@article{Raheem_2022b,

title = {Role of neutrophil-lymphocyte ratio as a predictive marker in the diagnosis of acute coronary syndrome},

author = {Mariyah Raheem and Asiya Tabassum and Atiya Begum},

url = {https://www.ijsr.net/getabstract.php?paperid=SR22728102305},

issn = {2319-7064},

year  = {2022},

date = {2022-08-31},

urldate = {2022-08-31},

journal = {International Journal of Science and Research},

volume = {11},

issue = {8},

pages = {257-261},

abstract = {Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight femalepreponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if P<0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022b,

title = {Covid-19 vs dengue-role of WBC counts in segregation of cases at an early stage with special reference to NLR as a diagnostic and prognostic factor},

author = {Asiya Tabassum and Idrees Akhtar Afroze and Sumayya Begum },

url = {https://www.ijmsir.com/asset/images/uploads/16560077756647.pdf},

issn = {2458-868X},

year  = {2022},

date = {2022-05-31},

urldate = {2022-05-31},

journal = {International Journal of Medical Science and Innovative Research},

volume = {7},

issue = {3},

pages = {155-162},

abstract = {Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the

initial stages but have different clinical management which makes it challenging for the health care  professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done

decreasing the mortality and for better outcome of these patients. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shamshuddeen_2022,

title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},

author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},

url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},

doi = {10.53730/ijhs.v6ns3.7623},

issn = {2550-696X},

year  = {2022},

date = {2022-05-20},

urldate = {2022-05-20},

journal = {International Journal of Health Sciences},

volume = {6},

issue = {S3},

pages = {6963-6971},

publisher = {Universidad Tecnica de Manabi},

abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022,

title = {Evaluation of platelet indices in dengue seropositive cases at a tertiary care hospital in Hyderabad},

author = {Asiya Tabassum and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-platelet-indices-in-dengue-seropositive-cases-at-a-tertiary-care-hospital-in-hyderabad-_January_2022_8361510941_2433857.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2022},

date = {2022-01-31},

urldate = {2022-01-31},

journal = {International Journal of Scientific Research},

volume = {11},

issue = {1},

pages = {48-49},

abstract = {Background: Dengue is caused by an arbovirus and is transmitted by mosquito Aedes aegypti. In addition to platelet count, Platelet indices like Mean platelet volume (MPV), Platelet distribution width (PDW) ,Plateletcrit (PCT ) and Platelet large cell ratio (P-LCR) are being investigated as prospective platelet activation indicators. Aims And Objectives: To evaluate the role of platelet indices in dengue seropositive cases. Materials And Methods: This study was a retrospective one conducted on dengue seropositive cases in Department of pathology, Deccan College of medical sciences, Hyderabad. Cases were collected from Dept of medicine and pediatrics over a period of 2 months in Oct-Nov 2021. Blood samples were processed on Sysmex XN 550 automated cell counter and platelet counts were cross checked manually. Results: In this study, Out of 350 samples received, 1OO patients were found to be positive for dengue serology. Male: Female ratio was 1.3:1 with average age being 7.5years .60 % cases had platelet counts below 50,000/cumm. Among platelet indices, 72 % of the patients had mean platelet volume (MPV) less than 8.5; 84 % cases had Plateletcrit less than 0.22 %; 80 % had platelet distribution width (PDW) more than 25  and P-LCR was increased in 56% cases. Conclusion: We observed signicant correlation of low platelet count with MPV, PCT, PDW and P-LCR. MPV is a marker of platelet function and activation, high MPV indicates increased megakaryocytic activity whereas low MPV indicates marrow suppression. PDW is an indicator of platelet anisocytosis and has a negative correlation with low platelet count. P-LCR is inversely related to platelet count and directly related to PDW. It is decreased in patients with thrombocytosis and increased in thrombocytopenia. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}