@article{Mohammedi_2018,

title = {Effect of nicotine on platelet function},

author = {Fariha Mohammedi and Mohammed Abdul Hannan Hazari and Farisa Khatoon and Kazi Husna Abdul Naeem and Syed Imran Ali},

url = {https://www.medpulse.in/Physiology/html_5_2_2.php},

doi = {10.26611/103522},

issn = {2550-7613},

year  = {2018},

date = {2018-02-10},

urldate = {2017-02-28},

journal = {MedPulse International Journal of Physiology},

volume = {5},

issue = {2},

pages = {13-16},

publisher = {MedPulse Publishing Corporation},

abstract = {Background: Tobacco is the dried and processed leaves of the plant Nicotiana tobacum that is widely cultivated and commercially grown in many countries of the world. In India, tobacco is taken in several other forms also, for example, Pan (betel quid), dried leaves (Patti), paste (Qiwam, Zarda), tobacco with lime (Khaini/Mawa). Its use is common in various parts of the world, including India and central Asia. An increase in the consumption of tobacco has been noticed among high school students, college students, and sports persons .This is immensely popular in all socio-economic states in India. It is viewed as especially ominous because of the ease , low expense of procurement, youth appeal, convenient shelf life and lack of social stigma. Despite the known health consequences of tobacco chewing‖ is not viewed by users as particularly dangerous and is considered less of a ―social evil‖ than smoking by much of the public. Previous reports have described long-term harmful effects of nicotine on various body parameters.. In view of the various pharmacological actions of nicotine and additives and the wide use in many regions and countries, chronic consumption  may affect the status of hematological parameters and further delineate the effects of tobacco use to health. The effect of smokeless tobacco use on health irrespective of the mode of consumption has been well documented. Objective: this study was conducted to determine hematological effects of nicotine on platelet count and its functions. Materials and Methods: This cross sectional study was done in the department of internal medicine Owaisi Hospital and Research Centre. A detailed assessment was done on 200 apparently healthy subjects, out of which 100 were tobacco chewers and 100 non chewers. Various parameters were recorded which include personal details, department of work, history of smoking , chewing tobacco, history of exposure to tobacco smoke, history of any chronic disease like diabetes mellitus and medication history. Hematological investigations done. Automated blood analyzer was used for estimation of platelet count Results: In tobacco chewers the following platelet parameters are higher than non-chewers. 1. Platelet count -Statistically significant. 2. PCT- not significant statistically.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Yasmeen_2018,

title = {Immediate effects of mobile phone radiations on heart rate variability in college going students},

author = {Juveriya Yasmeen and Mehnaaz Sameera Arifuddin and Nazeema Khatoon and Umaima Mahveen and Mohammed Abdul Hannan Hazari},

url = {https://njppp.com/?mno=273250},

doi = {10.5455/njppp.2018.8.0727708082017},

issn = {2320-4672},

year  = {2018},

date = {2018-01-31},

urldate = {2017-01-31},

journal = {National Journal of Physiology, Pharmacy and Pharmacology},

volume = {8},

issue = {1},

pages = {56-61},

publisher = {ScopeMed},

abstract = {Background: The use of mobile phone has increased excessively these days which can have a deleterious effect on human tissues and organs, especially cardiovascular system (CVS). The effects on CVS can be detected at an early stage by analyzing alterations in heart rate variability (HRV).

Aims and Objectives: This study was designed to determine the effect of mobile phone use with different components of HRV.

Materials and Methods: In our study, HRV was measured in 95 college-going students (males: 49 and females: 46) using root mean square polyrite-D during 3 phases with each phase being recorded continuously for 2 min: Phase 1: Basal recording; Phase 2: Mobile phone use during active call with direct contact to the ear; and Phase 3: Mobile phone use during active call with earphones. Data obtained were subjected to statistical analysis using repeated measures non-parametric test followed by multiple comparison tests.

Results: There was a significant increase in mean HR and decrease in mean RR interval from baseline through Phase 3 to Phase 2. This study shows that there was statistically significant change in root of the mean of the sum of the squares of differences, low frequency (LF), high frequency (HF), and LF/HF ratio between basal recording and during active call (direct contact of mobile phone to the ear and also with use of earphones); however, no change was seen between direct contact of mobile phone to the ear and during the use of earphones. Standard deviation of all normal-to-normal intervals did not show any significant change. We also observed gender differences in some of the HRV parameters.

Conclusion: There is a considerable effect of mobile phone use on HR and HRV parameters. Furthermore, the changes noted are less with earphone use than when compared with the use of mobile phone in direct contact with the ear though these differences were not significant statistically.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Farheen_2017,

title = {Hematological parameters are acutely effected by cement dust exposure in construction workers},

author = {Ayesha Farheen and Mohammed Abdul Hannan Hazari and Farisa Khatoon and Fareen Sultana and Sanam Maria Qudsiya},

url = {https://amphysiol.com/index.php/amp/article/view/v1i1.263312},

doi = {10.23921/amp.2017v1i1.263312},

issn = {2456-8422},

year  = {2017},

date = {2017-04-13},

urldate = {2017-04-13},

journal = {Annals of Medical Physiology},

volume = {1},

issue = {1},

pages = {31-35},

abstract = {Cement dust poses an occupational hazard causing respiratory (owing to its inhalation), dermatological, ocular and hematological problems. The purpose of the current study was to evaluate the effect of occupational exposure of cement dust on hematological parameters in construction workers. Apparently healthy sixty five (65) adult male construction workers aged 25-50 years participated in this study. Three (3.0) ml venous blood samples were collected from each participant for hematological analysis at two different time points, one at 8 AM and second at 4 PM at the end of work shift. Differences in means and test of significance were calculated using paired Student’s t-test. The results revealed that post shift samples showed statistically significant increase (p<0.05) in mean total leukocyte count (TLC), lymphocyte %, monocyte % and eosinophil %  and statistically significant decrease (p<0.05) in mean hemoglobin, red blood cell (RBC) count, packed cell volume (PCV) and platelet count. The present study confirms that hematological parameters are significantly effected in construction workers which may be attributed to the work atmosphere predominated with cement dust.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Qudsiya_2017,

title = {Study of intraocular pressure among individuals working on computer screens for long hours},

author = {Sanam Maria Qudsiya and Farisa Khatoon and Aftab Abdul Khader and Mohammed Asghar Ali and Mohammed Abdul Hannan Hazari and Fareen Sultana and Ayesha Farheen},

url = {https://amphysiol.com/index.php/amp/article/view/v1i1.263328},

doi = {10.23921/amp.2017v1i1.263328},

issn = {2456-8422},

year  = {2017},

date = {2017-04-11},

urldate = {2017-04-11},

journal = {Annals of Medical Physiology},

volume = {1},

issue = {1},

pages = {22-25},

publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House},

abstract = {In today’s world computers are ubiquitous and found in different forms which can effect intraocular pressure (IOP). Present study was undertaken to find out effect of day-to-day exposure to computer screen on IOP in normal individuals. 70 individuals (who met the screening conditions and devoid of obvious ocular pathology and systemic diseases) had their IOP’s checked before and 4 hour after computer session on same day, all working in general day shift, involving reading English printed material. The results showed significant (p<0.005) increase with IOP values before exposure being 17.89±3.25 and 16.99±2.84 and after exposure being 19.67±3.4 and 18.70±2.4 in left and right eye respectively. Increase in IOP was noted in 70% and 67% individuals in left and right eye. Differences in IOP of right and left eye may be due to dominance of eye or direction of script from left to right.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2017,

title = {Effect of stress on erythryocytic osmotic fragility in healthy individuals},

author = {Fareen Sultana and Farisa Khatoon and Mohammed Abdul Hannan Hazari and Sanam Maria Qudsiya and Ayesha Farheen},

url = {https://www.ijcap.org/article-details/3634},

doi = {10.18231/2394-2126.2017.0008},

issn = {2394-2118},

year  = {2017},

date = {2017-03-31},

journal = {Indian Journal of Clinical Anatomy and Physiology},

volume = {4},

issue = {1},

pages = {30-33},

publisher = {IP Innovative Publication Pvt. Ltd.},

abstract = {Background: The aim of the study was to examine relationship between severity of stress and onset/completion of erythrocyte haemolysis in normal healthy individuals.

Materials and Methods: The study was conducted in Physiology department, Deccan College of Medical Sciences, Hyderabad, after approval from the Institutional Review Board. The study included 50 healthy individuals of both the sexes aged between 20 to 50 years. Individuals working for minimum 8 to 10 hours a day were included and individuals suffering from hypertension, obesity, diabetes mellitus, musculo-skeletal disorders, sickle cell disease and goitre were excluded. Osmotic fragility was determined by collecting 2ml of blood from each individual and stored in EDTA tubes. A drop of blood was added to saline solutions of different tonicity arranged in 12 test tubes. The test tubes were seen for onset and end of hemolysis after an hour.

Stress was measured by Cohen’s perceived stress questionnaire and individual were divided into 3 groups viz. low, moderate and high stress categories as per their scores.

Results: Findings were analysed by student’s t-test and completion of hemolysis was earlier in severe stress group compared to mild and moderate. There is no significant difference between males and females regarding point of onset of hemolysis (p=0.41) and end of hemolysis (p=0.37). Stress increases fragility and it was found that RBC fragility was significantly related to severity of stress. Fragility is not affected by gender.

Conclusion: RBC fragility was significantly related to severity of stress and it was found that fragility is not affected by gender.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2017,

title = {Central blood pressure parameters in young adults with and without parental history of hypertension},

author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Hamza Zoeb Hussain and Farah Fatima and Nudrath Kahkashan},

url = {https://amphysiol.com/index.php/amp/article/view/v1i1.262334},

doi = {10.23921/amp.2017v1i1.262334},

issn = {2456-8422},

year  = {2017},

date = {2017-03-31},

urldate = {2017-03-31},

journal = {Annals of Medical Physiology},

volume = {1},

issue = {1},

pages = {16-21},

abstract = {Hypertension is increasingly being found in children and adolescence. The purpose of this study was to find out differences in the central arterial (aortic) blood pressure parameters in young adults with hypertensive and normotensive parents. 109 healthy volunteers between the ages of 17 and 25 years were enrolled for the study after taking consent. Brachial artery pressures and aortic parameters were recorded using PeriScope™ which determines aortic parameters and functional vascular age non-invasively based on oscillometric method. The results of this study showed no statistically significant difference between offspring of hypertensive parents and offspring of normotensive parents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hasan_2017,

title = {Is obstructive sleep apnea more prevalent than central sleep apnea in patients with systolic heart failure? A retrospective study},

author = {Ashfaq Hasan and Nazia Uzma and Fahad Abdullah Bin Breik and Mohammed Abdul Hannan Hazari and C. Narasimhan and L. Rao},

url = {https://www.hilarispublisher.com/archive/jcrdc-volume-3-issue-1-year-2017.html},

doi = {10.4172/2472-1247.1000126},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {Journal of Clinical Respiratory Diseases and Care},

volume = {03},

issue = {01},

pages = {126},

publisher = {OMICS Publishing Group},

abstract = {Central sleep apnea (CSA) rather than obstructive sleep apnea (OSA) is widely believed to be the dominant form of sleep apnea (SA) in patients with heart failure (HF). Hitherto, no study has characterized sleep disordered breathing (SDB) in Indian subjects with heart failure and evaluated its impact on severity of HF, which this study attempts to do. A retrospective data-analysis was done in 65 consecutive patients with stable mild-to-moderate HF referred for evaluation on the basis of fatigue and excessive daytime somnolence (EDS) regarded by the institute’s cardiologists. Patients with ejection fraction (EF) <55% or LV fractional shortening of 28% were included in the study. PSG was scored according to current AASM recommendations. Based on the Apnea-Hypopnea Index (AHI), OSA was classified as mild (AHI:5-15), moderate (AHI: 15-30) and severe (AHI: >30). HF was arbitrarily classified as mild (EF:<35%) moderate (EF:35-45%) and severe (EF:45-55%). OSA emerged as the exclusive form of SA (95.4%; n=65) and was more severe in males. Patients with more severe HF tended to be less obese, and interestingly to have less severe OSA. In contrast to Western literature, OSA seems to be by far the most prevalent form of sleep apnea in Indian subjects with HF. HF mortality is known to be high in underweight individuals yet, persons with severe HF are often less obese and partly by reason of a lower BMI, appear to be relatively protected against severe OSA and severe nocturnal hypoxemia. This study thus raises important and intriguing questions which merit further enquiry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2016c,

title = {Think out of the box},

author = {Mohammed Abdul Hannan Hazari},

url = {https://amphysiol.com/index.php/amp/article/view/v1i1.254258},

doi = {10.23921/amp.2017v1i1.254258},

issn = {2456-8422},

year  = {2016},

date = {2016-12-31},

urldate = {2016-12-31},

journal = {Annals of Medical Physiology},

volume = {1},

issue = {1},

pages = {1-2},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2016,

title = {Does anthropometric measurements correlate with hematological parameters after the adolescent growth period?},

author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari},

url = {https://ppj.phypha.ir/article-1-1166-en.html},

issn = {2476-5236},

year  = {2016},

date = {2016-09-30},

urldate = {2016-09-30},

journal = {Physiology and Pharmacology},

volume = {20},

issue = {3},

pages = {137-146},

publisher = {Iranian Society of Physiology and Pharmacology},

abstract = {Introduction: Musculoskeletal growth is variable during adolescent period and reaches its maximum by 18 years, whereas hemopoietic parameters reach adult values by 15 years. After adolescence period, the blood parameters may vary with nutrition and built of the individual. The purpose of this study was to find out any correlation between anthropometric and hematological parameters after the adolescent growth period. Methods: Total of 81 subjects (males: 20; females: 61), 18-22 years were analyzed for 4 anthropometric measures and 19 hematological markers. Blood was collected in citrate tubes and analyzed for hematological parameters. Results: Difference between BMI sub-groups with respect to hemoglobin (Hb), red cell distribution width-standard deviation (RDW-SD) and red cell distribution width-coefficient of variation (RDW-CV) in males and females was not significant. In males, height showed negative correlation with mean corpuscular hemoglobin concentration (MCHC) and weight showed positive correlation with hematocrit. BMI positively correlated with Hb. Body surface area (BSA) correlated with red blood cell count (RBC) and hematocrit. In females, height, weight and BSA did not show significant correlation with any of the blood parameters. BMI correlated positively with mid-cell fraction and negatively with mean platelet volume. RDW-SD and RDW-CV did not reveal any statistically significant correlation with height, weight, BMI and BSA in both males and females. Conclusion: In male subjects, hemoglobin concentration positively correlated with BMI whereas RBC count and hematocrit correlated with BSA. In females no such association was noted. RDW did not show any correlation with anthropometric measures in both genders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2016b,

title = {Observational study on the prevalence of diabetes mellitus among ultrasonographically diagnosed cholelithiasis patients},

author = {Mohammed Abdul Hannan Hazari and Shadan Taskeen and Mehnaaz Sameera Arifuddin},

url = {https://www.ijcep.org/index.php/ijcep/article/view/264},

doi = {10.4103/2348-8093.185206},

issn = {2348-8093},

year  = {2016},

date = {2016-04-30},

urldate = {2016-01-01},

journal = {International Journal of Clinical and Experimental Physiology},

volume = {3},

issue = {2},

pages = {77-81},

publisher = {EManuscript Technologies},

abstract = {Background and Aim: Diabetes and cholelithiasis are common diseases worldwide in this era of modern epidemics of non - communicable diseases. Studies revealed that diabetes is a risk factor for gallstones. Since both diseases are related to altered carbohydrate and lipid metabolism, we hypothesized that the vice‑versa, i.e., gallstone disease can be a risk factor for the development of diabetes. The aim of this study was to find the prevalence of diabetes mellitus among ultrasonographically diagnosed cholelithiasis patients and to find any correlation between parameters of gallstones and diabetes mellitus. Methods: This was a hospital‑based observational study. A total of 31 gallstone patients belonging to both genders (male = 9, female = 22) and in the age group of 20–80 years were enrolled in the study. From ultrasound report, parameters noted were: size of gallbladder, solitary or multiple gallstones, and size of the largest gallstone. All patients were asked about history of diabetes mellitus, (if history of diabetes is present – whether the diabetes was diagnosed before or after cholelithiasis), monthly family income, education status, and occupation. Data obtained were subjected to appropriate statistical analysis. P < 0.05 was considered statistically significant. Results: In this endeavor, we found that the prevalence of diabetes among cholelithiasis patients was only 35.48%; and of the 11 diabetic patients, 3 developed gallstones before the diagnosis of diabetes mellitus. Socioeconomic status did not have any bearing on the occurrence of diabetes and gallstones in our patients. Glycated hemoglobin levels did not correlate with the severity of gallstone disease which is assessed in the form of solitary/multiple stones and size of the largest gallstone. Conclusion: There is no increased prevalence of diabetes among cholelithiasis patients. Our hypothesis of gallstones acting as risk for developing diabetes could not be proved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2016,

title = {Effect of ongoing isometric handgrip exercise on the inspiratory and expiratory reserve volumes},

author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Mohammed Abdul Haq Junaid and Mohammed Asghar Ali},

url = {https://njppp.com/?mno=220771},

doi = {10.5455/njppp.2016.6.03032016134},

issn = {2320-4672},

year  = {2016},

date = {2016-01-01},

urldate = {2016-01-01},

journal = {National Journal of Physiology, Pharmacy and Pharmacology},

volume = {6},

issue = {4},

pages = {329-332},

publisher = {ScopeMed},

abstract = {Background: Chronic diseases such as hypertension and diabetes have shown improvement in disease condition on isotonic exercises. But the same can cause deterioration in the health of patients with asthma, heart failure, and chronic obstructive pulmonary disease. Therefore, in such individuals, isometric exercise can be given a try. Isometric exercise is known to activate the autonomic nervous system, especially the parasympathetic fibers and thus has a bearing on the functioning of respiratory system.

Aims and Objectives: This study was undertaken with a purpose to find acute change in respiratory reserve during handgrip exercise.

Materials and Methods: 50 young apparently healthy volunteers between the ages of 18 to 35 years were enrolled for the study. Different spirometry volumes and capacities including inspiratory reserve volume (IRV) and expiratory reserve volume (ERV) were recorded on MedSpiror (RMS, Chandigarh, India) at baseline and during sustained hand grip using a hand dynamometer. Statistical analysis was done using SPSS 17.0 on the data obtained.

Result: This study showed that FVC was significantly reduced during handgrip exercise. FEV1, PEFR, FEF 25-75% and IRV decreased while FEV1/FVC and ERV increased but these changes were not significant statistically.

Conclusion: The reserve capacity of the lung does not change significantly during isometric exercise.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid26229751,

title = {Cost-effectiveness analysis of three different combinations of inhalers for severe and very severe chronic obstructive pulmonary disease patients at a tertiary care teaching hospital of South India},

author = {Mohammed Altaf and Ayesha Mubeen Zubedi and Fareesa Nazneen and Shaik Kareemulla and Syed Amir Ali and Mirza Misba Ali Baig and M. Aleemuddin Naveed and Mohammed Abdul Hannan Hazari},

url = {https://journals.lww.com/picp/Fulltext/2015/06030/Cost_effectiveness_analysis_of_three_different.7.aspx},

doi = {10.4103/2229-3485.159940},

issn = {2229-3485},

year  = {2015},

date = {2015-09-30},

urldate = {2015-09-30},

journal = {Perspectives in Clinical Research},

volume = {6},

issue = {3},

pages = {150-158},

publisher = {Wolters Kluwer - Medknow},

crossref = {Altaf_2015},

abstract = {Background: This study aims at simplifying the practical patient management and offers some general indications for pharmacotherapeutic choice by the implementation of (Global Initiative for Chronic Lung Disease) guidelines. This study was designed to evaluate the clinical and economic consequences of salmeterol/fluticasone (SF), formoterol/budesonide (FB), and formoterol/fluticasone (FF) in severe and very severe chronic obstructive pulmonary disease (COPD) patients.

Objectives: The aim was to find out the most cost-effective drug combination between the three combinations (SF/FB/FF) in COPD patients.

Materials and Methods: A prospective observational comparative study (cost-effectiveness analysis), in which 90 severe (30 ≤ forced expiratory volume in 1 s [FEV1] <50% predicted) and very severe (FEV1 < 30% predicted) COPD patients (outpatients/inpatients) who are prescribed with any one of the following combinations (SF/FB/FF) were selected. In our study, we have divided 90 COPD patients into three groups (Group I, Group II, and Group III) each group consisting of 30 patients. Group I was prescribed with medication SF, Group II with medication FB, and Group III with medication FF. We used five different parameters such as spirometry test (mean FEV1 initial and final visit), number of symptom-free days (SFDs), number of moderate and severe exacerbations, Number of days of hospitalization and direct, indirect, and total cost to assess the cost-effectiveness of SF/FB/FF. Comparison of cost and effects was done during the period of 6 months of using SF/FB/FF.

Results: The average FEV1 for Group I, Group II, and Group III subjects at initial visit was 33.47%, 33.73%, and 33.20% and was increased to 36.60%, 35.8%, and 33.4%, respectively. A 3% increment in FEV1 was reported for Group I subjects (SF) and was highly significant statistically (t = −8.833, P = 0.000) at 95% CI. For Group II subjects (FB), a 2% increment in FEV1 was reported and was highly significant statistically (t = −9.001, P = 0.000) at 95% CI. For Group III (FF) subjects 0.2% increment in FEV1. The overall mean total cost for Group I, Group II, and Group III subjects during the 6 months period was found to be Rs. 29,725/-, Rs. 32,602/- and Rs. 37,155/-. Incremental cost-effectiveness of FB versus SF was Rs. 37,781/- per avoided exacerbation and Rs. 661/-per SFD.

Conclusion: This study highlights the favorable therapeutic performance of combined inhaled bronchodilators and corticosteroids (SF/FB/FF), thus suggesting that healthcare costs would be also affected positively. Results from our study showed that SF and FB were the most effective strategies in the treatment of COPD, with a slight clinical superiority of SF. The FF strategy was not much effective (i.e. associated with fewer outcomes and higher costs).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2015,

title = {Cognitive impairment in type 2 diabetes mellitus},

author = {Mohammed Abdul Hannan Hazari and Barra Ram Reddy and Nazia Uzma and Bhaskarpillai Santhosh Kumar},

url = {https://www.sciencedirect.com/science/article/pii/S1877593411000026?via%3Dihub},

doi = {10.1016/j.ijdm.2011.01.001},

issn = {1877-5934},

year  = {2015},

date = {2015-05-01},

urldate = {2015-05-01},

journal = {International Journal of Diabetes Mellitus},

volume = {3},

issue = {1},

pages = {19-24},

publisher = {Elsevier BV},

crossref = {Hazari_2015},

abstract = {Background: Type 2 diabetes mellitus (T2DM) is a modern day epidemic. Chronic course of diabetes is detrimental to the cognitive functions.

Aim: To decipher the pattern of cognitive impairment in relation to the duration of diabetes.

Study design: Cross-sectional.

Material and methods: T2DM patients (Group I: ⩽5 years duration of diabetes, n = 11; Group II: >5 years duration of diabetes, n = 17) without clinical evidence of central nervous system damage and non-diabetic controls (n = 18) were studied clinically and P300 event-related potentials (ERPs) recorded using three stimuli oddball paradigm. Subjects were examined with Folstein mini-mental state examination (MMSE) for cognitive function and those showing scores more than 26 (maximum score = 30) were enrolled for the study. Patients with known diabetic complications were excluded.

Results: P300 latencies in diabetic group did not relate linearly to the duration of diabetes. Diabetic subgroups with ⩽5 years and >5 years duration of diabetes showed striking differences, patients with over 5 years of disease duration had much prolonged P300 latencies in contrast to patients with 5 years or less disease duration who showed trends similar to that of control group. Differences in P300 amplitudes between groups were non-significant. Hypertensive diabetics showed much prolongation in P300 latencies compared to normotensive diabetics.

Conclusions: P300 ERPs revealed cognitive dysfunction which was not detected by neuro-psychometric test (MMSE). Patients with T2DM have decreased cognitive function which is more prominent when the disease duration exceeds 5 years. Co-existence of hypertension with T2DM further increases the risk of cognitive impairment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mahmood_2015,

title = {Liver cirrhosis with ascites: Study on identifying reliability parameters for clinical outcome},

author = {Shaikh Mahmood and Badruz Zama and Mohammed Abdul Hannan Hazari},

url = {https://www.ijpcbs.com/articles/liver-cirrhosis-with-ascites-study-on-identifying-reliability-parameters-for-clinical-outcome.pdf},

issn = {2249-9504},

year  = {2015},

date = {2015-03-31},

urldate = {2015-03-31},

journal = {International Journal of Pharmaceutical, Chemical and Biological Sciences},

volume = {5},

issue = {1},

pages = {71-76},

abstract = {Background: Ascites is one of the major complications of liver cirrhosis which usually develop secondary to portal hypertension.

Aim: The purpose of the current study was to evaluate the utility of ratios of few biochemical parameters between serum and ascetic fluid, whether these ratios are more reliable than the actual parameters in diagnosis and prognosis of these patients.

Study design: Cross-sectional study.

Place and duration of study: Owaisi Hospital and Research Centre, Hyderabad, India from July 2012 to December 2013.

Methodology: Biochemical analysis of serum and ascetic fluid focussed on assessing liver function was done. A total of 350 cirrhotic patients of both genders were screened for ascites and 50 among them fulfilling inclusion and exclusion criteria were enrolled for this study. They were assessed for 34 demographic and laboratory parameters including liver function tests, renal function tests and serum electrolytes. We made an attempt to know whether ratio of some of the biochemical parameters in ascitic fluid-to-serum (AF/S) can be more reliable indicators and better prognostic markers in liver cirrhosis with ascites.

Results and Conclusion: In this endeavour, the AF/S ratios of total proteins, albumin, ADA, LDH, GGT and α-amylase did not showed a clear advantage over the existing biochemical analysis in vogue.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Konuri_2015,

title = {Evolution of automaticity of heart pacemaker studied from a theoretical perspective},

author = {Vijay Kumar Konuri and Mohammed Abdul Hannan Hazari and K. Ravi Kumar and M. Chandrasekhar and K. Ambareesha and Barra Ram Reddy},

url = {https://www.ijmrhs.com/abstract/evolution-of-automaticity-of-heart-pacemaker-studied-from-a-theoretical-perspective-163.html},

doi = {10.5958/2319-5886.2015.00077.6},

issn = {2319-5886},

year  = {2015},

date = {2015-03-01},

urldate = {2015-03-01},

journal = {International Journal of Medical Research & Health Sciences},

volume = {4},

issue = {2},

pages = {417-421},

abstract = {The pacemaker of the mammalian heart had developed a robust and yet a flexible system in the course of evolution whose function is based on multiple interactions at the sub-cellular, cellular and finally at the tissue level. These, in turn, should respond to extrinsic signals. Cardiac action potentials were explained for a long time based on the changes that occur at the cell surface. New hypothesis was put forward at the turn of the century that pointed to the role of intracellular calcium clock. Discovery of ryanodine receptors, fluorescence labeling techniques, confocal imaging and finally computer modeling of physiological processes had brought about a noticeable change that allowed development of a new concept of pacemaker automaticity. Reviewing all these developments we hereby put forward a few theoretical formulations that can turn out to be new instruments in advancing our knowledge of cardiac physiology. We had theorized that cardiac muscle is an emergent property of smooth muscle in the course of evolution, and that pacemaker activity of the cardiac muscle underwent a phase transition that finally led to the evolution of a structural pacemaker.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rani_2015,

title = {Levels of upper limit of oxidative stress markers during normal pregnancy and pre-eclampsia},

author = {Damrela Usha Rani and Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari and R. Haragopal and Barra Ram Reddy},

url = {https://jmscr.igmpublication.org/home/index.php/archive/114-volume-3-issue-01-jan-2015#download-pdf-19},

issn = {2347-176X},

year  = {2015},

date = {2015-01-31},

journal = {Journal of Medical Science and Clinical Research},

volume = {3},

issue = {1},

pages = {3674-3682},

publisher = {IGM Publication},

abstract = {Background: the reactive oxygen species (ROS) are involved in multiple reproductive processes – maturation of oocyte, fertilization, development of embryo, pregnancy and parturition. However, the optimal levels and interplay of oxidants and antioxidants is crucial for a positive pregnancy outcome. Pregnancy induced hypertension (PIH) is shown to have defective trophoblast invasion leading to high pressures in utero-placental circulation; thus this stress imposed on placenta may disturb the oxidant-antioxidant balance.

Aim: the purpose of this study was to assess the oxidative stress during uncomplicated pregnancy and pregnancy associated with hypertension in primi-gravida women.

Materials and methods: a total of 90 women were enrolled and divided into 3 groups. Group 1: Healthy non-pregnant women (n=30), Group 2: Normotensive primi-gravida women (n=30) and Group 3: Pre-eclamptic primi-gravida women (n=30). Blood samples were analyzed for levels of malondialdehyde (MDA), superoxide dismutase (SOD), total anti-oxidant capacity (TAC) and uric acid using appropriate biochemical methods. ANOVA was used for assessing the difference between the groups and statistical significance was fixed at p<0.05.

Results: in the present study, levels of MDA, SOD and uric acid were significantly increased in pregnant compared to non-pregnant women and to a greater extent in pre-eclampsia women compared to normal pregnant women.TAC levels were significantly decreased in pregnant when compared to non-pregnant and much more decreased in pre-eclampsia women compared to normal pregnant women.

Conclusion: high pressures in feto-placental circulation can lead to increased elaboration of oxidative radicals which may cause oxidative damage to placenta and other organs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Maaz_2014,

title = {Training in the use of inhalation devices and respiratory improvement in asthma and COPD patients: A before-after experimental study},

author = {Mohammed Maazuddin and Mohammed Abdul Hannan Hazari and Ashfaq Hasan and Mohd. Javeedullah and Mohd. Nasir Mohiuddin and Mirza Misba Ali Baig},

url = {https://www.researchgate.net/publication/272944333_Training_in_the_use_of_inhalation_devices_and_respiratory_improvement_in_asthma_and_COPD_patients_A_before-after_experimental_study},

issn = {2231-0541},

year  = {2014},

date = {2014-11-01},

journal = {PHARMANEST},

volume = {5},

issue = {5},

pages = {2314-2320},

abstract = {Objective: The aim of the study was to assess the effectiveness of one-time personalized intervention by pharmacists in the form of training in correct inhaler technique. Methods: 104 asthma and COPD patients attending the out-patient department Pulmonary Medicine of a medical college hospital in Hyderabad were recruited for the study. At two different visits, patients were assessed for their respiratory status, importance of treatment and inhaler technique. After assessment at the first visit, patients were given one-time health education about the disease and the correct inhaler technique was demonstrated by hospital based pharmacists. Comparisons were made between the two visits for respiratory status using St. George’s Respiratory Questionnaire. We used students‘t’ test for comparing the results. Results: There was reduction in SGRQ scores irrespective of the device used which shows the effectiveness of one-time health education and training. The changes in SGRQ scores were found to be statistically significant with all devices except with use of Rotahaler and Starhaler. Conclusion: Inhalation technique of patients is usually poor regardless of the device prescribed, and educational intervention with the demonstration of the sequential steps involved in particular inhaler results in significant improvement in inhalational technique. Intervention by hospital based pharmacists proved more effective than the verbal instructions given in the physician’s consultation room. Therefore, sufficient time should be devoted for a practical demonstration of inhaler technique after prescribing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{David_2014,

title = {Does teaching experience influence personality types and teaching styles of faculty in a medical college},

author = {M. Anthony David Swaroop Kumar and Mehnaaz Sameera Arifuddin and Farah Bahmed and Mohammed Abdul Hannan Hazari and Syed Azherullah Quadri and Samreen Fathima and Hassan Bin Ali},

url = {https://www.researchgate.net/publication/267040515_Does_teaching_experience_influence_personality_types_and_teaching_styles_of_faculty_in_a_medical_college},

year  = {2014},

date = {2014-07-31},

journal = {International Journal of Health and Education},

volume = {3},

issue = {1},

pages = {56-62},

abstract = {The aim of this study was to determine if there is any influence of teaching experience on personality types and teaching styles of faculty members in a medical college. A total of 35 teachers of pre- and para-clinical departments of a medical college participated in this study. Their personality types and teaching styles were determined using appropriate

questionnaires. Their experience in years of teaching was used to divide them into 2 groups; Group 1: with less than and equal to 5 years and Group 2: more than 5 years teaching experience. Analyses were done using appropriate statistical methods. The study shows that the percentage of teachers who have extroverted personality type with an

expert style of teaching is more in Group 2 when compared to Group 1. Experience, expertise and appropriate teaching styles might help in bettering medical education in general.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2014,

title = {Baroreceptor and chemoreceptor reflex contribution in cardiovascular changes during exercise},

author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Ayesha Farheen and Irshad Hussain Askari},

url = {https://www.researchgate.net/publication/267985135_Baroreceptor_and_Chemoreceptor_Reflex_Contribution_in_Cardiovascular_Changes_during_Exercise},

doi = {10.5958/2320-608x.2014.00009.2},

issn = {2320-6039},

year  = {2014},

date = {2014-07-01},

urldate = {2014-07-01},

journal = {International Journal of Physiology},

volume = {2},

issue = {2},

pages = {36-41},

publisher = {Institute Medico-legal Publication},

crossref = {Hazari_2014},

abstract = {During exercise, both baroreceptors and chemoreceptors contribute in bringing about the cardiovascular changes, but less is documented about the contribution made by either of these mechanisms. The purpose of the present study was to demonstrate the differential effects of baroreceptors and chemoreceptors on cardiovascular parameters during exercise. Twelve healthy individuals were subjected to exercise maneuver on stationary cycling machine. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and electrocardiogram (ECG) were recorded during rest and immediately after exercise. Heart rate (HR) and heart rate variability (HRV) was computed from ECG. SBP, DBP, mean arterial blood pressure (MABP) and HR significantly increased due to exercise. Increase in SBP, DBP, Pulse pressure (PP), MABP and HR were more pronounced when chemoreceptor influence was not considered as against when changes due to both baroreceptors and chemoreceptors were considered. The HRV analysis reflected increase in the low-frequency (LF) power % and decrease in high-frequency (HF) power % along with reduction in LF/HF ratio due to exercise, but these

changes were statistically not significant. Baroreceptors through baroreflex mechanism overall increase the CVS parameters. The novel finding in this study was the opposing action of chemoreceptor mechanism to that of baroreceptor mechanism in cardiovascular homeostasis during exercise. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2014b,

title = {Integrated teaching in medical curriculum in India},

author = {Mohammed Abdul Hannan Hazari},

url = {https://www.researchgate.net/publication/267987893_Integrated_teaching_in_medical_curriculum_in_India},

doi = {10.18035/emj.v2i3.170},

issn = {2307-7301},

year  = {2014},

date = {2014-07-01},

urldate = {2014-07-01},

journal = {El Mednifico Journal},

volume = {2},

issue = {3},

pages = {314},

publisher = {El Mednifico Journal},

keywords = {},

pubstate = {published},

tppubtype = {article}

}