antenatally detected non-functional left side multicystic dysplastic kidney with postnatal confirmation and grade II vesico-ureteric reflex on the right side. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Roohi_2015, title = {Evaluation of lipid profile, calcium and alkaline phosphatase in pregnancy induced hypertension women}, author = {Sakina Roohi and Jiyauddin Khan and M. Rosaline and Syyeda Anees and Hamid Kazi and M. Kaleemullah and Shariq Baber}, url = {https://pharmabiosciencejournal.com/index.php/pbj/article/view/2182/1543}, doi = {10.20510/ukjpb/3/i2/8934}, issn = {2347 - 9442}, year = {2015}, date = {2015-04-30}, urldate = {2015-04-30}, journal = {UK Journal of Pharmaceutical and Biosciences}, volume = {3}, issue = {2}, pages = {24-28}, abstract = {Pregnancy induced hypertension is a main cause of maternal mortality and morbidity . The aim of the present study was destined to evaluate the association of blood Rheology of complicated pre-eclampsia and its comparison with that in normal pregnancy and normal non-pregnant woman. The grouping was done as group I (normal, non-pregnant women) and group II (normal pregnant women) and group III (pregnancy with PIH) Mean age range was 20-35 years. Serum lipid profile, calcium and alkaline phosphatase were monitored in pre-eclampsia, normal pregnant and normal non-pregnant women. The normal pregnancy was associated with significant increase in HDL-cholesterol, VLDL-cholesterol, Triglyceride, Alkaline phosphatase, with no significant increase in T. cholesterol and significant decrease in LDL-cholesterol and serum calcium when compared to normal non pregnant woman. A significant rise of total cholesterol, triglyceride, LDL cholesterol, VLDL-cholesterol, Alkaline phosphatase and fall in HDL-cholesterol and serum calcium was observed with the pre-eclampsia when compared with normal and control groups. Decreased HDL cholesterol and delayed triglyceride clearance and high blood pressure are associated with development of pre-eclampsia and eclampsia, this association may be crucial for understanding the pathologic processes of pre-eclampsia and eclampsia and may helpful for prevention.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @article{Baldava_2015b, title = {Ocular colobamata in a family}, author = {Sheetal Baldava and Mutyala Gopal Kishan}, url = {https://www.jebmh.com/articles/ocular-colobamata-in-a-family.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-04-27}, urldate = {2015-04-27}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {17}, pages = {2634-2638}, abstract = {AIM: To identify the proportion of cases affected in a family with ocular colobamata. MATERIAL: Ocular colobomata present in a family METHOD: Visual acuity, Slit lamp examination, Ophthalmoscopy, Fundus Photography, B-Scan, Family members were examined. RESULTS: Family showed poor visual acuity, Iris and Choridal Coloboma without optic disc involvement and normal corneal diameter. CONCLUSION: Ocular coloboma occurring in patients of my study is family and genetically determined.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Kishan_2015, title = {X linked juvenile retinoschisis}, author = {Mutyala Gopal Kishan and Sheetal Baldava and S. S. Asadullah Hussain Saberi}, url = {https://www.jebmh.com/articles/x-linked-juvenile-retinoschisis.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-04-20}, urldate = {2015-04-20}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {16}, pages = {2460-2464}, abstract = {X linked juvenile retinoschisis is a rare genetic disorder affecting males. It is recessively inherited due to mutation in XLRS1 gene, localized to Xp22 region.(1) The characteristic funduscopic findings, are a silver-grey retinal reflex, fovealretinoschisis, and peripheral retinoschisis. Electroretinograms (ERGs) typically record reduced b-wave amplitude with relative preservation of the a-wave amplitude. Visual acuity (VA) usually deteriorates slowly until the patient is about 20 years of age, stabilises, and sometimes deteriorates further because of macular degeneration.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Kishan_2015c, title = {Sclerosing keratitis in reactivated systemic tuberculosis}, author = {Mutyala Gopal Kishan and Sheetal Baldava and Syed Musaab Mohiuddin}, url = {https://www.jebmh.com/articles/sclerosing-keratitis-in-reactivated-systemic-tuberculosis.pdf.pdf}, issn = { 2349-256}, year = {2015}, date = {2015-04-20}, urldate = {2015-04-20}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {16}, pages = {2438-2441}, abstract = {Interstitial Keratitis is non-ulcerating inflammation of the corneal stroma without the involvement of either epithelium or endothelium.(1) Keratitis in scleritis is either infiltrative or destructive. Infiltrative lesions present as localised or diffuse stromal keratitis, sclerosing keratitis or as deep keratitis. Sclerosing keratitis is known to be associated with rheumatoid arthritis,(2) onchocerciasis, tuberculosis(3) and other infective or auto immune diseases. We are reporting a case of sclerosing keratitis in a patient with reactivated tuberculosis. A 40 year old female patient presented with unilateral sclerosing keratitis and mild anterior uveitis with recent loss of weight and easy fatigability. She revealed a history of pulmonary tuberculosis in the past, for which she received Anti Tubercular Therapy for 6 months and was then declared cured at the time. A thorough workup for systemic risk factors was performed to evaluate etiological factors responsible for the keratitis and uveitis with special emphasis on tuberculosis. Though the blood work and radiology reports did not allow a definitive diagnosis of tuberculosis, in view of her past history, a therapeutic trial was initiated by restarting ATT. This resulted in improvement in her general condition. Though the corneal opacities didn’t resolve, there was an arrest in their progression. Over the next 8 months, the corneal lesions remained stable. An ocular event was the only obvious sign in this patient to indicate reactivation of systemic tuberculosis and it helped initiate treatment emphasizing the role of an ophthalmologist in early detection and prompt institution of treatment in systemic diseases.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Kishan_2015e, title = {Case of bilaterial anterior segment tuberculosis}, author = {Mutyala Gopal Kishan and Sheetal Baldava and Syed Khaleeluddin Aijaz}, url = {https://www.jebmh.com/articles/case-of-bilateral-anterior-segment-tuberculosis.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-04-20}, urldate = {2015-04-20}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {16}, pages = {2449-2452}, abstract = {Tuberculosis is an important cause of uveitis in our country. India has been declared the country with the highest tuberculosis burden with 25 % of the cases.(1) This is especially true in Andhra Pradesh and Telangana which have a high percentage of affected patients. However, tuberculous uveitis is usually a unilateral presentation. We report a case of bilateral uveitis of tuberculous origin in a 55 year old woman. She presented with different tuberculous manifestations in the two eyes. While the RE showed non granulomatous uveitis with sclerosing keratitis, the LE showed granulomatous uveitis with mutton fat keratic precipitates. Systemic examination revealed an enlarged lymph node which was positive for tuberculosis on biopsy. She was hence diagnosed as extra pulmonary tuberculosis and was treated with ATT regimen. In this patient, uveitis was the initial manifestation and resulted in a systemic diagnosis. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Kishan_2015b, title = {Profile of viral conjuctivitis}, author = {Mutyala Gopal Kishan and Sheetal Baldava and Jitha Vinay Reddy}, doi = {https://www.jebmh.com/articles/profile-of-viral-conjuctivitis.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-04-13}, urldate = {2015-04-13}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {15}, pages = {2296-2302}, abstract = {INTRODUCTION: Viral conjunctivitis is most commonly seen in the outpatient department. A variety of viruses which are responsible for conjunctival infection, of which Adenovirus is the most common. It is highly contagious during the first 2 weeks of infection. It can cause corneal involvement within 4-5 days after the onset of symptoms. Corneal lesions range from SPK (Superficial Punctate Keratitis) to epithelial defects. These corneal lesions may cause intense photophobia and impairment of vision. AIM: To find out the commonest etiological agent, to study the clinical features and complications related to it. METHODOLOGY: This study was carried out prospectively. 100 patients who came to outpatient department between October 2013 to October 2014 were enrolled in the study. All the age groups and both the genders were included. Patients underwent slit lamp examination and were diagnosed clinically. 25 cases were submitted for Gram staining and Polymerase Chain Reaction (PCR) study to know the type of virus and serotype. RESULT: 100 patients were diagnosed with viral conjunctivitis and were kept on follow up. 21percent of patients developed SPK. Adenovirus 8 was found to be more common than other viruses. CONCLUSION: The present study showed Adeno virus to be the most common etiological agent causing viral conjunctivitis and complications like subepithelial opacities and diminished vision.}, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Baldava_2015, title = {Pterygium excision in comparison of bare sclera technique and conjuctival autograft}, author = {Sheetal Baldava and Mutyala Gopal Kishan and Syeda Fatima Shabreen}, url = {https://www.jebmh.com/articles/pterygium-excision-in-comparison-of-bare-sclera-technique-and-conjuctival-autograft.pdf.pdf}, issn = {2349-2562}, year = {2015}, date = {2015-04-13}, urldate = {2015-04-13}, journal = {Journal of Evidence Based Medicine and Healthcare}, volume = {2}, issue = {15}, pages = {2256-2262}, abstract = {INTRODUCTION: Pterygium is a degenerative condition of the subconjuctival tissue which proliferates as vascularized granulation tissue to invade the cornea, destroying the superficial layers of the stroma and bowmans membrane. Surgical removal remains the main stay of treatment. OBJECTIVE: To compare the recurrence rate of bare sclera technique and conjuctival autografting in primary pterygium excision. METHODOLOGY: This study was carried out as a prospective comparative study. This study was conducted during June 2013 to June 2014. 50 patients of primary pterygium were admitted. 25 patients were treated with bare sclera technique and 25 patients were treated with conjunctival auto graft. Post-operative follow up was done for 6 months to find out the recurrence of pterygium and any other complications. RESULT: 25 patients received Bare Sclera Technique (n=25) and 25 patients received Conjunctival Auto Graft (CAG) (n=25). There was recurrence in 16 cases (40%) in group A with bare sclera technique and 2 cases (8%) had recurrence in GROUP B with conjunctival autograft. There was statistically significant difference in the recurrence rate in the 2 groups. Of other post-operative complications in bare sclera technique 5 cases (20%) had corneal opacity, 3 cases (12%) had scleral thinning, 5 cases (20%) had pyogenic granuloma. There was no significant post-operative complication with conjuctival auto graft. CONCLUSION: simple excision of pterygium followed by conjuctival autograft has the lowest recurrence rate and minimum incidence of complications compared to bare sclera technique. }, keywords = {Ophthalmology}, pubstate = {published}, tppubtype = {article} } @article{Naseem_2015, title = {Twenty nail dystrophy in 12-year-old male child: a case report}, author = {Altaf Naseem and Nayantara G. Rao}, url = {http://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_apr_cr15.pdf}, doi = {10.17354/ijss/2015/197}, issn = {2321-595X}, year = {2015}, date = {2015-04-01}, urldate = {2015-04-01}, journal = {International Journal of Scientific Study}, volume = {3}, issue = {1}, pages = {234-235}, abstract = {Twenty nail dystrophy of childhood or trachyonychia is a rare acquired disorder. It is usually idiopathic and can be associated with other diseases. It is characterized by excessive longitudinal ridging, brittleness and thickening of nail plates involving 1-20 nails. We report an interesting case of a 12-year-old adolescent boy who presented to us with rough, opaque and lusterless nails, without any systemic involvement. Histopathological examination revealed the typical spongiosis described with this disease. This report also highlights the rationale for a nail biopsy and challenges faced for investigation of the underlying cause. A conservative approach was successful in our patient.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Hussain_2015b, title = {Related deaths due to electrocution-a comparative study}, author = {Iqbal Banu Hussain and Mohd. Taquiddin Khan}, url = {https://www.cibtech.org/J-MEDICAL-SCIENCES/PUBLICATIONS/2015/Vol_5_No_1/21-JMS-22-ACCEPT-IQBAL-ELECTROCUTION.pdf}, issn = {2277-2103}, year = {2015}, date = {2015-04-01}, urldate = {2015-04-01}, journal = {International Journal of Basic and Applied Medical Sciences}, volume = {5}, issue = {1}, pages = {114-121}, abstract = {Deaths caused by Electrocution should be thoroughly documented and investigated for safety, prevention and compensatory reason. In the present study fatalities from electrocution and the related deaths are investigated. Preventive measures are suggested to bring down the fatal incidence in both Men and Women. The mechanism of Electrocution, Circumstances of Electrocution and investigation of electrocution deaths are described and mentioned in the present study.}, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Rao_2015, title = {Late infantile metachromatic leukodystrophy in a two year-old boy: a case report}, author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and S. Pratap Rao and B. Sugunakar Reddy}, url = {https://www.ijcasereportsandimages.com/archive/2015/004-2015-ijcri/CR-10501-04-2015-rao/ijcri-1050104201501-rao.pdf}, doi = {10.5348/ijcri-201540-CR-10501}, issn = {0976-3198}, year = {2015}, date = {2015-04-01}, urldate = {2015-04-01}, journal = {International Journal of Case Reports and Images}, volume = {6}, issue = {4}, pages = {228-232}, abstract = {Introduction: Metachromatic leukodystrophy (MLD) occurs due to cerebroside sulfatide accumulation in the extraneural and neural tissues. Arylsulfatase A (ARSA) enzyme deficiency leads to progressive focal or generalized demyelination. This rare disorder involves both central and peripheral nervous system. Case Report: We report a two-year-old boy, born of consanguineous marriage presenting with recurrent seizures from 13 months of age, followed by regression of milestones and spasticity from 15 months of age. Neurodegenerative disorder was considered initially and the child underwent neuroimaging followed by enzyme level assay. Magnetic resonance imaging scan (MRI) of brain revealed demyelination involving both cerebral cortex in the periventricular white matter with sparing of subcortical 'u' fibers and tigroid appearances /leopard skin sign, hallmark of metachromatic leukodystrophy. Normal β-galactosidase enzyme activity along with undetectable (ARSA) enzyme levels confirmed the diagnosis of late infantile variant of metachromatic leukodystrophy. Conclusion: A two-year-old boy presented with recurrent, generalized seizures, regression of milestones along with characteristic MRI findings and untraceable ARSA activity suggesting late infantile metachromatic leukodystrophy. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Mahmood_2015, title = {Liver cirrhosis with ascites: Study on identifying reliability parameters for clinical outcome}, author = {Shaikh Mahmood and Badruz Zama and Mohammed Abdul Hannan Hazari}, url = {https://www.ijpcbs.com/articles/liver-cirrhosis-with-ascites-study-on-identifying-reliability-parameters-for-clinical-outcome.pdf}, issn = {2249-9504}, year = {2015}, date = {2015-03-31}, urldate = {2015-03-31}, journal = {International Journal of Pharmaceutical, Chemical and Biological Sciences}, volume = {5}, issue = {1}, pages = {71-76}, abstract = {Background: Ascites is one of the major complications of liver cirrhosis which usually develop secondary to portal hypertension. Aim: The purpose of the current study was to evaluate the utility of ratios of few biochemical parameters between serum and ascetic fluid, whether these ratios are more reliable than the actual parameters in diagnosis and prognosis of these patients. Study design: Cross-sectional study. Place and duration of study: Owaisi Hospital and Research Centre, Hyderabad, India from July 2012 to December 2013. Methodology: Biochemical analysis of serum and ascetic fluid focussed on assessing liver function was done. A total of 350 cirrhotic patients of both genders were screened for ascites and 50 among them fulfilling inclusion and exclusion criteria were enrolled for this study. They were assessed for 34 demographic and laboratory parameters including liver function tests, renal function tests and serum electrolytes. We made an attempt to know whether ratio of some of the biochemical parameters in ascitic fluid-to-serum (AF/S) can be more reliable indicators and better prognostic markers in liver cirrhosis with ascites. Results and Conclusion: In this endeavour, the AF/S ratios of total proteins, albumin, ADA, LDH, GGT and α-amylase did not showed a clear advantage over the existing biochemical analysis in vogue.}, keywords = {Biochemistry, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Konuri_2015, title = {Evolution of automaticity of heart pacemaker studied from a theoretical perspective}, author = {Vijay Kumar Konuri and Mohammed Abdul Hannan Hazari and K. Ravi Kumar and M. Chandrasekhar and K. Ambareesha and Barra Ram Reddy}, url = {https://www.ijmrhs.com/abstract/evolution-of-automaticity-of-heart-pacemaker-studied-from-a-theoretical-perspective-163.html}, doi = {10.5958/2319-5886.2015.00077.6}, issn = {2319-5886}, year = {2015}, date = {2015-03-01}, urldate = {2015-03-01}, journal = {International Journal of Medical Research & Health Sciences}, volume = {4}, issue = {2}, pages = {417-421}, abstract = {The pacemaker of the mammalian heart had developed a robust and yet a flexible system in the course of evolution whose function is based on multiple interactions at the sub-cellular, cellular and finally at the tissue level. These, in turn, should respond to extrinsic signals. Cardiac action potentials were explained for a long time based on the changes that occur at the cell surface. New hypothesis was put forward at the turn of the century that pointed to the role of intracellular calcium clock. Discovery of ryanodine receptors, fluorescence labeling techniques, confocal imaging and finally computer modeling of physiological processes had brought about a noticeable change that allowed development of a new concept of pacemaker automaticity. Reviewing all these developments we hereby put forward a few theoretical formulations that can turn out to be new instruments in advancing our knowledge of cardiac physiology. We had theorized that cardiac muscle is an emergent property of smooth muscle in the course of evolution, and that pacemaker activity of the cardiac muscle underwent a phase transition that finally led to the evolution of a structural pacemaker.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Ravikiran_2015, title = {A rare case of maxillary sinus osteomyelitis with intraorbital, extraconal abscess in a term low birth weight twin}, author = {Janampally Ravikiran and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and Ekta Aggarwal and Anumula Soumya and Madhavi Nori}, url = {https://www.ijcasereportsandimages.com/archive/2015/003-2015-ijcri/CR-10485-03-2015-ravikiran/ijcri-1048503201585-ravikiran.pdf}, doi = {10.5348/ijcri-201524-CR-10485 }, issn = {0976-3198}, year = {2015}, date = {2015-03-01}, urldate = {2015-03-01}, journal = {International Journal of Case Reports and Images}, volume = {6}, issue = {3}, pages = {132-137}, abstract = {Introduction: Acute osteomyelitis in neonates is a rare infectious disorder of bone leading to diagnostic and therapeutic challenge, more so in neonates. While the long bones are frequently affected sites, maxilla is rarely involved. Physiological immaturity of the immune system coupled with invasive diagnostic and therapeutic procedures render them susceptible for this condition, more so in premature, low birth weight infants. The most common organism causing osteomyelitis in neonates is Staphylococcus aureus. Lesion of the orbit as well as contiguous faciomaxillary and sinonasal inflammatory pathology often lead to proptosis in neonates. Case Report: We report a 15-day-old term female neonate (twin 1) presenting with non-traumatic periorbital swelling and purulent nasal discharge. The neonate also had failure to thrive. On clinical examination, the neonate was sick with sclerema and shock. There was right eye proptosis with edema and erythema. Initial diagnosis of periorbital abscess or orbital tumor was considered and the infant was investigated. Sepsis screen was positive with marked polymorphic leukocytosis. Also, the blood culture and culture from sinus scraping grew Staphylococcus aureus. Magnetic resonance imaging scan of the brain including orbit revealed osteomyelitis of maxilla and intraorbital extraconal mass with restricted diffusion, suggesting intraorbital abscess. The neonate responded to intravenous antimicrobials and decompression of the abscess. Although, the source of this major infection is unidentified, low birth weight, failure to thrive and poor socioeconomic status might have contributed. Conclusion: We report a term, low birth weight, female neonate with culture positive sepsis, maxillary sinus osteomyelitis and orbital abscess. Osteomyelitis of the maxilla is a rare entity and an important etiological factor for orbital abscess.}, keywords = {Pediatrics, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Rani_2015, title = {Levels of upper limit of oxidative stress markers during normal pregnancy and pre-eclampsia}, author = {Damrela Usha Rani and Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari and R. Haragopal and Barra Ram Reddy}, url = {https://jmscr.igmpublication.org/home/index.php/archive/114-volume-3-issue-01-jan-2015#download-pdf-19}, issn = {2347-176X}, year = {2015}, date = {2015-01-31}, journal = {Journal of Medical Science and Clinical Research}, volume = {3}, issue = {1}, pages = {3674-3682}, publisher = {IGM Publication}, abstract = {Background: the reactive oxygen species (ROS) are involved in multiple reproductive processes – maturation of oocyte, fertilization, development of embryo, pregnancy and parturition. However, the optimal levels and interplay of oxidants and antioxidants is crucial for a positive pregnancy outcome. Pregnancy induced hypertension (PIH) is shown to have defective trophoblast invasion leading to high pressures in utero-placental circulation; thus this stress imposed on placenta may disturb the oxidant-antioxidant balance. Aim: the purpose of this study was to assess the oxidative stress during uncomplicated pregnancy and pregnancy associated with hypertension in primi-gravida women. Materials and methods: a total of 90 women were enrolled and divided into 3 groups. Group 1: Healthy non-pregnant women (n=30), Group 2: Normotensive primi-gravida women (n=30) and Group 3: Pre-eclamptic primi-gravida women (n=30). Blood samples were analyzed for levels of malondialdehyde (MDA), superoxide dismutase (SOD), total anti-oxidant capacity (TAC) and uric acid using appropriate biochemical methods. ANOVA was used for assessing the difference between the groups and statistical significance was fixed at p<0.05. Results: in the present study, levels of MDA, SOD and uric acid were significantly increased in pregnant compared to non-pregnant women and to a greater extent in pre-eclampsia women compared to normal pregnant women.TAC levels were significantly decreased in pregnant when compared to non-pregnant and much more decreased in pre-eclampsia women compared to normal pregnant women. Conclusion: high pressures in feto-placental circulation can lead to increased elaboration of oxidative radicals which may cause oxidative damage to placenta and other organs.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2015b, title = {Heterotaxy syndrome with associated agenesis of dorsal pancreas and polysplenia: a case report}, author = {Syed Althaf Ali and Syeda Naziya Parveen and Anand Abkari and G. S. N. Murthy and Ravindra Prakash Babu}, url = {https://www.ejmanager.com/mnstemps/154/154-1451052716.pdf}, issn = {2231-1696}, year = {2015}, date = {2015-01-31}, urldate = {2015-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {1}, pages = {10-13}, abstract = {Heterotaxy syndrome is a rare embryological disorder comprising of polysplenia, partial agenesis of dorsal pancreas, malrotation of gut, cardiac and vascular anomalies resulting from failure of development of the usual left–right asymmetry of organs. We report a rare case of heterotaxy syndrome with polysplenia, partial agenesis of dorsal pancreas and malrotation of gut in a 28 year female presenting with subacute intestinal obstruction along with imaging illustrations, brief discussion and thorough review of literature.}, keywords = {Anatomy, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2015c, title = {Cryoglobulin induced skin ulceration}, author = {Fatima Razvi}, url = {https://jmas.in/fulltext/154-1451055142.pdf?1698478102}, issn = {2231-1696}, year = {2015}, date = {2015-01-31}, urldate = {2015-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {5}, issue = {1}, pages = {21-23}, abstract = {Lupus Erythematosus (LE) is a multi-organ auto-immune disease which results from complex interaction of genetic and environmental factors. The clinical spectrum ranges from minor cutaneous lesions to life threatening multi-organ dysfunction. The skin manifestations are variable and common and range from LE specific to LE non-specific cutaneous disease. Vasculitis is one of the most common non-specific skin lesion of Systemic lupus erythematosus (SLE) and appears as purpuric lesions, infarcts along lateral nail folds, peripheral gangrene, sub-cutaneous nodules and ulcers. Mixed cryoglobulinaemia (type II) is associated with connective tissue disorders including SLE. Skin manifestations are seen in 60-100% patients and are more common in females. The most common manifestation is palpable purpura of lower extremities seen in 30-100% which often is triggered in winter or on cold exposure. Skin infarction, hemorrhagic crusts and ulcers are seen in 25% of patients. Wide spread necrotic ulcers are seen in 10-25% of patients which are often exacerbated by cold. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{Ali_2015, title = {MRI evaluation of developmental delay in pediatric patients}, author = {Syed Althaf Ali and Syeda Naziya Parveen and G. S. N. Murthy and Anand Abkari and B. K. Pooja and Jampala Venkateshwarlu}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347148/pdf/jcdr-9-TC21.pdf}, doi = {10.7860/JCDR/2015/11921.5478}, issn = {0973-709X}, year = {2015}, date = {2015-01-01}, urldate = {2015-01-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {9}, issue = {1}, pages = {TC21-TC24}, abstract = {Introduction: Developmental delay is defined as significant delay in one or more developmental domains. Magnetic Resonance Imaging (MRI) is the best modality to investigate such patients. Evaluation of a child with developmental delay is important not only because it allows early diagnosis and treatment but also helpful for parental counseling regarding the outcome of their child and to identify any possible risk of recurrence in the siblings. Thus this study was undertaken to evaluate the developmental delay in Indian children which will help the clinicians in providing an estimation of the child’s ultimate developmental potential and organize specific treatment requirement and also relieve parental apprehension. Aims and Objectives: To study the prevalence of normal and abnormal MRI in pediatric patients presenting with developmental delay and further categorize the abnormal MRI based on its morphological features. Materials and Methods: It is a prospective, observational & descriptive study of MRI Brain in 81 paediatric patients (46 Males and 35 Females), aged between three months to 12 years; presenting with developmental delay in Deccan College of Medical Sciences, Hyderabad; over a period of three years (Sept 2011 to Sept 2014). MRI brain was done on 1.5T Siemens Magnetom Essenza & 0.35T Magnetom C with appropriate sequences and planes after making the child sleep/sedated/ anesthetized. Various anatomical structures like Ventricles, Corpus callosum, etc were systematically assessed. The MRI findings were divided into various aetiological subgroups. Results: Normal MRI findings were seen in 32% cases and 68% had abnormal findings of which the proportion of Traumatic/ Neurovascular Diseases, Congenital & Developmental, Metabolic and Degenerative, neoplastic and non specific were 31%, 17%, 10%, 2.5% and 7.5% respectively. The ventricles and white matter mainly the corpus callosum were the most commonly affected anatomical structures. The diagnostic yield was found to be 68% and higher yield was seen in patients presenting with developmental delay plus. Conclusion: The clinical diagnosis of developmental delay should not be the end point, but rather a springboard for an effective search for causal factors. MRI is the best investigation with a high yield in such patients.}, keywords = {Anatomy, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2014, title = {Sinus histiocytosis and massive lymhadenaopathy (rosai-dorfman disease) in an 8 year old female child: a rare case report}, author = {Uppin Narayan Reddy and Swathi Chacham and Janampally Ravikiran and J. Narsing Rao and Jakkampudi Nagasravani and Abhijeet Ingle}, url = {https://www.ijmrhs.com/medical-research/sinus-histiocytosis-and-massive-lymphadenopathy-rosaidorfman-disease-in-an-8-year-old-female-child-a-rare-case-report.pdf}, doi = {10.5958/2319-5886.2015.00047.8}, issn = {2319-5886}, year = {2015}, date = {2015-01-01}, urldate = {2015-01-01}, journal = {International Journal of Medical Research & Health Sciences}, volume = {4}, issue = {1}, pages = {254-257}, abstract = {Introduction: Sinus histiocytosis with massive lymphadenopathy is an infrequent, self-resolving histo-proliferative disorder of benign nature, also known as Rosai–Dorfman Disease. The typical manifestation of this disease includes bilateral, progressive cervical lymphadenopathy along with pyrexia. Laboratory manifestations consist of raised erythrocyte sedimentation rate, leukocytosis and hypergammaglobulinemia. Case report: An 8 year old female child presented with progressive, painful cervical and submandibular lymphadenopathy of three months duration. There was polymorphic leukocytosis and anemia along with raised Erythrocyte sedimentation rate and hypergammaglobulinemia. Fine Needle Aspiration cytology revealed sinus histiocytosis with massive lymphadenopathy, which was confirmed by the cervical lymph node biopsy. The histopathology revealed dilated sinuses filled with lympho plasma cells, large histiocytes and engulfed neutrophils (Emperipolesis). Conclusion: Massive, progressive bilateral cervical and sub mandibular lymphadenopathy, suggesting Sinus histiocytosis and massive lymphadenopathy-Rosai–Dorfman Disease. This was confirmed by Cytology, histopathology and immuno-histochemistry.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2014d, title = {Comparative study of hand grip strength in rheumatoid arthritis patients and normal volunteers following yoga training}, author = {Farisa Khatoon}, url = {https://www.cibtech.org/J-LIFE-SCIENCES/PUBLICATIONS/2014/Vol-4-No-4/JLS-016-017-FARISA-COMPARATIVE-TRAINING.pdf}, issn = {2231-6345}, year = {2014}, date = {2014-12-31}, urldate = {2014-12-31}, journal = {Indian Journal of Fundamental and Applied Life Sciences}, volume = {4}, issue = {4}, pages = {97-99}, abstract = {The present study aimed at assessing the effect of a set of Yoga practices on patients of Rheumatoid Arthritis and normal adults. Equal number of normal subjects and patients of Rheumatoid arthritis who did not practice yoga were studied. Yoga and control group subjects were assessed at baseline and after varying intervals after 30 days. Hand grip of both the hands were assessed by grip dynamometer, increased in normaI and patients of Rheumatoid Arthritis following yoga session, but not in control group. Hence Yoga practice improves hand grip strength in normal and patients with rheumatoid arthritis, through magnitude of improvement varies with factors like age, gender.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2014b, title = {Cardiovascular collapse following intramyometrial injection of prostaglandin}, author = {Basheer Ahmed Khan and Vijaya Rekha Koti and Murtuza Khan and Syed Asrar Hussain and Mohammed Mohib Hussain and M. Aleemuddin Naveed}, url = {http://www.jcmad.com/admin/pdf/239a17.pdf}, doi = {10.18049/jcmad/239a17}, issn = {2347-4513}, year = {2014}, date = {2014-12-31}, urldate = {2014-12-31}, journal = {Journal of Contemporary Medicine and Dentistry}, volume = {2}, issue = {3}, pages = {80-82}, abstract = {A 21 year old female gravida 2, para 1, live 1 with previous lower segment cesaerian section (LSCS), hypothyroid on tablet Eltroxin 12.5mcg, was posted for LSCS. Spinal anaesthesia was given and the effect was patchy, hence general anaesthesia was supplemented. Intramyometrial prostaglandin was given by surgeon for persisting uterine atony following which patient developed hypertension, tachycardia, pulmonary edema and later on cardiac arrest.}, keywords = {Anesthesiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Parveen_2014, title = {Vertebral levels of great vessels in mediastinum and their role in vascular interventions}, author = {Syeda Naziya Parveen and Syed Althaf Ali and Imran S. Syed and Pritha S. S. Bhuiyan}, url = {https://www.ejmanager.com/mnstemps/67/67-1416002616.pdf}, doi = {10.5455/ijmsph.2015.1411201492}, issn = {2277-338X}, year = {2014}, date = {2014-12-03}, urldate = {2014-12-03}, journal = {International Journal of Medical Science and Public Health}, volume = {4}, issue = {4}, pages = {450-453}, abstract = {Background: The interventional procedures such as central venous catheterization demand better knowledge of anatomy of mediastinal vessels. The vertebral body provides a useful and radiographically visible landmark for accurate central catheter tip placement. Objective: To study the vertebral levels of formation and termination of superior vena cava (SVC) and the vertebral level of origin of brachiocephalic trunk, left common carotid artery, and left subclavian artery in Indian subjects, and to describe their role in vascular interventions. Materials and Methods: The CT chest images of 48 patients were studied and vertebral levels of earlier mentioned vessels were measured. Results: The vertebral level of formation of SVC was found to be at the level of T3, T4, and T5 in 22.91%, 62.50%, and 14.58% cases, respectively, whereas that of the termination of SVC was found to be at the level of T5, T6, T7, and T8 in 10.41%, 56.25%, 29.16%, and 4.16% cases, respectively. The left common carotid artery, left subclavian artery, and the brachiocephalic trunk were found at T3, T4, and T5 in 27.08%, 60.41%, and 12.50% cases, respectively. Conclusion: The comprehensive data of vertebral levels will help clinicians in understanding the vascular levels for diagnostic and therapeutic purposes, especially in Indian subjects.}, keywords = {Anatomy, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Vishwakarma_2014, title = {Preparation of natural three dimensional goat kidney scaffold for the development of bioartifical organ}, author = {Sandeep Kumar Vishwakarma and P. G. Bhavani and Avinash Bardia and Anand Abkari and G. S. N. Murthy and Jampala Venkateshwarlu and Aleem Ahmed Khan}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244717/?report=reader#__ffn_sectitle}, doi = {10.4103/0971-4065.133008}, issn = {0971-4065}, year = {2014}, date = {2014-12-01}, urldate = {2014-12-01}, journal = {Indian Journal of Nephrology}, volume = {24}, issue = {6}, pages = {372-375}, abstract = {The high prevalence of end-stage kidney diseases demands new treatment strategies. Decellularization approach may provide a viable option grow organs using a regenerative medicine approach. Goat kidney was decellularized by perfusion decellularization using detergents to produce an cellular construct for kidney scaffold. After pre-treatment with anticoagulant, the decellularized scaffold was analyzed for its intact three-dimensional natural architecture and vasculature. Perfusion of decellularized kidney preserved the structure and composition of renal extra-cellular matrix and vascular structures within the scaffold. No evidence of residual cellular components was found. This approach provides a model for understanding of whole organ regeneration.}, keywords = {Central Research Laboratory, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Parveen_2014c, title = {CT assessment of diameters of ascending and descending aorta in Indian subjects}, author = {Syeda Naziya Parveen and Syed Althaf Ali and Imran S. Syed and Anand Abkari and G. S. N. Murthy}, url = {https://ijcrr.com/uploads/702_pdf.pdf}, issn = {0975-5241}, year = {2014}, date = {2014-12-01}, urldate = {2014-12-01}, journal = {International Journal of Current Research and Review}, volume = {6}, issue = {23}, pages = {59-62}, abstract = {Background: An enlargement of the aortic diameter exceeding at least 50% of the normal range results in aneurysm formation. Endovascular stent grafting is a newer form of treatment for thoracic aortic aneurysms that is less invasive than open surgery and has the success rate around 95%. The ratio of stent graft size to aortic diameter should be of the order of 1.1–1.15; higher diameters have to be avoided in order to limit the vessel wall stretch which may result in antegrade or retrograde dissection or perforation. After reviewing the literature thoroughly, it was found that even though the diameter of ascending and descending aorta has a wide range of clinical implications and applications, there is dearth of literature pertaining to the quantitative measurements of the diameters of ascending and descending aorta in Indian subjects. Aim: • To measure the diameter of ascending aorta (DOAA) and diameter of descending aorta (DODA) at the level of pulmonary artery bifurcation in Indian subjects using computed tomography. • To establish the upper normal limits of DOAA and DODA; to rule out aneurysm of thoracic aorta. Materials and Method: The CT chest images of 76 patients (44 males and 32 females) were studied. The DOAA and DODA were measured at the level of pulmonary artery bifurcation; across a line joining the ascending and the descending aorta. Results: 1. The average DOAA was 33.44 mm ± 1.12 mm in males and 31.43 mm ± 1.52 mm in females; the upper normal limits of DOAA were 35.68 mm for males and 34.47 mm for females. 2. The average DODA was 25.11 mm ± 1.34 mm in males and 23.04 mm ± 1.58 mm in females; the upper normal limits of DODA were 27.79 for males and 26.20 for females. Conclusion: A quantitative assessment of the diameters of ascending and descending aorta has been presented which will help the clinicians for diagnostic and therapeutic purpose especially in Indian subjects.}, keywords = {Anatomy, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Ravi_2014, title = {Comparative study of primary closure versus open technique after excision of sacrococcygeal pilonidal sinus}, author = {Ganji Ravi and Jaheer Abbas Shaik and Satyanarayana Ravula and Sujit Kumar Vakati R. and Sonia Sharma}, url = {https://www.journalijar.com/uploads/536_IJAR-4407.pdf}, issn = {2320-5407}, year = {2014}, date = {2014-11-30}, urldate = {2014-11-30}, journal = {International Journal of Advanced Research}, volume = {2}, issue = {11}, pages = {480-483}, abstract = {Aims & objectives: To study and compare the efficacy of the primary closure and open technique after excision of sacrococcygeal pilonidal sinus. Methods &Materials: A comparative study was designed and 61 patients with sacrococcygeal pilonidal sinus were included in this study. This study took place in Owaisi hospital and research centre for a period of three years. The patients were separated into two groups. Group A (31 patients) were treated by open method (excision & healing by secondary intention) and group B (30 patients) for whom primary closure (by different types of closure techniques aiming at lateralization of natal cleft)done after excision of pilonidal sinus. The follow-up ranged from 4months to 1.5years with mean follow up of 11months was throughout patient visits. Results: Out of 31 patients in group A 20 were males and 11 were females, in group B 22 were males and 8 were females. Group A patients with mean age of 24 ± 7 years and group B with mean age of 25 ± 8 years. In group A9 patients presented with complications and all were wound infections, in groupA 5 patients presented with complications 3 with wound dehiscenceand2 with wound infection. Recurrence was seen in only one patient in group B and in none in group A. Conclusion: Excision and primary closure of sacrococcygeal pilonidal sinus aiming at lateralization of natal cleft is superior to excision and healing by secondary intention. }, keywords = {General Surgery}, pubstate = {published}, tppubtype = {article} } @article{Bardia_2014, title = {Mental health conditions: a mini review}, author = {Avinash Bardia and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan and Arifuddin Ahmed and Ramakrishna Podaralla}, url = {http://www.recentscientific.com/sites/default/files/1735.pdf}, issn = {0976-3031}, year = {2014}, date = {2014-11-28}, urldate = {2014-11-28}, journal = {International Journal of Recent Scientific Research}, volume = {5}, issue = {11}, pages = {2086-2088}, abstract = {Mental illness is common. Anxiety and depression are the most general troubles, with around 1 in 10 people affected at any one time. Anxiety and depression can be severe and long-lasting and have a big impact on people’s ability to get on with life. These review pay attention on special research methods to give an insight into various gene and protein expression, neuroplasticity and neurotransmission, as well as many other areas. The aim of this review to summarize the available data on the depression and suicide, to provide an overview of main research directions and the most up-to-date findings, and to indicate the possibilities of further research in this field.}, keywords = {Central Research Laboratory, Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Maaz_2014, title = {Training in the use of inhalation devices and respiratory improvement in asthma and COPD patients: A before-after experimental study}, author = {Mohammed Maazuddin and Mohammed Abdul Hannan Hazari and Ashfaq Hasan and Mohd. Javeedullah and Mohd. Nasir Mohiuddin and Mirza Misba Ali Baig}, url = {https://www.researchgate.net/publication/272944333_Training_in_the_use_of_inhalation_devices_and_respiratory_improvement_in_asthma_and_COPD_patients_A_before-after_experimental_study}, issn = {2231-0541}, year = {2014}, date = {2014-11-01}, journal = {PHARMANEST}, volume = {5}, issue = {5}, pages = {2314-2320}, abstract = {Objective: The aim of the study was to assess the effectiveness of one-time personalized intervention by pharmacists in the form of training in correct inhaler technique. Methods: 104 asthma and COPD patients attending the out-patient department Pulmonary Medicine of a medical college hospital in Hyderabad were recruited for the study. At two different visits, patients were assessed for their respiratory status, importance of treatment and inhaler technique. After assessment at the first visit, patients were given one-time health education about the disease and the correct inhaler technique was demonstrated by hospital based pharmacists. Comparisons were made between the two visits for respiratory status using St. George’s Respiratory Questionnaire. We used students‘t’ test for comparing the results. Results: There was reduction in SGRQ scores irrespective of the device used which shows the effectiveness of one-time health education and training. The changes in SGRQ scores were found to be statistically significant with all devices except with use of Rotahaler and Starhaler. Conclusion: Inhalation technique of patients is usually poor regardless of the device prescribed, and educational intervention with the demonstration of the sequential steps involved in particular inhaler results in significant improvement in inhalational technique. Intervention by hospital based pharmacists proved more effective than the verbal instructions given in the physician’s consultation room. Therefore, sufficient time should be devoted for a practical demonstration of inhaler technique after prescribing.}, keywords = {Deccan School of Pharmacy, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Parveen_2014b, title = {A computerised tomographic study of normal mediastinal anatomy in Indian subjects}, author = {Syeda Naziya Parveen and Syed Althaf Ali and Pritha S. S. Bhuiyan and Imran S. Syed and Anand Abkari and G. S. N. Murthy}, url = {https://www.ijhsr.org/IJHSR_Vol.4_Issue.11_Nov2014/17.pdf}, issn = {2249-9571}, year = {2014}, date = {2014-10-17}, urldate = {2014-10-17}, journal = {International Journal of Health Sciences and Research}, volume = {4}, issue = {11}, pages = {111-116}, abstract = {Background: The mediastinum is a complex region, containing vital structures. The details of the spatial relations of these structures can be studied with the help of cross sections at various vertebral levels. Computerised Tomography (CT) is the best way to explore this region in living subjects. The advent of minimal access surgeries like mediastinoscopy demand better knowledge of anatomy. This pioneering study will be of immense help in understanding the living anatomy of mediastinal structures especially in Indian subjects. Aim: To study the vertebral levels of sternal angle and tracheal bifurcation and to measure the dimensions of mediastinum in Indian subjects. Materials and Method: CT chest of 48 patients were studied and dimensions of mediastinum and vertebral levels of sternal angle and tracheal bifurcation of mediastinum were measured. Results: 1. The vertebral level of sternal angle passed through T5 in 68.75% cases. 2. The vertebral level of tracheal bifurcation was seen at T5 in 52.08% cases and at and below T6 in 31.25% cases. 3. The average anteroposterior diameter of mediastinum was 59.69 ± 3.99 mm in males and 49.74 ± 3.2 mm in females. 4. The average transverse diameter of mediastinum was 55.62 ± 2.18 mm in males and 49.83 ± 2.94 mm in females. Conclusion: The above comprehensive data of mediastinal dimensions will help clinicians in understanding the mediastinal anatomy for diagnostic and therapeutic purpose especially in Indian subjects.}, keywords = {Anatomy, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Chacham_2014, title = {Epidermolysis bullosa in a small for gestational age preterm male neonate with two affected siblings: a case report}, author = {Swathi Chacham and Jakkampudi Nagasravani and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao and A. S. Kumar}, url = {https://www.ijcasereportsandimages.com/archive/2014/010-2014-ijcri/CR-10433-10-2014-chacham/ijcri-1043310201433-chacham.pdf}, doi = {10.5348/ijcri-2014122-CR-10433}, issn = {0976-3198}, year = {2014}, date = {2014-10-01}, urldate = {2014-10-01}, journal = {International Journal of Case Reports and Images}, volume = {5}, issue = {10}, pages = {691-694}, abstract = {Introduction: Epidermolysis bullosa is a rare group of hereditary disorders, which are characterized by blistering of the skin and mucosa due to little or no apparent trauma. The severity can range from mild, localized skin blisters to generalized, systemic life-threatening disease and the treatment is mainly supportive. Dystrophic type of epidermolysis bullosa is one of the rarer forms. Skin fragility often leads to secondary skin infections and in turn generalized infection which can be lethal. Hence, the major challenge encountered in the care of a neonate with epidermolysis bullosa is optimum skin care and expert nursing care. A preterm, small for gestational age (SGA) neonate, has immature skin physiologically, which is a portal for systemic infection when compared to a term appropriate for gestational age neonate. The presence of blistering lesions in a preterm, SGA neonate further challenges the management. Case Report: We report a preterm, low birth weight (small for gestational age) male neonate, who had extensive bullous lesions and dystrophic nails in the first week of life. These lesions healed by scarring leading to stiffness of underlying joints and were complicated by secondary infection. There was history of consanguinity and previous two siblings also had similar lesions with contractures. Conclusion: A preterm male small for gestational age neonate born of consanguineous marriage, with the history of cutaneous bullous lesions in two siblings, presented with extensive bullous lesions and dystrophic nails, suggestive of dystrophic epidermolysis bullosa. }, keywords = {Dermatology, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2014c, title = {Tactile sensitivity in the visually challenged and normal subjects – a comparative study}, author = {Farisa Khatoon}, url = {https://www.cibtech.org/J-Medical-Case-Reports/PUBLICATIONS/2014/Vol-3-No-3/JCR-022-021-FARISA-TACTILE-STUDY.pdf}, issn = {319–3832}, year = {2014}, date = {2014-09-30}, journal = {Indian Journal of Medical Case Reports}, volume = {3}, issue = {3}, pages = {67-71}, abstract = {Blindness defined as visual activity less than 3/60 by Snellen’s chart or its equivalent. The present study shows that there is definitely superior capacity of tactile sensitivity in blind people compared with sighted people. The tactile task like discrimination, recognition, shape and size are more superior in visually challenged than compared to normal sighted subjects. The present study demonstrates that the primary submodalities of somatic sensations (touch, pain, temperature and vibratory sense) in visually challenged are similar to those of sighted person.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2014, title = {A 3 year old female child with type 1 sturge weber syndrome: a case report}, author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Naila Mazher and Afreen Mahmood and Jakkampudi Nagasravani}, url = {https://www.saspublishers.com/article/7699/}, doi = {10.36347/sjmcr.2014.v02i09.009}, issn = {2347-6559}, year = {2014}, date = {2014-09-29}, urldate = {2014-09-29}, journal = {Scholars Journal of Medical Case Reports}, volume = {2}, issue = {9}, pages = {605-608}, abstract = {Sturge-Weber Syndrome (SWS) is a neuro-cutaneous disorder characterized by angiomas of face and the central nervous system. These angiomas, are the hallmark of SWS. While other phacomatoses are hereditary in nature, SWS occurs sporadically and with a frequency of 1 in 50,000. Mutations in GNAQ gene result in altered structure and innervation of cerebral vasculature. A three year old female child presented with recurrent seizures from infancy. General physical examination revealed several hyper-pigmented macules over the trunk and both lower limbs. A purple coloured port wine stain was found on the right side of the face. Imaging (Contrast enhanced CT) of the brain showed extensive pial enhancement in the right parieto-occipital lobe. MRI brain depicted ipsilateral enlargement of choroid plexus, characteristic finding of Sturge weber syndrome. We report a rare case of type 1 SWS with ipsilateral choroid plexus enlargement and typical pial enhancement.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Sainath_2014, title = {Occupational health hazards in sewage and sanitary workers}, author = {C. Sainath and Khazi Mudabbir Ahmed}, url = {https://www.ijbamr.com/assets/images/issues/pdf/September%202014%2031-35.pdf.pdf}, issn = {2250-284X}, year = {2014}, date = {2014-09-15}, urldate = {2014-09-15}, journal = {Indian Journal of Basic and Applied Medical Research}, volume = {3}, issue = {4}, pages = {31-35}, abstract = {An estimated 1.2 million scavengers in the country are involved in the sanitation of our surroundings. The working conditions of these sanitary workers have remained virtually unchanged for over a century. Apart from the social atrocities that these workers face, they are exposed to certain health problems by virtue of their occupation. These health hazards include exposure to harmful gases such as methane and hydrogen sulfide, cardiovascular degeneration, musculoskeletal disorders like osteoarthritic changes and intervertebral disc herniation, infections like hepatitis, leptospirosis and helicobacter, skin problems, respiratory system problems and altered pulmonary function parameters. This can be prevented through engineering, medical and legislative measures. While the engineering measures will help in protecting against exposures, the medical measures will help in early detection of the effects of these exposures. This can be partly achieved by developing an effective occupational health service for this group of workers. Also, regular awareness programs should be conducted to impart education regarding safer work procedures and use of personal protective devices. }, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @inbook{nokey, title = {Obstructive sleep apnea and the metabolic syndrome: Clinical profiles and relationships}, author = {Ashfaq Hasan and Nazia Uzma and Bhaskarpillai Santhosh Kumar}, editor = {Ronald Ross Watson}, url = {https://www.elsevier.com/books/modulation-of-sleep-by-obesity-diabetes-age-and-diet/watson/978-0-12-420168-2}, isbn = {9780128103074}, year = {2014}, date = {2014-09-14}, urldate = {2014-09-14}, booktitle = {Modulation of sleep by obesity, diabetes, age, and diet}, pages = {139-147}, publisher = {Academic Press}, edition = {1st}, chapter = {16}, keywords = {Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {inbook} } @article{Khatoon_2014b, title = {Cardiovascular and ventilatory response during virasana}, author = {Farisa Khatoon}, url = {https://www.cibtech.org/J-MEDICAL-SCIENCES/PUBLICATIONS/2014/Vol_4_No_2/JMS-068-082-FARISA-CARDIOVASCULAR.pdf}, issn = {2277-2103}, year = {2014}, date = {2014-08-31}, journal = {International Journal of Basic and Applied Medical Sciences}, volume = {4}, issue = {2}, pages = {380-382}, abstract = {Ventilatory and Cardiovascular responses to Yogic standing posture are studied in 50 healthy Nursing Female Students. The results of various responses in chair setting are during Virasana are observed. Virasana Postures are characterized by increase in MVV, TV and Heart rate. This suggest temporary hyper metabolic state characterized by increase in sympathetic activity, increased respiratory function which gets stimulated by chair sitting posture.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khatoon_2014a, title = {Incidence of hypertension in urban and rural population}, author = {Farisa Khatoon}, url = {https://www.cibtech.org/J-MEDICAL-SCIENCES/PUBLICATIONS/2014/Vol_4_No_2/JMS-067-080-FARISA-INCIDENCE-POPULATION.pdf}, issn = {2277-2103}, year = {2014}, date = {2014-08-31}, journal = {International Journal of Basic and Applied Medical Sciences}, volume = {4}, issue = {2}, pages = {370-379}, abstract = {Hypertension is an important public health challenge in both economically developing and developed countries Measures are required at a population level to prevent the development of hypertension and to improve awareness, treatment and control of hypertension in the community. Recent studies among Indians have shown a high prevalence of hypertension in both urban and rural areas. The effects of B.M.I., B.S.A. and W.H.R. on the S.B.P., D.B.P. and M.A.P. have been proved in the present study in both urban and rural populations in both sexes in the age group of 20 – 60 years. Increased incidence of silent hypertension in the urban males and females compared to rural males and females can be noticed from the present study.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2014d, title = {Impact of maternal risk factors on the incidence of low birth weight (LBW neonates in Southern India)}, author = {Uppin Narayan Reddy and A. Vamshee Priya and Swathi Chacham and Sana Salim Khan and J. Narsing Rao and Mohd. Nasir Mohiuddin}, url = {https://www.ijmrhs.com/medical-research/impact-of-maternal-risk-factors-on-the-incidence-of-low-birth-weightneonates-in-southern-india.pdf}, doi = {10.5958/2319-5886.2014.00006.X}, issn = {2319-5886}, year = {2014}, date = {2014-08-15}, urldate = {2014-08-15}, journal = {International Journal of Medical Research & Health Sciences}, volume = {3}, issue = {4}, pages = {813-818}, abstract = {Introduction: Birth weight is recommended as one of the twelve global indicators for monitoring the health of the community and is an important determinant of adverse perinatal and neonatal events. LBW infant carries five times higher risk of dying in the neonatal period and three times more in infancy. Aims and Objectives: To estimate the incidence of LBW and impact of various maternal and biosocial factors on the incidence of LBW neonates in the study population. Material and methods: This prospective observational study was carried out in Princess Esra hospital, a tertiary care hospital in south India, over a period of six months. All consecutive LBW (single ton) neonates admitted to the neonatal intensive care unit were enrolled, while those born of multiple gestation and those with major congenital malformations were excluded. Results: A total of 300 neonates were included in the present study out of which 150 were LBW and 150 weighed ≥2500 gm. Higher maternal weight (>60kgs) had low incidence of LBW neonates (p value-0.03). Illiterate women had a remarkably higher incidence of LBW babies (p value-0.001). In primigravida incidence of LBW was 61.2%. Higher incidence of LBW was seen in mothers with oligo hydramnio’s. Conclusions: This study showed that maternal age, weight, literacy level and parity have a significant influence on the incidence of LBW. Incidence of LBW neonate in the study was 50%. Risk of having LBW neonates was higher in primigravida. There was a significant association between LBW with oligo hydramnio’s and female gender. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Mahmood_2014, title = {A five year old male child with late infantile metachromatic leukodystrophy- a case report}, author = {Afreen Mahmood and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao}, url = {https://journals.sagepub.com/doi/10.1177/0883073814542948}, doi = {10.1177/0883073814542948}, issn = {1708-8283}, year = {2014}, date = {2014-08-12}, urldate = {2014-08-12}, journal = {Journal of Child Neurology}, volume = {30}, issue = {4}, pages = {483-485}, abstract = {Metachromatic leukodystrophy is a rare disorder of myelin metabolism. This degenerative disorder results from the accumulation of cerebroside sulfatide within the myelin sheath of central and peripheral nervous system, due to deficiency of aryl sulfatase A enzyme. We report a 5-year-old male child, who presented with regression of milestones, recurrent seizures and spasticity from second year of life. Initially neurodegenerative disorder was considered and the case was investigated with neuroimaging and enzyme levels. Computed tomography (CT) of the brain showed hypodensities in the corpus callosum and bilateral periventricular and deep cerebral white matter suggestive of neurodegenerative disorder. Subsequently, magnetic resonance imaging (MRI) of the brain was done, which showed symmetrical hyperintensities in the periventricular white matter with classical sparing of subcortical “U” fibers. The β-galactosidase enzyme activity was normal; however, the activity of aryl sulfatase A enzyme was undetectable, confirming the diagnosis of late infantile variant of metachromatic leukodystrophy.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{David_2014, title = {Does teaching experience influence personality types and teaching styles of faculty in a medical college}, author = {M. Anthony David Swaroop Kumar and Mehnaaz Sameera Arifuddin and Farah Bahmed and Mohammed Abdul Hannan Hazari and Syed Azherullah Quadri and Samreen Fathima and Hassan Bin Ali}, url = {https://www.researchgate.net/publication/267040515_Does_teaching_experience_influence_personality_types_and_teaching_styles_of_faculty_in_a_medical_college}, year = {2014}, date = {2014-07-31}, journal = {International Journal of Health and Education}, volume = {3}, issue = {1}, pages = {56-62}, abstract = {The aim of this study was to determine if there is any influence of teaching experience on personality types and teaching styles of faculty members in a medical college. A total of 35 teachers of pre- and para-clinical departments of a medical college participated in this study. Their personality types and teaching styles were determined using appropriate questionnaires. Their experience in years of teaching was used to divide them into 2 groups; Group 1: with less than and equal to 5 years and Group 2: more than 5 years teaching experience. Analyses were done using appropriate statistical methods. The study shows that the percentage of teachers who have extroverted personality type with an expert style of teaching is more in Group 2 when compared to Group 1. Experience, expertise and appropriate teaching styles might help in bettering medical education in general.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2014, title = {High Mallampati score, obesity and obstructive sleep apnea: Triple insult to lung function?}, author = {Nazia Uzma and Ashfaq Hasan and Bhaskarpillai Santhosh Kumar}, url = {https://jmas.in/?mno=211790}, issn = {2231-1696}, year = {2014}, date = {2014-07-31}, urldate = {2014-07-31}, journal = {Journal of Medical and Allied Sciences}, volume = {4}, issue = {2}, pages = {69-72}, abstract = {The paper assesses the combined effect of high Mallampati score, obesity and obstructive sleep apnea (OSA) on lung function as measured by spirometry. Our results showed that the combination of sleep apnea, obesity and high Mallampati score resulted in a degree of restriction that was significantly greater than that produced by each factor alone. These observations underscore the importance of factoring in the Mallampati score in the assessment of respiratory disease.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2014b, title = {Congenital rubella syndrome with basal ganglia calcification and bilateral nuclear cataracts in a neonate: a rare entity}, author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Jakkampudi Nagasravani and Naila Mazher and Syed Taha Mustafa}, url = {https://www.saspublishers.com/article/7648/}, doi = {10.36347/sjmcr.2014.v02i07.015}, issn = {2347-6559}, year = {2014}, date = {2014-07-29}, urldate = {2014-07-29}, journal = {Scholars Journal of Medical Case Reports}, volume = {2}, issue = {7}, pages = {470-472}, abstract = {In-utero transmission of rubella virus during pregnancy leads to congenital Rubella syndrome (CRS), which is characterized by cataracts, deafness and sensorineural hearing loss. While the nuclear cataract is the most frequently occurring abnormality, basal ganglia calcification is a rarer manifestation. The Risk of fetal transmission of rubella virus is highest during the first 12 weeks of gestation and decreases afterwards. A 36weeks, 2600grams male neonate was born by vaginal delivery with normal APGARS. The neonate was admitted on third day of life with complaints of yellowish discoloration of the skin and sclera. On examination, the neonate had mild hypotonia, icterus up to the legs and systolic murmur on cardiac examination. Interestingly, the ophthalmological examination revealed bilateral nuclear cataracts. Chest radiograph showed cardiomegaly and ECHO revealed PDA (Patent Ductus Arteriosus). Hence, CRS was suspected and further evaluation was done. There was thrombocytopenia, mild unconjugated hyperbilirubinemia with mild elevation of transaminases. Another rare finding was basal ganglia calcification on neurosonogram. TORCH profile in both mother and baby showed elevated rubella IgM levels confirming CRS. The neonate received supportive and symptomatic treatment. We report a preterm, male appropriate for gestational age neonate with congenital rubella syndrome and its rare manifestation of basal ganglia calcification.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Nagasravani_2014, title = {A rare case of ataxial telangiectasia in a nine year old female child}, author = {Jakkampudi Nagasravani and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao and Afreen Mahmood}, url = {https://www.pedneur.com/article/S0887-8994(14)00399-3/fulltext}, doi = {10.1016/j.pediatrneurol.2014.06.022}, issn = {0887-8994}, year = {2014}, date = {2014-07-15}, urldate = {2014-07-15}, journal = {Pediatric Neurology}, volume = {51}, issue = {4}, pages = {583-584}, abstract = {Ataxia telangiectasia (A-T) is a rare multisystemic disorder with autosomal recessive inheritance. It is characterized by oculocutaneous telangiectasia, recurrent sinopulmonary infections, and neurodegeneration manifesting as ataxia. Progressive immunodeficiency and radiation-induced chromosomal breakage are hall marks of A-T. It has genetic and clinical heterogeneity, and the responsible gene (ATM gene) is located at chromosome 11q22-23. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2014, title = {Baroreceptor and chemoreceptor reflex contribution in cardiovascular changes during exercise}, author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Ayesha Farheen and Irshad Hussain Askari}, url = {https://www.researchgate.net/publication/267985135_Baroreceptor_and_Chemoreceptor_Reflex_Contribution_in_Cardiovascular_Changes_during_Exercise}, doi = {10.5958/2320-608x.2014.00009.2}, issn = {2320-6039}, year = {2014}, date = {2014-07-01}, urldate = {2014-07-01}, journal = {International Journal of Physiology}, volume = {2}, issue = {2}, pages = {36-41}, publisher = {Institute Medico-legal Publication}, crossref = {Hazari_2014}, abstract = {During exercise, both baroreceptors and chemoreceptors contribute in bringing about the cardiovascular changes, but less is documented about the contribution made by either of these mechanisms. The purpose of the present study was to demonstrate the differential effects of baroreceptors and chemoreceptors on cardiovascular parameters during exercise. Twelve healthy individuals were subjected to exercise maneuver on stationary cycling machine. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and electrocardiogram (ECG) were recorded during rest and immediately after exercise. Heart rate (HR) and heart rate variability (HRV) was computed from ECG. SBP, DBP, mean arterial blood pressure (MABP) and HR significantly increased due to exercise. Increase in SBP, DBP, Pulse pressure (PP), MABP and HR were more pronounced when chemoreceptor influence was not considered as against when changes due to both baroreceptors and chemoreceptors were considered. The HRV analysis reflected increase in the low-frequency (LF) power % and decrease in high-frequency (HF) power % along with reduction in LF/HF ratio due to exercise, but these changes were statistically not significant. Baroreceptors through baroreflex mechanism overall increase the CVS parameters. The novel finding in this study was the opposing action of chemoreceptor mechanism to that of baroreceptor mechanism in cardiovascular homeostasis during exercise. }, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hazari_2014b, title = {Integrated teaching in medical curriculum in India}, author = {Mohammed Abdul Hannan Hazari}, url = {https://www.researchgate.net/publication/267987893_Integrated_teaching_in_medical_curriculum_in_India}, doi = {10.18035/emj.v2i3.170}, issn = {2307-7301}, year = {2014}, date = {2014-07-01}, urldate = {2014-07-01}, journal = {El Mednifico Journal}, volume = {2}, issue = {3}, pages = {314}, publisher = {El Mednifico Journal}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Pasha_2014, title = {Acute retention of urine a rare presentation of type 2 diabetes mellitus (DM): a case report}, author = {Ather Akhtar Pasha and Suhail Bin Ahmed}, url = {http://www.ijpmbs.com/uploadfile/2015/0412/20150412044114144.pdf}, issn = {2278-5221}, year = {2014}, date = {2014-07-01}, urldate = {2014-07-01}, journal = {International Journal of Pharma Medicine and Biological Sciences}, volume = {3}, issue = {3}, pages = {80-83}, abstract = {Abstract—Diabetes Mellitus is causing a big socioeconomic burden in developing countries. Inadequate education and awareness about disease and its complication has further added to existing scenario particularly in India. Common clinical features of Diabetes Mellitus include polyuria, polydipsia and weight loss, nonhealing skin infection. Here we report an unusual case of Diabetes Mellitus presenting as acute retention of urine due to prostatic abscess, which completely recovered with conservative treatment, highlighting complete evaluation, early diagnosis, treatment and prevention of complications.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Pasha_2014b, title = {Role of low dose hydrocortisone in the management of viral thrombocytopenia}, author = {Ather Akhtar Pasha and Suhail Bin Ahmed}, url = {http://www.ijpmbs.com/uploadfile/2015/0412/20150412043958821.pdf}, issn = {2278-5221}, year = {2014}, date = {2014-07-01}, urldate = {2014-07-01}, journal = {International Journal of Pharma Medicine and Biological Sciences}, volume = {3}, issue = {3}, pages = {95-97}, abstract = {Thrombocytopenia is very common presentation of acute febrile illness. Mostly they are viral in etiology like dengue fever. The white blood cells respond by producing a number of signaling proteins, such as cytokines and interferon's, which are responsible for many of the symptoms, such as the fever, the flu-like symptoms and the severe pains. In severe infection, the virus production inside the body is greatly increased, and many more organs (such as the liver and the bone marrow) can be affected. Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to capillary permeability. As a result, less blood circulates in the blood vessels, and the blood pressure becomes so low that it cannot supply sufficient blood to vital organs. Furthermore, dysfunction of the bone marrow due to infection of the stromal cells and peripheral destruction of platelets in spleen leads to reduced numbers of platelets, which are necessary for effective blood clotting; this increases the risk of bleeding, the other major complication of dengue fever. The use of low dose corticosteroids helps in stopping the ongoing immune destruction of platelets and hence avoiding platelet transfusion and its associated complications and overall its cost effectiveness in the management of viral thrombocytopenia in Indian scenario.}, keywords = {General Medicine}, pubstate = {published}, tppubtype = {article} } @bachelorthesis{Jyothsna_2014, title = {A rare case report of anhidrotic ectodermal dysplasia in a newborn}, author = {B. Jyothsna and S. Pratap Rao and Mir Sumsam Ali Khurram and Janampally Ravikiran and Diggireddy Shilpa Reddy and Uppin Narayan Reddy}, url = {https://www.saspublishers.com/article/7628/}, doi = {10.36347/sjmcr.2014.v02i06.018}, issn = {2347-6559}, year = {2014}, date = {2014-06-30}, urldate = {2014-06-30}, journal = {Scholars Journal of Medical Case Reports}, volume = {2}, issue = {6}, pages = {408-410}, abstract = {Ectodermal Dysplasias are a heritable group of disorders characterized by faulty development of two or more tissues derived from embryonic ectoderm. This disorder primarily involves skin, hair, nails, teeth and eccrine glands. The disease is usually diagnosed in late infancy and childhood but early diagnosis in a newborn baby tends to have good prognosis. We report a rare case of Anhidrotic Ectodermal Dysplasia in a 26 day old Newborn baby presenting with recurrent episodes of fever, hypotrichosis and anhydrosis.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {bachelorthesis} } @article{Altaf_2014, title = {Cost-effectiveness analysis of combined inhaled corticosteroids and bronchodilators for severe and very severe COPD patients in a teaching hospital}, author = {Mohammed Altaf and Ayesha Mubeen Zubedi and Fareesa Nazneen and Shaik Kareemulla and Syed Amir Ali and Mirza Misba Ali Baig and Arshad Hussain Mohd and M. Aleemuddin Naveed and Mohammed Abdul Hannan Hazari and Syed Abdul Azeez}, url = {http://iosrphr.org/papers/v4i06/Part_2/C04602012023.pdf}, doi = {10.9790/3013-040602012023}, issn = {2250-3013}, year = {2014}, date = {2014-06-30}, urldate = {2014-01-01}, journal = {IOSR Journal of Pharmacy (IOSRPHR)}, volume = {4}, issue = {6}, pages = {12-23}, publisher = {IOSR Journals}, crossref = {Altaf_2014}, abstract = {BACKGROUND: This study aims at simplifying the practical patient management and offers some general indications for pharmacotherapeutic choice by the implementation of (GOLD 2004) guidelines. This study was designed to evaluate the clinical and economic consequences of Salmeterol/Fluticasone(SF), Formoterol/Budesonide(FB) and Formoterol/Fluticasone(FF) in severe and very severe COPD patients. OBJECTIVES: To find out the most cost-effective drug combination between the three combinations (SF/FB/FF) in COPD patients. METHODS: A Prospective observational Comparative study (Cost-effectiveness Analysis) in which 90 severe (30≤FEV1<50% predicted) and very severe (FEV1<30% predicted) COPD patients (OP/IP) who are prescribed with any one of the following combinations (SF/FB/FF) were selected. In our study we have divided 90 COPD patients into 3 groups (Group I, Group II & Group III) each group consisting of 30 patients. Group I was prescribed with medication SF (salmeterol/fluticasone), Group II with medication FB (formoterol/budesonide) and Group III with medication FF (formoterol/fluticasone). We used five different parameters such as Spirometry test (mean FEV1 initial & final visit), Number of symptom free days, Number of moderate & severe exacerbations and Direct, indirect & total cost to assess the cost-effectiveness of SF/FB/FF. Comparison of cost and effects was done during the period of 6 months of using SF/FB/FF. RESULTS: The average FEV1 for group I, group II and group III subjects at initial visit was 33.47%, 33.73% & 33.20% and was increased to 36.60%, 35.8% and 33.4% respectively. A 3% increment in FEV1 was reported for group I subjects (SF) and was highly significant statistically (t=-8.833}, keywords = {Deccan School of Pharmacy, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2014b, title = {A rare case of buphthalmos and bilateral nuclear cataracts in a neonate with congenital rubella syndrome}, author = {Uppin Narayan Reddy and Swathi Chacham and J. Narsing Rao and A. Vamshee Priya and Afreen Mahmood and Jakkampudi Nagasravani and Mohd. Ahmedulla Khan}, url = {https://www.jemds.com/data_pdf/swathi%20chacham.pdf}, doi = {10.14260/jemds/2014/2847}, issn = {2278-4748}, year = {2014}, date = {2014-06-23}, urldate = {2014-06-23}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {3}, issue = {25}, pages = {6965-6969}, abstract = {BACKGROUND: Congenital rubella syndrome (CRS) is the second leading cause of non‐traumatic childhood cataracts in India. While nuclear cataract is the most common abnormality reported in CRS, congenital glaucoma is a rarer manifestation. CASE REPORT: A 34weeks low birth weight, male neonate was born by vaginal delivery with normal APGARS. The neonate had sparse hypo pigmented hair over the scalp, along with hypopigmented eye brows and eye lashes. There were erythematous lesions over palms, soles and groin region. Eye examination revealed bilateral nuclear cataracts along with buphthalmos. The neonate also had clinical manifestations of PDA, which was confirmed by 2-D Echo. Systemic involvement was seen as hepatosplenomegaly and bilateral cryptorchidism. Hence CRS was suspected and further evaluation was done. There was thrombocytopenia, mild unconjugated hyperbilirubinemia with elevated transaminases. Neurosonogram was normal and there were no intra cranial calcifications. TORCH profile in both mother and baby showed elevated rubella IgM levels confirming CRS. The neonate received supportive and symptomatic treatment. DISCUSSION: congenital nuclear cataracts are reported in 60-80% of CRS, while buphthalmos is rarely seen, more so in neonatal period. PDA occurs in 50% of CRS and two-thirds have hepatosplenomegaly. Rubelliform rash is infrequent in neonates with CRS. CONCLUSION: We report a preterm low birth weight, male neonate with congenital rubella syndrome and its rare manifestations. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2014, title = {A cross-sectional study of plasma pseudocholinesterase and it's correlation to mortality among organophosphorous poisoning patients}, author = {Khazi Mudabbir Ahmed and C. Sainath and Parvez Ahmed}, url = {https://www.ijbamr.com/assets/images/issues/pdf/285-291.pdf.pdf}, issn = {2250-284X}, year = {2014}, date = {2014-06-22}, urldate = {2014-06-22}, journal = {Indian Journal of Basic and Applied Medical Research}, volume = {3}, issue = {3}, pages = {285-291}, abstract = {Introduction: Organophosphorus poisoning is the most common medico toxic emergency in India. Respiratory failure is the most common complication of OP compound leading to death. Early recognition and prompt ventilation may improve survival. The aim of the study was to correlate between the clinical score described by Peradenya Organophosphorus Poisoning (POP) scale, serum pseudocholinesterase level at presentation, ventilator requirement and the outcome. Methods: Patients of OP poisoning attending Owaisi Hospital from Jan 2013 to Dec 2013 were studied. Sixty Four patients fulfilled the inclusion criteria. Fifty one of them required ventilator support. Twelve of them succumbed. None of the non ventilated patients died. Clinical scoring by Peradenya scoring and serum pseudocholinesterase level was measured in all patients. Results: The severity of poisoning as measured by POP scale directly correlated with serum cholinesterase level (P<0.001). There were 50% patients in moderate poisoning score and only 5% patients in severe poisoning. A total of 18% of the patients died of which 85% belonged to moderate and severe group. POP scale directly correlated with death outcome (P<0.001). It was also seen that all the patients with pseudo cholinesterase level less than 50% of normal range were ventilated. Lower Pseudo cholinesterase level also directly correlated to death outcome (P<0.001). Conclusion: The POP scale and serum cholinesterase at presentation appeared useful to assess the severity of poisoning, particularly in terms of need for ventilator and prolonged duration of hospital stay. }, keywords = {Forensic Medicine}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2014c, title = {A rare case of Griscelli's syndrome with review of literature}, author = {Uppin Narayan Reddy and J. Narsing Rao and Swathi Chacham and Afreen Mahmood and Jakkampudi Nagasravani}, url = {https://jemds.com/data_pdf/Afreen%20Mahmodd.pdf}, doi = {10.14260/jemds/2014/2831}, issn = {2278-4748}, year = {2014}, date = {2014-06-17}, urldate = {2014-06-17}, journal = {Journal of Evolution of Medical and Dental Sciences}, volume = {3}, issue = {25}, pages = {6874-6877}, abstract = {INTRODUCTION: Griscelli syndrome is a rare autosomal recessive disorder characterized by partial albinism and immunodeficiency. The characteristic features include silver hair due to clumped melanosomes in hair shaft. Other features include hepatospleenomegaly, hepatitis, pancytopenia and immune abnormalities. CASE REPORT: A seven years old male child presented with partial albinic features and history of recurrent respiratory tract infection. The child had fever since 2months along with hepatospleenomegaly, pancytopenia and thrombocytopenic purpura. These rare clinical manifestations were diagnosed as GS which was confirmed by bone marrow biopsy and light microscopy of hair shaft. The mean patient age of survival is 5years. As early diagnosis can improve the outcome in such cases, a finding of partial albinism should alert the diagnosis of Griscelli’s syndrome. CONCLUSION: We report a rare case of GS with characteristic manifestation surviving beyond the mean age of reported survival. }, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2014, title = {Study of treatment interruption of new sputum smear positive TB cases under DOTS strategy}, author = {Sultan Rizwan Ahmad and Gajanan D Velhal}, url = {https://www.bibliomed.org/mnsfulltext/67/67-1399283328.pdf?1693292675}, doi = { 10.5455/ijmsph.2014.050620141}, issn = {2277-338X}, year = {2014}, date = {2014-06-05}, urldate = {2014-06-05}, journal = {International Journal of Medical Science and Public Health}, volume = {3}, issue = {8}, pages = {977-981}, abstract = {Background: In 1993 GoI launched RNTCP and adopted DOTS-Strategy, to revitalize the TB control programme in India. Aims & Objective: This study attempts to find out the prevalence and reasons for non-adherence /non-compliance to DOTS. Materials and Methods: Community based prospective observational study was conducted with 281 newly diagnosed sputum positive TB cases. The follow-up sputum examination, interruption from treatment and reasons for non-adherence details were obtained at the end of the 2nd, 4th & 6th month for sputum smear negative TB cases and 5th & 7th month for sputum smear positive TB cases. Results: Study shows 25% of the cases did not report for follow up sputum smear examination after intensive phase and 50% of the cases at the end of follow up. Main reasons for not attending the follow-up sputum smear examination were lack of awareness (45%) and workload (31%). During the treatment period, 28 % were interrupted in intensive phase and 40% interrupted in continuation phase and 29% were defaulters. The reasons for treatment interruption were adverse effects (39%), lack of personal interest (27%) and work load (27%). Treatment interruption was more in age group of 0-50 years (74.87%), male (74.54%), illiterate (77.38%) and labourers (75.32%). Conclusion: Noncompliance was found to be mainly due to lack of unawareness, lack of time, side effects of medicines, which can be modified by IEC and focus service delivery on high risk groups.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Khan_2014, title = {Infantile Pompes disease in a female neonate with significant family history: a case report}, author = {Sana Salim Khan and Swathi Chacham and S. Pratap Rao and Uppin Narayan Reddy and J. Narsing Rao}, url = {https://www.saspublishers.com/article/7602/}, doi = {10.36347/sjmcr.2014.v02i05.008}, issn = {2347-6559}, year = {2014}, date = {2014-05-29}, urldate = {2014-05-29}, journal = {Scholars Journal of Medical Case Reports}, volume = {2}, issue = {5}, pages = {333-335}, abstract = {Pompes disease is a rare metabolic myopathy of autosomal recessive inheritance. It is caused by the deficiency of lysosomal enzyme acid alpha-glucosidase, which results in lysosomal and cytoplasmic glycogen accumulation. A wide spectrum of disease exists, varying from hypotonia and severe hypertrophic cardiomyopathy in infancy, to a milder form which manifests in adulthood. In either condition, the involvement of several systems leads to progressive weakness and disability. We report a six month old female infant who presented with hypotonia, developmental delay and hypertrophic cardiomyopathy. Significantly elevated CPK and LDH levels coupled with reduced acid α glucosidase activity, confirmed the diagnosis of Infantile Pompes disease. This infant had recurrent respiratory infections, failure to thrive and succumbed to death, due to hypertrophic cardiomyopathy at one year of age. The younger sibling was a carrier for pompes disease and there was a family history of hypertrophic cardiomyopathy.}, keywords = {Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Anjum_2014, title = {Assessment of parental understanding of pediatric medical prescriptions}, author = {Sadiqua Anjum and Mohd. Nasir Mohiuddin and Uppin Narayan Reddy and J. Narsing Rao and Sana Afreen and Mir S. Adil and Mohd. Javeedullah}, url = {https://www.ijmrhs.com/medical-research/assessment-of-parental-understanding-of-paediatric-medical-prescriptions.pdf}, doi = {10.5958/2319-5886.2014.00393.2}, issn = {2319-5886}, year = {2014}, date = {2014-05-21}, urldate = {2014-05-21}, journal = {International Journal of Medical Research & Health Sciences}, volume = {3}, issue = {3}, pages = {541-546}, abstract = {Medical prescriptions are bound to be misinterpreted by patients and pharmacists if not properly conveyed. Pediatric prescriptions differ from adult prescriptions having wide variation in doses and formulations.There is a need to evaluate the lacunae in the parental understanding of pediatric prescriptions.Aims and objective: To evaluate the parental understanding ofpediatric prescription and to evaluate the adequacy of communication with the physician and pharmacist regarding the same.Material and methods: 550 parents were enrolled and their literacy level was noted.They were subjected to modify MUSE questionnaire.Physician’s prescription was analyzed in terms of ease of understanding by parents. These parents were followed up till the pharmaciesand the pharmacist understanding of prescription was analyzed and their communication with parents regarding drug usage was noted. Finally, ease of usage of drugs by parents was noted. Results:MUSE scale was modified to suit pediatric prescription understanding by parents and also additional questions were asked to include complete parental understanding of doctor’s prescription. Majority of parents failed to completely understand the written prescription. Though around 80% of pharmacist could understand the prescription, their communication with parents was poor resulting in difficulty for parents to even enquire about medicines from them. Parental overall understanding of prescription increased with their literacy levels. Conclusion:Not all prescriptions are completely understood by parents as well as a pharmacist. This can lead to misuse of drugs. Efforts to explain the drug usage are not adequate enough from the doctor or the pharmacist. While communicating literacy levels of parents is not being considered which may further worsen the understanding ability.}, keywords = {Deccan School of Pharmacy, Pediatrics}, pubstate = {published}, tppubtype = {article} } @article{Bahmed_2014, title = {Impact of seminars by and for medical students}, author = {Farah Bahmed and M. Anthony David Swaroop Kumar and Mehnaaz Sameera Arifuddin}, url = {http://nicpd.ac.in/ojs-/index.php/njirm/article/view/712}, issn = {2230-9969}, year = {2014}, date = {2014-04-30}, urldate = {2018-01-01}, journal = {National Journal of Integrated Research in Medicine}, volume = {5}, issue = {2}, pages = {103-106}, abstract = {Background: The undergraduate medical program is a 5 year academic course wherein Physiology is taught in the first professional year. Physiology is nowadays a subject of clinical interest. It provides the basis to understand physiological processes and phenomena and thus the pathophysiology of disease. It also helps the students understand the basis for therapeutics and the management of diseases. The faculty of the Physiology department has a greater responsibility in making the study of the subject innovative, interesting and participatory, for the students. One such method we have adopted is organizing seminars by the students and for the students. Aim &amp;amp; objectives: This study aims to gauge the impact of student seminars on students who participated as well as on those who were spectators. Materials and methods: Students were encouraged to volunteer for taking seminars. They were given help by faculty to study and present small subtopics for about 10 minutes each. Later they were analyzed and statistical tests were done. Results: There was a positive response from both the participants and the spectators for the use of student seminars as a method of teaching/learning. Conclusions: Student seminars were discovered to be a good method of teaching learning which improved the depth of learning, teacher-student and student-student interactions and communication skills amongst the students participating. This was evident from the feedback obtained from the students.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Naveed_2014, title = {A cross-sectional study on prescribing patterns on patients suffering from respiratory disorders in a teaching hospital of South India}, author = {M. Aleemuddin Naveed and Farah Bahmed and Mohammed Shakeel Mohammed Bashir and Syed Amir Ali and Salma Khatoon and Md. Mohib Hussain and Afshan Khatoon}, doi = {10.18049/jcmad/213}, issn = {2347-4513}, year = {2014}, date = {2014-04-30}, urldate = {2014-04-30}, journal = {Journal of Contemporary Medicine and Dentistry}, volume = {2}, issue = {1}, pages = {12-17}, keywords = {Deccan School of Pharmacy, Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2014, title = {Does the teaching performance of faculty in Physiology change over the years?}, author = {Mehnaaz Sameera Arifuddin and Farah Bahmed and M. Anthony David Swaroop Kumar and Mohammed Abdul Hannan Hazari}, url = {https://eduimed.usm.my/EIMJ20140601/EIMJ20140601_09.pdf}, doi = {10.5959/eimj.v6i1.183}, issn = {2180-1932}, year = {2014}, date = {2014-03-01}, urldate = {2014-03-01}, journal = {Education in Medicine Journal}, volume = {6}, issue = {1}, pages = {e56-e61}, publisher = {Penerbit Universiti Sains Malaysia}, keywords = {Medical Education Unit, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Ahmed_2014b, title = {Psychological evaluation of couples attending the infertility clinic in a tertiary care, teaching hospital}, author = {Arifuddin Ahmed and Nusrath Fathima and Sandeep Kumar Vishwakarma and Aleem Ahmed Khan and Ramakrishna Podaralla and Rene De Souza and Roya Rozati}, url = {http://www.ijcrar.com/vol-2-2/Arifuddin%20Ahmed,%20et%20al.pdf}, issn = {2347-3215}, year = {2014}, date = {2014-02-01}, urldate = {2014-02-01}, journal = {International Journal of Current Research and Academic Review}, volume = {2}, issue = {2}, pages = {133-147}, abstract = {Psychological evaluation of couples attending the infertility clinic in a tertiary care, teaching hospital were used to study the prevalence of anxiety, depression and the effect of infertility on the quality of life of infertile couples. Reproductive failure or involuntary childlessness is a significant loss for men and women worldwide. Psychopathological response is not a universal consequence in infertile couples. The data from India is very sparse and far. Although infertility is primarily a medical condition its diagnosis can greatly impact the emotional functioning of the couples and/or individuals dealing with the problem. The study was conducted from among the couples attending the infertility counseling clinic from August 2006 to October 2008 in Hyderabad. 50 couples were recruited into the study according to the inclusion and exclusion criteria and were administered after a diagnosis of anxiety and/or depression by the attending psychiatrist. The prevalence of mild to moderate anxiety was 76% in the recruited females suggesting that the prevalence of anxiety is higher in infertile couples and more so in the female groups who attempted infertility treatment at least once. The prevalence of mild to moderate depression was about 66% and for moderate to severe was about 37% in the recruited males as opposed to 26% and 74% in the recruited females. The prevalence of severe anxiety and depression was higher in infertile couples and more so in the female spouse (upto 4 years of marriage). }, keywords = {Central Research Laboratory, Obstetrics & Gynecology, Psychiatry}, pubstate = {published}, tppubtype = {article} } @article{Anees_2014, title = {Evaluation of oxidative stress and antioxidant status in relation to glycemic control in Type 1 and Type 2 diabetes mellitus}, author = {Syyeda Anees and Parveen Naimath and Mohammed Siraj and Mohammed Ishaq}, url = {https://docsdrive.com/pdfs/academicjournals/ajbmb/2014/93-98.pdf}, doi = {10.3923/ajbmb.2014.93.98}, issn = {2150-4210}, year = {2014}, date = {2014-01-01}, urldate = {2014-01-01}, journal = {American Journal of Biochemistry and Molecular Biology}, volume = {4}, issue = {2}, pages = {93-98}, abstract = {Oxidative stress and antioxidant status was evaluated in relation to glycemic control in Type 1 and 2 Diabetes Mellitus patients (DM). A total of 69 DM patients (34 T1 and 35 T2DM cases) were enrolled in the study along with 15 healthy subjects. The patients were grouped into those with good glycemic control and others with poor glycemic control. Serum fructosamine levels were also determined as a supportive parameter for confirming glycemic status. Serum Malondialdehyde (MDA) level was used as a marker of oxidative stress and serum catalase activity was quantitated for an assessment of anti-oxidant status of the patients. Mean MDA levels in poor glycemic control group of T1 and T2DM were significantly higher (p<0.01) not only than the means of the healthy controls but also than the means of diabeteic groups with good glycemic control (p<0.01). Mean serum catalase activity was significantly reduced in DM patients of all the groups compared to that of healthy controls (p<0.05) indicating considerable reduction in the anti-oxidant status of the patients. }, keywords = {Biochemistry, Central Research Laboratory, General Medicine}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2014, title = {Estimation of glycated hemoglobin in Type 2 diabetes mellitus}, author = {Tahmeen Jameel and Syed Mahmood Ahmed }, url = {https://www.cibtech.org/J-Innovative-Research-Review/Publications/2014/Vol-2-No-1/JIRR-05-010-TAHMEEN-ESTIMATION-MELLITUS.pdf}, issn = {2347-4424}, year = {2014}, date = {2014-01-01}, urldate = {2014-01-01}, journal = {International Journal of Innovative Research and Review}, volume = {2}, issue = {1}, pages = {29-34}, abstract = {The study on measurement of glycated haemoglobin levels serves as an important index in the diagnosis of diabetes and also monitoring of diabetes patients to prevent the complications. The cause of diabetic complication is not known. Major emphasis has been placed on the polyol pathway where in glucose is reduced to sorbitol by the enzyme aldose reductase with reduced NADPH as the electron donating coenzyme. Sorbitol molecule is oxidised to fructose by the enzyme sorbitol dehydrogenase and reduced NAD+. Sorbitol appears to function as a tissue toxin and has been implicated in pathogenesis of retinopathy, neuropathy, cataract and aortic diseases. A second mechanism of potential pathogenetic importance is glycation of proteins. Glycation is non enzymatic addition of hexoses to proteins and glycosylation is enzymatic addition. This chemical reaction is the linkage between a reducing sugar and a receptive amino acid. It was first described in relation to food proteins (Millard, 1913). It has been shown that the difference in ionic charge between HBA1c and ordinary adult haemoglobin was due to addition of a glucose molecule to the amino terminal valine of the beta chain via an aldimine linkage which then underwent an Amadori rearrangement to form a more stable and virtually irreversible ketamine product (Bookchin, 1968; Bunn, 1975). The logical culmination of these findings was the hypothesis that in diabetes the level of glycosylated haemoglobin HBA1c or HBA1 would be proportional to the time averaged blood glucose level in the previous 7-8weeks, a period approximating to the half life of the average red blood cells. Normal glucose produces a normal amount of glycated haemoglobin. In diabetes mellitus higher amount of glycated haemoglobin indicates poorer control of blood glucose level. Fasting plasma glucose and glycated haemoglobin was estimated and based on the results the subjects were classified into three groups. Group I: Normal control non diabetic subjects; Group II: DM with good glycaemic control; Group III: DM with poor glycaemic control; Group II and group III patients were evaluated for complications by including lipid profile, tests for protein in urine and fundus examination. It was found that one or more complications were more predominant in Group III than in group II subjects. }, keywords = {Biochemistry, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Ahmad_2013, title = {Study of treatment outcome of new sputum smear positive TB cases under DOTS strategy}, author = {Sultan Rizwan Ahmad and Gajanan D Velhal}, url = {https://www.ijpbs.net/abstract.php?article=MjY1Mw==}, issn = {0975-6299}, year = {2013}, date = {2013-09-01}, urldate = {2013-09-01}, journal = {International Journal of Pharma and Bio Sciences}, volume = {4}, issue = {3}, pages = {1215-1222}, abstract = {Background: In India every year, 1.8 million new cases of TB occur, of which about 0.8 million are sputum positive pulmonary TB cases. This study attempts to find out the treatment outcomes of smear positive cases and factors that affect the outcome. Methodology: Community based prospective observational study was conducted in urban slums of Mumbai. Total 281 newly diagnosed sputum smear positive TB cases were selected, followed-up, and treatment outcome was obtained within 1 month after completion of continuous phase of treatment. Results: Tuberculosis is common among the illiterates (nearly 60 %) and labourers (53%), people below poverty line (90%), living in overcrowded houses (75%). In the present study, 42.7% were cured, 24.56% were treatment completed, 8.19% had died, and 4.98% were failure and 19.57% were defaulters after treatment. The cure rates and treatment completion were comparatively better in the age groups of 0-49 years (44.50 & 26.7%) and among females (53.85% &32.31%). Defaulter, Death and failure are more in labourer (22.78%, 9.49 %& 7.59%) and illiterates (26.79%, 10.71% & 6.55%). Cure rates and treatment completion are low among smokers (39.1% & 21.85%) and tobacco chewer (29.73% & 16.22%). Conclusion: Lower cure rates and high defaulters are found to be associated with illiteracy and smoking, which can be modified by IEC and focus service delivery on high risk groups.}, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{Nori_2013, title = {Extrahepatic biliary atresia with choledochal cyst: prenatal MRI predicted and post natally confirmed: a case report}, author = {Madhavi Nori and Jampala Venkateshwarlu and Vijaysekhar and G. Raghavendra Prasad}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843332/pdf/IJRI-23-238.pdf}, issn = {0971-3026}, year = {2013}, date = {2013-08-31}, urldate = {2013-08-31}, journal = {Indian Journal of Radiology and Imaging}, volume = {23}, issue = {3}, pages = {238-242}, abstract = {Extrahepatic biliary atresia (EHBA) is an uncommon cause of neonatal jaundice. Antenatal Magnetic Resonance Imaging (MRI) diagnosis of EHBA has not been published to the best of our knowledge till date. EHBA with cystic component is likely to be mistaken for choledochal cyst. A case that was antenatally predicted and postnatally confirmed by surgery and histopathology is being reported. All imaging signs are analyzed herewith. Imaging helps in the prediction of EHBA and also helps in early postnatal surgical referral which in turn improves the results of Kasai’s portoenterostomy.}, keywords = {Pediatric Surgery, Radiodiagnosis}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2013b, title = {Neural modulation of inflammation}, author = {Mehnaaz Sameera Arifuddin and K. Sai Krishna and Mohammed Abdul Hannan Hazari and B. Dinesh Kumar}, url = {http://www.jbpr.in/index.php/jbpr/article/view/712}, issn = {2279-0594}, year = {2013}, date = {2013-06-28}, journal = {Journal of Biomedical and Pharmaceutical Research}, volume = {2}, issue = {3}, pages = {109-113}, abstract = {Background: In the present situation of emerging cases of drug allergies, auto-immune disorders and adverse reactions to anti-inflammatory drugs, there is a need to find an alternative for handling abnormal immune status which causes inflammatory storm. There is a growing need to exploit the nervous system for understanding the role played by neurons in the inflammatory process. Aims and objectives: The purpose of this study was to understand the anti-inflammatory role of parasympathetic nervous system using Bethanechol chloride and to study the contribution of neurons in modulating inflammation using 2% Carrageenan. Materials and methods: Thirty female Wistar (WNIN) rats were selected for this study. Twenty five WNIN rats, divided into five groups were selected for studying the anti-inflammatory activity of Bethanechol chloride. The remaining five rats were selected to elicit the inter-dependent natures of immune and nervous systems. 2% Carrageenan was injected in both the hind paws. In both the study protocols, increase in paw volume was measured using plethysmometer and subjected to calculations. Results: A significant anti-inflammatory activity of Bethanechol chloride compared to control group was observed. In the other part of study, the right paw, in which Carrageenan re-constituted in Lidocaine was injected, showed nearly no signs of inflammation in the initial hours, while left paw injected with Carrageenan dissolved in distilled water presented with a typical Carrageenan-induced paw oedema. However, one to two hours later (which corresponds to the half-life of Lidocaine), the right paw also showed the same degree of oedema. Conclusion: We conclude that Bethanechol chloride has anti-inflammatory activity at small doses, and therefore can be used as an adjuvant in the treatment of chronic inflammatory disorders. This study also shows that immune system works in conjunction with the nervous system in modulating inflammation.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2013, title = {Variant formation of median nerve-A review of literature}, author = {Battula Sadananda Rao and Vasanta Leela}, url = {https://www.ijpbs.net/abstract.php?article=MjMwMA==}, issn = {0975-6299}, year = {2013}, date = {2013-06-01}, urldate = {2013-06-01}, journal = {International Journal of Pharma and Biosciences}, volume = {4}, issue = {2}, pages = {669-672}, abstract = {Anatomical variations of median nerve are frequent. Anomalies of the brachial plexus and its terminal branches are also common. An extra lateral root was observed arising from the lateral cord of brachial plexus, in the left axilla of a male cadaver during the course of undergraduate gross anatomy dissections. This anomalous root had a very oblique course over the axillary artery. The application and significance of our finding vis-à-vis current research in basic & clinical medicine, is discussed.}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Khan_2013, title = {Waist-hip ratio as the predictor of hypertension in obese males}, author = {Mohd. Inayatullah Khan and Khan Tabassum Tanweer and Mudassir Mirza and Farah Bahmed}, issn = {2347-4513}, year = {2013}, date = {2013-04-30}, journal = {Journal of Contemporary Medicine and Dentistry}, volume = {1}, issue = {1}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @inbook{Paspala_2013, title = {Pluripotent stem cells for neural regeneration}, author = {Syed Ameer Basha Paspala and Aleem Ahmed Khan and Sandeep Vishwakarma and T. V. Ramakrishna Murthy}, editor = {Michael K. Danquah and Ram I. Mahato}, url = {https://link.springer.com/chapter/10.1007/978-1-62703-417-3_16}, doi = {10.1007/978-1-62703-417-3_16}, isbn = {9781627034173}, year = {2013}, date = {2013-04-17}, urldate = {2013-01-01}, booktitle = {Emerging Trends in Cell and Gene Therapy}, pages = {347-371}, publisher = {Humana Press}, chapter = {16}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {inbook} } @article{Rao_2013b, title = {TVUS for endometrial thickness-and review of literature}, author = {Battula Sadananda Rao and Vasanta Leela}, url = {https://www.rjpbcs.com/pdf/2013_4(2)/[41].pdf}, issn = {0975-8585}, year = {2013}, date = {2013-04-01}, journal = {Research Journal of Pharmaceutical, Biological and Chemical Sciences}, volume = {4}, issue = {2}, pages = {381-388}, abstract = {Monthly cyclical changes in the uterine endometrium can be followed excellently by sonography, particularly when close range magnification with high resolution imaging is done by Transvaginal Ultrasonography [TVUS]. Hormonal changes are reflected in the endometrial histology from proliferative phase to secretory phase, as the endometrium reflects the functioning ability of the hypothalamo-pituito-ovarian axis. The study of different endometrial patterns of TVUS may be utilized in the diagnosis of pathological conditions like endometriosis, malignancy, tuberculosis of endometrium, &, importantly, infertility. The aim of this study is to determine the endometrial thickness in women of all age groups from menarche to menopause, and its correlation with the period of menstrual cycle. The values obtained from standard pre-clinical subject texts, and referenced clinical texts have differed, and we therefore reviewed a wide variety of publication sources to get a better co-relation for our findings. Reported values, other investigative methods, and the significance of this modality, are discussed. Key words : trans-vaginal ultrasound, endometrial thickness, cyclical variation in endometrium}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2013, title = {Effects of age and gender on cognitive functions as assessed by p300 potentials}, author = {Mehnaaz Sameera Arifuddin and Keerthana Kota and Mohammed Abdul Hannan Hazari and Barra Ram Reddy}, url = {https://www.biomedscidirect.com/journalfiles/IJBMRF20131071.pdf}, issn = {0976-6685}, year = {2013}, date = {2013-03-31}, journal = {International Journal of Biological and Medical Research}, volume = {4}, issue = {1}, pages = {2910-2914}, abstract = {Background: Higher mental functions decline as age advances, sometimes leading to overt dementia which compromises an individual's day-to-day activities. Contrary to this, some elderly individuals show remarkable intellectual capabilities, which drive our attention to the factors apart from age that are detrimental to cognitive functions. Gender is an important factor that needs to be considered while assessing cognitive functions. Aims and objectives: The aim of the present study was to interpret the pattern of cognitive decline with respect to age and to compare the difference in cognitive potentials among males and females. Materials and methods: The study was conducted on 61 apparently healthy subjects. Subjects were divided into 5 sub-groups based on age(Group I: 16-25 years, Group II: 26-35 years, Group III: 36-45 years, Group IV: 46-55 years and Group V: 56-65 years). The p300 cognitive potentials were recorded using Nicolet Viking Select (Viasys Healthcare, U.S.A.). Results: The p300 latencies exhibited increasing trend and p300 amplitudes showed decreasing trends in the consecutive age groups. However, the change between the consecutive age groups was statistically not significant. Also, in the corresponding age groups, there was no significant difference between males and females. Conclusions: The increasing trend in the p300 latencies indicate subtle decline in cognitive functions though these changes were not statistically significant. We also conclude that there is no gender disparity in the cognitive performance in the same age group.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Razvi_2013, title = {Clinical and histo pathological study of primary cutaneous macular amyloidosis}, author = {Fatima Razvi and A. S. Kumar}, url = {https://jmas.in/fulltext/154-1450011426.pdf?1676002667}, issn = {2231-1696}, year = {2013}, date = {2013-02-28}, urldate = {2013-02-28}, journal = {Journal of Medical and Allied Sciences}, volume = {3}, issue = {1}, pages = {22-25}, abstract = {Primary cutaneous amyloidosis often presents with pigmentary dystonias of the skin in the form of asymptomatic reticulate hyperpigmentation or pruritic lichenoid papular lesions. The aim of this study was to evaluate the incidence of primary cutaneous macular amyloidosis and also to find out the possible etiological agents, to correlate their clinical disease with histopathological positivity for amyloid deposition, and to find out the percentage of positive cases by special stains. A total of 24 patients attending dermatology out-patient clinic of Princess Esra Hospital, Hyderabad over a period of 1 year presenting with hyperpigmented skin lesions and clinically diagnosed as macular amyloidosis were taken up for this study. }, keywords = {Dermatology}, pubstate = {published}, tppubtype = {article} } @article{David_2013, title = {Study to evaluate prevalence of depression, sleep wake pattern and their relation with use of social networking sites among first year medical students}, author = {M. Anthony David Swaroop Kumar and Syed Salman Hamid Hashmi}, url = {http://www.ijpmbs.com/index.php?m=content&c=index&a=show&catid=115&id=39}, issn = {2278-5221}, year = {2013}, date = {2013-01-31}, journal = {International Journal of Pharma Medicine and Biological Sciences}, volume = {2}, issue = {1}, pages = {27-31}, abstract = {The stress of getting into medicine can contribute to the development of depression in medical students. The use of social networking sites might help students to decrease their stress levels, increase their social interaction which in turn may curb depression. A cross-sectional anonymous questionnaire-based survey was conducted amongst the first year medical students. The depression status. sleep wakefulness patterns and usage pattern of social networking sites were included in the survey. Data analysis was done and significance and correlation determined with the chi -square test. A total of 128 students participated of whom 11.7% students reported clinical depression. Depression was higher among the females compared to males. Depression was slightly higher, though not significantly so, among users of social networking websites. Overall more than half of the population were intermediate type personalities followed by evening types and morning types. As there were more evening types in users that the non-users there might be some effect of the use of social networking sites on sleep wake pattern but no statistically significant relation could be established}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2013, title = {Estimation of lecithin cholesterol acyl transferase activity and high density lipoprotein cholesterol in type 2 diabetes mellitus}, author = {Tahmeen Jameel and Syed Mahmood Ahmed }, url = {https://www.cibtech.org/J-MEDICAL-SCIENCES/PUBLICATIONS/2013/Vol_3_No_3/JMS-14-022-TAHMEEN-%20ESTIMATION-%20MELLITUS.pdf}, issn = {2277-2103}, year = {2013}, date = {2013-01-01}, urldate = {2013-01-01}, journal = {International Journal of Basic and Applied Medical Sciences}, volume = {3}, issue = {3}, pages = {100-109}, abstract = {An important enzyme in modulating plasma HDL levels is lecithin cholesterol acyl transferase (LCAT) which is responsible for the formation of most of the cholesterol esters (CE) present in human plasma. This enzyme catalyses the transfer of fatty acid from the Sn-2 position of the lecithin to the free hydroxyl group of cholesterol. It utilizes linoleate for the esterification of cholesterol in preference to the other fatty acids. Thus the enrichment of the linoleate content of plasma lecithin which accompanies ingestion of a poly unsaturated fat diet leads to an increase in the proportion of cholesterol linoleate in plasma. The physiological substrate for LCAT is probably nascent HDL. The enzyme activity is dependent on apoA-1 and is inhibited by apoA-2. Thus the maturing HDL particles contain mainly esterified cholesterol which having been rendered non diffusible are trapped in the HDL and then are transferred to the liver to undergo catabolism. Present studies have been carried out on diabetic patients with good glycaemic control and diabetics with poor glycaemic control and compared with normal control group. HDL cholesterol levels in diabetic patients with good and poor glycaemic control were significantly lower than the normal control group. LCAT in diabetic patients with good and poor glycaemic control were significantly lower than the normal control group. However HDL cholesterol level and LCAT activity in diabetic patients with poor glycaemic control was still lower this supports the observation that coronary artery disease (CAD) is 2-4 times higher in diabetes than in non diabetes.}, keywords = {Biochemistry, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Jameel_2013b, title = {Estimation of lipid profile in type 2 diabetes mellitus}, author = {Tahmeen Jameel and Raisa Faheem and Syed Mahmood Ahmed}, url = {https://www.cibtech.org/J-MEDICAL-SCIENCES/PUBLICATIONS/2013/Vol_3_No_3/JMS-05-006-%20TAHMEEN-%20ESTIMATION-%20MELLITUS.pdf}, issn = {2277-2103}, year = {2013}, date = {2013-01-01}, urldate = {2013-01-01}, journal = {International Journal of Basic and Applied Medical Sciences}, volume = {3}, issue = {3}, pages = {24-38}, abstract = {Impaired Lipid Metabolism resulting from uncontrolled hyperglycemia has been implicated in cardiovascular complications in diabetes patients. In the present study the impact of glycaemic control on the lipid profile of diabetic patients is examined. Lipoprotein levels are measured in non-diabetic persons and NIDDM (Type 2 DM) patients with good control and poor control of Diabetes mellitus (DM). The present study also reveals that reducing LDL cholesterol is beneficial in reducing CAD risk and lowering of LDL cholesterol being a primary target in the prevention of CAD.}, keywords = {Biochemistry, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{Faheem_2013, title = {Study of serum adenosine deaminase activity (ADA) in diabetes mellitus with complications}, author = {Raisa Faheem and Tahmeen Jameel }, url = {https://www.cibtech.org/J-LIFE-SCIENCES/PUBLICATIONS/2013/Vol_3_No_3/JLS-20-18...AFROZE...%20STUDY...%20COMPLICATIONS.pdf}, issn = {2231– 6345}, year = {2013}, date = {2013-01-01}, urldate = {2013-01-01}, journal = {Indian Journal of Fundamental and Applied Life Sciences}, volume = {3}, issue = {3}, pages = {142-149}, abstract = {Diabetes mellitus is a complex syndrome characterized by hyperglycemia, leading to vascular complications such as retinopathy, neuropathy and macrovascular disease like atherosclerosis. Patients with diabetes with complications and without complications are taken up for the study. The parameter serum Adenosine Deaminase, Activity (ADA) is considered, which is helpful in understanding the predisposing factors and the assessment of these patients to develop complications. The present study reveals that serum ADA is found to be raised in diabetic patients without complications while it is similar to control group with complications. This indicates that increased susceptibility of diabetes to develop a variety of bacterial and fungal infection may not be due to immune deficiency.}, keywords = {Biochemistry}, pubstate = {published}, tppubtype = {article} } @book{Mathur_2013, title = {Principles of Pharmacology for B.Sc. Nursing}, author = {Shobhana Mathur}, isbn = { 9788189966140}, year = {2013}, date = {2013-01-01}, booktitle = {Principles of Pharmacology for B.Sc. Nursing}, publisher = {Frontline Publications}, edition = {2nd}, keywords = {Pharmacology}, pubstate = {published}, tppubtype = {book} } @book{Hasan_2013, title = {Handbook of Blood Gas/Acid-Base Interpretation}, author = {Ashfaq Hasan}, url = {https://link.springer.com/book/10.1007/978-1-4471-4315-4}, doi = {10.1007/978-1-4471-4315-4}, isbn = {9781447143154}, year = {2013}, date = {2013-01-01}, urldate = {2013-01-01}, booktitle = {Handbook of Blood Gas/Acid-Base Interpretation}, publisher = {Springer London}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @book{Hasan_2013b, title = {Zrozumiec wentylacje mechaniczna}, author = {Ashfaq Hasan}, editor = {Dariusz Meciejewski [Translation from English to Polish]}, isbn = {9788361104773}, year = {2013}, date = {2013-01-01}, booktitle = {Zrozumiec wentylacje mechaniczna}, publisher = {Medipage}, address = {Warszawa}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @book{Mrudula_2013, title = {Handbook of Muscles}, author = {Chandrupatla Mrudula}, year = {2013}, date = {2013-01-01}, booktitle = {Handbook of Muscles}, publisher = {Osmania Medical Publishers}, address = {Hyderabad}, edition = {3rd}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {book} } @article{Ahmad_2012, title = {Impact of life style modifications among diabetics in an urban slum of Mumbai}, author = {Sultan Rizwan Ahmad and Gajanan D Velhal and Yasmeen K Kazi}, url = {https://njcmindia.com/index.php/file/article/view/1784/1465}, issn = {0976-3325}, year = {2012}, date = {2012-12-31}, urldate = {2012-12-31}, journal = {National Journal of Community Medicine}, volume = {3}, issue = {4}, pages = {636-641}, abstract = {Purpose: Present study was undertaken to assess the impact of life style modifications and self care practices, among type II diabetics. Methodology: An experimental epidemiological study adopting before and after intervention study design, was undertaken in an urban slum in Mumbai. Representative sample of 200 type II diabetics, received package of interventions along with follow up for 12 months, to assess the impact. Findings: Present study reveals good family support to the patients (90%). Blood sugar, BP, BMI and calories intake decreased significantly after intervention, along with improvement in life style (29% to 40% of patients) and self care practices (1.5% to 15% of patients), with clear difference according to the level of modifications. Major life style modifications and self care practices include spacing of meals, regular exercises, self examination of urine, foot care and carrying biscuits/sugar during traveling. Conclusion: Life style modifications and self care practices promote health of type II diabetics evident by qualitative and quantitative parameters. }, keywords = {Community Medicine}, pubstate = {published}, tppubtype = {article} } @article{pmid23181228, title = {Serum calcium level in hypertension}, author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Syed Muzzakar and Vontela Devender Reddy}, doi = {10.4103/1947-2714.103316}, issn = {1947-2714}, year = {2012}, date = {2012-11-01}, urldate = {2012-11-01}, journal = {North American Journal of Medical Sciences}, volume = {4}, issue = {11}, pages = {569-572}, abstract = {BACKGROUND: The alterations in extracellular calcium level may influence intracellular calcium level and possibly play a role in the pathogenesis of essential hypertension. AIM: The purpose was to find out the association between serum calcium levels and hypertension; and to compare the serum calcium levels between normotensive controls, hypertensive subjects on calcium channel blockers, and hypertensive subjects on antihypertensive medication other than calcium channel blockers. MATERIALS AND METHODS: Thirty one individuals including normotensives (n = 12) and hypertensives (n = 19) were enrolled for the study and their blood pressure recorded. Hypertensive group was sub divided into two: hypertensives on calcium channel blockers and hypertensives on antihypertensive medication other than calcium channel blockers. Serum calcium levels were measured by Accucare Calcium Arsenazo III kit. Differences between the groups were analyzed using ANOVA. RESULTS: No significant difference in serum calcium level was found between normotensive and hypertensive groups; and no correlation was found between calcium levels and the blood pressure. Also the difference in serum calcium levels in hypertensive group on calcium channel blockers and those on antihypertensive other than calcium channel blockers was insignificant. CONCLUSIONS: Serum calcium levels are tightly regulated. Subtle changes in serum levels do not affect blood pressure.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Reddy_2012, title = {Lung function parameters, neck pain and associated factors among male rubber tapping workers in Kerala}, author = {Vontela Devender Reddy and Bhaskarpillai Santhosh Kumar and Nazia Uzma }, url = {http://www.ijpmbs.com/index.php?m=content&c=index&a=show&catid=114&id=8}, issn = {2278-5221}, year = {2012}, date = {2012-10-31}, urldate = {2012-10-31}, journal = {International Journal of Pharma Medicine and Biological Sciences}, volume = {1}, issue = {2}, pages = {43-48}, abstract = {Rubber tapping causes various health problems among rubber tapping workers. It varies from simple musculoskeletal aches to more serious and complicated structural damage to bone, muscles, tendons and nerves of musculoskeletal system. The present study was conducted in rubber tapping workers in two districts of Kerala. A total of 343 rubber tapping workers were included and 246 subjects with same socio economic status and equivalent physical activity workers were elected as control subject. The most common affected body region among respondents was neck pain (NP) (72.2%) followed by low back pain (66.2%), shoulders pain (44.9%), knee pain (55.8%), ankles/feet pain (34.4%), elbow pain (33.2%), upper back pain (30.8%), wrists pain (50.1%) and hip/thighs pain (15.3%). Boarder line significant difference was observed in the alteration of lung function in rubber tappers and controls. The study revealed that the workers were in potential risk of neck pain and various other musculo skeletal diseases (MSD) and lung function abnormalities due to exposure to acids, which are being used for the coagulation of latex.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Khan_2012, title = {A study of craniofacial anthropometrics in Hyderabad (Deccan)—and a review of literature}, author = {Nowsheen Khan and Vasanta Leela and Annavarapu Gopalakrishna}, url = {https://jmas.in/?mno=210563}, issn = {2231-1696}, year = {2012}, date = {2012-08-31}, journal = {Journal of Medical and Allied Sciences}, volume = {2}, issue = {2}, pages = {54-57}, abstract = {The development of an anthropometric craniofacial data base is a necessary multidisciplinary initiative, and on anthropometry of the South-Indian face is inadequate. The purpose of this investigation is to obtain average parameters that define the soft tissue facial profile of the investigated population in order to provide an important reference for community, security, social and medical applications. In this pilot study, the faces of 40 young adults were studied with standardized photography and measurements, and the data collated to determine averages for the Deccan region ethnic sub-set. This data-set has been compared and contrasted with others in literature.}, keywords = {Anatomy, Plastic Surgery}, pubstate = {published}, tppubtype = {article} } @article{Arifuddin_2012, title = {Blood pressure variations during different phases of menstrual cycle}, author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari and Barra Ram Reddy}, url = {http://www.scienceandnature.org/IJSN/IJSN_Vol3(3)S2012/IJSN-VOL3(3)12-14.pdf}, issn = {0973-3140}, year = {2012}, date = {2012-08-10}, journal = {International Journal of Science and Nature}, volume = {3}, issue = {3}, pages = {551-554}, publisher = {Society For Science and Nature}, abstract = {Blood pressure (BP) is not constant throughout the day, on different days in a month and on different times of a cyclical event like menstrual cycle. Variation in BP during different phases of menstrual cycle can also be attributed to the effect of female sex hormones on cardiovascular function. The purpose of this study was to evaluate the variation in BP during different phases of menstrual cycle and whether these changes can warrant an increase or decrease in the dose of antihypertensive drugs in hypertensive women of reproductive age group. This study was conducted on a healthy female subject with regular menstrual cycle of 28 days duration using ambulatory BP monitor (TM-2430, A&D Co., Japan). 24-hour BP was recorded on alternate days for a period of 2 consecutive menstrual cycles. BP data was divided into four groups: menstrual phase (days 2 and 4), proliferative phase (days 6, 8, 10 and 12), ovulatory phase (day 14) and secretory phase (days 16, 18, 20, 22, 24, 26 and 28). Though the differences were noted between different phases of menstrual cycle, they were not statistically significant. To conclude, cardiovascular homeostatic mechanisms are strong enough to correct the subtle BP changes brought about by the action of ovarian hormones on the cardiovascular system.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Rao_2012, title = {The ABO blood group distribution and pulmonary tuberculosis}, author = {B. Narasimha Rao and Vontela Devender Reddy and P. S. Sahu and A. Veerendra Kumar and M. Anthony David Swaroop Kumar and P. Yugandhar and J. Muralishwar Rao}, url = {https://www.jcdr.net/article_abstract.asp?issn=0973-709x&year=2012&volume=6&issue=6&page=943&issn=0973-709x&id=2298}, doi = {10.7860/jcdr.2012.4370.2298}, issn = {0973-709X}, year = {2012}, date = {2012-08-01}, urldate = {2012-08-01}, journal = {Journal of Clinical and Diagnostic Research}, volume = {6}, issue = {6}, pages = {943-946}, publisher = {JCDR Research and Publications (P) Limited}, abstract = {Aim: Over the years, large number of studies have examined the possible relationship between the blood group type and infection. The present study was aimed at observing the pattern of the ABO blood group distribution among the pulmonary tuberculosis patients from the Andhra region of the Andhra Pradesh state, India. Methods: The ABO blood grouping and Rhesus typing were performed by using the standard slide agglutination reaction in 100 patients with a clinical and a radiological evidence of pulmonary tuberculosis and in 1400 healthy controls. Results: A significant association was observed between the incidence of tuberculosis and the blood groups B and AB (P values are 0.048 and 0.03 respectively). The association between the incidence of tuberculosis and the blood groups A and O (P values are 0.249 and 0.069 respectively) was found insignificant. However, a significant association between the incidence of tuberculosis and a positive Rhesus antigen was observed in the blood group A (P value is 0.009). But there was no significant association between the incidence of tuberculosis and a positive Rhesus antigen with the blood groups B, AB and O. Conclusion: The present study showed that there was an association between tuberculosis and the blood groups B and AB in this region of the Andhra Pradesh state.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @inbook{Tripura_2012, title = {Cell based therapy for chronic liver disease: Role of fetal liver cells in restoration of the liver cell functions}, author = {Chaturvedula Tripura and Aleem Ahmed Khan and Gopal Pande}, editor = {Pedro M. Baptista}, url = {https://www.intechopen.com/chapters/36999}, doi = {10.5772/45876}, isbn = {9789535106227}, year = {2012}, date = {2012-05-16}, urldate = {2012-05-01}, booktitle = {Liver Regeneration}, publisher = {InTechOpen}, chapter = {12}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {inbook} } @article{pmid22465897, title = {Cardiovascular autonomic dysfunction in type 2 diabetes mellitus and essential hypertension in a South Indian population}, author = {Mohammed Abdul Hannan Hazari and Reddipalli Tajuddin Khan and Barra Ram Reddy and Mohammed Abrar Hassan}, url = {https://nsj.org.sa/content/17/2/173}, issn = {1319-6138}, year = {2012}, date = {2012-04-01}, urldate = {2012-04-01}, journal = {Neurosciences (Riyadh)}, volume = {17}, issue = {2}, pages = {173-175}, publisher = {Saudi Medical Journal}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2012, title = {Correlation of clinical profiles with obstructive sleep apnea and metabolic syndrome}, author = {Ashfaq Hasan and Nazia Uzma and L. N. Swamy Tirunagari and Alluri Shoba and Bhaskarpillai Santhosh Kumar}, url = {https://link.springer.com/article/10.1007/s11325-010-0463-z}, doi = {10.1007/s11325-010-0463-z}, issn = {1520-9512}, year = {2012}, date = {2012-03-01}, urldate = {2012-03-01}, journal = {Sleep and Breathing}, volume = {16}, issue = {1}, pages = {111-116}, publisher = {Springer Science and Business Media LLC}, abstract = {Background: Obstructive sleep apnea (OSA) is a common condition being increasingly recognized and is associated with many diseases. Few data are available for Indian patients and public health hazard of the condition continues to be seriously underestimated in this country. The objective of this study was to evaluate the prevalence of obesity, hypertension, diabetes mellitus, and hyperlipidemia (HLP) in a South Indian population with proven OSA. Methods: A retrospective analysis of data accrued in patients undergoing polysomnography (PSG) was undertaken. Two hundred thirty-four patients of either sex in the age of 54 ± 11 years who tested positive for OSA were compared with control group. An apnea-hypopnea index (AHI) of >5 in the presence of snoring and daytime somnolence was taken to define sleep apnea. Results: The mean AHI among the study group with OSA was 31.3 ± 18.6 as compared with 1.2 ± 0.5 in the control group. The BMI among patients with OSA was 36 ± 6 as compared with 29 ± 4 in comparison group (p < 0.001). Among the patients with OSA, 31% were having HLP, 59% were diabetics, and 86% were hypertensive. Subjects with PSG-proven OSA had significant levels of day time sleepiness, lack of concentration, changes in mood, morning headache, and dry mouth. Nonrestorative sleep, awakening with choking, nocturnal dyspnea, insomnia with frequent awakenings, nocturia, and diaphoresis were observed in (>80%) patients. A significant difference in the sleep efficiency (16%), sleep onset (14%), and mean saturation (9%) was observed in the study group as compared to the control group. Conclusions: The risk of obesity, hypertension, diabetes mellitus, and HLP in OSA syndrome patients was almost three times more than that of the comparing group.}, keywords = {Physiology, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @book{Mrudula_2012, title = {Concise Anatomy}, author = {Chandrupatla Mrudula and M. Krishnaiah}, year = {2012}, date = {2012-01-01}, booktitle = {Concise Anatomy}, publisher = {Osmania Medical Publishers}, address = {Hyderabad}, edition = {1st (Reprint)}, keywords = {Anatomy}, pubstate = {published}, tppubtype = {book} } @article{Nasreen_2012, title = {Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of leptazol induced convulsions}, author = {Zahida Nasreen and Tahmeen Jameel and Ashfaq Hasan and Parveen Naimath and B. Sadasivudu}, url = {https://link.springer.com/article/10.1007/s11064-011-0603-2}, doi = {10.1007/s11064-011-0603-2}, issn = {0364-3190}, year = {2011}, date = {2011-09-21}, urldate = {2011-09-21}, journal = {Neurochemical Research}, volume = {37}, issue = {1}, pages = {202-204}, abstract = {The activities of Glutamate decarboxylase (GAD) and Gamma aminobutyric acid (GABA) were studied in three regions of rat brain in heightened neuronal activity resulting in convulsions by Leptazol. These enzymes were studied in preconvulsive, convulsive and post convulsive phases. The activity of GAD decreases significantly in the preconvulsive phase in all the three regions of brain followed by a significant increase during the convulsive and post convulsive phase in cerebral cortex and cerebellum. The activity of GABA-T decreases maximal during the preconvulsive phase followed by convulsive phase. The activity of this enzyme tended to increase to control values when the postconvulsive phase was reached. Therefore, it is suggested that the concomitant decrease of GAD activity and GABA concentration, is probably an important factor in the onset of convulsions.}, keywords = {Biochemistry, Central Research Laboratory, Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{pmid20737246, title = {Hepatoprotective, immunomodulatory, and anti-inflammatory activities of selenocystine in experimental liver injury of rats}, author = {Nazia Uzma and Bhaskarpillai Santhosh Kumar and K. Indira Priyadarsini}, url = {https://link.springer.com/article/10.1007/s12011-010-8807-x}, doi = {10.1007/s12011-010-8807-x}, issn = {0163-4984}, year = {2011}, date = {2011-09-01}, urldate = {2011-09-01}, journal = {Biological Trace Element Research}, volume = {142}, issue = {3}, pages = {723-734}, publisher = {Springer Science and Business Media LLC}, abstract = {The study was evaluated to investigate the efficacy of selenocystine (CysSeSeCys), a well-known organoselenium compound, on the prevention of carbon tetrachloride (CCl(4))-induced acute hepatic injury in Wistar rats. Forty healthy male Wistar rats were utilized in this study. Acute hepatotoxicity was induced by CCl(4) intoxication in rats. Serum biological analysis, oxidative stress, immune parameters, and gene expression of COX-2 and CYP2E1 were carried out. Pretreatment of CysSeSeCys prior to CCl(4) administration significantly prevented an increase in serum hepatic enzymatic activities. In addition, pretreatment of CysSeSeCys significantly prevented the formation of ROS, MDA, depletion of glutathione, and alteration of antioxidant enzyme activities in the liver of CCl(4)-intoxicated rats. This study also revealed that pretreatment with CysSeSeCys normalized the levels of interleukin 6 and10, IgG, and CD4 cell count. Pretreatment of CysSeSeCys significantly reversed COX-2 inflammatory response and the upregulation of CYP2E1 expression as well. Histopathological changes induced by CCl(4) were also significantly attenuated by CysSeSeCys pretreatment. CysSeSeCys has a potent hepatoprotective effect on CCl(4)-induced liver injury in rats through its antioxidative, immunomodulatory and anti-inflammatory activity. }, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2011, title = {Red wine ameliorates CCl4 - induced acute liver injury in rats}, author = {Nazia Uzma and Bhaskarpillai Santhosh Kumar and Syyeda Anees}, url = {http://www.sciencej.com/ajhb/kumar_1_1_2011_1_7.pdf}, issn = {1838-2258}, year = {2011}, date = {2011-06-23}, urldate = {2011-06-23}, journal = {Australian Journal of Biomedical Science}, volume = {1}, issue = {1}, pages = {1-7}, keywords = {Biochemistry, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Hasan_2011, title = {Amyotrophic lateral sclerosis presenting with orthopnea in a patient with COPD and obstructive sleep apnea}, author = {Ashfaq Hasan and Amrit B. Saxena and Syed Mahmood Ahmed and T. L. N. Swamy}, url = {https://jmas.in/fulltext/154-1449470473.pdf?1698477675}, issn = {2231-1696}, year = {2011}, date = {2011-01-31}, urldate = {2011-01-31}, journal = {Journal of Medical and Allied Sciences}, volume = {1}, issue = {1}, pages = {46-49}, abstract = {Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) is a relentlessly progressive neurological disorder causing peripheral muscular weakness and resultant respiratory failure. In this article, we report a case of ALS with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) with orthopnea as initial symptoms.}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {article} } @article{pmid20886531, title = {Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers}, author = {Nazia Uzma and Bhaskarpillai Santhosh Kumar and Mohammed Abdul Hannan Hazari}, doi = {10.1002/ajim.20901}, issn = {1097-0274}, year = {2010}, date = {2010-12-01}, urldate = {2010-12-01}, journal = {American Journal of Industrial Medicine}, volume = {53}, issue = {12}, pages = {1264-1270}, publisher = {John Wiley & Sons}, abstract = {BACKGROUND: Chronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India. METHODS: Four hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR). RESULTS: A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls. CONCLUSION: Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @inbook{Parveen_2010, title = {Gastrointestinal stem cells}, author = {Parveen Naimath and Aleem Ahmed Khan and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah}, editor = {Krishnarao Appasani and Raghu K. Appasani}, url = {https://link.springer.com/chapter/10.1007/978-1-60761-860-7_13}, doi = {10.1007/978-1-60761-860-7_13}, isbn = {9781607618591}, year = {2010}, date = {2010-11-01}, urldate = {2010-10-01}, booktitle = {Stem Cell Biology and Regenerative Medicine}, pages = {219-225}, publisher = {Humana Press}, chapter = {13}, abstract = {Stem cell research is advancing at an incredible pace, with new ­discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can ­replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.}, keywords = {Central Research Laboratory}, pubstate = {published}, tppubtype = {inbook} } @article{Kumar_2010b, title = {Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model}, author = {Bhaskarpillai Santhosh Kumar and Santosh K. Tiwari and R. Saikant and G. Manoj and Amit Kunwar and G. Sivaram and Zakia Abid and Adeel Ahmad and K. Indira Priyadarsini and Aleem Ahmed Khan}, url = {https://doi.org/10.1016%2Fj.jtemb.2010.04.003}, doi = {10.1016/j.jtemb.2010.04.003}, year = {2010}, date = {2010-10-01}, urldate = {2010-10-01}, journal = {Journal of Trace Elements in Medicine and Biology}, volume = {24}, issue = {4}, pages = {263-270}, publisher = {Elsevier BV}, keywords = {Central Research Laboratory, Pathology, Physiology}, pubstate = {published}, tppubtype = {article} } @article{nokey, title = {Cardiovascular autonomic neuropathy in patients with diabetes mellitus}, author = {Nazeema Khatoon and Bhaskarpillai Santhosh Kumar and Mohammed Abdul Hannan Hazari}, url = {https://www.ijpbs.net/abstract.php?article=NTI0}, issn = {0975-6299}, year = {2010}, date = {2010-09-01}, urldate = {2010-09-01}, journal = {International Journal of Pharma and Biosciences}, volume = {1}, issue = {3}, abstract = {The cardioautonomic reflexes of 82 diabetic subjects and 40 age and sex matched healthy controls were studied using blood pressure and heart rate variation in response to standing, deep breathing, isometric exercise, cold pressor test and determination of QTc interval. Among the 82 patients, 68 patients were found to have cardiac autonomic neuropathy (CAN). Results showed that diabetics had significantly impaired cardioautonomic reflexes compared to non-diabetics, which increases with the duration of diabetes. Out of 68 patients with CAN, QTc prolongation was observed in 64 patients. In conclusion the autonomic nervous system integrity is appeared to be greatly affected by diabetes mellitus and the degree of impairment was dependent on duration of the disease.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Kumar_2010c, title = {Anti-hemolytic and peroxyl radical scavenging activity of organoselenium compounds: An in vitro study}, author = {Bhaskarpillai Santhosh Kumar and Amit Kunwar and Beena G. Singh and Adeel Ahmad and K. Indira Priyadarsini}, url = {https://doi.org/10.1007%2Fs12011-010-8692-3}, doi = {10.1007/s12011-010-8692-3}, year = {2010}, date = {2010-04-01}, urldate = {2010-04-01}, journal = {Biological Trace Element Research}, volume = {140}, issue = {2}, pages = {127-138}, publisher = {Springer Science and Business Media LLC}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Manoj_2010, title = {Genetic variability in the repeat region of cytotoxin associated gene A of Indian Helicobacter pylori strains and its implication on various acid peptic disorders}, author = {G. Manoj and Santosh K. Tiwari and G. Sivaram and R. Saikant and Avinash Bardia and Bhaskarpillai Santhosh Kumar and Zakia Abid and Md. Aejaz Habeeb and Aleem Ahmed Khan and Chitoor Mohammed Habibullah}, url = {http://www.sciencej.com/ri/RIF_aleem_1_1_2010_31_37.pdf}, issn = {1837-6738}, year = {2010}, date = {2010-03-31}, urldate = {2010-03-31}, journal = {Reviews in Infection}, volume = {1}, issue = {1}, pages = {31-37}, keywords = {Central Research Laboratory, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Tiwari_2010, title = {Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels}, author = {Santosh K. Tiwari and G. Manoj and Vishwas Sharma and G. Sivaram and R. Saikant and Avinash Bardia and Varun K. Sharma and Zakia Abid and Aleem Ahmed Khan and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah and Bhaskarpillai Santhosh Kumar and Amrita Nandan}, url = {https://doi.org/10.1007%2Fs10787-010-0031-y}, doi = {10.1007/s10787-010-0031-y}, year = {2010}, date = {2010-02-01}, urldate = {2010-02-01}, journal = {Inflammopharmacology}, volume = {18}, issue = {2}, pages = {59-64}, publisher = {Springer Science and Business Media LLC}, keywords = {Central Research Laboratory, Pathology, Physiology}, pubstate = {published}, tppubtype = {article} } @article{Kumar_2010, title = {Anti-unlcer and antimicrobial activities of sodium selenite against Helicobacter pylori: In vitro and in vivo evaluation}, author = {Bhaskarpillai Santhosh Kumar and Santosh K. Tiwari and G. Manoj and Amit Kunwar and N. Amrita and G. Sivaram and Zakia Abid and Adeel Ahmad and Aleem Ahmed Khan and K. Indira Priyadarsini}, url = {https://doi.org/10.3109%2F00365540903493707}, doi = {10.3109/00365540903493707}, year = {2010}, date = {2010-01-01}, urldate = {2010-01-01}, journal = {Scandinavian Journal of Infectious Diseases}, volume = {42}, issue = {4}, pages = {266-274}, publisher = {Informa UK Limited}, keywords = {Central Research Laboratory, Physiology}, pubstate = {published}, tppubtype = {article} } @book{Hasan_2010, title = {Understanding mechanical ventilation}, author = {Ashfaq Hasan}, isbn = {978-1-84882-868-1}, year = {2010}, date = {2010-01-01}, urldate = {2010-01-01}, booktitle = {Understanding mechanical ventilation}, publisher = {Springer-Verlag}, address = {London, England}, edition = {2}, keywords = {Respiratory Medicine}, pubstate = {published}, tppubtype = {book} } @article{Kumar_2009, title = {In-vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides}, author = {Bhaskarpillai Santhosh Kumar and Amit Kunwar and Adeel Ahmad and L. B. Kumbhare and V. K. Jain and K. Indira Priyadarsini}, url = {https://link.springer.com/article/10.1007/s00411-009-0240-1}, doi = {10.1007/s00411-009-0240-1}, issn = {0301-634X}, year = {2009}, date = {2009-09-16}, urldate = {2009-09-01}, journal = {Radiation and Environmental Biophysics}, volume = {48}, issue = {4}, pages = {379-384}, publisher = {Springer Science and Business Media LLC}, abstract = {Organoselenium compounds belonging to the class of monoselenides, such as selenomethionine (SeM) and methylselenocysteine (MSeCys) and diselenides including selenocystine (SeCys) and selenopropionic acid (SePA), were examined for their comparative radioprotective effects using in vitro models. Effects of these compounds on the inhibition of γ-radiation induced lipid peroxidation in liposomes, protein carbonylation in bovine serum albumin (BSA) and strand breaks in pBR322 plasmid DNA, assessed, respectively, by the formation of thiobarbituric acid reactive substances, formation of 2,2′-dinitrophenyl hydrazine (DNPH) carbonyl complex and horizontal gel electrophoresis, were used to compare their radioprotective ability. The IC50 values for SeCys, SePA, SeM and MSeCys for lipid peroxidation were 27 ± 1, 33 ± 2, 200 ± 8 and 163 ± 4 μM, respectively, and the values for inhibition of protein carbonylation were >200, 300 ± 6, 464 ± 8 and 436 ± 3 μM, respectively. Inhibition of DNA strand break formation was tested at 200 μM for all the compounds and SePA and SeCys exhibited a protective effect on DNA, while SeM and MSeCys did not lead to any protection. The in vitro cytotoxicity studies in normal and tumor cells revealed that MSeCys and SeM were not cytotoxic to lymphocytes and EL4 tumor cells at the concentrations employed. In contrast, SeCys was toxic, with a higher effect on tumor cells than lymphocytes. Our studies suggest that the non-toxic diselenides like SePA should be explored as protective agents against γ-irradiation induced damage.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Uzma_2009, title = {A comparative clinical survey of the prevalence of refractive errors and eye diseases in urban and rural school children}, author = {Nazia Uzma and Bhaskarpillai Santhosh Kumar and B. M. Khaja Mohinuddin Salar and Mohammed Atheshm Zafar and Vontela Devender Reddy}, url = {https://www.canadianjournalofophthalmology.ca/article/S0008-4182(09)80093-8/pdf}, doi = {10.3129/i09-030}, issn = {0008-4182}, year = {2009}, date = {2009-06-30}, urldate = {2009-06-01}, journal = {Canadian Journal of Ophthalmology}, volume = {44}, issue = {3}, pages = {328-333}, publisher = {Elsevier BV}, abstract = {Objective: To assess the prevalence of refractive error and common ocular diseases in school-aged children in urban and rural populations in and around Hyderabad, India. Design: Population-based, cross-sectional study. Participants: A total of 3314 school children, 1789 from urban areas and 1525 from rural areas. Methods: The examination included visual acuity measurements, retinoscopy and autorefraction under cycloplegia, examination of the anterior segment and external eye, and ocular motility evaluation. Results: In the urban group the prevalence of uncorrected presenting and best-corrected visual impairment (≤20/40 in the better eye) was 9.8%, which dropped to 7.1% with presenting vision and was further reduced to 1.1% with best-corrected visual acuity. Uncorrected visual acuity in the rural group was 6.6%, which dropped to 3.3% with presenting vision and was further reduced to 2.5% with best-corrected visual acuity. The prevalence of refractive error was greater (25.2%) in the urban than the rural group (8%). Myopia measured with autorefraction was observed in 51.4% of urban children and 16.7% in rural children. Increased literacy rate, duration of study hours, and older age of the child were found to have contributed more to the prevalence of myopia in the urban group. Hyperopia with autorefraction was found to be 3.3% in the urban and 3.1% in the rural group. Hyperopia was associated with younger age in the study group. Trachoma was the leading cause of ocular morbidity in the rural group (3.5%) compared with the urban group (0.16%). Night blindness was reported in 3.2% of children in the rural group and 0.33% in the urban group. Vitamin A deficiency, low socio-economic status, and poor personal and environmental hygienic practice were found to have a positive correlation with ocular morbidity among rural group children. Conclusions: Provision of health education, periodic visual screening programs, and primary eye care by trained health care personnel in the elementary schools will prevent the prevalence of refractive errors and common ocular diseases in school children.}, keywords = {Physiology}, pubstate = {published}, tppubtype = {article} } @article{Tiwari_2008, title = {Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer}, author = {Santosh K. Tiwari and G. Manoj and G. Vasanth Kumar and G. Sivaram and Syed Ibrahim Hassan and B. Prabhakar and U. Devi and S. Jalaluddin and K. Kumar and S. Ahmed and Zakia Abid and Md. Aejaz Habeeb and Aleem Ahmed Khan and Chitoor Mohammed Habibullah}, url = {https://doi.org/10.1136%2Fpgmj.2007.065060}, doi = {10.1136/pgmj.2007.065060}, year = {2008}, date = {2008-04-01}, urldate = {2008-04-01}, journal = {Postgraduate Medical Journal}, volume = {84}, issue = {990}, pages = {193-197}, publisher = {Oxford University Press (OUP)}, keywords = {Central Research Laboratory, Medical Gastroenterology, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Tiwari_2007, title = {A simple multiplex PCR assay for diagnosing virulent Helicobacter pylori infection in human gastric biopsy specimens from subjects with gastric carcinoma and other gastro-duodenal diseases}, author = {Santosh K. Tiwari and Aleem Ahmed Khan and G. Manoj and S. Ahmed and Zakia Abid and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah}, url = {https://doi.org/10.1111%2Fj.1365-2672.2007.03478.x}, doi = {10.1111/j.1365-2672.2007.03478.x}, year = {2007}, date = {2007-09-01}, urldate = {2007-09-01}, journal = {Journal of Applied Microbiology}, volume = {103}, issue = {6}, pages = {2353-2360}, publisher = {Oxford University Press (OUP)}, keywords = {Central Research Laboratory, Pathology}, pubstate = {published}, tppubtype = {article} } @article{Koti_2023d, title = {A study on efficacy of unilateral spinal anesthesia with low dose hyperbaric bupivacaine}, author = {Vijaya Rekha Koti and Nooruddin Owaisi and Mohammed Asraruddin and Syed Asrar Hussain}, url = {https://www.lcebyhkzz.cn/article/view/2023/4960.pdf}, issn = {1001-1781}, journal = {Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery}, volume = {27}, issue = {1}, pages = {4960-4966}, abstract = {Background and Objectives: Unilateral spinal anaesthesia is a promising alternative to traditional, widely used techniques of central neuraxial blocks, as it restricts markedly the anaesthetized area thereby, decreases the risk of adverse events and complications. The present study was taken up to assess the hemodynamic effects of low dose 1.5 ml (7.5 mg) of 0.5% hyperbaric Bupivacaine and also to assess the level achieved and duration of block. Methods: The present one year clinical trial was conducted in the Department of Anesthesiology, during the period of one year at Deccan College of Medical Sciences, affiliated to Owaisi Hospital and Princess Esra Hospital, Hyperabadon 100 ASA II and III patients undergoing unilateral lower limb surgery under unilateral spinal anaesthesia with bupivacaine. 1.5 ml of (7.5 mg) 0.5% bupivacaine heavy was injected with patient in lateral position with the limb to be operated on the lower side. Results: In this study out of 100 patients studied 72 (72%) were males with male to female ratio of 2.57:1. Majority of the patients (45%) were aged between 46 to 60 years. Overall mean age was 47.79 years and mean weight was 57.90 Kgs. The SBP, DBP and MBP showed a gradual fall with maximum fall noted at 40 minutes and gradually increased, subsequently reaching the baseline levels at 90 minutes. The maximum increase in HR was seen at 40 minutes after giving spinal and it gradually reduced coming to baseline levels at 90 minutes. Maximum sensory level of L1 was achieved. The block remained unilateral in 74.8% of the cases. Motor blockade was adequate in the limb to be operated. Conclusion: Subarachnoid block with 1.5 mL (7.5 mg) of 0.5% hyperbaric bupivacaine used in this study does not produce any adverse hemodynamic changes and lasts for short duration that is 90 minutes and can be used in surgeries of shorter duration.}, keywords = {Anesthesiology}, pubstate = {published}, tppubtype = {article} }