@article{Ali_2025,

title = {An overview of quorum sensing in Mycobacterium tuberculosis, tuberculosis and diabetes mellitus},

author = {Shireen Adeeb Mujtaba Ali},

url = {https://journals.lww.com/revmedmicrobiol/abstract/9900/an_overview_of_quorum_sensing_in_mycobacterium.126.aspx},

doi = {10.1097/mrm.0000000000000441},

issn = {2770-3169},

year  = {2025},

date = {2025-06-23},

urldate = {2025-06-01},

journal = {Reviews and Research in Medical Microbiology},

volume = {XX},

issue = {XX},

pages = {XX-XX},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {Every 15 s, a person worldwide dies due to tuberculosis (TB), a disease brought on by Mycobacterium tuberculosis (M. tb). One of the basic mechanisms by which bacteria impose collective behaviors is cell-to-cell communication called Quorum sensing mechanism (QSM). Patients with cystic fibrosis have frequently had sputum samples containing a wide genetic variety of mycobacteria. Due to minute modifications in their morphology, distributive conjugal transfer (DCT), and gene expression level, heterogenic mycobacterial populations are seen to arise. India became a focal point of the global tuberculosis (TB) crisis. The nation, which in 2020 reported the greatest number of projected incident cases of tuberculosis (1.5 million among a total predicted 5.8 million worldwide cases), has set an aggressive goal to eradicate tuberculosis by 2025, as opposed to the traditional deadline of 2030. According to estimates, India will have the second-highest number of diabetes cases worldwide in 2021 (74 million out of an anticipated 537 million cases). It has been highlighted that diabetes treatment, a significant comorbidity among TB patients, should be handled in tandem with TB treatment since early detection is likely to save patient expenditures. In the present review article, authors have given an overview on Quorum sensing in M. tb, Quorum sensing mechanism in M. tb and correlation between TB and diabetes mellitus (DM).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Qureshi_2025b,

title = {Role of forehead flap in covering mid-face defects: a clinical observational study},

author = {Mohd. Rehan Qureshi},

url = {https://healthcare-bulletin.co.uk/article/role-of-forehead-flap-in-covering-mid-face-defects-a-clinical-observational-study-3589/},

doi = {10.5083/ejcm/25-06-45},

issn = {2042-4884},

year  = {2025},

date = {2025-06-15},

urldate = {2025-06-15},

journal = {European Journal of Cardiovascular Medicine},

volume = {15},

issue = {6},

pages = {235-242},

abstract = {Introduction: Mid-face defects resulting from trauma, tumor excision, or infection pose a significant reconstructive challenge due to the complex anatomical and aesthetic considerations involved. The forehead flap remains a cornerstone in facial reconstruction due to its robust vascularity and tissue characteristics. Objectives: To evaluate the effectiveness and outcomes of the forehead flap technique in reconstructing mid-face defects. Methods: A prospective observational study was conducted on 25 patients with mid-face defects treated using forehead flap reconstruction at Deccan College of Medical Sciences, Princess Esra Hospital, between May 2022 and May 2025. Clinical evaluation, aesthetic outcomes, patient satisfaction, and complication rates were assessed. Results: Infection (8%), trauma (24%), and oncologic resections (68%), accounted for the majority of errors. Eighty percent of patients had excellent cosmetic results, with just two cases of flap congestion and one case of wound dehiscence. There was no flap loss noted. Eighty-eight percent of patients were satisfied. Conclusion: The forehead flap is a reliable and aesthetically favorable option for reconstructing mid-face defects, with a high rate of patient satisfaction and low complication rates.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Maryam_2025,

title = {Emerging role of weight-loss medications in the management of heart failure: Current evidence and future perspectives},

author = {Maryam and Treesa P. Varghese and Bachi Tazneem and Gurrala Rajshekhar Reddy},

url = {https://link.springer.com/article/10.1007/s40256-025-00735-y},

doi = {10.1007/s40256-025-00735-y},

issn = {1179-187X},

year  = {2025},

date = {2025-05-28},

urldate = {2025-05-01},

journal = {American Journal of Cardiovascular Drugs},

volume = {XX},

issue = {XX},

pages = {XX-XX},

publisher = {Springer Science and Business Media LLC},

abstract = {Heart failure is a major global health concern as it contributes to high rates of mortality and morbidity, with high rates of hospitalizations. The most prevalent risk factor or comorbidity of heart failure is obesity, which not only worsens and exacerbates disease progression and the course of illness, it also reduces its prognosis. Weight management is still not well addressed, even with major advancements in heart failure pharmacotherapies. Recent advances in weight-loss medications such as glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and other novel anti-obesity drugs have sparked interest in their potential to improve clinical outcomes for patients with heart failure, especially those who also have obesity-related cardiac dysfunction. Weight-loss medications benefit heart failure by reducing adiposity-related inflammation, myocardial stress, and remodeling. These effects are auspicious in heart failure with preserved ejection fraction, where obesity-driven mechanisms play a critical role. These medications have been demonstrated to help with weight reduction, improve heart failure symptoms, and reduce hospitalization rates. However, questions about their long-term safety, particularly in patients with severe heart failure, are still being researched. The purpose of this review is to summarize the current evidence on the safety and effectiveness of weight-loss medications in the treatment of heart failure, describe their mechanisms of action, and highlight knowledge gaps that require further research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hassan_2025,

title = {A clinical study on post-operative pain management},

author = {Khaja Ali Hassan and Syed Asrar Hussain and Mohammed Ahsan Ullah Siddiqui

},

url = {https://jccpractice.com/article/a-clinical-study-on-post-operative-pain-management-663/},

doi = {10.61336/jccp/25-05-24},

issn = {2457-7200},

year  = {2025},

date = {2025-05-12},

urldate = {2025-05-12},

journal = {Journal of Contemporary Clinical Practice},

volume = {11},

issue = {5},

pages = {170-176},

abstract = {Background: Effective postoperative pain management is essential for patient recovery and quality of care. Analgesics, especially opioids and non-opioids, are commonly used in clinical practice, yet their efficacy and patterns of use require continual assessment. Objective: This study aimed to evaluate the analgesic regimens employed and their effectiveness in pain control among 100 postoperative patients, analyzing Numeric Rating Scale (NRS) scores over 48 hours. Methods: A prospective observational study was conducted involving 100 patients undergoing elective and emergency surgeries. Data on demographics, type of surgery, analgesics administered, and NRS scores at 6, 12, 24, and 48 hours postoperatively were collected and analyzed. Results: Tramadol and paracetamol were universally used, with 90% of patients receiving additional non-opioids. Mean NRS scores showed a significant decline from 7.91 at 6 hours to 5.08 at 48 hours, indicating effective pain management over time. Conclusion: Opioid and non-opioid analgesic combinations were effective in reducing postoperative pain. Further studies are recommended to explore multimodal pain management strategies tailored to surgical types and patient profiles.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Qureshi_2025,

title = {Role of locoregional flap in fingertip injury},

author = {Mohd. Rehan Qureshi},

url = {https://healthcare-bulletin.co.uk/article/role-of-locoregional-flap-in-fingertip-injury-3590/},

doi = {10.5083/ejcm/25-05-169},

issn = {2042-4884},

year  = {2025},

date = {2025-05-10},

urldate = {2025-05-10},

journal = {European Journal of Cardiovascular Medicine},

volume = {15},

issue = {5},

pages = {881-889},

abstract = {Introduction: Fingertip injuries are among the most common hand traumas and can significantly impact hand function and quality of life. Proper reconstruction is essential for preserving tactile sensation and aesthetics. Locoregional flaps are frequently employed in fingertip reconstruction due to their simplicity and effectiveness. Objective: To evaluate the functional and aesthetic outcomes of locoregional flaps in the management of fingertip injuries. Methods: This prospective observational study was conducted over a period of three years, from May 2022 to May 2025, at the Department of Plastic Surgery, Deccan College of Medical Sciences, Princess Esra Hospital. A total of 40 patients with fingertip injuries requiring flap coverage were included. Depending on the type and location of the injury, several locoregional flaps were utilised, including V-Y advancement flaps, thenar flaps, and cross-finger flaps. In order to evaluate flap viability, wound healing, function recovery, and cosmetic results, patients were monitored. Results: Most patients demonstrated good functional recovery with minimal complications. Flap survival rate was high, and the majority of patients reported satisfactory aesthetic results. Early intervention and appropriate flap selection were key factors contributing to successful outcomes. Conclusion: In order to effectively treat injuries to the fingertip, locoregional flaps are essential because they provide dependable covering with positive functional and aesthetic outcomes. In reconstructive hand surgery, this method is still useful and practical.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Goud_2025,

title = {Single-staged repair for penoscrotal hypospadias with tunica vaginalis flap},

author = {P. Umesh Chandran Goud and Loya Bharadwaj and Shireen Adeeb Mujtaba Ali and Mohammad Ikramuddin and Mohammed Khaja Arifuddin},

url = {https://journals.lww.com/sbvj/fulltext/2025/04000/single_staged_repair_for_penoscrotal_hypospadias.9.aspx},

doi = {10.4103/sbvj.sbvj_15_25},

issn = {2581-6039},

year  = {2025},

date = {2025-04-30},

urldate = {2025-04-01},

journal = {SBV Journal of Basic, Clinical and Applied Health Science},

volume = {8},

issue = {2},

pages = {75–77},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {Surgery at an early age is recommended for one of the most prevalent congenital genital defects, hypospadias. It is gradually evolving, frequently by repurposing decades-old therapeutic approaches. Preputial onlay flaps were most frequently utilized in the 1980s, although there is currently a resurgence of interest in the tunica vaginalis flap. In a selected number of patients with severe anomalies, hypospadias is surgically repaired in one stage. The process includes creating a neourethra and correcting the curvature of the penile shaft. For optimal functional and cosmetic outcomes, this neourethra requires an intermediate layer to be covered. The tunica vaginalis flap is one of the better choices for usage as an intermediate layer among the several local flaps.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025b,

title = {Airway management in a case of rhinophyma excision},

author = {Naseeba Fatima and Syed Atif Ullah Hussaini and Umesh Jayshree and Shireen Adeeb Mujtaba Ali},

url = {https://journals.lww.com/sbvj/fulltext/2025/04000/airway_management_in_a_case_of_rhinophyma_excision.11.aspx},

doi = {10.4103/sbvj.sbvj_14_25},

issn = {2581-6039},

year  = {2025},

date = {2025-04-30},

urldate = {2025-04-01},

journal = {SBV Journal of Basic, Clinical and Applied Health Science},

volume = {8},

issue = {2},

pages = {81–83},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

abstract = {Rhinophyma is a progressive enlargement of the nose caused by sebaceous gland proliferation. In this case, the condition was neglected until it obstructed the patient’s vision, necessitating surgical excision with grafting. The extensive nasal enlargement posed significant challenges for airway management, particularly in bag-mask ventilation and tracheal intubation. Given the anticipated difficulty, awake tracheal intubation was planned using airway nerve blocks and topical anesthesia. The use of regional anesthesia techniques minimized the risk of hypoxia and ensured patient comfort during the procedure. This case highlights the importance of meticulous airway planning and the role of nerve blocks in managing difficult airways in patients with extensive rhinophyma. Our report emphasizes the efficacy and safety of regional airway anesthesia as a valuable approach in challenging intubation scenarios.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Prevalence of hypertension and associated risk factors in urban and rural populations - A cross-sectional study},

author = {Parvaiz Kadloor and Siddhartha Rout and Sayed Mohmmed Hussain Bangi},

url = {https://healthcare-bulletin.co.uk/article/prevalence-of-hypertension-and-associated-risk-factors-in-urban-and-rural-populations-a-cross-sectional-study-3191/},

issn = {2042-4884},

year  = {2025},

date = {2025-04-19},

journal = {European Journal of Cardiovascular Medicine},

volume = {15},

issue = {4},

pages = {649-653},

abstract = {Introduction: Hypertension is a major public health issue globally, with varying prevalence across different demographics and geographical locations. This study aims to assess the prevalence and associated risk factors for hypertension in urban and rural populations to identify targeted interventions.

Methods: This cross-sectional study involved 500 participants, equally divided between urban and rural settings. Data were collected through health surveys and physical examinations, focusing on hypertension status, demographic variables, lifestyle factors, and access to healthcare services. Statistical analysis included chi-square tests, t-tests, and logistic regression.

Results: The prevalence of hypertension was significantly higher in rural areas (40.8%) compared to urban areas (34.8%) (p=0.045). Rural participants were older and had higher mean body mass index. Factors such as smoking and family history of hypertension were more prevalent in rural populations. Urban residents reported better healthcare access and higher engagement in health awareness programs. Lifestyle factors such as dietary salt intake and physical activity also differed significantly between the two groups.

Conclusion: Hypertension prevalence is significantly influenced by geographic location, with rural populations exhibiting higher rates and associated risk factors. Differences in lifestyle behaviors and healthcare accessibility suggest the need for region-specific health policies and programs to manage and prevent hypertension effectively.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Asimuddin_2025,

title = {Assessment of quality of life and functional status of breast cancer survivors at a tertiary cancer centre},

author = {Mohd. Asimuddin and Sai Teja Adepu and Nagasai Divya Kari and M. Ramakrishna and Kanugula Sravanthi},

url = {https://jccpractice.com/article/assessment-of-quality-of-life-and-functional-status-of-breast-cancer-survivors-at-a-tertiary-cancer-centre-541/},

doi = {10.61336/jccp/25-042},

issn = {2457-7200},

year  = {2025},

date = {2025-04-13},

urldate = {2025-04-13},

journal = {Journal of Contemporary Clinical Practice},

volume = {11},

issue = {4},

pages = {257-271},

abstract = {Background: With improved screening and treatment modalities, the survival rate of breast cancer patients has significantly increased. However, survivorship brings its own challenges, including physical, psychological, and social sequelae that affect the quality of life (QoL) and functional status of survivors. Aim: To assess the quality of life and functional status in breast cancer survivors. Methods: A cross-sectional study was conducted among breast cancer survivors attending the oncology outpatient department of a tertiary cancer care center. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and its breast cancer-specific module (QLQ-BR23) were administered to evaluate QoL and functional outcomes. Sociodemographic and clinical data were also collected. Descriptive statistics and inferential analyses (chi-square, t-test) were used to determine significant associations. Results: Among the survivors (N = XX), the mean global health status/QoL score was XX. Functional domains such as emotional and physical functioning were notably compromised. Symptoms such as fatigue, pain, and arm swelling were prevalent. Lower QoL scores were significantly associated with advanced stage at diagnosis, comorbidities, and recent completion of treatment (p < 0.05). Conclusion: Breast cancer survivors face ongoing challenges that impair their quality of life and functional capacity. Integration of routine QoL assessments into follow-up care and provision of psychosocial support services are essential for holistic survivorship care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ayesha_2025,

title = {A case series on rhinoscelroma at tertiary care hospital at Hyderabad},

author = {Syeda Ayesha},

url = {https://www.ijmedph.org/Uploads/Volume15Issue1/154.%20[1589.%20IJMEDPH_Adnan]%20826-828.pdf},

doi = {10.70034/ijmedph.2025.1.154},

issn = {2230-8598},

year  = {2025},

date = {2025-03-31},

urldate = {2025-03-31},

journal = {International Journal of Medicine and Public Health},

volume = {15},

issue = {1},

pages = {826-828},

abstract = {Rhinoscleroma is a long-lasting, progressive inflammatory disorder affecting the upper respiratory tract, linked to the Klebsiella rhinoscleromatis infection. This case series outlines the clinical and pathological characteristics seen in four patients diagnosed with rhinoscleroma at the Deccan College of Medical Sciences in Hyderabad from 2020 to 2024. Each patient exhibited cutaneous symptoms exclusively, and histological analysis confirmed the diagnosis. The patients were treated with a combination of antibiotics. Due to the rarity of rhinoscleroma in Hyderabad, diagnosing it can be quite challenging. This report aims to increase awareness about the disease to facilitate early diagnosis and treatment for those affected. Without proper intervention, rhinoscleroma can result in serious complications, such as involvement of the lower airways. Therefore, early detection and prompt treatment are crucial for reducing the morbidity associated with this condition.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ayesha_2025b,

title = {Fungal otitis externa as a cause of tympanic membrane perforation: a case series},

author = {Syeda Ayesha},

url = {https://www.ijmedph.org/Uploads/Volume15Issue1/175.%20[1546.%20IJMEDPH_Adnan]%20939-940.pdf},

doi = {10.70034/ijmedph.2025.1.175 },

issn = {2230–8598},

year  = {2025},

date = {2025-03-31},

urldate = {2025-03-31},

journal = {International Journal of Medicine and Public Health},

volume = {15},

issue = {1},

pages = {939-940},

abstract = {This report talks about 13 patients who had a serious ear infection caused by fungus, which led to holes in their eardrums. The group included 10 men and 3 women, aged between 18 and 70 years, with an average age of 49. These patients had ongoing ear problems that did not get better with usual treatments. They experienced symptoms like ear discharge, ear pain, and itching. Out of the 13 patients, six had no previous ear issues. Four were sent to specialists by their family doctors, five came from ear doctors, and three came on their own. Treatment included careful cleaning of the ears and one of two types of  antifungal medicine. After treatment, nine patients fully recovered, including healing their eardrum holes. However, three patients needed surgery to fix their eardrums. This study shows that fungal ear infections can be hard to diagnose, but with the right medical care, most eardrum holes caused by this infection can heal without needing surgery. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Raheem_2025,

title = {COVID-19 vaccine hesitancy among medical and nonmedical undergraduate students: a cross-sectional study},

author = {Juwairiah Abdur Raheem and Saimah Naseer and Mohammed Imtiyazuddin and Mehnaaz Sameera Arifuddin},

url = {https://journals.lww.com/mjhs/fulltext/2025/07000/covid_19_vaccine_hesitancy_among_medical_and.14.aspx},

doi = {10.4103/mjhs.mjhs_60_24},

issn = {2321-7006},

year  = {2025},

date = {2025-03-29},

urldate = {2025-03-29},

journal = {MRIMS Journal of Health Sciences},

volume = {13},

issue = {3},

pages = {162-165},

abstract = {Vaccine hesitancy poses a threat to not only one’s life but also others surrounding them. Vaccine hesitancy is indirectly related to vaccine coverage, and it is therefore important to reduce it by finding out its prevalence and root cause. The objective was to compare the burden and reasons for vaccine hesitancy among medical and nonmedical students. A cross-sectional study was conducted. Data were collected using Google Forms forwarded to medical and nonmedical students through various social media platforms over 3 months. COVID-19 vaccine hesitancy was 33.51% in medical students compared to 66.48% in nonmedical students. About 5.67% of medical and 18.64% of non-medical students who refused vaccine was due to their fears on the effectiveness of the vaccine. We conclude that nonmedical students exhibited greater vaccine hesitancy compared to medical students. A primary concern was about vaccine’s impact on genetics and doubts about its effectiveness, stemming from perceptions of rushed trials.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025,

title = {Anaesthesia management of a primigravida with scoliosis posted for elective caesarean section},

author = {Naseeba Fatima and Shaikh Wasim Akram and U. Jayashree and Shireen Adeeb Mujtaba Ali},

url = {https://journals.lww.com/sbvj/fulltext/2025/01000/anaesthesia_management_of_a_primigravida_with.10.aspx},

doi = {10.4103/sbvj.sbvj_12_25},

issn = {2581-6039},

year  = {2025},

date = {2025-03-23},

urldate = {2025-01-01},

journal = {SBV Journal of Basic, Clinical and Applied Health Science},

volume = {8},

issue = {1},

pages = {30–32},

publisher = {Wolters Kluwer Health},

abstract = {Scoliosis is a condition which could be congenital or acquired associated with other system involvement mainly cardiopulmonary and nervous system based on the level and extent of involvement. We report a case of 22-year-old primigravida with severe thoracolumbar scoliosis scheduled for elective lower segment cesarean section. The anesthetic management was under subarachnoid block without any sedation, and it was uneventful.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bangi_2025,

title = {A study of serum magnesium levels in patients with acute myocardial infarction in the rural population of Vijayapura district},

author = {Sayed Mohammed Hussain Bangi and Mohammed Hidayathulla and Abhishek Golla and Syeda Tasneem Kausar and Parvaiz Kadloor},

url = {https://ijcva.org/pdf/1fe4afca-adad-4137-be7c-36a5e5ab6910/articles/ijca.2024.96268/23-28.pdf},

doi = {10.4274/ijca.2024.96268},

issn = {2405-819X},

year  = {2025},

date = {2025-03-18},

urldate = {2025-03-18},

journal = {International Journal of Cardiovascular Academy},

volume = {11},

issue = {1},

pages = {23-28},

abstract = {Background and Aim: Magnesium is an essential element for the proper functioning and regulation of cardiovascular physiology. It acts as a vital helper molecule in various enzyme systems and is involved in multiple cardiovascular processes. These processes include intracardiac conduction, myocardial contraction, atherogenesis, thrombosis, regulation of vascular tone, and the proliferation and migration of endothelial cells and vascular smooth muscle. The aim of this study was to evaluate the relationship between serum magnesium concentration and their correlation with complications and in-hospital outcomes in acute myocardial infarction (AMI) patients.

Materials and Methods: This observational study included patients who were admitted to a tertiary care centre in India from December 2019 to September 2021. A total of 100 patients with AMI were enrolled in the study. Serum magnesium concentration was assessed using the calmagite method. The patients were followed up for 7 days during their hospitalization to monitor complications and in-hospital outcomes.

Results:The serum magnesium concentration was between 1.1 mg/dL and 4.0 mg/dL. There were 28 patients with hypomagnesemia and 11 patients with hypermagnesemia. The study population consisted of 57% male, and the majority of patients were in the age group of 60-80 years (38%). A typical clinical presentation was observed in 61% of the patients, while 39% of patients displayed an atypical clinical presentation. Higher proportions of patients with typical clinical presentation were significantly observed to have hypomagnesemia (P = 0.037). Among the total patient population, 20% experienced QT-prolongation in our study. Patients with hypomagnesemia experienced more complications, but patients with hypermagnesemia were associated with an increased rate of mortality.

Conclusion: In patients with AMI, hypomagnesemia was associated with an increased incidence of complications. Conversely, hypermagnesemia was linked to increased mortality among patients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kari_2025,

title = {A dosimetric analysis on supine and prone positions in carcinoma cervix patients using intensity-modulated radiotherapy at a tertiary cancer centre},

author = {Nagasai Divya Kari and Mohd. Asimuddin and Sai Teja Adepu and M. Ramakrishna},

url = {https://jccpractice.com/article/a-dosimetric-analysis-on-supine-and-prone-positions-in-carcinoma-cervix-patients-using-intensity-modulated-radiotherapy-at-a-tertiary-cancer-centre-585/},

doi = {10.61336/jccp/25-02.63},

issn = {2457-7200},

year  = {2025},

date = {2025-02-28},

urldate = {2025-02-28},

journal = {Journal of Contemporary Clinical Practice},

volume = {11},

issue = {2},

pages = {477-488},

abstract = {Background:  Radiotherapy remains a cornerstone in the management of carcinoma cervix, with patient positioning playing a crucial role in dosimetric outcomes. Proper positioning during radiotherapy can significantly influence the dose distribution to the target volumes and organs at risk (OARs), potentially impacting treatment efficacy and toxicity.  Aim:  To evaluate and compare the dosimetric parameters of supine and prone positions in carcinoma cervix patients undergoing intensity-modulated radiotherapy (IMRT) at a tertiary cancer center, with a focus on optimizing target volume coverage and minimizing radiation exposure to organs at risk. Methods and Materials:  This was a prospective study conducted at MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, over a period of 24 months. A total of 25 patients with carcinoma cervix were enrolled.  Patients included in the study were aged 30–65 years, with histopathologically confirmed stage IB-IIIB carcinoma cervix (FIGO guidelines), and a performance status of 1–3 as per Eastern Cooperative Oncology Group criteria. All patients had normal blood, liver, and kidney function tests. Patients with stage IA, IIIC, or IV disease, distant metastasis, poor performance status, synchronous malignancies, or HIV positivity were excluded. Radiotherapy planning involved CT simulation scans in both supine and prone positions using immobilization devices. Target volumes and OARs were delineated according to international guidelines, and dosimetric parameters were analyzed for both positions. Results:  The mean PTV volume was slightly higher in the prone position (1616.68 ± 172.85 cc) compared to the supine position (1561 ± 186.50 cc). Dose coverage was comparable, with PTV 95% being 95.896% in the prone position and 97.669% in the supine position. However, prone positioning provided better sparing of the small bowel, with lower dose-volume metrics across all thresholds (e.g., V50: prone 1.7%, supine 5.7%). The bladder dose metrics were similar, with V10 being 100% in both positions, but V45 was slightly lower in the prone position (43%) compared to the supine position (50%). For the rectum, prone positioning significantly reduced exposure at higher doses (e.g., V50: prone 4.5%, supine 7.4%). Conclusion:  The prone position demonstrated superior sparing of the small bowel and rectum while maintaining comparable dose coverage for target volumes and bladder. These findings suggest that prone positioning can enhance IMRT treatment efficacy and reduce toxicity in carcinoma cervix patients, offering a potentially improved therapeutic ratio.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Study of coronary arteries in human cadavers: A cross-sectional study},

author = {Kannan Subramanian and Syeda Tasneem Kauser and Mohammed Hidayathullah and Priyanka Bhaskar},

url = {http://impactfactor.org/PDF/IJCPR/17/IJCPR,Vol17,Issue2,Article109.pdf},

issn = {2961-6042},

year  = {2025},

date = {2025-02-11},

journal = {International Journal of Current Pharmaceutical Review and Research},

volume = {17},

issue = {2},

pages = {665-671},

abstract = {Introduction: The word ‘coronary’ is derived from the Latin word co-ro-ne. “Corona” meaning “Crown”. The coronary arteries are the main blood supply to the heart and are known for its variations in both its origin as well as its branching pattern. The right coronary artery most commonly arises from the right aortic sinus and the left coronary artery arises from the left posterior aortic sinus. Anomalous origin of the coronaries and its branching pattern have been associated with increased incidence of coronary vascular events. This study is a cross-sectional study done in 60 cadaveric hearts to study the origin and variations in the coronary arteries. Materials and Methods: Randomly selected 60 formalin   fixed hearts (preserved heart specimens and hearts from cadavers which were used for dissection teaching) were obtained from the Department of Anatomy. Meticulous dissection was done and the origin along with the course and branching of both the right and left coronary arteries and the coronary dominance were noted. Conclusion: The coronary artery disease is one of the major  cause of death. Both sedentary and stressful type of lifestyle is a risk factor. Coronary dominance is important because inferior wall myocardial infarctions are common. The knowledge of the origin, branching pattern and the coronary dominance gives an insight to the cardiologists while performing angiography for more comprehensive treatment of the patients with coronary artery disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2025,

title = {Diaphragmatic myoclonus effectively treated with lacosamide: a very rare phenomenon of belly dancer syndrome},

author = {Sandhya Manorenj and Bushra Naaz and Manju Madhavan},

url = {https://journals.lww.com/neur/fulltext/2025/01000/diaphragmatic_myoclonus_effectively_treated_with.26.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00458},

issn = {0028-3886},

year  = {2025},

date = {2025-02-07},

urldate = {2025-02-07},

journal = {Neurology India},

volume = {73},

issue = {1},

pages = {149-151},

abstract = {Diaphragmatic myoclonus, also called diaphragmatic flutter, has characteristic abdominal movements resembling those of a belly dancer; hence, it is also called belly dancer syndrome (BDS). BDS is characterized by high-frequency involuntary diaphragmatic contractions. BDS can occur due to a lesion anywhere in the pathway for diaphragmatic control, from the motor cortex to the neural supply to the diaphragm. Here we report a 21-year-old girl who presented with acute-onset abdominal movements of 5 days duration. Clinical examination showed abdominal jerky movements with preserved awareness. Electroencephalograms (EEG) showed polyspike wave discharges consistent with cortical myoclonus. These abdominal myoclonic jerks disappeared dramatically on treatment with lacosamide, a third-generation antiepileptic drug. There are few case reports of BDS in the literature with a cortical myoclonus origin instead of the widely described segmental myoclonus form. The case also highlights the efficacy of lacosamide in treating diaphragmatic myoclonus jerk in young adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2025b,

title = {Acquired hepatocerebral degeneration and accumulation of manganese},

author = {Sandhya Manorenj and Sravan Kumar Marupaka},

url = {https://journals.lww.com/annalsofian/fulltext/2025/01000/acquired_hepatocerebral_degeneration_and.17.aspx},

doi = {10.4103/aian.aian_633_24},

issn = {0972-2327},

year  = {2025},

date = {2025-01-02},

urldate = {2025-01-02},

journal = {Annals of Indian Academy of Neurology},

volume = {28},

issue = {1},

pages = {107-109},

abstract = {A 43-year-old man with chronic liver disease (CLD) due to alcoholism and hepatitis B virus (HBV) infection presented at the emergency department after experiencing a generalized tonic–clonic seizure and altered consciousness. He had been diagnosed with adult-onset epilepsy 3 years ago and was taking medication for seizure, which he had missed 2 days before. In addition, he was being treated with entecavir for the HBV infection.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024g,

title = {Efficacy and safety of tenecteplase versus alteplase in acute ischemic stroke: evidence from a South Indian cohort},

author = {Sandhya Manorenj and Maryam and Iqra Jahan and Syeda Noor Fatima and Yumna Fatima and Mir Wajahath Ali},

url = {https://rjn.com.ro/articles/2024.4/RJN_2024_4_Art-13.pdf},

doi = {10.37897/RJN.2024.4.13},

issn = {1843-8148},

year  = {2024},

date = {2024-12-26},

urldate = {2024-12-26},

journal = {Romanian Journal of Neurology},

volume = {23},

issue = {4},

pages = {403-409},

abstract = {Background. Acute ischemic stroke (AIS) requires efficient thrombolytic therapy to re-establish vascular permeability and mitigate tissue damage. Alteplase and tenecteplase are prominent tissue plasminogen activators (tPAs) employed in this clinical scenario. This study compares these two agents, focusing on their efficacy, safety profiles, time parameters, and rates of re-hospitalization.

Objectives. To compare the efficacy and safety of tenecteplase versus alteplase for treating acute ischemic stroke in South Indian patients: a prospective study.

Methods. At a single center, we conducted a prospective, observational, non-interventional study of patients receiving thrombolytics alteplase or tenecteplase from November 2023 to July 2024, which included patients within a 4.5-hour window of symptom onset. The principal outcome of this study is to evaluate early neurological improvement using the clinical assessment scales – the National Institutes of Health Stroke Scale (NIHSS) at baseline and 24 hours, and the Modified Rankin Scale (mRS) at admission and 3 months. The secondary outcomes include the door-to-needle time (DTN) and assessing the need for re-hospitalization. Data was scrutinized using a t-test and median interquartile range (IQR).

Results. The study enrolled 64 patients, 32 treated with alteplase and 32 with tenecteplase. Statistical significance was found for the efficacy of the drugs (NIHSS post-treatment p = 0.01 and mRS p = 0.002). The DTN and re-hospitalization were found to be non-significant.

Conclusion. Both alteplase and tenecteplase efficiently manage AIS, with tenecteplase demonstrating advantages in early neurological improvement, ease of administration, and cost-effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kulkarni_2024,

title = {Attitude of caregivers, psychiatrists, and nurses toward coercive measures: an observational, survey-based comparative study},

author = {Sneha Kulkarni and M. Uma Shankar and Ravi Kumar Dabbiru and Ramsubba Reddy and Sireesha Srinivasa Rao and Minhajzafar Nasirabadi},

url = {https://journals.lww.com/tjpy/fulltext/2024/10020/attitude_of_caregivers,_psychiatrists,_and_nurses.9.aspx},

doi = {10.4103/tjp.tjp_4_24},

issn = {2455-8559},

year  = {2024},

date = {2024-12-21},

urldate = {2024-12-21},

journal = {Telangana Journal of Psychiatry},

volume = {10},

issue = {2},

pages = {143-150},

abstract = {Objectives: The primary objective was to compare the attitude of health-care providers (psychiatrists and nursing staff) and caregivers.

Materials and Methods: This prospective, survey-based study used the Staff Attitude to Coercion Scale, Morisky Medication Adherence Rating Scale, Oslo Social Support Scale, and the Modified Overt Aggression Scale.

Results: Participants (326) included psychiatrists (32.51%), staff nurses (35.58%), and caregivers (31.90%). Health-care professionals scored higher in offense and safety subscale (psychiatrists 3.2 and 5.55; nurses 3.12 and 5.65) compared to caregivers (2.46 and 5.10). In coercion as treatment subscale, caregivers scored least (0.78) (psychiatrists 1.15, nurses 1.92). The difference in these subscales was statistically significant (P = 0.001). There was no significant influence of social support and level of education of caregivers on the use of physical restraint. Of 104 patients, 58.65% were brought with physical restraint. Treatment compliance (n = 85) in stabilized patients was 84.7%.

Conclusion: According to health-care providers, the use of coercion was offensive; coercion can be reduced by improving the resources and giving more personal time. All groups acknowledged that coercion infringes on patients’ human rights but supported its use when necessary for ensuring patient care and safety in the environment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Adepu_2025,

title = {A study on information needs, evaluation of quality of life and pain assessment in patients with metastatic cancer receiving palliative radiotherapy},

author = {Sai Teja Adepu and Nagasai Divya Kari and Mohd. Asimuddin and M. Ramakrishna and Kanugula Sravanthi},

url = {https://jccpractice.com/article/a-study-on-information-needs-evaluation-of-quality-of-life-and-pain-assessment-in-patients-with-metastatic-cancer-receiving-palliative-radiotherapy-232/},

doi = {10.18683/jccp.2024.1091/2.36},

issn = {2457-7200},

year  = {2024},

date = {2024-12-21},

urldate = {2024-12-21},

journal = {Journal of Contemporary Clinical Practice},

volume = {10},

issue = {2},

pages = {256-263},

abstract = {Background: Metastatic cancer often leads to debilitating symptoms, including pain and compromised quality of life (QoL). Palliative radiotherapy (RT) serves as a critical intervention to alleviate symptoms and enhance QoL. Understanding patient-specific information needs, assessing pain, and evaluating QoL pre- and post-RT are essential for optimizing patient-centered care. Aim:  This study aims to assess the information needs, pain levels, and QoL of patients with metastatic cancer undergoing palliative RT and to evaluate the changes in QoL and pain scores before and after RT. Materials and Methods:  A prospective study was conducted from 2019 to 2020 at MNJ Institute of Oncology and Regional Cancer Centre, involving 50 patients with histologically confirmed metastatic cancers (age 18–75, ECOG performance score 1–3). Patients completed Cassileth’s Information Needs Questionnaire to assess information requirements, the Numeric Pain Scale for pain evaluation, and the EORTC QLQ-C30 questionnaire for QoL assessment before RT and one month after its completion. Statistical analysis was performed using SPSS version 22.0. Results:  The majority (88%) of patients expressed a strong need to know whether the illness was cancer, and 82% wanted to know the specific medical name of their illness. Pain scores significantly improved after RT (mean pain score pre-RT: 59.42; post-RT: 32.4; p=0.000). QoL assessment showed statistically significant improvements in Global Health Status (p=0.032), Physical Functioning (p=0.003), Role Functioning (p=0.002), Emotional Functioning (p=0.016), and Cognitive Functioning (p=0.008). Symptom scales showed significant improvement in fatigue (p=0.000), pain (p=0.000), dyspnea (p=0.034), appetite loss (p=0.047), diarrhea (p=0.009), and insomnia (p=0.018). Constipation worsened slightly, though not significantly (p=0.497). Conclusion:  Cancer patients consistently desired comprehensive information about their diagnosis and treatment options, regardless of age, education, socioeconomic status, or prognosis. Among those with metastatic cancers, palliative radiotherapy significantly improved quality of life, particularly by alleviating pain, the most common symptom.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2024d,

title = {A pseudo guillain barre syndrome (GBS) presentation of sjogren’s syndrome},

author = {Reshma Sultana Shaik and Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/11000/a_pseudo_guillain_barre_syndrome__gbs_.29.aspx},

doi = {10.4103/ni.ni_4_23},

issn = {0028-3886},

year  = {2024},

date = {2024-12-17},

urldate = {2024-12-17},

journal = {Neurology India},

volume = {72},

issue = {6},

pages = {1283-1284},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2024b,

title = {Seroprevalence of SARS-CoV-2 IgG antibodies in health care workers and the associated risk factors during the covid-19 pandemic period at a tertiary care heatlh center in South India},

author = {Sarwat Fatima and Ahmed Abdul Bari Hazari and Deepika Handa},

url = {https://pdf.ipinnovative.com/pdf/23488},

doi = {10.18231/j.ijmmtd.2024.056 },

issn = {2581-4753 },

year  = {2024},

date = {2024-12-12},

urldate = {2024-12-12},

journal = {IP International Journal of Medical Microbiology and Tropical Diseases},

volume = {10},

issue = {4},

pages = {329-336},

abstract = {Background: Most of the published studies across the globe so far have demonstrated a highly variable seroprevalence rate of SARS-CoV-2 IgG antibodies in health care workers [HCW’s] during the pandemic period. Multiple risk factors were studied that influenced the seropositivity. 

Aim & Objective: The primary aim of the study was to determine the seroprevalence of SARS-CoV-2 IgG in HCW’s in local settings during the pandemic period. The secondary objective was to categorize the HCW’s based on the history of symptoms of covid-19 and also to evaluate the relation between the various risk factors and seropositivity amongst the HCW’s.

Materials and Methods: A cross sectional prospective study was conducted on health care workers at a tertiary care hospital in Telangana state during the pandemic period between March to April 2021. Following enrollment and verbal consent from the participants descriptive data was collected using a validated questionnaire. SARS-CoV-2 IgG antibodies estimation was done using ELFA technology after obtaining IERB clearance.

Results: Of the 230 enrolled participants 141 [61.30%] fulfilled the inclusion criteria. The overall SARS-CoV-2 IgG seropositivity in the present study was 48 [34.04%]. Of the 72 [51.06%] symptomatic HCW’s, 19 [26.38%] were seropositive and of the 69 [48.93%] asymptomatic, 29 [42.02%] were seropositive. Among the various risk factors studied none were found to be significantly associated with seropositivity.

Conclusion: in the present study a greater number of asymptomatic HCW’s were found seropositive which could be due to several of the reasons discussed below one being silent transmission of the virus and demands further enquiry into the cause by improved research methodology.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Golla_2024,

title = {Impact of diabetes on clinical characteristics and angiographic findings in young adults with ST-elevation myocardial infarction: a cross-sectional study},

author = {Abhishek Golla and Mohammed Hidayathulla and Sowmya Chavala and Rajashekar Reddy Gurrala and Sayed Mohammed Hussain Bangi},

url = {https://www.jcdr.net/articles/PDF/20401/75961_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_OM)_PFA(IS)_PN(IS).pdf},

doi = {10.7860/JCDR/2024/75961.20401},

isbn = {0973-709X},

year  = {2024},

date = {2024-12-01},

urldate = {2024-12-01},

journal = {Journal of Clinical and Diagnostic Research},

volume = {18},

issue = {12},

pages = {OC01-OC04},

abstract = {Introduction: The prevalence of diabetes among young patients with ST-Elevation Myocardial Infarction (STEMI) is increasing, but its impact on this population remains understudied. Limited data on diabetes in young patients with STEMI exist. The presence of diabetes among young patients experiencing STEMI deserves special consideration, as it manifests with unique clinical patterns and can significantly impact their active lifestyle.

Aim: To determine the effect of diabetes and associated clinical characteristics in young patients with STEMI.

Materials and Methods: A cross-sectional study was conducted at a tertiary care centre in India between April 2018 and December 2019. Fifty-one STEMI patients aged below 40 years were enrolled and categorised into diabetic (n=23) and non diabetic (n=28) groups based on glycated haemoglobin (HbA1c) levels. Clinical characteristics, laboratory parameters and angiographic findings were compared between the groups. This study analysed continuous variables using Student’s t-test and Analysis of Variance (ANOVA) (expressed as mean±SD), and categorical variables using Chi-square or Fisher’s exact tests (shown as n, %). A p-value of < 0.05 was considered significant.

Results: The mean age was 35.6±3.4 years, with 80.4% male predominance. Diabetic patients showed higher prevalence of dyslipidaemia (p-value=0.009), hypertension (p-value=0.043), and metabolic syndrome (p-value=0.002). They also exhibited significantly higher levels of total cholesterol, triglycerides and Low-Density Lipoprotein Cholesterol (LDL-C). Anterior Wall Myocardial Infarction (AWMI) was predominant in both groups (p-value=0.442). Single-Vessel Disease (SVD) was most common, but Triple-Vessel Disease (TVD) was observed exclusively in diabetic patients (p-value=0.198). The Left Anterior Descending (LAD) artery was the most involved vessel in both groups.

Conclusion: Compared to non diabetic patients, young STEMI patients with diabetes demonstrated a more adverse cardiovascular risk profile and lipid abnormalities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Iron folic acid deficiency in pregnant women with cleft lip and palate deformities},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/iron-folic-acid-deficiency-in-pregnant-women-with-cleft-lip-and-palate-deformities/NjAxNzg=/?is=1&b1=4&k=1},

issn = {2277-8179},

year  = {2024},

date = {2024-11-30},

journal = {International Journal of Scientific Research},

volume = {13},

issue = {11},

pages = {82-84},

abstract = {The Orofacial clefts occur when the lips or the roof of the mouth do not fuse properly during the early weeks of pregnancy. There is strong evidence that periconceptional use of folic acid can prevent neural tube defects but its effect on oral clefts has generated debate. To identify factors associated with suboptimal periconceptional use of folic acid and its potential effect on oral clefts. The population-based infant cohort of the national Growing Up in Indian study, which consists of 10,134 9-month-old infants. Data collection comprised questionnaires conducted by interviewers with parents in parents' homes. Characteristics of mothers who did or did not take folic acid before and during pregnancy, as well as the effect of folic acid use on the prevalence of cleft lip and palate were recorded. The prevalence of cleft lip and palate was 1.92 (94% confidence interval [CI] = 1.21 to 2.88) per 500 9-month-olds. The odds ratio for cleft lip was 2.24-fold higher (92% CI = 1.11 to 8.10, P = 0.006) for infants of mothers who did not take folic acid during

the first 3 months of pregnancy, when compared with those who did have a folate intake during the first trimester. Folic acid use was suboptimal in 32.2% (94% CI = 32.2 to 35.1) of the sample. These findings support the hypothesis that taking folic acid may partially prevent cleft lip and palate. They are particularly relevant for GPs, because they are usually the first port of call for women before and during early pregnancy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}