@article{Ahmed_2024,

title = {A comprehensive analysis of clinical characteristics, microbial profile, prognostic indicators, and treatment in patients with type 2 diabetes mellitus and acute pyelonephritis},

author = {Syed Faiz Ahmed and Mohammed Khaja Arifuddin},

url = {https://www.jcdronline.org/admin/Uploads/Files/659e8cded4aae5.77075932.pdf},

doi = {10.48047/jcdr.2024.15.01.55},

issn = {0975-3583},

year  = {2024},

date = {2024-01-11},

journal = {Journal of Cardiovascular Disease Research},

volume = {15},

issue = {1},

pages = {496-505},

abstract = {Background: Pyelonephritis is frequently linked to diabetes mellitus, serving as a common cause. Poor outcomes are associated with both emphysematous pyelonephritis (EPN) and non-emphysematous pyelonephritis (NEPN). This study was conducted to examine the clinical characteristics, microbiological profile, prognostic factors, and treatment outcomes of pyelonephritis specifically in diabetic patients.

Methods: Acute pyelonephritis is considered present when a patient experiences fever with chills, rigors, flank pain, nausea, and vomiting. A diagnosis is confirmed through USG and KUB studies showing an enlarged kidney, collection presence, and perinephric fat stranding. Urine samples are collected through midstream voiding, catheterization, or suprapubic needle aspiration. A positive urine culture indicates >105 CFU/ml of bacteria. Glycemic control is classified as good (HbA1c <7%), moderate (HbA1c 7-7.5%), or poor (HbA1c >7.5%). Emphysematous pyelonephritis classification is based on CT scan findings.

Results: In a study of 40 patients with acute pyelonephritis and type 2 diabetes, 80% had non-emphysematous pyelonephritis (NEPN) and 20% had emphysematous pyelonephritis (EPN). Over 75% in both groups experienced loin pain, a hallmark of acute pyelonephritis. Burning micturition affected 75% of EPN and 28.12% of NEPN patients. Less than 15% reported decreased urine output and vomiting in both groups. The NEPN group had significantly lower rates of burning micturition, possibly indicating a link to pyelonephritis severity. In EPN patients, 75% had normal CECT KUB findings, with 50% of abnormalities falling into Class 3A. Approximately 50% of both groups were treated without IV antibiotics, with conservative management dominating. Other interventions, including DJ stents, antifungals, hemodialysis, percutaneous nephrolithotomy, and ureteroscopy with stenting, were also employed.

Conclusion: Diagnosing emphysematous pyelonephritis (EPN) in diabetic patients with pyelonephritis symptoms, particularly with poorly controlled blood sugars, requires a high suspicion index and early imaging. Most affected individuals are aged 51-70 years. Cases of both non-emphysematous (NEPN) and EPN are predominantly associated with gram-negative bacteria. EPN patients in Class I-IIIA respond well to antibiotics or additional percutaneous drainage (PCN), while Class IIIB and Class IV cases may require nephrectomy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2023b,

title = {Effects of tuberculosis on genitourinary system},

author = {Mohammed Khaja Arifuddin and Syed Faiz Ahmed},

url = {https://www.jcdronline.org/paper.php?slug=effects-of-tuberculosis-on-genitourinary-system},

doi = {10.48047/jcdr.2023.14.12.265},

issn = {0975-3583},

year  = {2023},

date = {2023-12-31},

urldate = {2023-12-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {12},

pages = {2291-2299},

abstract = {Background: Genitourinary Tuberculosis (GUTB) is a common site of extrapulmonary tuberculosis. The disease involves the kidneys, ureters, bladder, or genital organs. Clinical symptoms develop 10 – 15 years after primary infection. Only one-quarter of patients with GUTB have a known history of TB and about half of these patients have chest radiography findings. The current study aimed to determine the effects of GUTB.

Methods: The included patients were successive cases with a diagnosis of genitourinary tuberculosis. A total of 62 cases were reported with the diagnosis of genitourinary tuberculosis. PCR for MTb was done in 37 cases. Radiological evaluation included chest X-ray, KUB in all cases, and intravenous urogram when serum creatinine was normal. FNAC was performed in cases with serosal masses. All patients received antitubercular drug therapy with 4 drugs (Rifampicin, Ethambutol, Isoniazid, and Pyrazinamide) for 2 months followed by 2 drugs (Rifampicin and Isoniazid) for 7 months.

Results: Positive AFB staining and positive MTb culture in urine were seen in 31.37% and 41.17% of cases, respectively, confirming the presence of Mycobacterium tuberculosis in some GUTB patients. Positive PCR for MTb in urine is present in 67.56% of cases (in a subset of 37 patients). MTb culture in pus is only observed in 4 out of 7 cases, suggesting its less frequent occurrence compared to other positive findings. Sterile urine is found in 78.95% of cases, and Radiological abnormalities (IVU/NCCT/MUCG) suggestive of GUTB was found in 46/57 (80.7%) cases. Bladder biopsy was positive in 12/25(48%) cases done. A comparison of urinary PCR with urine for AFB staining urine for MTb culture and bladder biopsy was done.

Conclusion: The urinary (PCR) stands out as the most sensitive indicator among all microbiological tests. When coupled with radiological abnormalities, it significantly expedites the diagnosis of genitourinary tuberculosis. Optimal treatment involves a combination of multidrug chemotherapy and judicious surgery, as necessary. It is highly advisable to make every effort to reconstruct the urinary tract due to the rewarding outcomes associated with this approach. However, in cases where tissue is infected and irreparably damaged, the most effective course of action is ablating the affected tissue.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Iqubal_2023,

title = {Study of testosterone levels in type II diabetes mellitus male patients in Telangana population},

author = {Mohammed Asif Muzaffer Iqubal and Mohammed Mudassir Ali and Mohammed Muneer Ahmed and Juwairia Mohammed Fariduddin},

url = {https://ijpcr.com/volume15issue10/},

issn = {0975-1556},

year  = {2023},

date = {2023-10-19},

journal = {International Journal of Pharmaceutical and Clinical Research},

volume = {15},

issue = {10},

pages = {309-313},

abstract = {Background: Type-II DM affects millions of people in India and globally, but the association between serum testosterone levels (STL) and type-II DM is still unclear, but it impairs reproductive health and quality of life. Method: 95 (ninety-five) type II DM patients of different age groups were studied and compared with 90 normal (controlled) groups. The blood investigation included FBS, PP Blood sugar, Blood urea, serum creatinine, HBA1C, lipid profile, urine albumin, creatinine ratio, serum testosterone were estimated by chemiluminesience immune assay and HbA1c by HPLC. Results: The BMI, age, HBA1C, and serum testosterone level were compared with the control group, and the p value was highly insignificant (p<0.001). Conclusion: The present pragmatic study has confirmed that type II DM patients have significantly lower testosterone and higher sugar level was proved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2023b,

title = {Diffusion restriction in bilateral thalami: beyond artery of percheron infarct},

author = {Sandhya Manorenj and Reshma Sultana Shaik and Sravan Kumar Marupaka and Tasneem Ara},

url = {https://journals.lww.com/neur/fulltext/2023/71040/diffusion_restriction_in_bilateral_thalami__beyond.22.aspx},

doi = {10.4103/0028-3886.383876},

issn = {0028-3886},

year  = {2023},

date = {2023-08-18},

urldate = {2023-08-18},

journal = {Neurology India},

volume = {71},

issue = {4},

pages = {754-759},

publisher = {Medknow},

abstract = {Background: Bilateral thalamic infarction, especially the medial thalamus, has been characteristically described in the artery of Percheron (AOP) affection. However, bilateral thalamic restriction has been described in many entities beyond the AOP infarction. Objective: Here we describe a case series (three cases) with infection as an etiology for bilateral thalamic lesions in the topographic distribution of the AOP from a tertiary care center in tropical India. Materials and Methods: Case series during a 1-year period collecting cases with bilateral thalamic diffusion restriction on MRI who did not have thalamic infarcts and their outcomes. Results: Bilateral thalamic lesion can occur in both bacterial and viral infections such as tuberculosis, dengue, and SARS-COV-2. Thus, we intend to add infections as one of the etiologies in the ever-expanding list of conditions that produce bilateral thalamic restriction. Conclusions: All the acute symmetric thalamic lesions are not always secondary to vascular insult. Accurate assessment and prompt diagnosis can prevent unnecessary delays in treatment. To our knowledge, this is the first case series in the literature that throws light on the bilateral thalamic lesions in the topographic distribution of the AOP secondary to infections in a tropical country like India.},

key = {pmid37635510},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2023,

title = {A comprehensive review on neuroendocrine neoplasms: Presentation, pathophysiology and management},

author = {Qamar Sultana and Jill Kar and Amogh Verma and Shreya Sanghvi and Nirja Kaka and Neil Patel and Yashendra Sethi and Hitesh Chopra and Mohammad Amjad Kamal and Nigel H. Greig},

url = {https://www.mdpi.com/2077-0383/12/15/5138},

doi = {10.3390/jcm12155138},

issn = {2077-0383},

year  = {2023},

date = {2023-08-05},

urldate = {2023-08-01},

journal = {Journal of Clinical Medicine},

volume = {12},

issue = {15},

pages = {5138},

publisher = {MDPI AG},

abstract = {Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with neuroendocrine differentiation that can arise from any organ. They account for 2% of all malignancies in the United States. A significant proportion of NEN patients experience endocrine imbalances consequent to increased amine or peptide hormone secretion, impacting their quality of life and prognosis. Over the last decade, pathologic categorization, diagnostic techniques and therapeutic choices for NENs—both well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs)—have appreciably evolved. Diagnosis of NEN mostly follows a suspicion from clinical features or incidental imaging findings. Hormonal or non-hormonal biomarkers (like serum serotonin, urine 5-HIAA, gastrin and VIP) and histology of a suspected NEN is, therefore, critical for both confirmation of the diagnosis and classification as an NET or NEC. Therapy for NENs has progressed recently based on a better molecular understanding, including the involvement of mTOR, VEGF and peptide receptor radionuclide therapy (PRRT), which add to the growing evidence supporting the possibility of treatment beyond complete resection. As the incidence of NENs is on the rise in the United States and several other countries, physicians are more likely to see these cases, and their better understanding may support earlier diagnosis and tailoring treatment to the patient. We have compiled clinically significant evidence for NENs, including relevant changes to clinical practice that have greatly updated our diagnostic and therapeutic approach for NEN patients.},

key = {pmid37568540},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rout_2023,

title = {Assessment of left ventricular filling pressure and its correlation with severity of chronic kidney disease},

author = {Siddhartha Rout and Mohammed Mudassir Ali and Amritarnav Rout and Mohammed Asif Muzaffer Iqubal},

url = {https://ejmcm.com/issue-content/assessment-of-left-ventricular-filling-pressure-and-its-correlation-with-severity-of-chronic-kidney-disease-2639},

issn = {2515-8260},

year  = {2023},

date = {2023-02-28},

journal = {European Journal of Molecular & Clinical Medicine},

volume = {10},

issue = {2},

pages = {1098-1103},

abstract = {Background:Chronic kidney disease (CKD) is a common health problem worldwide. Cardiovascular disease is the most common cause of morbidity and mortality in CKD. In CKD patients, use of Echocardiography can help in establishing a diagnosis of acute decompensated heart failure. Present study was aimed to assessment of left ventricular filling pressure and its correlation with severity of chronic kidney disease. Material and Methods: Present study was single-center, prospective, observational study, conducted patients aged >18 years, either gender, diagnosed cases of CKD as per KIDGO criteria underwent resting 2-D transthoracic echocardiography. Results: In present study, 80 cases of CKD underwent 2-D transthoracic echocardiography evaluation. Majority were from 50-59 years age group (53.75 %), male (66.75 %). In present study majority were from CKD stage 2 (53.75 %) followed by CKD stage 3 (28.75 %), CKD stage 4

(22.5 %) & CKD stage 5 (13.75 %). Among study patients, 45 patients (56.25 %) had normal LVFP, while 27 patients (33.75 %) had 9-13 LVFP & increase in LVFP (> 13) was noted in 8 patients (10 %). Mean value of LVFP in CKD stage 2 was 8.68 ± 2.15, mean LVFP in CKD stage 3 was 10.34 ± 2.64, mean LVFP in CKD stage 4 was 12.92 ± 3.84 & mean LVFP in CKD stage 5 was 13.46 ± 3.23. We noted statistically significant association between increase in stage of CKD with progressive rise in mean LVFP value. Conclusion: The increase in left ventricular filling pressure is directly proportional to the CKD stage i.e., severity of renal failure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2022,

title = {A study of correlation between uric acid and ejection fraction in heart failure},

author = {Mohammed Mudassir Ali and Mohammed Asif Muzaffer Iqubal and Muhammad Jawed Ali},

url = {https://www.healthcare-bulletin.co.uk/article?title=A+Study+of+Correlation+between+Uric+Acid+and+Ejection+Fraction+in+Heart+Failure_213},

issn = {2042-4884},

year  = {2022},

date = {2022-12-19},

journal = {European Journal of Cardiovascular Medicine},

volume = {12},

issue = {4},

pages = {85-91},

abstract = {Introduction: Chronic heart failure (CHF) is a leading etiology for both morbidity and mortality on a global level, resulting in an increase in both prevalence and health care costs. Recently, our understanding has changed from a mere hemodynamic condition to a much more complicated approach, including neuroendocrine and immune activation. Uric acid (UA) is the end product of purine breakdown and is excreted by the kidneys. Xanthine oxidase and xanthine

dehydrogenase are two enzymes responsible for uric acid breakdown and production. Both enzymes catalyze the oxidation of hypoxanthine to xanthine which is the main enzyme in purine metabolism and contribute to the generation of oxygen free radicals which increased oxidative stress. Materials and Methods: This is an observational study conducted at tertiary care Teaching Hospital over a period of 1 year. All patients who are admitted with symptoms and

signs of Heart Failure in the wards like Intensive Care Unit, Acute Medical Care, Intensive Cardiac Care unit, Medical Wards, Cardiac Wards both paid and general rooms were recruited in the study. The sample size was 100 patients after evaluation by clinical and 2D echocardiography findings. Patients with signs and symptoms of Heart Failure and by satisfying inclusion and exclusion criteria were recruited. Results: A total of 100 patients with heart failure and ejection fraction less than 50 who presented to the department of general medicine. 26 male patients had ACS as the precipitating cause of heart failure compared to 29 female patients. In the present study the range of uric acid was observed between 7.1 – 10 mg/dl, the mean uric acid levels were observed to be 8.6 ± 0.67. In the present study, the range of Ejection fraction was observed between 28 – 48%, the mean ejection fraction was observed to be 34.8 ± 6.65. In the present study, it was observed that there was a significant and inverse correlation observed between uric acid levels and ejection fraction r = -0.808 p<0.001. Conclusions: These data suggest that there is a link between heart failure and the level of uric acid, where one can infer that the metabolic derangements that induce an increase in serum uric acid are likely responsible for the increase in morbidity and mortality as a result of hyperuricemia heart failure patients. In addition, in patients newly diagnosed with hyperuricemia, the risk of identifying a lower ejection fraction is higher.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2022b,

title = {Comparative study to evaluate safety and efficacy of metformin versus sitagliptin alone and combination in type 2 diabetes mellitus},

author = {Mohammed Mudassir Ali and Suhail Bin Ahmed and Muhammad Jawed Ali},

url = {https://www.healthcare-bulletin.co.uk/article?title=Comparative+Study+to+Evaluate+Safety+and+Efficacy+of+Metformin+versus+Sitagliptin+Alone+and+Combination+in+Type+2+Diabetes+Mellitus_214},

issn = {2042-4884},

year  = {2022},

date = {2022-12-19},

journal = {European Journal of Cardiovascular Medicine},

volume = {12},

issue = {4},

pages = {93-97},

abstract = {Introduction: Type 2 Diabetes mellitus (Type 2DM) is chronic, lifelong progressive metabolic disease characterized by hyperglycaemia due to absolute or relative insulinopaenia. Monotherapy with Metformin, a biguanide agent acts primarily as an insulin sensitizer. Its primary clinical site of action is in the liver, improving hepatic insulin sensitivity and as a result, decreasing hepatic gluconeogenesis. Sitagliptin is an oral, highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of patients with Type 2 Diabetes Mellitus. Sitagliptin inhibits the enzymatic degradation and inactivation of glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic peptide (GIP) by DPP-4 the major incretins involved in glucose homeostasis, thereby increasing insulin release and lowering glucagon secretion in a glucose dependent manner. Material and Methods: This is an Open label, Randomized, Parallel group, Comparative and Prospective clinical study. Study was conducted in Type 2DM patients attending the outpatient department of Medicine in tertiary care center. Inclusion criteria: Patients of either sex having age group between 30 -60 years, Patients willing to participate and willing to give written informed consent prior to any study-related procedures and to comply with the

requirements of the study protocol. Patients having newly diagnosed Type II DM with prandial blood glucose levels >200 mg/dl and <250 mg/dl. HbAlc in the range of 6.5 to 8.5 % at screening and BMI >27 kg/m2 Results: The mean fasting blood glucose level in Group I at baseline was 150.81±11.61 mg/dl, in Group II was 151.92±10.44 mg/dl and in Group III was 150.53±11.64. The mean fasting blood glucose level in Group I after 3 months was 99.73±9.91 mg/dl, in Group II was 92.72±9.82 mg/dl and in Group III was 85.72±9.82 mg/dl. These was statistically highly significant difference in mean Fasting Blood Glucose level at baseline versus after 3 months in Group I, Group II and Group III (p<0.0001). Group I the mean of HbA1c level was 8.41±1.91% at baseline and 6.99±1.83% after 3rd month. In Group II the mean of HbA1c level was 8.367±1.83% at baseline, 6.65±1.73% after 3rd month. In Group III the mean of HbA1c level was 8.63±1.81% at baseline and 6.44±1.43% after 3rd month. Conclusion: Sitagliptin with Metformin causes efficient glycaemic control with less significant adverse reaction but the gylcaemic control of patients taking Sitagliptin with Metformin was slightly better as compared to patients taking alone. Thus, concluding Sitagliptin with Metformin to be more efficacious than alone. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Raheem_2022,

title = {Dapsone as a detrimental cause of necrotizing fasciitis with severe resistant neutropenia: A case report},

author = {Juwairiah Abdur Raheem and Arshiya Unnisa and Mohammed Asif Muzaffer Iqubal},

url = {https://www.cureus.com/articles/87048-dapsone-as-a-detrimental-cause-of-necrotizing-fasciitis-with-severe-resistant-neutropenia-a-case-report#!/},

doi = {10.7759/cureus.23076},

issn = {2168-8184},

year  = {2022},

date = {2022-03-11},

journal = {Cureus},

volume = {14},

issue = {3},

pages = {e23076},

publisher = {Cureus, Inc.},

abstract = {Dapsone, which is used for treating dermatological conditions, can lead to neutropenia. Especially, resistant neutropenia makes patients vulnerable to invasive infections, indicating a medical emergency. Febrile neutropenia secondary to dapsone intake should be treated promptly before the development of sepsis, which may lead to shock and death. In addition, necrotizing fasciitis is a severe and potentially fatal soft-tissue infection that rarely develops in healthy individuals with skin lesions. In this report, we present a case of a patient with no comorbidities who presented with necrotizing fasciitis and neutropenia with a history of dapsone intake.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2021b,

title = {A study of the cardiovascular risk factor profile in patients with acute coronary syndrome},

author = {Syed Azhar Ali and Mohammed Hidayathulla and Wajhia Sultana and Amina Shareef},

url = {https://www.ijhcr.com/index.php/ijhcr/article/view/876/763},

issn = {2590-3241},

year  = {2021},

date = {2021-02-08},

urldate = {2021-02-08},

journal = {International Journal of Health and Clinical Research},

volume = {4},

issue = {3},

pages = {70-73},

abstract = {ntroduction:Acute coronary syndrome (ACS) remains a leading cause of death in the United States. Numerous studies have shown that the risk factors are  major if not the most important determinant of long-term outcome in ACS.Aims:This study is taken up to study the cardiovascular risk factor profile in patients with acute coronary syndrome.Materials and methods: 120 patients with acute coronary syndrome, admitted to the ICCU,  Department of  Cardiology,  ,who had  been  diagnosed  with  acute coronary  syndrome were enrolled  for  the  study.Results:  In  this  study 60%  of  patients  had  metabolic  syndrome and  40%  did  not  satisfy  the  criteria  for  MS.  In  the  MS+  group  59  (82%)  are  males  and  13(18%)  are females Mean age of the patients of the study is 51.3 years. Mean age of the patients with and without metabolic syndrome is 52.3 and 48.9 years respectively. 22%, 45.8%, 29%, 20.8% and 16.7% of patients with metabolic syndrome had history of  smoking, hypertension, diabetes, obesityand  coronary  artery  disease  respectively,  of  which  history  of  hypertension  has  statistical  significance.Among  males,  34  satisfied3  criteria  of metabolic  syndrome,  17  satisfied 4  criteria  and  2  satisfied all  5 criteria  of  MS.  Among  females, 3  satisfied  3 criteria of  metabolic  syndrome, 7 satisfied 4 criteria and 4 satisfied all 5 criteria.Conclusion:The most commonly affected were elderly. Among the risk factors, smoking was the most common risk factor found in the present study.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ahmed_2021,

title = {Study of carotid intima-media thickness and its association with coronary artery disease and other risk factors},

author = {Suhail Bin Ahmed and Md. Fawad Ali},

url = {https://www.iaimjournal.com/storage/2021/01/iaim_2021_0801_09.pdf},

issn = {2394-0026},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {International Archives of Integrated Medicine},

volume = {8},

issue = {1},

pages = {58-62},

abstract = {Background: The investigation of the cardiovascular diseases requires invasive and non-invasive tools in establishing the diagnosis. This study was mainly undertaken to relate the CIMT with the risk factors of coronary artery diseases. Material and methods: A case control study was undertaken in department of General Medicine in a tertiary care hospital in 30 cases and 60 controls. Intima-media thickness was measured by using B mode scanner as the distance between the leading edge of the first echogenic line of the far wall of the carotid artery (lumen-intima interface) and the leading edge of the second echogenic line (media-adventitia interface). Results: The number of risk factors was higher in cases than controls. The cases demonstrated high CIMT than controls. The CIMT increased with increase in number of risk factors. Conclusion: CIMT can be used as non-invasive tool in assessment of coronary artery diseases. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hidayathulla_2020,

title = {A prospective study of benefits and risk of paclitaxel drug in the treatment of femoropopliteal artery disease},

author = {Mohammed Hidayathulla and Syed Azhar Ali and Syeda Tasneem Kausar},

url = {https://ejmcm.com/uploads/paper/5449bd7638f1d78a6d43ec2420c67ca8.pdf},

issn = {2515-8260},

year  = {2020},

date = {2020-09-30},

urldate = {2020-09-30},

journal = {European Journal of Molecular and Clinical Medicine},

volume = {7},

issue = {9},

pages = {3588-3597},

abstract = {Introduction: Femoro-popliteal arterial disease is a common vascular condition and Various methods of revascularization have been tried which includes simple balloon angioplasty, debulking techniques , stent implantation , and recently the drug eluting balloons. Paclitaxel drug eluting balloons are more promising in the approach to treat femoro-popliteal arterial disease . Material and Methods: The present study from march 2016 to january 2018 was conducted on 25 cases prospectively in patients admitted to the Department of cardiology sri jayadeva institute of cardiovascular sciences and research center, Bangaluru (Karnataka). femoral artery using cross over sheath VascuQol – 6 disease specific health related quality of life questionnaire post procedure . Results: A success rate of 92% was recorded and patients treated with DCB showed significantly higher primary patency of the affected vessel. The current study reveals that vascuQoL-6 score used to assess the quality of life of the patient with peripheral arterial disease before and after the intervention improved and it is statistically significantly. Conclusion: We conclude that Use of paclitaxel drug coating balloon is safe and efficacious in treating femoro-popliteal arterial disease. Restenosis which was noted in 8% of our cases can be successfully managed with percutaneous transluminal angioplasty using same DCB.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lodhi_2019,

title = {Voglibose and its significance in prediabetes: an observational study},

author = {Mohammed Mansoor Ali Khan Lodhi and Anjum Sultana Khatoon},

url = {https://www.medicalsciencejournal.com/assets/archives/2019/vol5issue8/5-8-27-875.pdf},

issn = {2454-9142},

year  = {2019},

date = {2019-06-22},

urldate = {2019-06-22},

journal = {International Journal of Medical and Health Research},

volume = {5},

issue = {8},

pages = {153-154},

abstract = {Aim: to achieve glycemic control in prediabetic patient with Alpha glucosidase inhibitors who are risk of developing frank diabetes mellitus. Material and Methods: In the present study a total of 150 prediabetic patients were selected out of which only 100 participants were eligible for study. Inclusion Criteria: 1) Age: 20-60yrs, 2) FBS: 101-125mg/dl, PPBS: 141 -199mg/dl, 3) BMI: 24-29 4) HbA1c: 5.7-6.4%. Exclusion Criteria: 1) Known Diabetic 2) Any h/o of intake of oral Hypoglycemic Agents 3) Preexisting CAD, Renal Dysfunction, Hepatic Dysfunction, Gastro-intestinal Disorders. Results: 100 eligible patients were enrolled as per Inclusion criteria, they were divided into two groups, Group 1 (n=53) was placed on Diet, lifestyle modification and Voglibose 0.3mg twice a day, whereas the Group B (n=47) was placebo group. The mean duration of treatment was 24·6 weeks (SD 18.4)—i.e.23.6 weeks (17·5) for voglibose and 25·4 weeks (18.9) for placebo. In group A (n=53), there were 23 males (43.39%), and 30 female subjects (56.60%), whereas in the placebo arm (n=47), there were 20 males (42.55%), 27 Female (57.44%). In the analysis, we found that patients on voglibose was better and the glycemic control was within the standard recommended lines than placebo in individuals Conclusion:A systematic approach and close monitoring that increased the adherence to medication, diet, and counselling would help in better glycemic control and prevent long term complication. In patient with prediabetes, early intervention with medication can prevent long term complication and also prevents or delays the onset of frank diabetes mellitus.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lodhi_2019b,

title = {Glycemic control with four way model approach in rural area patients},

author = {Mohammed Mansoor Ali Khan Lodhi},

url = {https://www.msjonline.org/index.php/ijrms/article/view/6040/4580},

doi = {10.18203/2320-6012.ijrms20191298},

issn = {2320-6012},

year  = {2019},

date = {2019-03-27},

urldate = {2019-03-27},

journal = {International Journal of Research in Medical Sciences},

volume = {7},

issue = {4},

pages = {977-981},

abstract = {Background: It is very important to keep the Glucose levels under control continuously and without any holidays. Type 2 diabetes is increasingly common in the industrialized world. Tight glycemic control attempts to rigidly glucose control levels (A1c: 6.5% -7.0% or lower). Maintaining tight glycemic control is lifesaving. Proper counselling, proper nutrition and if regular exercise is done it can result is good glycemic control. Methods: In the present study a total of 350 diabetic patients were selected out of which only 208 participants were eligible for study. Inclusion criteria in the study were 1) Age: men and women between age group 30 years to 70 years and 2) Type 2 Diabetes mellitus with HbA1c between 8 to 10%. Exclusion criteria in the study were 1) Type 1diabetes mellitus, Pre-existing renal, hepatic or cardiac disease, Hba1c >10%. A quadriad was established between patients, personal health worker, dietician and doctor. Results: Participants had regularly followed up and were divided randomly into cases (n = 112) and controls (n = 96). Patient were followed up as per study design it was observed that at the end of 3 months period mean FBS (case group 168.2±26.4 control group 200.8±38.3 p value <0.001) , Mean PPBS (case group 204.8±53.0 control group 271.0±45.5 p value <0.001) and Mean Hba1c (case group 8.7±0.5 control group 8.9±0.6 p value .003) in cases was significantly lower than control group.at the end 6 months it was observed that the mean cholesterol, mean triglyceride, mean LDL and mean VLDL was significantly lower in the cases compared to controls. Conclusions: A systematic approach and close monitoring that increased the adherence to medication, diet, and counselling would help in better glycemic control and prevent long term complication.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khatoon_2017,

title = {Glycemic impact of individual oral hypoglycemic drugs in type 2 diabetes mellitus-an observational study},

author = {Anjum Sultana Khatoon and Mohammed Mansoor Ali Khan Lodhi},

url = {https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_1762_v1.pdf},

issn = {2393-915X},

year  = {2017},

date = {2017-12-08},

urldate = {2017-12-08},

journal = {International Journal of Contemporary Medical Research},

volume = {4},

issue = {11},

pages = {2454-2459},

abstract = {Introduction: The Incidence and prevalence of type 2 diabetes mellitus around the world is dramatically increasing over the past decades. Study aimed to assess the effectiveness of various Oral Hypoglycemic drugs on glycemic levels in established Type 2 Diabetes Mellitus patients. Material and Methods: In the present study 300 diabetic patients were selected and randomized into three groups. Group A comprised 100 patients whose baseline glycemic parameters were recorded and patients received Vildagliptin 50 mg twice a day, whereas Group B comprised of 100 patients and these patients received metformin 0.5gm–2gm/day and Group C comprised of 100 patients and these patients received Voglibose 0.2mg thrice a day for 24 weeks. Patients

were monitored closely for ensuring the compliance to diet, drug and exercise. Result: In the present study patients were randomly divided into three groups, Group A on Vildagliptin 50 mg, Group B on metformin 500mg – 2000mg. Group C on Voglibose 0.2mg. These entire three groups baseline FBS, PLBS, HBa1C was

estimated prior to the study. It was observed that the mean baseline HBA1c in the Group A patients was 7.83 % and in Group B was 7.92%, Group C was 7.94% whereas the mean HbA1c after 24 weeks of therapy was 7.42%, 7.78% and 7.81% respectively in the Group A, B, and C. There was a significant decrease in HBA1c in all these three groups and it was statically significant. Conclusion: In summary, all three Oral hypoglycemic agent

vildagliptin or metformin or voglibose monotherapy helped in improving glycemic control in patients with type 2 diabetes mellitus. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ahmed_2017b,

title = {The association of hyperuricemia with progressive diabetic nephropathy in patients with type II diabetes mellitus},

author = {Suhail Bin Ahmed and Ather Akhtar Pasha and Yogita Singh Thakur},

url = {https://www.iaimjournal.com/storage/2017/11/iaim_2017_0411_37.pdf},

issn = {2394-0026},

year  = {2017},

date = {2017-11-04},

urldate = {2017-11-04},

journal = {International Archives of Integrated Medicine},

volume = {4},

issue = {11},

pages = {269-274},

abstract = {Background: Diabetic nephropathy (DN) is a progressive kidney disease caused by the damage to the capillaries in the kidneys’ glomeruli. Uric acid is the end product of purine catabolism and is excreted in the urine. Uric acid can serve as an inflammatory factor and is attributed to bring about endothelial dysfunction. The causal role of uric acid in the development of diabetic nephropathy is unknown. This study aimed to evaluate the association of serum uric acid level and low levels of estimated glomerular filtration rate (eGFR) which is an indicator of renal disease progression in patients with Type II (T2D) diabetes mellitus. Methods: A cross sectional analytical observational study was conducted on 150 patients with T2D. Since the study was an observational study it involved no medical intervention. Venous blood samples were obtained in fasting state for determination of random blood sugar, serum creatinine, uric acid, (HbA1c) hemoglobin A1c (reference range 3.8-5.5%); and blood urea nitrogen (BUN). Using MDRD formula eGFR was calculated as = 186 x [serum creatinine]-1.154 x [Age] -0.203 x 0.742. The association of renal disease with T2D and the grading of the patients into different stages of renal failure was analysed by eGFR values. Results: Hundred and fifty diagnosed cases of T2D were included in the present study. The mean age of the study population was 63 ± 12.2. No significant age and gender related variation in serum uric acid level was noted in the study population. The prevalence of Hyperuricemia was 19.33%. The mean BMI was significantly higher among hyperuricemic subjects in comparison with normouricemic patients. Hyperuricemia was evident in 75% (n=18) of the subjects with diabetic nephropathy. Stage IV and stage V patients were associated with significantly very high (p < 0.01) uric acid levels. Conclusions: Serum uric acid has a significant positive association with diabetic nephropathy

ultimately resulting in end stage renal disease. Treatment intervention is out of the scope of this study.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ahmed_2017c,

title = { Incidence of sub clinical thyroid dysfunction among asymptomatic adult population},

author = {Suhail Bin Ahmed and Ather Akhtar Pasha and Yogita Singh Thakur},

url = {https://www.iaimjournal.com/storage/2017/11/iaim_2017_0411_36.pdf},

issn = {2394-0026},

year  = {2017},

date = {2017-11-04},

urldate = {2017-11-04},

journal = {International Archives of Integrated Medicine},

volume = {4},

issue = {11},

pages = {264-268},

abstract = {Background: Patients with subclinical thyroid dysfunction are universally encountered in routine clinical practice. Advanced diagnostic techniques have created new categories of thyroid disorders such as subclinical hypo-and-hyperthyroidism. The management of subclinical thyroid dysfunction is controversial. Patients with subclinical thyroid dysfunction may have vague, nonspecific symptoms that do not aid the clinical apperception. This study aimed to screen the normal adult population for the incidence of subclinical thyroid dysfunction and discuss the optimal management strategy. Materials and methods: Four hundred subjects with no clinical evidence of thyroid dysfunction were included in the present study. Elaborate history in the form of a symptom questionnaire was obtained and clinical examination was performed. Laboratory analysis of thyroid function was done by electro-chemiluminescence immunoassay (ECLIA). Patients with normal free thyroxine (FT4) and tri-iodothyronine levels (T3) were further classified into subclinical hypo/hyperthyroid based on the

serum thyroid-stimulating hormone (TSH) levels. The incidence of subclinical thyroid disorder in the sample population was detected and optimal management strategies were followed as per the European thyroid association (ETA) guidelines. Results: The normal TSH value by ECLIA was 0.27 - 4.2μIU/ml. Seventeen (4.25%) out of four hundred subjects included in the present study were found to have subclinical thyroid dysfunction.

The Ratio of subclinical hypothyroid cases to subclinical hyperthyroid cases was found to be 12:5. Clustering of the cases was found around the age of 60 years and was significantly more common among females in comparison to males. Cases with subclinical thyroid dysfunction were managed by follow up after a thorough evaluation and treatment of other comorbid conditions. Conclusions: The study provides valuable insight towards understanding the epidemiology and management of subclinical thyroid disorders in the present scenario. Screening is recommended for a high-risk population since there is good evidence that subclinical thyroid dysfunctions may be associated with progression to overt disease in up to 5% of the population.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ahmedi_2017,

title = { Prospective study on prescribing pattern in type 2 diabetes mellitus patients in a tertiary care hospital},

author = {Urooj Ahmedi and Shaheda Siddiqui and Shafia Baseera and Pramod Kumar Korani Ratnam},

url = {https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_4_november_issue_11/1509439646.pdf},

issn = {2349-8870},

year  = {2017},

date = {2017-10-18},

urldate = {2017-10-18},

journal = {European Journal of Biomedical and Pharmaceutical Sciences},

volume = {4},

issue = {11},

pages = {398-405},

abstract = {The study involves screening the prescription trends in type 2 diabetes mellitus patients with comorbid complications imposed with diabetes. However study was undertaken in the Owaisi Hospital and Research Center, to evaluate prevalence rate of type II diabetes mellitus in males and females & actual appropriateness which deserve clinical attention and choice of prescribing pattern promoting rational use of medications. The study was Simple Prospective observational study which was carried out for a period of two months.150 cases were collected in the study which determines number of OADDS therapy administered for type II DM patients ruling out generic or essential drug prescribing and also patients were counselled regarding the medications and diet to be followed to manage DM. The results were analysed. Maximum number of patients were in the age group of above 60 years (40.66%) and among 150 cases, males constituted 61 (40.66%) and females 89 (59.33%). Out of 150 patients 137 patients (91.33%) patients were found suffering with co morbid concurrent illness hypertension followed by other complications associated like CAD, CKD, Hypothyroid, Asthma, Rheumatoid Arthritis and other comorbidities. Essentially assessment of therapy and management of disease with combination therapies of insulin and different oral anti-diabetic drugs were prescribed for proper glycemic control. As well clinical attention on patient counselling by clinical pharmacist indicates clinical effectiveness of therapy influenced by prescribed agent selection and therapy changes as well patient’s adherence with drug regimens.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kondeti_2017,

title = {Effects of gestational diabetes in pregnancy},

author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam},

url = {https://www.medpulse.in/Article/Volume4Issue10/MedPulse_4_10_4.pdf},

doi = {10.26611/10041014},

issn = {2348-1897},

year  = {2017},

date = {2017-10-16},

urldate = {2017-10-16},

journal = {MedPulse-International Medical Journal},

volume = {4},

issue = {10},

pages = {974-975},

abstract = {Gestational Diabetes Mellitus (GDM) is the most common medical complication and metabolic disorder of pregnancy. Proper recognition and intervention can reduce the well described GDM associated perinatal morbidity and mortality},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kondeti_2017b,

title = {Prevalence of thyroid disorder in pregnancy and pregnancy outcome},

author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam},

url = {https://www.medpulse.in/Article/Volume4Issue10/MedPulse_4_10_2.pdf},

doi = {10.26611/10041012},

issn = {2348-1897},

year  = {2017},

date = {2017-10-07},

urldate = {2017-10-07},

journal = {MedPulse-International Medical Journal},

volume = {4},

issue = {10},

pages = {969-970},

abstract = {Thyroid disorders constitute one of the most common endocrine disorders seen in pregnancy. Maternal thyroid function changes during pregnancy and inadequate adaptation to these changes results in thyroid dysfunction. Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kondeti_2017c,

title = {Effect of maternal anemia on placental and fetal outcome},

author = {Sowmya Sri Kondeti and Pramod Kumar Korani Ratnam},

url = {https://medpulse.in/Article/Volume4Issue10/MedPulse_4_10_1.pdf},

doi = {10.26611/10041011},

issn = {2348-1897},

year  = {2017},

date = {2017-10-02},

urldate = {2017-10-02},

journal = {MedPulse-International Medical Journal},

volume = {4},

issue = {10},

pages = {965-968},

abstract = {Anemia during pregnancy is very common. More than one-quarter of the world's population is anemic. Growth of the fetus is intricately linked with that of placenta, because placenta helps in transfer of nutrients and oxygen from mother to fetus. Placenta is a focus of increasing interest because significant pathology afflicts the placenta, often before affecting the fetus.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Baseera_2017,

title = {A Prospective Study on drug prescribing pattern in hypertensive patients in a tertiary care teaching hospital at Hyderabad},

author = {Shafia Baseera and Shaheda Siddiqui and Urooj Ahmedi and Pramod Kumar Korani Ratnam},

url = {http://www.journalijcar.org/sites/default/files/issue-files/3865-A-2017.pdf},

doi = {10.24327/ijcar.2017.6204.0893},

issn = {2319-6475},

year  = {2017},

date = {2017-09-28},

urldate = {2017-09-28},

journal = {International Journal of Current Advanced Research},

volume = {6},

issue = {9},

pages = {6200-6204},

abstract = {Background: Irrational drug prescribing is a common practice globally; it results in increased morbidity, mortality & economic burden on society. Drug utilisation studies are an important tool to promote rational prescribing. Aims & Objective: To study on drug prescribing pattern in hypertensive patients. Materials and Methods: A drug utilisation study was conducted in hypertensive patients by the department of pharmacology in medicine OPD at OHRC, Hyderabad, Telangana for 2 months. 153 prescriptions were evaluated for prescribing pattern by using WHO drug use indicators. Results: 153 prescriptions were analysed. A total of antihypertensive drugs were prescribed. 60 angiotensin receptor blockers (ARBs), 8 angiotensin converting enzyme (ACE) inhibitors, 43Beta blockers, 43 Calcium channel blockers, 29 Fixed dose combinations (FDCs) of antihypertensives were included. 1.20 drugs were prescribed per prescription. 8 out of the total 15 antihypertensive drugs that were mentioned in the essential drug list 2016-17 were prescribed. Conclusion: Most commonly prescribed drugs were ARBs and ACE inhibitors. Rational prescribing requires consideration of dose to duration and interaction with other medications. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lodhi_2017,

title = {Impact of early addition of teneligliptin to metformin in type 2 diabetic patients},

author = {Mohammed Mansoor Ali Khan Lodhi and Anjum Sultana Khatoon},

url = {https://www.ijcmr.com/uploads/7/7/4/6/77464738/1529_jul_22.pdf},

issn = {2393-915X},

year  = {2017},

date = {2017-07-19},

urldate = {2017-07-19},

journal = {International Journal of Contemporary Medical Research},

volume = {4},

issue = {6},

pages = {2454-2459},

abstract = {Introduction: Diabetes is a noncommunicable disease. Present study assessed the effectiveness of early addition of Cost effective teneligliptin to Metformin in Type 2 Diabetes Mellitus patients. Material and Methods: 100 subjects were enrolled, of which only 28 subjects were eligible for the study. The study group comprised of 28 subjects who were on metformin monotherapy i.e. between 1000gms to 2000gms per day. 500 mg of metformin in the study group was replaced with DPPIV inhibitor- teneligliptin 20mg per day. In order to study the efficacy of combination therapy versus metformin monotherapy Paired t test was performed after completion of 12weeks of therapy. Result: The efficacy of combination therapy was assessed by Paired t test. It was observed that the mean FBS after addition of teneligliptin was (109.36 mg/dl ± 10.92) when compared to

(118.07mg/dl ±12.76) in the Metformin monotherapy (t value:4.98; p value <0.001) there was significant  decrease in Fasting blood glucose level after addition of teneligliptin. The mean PPBS after addition of teneligliptin was (182.61 mg/dl ±33.05) when compared to (203.18mg/dl ±38.04) in the Metformin monotherapy (t value: 7.76; p value <0.001) there was significant decrease in post prandial blood glucose level after addition of teneligliptin. The mean baseline HbA1c after addition of teneligliptin was (7.44% ±0.35) when compared to (7.65% ±0.38) in the Metformin monotherapy (t value: 7.12; p value <0.001) there was significant decrease in HbA1C level after addition of teneligliptin. The incidence of Gastro-intestinal adverse events was more in metformin monotherapy than addition of teneligliptin however it was not statically significant. In addition there was no statically significant change observed with respect to lipid profile, body weight, Insulin Levels and HOMA score. Conclusion: Teneligliptin was selected for the study because it has longer half-life, dual mode of elimination, superadded it is cost effective and cheaper in India than compared to other DPPIV

inhibitors, due to its cheaper cost the compliance was better with respect to usage of teneligliptin. Ultimately Teneligliptin add-on to Metformin during the early course of treatment would be a multimodal approach in treatment of Diabetic patients further it could help in delaying the exhaustion of pancreatic islet function.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Faheem_2017,

title = {Levels of serum magnesium in normal persons and persons suffering from viral hepatitis and diabetes mellitus-a comparative study},

author = {Raisa Faheem and Anjum Sultana Khatoon},

url = {https://www.jebmh.com/articles/levels-of-serum-magnesium-in-normal-persons-and-persons-suffering-from-viral-hepatitis-and-diabetes-mellitus--a-comparat.pdf.pdf},

doi = {10.18410/jebmh/2017/688},

issn = {2349-2562},

year  = {2017},

date = {2017-07-15},

urldate = {2017-07-15},

journal = {Journal of Evidence Based Medicine and Healthcare},

volume = {4},

issue = {57},

pages = {3456-3458},

abstract = {BACKGROUND: The Magnesium is the fourth most abundant cation in the body, second most abundant cation of the intracellular fluid and is known to be intimately associated with a variety of metabolic events. Magnesium is one of the most vital elements in biologic systems. In the plant world, it is the key element of chlorophyll. In the animal world, it is essential for many vital enzyme systems among which is the activation of membrane bound adenosine triphosphates. This enzyme system deals with energy production through oxidative phosphorylation and with distribution of sodium and potassium across the cell membrane. MATERIALS AND METHODS: The patients admitted in Owaisi Hospitals & Research Centre, Hyderabad were clinically investigated and pathological proved have been selected for the present study of serum magnesium estimation. In the present case 22 cases of viral hepatitis and 40 cases of normal (control) were considered and (40 normal individuals, 30 males and 10 females were studied to serve as controls and 15 cases of diabetes mellitus are studied in the present case. RESULTS: The present study presents the data on level of serum Magnesium in normal and diseased persons (Viral Hepatitis). The results reveal that the mean serum magnesium levels are found to be higher in Viral Hepatitis and in diabetes mellitus in Comparison with that of Control (Normal) Group. CONCLUSION: This study has shown that the mean Serum Magnesium Level were higher in cases of Viral Hepatitis and in diabetes mellitus in comparison with the normal control group. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Abubaker_2017,

title = {Teneligliptin in management of diabetic kidney disease: a review of place in therapy},

author = {Mohammed Abubaker and Preetesh Mishra and Onkar C. Swami},

url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2017&volume=11&issue=1&page=OE05&issn=0973-709x&id=9228},

doi = {10.7860/jcdr/2017/25060.9228},

issn = {0973-709X},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {Journal of Clinical and Diagnostic Research},

volume = {11},

issue = {1},

pages = {OE05-OE09},

publisher = {JCDR Research and Publications},

abstract = {Diabetes is a global health emergency of this century. Diabetic nephropathy is the most common microvascular complication associated with Type 2 Diabetes Mellitus (T2DM). T2DM has been reported as a major etiological factor in almost 45% of patients undergoing dialysis due to kidney failure. Lifestyle modifications; cessation of smoking, optimum control of blood glucose, blood pressure and lipids are required to reduce the progression of Diabetic Kidney Disease (DKD). Presently, Dipeptidyl peptidase-4 (DPP-4) inhibitors are preferred in the management of T2DM due to their established efficacy; favorable tolerability including, low risk of hypoglycaemia; weight neutrality and convenient once-a-day dosage. Present evidence suggests that linagliptin and teneligliptin can be used safely without dose adjustments in patients with T2DM with renal impairment, including End Stage Renal Disease (ESRD). There is a limited data about teneligliptin particularly in T2DM patients with renal impairment. The objective of this review is to evaluate efficacy and safety of teneligliptin in T2DM patients with renal impairment, in order to assess the current place in therapy and future prospects of teneligliptin. Reported evidence suggests that teneligliptin has consistent pharmacokinetic in mild, moderate, severe or ESRD, without any need for dose adjustments. Limited data from small sample studies of teneligliptin in DKD patients reported significant improvements in glycaemic parameters. Additionally, there is an improvement in kidney parameters like glycated albumin, urinary albumin and eGFR. There is an evidence of reduction in biomarkers of kidney impairment like P-selectin (sP-selectin), Platelet-Derived Microparticles (PDMPs) and Plasminogen Activator Inhibitor 1 (PAI-1). Clinical significance of these will be known in near future. Thus, teneligliptin has an important place of therapy in the management of T2DM with renal impairment.},

key = {pmid28273997},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2016b,

title = {A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism},

author = {Mayana Kaleemullah Khan and Mohammed Nasir Mohiuddin},

url = {https://www.msjonline.org/index.php/ijrms/article/view/152/181},

doi = {10.18203/2320-6012.ijrms20162911},

issn = {2320-6012},

year  = {2016},

date = {2016-12-18},

urldate = {2016-12-18},

journal = {International Journal of Research in Medical Sciences},

volume = {4},

issue = {9},

pages = {3934-3938},

abstract = {Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients. Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females. Results: In present study 25 cases of age group 41-65 years  there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia. Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khatoon_2016b,

title = {Effect of proteinuria in diabetes mellitus},

author = {Anjum Sultana Khatoon and Raisa Faheem},

url = {https://www.jebmh.com/abstract/effect-of-proteinuria-in-diabetes-mellitus-82118.html},

issn = {2349-2562},

year  = {2016},

date = {2016-12-08},

urldate = {2016-12-08},

journal = {Journal of Evidence Based Medicine and Healthcare},

volume = {3},

issue = {98},

pages = {5404-5412},

abstract = {BACKGROUND: Diabetic nephropathy is a dreaded complication of type 2 diabetes mellitus. However, in the early stages, also known as incipient nephropathy, it can be detected by presence of proteinuria. The aim of our study is to know the occurrence of proteinuria in patients with type 2 diabetes mellitus and to note its associations with the duration of diabetes since diagnosis and also the various macrovascular and microvascular complications of diabetes mellitus. MATERIALS AND METHODS: This study was undertaken in Princess Esra Hospital/DCMS - Hyderabad. A total of one hundred randomly selected diabetic patients satisfying the inclusion criteria were selected for the study. All patients were evaluated in detail along with the testing for proteinuria with dipsticks (Micral). RESULTS: The overall occurrence of proteinuria was 38%. The occurrence of proteinuria showed a direct relationship with increasing age (p=0.053) and increasing duration of diabetes since diagnosis. An HbA1c value above 7% is associated with 50% or higher incidence of proteinuria (p=0.018). Patients with a body mass index of more than 25 kg/m2 have significant increase in the incidence of proteinuria (p=0.027). The incidence of proteinuria is significantly associated with the presence of retinopathy (p=0.073), peripheral neuropathy (p=0.009), ischaemic heart disease (p=0.011) and hypertension (p=0.001). Proteinuria is inversely associated with HDL (p=0.089). CONCLUSION: The occurrence of proteinuria in type 2 diabetic patients of Hyderabad was quite high. During the evaluation of diabetic patients, the possibility of proteinuria and its correlation with various complications of diabetes mellitus should be kept in mind.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2016,

title = {A study on estimation of serum calcium in subclinical hypothyroid females of different age groups and its correlation with thyroid stimulating hormone (TSH)},

author = {Mayana Kaleemullah Khan and Mohammed Nasir Mohiuddin and Nooruddin Owaisi},

url = {https://www.jebmh.com/articles/a-study-on-estimation-of-serum-calcium-in-subclinical-hypothyroid-females-of-different-age-groups-and-its-correlation-wi.pdf.pdf},

doi = {10.18410/jebmh/2016/820},

issn = {2349-2562},

year  = {2016},

date = {2016-09-30},

urldate = {2016-09-30},

journal = {Journal of Evidence Based Medicine and Healthcare},

volume = {3},

issue = {71},

pages = {3836-3839},

abstract = {BACKGROUND: Hypothyroidism is a clinical condition arising because of the inadequacy of thyroid hormones or from inability to perform a normal function. Hypothyroidism is a typical metabolic condition in almost all community groups. In India, 42 million individuals are experiencing thyroid disease; hypothyroidism being the commonest thyroid disorder.(1) Serum calcium levels are lower in patients with high TSH than with typical TSH (p <0.01). METHODOLOGY: There were 50 females with SCH were selected in the study. Patients with 18 to 65 years of age, with TSH levels more than 5.0 mIU/L, free T4 within normal limits, and general well-being patients were incorporated. The study period was from January to April 2016. Owaisi Hospital and Research Centre, it is a 1000 bedded hospital with super specialty services in Hyderabad, giving particularly tertiary level human services to all strata of individuals. RESULTS: Out of 50 patients, 24 patients with hypothyroidism are in hypocalcaemia, which constitute 48% (n=24) of the people required in the study had estimation of serum calcium under 9 mg/dL. This shows to be the one of the important concern associated with hypothyroidism. In rest 52% (n=26) of patients who were having normal calcium levels, chances of developing hypocalcaemia in future is high. DISCUSSION: The mean age, serum calcium and thyroid stimulating hormone (TSH) in AlaEldin S. Ashmaik et al was: Age: 32.00±15.76, TSH: 26.02±34.74, and serum calcium: 7.97±.62 while in our study it shows a mean age of 39.9 ±13.82, TSH: 10.47 ±3.46, and serum calcium: 9.04 ±1.47. The mean age in our study was higher than the study by AlaEldin done in Sudan population, the mean TSH was found to be much lower while the serum calcium levels show elevated levels in our study in contrast to study by AlaEldin S. Ashmaik et al. CONCLUSION: This study presumed that in Telangana state, patients have low levels of serum calcium in hypothyroidism. S.Ca++ in hypothyroid people demonstrates a constructive connection between the S.Ca++ and serum TSH. These fluctuations of serum calcium ought to be considered in treating the patients with hypothyroidism by therapeutic experts. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Raheem_2016,

title = {Comparative analysis of serum malondialdehyde levels as a marker of oxidation stress in acute myocardial infarction cases with and without T2DM},

author = {M. A. Raheem and Mohammed Siraj and Rajashekar Reddy Gurrala and Syed Azhar Ali and Priyanka T. N. and Mohammed Ishaq},

url = {https://www.journalijar.com/uploads/460_IJAR-10867.pdf},

issn = {2320-5407},

year  = {2016},

date = {2016-06-30},

urldate = {2016-06-30},

journal = {International Journal of Advanced Research},

volume = {4},

issue = {6},

pages = {1270-1272},

abstract = {Oxidative stress is considered as one of the important mechanism in the causation of type 2 diabetes (T2DM) as well as cardiovascular diseases. Quantification of serum malondialdehyde (MDA) is generally employed as

reliable marker of assessment of oxidative stress. The objective of the present study was to estimate serum MDA levels in acute myocardial infarction cases with and without T2DM. A total of 60 AMI patients were studied, including 30 cases of AMI with T2DM and an equal number of cases of AMI without T2DM. Mean serum levels of MDA were 543.17± 56.97 and 423.50 ± 51.12 nmol/dL respectively in cases of AMI with T2DM and those without T2DM (p<0.05). Significantly elevated levels of serum MDA were observed in T2DM cases with AMI than those without T2DM. Significance of the results has been discussed in terms of age at onset as well as severity of AMI. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pasha_2016b,

title = {Magnesium supplementation: is this a miracle drug to control diabetes-induced abnormal lipid profile},

author = {Ather Akhtar Pasha and Suhail Bin Ahmed},

url = {https://www.jebmh.com/articles/magnesium-supplementation-is-this-a-miracle-drug-to-control-diabetesinduced-abnormal-lipid-profile.pdf.pdf},

doi = {10.18410/jebmh/2016/376},

issn = {2349-2562},

year  = {2016},

date = {2016-04-30},

urldate = {2016-04-30},

journal = {Journal of Evidence Based Medicine and Healthcare},

volume = {3},

issue = {35},

pages = {1679-1682},

abstract = {BACKGROUND: Reduced levels of magnesium levels have been observed in adults who have diabetes mellitus. It was also observed in children who were supposed to have good nutritional status but were diagnosed diabetic. Low levels of serum magnesium have been linked to a number of complications that is observed in diabetes mellitus. Reduced tyrosine kinase activity has been observed. This may result in reduced insulin sensitivity. The low levels of serum magnesium may be due to glycosuria-related hypermagnesiuria, nutritional factors or hyperinsulinaemia. Diabetic patients often have disturabances of their lipid profile. Magnesium supplementation is known to have a benificial effect on the lipid profile. The aim of the study is to find whether magnesium supplementation improves the lipid profile of the diabetic patients or not. METHOD: The study is a cross-sectional study and the study is multi-staged. The age criteria was not taken into consideration since all the patients belonged to the age group of 40 to 60 years. Inclusion Criteria: 1. The patients were atleast known diabetics since one year. 2. Patients were aged between 40 to 60 years. 3. Patients who were ready to be a part of this study and would come back for followup. Exclusion Criteria: 1. Patients who were known to have diabetic renal complications. 2. Patients who were on dialysis. 3. Patients who were on diuretics. 4. Patients who took magnesium antacids. RESULT: The principle finding of this study is that the serum magnesium level is inversely related to the HbA1c, serum cholesterol, LDL and triglycerides. It is directly proportional to the HDL levels. Magnesium is known to play an important role in carbohydrate metabolism, and its imbalance has been implicated in diabetes mellitus both as a cause and a consequence. CONCLUSION: There is a lot of scope for this study since it is slowly being understood that diabetes is not a single disease but a plethora of diseases whose dimensions are slowly being uprooted. Indeed magnesium supplementation improved the lipid profile and in the coming days it would be called a miracle drug with vast potentials. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pasha_2016,

title = {Clinical profile of anaemia in a tertiary care hospital},

author = {Ather Akhtar Pasha and Suhail Bin Ahmed},

url = {https://www.jebmh.com/articles/clinical-profile-of-anaemia-in-a-tertiary-care-hospital.pdf.pdf},

doi = {10.18410/jebmh/2016/356},

issn = {2349-2562},

year  = {2016},

date = {2016-04-25},

urldate = {2016-04-25},

journal = {Journal of Evidence Based Medicine and Healthcare},

volume = {3},

issue = {33},

pages = {1586-1589},

abstract = {BACKGROUND: Anaemia causes a reduction in the oxygen carrying capacity of the blood resulting in tissue hypoxia. Cardiac output at rest is not usually increased in most chronic anaemia until haemoglobin levels fall below 7 g/dL, but abnormal rise in output with exercise may occur with levels as high as 10 g/dL. The increase in cardiac output has been observed to correlate well with the degree of anaemia. Other compensatory mechanisms to chronic anaemia available to the body include decreased circulation time and increased tissue oxygen uptake. The latter is facilitated by a shift to the right of the oxygen haemoglobin dissociation curve. Cardiomegaly may also be as a result of the increased workload on the heart from the increased viscosity of blood in anaemia patients. Anaemia in the elderly is an extremely common problem that is associated with increased mortality and poorer health-related quality of life, regardless of the underlying cause of the low haemoglobin. A study of anaemia in elderly patients found a wide variation in prevalence, ranging from 2.9% to 61% in men and 3.3% to 41% in women. Higher rates were found in hospitalised patients than in community dwellers. It is easy to overlook anaemia in the elderly, since such symptoms as fatigue, weakness, or shortness of breath may be attributed to the ageing process itself. Our objective is to show the prevalence of anaemia even in a tertiary health care centre. METHODS: One hundred patients were identified who were admitted in the Department of Medicine, Deccan College of Medical Sciences. Among the 100 patients, 38 were male and 62 were female. The study was conducted from Jan 2014 To Jan 2015. Patients having haemoglobin less than 10 g% in the medical wards were enrolled in the study. RESULTS: Among the 100 patients, 38 were male and 62 were female. The average haemoglobin was 6.4 g%, the lowest being 2.8 g%. Peripheral blood smear showed hypochromic picture in 58, macrocytic picture in 22 and the morphology was normocytic normochromic in 20 cases. Tuberculosis leading to anaemia was seen in 24, Internal haemorrhoids/Fissures 5, Taenia infestation in 3, Haematological Malignancies 2, GI Malignancies 3, Connective tissues disorders 3, Nutritional iron deficiency 8 and Anaemia of chronic diseases in remaining cases. Among the 22 cases having macrocytic anaemia, 11 had vitamin B 12 deficiency, 6 had subclinical hypothyroidism, 5 had alcoholism. Among the 20 patients having normocytic normochromic blood picture, 4 had haemolytic anaemia, 1 had aplastic anaemia and remaining were having anaemia of chronic disease mainly chronic kidney disease. Regarding treatment, 23 patients were transfused blood. Out of total 100 patients included in the study, in-hospital mortality was 10. CONCLUSIONS: Anaemia is associated with a variety of diseases. As Tuberculosis and B 12 Deficiency are among the leading causes of anaemia, hypochromic and microcytic picture was the predominant picture in peripheral blood smear. Among the patients having normocytic normochromic blood picture, majority were having chronic kidney disease which may be due to the fact that our hospital is a tertiary referral centre for chronic renal failure. In-hospital mortality due to anaemia alone is lower in tertiary care centres, but the mortality in our study is due to associated comorbid conditions like chronic renal failure and malignancy. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hassan_2015,

title = {A case report on Fahr disease},

author = {Syed Najmul Hassan and Anjum Sultana Khatoon},

url = {https://www.cibtech.org/J-Medical-Case-Reports/PUBLICATIONS/2015/Vol-4-No-3/13-JCR-013-ANJUM-DISEASE.pdf},

issn = {2319-3832},

year  = {2015},

date = {2015-09-01},

urldate = {2015-09-01},

journal = {Indian Journal of Medical Case Reports},

volume = {4},

issue = {3},

pages = {46-48},

abstract = {Fahr disease is also known as Idiopathic Basal Ganglia Calcification is a rare, genetically, dominant neurological disorder. This disease is characterized by abnormal deposits of calcium in areas of the brain that control the movement. The present study shows different CT Scans through which different calcifications are seen and analyzed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Qaiyum_2015b,

title = {A study on outcome of nasal septal surgery},

author = {Hamid Abdul Qaiyum and Mohammed Naseeruddin Mujahid and Mayana Kaleemullah Khan and Parveen Naimath and Mohammed Ishaq},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/a-study-on-outcome-of-nasal-septal-surgery/Njg5MA==/?is=1&b1=&k=},

doi = {10.36106/ijar},

issn = {2249-555X},

year  = {2015},

date = {2015-06-01},

urldate = {2015-06-01},

journal = {Indian Journal of Applied Research},

volume = {5},

issue = {6},

pages = {832-835},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pasha_2014,

title = {Acute retention of urine a rare presentation of type 2 diabetes mellitus (DM): a case report},

author = {Ather Akhtar Pasha and Suhail Bin Ahmed},

url = {http://www.ijpmbs.com/uploadfile/2015/0412/20150412044114144.pdf},

issn = {2278-5221},

year  = {2014},

date = {2014-07-01},

urldate = {2014-07-01},

journal = {International Journal of Pharma Medicine and Biological Sciences},

volume = {3},

issue = {3},

pages = {80-83},

abstract = {Abstract—Diabetes Mellitus is causing a big socioeconomic burden in developing countries. Inadequate education and awareness about disease and its complication has further added to existing scenario particularly in India. Common clinical features of Diabetes Mellitus include polyuria, polydipsia and weight loss, nonhealing skin infection. Here we report an unusual case of Diabetes Mellitus presenting as acute retention of urine due to prostatic abscess, which completely recovered with conservative treatment, highlighting complete evaluation, early diagnosis, treatment and prevention of complications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Pasha_2014b,

title = {Role of low dose hydrocortisone in the management of viral thrombocytopenia},

author = {Ather Akhtar Pasha and Suhail Bin Ahmed},

url = {http://www.ijpmbs.com/uploadfile/2015/0412/20150412043958821.pdf},

issn = {2278-5221},

year  = {2014},

date = {2014-07-01},

urldate = {2014-07-01},

journal = {International Journal of Pharma Medicine and Biological Sciences},

volume = {3},

issue = {3},

pages = {95-97},

abstract = {Thrombocytopenia is very common presentation of acute febrile illness. Mostly they are viral in etiology like dengue fever. The white blood cells respond by producing a number of signaling proteins, such as cytokines and interferon's, which are responsible for many of the symptoms, such as the fever, the flu-like symptoms and the severe pains. In severe infection, the virus production inside the body is greatly increased, and many more organs (such as the liver and the bone marrow) can be affected. Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to capillary permeability. As a result, less blood circulates in

the blood vessels, and the blood pressure becomes so low that it cannot supply sufficient blood to vital organs. Furthermore, dysfunction of the bone marrow due to infection of the stromal cells and peripheral destruction of platelets in spleen leads to reduced numbers of platelets, which are necessary for effective blood clotting; this increases the risk of bleeding, the other major complication of dengue fever. The use of low dose corticosteroids helps in stopping the ongoing immune destruction of platelets and hence avoiding platelet transfusion and its associated complications and overall its cost effectiveness in the management of viral thrombocytopenia in Indian scenario.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Anees_2014,

title = {Evaluation of oxidative stress and antioxidant status in relation to glycemic control in Type 1 and Type 2 diabetes mellitus},

author = {Syyeda Anees and Parveen Naimath and Mohammed Siraj and Mohammed Ishaq},

url = {https://docsdrive.com/pdfs/academicjournals/ajbmb/2014/93-98.pdf},

doi = {10.3923/ajbmb.2014.93.98},

issn = {2150-4210},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {American Journal of Biochemistry and Molecular Biology},

volume = {4},

issue = {2},

pages = {93-98},

abstract = {Oxidative stress and antioxidant status was evaluated in relation to glycemic control in Type 1 and 2 Diabetes Mellitus patients (DM). A total of 69 DM patients (34 T1 and 35 T2DM cases) were enrolled in the study along with 15 healthy subjects. The patients were grouped into those with good glycemic control and others with poor glycemic control. Serum fructosamine levels were also determined as a supportive parameter for confirming glycemic status. Serum Malondialdehyde (MDA) level was used as a marker of oxidative stress and serum catalase activity was quantitated for an assessment of anti-oxidant status of the patients. Mean MDA levels in poor glycemic control group of T1 and T2DM were significantly higher (p<0.01) not only than the means of the healthy controls but also than the means of diabeteic groups with good glycemic control (p<0.01). Mean serum catalase activity was significantly reduced in DM patients of all the groups compared to that of healthy controls (p<0.05) indicating considerable reduction in the anti-oxidant status of the patients. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}