@article{Altaf_2014,

title = {Cost-effectiveness analysis of combined inhaled corticosteroids and bronchodilators for severe and very severe COPD patients in a teaching hospital},

author = {Mohammed Altaf and Ayesha Mubeen Zubedi and Fareesa Nazneen and Shaik Kareemulla and Syed Amir Ali and Mirza Misba Ali Baig and Arshad Hussain Mohd and M. Aleemuddin Naveed and Mohammed Abdul Hannan Hazari and Syed Abdul Azeez},

url = {http://iosrphr.org/papers/v4i06/Part_2/C04602012023.pdf},

doi = {10.9790/3013-040602012023},

issn = {2250-3013},

year  = {2014},

date = {2014-06-30},

urldate = {2014-01-01},

journal = {IOSR Journal of Pharmacy (IOSRPHR)},

volume = {4},

issue = {6},

pages = {12-23},

publisher = {IOSR Journals},

crossref = {Altaf_2014},

abstract = {BACKGROUND: This study aims at simplifying the practical patient management and offers some general indications for pharmacotherapeutic choice by the implementation of (GOLD 2004) guidelines. This study was designed to evaluate the clinical and economic consequences of Salmeterol/Fluticasone(SF), Formoterol/Budesonide(FB) and Formoterol/Fluticasone(FF) in severe and very severe COPD patients. 

OBJECTIVES: To find out the most cost-effective drug combination between the three combinations (SF/FB/FF) in COPD patients. 

METHODS: A Prospective observational Comparative study (Cost-effectiveness Analysis) in which 90 severe (30≤FEV1<50% predicted) and very severe (FEV1<30% predicted) COPD patients (OP/IP) who are prescribed with any one of the following combinations (SF/FB/FF) were selected. In our study we have divided 90 COPD patients into 3 groups (Group I, Group II & Group III) each group consisting of 30 patients. Group I was prescribed with medication SF (salmeterol/fluticasone), Group II with medication FB (formoterol/budesonide) and Group III with medication FF (formoterol/fluticasone). We used five different parameters such as Spirometry test (mean FEV1 initial & final visit), Number of symptom free days, Number of moderate & severe exacerbations and Direct, indirect & total cost to assess the cost-effectiveness of SF/FB/FF. Comparison of cost and effects was done during the period of 6 months of using SF/FB/FF. RESULTS: The average FEV1 for group I, group II and group III subjects at initial visit was 33.47%, 33.73% & 33.20% and was increased to 36.60%, 35.8% and 33.4% respectively. A 3% increment in FEV1 was reported for group I subjects (SF) and was highly significant statistically (t=-8.833},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2014,

title = {Does the teaching performance of faculty in Physiology change over the years?},

author = {Mehnaaz Sameera Arifuddin and Farah Bahmed and M. Anthony David Swaroop Kumar and Mohammed Abdul Hannan Hazari},

url = {https://eduimed.usm.my/EIMJ20140601/EIMJ20140601_09.pdf},

doi = {10.5959/eimj.v6i1.183},

issn = {2180-1932},

year  = {2014},

date = {2014-03-01},

urldate = {2014-03-01},

journal = {Education in Medicine Journal},

volume = {6},

issue = {1},

pages = {e56-e61},

publisher = {Penerbit Universiti Sains Malaysia},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2013b,

title = {Neural modulation of inflammation},

author = {Mehnaaz Sameera Arifuddin and K. Sai Krishna and Mohammed Abdul Hannan Hazari and B. Dinesh Kumar},

url = {http://www.jbpr.in/index.php/jbpr/article/view/712},

issn = {2279-0594},

year  = {2013},

date = {2013-06-28},

journal = {Journal of Biomedical and Pharmaceutical Research},

volume = {2},

issue = {3},

pages = {109-113},

abstract = {Background: In the present situation of emerging cases of drug allergies, auto-immune disorders and adverse

reactions to anti-inflammatory drugs, there is a need to find an alternative for handling abnormal immune status

which causes inflammatory storm. There is a growing need to exploit the nervous system for understanding the

role played by neurons in the inflammatory process.

Aims and objectives: The purpose of this study was to understand the anti-inflammatory role of parasympathetic

nervous system using Bethanechol chloride and to study the contribution of neurons in modulating inflammation

using 2% Carrageenan.

Materials and methods: Thirty female Wistar (WNIN) rats were selected for this study. Twenty five WNIN rats,

divided into five groups were selected for studying the anti-inflammatory activity of Bethanechol chloride. The

remaining five rats were selected to elicit the inter-dependent natures of immune and nervous systems. 2%

Carrageenan was injected in both the hind paws. In both the study protocols, increase in paw volume was

measured using plethysmometer and subjected to calculations.

Results: A significant anti-inflammatory activity of Bethanechol chloride compared to control group was observed.

In the other part of study, the right paw, in which Carrageenan re-constituted in Lidocaine was injected, showed

nearly no signs of inflammation in the initial hours, while left paw injected with Carrageenan dissolved in distilled

water presented with a typical Carrageenan-induced paw oedema. However, one to two hours later (which

corresponds to the half-life of Lidocaine), the right paw also showed the same degree of oedema.

Conclusion: We conclude that Bethanechol chloride has anti-inflammatory activity at small doses, and therefore

can be used as an adjuvant in the treatment of chronic inflammatory disorders. This study also shows that immune

system works in conjunction with the nervous system in modulating inflammation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2013,

title = {Effects of age and gender on cognitive functions as assessed by p300 potentials},

author = {Mehnaaz Sameera Arifuddin and Keerthana Kota and Mohammed Abdul Hannan Hazari and Barra Ram Reddy},

url = {https://www.biomedscidirect.com/journalfiles/IJBMRF20131071.pdf},

issn = {0976-6685},

year  = {2013},

date = {2013-03-31},

journal = {International Journal of Biological and Medical Research},

volume = {4},

issue = {1},

pages = {2910-2914},

abstract = {Background: Higher mental functions decline as age advances, sometimes leading to overt dementia which compromises an individual's day-to-day activities. Contrary to this, some elderly individuals show remarkable intellectual capabilities, which drive our attention to the factors apart from age that are detrimental to cognitive functions. Gender is an important factor that needs to be considered while assessing cognitive functions.

Aims and objectives: The aim of the present study was to interpret the pattern of cognitive decline with respect to

age and to compare the difference in cognitive potentials among males and females.

Materials and methods: The study was conducted on 61 apparently healthy subjects. Subjects were divided into 5 sub-groups based on age(Group I: 16-25 years, Group II: 26-35 years, Group III: 36-45 years, Group IV: 46-55 years and Group V: 56-65 years). The p300 cognitive potentials were recorded using Nicolet Viking Select (Viasys Healthcare, U.S.A.).

Results: The p300 latencies exhibited increasing trend and p300 amplitudes showed decreasing trends in the

consecutive age groups. However, the change between the consecutive age groups was statistically not significant. Also, in the corresponding age groups, there was no significant difference between males and females.

Conclusions: The increasing trend in the p300 latencies indicate subtle decline in cognitive functions though these changes were not statistically significant. We also conclude that there is no gender disparity in the cognitive performance in the same age group.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid23181228,

title = {Serum calcium level in hypertension},

author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin and Syed Muzzakar and Vontela Devender Reddy},

doi = {10.4103/1947-2714.103316},

issn = {1947-2714},

year  = {2012},

date = {2012-11-01},

urldate = {2012-11-01},

journal = {North American Journal of Medical Sciences},

volume = {4},

issue = {11},

pages = {569-572},

abstract = {BACKGROUND: The alterations in extracellular calcium level may influence intracellular calcium level and possibly play a role in the pathogenesis of essential hypertension.



AIM: The purpose was to find out the association between serum calcium levels and hypertension; and to compare the serum calcium levels between normotensive controls, hypertensive subjects on calcium channel blockers, and hypertensive subjects on antihypertensive medication other than calcium channel blockers.



MATERIALS AND METHODS: Thirty one individuals including normotensives (n = 12) and hypertensives (n = 19) were enrolled for the study and their blood pressure recorded. Hypertensive group was sub divided into two: hypertensives on calcium channel blockers and hypertensives on antihypertensive medication other than calcium channel blockers. Serum calcium levels were measured by Accucare Calcium Arsenazo III kit. Differences between the groups were analyzed using ANOVA.



RESULTS: No significant difference in serum calcium level was found between normotensive and hypertensive groups; and no correlation was found between calcium levels and the blood pressure. Also the difference in serum calcium levels in hypertensive group on calcium channel blockers and those on antihypertensive other than calcium channel blockers was insignificant.



CONCLUSIONS: Serum calcium levels are tightly regulated. Subtle changes in serum levels do not affect blood pressure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2012,

title = {Blood pressure variations during different phases of menstrual cycle},

author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari and Barra Ram Reddy},

url = {http://www.scienceandnature.org/IJSN/IJSN_Vol3(3)S2012/IJSN-VOL3(3)12-14.pdf},

issn = {0973-3140},

year  = {2012},

date = {2012-08-10},

journal = {International Journal of Science and Nature},

volume = {3},

issue = {3},

pages = {551-554},

publisher = {Society For Science and Nature},

abstract = {Blood pressure (BP) is not constant throughout the day, on different days in a month and on different times of a

cyclical event like menstrual cycle. Variation in BP during different phases of menstrual cycle can also be attributed

to the effect of female sex hormones on cardiovascular function. The purpose of this study was to evaluate the

variation in BP during different phases of menstrual cycle and whether these changes can warrant an increase or

decrease in the dose of antihypertensive drugs in hypertensive women of reproductive age group. This study was

conducted on a healthy female subject with regular menstrual cycle of 28 days duration using ambulatory BP monitor

(TM-2430, A&D Co., Japan). 24-hour BP was recorded on alternate days for a period of 2 consecutive menstrual

cycles. BP data was divided into four groups: menstrual phase (days 2 and 4), proliferative phase (days 6, 8, 10 and

12), ovulatory phase (day 14) and secretory phase (days 16, 18, 20, 22, 24, 26 and 28). Though the differences were

noted between different phases of menstrual cycle, they were not statistically significant. To conclude, cardiovascular

homeostatic mechanisms are strong enough to correct the subtle BP changes brought about by the action of ovarian

hormones on the cardiovascular system.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22465897,

title = {Cardiovascular autonomic dysfunction in type 2 diabetes mellitus and essential hypertension in a South Indian population},

author = {Mohammed Abdul Hannan Hazari and Reddipalli Tajuddin Khan and Barra Ram Reddy and Mohammed Abrar Hassan},

url = {https://nsj.org.sa/content/17/2/173},

issn = {1319-6138},

year  = {2012},

date = {2012-04-01},

urldate = {2012-04-01},

journal = {Neurosciences (Riyadh)},

volume = {17},

issue = {2},

pages = {173-175},

publisher = {Saudi Medical Journal},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid20886531,

title = {Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers},

author = {Nazia Uzma and Bhaskarpillai Santhosh Kumar and Mohammed Abdul Hannan Hazari},

doi = {10.1002/ajim.20901},

issn = {1097-0274},

year  = {2010},

date = {2010-12-01},

urldate = {2010-12-01},

journal = {American Journal of Industrial Medicine},

volume = {53},

issue = {12},

pages = {1264-1270},

publisher = {John Wiley & Sons},

abstract = {BACKGROUND: Chronic exposure to benzene can lead to deleterious effects on many biological systems including blood and blood-forming organs. We investigated the adverse effects of benzene among workers occupationally exposed to benzene in India.



METHODS: Four hundred twenty-eight gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals were recruited for this study. Benzene concentration was determined by gas chromatography, reactive oxygen species (ROS) by dichlorofluorescin diacetate (DCFH-DA) method, malondialdehyde (MDA) by thiobarbituric acid reactive substances assay (TBARS), total superoxide dismutase (T-SOD) by RANSOD kit and glutathione (GSH) by 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) reaction, respectively. CD4, CD8, IgG were carried out by using fluorescence activated cell sorter (FACS Calibur) and mRNA expression of p53 by reverse transcriptase PCR (RT-PCR).



RESULTS: A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. The levels of ROS and MDA were significantly elevated, and GSH and total T-SOD were decreased in the workers compared with the controls. A statistically significant decrease in the immunoglobulin levels, CD4T cells, CD4/CD8 ratio was observed in workers (vs. controls), whereas no significant difference was observed in CD8T cells. p53 gene expression was markedly higher in workers than in controls.



CONCLUSION: Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Cardiovascular autonomic neuropathy in patients with diabetes mellitus},

author = {Nazeema Khatoon and Bhaskarpillai Santhosh Kumar and Mohammed Abdul Hannan Hazari},

url = {https://www.ijpbs.net/abstract.php?article=NTI0},

issn = {0975-6299},

year  = {2010},

date = {2010-09-01},

urldate = {2010-09-01},

journal = {International Journal of Pharma and Biosciences},

volume = {1},

issue = {3},

abstract = {The cardioautonomic reflexes of 82 diabetic subjects and 40 age and sex matched healthy controls were studied using blood pressure and heart rate variation in response to standing, deep breathing, isometric exercise, cold pressor test and determination of QTc interval. Among the 82 patients, 68 patients were found to have cardiac autonomic neuropathy (CAN). Results showed that diabetics had significantly impaired cardioautonomic reflexes compared to non-diabetics, which increases with the duration of diabetes. Out of 68 patients with CAN, QTc prolongation was observed in 64 patients. In conclusion the autonomic nervous system integrity is appeared to be greatly affected by diabetes mellitus and the degree of impairment was dependent on duration of the disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}