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2026
Naghma, Fatima Mehnaz; Basade, Saba Zainab; Begum, Ayesha; Kekhashan, Anjum
In: Adolescencia e Saude, vol. 21, iss. 9s, pp. 100-103, 2026, ISSN: 1679-9941.
@article{Naghma_2026,
title = {Comparative diagnostic performance of first-trimester HbA1c and DIPSI for early screening of gestational diabetes mellitus: a prospective study at a tertiary care center in Telangana, India},
author = {Fatima Mehnaz Naghma and Saba Zainab Basade and Ayesha Begum and Anjum Kekhashan},
url = {https://adolescenciaesaude.com/index.php/aes/article/view/2480/1891},
doi = {10.67440/ahj.vi.2480 },
issn = {1679-9941},
year = {2026},
date = {2026-10-04},
urldate = {2026-10-04},
journal = {Adolescencia e Saude},
volume = {21},
issue = {9s},
pages = {100-103},
abstract = {Background: Detecting gestational diabetes mellitus (GDM) early in pregnancy may allow earlier risk assessment and management. Although routine screening is commonly performed at 24–28 weeks, glucose abnormalities can be present much earlier. HbA1c is a convenient biomarker that does not require fasting, while the Diabetes in Pregnancy Study Group India (DIPSI) approach is a simple non-fasting test used widely in India. This study assessed and compared the performance of first-trimester HbA1c and DIPSI using the 75-g oral glucose tolerance test (OGTT) as the reference method.
Methods: This prospective observational comparative study included pregnant women attending a tertiary teaching hospital in Telangana during the first trimester. Eligible participants underwent HbA1c measurement, DIPSI testing, and a 75-g OGTT. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), overall diagnostic accuracy, and agreement between the screening tests were evaluated.
Results: One hundred women were enrolled. The mean HbA1c was 5.42 ± 0.62%, and the mean 2-hour plasma glucose was 126.8 ± 28.5 mg/dL. The reference OGTT diagnosed GDM in 16% of participants. HbA1c classified 19% as screen-positive and had a sensitivity of 81.3% and specificity of 92.9%. DIPSI classified 15% as screen-positive and showed a sensitivity of 75.0% and specificity of 96.4%. Overall diagnostic accuracy was 91.0% for HbA1c and 93.0% for DIPSI. Agreement between the two screening methods was substantial (κ = 0.68, p < 0.001).
Conclusion: In this study population, both first-trimester HbA1c and DIPSI showed useful diagnostic performance compared with OGTT. HbA1c detected a larger proportion of OGTT-positive cases, while DIPSI showed greater specificity and slightly higher overall accuracy. HbA1c may therefore be useful as an early adjunct to glucose-based screening, while DIPSI remains a practical option in routine antenatal services.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Detecting gestational diabetes mellitus (GDM) early in pregnancy may allow earlier risk assessment and management. Although routine screening is commonly performed at 24–28 weeks, glucose abnormalities can be present much earlier. HbA1c is a convenient biomarker that does not require fasting, while the Diabetes in Pregnancy Study Group India (DIPSI) approach is a simple non-fasting test used widely in India. This study assessed and compared the performance of first-trimester HbA1c and DIPSI using the 75-g oral glucose tolerance test (OGTT) as the reference method.
Methods: This prospective observational comparative study included pregnant women attending a tertiary teaching hospital in Telangana during the first trimester. Eligible participants underwent HbA1c measurement, DIPSI testing, and a 75-g OGTT. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), overall diagnostic accuracy, and agreement between the screening tests were evaluated.
Results: One hundred women were enrolled. The mean HbA1c was 5.42 ± 0.62%, and the mean 2-hour plasma glucose was 126.8 ± 28.5 mg/dL. The reference OGTT diagnosed GDM in 16% of participants. HbA1c classified 19% as screen-positive and had a sensitivity of 81.3% and specificity of 92.9%. DIPSI classified 15% as screen-positive and showed a sensitivity of 75.0% and specificity of 96.4%. Overall diagnostic accuracy was 91.0% for HbA1c and 93.0% for DIPSI. Agreement between the two screening methods was substantial (κ = 0.68, p < 0.001).
Conclusion: In this study population, both first-trimester HbA1c and DIPSI showed useful diagnostic performance compared with OGTT. HbA1c detected a larger proportion of OGTT-positive cases, while DIPSI showed greater specificity and slightly higher overall accuracy. HbA1c may therefore be useful as an early adjunct to glucose-based screening, while DIPSI remains a practical option in routine antenatal services.
Methods: This prospective observational comparative study included pregnant women attending a tertiary teaching hospital in Telangana during the first trimester. Eligible participants underwent HbA1c measurement, DIPSI testing, and a 75-g OGTT. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), overall diagnostic accuracy, and agreement between the screening tests were evaluated.
Results: One hundred women were enrolled. The mean HbA1c was 5.42 ± 0.62%, and the mean 2-hour plasma glucose was 126.8 ± 28.5 mg/dL. The reference OGTT diagnosed GDM in 16% of participants. HbA1c classified 19% as screen-positive and had a sensitivity of 81.3% and specificity of 92.9%. DIPSI classified 15% as screen-positive and showed a sensitivity of 75.0% and specificity of 96.4%. Overall diagnostic accuracy was 91.0% for HbA1c and 93.0% for DIPSI. Agreement between the two screening methods was substantial (κ = 0.68, p < 0.001).
Conclusion: In this study population, both first-trimester HbA1c and DIPSI showed useful diagnostic performance compared with OGTT. HbA1c detected a larger proportion of OGTT-positive cases, while DIPSI showed greater specificity and slightly higher overall accuracy. HbA1c may therefore be useful as an early adjunct to glucose-based screening, while DIPSI remains a practical option in routine antenatal services.
Bathini, Gangadhar; Nazma,
In: International Journal of Medicine and Public Health, vol. 16, iss. 3, pp. 5950-5958, 2026, ISSN: 2230-8598.
@article{Bathini_2026b,
title = {Clinical profile, etiological spectrum and short-term outcomes of acute kidney injury among adults admitted to a tertiary care hospital: a prospective observational study},
author = {Gangadhar Bathini and Nazma},
url = {https://www.ijmedph.org/Uploads/Volume16Issue3/916_6600_IJMEDPH_IMRP_5950_5958.pdf},
doi = {10.70034/ijmedph.2026.3.916},
issn = {2230-8598},
year = {2026},
date = {2026-09-30},
journal = {International Journal of Medicine and Public Health},
volume = {16},
issue = {3},
pages = {5950-5958},
abstract = {Background: Acute kidney injury (AKI) is a common and potentially life-threatening complication among hospitalized adults and is associated with significant morbidity, mortality, prolonged hospitalization, and increased healthcare utilization. Its etiological spectrum varies according to patient characteristics and healthcare settings. Early recognition, identification of reversible causes, and timely management are essential for improving outcomes. The objective is to evaluate the clinical profile, etiological spectrum,
severity, management, and short-term outcomes of acute kidney injury among adults admitted to a tertiary care teaching hospital and to identify factors associated with adverse outcomes and in-hospital mortality.
Materials and Methods: This prospective observational hospital-based study was conducted in the Departments of Nephrology over 12 months from January 2025 to December 2025. A total of 160 consecutive adult patients diagnosed with AKI according to the KDIGO 2012 criteria were included. Patients with established end-stage renal disease on maintenance dialysis, CKD stage 5, kidney transplantation, or incomplete clinical data were excluded. Demographic characteristics, clinical features, comorbidities, laboratory parameters, etiological factors, KDIGO stage, treatment modalities, and hospital outcomes were recorded. Patients were followed until discharge or death. Statistical analysis was performed using SPSS version 26.0, with p<0.05 considered statistically significant. Results: The mean age of the study population was 54.8 ± 15.2 years, with a male predominance (61.3%). Hypertension (50.0%) and diabetes mellitus (45.0%) were the most common comorbidities. Generalized weakness (77.5%) and oliguria (68.8%) were the predominant presenting features. Sepsis was the leading etiology of AKI (32.5%), followed by acute gastroenteritis/dehydration (18.8%), cardiorenal syndrome (12.5%), and drug-induced nephrotoxicity (11.3%). KDIGO Stage III AKI was observed in 35.6% of patients, followed by Stage II (34.4%) and Stage I (30.0%). Conservative management was sufficient in 65.0%, while 35.0% required haemodialysis. Complete renal recovery occurred in 56.3% of patients, partial recovery in 20.0%, and 7.5% remained dialysis-dependent at discharge. In-hospital mortality was 16.2%. Increasing KDIGO stage was significantly associated with adverse outcomes (p<0.001). On multivariable analysis, ICU admission, KDIGO Stage III AKI, sepsis, hyperkalemia, haemodialysis requirement, and age >60 years were independent predictors of mortality. Conclusion: AKI among hospitalized adults was predominantly associated with sepsis and dehydration and frequently occurred in patients with metabolic and cardiovascular comorbidities. Advanced KDIGO stage, sepsis, hyperkalemia, older age, ICU admission, and the need for haemodialysis were important predictors of mortality. Early recognition, prompt treatment of reversible causes, appropriate nephrology intervention, and timely renal replacement therapy are essential to improve short-term outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Acute kidney injury (AKI) is a common and potentially life-threatening complication among hospitalized adults and is associated with significant morbidity, mortality, prolonged hospitalization, and increased healthcare utilization. Its etiological spectrum varies according to patient characteristics and healthcare settings. Early recognition, identification of reversible causes, and timely management are essential for improving outcomes. The objective is to evaluate the clinical profile, etiological spectrum,
severity, management, and short-term outcomes of acute kidney injury among adults admitted to a tertiary care teaching hospital and to identify factors associated with adverse outcomes and in-hospital mortality.
Materials and Methods: This prospective observational hospital-based study was conducted in the Departments of Nephrology over 12 months from January 2025 to December 2025. A total of 160 consecutive adult patients diagnosed with AKI according to the KDIGO 2012 criteria were included. Patients with established end-stage renal disease on maintenance dialysis, CKD stage 5, kidney transplantation, or incomplete clinical data were excluded. Demographic characteristics, clinical features, comorbidities, laboratory parameters, etiological factors, KDIGO stage, treatment modalities, and hospital outcomes were recorded. Patients were followed until discharge or death. Statistical analysis was performed using SPSS version 26.0, with p<0.05 considered statistically significant. Results: The mean age of the study population was 54.8 ± 15.2 years, with a male predominance (61.3%). Hypertension (50.0%) and diabetes mellitus (45.0%) were the most common comorbidities. Generalized weakness (77.5%) and oliguria (68.8%) were the predominant presenting features. Sepsis was the leading etiology of AKI (32.5%), followed by acute gastroenteritis/dehydration (18.8%), cardiorenal syndrome (12.5%), and drug-induced nephrotoxicity (11.3%). KDIGO Stage III AKI was observed in 35.6% of patients, followed by Stage II (34.4%) and Stage I (30.0%). Conservative management was sufficient in 65.0%, while 35.0% required haemodialysis. Complete renal recovery occurred in 56.3% of patients, partial recovery in 20.0%, and 7.5% remained dialysis-dependent at discharge. In-hospital mortality was 16.2%. Increasing KDIGO stage was significantly associated with adverse outcomes (p<0.001). On multivariable analysis, ICU admission, KDIGO Stage III AKI, sepsis, hyperkalemia, haemodialysis requirement, and age >60 years were independent predictors of mortality. Conclusion: AKI among hospitalized adults was predominantly associated with sepsis and dehydration and frequently occurred in patients with metabolic and cardiovascular comorbidities. Advanced KDIGO stage, sepsis, hyperkalemia, older age, ICU admission, and the need for haemodialysis were important predictors of mortality. Early recognition, prompt treatment of reversible causes, appropriate nephrology intervention, and timely renal replacement therapy are essential to improve short-term outcomes.
severity, management, and short-term outcomes of acute kidney injury among adults admitted to a tertiary care teaching hospital and to identify factors associated with adverse outcomes and in-hospital mortality.
Materials and Methods: This prospective observational hospital-based study was conducted in the Departments of Nephrology over 12 months from January 2025 to December 2025. A total of 160 consecutive adult patients diagnosed with AKI according to the KDIGO 2012 criteria were included. Patients with established end-stage renal disease on maintenance dialysis, CKD stage 5, kidney transplantation, or incomplete clinical data were excluded. Demographic characteristics, clinical features, comorbidities, laboratory parameters, etiological factors, KDIGO stage, treatment modalities, and hospital outcomes were recorded. Patients were followed until discharge or death. Statistical analysis was performed using SPSS version 26.0, with p<0.05 considered statistically significant. Results: The mean age of the study population was 54.8 ± 15.2 years, with a male predominance (61.3%). Hypertension (50.0%) and diabetes mellitus (45.0%) were the most common comorbidities. Generalized weakness (77.5%) and oliguria (68.8%) were the predominant presenting features. Sepsis was the leading etiology of AKI (32.5%), followed by acute gastroenteritis/dehydration (18.8%), cardiorenal syndrome (12.5%), and drug-induced nephrotoxicity (11.3%). KDIGO Stage III AKI was observed in 35.6% of patients, followed by Stage II (34.4%) and Stage I (30.0%). Conservative management was sufficient in 65.0%, while 35.0% required haemodialysis. Complete renal recovery occurred in 56.3% of patients, partial recovery in 20.0%, and 7.5% remained dialysis-dependent at discharge. In-hospital mortality was 16.2%. Increasing KDIGO stage was significantly associated with adverse outcomes (p<0.001). On multivariable analysis, ICU admission, KDIGO Stage III AKI, sepsis, hyperkalemia, haemodialysis requirement, and age >60 years were independent predictors of mortality. Conclusion: AKI among hospitalized adults was predominantly associated with sepsis and dehydration and frequently occurred in patients with metabolic and cardiovascular comorbidities. Advanced KDIGO stage, sepsis, hyperkalemia, older age, ICU admission, and the need for haemodialysis were important predictors of mortality. Early recognition, prompt treatment of reversible causes, appropriate nephrology intervention, and timely renal replacement therapy are essential to improve short-term outcomes.
Bathini, Gangadhar; Nazma,; Sadath, Saniya
In: International Journal of Medicine and Public Health, vol. 16, iss. 3, pp. 4829-4837, 2026, ISSN: 2230-8598.
@article{Bathini_2026,
title = {Clinical profile of chronic kidney disease patients undergoing hemodialysis developing intra-dialytic hypertension: a prospective observational study from a tertiary care center},
author = {Gangadhar Bathini and Nazma and Saniya Sadath},
url = {https://www.ijmedph.org/Uploads/Volume16Issue3/745_6017_IJMEDPH_IMRP_4829_4837.pdf},
doi = {10.70034/ijmedph.2026.3.745},
issn = {2230-8598},
year = {2026},
date = {2026-09-30},
urldate = {2026-09-30},
journal = {International Journal of Medicine and Public Health},
volume = {16},
issue = {3},
pages = {4829-4837},
abstract = {Background: Intradialytic hypertension (IDH) is a paradoxical increase in blood pressure occurring during or immediately after haemodialysis and is increasingly recognized as an important predictor of cardiovascular morbidity and mortality among patients with chronic kidney disease (CKD). Although several mechanisms, including volume overload, endothelial dysfunction, sympathetic overactivity, and arterial stiffness, have been implicated in its pathogenesis, limited data are available regarding the clinical profile of patients
developing intradialytic hypertension in the Indian population. Objective: To evaluate the clinical profile of chronic kidney disease patients undergoing maintenance haemodialysis who developed intradialytic hypertension. Materials and Methods: A hospital-based prospective observational study was conducted in the Department of Nephrology, Princess Esra Hospital and Owaisi Hospital, Deccan College of Medical Sciences (DCMS), Hyderabad, from January 2025 to June 2025. A total of 120 adult CKD patients on maintenance haemodialysis who fulfilled the diagnostic criteria for intradialytic hypertension were included. Demographic characteristics, clinical profile, comorbidities, dialysis-related variables, laboratory parameters, blood pressure measurements, antihypertensive therapy, and cardiovascular findings were recorded using a
structured case record form. Data were analyzed using IBM SPSS Statistics version 29.0. Continuous variables were expressed as mean ± standard deviation, while categorical variables were presented as frequencies and percentages. A p-value of <0.05 was considered statistically significant. Results: Of the 120 patients undergoing maintenance haemodialysis, 30 (25.0%) developed intradialytic hypertension, while 90 (75.0%) remained normotensive during dialysis sessions. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic
hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. Conclusion: Intradialytic hypertension is associated with a high burden of cardiovascular risk factors and dialysis-related variables among patients receiving maintenance haemodialysis. Diabetes mellitus, left ventricular hypertrophy, hypoalbuminemia, and higher ultrafiltration volumes were associated with greater intradialytic blood pressure elevation. Careful blood pressure monitoring, optimization of volume status, and individualized antihypertensive management may facilitate early identification and improved management of patients at risk for intradialytic hypertension.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Intradialytic hypertension (IDH) is a paradoxical increase in blood pressure occurring during or immediately after haemodialysis and is increasingly recognized as an important predictor of cardiovascular morbidity and mortality among patients with chronic kidney disease (CKD). Although several mechanisms, including volume overload, endothelial dysfunction, sympathetic overactivity, and arterial stiffness, have been implicated in its pathogenesis, limited data are available regarding the clinical profile of patients
developing intradialytic hypertension in the Indian population. Objective: To evaluate the clinical profile of chronic kidney disease patients undergoing maintenance haemodialysis who developed intradialytic hypertension. Materials and Methods: A hospital-based prospective observational study was conducted in the Department of Nephrology, Princess Esra Hospital and Owaisi Hospital, Deccan College of Medical Sciences (DCMS), Hyderabad, from January 2025 to June 2025. A total of 120 adult CKD patients on maintenance haemodialysis who fulfilled the diagnostic criteria for intradialytic hypertension were included. Demographic characteristics, clinical profile, comorbidities, dialysis-related variables, laboratory parameters, blood pressure measurements, antihypertensive therapy, and cardiovascular findings were recorded using a
structured case record form. Data were analyzed using IBM SPSS Statistics version 29.0. Continuous variables were expressed as mean ± standard deviation, while categorical variables were presented as frequencies and percentages. A p-value of <0.05 was considered statistically significant. Results: Of the 120 patients undergoing maintenance haemodialysis, 30 (25.0%) developed intradialytic hypertension, while 90 (75.0%) remained normotensive during dialysis sessions. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic
hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. Conclusion: Intradialytic hypertension is associated with a high burden of cardiovascular risk factors and dialysis-related variables among patients receiving maintenance haemodialysis. Diabetes mellitus, left ventricular hypertrophy, hypoalbuminemia, and higher ultrafiltration volumes were associated with greater intradialytic blood pressure elevation. Careful blood pressure monitoring, optimization of volume status, and individualized antihypertensive management may facilitate early identification and improved management of patients at risk for intradialytic hypertension.
developing intradialytic hypertension in the Indian population. Objective: To evaluate the clinical profile of chronic kidney disease patients undergoing maintenance haemodialysis who developed intradialytic hypertension. Materials and Methods: A hospital-based prospective observational study was conducted in the Department of Nephrology, Princess Esra Hospital and Owaisi Hospital, Deccan College of Medical Sciences (DCMS), Hyderabad, from January 2025 to June 2025. A total of 120 adult CKD patients on maintenance haemodialysis who fulfilled the diagnostic criteria for intradialytic hypertension were included. Demographic characteristics, clinical profile, comorbidities, dialysis-related variables, laboratory parameters, blood pressure measurements, antihypertensive therapy, and cardiovascular findings were recorded using a
structured case record form. Data were analyzed using IBM SPSS Statistics version 29.0. Continuous variables were expressed as mean ± standard deviation, while categorical variables were presented as frequencies and percentages. A p-value of <0.05 was considered statistically significant. Results: Of the 120 patients undergoing maintenance haemodialysis, 30 (25.0%) developed intradialytic hypertension, while 90 (75.0%) remained normotensive during dialysis sessions. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic
hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. The mean age of the study population was 50.8 ± 12.1 years, with a male predominance (63.3%). Diabetic nephropathy (40.0%) and hypertensive nephrosclerosis (25.8%) were the leading causes of chronic kidney disease. Patients with intradialytic hypertension had significantly higher frequencies of diabetes mellitus, dyslipidaemia, coronary artery disease, left ventricular hypertrophy, higher ultrafiltration volumes, and lower serum albumin levels compared with normotensive patients (p<0.05). Older age (>50 years) was also significantly associated with intradialytic hypertension, whereas gender, dialysis duration, dialysis frequency, and vascular access type did not show statistically significant associations. Conclusion: Intradialytic hypertension is associated with a high burden of cardiovascular risk factors and dialysis-related variables among patients receiving maintenance haemodialysis. Diabetes mellitus, left ventricular hypertrophy, hypoalbuminemia, and higher ultrafiltration volumes were associated with greater intradialytic blood pressure elevation. Careful blood pressure monitoring, optimization of volume status, and individualized antihypertensive management may facilitate early identification and improved management of patients at risk for intradialytic hypertension.
Fatima, Sarwat
Bundibugyo and Zaire Ebolavirus outbreaks: Diagnostics, medical countermeasures, and viral persistence Journal Article
In: IP International Journal of Medical Microbiology and Tropical Diseases, vol. 12, iss. 3, pp. 397-398, 2026, ISSN: 2581-4753.
@article{Fatima_2026c,
title = {Bundibugyo and Zaire Ebolavirus outbreaks: Diagnostics, medical countermeasures, and viral persistence},
author = {Sarwat Fatima},
url = {https://ijmmtd.org/archive/volume/12/issue/3/article/27591/pdf},
doi = {10.18231/j.ijmmtd.63893.1788322901 },
issn = {2581-4753},
year = {2026},
date = {2026-09-02},
urldate = {2026-09-02},
journal = {IP International Journal of Medical Microbiology and Tropical Diseases},
volume = {12},
issue = {3},
pages = {397-398},
abstract = {Not available},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Not available
Fatima, Sarwat; Mehreen, Syeda; Raza, Umaiza
In: International Journal of Science and Research, vol. 15, iss. 8, pp. 635-640, 2026, ISSN: 2319-7064.
@article{Fatima_2026d,
title = {A cross-sectional survey on self-prescribing and over-the-counter use practices of antimicrobials in the outpatient services at a tertiary care hospital},
author = {Sarwat Fatima and Syeda Mehreen and Umaiza Raza},
url = {https://www.ijsr.net/archive/v15i8/SR26808205004.pdf},
doi = {10.21275/SR26808205004},
issn = {2319-7064},
year = {2026},
date = {2026-08-31},
urldate = {2026-08-31},
journal = {International Journal of Science and Research},
volume = {15},
issue = {8},
pages = {635-640},
abstract = {Introduction: Antimicrobial resistance is a growing public health concern, and inappropriate antibiotic use remains an important contributor to this problem. Aim & objectives: This cross-sectional study assessed self-prescription and over-the-counter antibiotic use among 172 adult outpatients attending six departments of a tertiary care hospital in Hyderabad, India.
Material and methods: Data were collected through a validated 10-item questionnaire and analysed using descriptive statistics and the Pearson Chi-square test.
Results: Antibiotic self-medication was reported by 70.9% of participants, including 8% who relied on self-prescription, 26% who obtained antibiotics over the counter, and 37% who followed both practices. Influenza-like illness was the leading reason for antibiotic use, followed by genital and gastrointestinal symptoms. Azithromycin, ampicillin, amoxicillin, and ciprofloxacin were among the commonly used antibiotics. Age and gender showed no statistically meaningful association with self-medication, whereas socioeconomic status and literacy were strongly associated with these practices. Knowledge of correct dosage, frequency, and treatment duration was generally poor, and many participants failed to complete the prescribed course. Nearly 64% of those who self-medicated later sought medical care because treatment was unsuccessful.
Conclusion and recommendations: The high level of unguided antibiotic use calls for stronger control over non-prescription antibiotic sales, better public awareness, and wider studies to guide measures aimed at reducing inappropriate antibiotic use and antimicrobial resistance.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Antimicrobial resistance is a growing public health concern, and inappropriate antibiotic use remains an important contributor to this problem. Aim & objectives: This cross-sectional study assessed self-prescription and over-the-counter antibiotic use among 172 adult outpatients attending six departments of a tertiary care hospital in Hyderabad, India.
Material and methods: Data were collected through a validated 10-item questionnaire and analysed using descriptive statistics and the Pearson Chi-square test.
Results: Antibiotic self-medication was reported by 70.9% of participants, including 8% who relied on self-prescription, 26% who obtained antibiotics over the counter, and 37% who followed both practices. Influenza-like illness was the leading reason for antibiotic use, followed by genital and gastrointestinal symptoms. Azithromycin, ampicillin, amoxicillin, and ciprofloxacin were among the commonly used antibiotics. Age and gender showed no statistically meaningful association with self-medication, whereas socioeconomic status and literacy were strongly associated with these practices. Knowledge of correct dosage, frequency, and treatment duration was generally poor, and many participants failed to complete the prescribed course. Nearly 64% of those who self-medicated later sought medical care because treatment was unsuccessful.
Conclusion and recommendations: The high level of unguided antibiotic use calls for stronger control over non-prescription antibiotic sales, better public awareness, and wider studies to guide measures aimed at reducing inappropriate antibiotic use and antimicrobial resistance.
Material and methods: Data were collected through a validated 10-item questionnaire and analysed using descriptive statistics and the Pearson Chi-square test.
Results: Antibiotic self-medication was reported by 70.9% of participants, including 8% who relied on self-prescription, 26% who obtained antibiotics over the counter, and 37% who followed both practices. Influenza-like illness was the leading reason for antibiotic use, followed by genital and gastrointestinal symptoms. Azithromycin, ampicillin, amoxicillin, and ciprofloxacin were among the commonly used antibiotics. Age and gender showed no statistically meaningful association with self-medication, whereas socioeconomic status and literacy were strongly associated with these practices. Knowledge of correct dosage, frequency, and treatment duration was generally poor, and many participants failed to complete the prescribed course. Nearly 64% of those who self-medicated later sought medical care because treatment was unsuccessful.
Conclusion and recommendations: The high level of unguided antibiotic use calls for stronger control over non-prescription antibiotic sales, better public awareness, and wider studies to guide measures aimed at reducing inappropriate antibiotic use and antimicrobial resistance.
Mohiuddin, Mohammed Fahad; Anjum, Nishat; Hussain, Mohammed Sarfaraz; Mohiuddin, Leenah; Shaik, Noor Mariam; Begum, Nadira
The great imitator: acute intermittent porphyria presenting with PRES and hypertensive crisis Journal Article
In: Journal of Contemporary Clinical Practice, vol. 12, iss. 8, pp. 99-102, 2026, ISSN: 2457-7200.
@article{Mohiuddin_2026,
title = {The great imitator: acute intermittent porphyria presenting with PRES and hypertensive crisis},
author = {Mohammed Fahad Mohiuddin and Nishat Anjum and Mohammed Sarfaraz Hussain and Leenah Mohiuddin and Noor Mariam Shaik and Nadira Begum},
url = {https://www.jccpractice.com/article/the-great-imitator-acute-intermittent-porphyria-presenting-with-pres-and-hypertensive-crisis-2208/},
doi = {10.61336/jccp/26-8-15},
issn = {2457-7200},
year = {2026},
date = {2026-08-05},
urldate = {2026-08-05},
journal = {Journal of Contemporary Clinical Practice},
volume = {12},
issue = {8},
pages = {99-102},
abstract = {Acute intermittent porphyria (AIP) is a rare metabolic disorder that presents with nonspecific neurovisceral manifestations, often leading to delayed diagnosis. We report a 14-year-old female presenting with recurrent seizure-like episodes, severe abdominal pain, persistent hypertension, and hyponatremia. Initial evaluation for structural, infectious, and autoimmune causes was unremarkable.Further metabolic workup revealed elevated urinary delta-aminolevulinic acid and positive urinary porphobilinogen, confirming the diagnosis of AIP. The patient was managed with seizure control, antihypertensive therapy, correction of electrolyte imbalance, and high-carbohydrate therapy, with subsequent clinical improvement.This case underscores the importance of considering AIP in adolescents presenting with unexplained seizures and abdominal pain, particularly when associated with hyponatremia and autonomic instability. Early diagnosis and appropriate management are critical to preventing complications and avoiding the use of contraindicated medications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Acute intermittent porphyria (AIP) is a rare metabolic disorder that presents with nonspecific neurovisceral manifestations, often leading to delayed diagnosis. We report a 14-year-old female presenting with recurrent seizure-like episodes, severe abdominal pain, persistent hypertension, and hyponatremia. Initial evaluation for structural, infectious, and autoimmune causes was unremarkable.Further metabolic workup revealed elevated urinary delta-aminolevulinic acid and positive urinary porphobilinogen, confirming the diagnosis of AIP. The patient was managed with seizure control, antihypertensive therapy, correction of electrolyte imbalance, and high-carbohydrate therapy, with subsequent clinical improvement.This case underscores the importance of considering AIP in adolescents presenting with unexplained seizures and abdominal pain, particularly when associated with hyponatremia and autonomic instability. Early diagnosis and appropriate management are critical to preventing complications and avoiding the use of contraindicated medications.
Khair, Ummul; Razvi, Fatima; Haneef, Nayeem Sadath
In: Cosmoderma, vol. 6, pp. 91, 2026, ISSN: 2769-5085.
@article{Khair_2026b,
title = {A randomized, prospective, comparative study of topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in localized cutaneous lichen planus},
author = {Ummul Khair and Fatima Razvi and Nayeem Sadath Haneef},
url = {https://cosmoderma.org/a-randomized-prospective-comparative-study-of-topical-clobetasol-propionate-0-05-versus-topical-tacrolimus-0-1-in-localized-cutaneous-lichen-planus/},
doi = {10.25259/csdm_123_2026},
issn = {2769-5085},
year = {2026},
date = {2026-08-04},
urldate = {2026-08-01},
journal = {Cosmoderma},
volume = {6},
pages = {91},
publisher = {Scientific Scholar},
abstract = {
Objectives:
To compare the efficacy and safety of topical clobetasol propionate 0.05% (w/w) versus topical tacrolimus 0.1% (w/w) ointment in the treatment of localized cutaneous lichen planus (CLP).
Materials and Methods:
This was a randomized, prospective, open-label study conducted in a tertiary-level hospital over 18 months, with each patient receiving 6 weeks of treatment. A total of 106 patients with localized cutaneous lichen planus meeting the selection criteria were enrolled and assigned to apply either clobetasol propionate 0.05% (Group A, n=53) or tacrolimus 0.1% (Group B, n=53) ointment twice daily for 6 weeks. Efficacy was measured using visual analog scale (VAS) scores for pruritus and lesion thickness every 2 weeks for 6 weeks, and improvement percentages were calculated. Adverse effects were also recorded.
Results:
At 6 weeks, Group A exhibited an 88% mean improvement compared to 53% in Group B (p <0.01). Complete clearance was achieved in 58.49% of Group A patients versus only 9.43% in Group B. However, in Group B, despite a complete clearance rate of only 9.43%, moderate to marked improvement was seen in nearly 40% (30.19% moderate and 9.43% marked improvement). Adverse effects were more common in Group A (66%) than in Group B (17%).
Conclusion:
In our study, both groups showed improvement; however, clobetasol propionate 0.05% demonstrated superior efficacy compared to tacrolimus 0.1% for localized cutaneous lichen planus, though it was associated with more frequent side effects. Tacrolimus may serve as a safer alternative or adjunct, particularly for atrophy-prone areas such as the face and intertriginous regions. To the best of our knowledge, this is one of the first prospective studies comparing topical clobetasol propionate 0.05% and topical tacrolimus 0.1% ointment in patients with cutaneous lichen planus.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Objectives:
To compare the efficacy and safety of topical clobetasol propionate 0.05% (w/w) versus topical tacrolimus 0.1% (w/w) ointment in the treatment of localized cutaneous lichen planus (CLP).
Materials and Methods:
This was a randomized, prospective, open-label study conducted in a tertiary-level hospital over 18 months, with each patient receiving 6 weeks of treatment. A total of 106 patients with localized cutaneous lichen planus meeting the selection criteria were enrolled and assigned to apply either clobetasol propionate 0.05% (Group A, n=53) or tacrolimus 0.1% (Group B, n=53) ointment twice daily for 6 weeks. Efficacy was measured using visual analog scale (VAS) scores for pruritus and lesion thickness every 2 weeks for 6 weeks, and improvement percentages were calculated. Adverse effects were also recorded.
Results:
At 6 weeks, Group A exhibited an 88% mean improvement compared to 53% in Group B (p <0.01). Complete clearance was achieved in 58.49% of Group A patients versus only 9.43% in Group B. However, in Group B, despite a complete clearance rate of only 9.43%, moderate to marked improvement was seen in nearly 40% (30.19% moderate and 9.43% marked improvement). Adverse effects were more common in Group A (66%) than in Group B (17%).
Conclusion:
In our study, both groups showed improvement; however, clobetasol propionate 0.05% demonstrated superior efficacy compared to tacrolimus 0.1% for localized cutaneous lichen planus, though it was associated with more frequent side effects. Tacrolimus may serve as a safer alternative or adjunct, particularly for atrophy-prone areas such as the face and intertriginous regions. To the best of our knowledge, this is one of the first prospective studies comparing topical clobetasol propionate 0.05% and topical tacrolimus 0.1% ointment in patients with cutaneous lichen planus.
Pandey, Seema; Ranjan, Megha; Naghma, Fatima Mehnaz; Thaher, M. A.
Opportunistic screening during the antenatal period for abnormal cervical cytology at a tertiary care centre Journal Article
In: International Journal of Clinical Obstetrics and Gynaecology, vol. 10, iss. 5, pp. 191-193, 2026, ISSN: 2522-6614.
@article{Pandey_2026,
title = {Opportunistic screening during the antenatal period for abnormal cervical cytology at a tertiary care centre},
author = {Seema Pandey and Megha Ranjan and Fatima Mehnaz Naghma and M. A. Thaher},
url = {https://www.gynaecologyjournal.com/articles/2865/10-5-24-708.pdf},
doi = {10.33545/gynae.2026.v10.i5c.2865},
issn = {2522-6614},
year = {2026},
date = {2026-07-31},
urldate = {2026-07-31},
journal = {International Journal of Clinical Obstetrics and Gynaecology},
volume = {10},
issue = {5},
pages = {191-193},
abstract = {Background: Cervical cancer remains a leading cause of cancer morbidity and mortality among women in India. Antenatal care may provide an opportunistic platform for cervical-cancer screening, but data on feasibility, acceptance, and cytological yield in local settings are limited.
Methods: This hospital-based prospective observational study was conducted in the Department of Obstetrics and Gynaecology, NIIMS Hospital, Noida. Pregnant women attending the antenatal clinic were offered cervical cytology (Pap smear) after written informed consent. Women with active vaginal bleeding, known cervical pathology, screening within the last 3 years, antepartum haemorrhage, premature rupture of membranes, active labour, or refusal were excluded. Data on acceptance, procedure time, complications, and cytology results were analysed. Categorical variables were presented as frequency and percentage; continuous variables as mean and standard deviation.
Results: Eighty antenatal women were offered screening; 29 underwent Pap smear testing (uptake 36.3%). The mean procedure time was 10 minutes, and no complications were recorded. Among screened women, cytology showed: NILM 17.2% (5/29), LSIL 20.7% (6/29), inflammatory smear 62.1% (18/29), and no ASC-US. When inflammatory smears are reported separately from epithelial abnormalities, the prevalence of epithelial cell abnormality was 20.7% (6/29). The main reasons for non-performance were lack of interest (80.4%) and refusal (19.6%).
Conclusion: Opportunistic cervical cytology screening during antenatal care was operationally feasible and appeared safe, with a short procedure time and no complications. However, uptake was low, primarily due to limited interest and refusal, highlighting the need for strengthened counselling and awareness interventions. Inflammatory smears were frequent; LSIL was detected in 20.7% of screened women. Antenatal services can be leveraged to identify women due for screening, provide cervical-cancer-prevention counselling, and ensure appropriate follow-up of abnormal results.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Cervical cancer remains a leading cause of cancer morbidity and mortality among women in India. Antenatal care may provide an opportunistic platform for cervical-cancer screening, but data on feasibility, acceptance, and cytological yield in local settings are limited.
Methods: This hospital-based prospective observational study was conducted in the Department of Obstetrics and Gynaecology, NIIMS Hospital, Noida. Pregnant women attending the antenatal clinic were offered cervical cytology (Pap smear) after written informed consent. Women with active vaginal bleeding, known cervical pathology, screening within the last 3 years, antepartum haemorrhage, premature rupture of membranes, active labour, or refusal were excluded. Data on acceptance, procedure time, complications, and cytology results were analysed. Categorical variables were presented as frequency and percentage; continuous variables as mean and standard deviation.
Results: Eighty antenatal women were offered screening; 29 underwent Pap smear testing (uptake 36.3%). The mean procedure time was 10 minutes, and no complications were recorded. Among screened women, cytology showed: NILM 17.2% (5/29), LSIL 20.7% (6/29), inflammatory smear 62.1% (18/29), and no ASC-US. When inflammatory smears are reported separately from epithelial abnormalities, the prevalence of epithelial cell abnormality was 20.7% (6/29). The main reasons for non-performance were lack of interest (80.4%) and refusal (19.6%).
Conclusion: Opportunistic cervical cytology screening during antenatal care was operationally feasible and appeared safe, with a short procedure time and no complications. However, uptake was low, primarily due to limited interest and refusal, highlighting the need for strengthened counselling and awareness interventions. Inflammatory smears were frequent; LSIL was detected in 20.7% of screened women. Antenatal services can be leveraged to identify women due for screening, provide cervical-cancer-prevention counselling, and ensure appropriate follow-up of abnormal results.
Methods: This hospital-based prospective observational study was conducted in the Department of Obstetrics and Gynaecology, NIIMS Hospital, Noida. Pregnant women attending the antenatal clinic were offered cervical cytology (Pap smear) after written informed consent. Women with active vaginal bleeding, known cervical pathology, screening within the last 3 years, antepartum haemorrhage, premature rupture of membranes, active labour, or refusal were excluded. Data on acceptance, procedure time, complications, and cytology results were analysed. Categorical variables were presented as frequency and percentage; continuous variables as mean and standard deviation.
Results: Eighty antenatal women were offered screening; 29 underwent Pap smear testing (uptake 36.3%). The mean procedure time was 10 minutes, and no complications were recorded. Among screened women, cytology showed: NILM 17.2% (5/29), LSIL 20.7% (6/29), inflammatory smear 62.1% (18/29), and no ASC-US. When inflammatory smears are reported separately from epithelial abnormalities, the prevalence of epithelial cell abnormality was 20.7% (6/29). The main reasons for non-performance were lack of interest (80.4%) and refusal (19.6%).
Conclusion: Opportunistic cervical cytology screening during antenatal care was operationally feasible and appeared safe, with a short procedure time and no complications. However, uptake was low, primarily due to limited interest and refusal, highlighting the need for strengthened counselling and awareness interventions. Inflammatory smears were frequent; LSIL was detected in 20.7% of screened women. Antenatal services can be leveraged to identify women due for screening, provide cervical-cancer-prevention counselling, and ensure appropriate follow-up of abnormal results.
Khair, Ummul; Haneef, Nayeem Sadath
Ecthyma-gangrenosum-like rare atypical presentation of bullous pemphigoid in a young patient with neurological disorder treated with rituximab Journal Article
In: Journal of Medical and Allied Sciences, vol. 16, iss. 2, pp. 122-125, 2026, ISSN: 2231-1696.
@article{Khair_2026,
title = {Ecthyma-gangrenosum-like rare atypical presentation of bullous pemphigoid in a young patient with neurological disorder treated with rituximab},
author = {Ummul Khair and Nayeem Sadath Haneef},
url = {https://jmas.in/?mno=316779},
doi = {10.5455/jmas.316779},
issn = {2231-1696},
year = {2026},
date = {2026-07-31},
urldate = {2026-01-01},
journal = {Journal of Medical and Allied Sciences},
volume = {16},
issue = {2},
pages = {122-125},
publisher = {Deccan College of Medical Sciences},
abstract = {Bullous pemphigoid (BP) is an autoimmune blistering disorder characterized by pruritic tense bullae, predominantly affecting the elderly. Several clinical variants have been described. Here, we report a rare ecthyma-gangrenosum-like atypical presentation of bullous pemphigoid in a young epileptic patient. A 33-year-old male farmer presented with multiple pruritic and painful erosions covered with thick adherent necrotic crust over the feet, legs, and upper limbs, sparing other body areas and mucosae, for 15 days. He reported a history of multiple tense blisters over the trunk three months earlier that had resolved with systemic corticosteroids. The patient had been receiving antiepileptic medications for eight years for generalized tonic-clonic seizures. Diagnosis of bullous pemphigoid was confirmed by characteristic complement C3c deposits at the basement membrane zone on direct immunofluorescence (DIF) of perilesional skin and subepidermal cleavage on histopathology from the earlier episode. There was no significant improvement with systemic corticosteroids, antibiotics, and supportive therapy. He was subsequently treated with rituximab, resulting in marked improvement within one month. This case of ecthyma-gangrenosum-like bullous pemphigoid is reported as it was a hitherto rarely described morphological variant occurring in a young patient with neurological association and for its excellent response to rituximab when conventional treatment was unsatisfactory.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bullous pemphigoid (BP) is an autoimmune blistering disorder characterized by pruritic tense bullae, predominantly affecting the elderly. Several clinical variants have been described. Here, we report a rare ecthyma-gangrenosum-like atypical presentation of bullous pemphigoid in a young epileptic patient. A 33-year-old male farmer presented with multiple pruritic and painful erosions covered with thick adherent necrotic crust over the feet, legs, and upper limbs, sparing other body areas and mucosae, for 15 days. He reported a history of multiple tense blisters over the trunk three months earlier that had resolved with systemic corticosteroids. The patient had been receiving antiepileptic medications for eight years for generalized tonic-clonic seizures. Diagnosis of bullous pemphigoid was confirmed by characteristic complement C3c deposits at the basement membrane zone on direct immunofluorescence (DIF) of perilesional skin and subepidermal cleavage on histopathology from the earlier episode. There was no significant improvement with systemic corticosteroids, antibiotics, and supportive therapy. He was subsequently treated with rituximab, resulting in marked improvement within one month. This case of ecthyma-gangrenosum-like bullous pemphigoid is reported as it was a hitherto rarely described morphological variant occurring in a young patient with neurological association and for its excellent response to rituximab when conventional treatment was unsatisfactory.
Zoheb, Mohammed; Reddy, S. Chandra
Brown-Vialetto-Von Laere syndrome: A case series with review of literature Journal Article
In: Journal of Medical and Allied Sciences, vol. 16, iss. 2, pp. 109-116, 2026, ISSN: 2231-1696.
@article{Zoheb_2026,
title = {Brown-Vialetto-Von Laere syndrome: A case series with review of literature},
author = {Mohammed Zoheb and S. Chandra Reddy},
url = {https://jmas.in/fulltext/154-1773046077.pdf?1787294544},
doi = {10.5455/jmas.313210},
issn = {2231-1696},
year = {2026},
date = {2026-07-31},
urldate = {2026-07-31},
journal = {Journal of Medical and Allied Sciences},
volume = {16},
issue = {2},
pages = {109-116},
publisher = {Deccan College of Medical Sciences},
abstract = {Brown-Vialetto-Van Laere syndrome (BVVL) is an exceptionally rare juvenile-onset motor neuron disease characterized by progressive ponto-bulbar palsy, sensorineural hearing loss, and multiple cranial nerve involvement, caused by mutations in riboflavin transporter genes SLC52A1, SLC52A2, and SLC52A3. Fewer than 90 cases have been documented in the literature to date. We report a familial case series of three siblings of Indian descent, born to non-consanguineous parents, presenting with bilateral lower motor neuron palsies involving cranial nerves VII, VIII, IX, X, and XII, progressive sensorineural hearing loss, dysarthria, dysphonia, and bilateral vocal cord paralysis. Notably, all three siblings reported a preceding febrile illness prior to symptom onset, a pattern previously described in the literature, though its pathophysiological significance remains uncertain. Markedly reduced plasma riboflavin levels were documented in all three patients. Clinical exome sequencing identified a heterozygous missense mutation in exon 2 of the SLC52A3 gene (chr20:g.746030A>T, p.Met130Lys) in all three siblings — a single allelic heterozygous mutation, which is an atypical and rarely symptomatic genotype. This case series is significant as it highlights that heterozygous single allelic SLC52A3 mutations can produce significant clinical manifestations, expands the phenotypic spectrum of BVVL in an Indian familial context, and underscores the critical importance of early genetic diagnosis. All three patients were initiated on high-dose riboflavin supplementation (200 mg twice daily), with the eldest reporting meaningful functional improvement. This report reinforces that timely recognition and treatment of BVVL can substantially alter disease trajectory.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Brown-Vialetto-Van Laere syndrome (BVVL) is an exceptionally rare juvenile-onset motor neuron disease characterized by progressive ponto-bulbar palsy, sensorineural hearing loss, and multiple cranial nerve involvement, caused by mutations in riboflavin transporter genes SLC52A1, SLC52A2, and SLC52A3. Fewer than 90 cases have been documented in the literature to date. We report a familial case series of three siblings of Indian descent, born to non-consanguineous parents, presenting with bilateral lower motor neuron palsies involving cranial nerves VII, VIII, IX, X, and XII, progressive sensorineural hearing loss, dysarthria, dysphonia, and bilateral vocal cord paralysis. Notably, all three siblings reported a preceding febrile illness prior to symptom onset, a pattern previously described in the literature, though its pathophysiological significance remains uncertain. Markedly reduced plasma riboflavin levels were documented in all three patients. Clinical exome sequencing identified a heterozygous missense mutation in exon 2 of the SLC52A3 gene (chr20:g.746030A>T, p.Met130Lys) in all three siblings — a single allelic heterozygous mutation, which is an atypical and rarely symptomatic genotype. This case series is significant as it highlights that heterozygous single allelic SLC52A3 mutations can produce significant clinical manifestations, expands the phenotypic spectrum of BVVL in an Indian familial context, and underscores the critical importance of early genetic diagnosis. All three patients were initiated on high-dose riboflavin supplementation (200 mg twice daily), with the eldest reporting meaningful functional improvement. This report reinforces that timely recognition and treatment of BVVL can substantially alter disease trajectory.
Farheen, Humaira; Omkar, Pratibha; Ahmed, Syed Faqeem; Begum, Vaseemunnisa; Sadiq, Neeraj; Krishna, Madhipati Sai; Subhani, Ghulam
Knowledge, attitude and practice of materiovigilance among healthcare professionals: A cross-sectional study Journal Article
In: Journal of Medical and Allied Sciences, vol. 16, iss. 2, pp. 79-84, 2026, ISSN: 2231-1696.
@article{Farheen_2026,
title = {Knowledge, attitude and practice of materiovigilance among healthcare professionals: A cross-sectional study},
author = {Humaira Farheen and Pratibha Omkar and Syed Faqeem Ahmed and Vaseemunnisa Begum and Neeraj Sadiq and Madhipati Sai Krishna and Ghulam Subhani},
url = {https://jmas.in/?mno=306744},
doi = {10.5455/jmas.306744},
issn = {2231-1696},
year = {2026},
date = {2026-07-31},
urldate = {2026-01-01},
journal = {Journal of Medical and Allied Sciences},
volume = {16},
issue = {2},
pages = {79-84},
publisher = {Deccan College of Medical Sciences},
abstract = {Materiovigilance is a systematic technique for detecting, gathering, reporting, and analyzing medical device-related adverse events to protect patient health by preventing recurrence. In order to ensure patient safety and improve device performance, it is crucial to identify gaps in current considerations and reporting processes. These experts' knowledge, attitude, and practice (KAP) are vital for effective adverse event reporting. The study's objective was to appraise health care workers' acquaintance and familiarity, attitude or approach, and practice or application (KAP) of materiovigilance. This was a cross-sectional, observational, questionnaire-based study conducted among MBBS students, postgraduate students, interns, pharmacy students, faculty members, technicians and nurses. The study was done between May 2024 and August 2024. A structured questionnaire in the English language was prepared, containing a total of 15 questions related to the knowledge (5 questions), attitude (4 questions) and practice (6 questions) aspects of materiovigilance. Statistical analysis was done using the R language. The questionnaire was distributed to 350 health professionals, out of whom 321 participated. Female contribution was more than that of males. The majority of healthcare personnel did not have sufficient knowledge; however, the majority of participants, 75%, believed that medical devices can cause adverse events. The results showed that healthcare authorities need to improve their skills in recognizing and comprehending persuasion and orientation for the application or practice of materiovigilance. The transition of medical device-related adverse events (MDAE) reporting was lacking among the study contributors, and more awareness programs and continuous professional development need to be addressed regularly.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Materiovigilance is a systematic technique for detecting, gathering, reporting, and analyzing medical device-related adverse events to protect patient health by preventing recurrence. In order to ensure patient safety and improve device performance, it is crucial to identify gaps in current considerations and reporting processes. These experts' knowledge, attitude, and practice (KAP) are vital for effective adverse event reporting. The study's objective was to appraise health care workers' acquaintance and familiarity, attitude or approach, and practice or application (KAP) of materiovigilance. This was a cross-sectional, observational, questionnaire-based study conducted among MBBS students, postgraduate students, interns, pharmacy students, faculty members, technicians and nurses. The study was done between May 2024 and August 2024. A structured questionnaire in the English language was prepared, containing a total of 15 questions related to the knowledge (5 questions), attitude (4 questions) and practice (6 questions) aspects of materiovigilance. Statistical analysis was done using the R language. The questionnaire was distributed to 350 health professionals, out of whom 321 participated. Female contribution was more than that of males. The majority of healthcare personnel did not have sufficient knowledge; however, the majority of participants, 75%, believed that medical devices can cause adverse events. The results showed that healthcare authorities need to improve their skills in recognizing and comprehending persuasion and orientation for the application or practice of materiovigilance. The transition of medical device-related adverse events (MDAE) reporting was lacking among the study contributors, and more awareness programs and continuous professional development need to be addressed regularly.
Kulkarni, Grishma; Mustafa, Maimoona
Cross-sectional study of the seroprevalence of HIV-2 in the tertiary care hospital at Hyderabad, India Journal Article
In: Journal of Medical and Allied Sciences, vol. 16, iss. 2, pp. 72-78, 2026, ISSN: 2231-1696.
@article{Kulkarni_2026,
title = {Cross-sectional study of the seroprevalence of HIV-2 in the tertiary care hospital at Hyderabad, India},
author = {Grishma Kulkarni and Maimoona Mustafa},
url = {https://jmas.in/index.php?mno=300265},
doi = {10.5455/jmas.300265},
issn = {2231-1696},
year = {2026},
date = {2026-07-31},
urldate = {2026-01-31},
journal = {Journal of Medical and Allied Sciences},
volume = {16},
issue = {2},
pages = {72-78},
publisher = {Deccan College of Medical Sciences},
abstract = {The HIV viruses,1 and 2 have approximately 40-60% identity at the amino acid level. The prevalence of HIV-2 remains highest among the West African countries and reports a prevalence of HIV-2 infection more than 1% in the general population. On the contrary, the prevalence of HIV-1 in India is high in comparison with HIV-2 because the rate of transmission of HIV-2 by heterosexual route, mother to child transmission and blood and blood products is very low. Also, the incubation period is longer for HIV-2 in comparison with HIV-1. Hence, a one-year cross-sectional study with retrospective data analysis for the duration from 01-Jan-2023 to 31-Dec-2023 was undertaken in a tertiary care hospital at Hyderabad to know the seroprevalence of HIV-2 in the patient population consisting of a total of 5759 serum specimens and were screened initially for the presence of p24 antigen of HIV-1 and antibodies against HIV-1 and -2 by rapid card test. Reactive samples for HIV-2 were further confirmed by the different rapid tests as per National Aids Control Organization (NACO). Reactivity for combined HIV-1 and -2 antibodies was seen in one in-patient (IP) sample whereas rest of the IP and all out-patient (OP) samples did not reveal any isolated reactivity for the presence of HIV-2 antibodies. So, HIV-2 reactivity only in IP samples was 0.021% whereas overall reactivity for HIV-2 antibodies was 0.017%. Though HIV-2 infection is very rare in India, the detection of it is very important from the management point of view.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The HIV viruses,1 and 2 have approximately 40-60% identity at the amino acid level. The prevalence of HIV-2 remains highest among the West African countries and reports a prevalence of HIV-2 infection more than 1% in the general population. On the contrary, the prevalence of HIV-1 in India is high in comparison with HIV-2 because the rate of transmission of HIV-2 by heterosexual route, mother to child transmission and blood and blood products is very low. Also, the incubation period is longer for HIV-2 in comparison with HIV-1. Hence, a one-year cross-sectional study with retrospective data analysis for the duration from 01-Jan-2023 to 31-Dec-2023 was undertaken in a tertiary care hospital at Hyderabad to know the seroprevalence of HIV-2 in the patient population consisting of a total of 5759 serum specimens and were screened initially for the presence of p24 antigen of HIV-1 and antibodies against HIV-1 and -2 by rapid card test. Reactive samples for HIV-2 were further confirmed by the different rapid tests as per National Aids Control Organization (NACO). Reactivity for combined HIV-1 and -2 antibodies was seen in one in-patient (IP) sample whereas rest of the IP and all out-patient (OP) samples did not reveal any isolated reactivity for the presence of HIV-2 antibodies. So, HIV-2 reactivity only in IP samples was 0.021% whereas overall reactivity for HIV-2 antibodies was 0.017%. Though HIV-2 infection is very rare in India, the detection of it is very important from the management point of view.
Aleem, Mohammed Abdul; Breik, Fahad Abdullah Bin; Hadi, Mohammed Abdul
In: Advances in Clinical Medical Research, vol. 7, iss. 2, pp. 380-388, 2026, ISSN: 2635-0815.
@article{Aleem_2026b,
title = {Role of the cell block technique in pulmonary cytology: enhancing diagnostic accuracy and molecular characterization of lung lesions-a systematic review and meta analysis},
author = {Mohammed Abdul Aleem and Fahad Abdullah Bin Breik and Mohammed Abdul Hadi },
url = {https://acmrjournal.com/index.php/ACMR/article/view/189/153},
issn = {2635-0815},
year = {2026},
date = {2026-06-26},
urldate = {2026-06-26},
journal = {Advances in Clinical Medical Research},
volume = {7},
issue = {2},
pages = {380-388},
abstract = {Background: Pulmonary cytology remains an indispensable diagnostic modality for evaluating lung lesions, particularly in patients undergoing minimally invasive procedures such as fine-needle aspiration cytology (FNAC), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), bronchial brushing, bronchoalveolar lavage (BAL), and pleural fluid cytology. However, conventional cytology smears often present limitations in architectural preservation, ancillary testing, and molecular characterization. The cell block (CB) technique has emerged as a valuable adjunct by providing histology-like sections suitable for immunohistochemistry (IHC) and molecular studies. This systematic review and meta-analysis evaluated the diagnostic and molecular utility of the cell block technique in pulmonary cytology. Materials and Methods: A systematic search of PubMed, Scopus, Web of Science, Embase, and Google Scholar was conducted for studies published between January 2000 and 2025. Eligible studies compared conventional cytology alone with cytology supplemented by cell block preparation in pulmonary specimens. Primary outcomes included diagnostic accuracy, sensitivity, specificity, and adequacy rates. Secondary outcomes included immunocytochemical utility and molecular testing success rates. A random-effects model was employed to calculate pooled effect estimates. Results: A total of 18 studies comprising 4,562 pulmonary specimens met the inclusion criteria. The pooled diagnostic accuracy increased from 78.4% with conventional cytology alone to 91.2% when supplemented with cell block preparation. Meta-analysis demonstrated a significant improvement in diagnostic yield (OR=2.89; 95% CI: 2.11–3.96; p<0.001). Cell block preparations significantly improved specimen adequacy for immunohistochemistry (89.5%) and molecular analysis (84.7%). Subgroup analysis showed superior performance in non-small cell lung carcinoma (NSCLC) characterization and EGFR, ALK, ROS1, and PD-L1 testing. Conclusion: The cell block technique substantially enhances diagnostic precision and molecular characterization in pulmonary cytology. Incorporation of cell block preparation into routine pulmonary cytology workflows is recommended, particularly in the era of precision oncology.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Pulmonary cytology remains an indispensable diagnostic modality for evaluating lung lesions, particularly in patients undergoing minimally invasive procedures such as fine-needle aspiration cytology (FNAC), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), bronchial brushing, bronchoalveolar lavage (BAL), and pleural fluid cytology. However, conventional cytology smears often present limitations in architectural preservation, ancillary testing, and molecular characterization. The cell block (CB) technique has emerged as a valuable adjunct by providing histology-like sections suitable for immunohistochemistry (IHC) and molecular studies. This systematic review and meta-analysis evaluated the diagnostic and molecular utility of the cell block technique in pulmonary cytology. Materials and Methods: A systematic search of PubMed, Scopus, Web of Science, Embase, and Google Scholar was conducted for studies published between January 2000 and 2025. Eligible studies compared conventional cytology alone with cytology supplemented by cell block preparation in pulmonary specimens. Primary outcomes included diagnostic accuracy, sensitivity, specificity, and adequacy rates. Secondary outcomes included immunocytochemical utility and molecular testing success rates. A random-effects model was employed to calculate pooled effect estimates. Results: A total of 18 studies comprising 4,562 pulmonary specimens met the inclusion criteria. The pooled diagnostic accuracy increased from 78.4% with conventional cytology alone to 91.2% when supplemented with cell block preparation. Meta-analysis demonstrated a significant improvement in diagnostic yield (OR=2.89; 95% CI: 2.11–3.96; p<0.001). Cell block preparations significantly improved specimen adequacy for immunohistochemistry (89.5%) and molecular analysis (84.7%). Subgroup analysis showed superior performance in non-small cell lung carcinoma (NSCLC) characterization and EGFR, ALK, ROS1, and PD-L1 testing. Conclusion: The cell block technique substantially enhances diagnostic precision and molecular characterization in pulmonary cytology. Incorporation of cell block preparation into routine pulmonary cytology workflows is recommended, particularly in the era of precision oncology.
Fareedullah, Mohammed; Ahmed, Mohammed Haseeb; Panga, Shanmuka Nagaraju; ur Rahman, Md Atiqh; Asra,; Fatima, Hasnat; Fatima, Zunera
In: International Journal of Pharmaceutical Sciences Review and Research, vol. 86, iss. 6, no. 01, pp. 1-11, 2026, ISSN: 0976-044X.
@article{Fareedullah_2026,
title = {Antimicrobial utilisation patterns, WHO Aware classification, and resistance profiles in a tertiary care critical care unit: a prospective observational study},
author = {Mohammed Fareedullah and Mohammed Haseeb Ahmed and Shanmuka Nagaraju Panga and Md Atiqh ur Rahman and Asra and Hasnat Fatima and Zunera Fatima },
url = {https://globalresearchonline.net/ijpsrr/v86-6/01.pdf},
doi = {10.47583/ijpsrr.2026.v86i06.001},
issn = {0976-044X},
year = {2026},
date = {2026-06-20},
urldate = {2026-06-20},
journal = {International Journal of Pharmaceutical Sciences Review and Research},
volume = {86},
number = {01},
issue = {6},
pages = {1-11},
abstract = {Background: Antimicrobial resistance (AMR) constitutes a critical patient safety threat in intensive care settings, where the convergence of severely ill patients, invasive devices, and extensive broad-spectrum antibiotic use creates conditions that selectively favour resistant pathogens. Systematic evaluation of prescribing patterns, resistance profiles, and alignment with stewardship frameworks is essential to guide rational antimicrobial use.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Antimicrobial resistance (AMR) constitutes a critical patient safety threat in intensive care settings, where the convergence of severely ill patients, invasive devices, and extensive broad-spectrum antibiotic use creates conditions that selectively favour resistant pathogens. Systematic evaluation of prescribing patterns, resistance profiles, and alignment with stewardship frameworks is essential to guide rational antimicrobial use.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.
Akram, Wasim; Arif, Ahlaam; Adil, Faraaz; Ali, Syed Zeeshan
Unmasking the causes of pediatric refractory status epilepticus: insights from three challenging cases Journal Article
In: Asian Journal of Case Reports in Medicine and Health, vol. 9, iss. 1, pp. 318-325, 2026.
@article{Akram_2026,
title = {Unmasking the causes of pediatric refractory status epilepticus: insights from three challenging cases},
author = {Wasim Akram and Ahlaam Arif and Faraaz Adil and Syed Zeeshan Ali},
url = {https://journalajcrmh.com/index.php/AJCRMH/article/view/332/800},
doi = {10.9734/ajcrmh/2026/v9i1332 },
year = {2026},
date = {2026-06-15},
urldate = {2026-06-15},
journal = {Asian Journal of Case Reports in Medicine and Health},
volume = {9},
issue = {1},
pages = {318-325},
abstract = {Status epilepticus (SE) refers to a neurological emergency where the condition can escalate even after treatment to refractory status epilepticus (RSE) with a high rate of both morbidity and mortality. According to the International League Against Epilepsy, seizures going beyond 5 minutes (t1) are more likely to persist, and those going beyond 30 minutes (t2) lead to irreversible neuronal injury. Case 1 was tuberculous meningoencephalitis with hydrocephalus, necessitating ventriculoperitoneal shunting. Case 2 was on the topic of highly resistant bacterial neonatal meningitis caused by Elizabethkingia meningoseptica. Case 3 was a study report on mtDNA depletion syndrome, which is a form of Alpers-Huttenlocher syndrome. Continuous midazolam infusion along with ventilatory support was the only way through which all the cases could be controlled from further seizure activity.
This study aims to investigate the causes of pediatric refractory status epilepticus and provide clinical insights through the presentation of three challenging cases.
This case series highlights that acute symptomatic etiologies, such as infections and metabolic disorders, are the main reasons behind pediatric RSE. It also emphasizes the importance of early neuroimaging, accelerated etiological diagnosis, and protocol-based EEG-guided anesthesia for achieving good neurological outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Status epilepticus (SE) refers to a neurological emergency where the condition can escalate even after treatment to refractory status epilepticus (RSE) with a high rate of both morbidity and mortality. According to the International League Against Epilepsy, seizures going beyond 5 minutes (t1) are more likely to persist, and those going beyond 30 minutes (t2) lead to irreversible neuronal injury. Case 1 was tuberculous meningoencephalitis with hydrocephalus, necessitating ventriculoperitoneal shunting. Case 2 was on the topic of highly resistant bacterial neonatal meningitis caused by Elizabethkingia meningoseptica. Case 3 was a study report on mtDNA depletion syndrome, which is a form of Alpers-Huttenlocher syndrome. Continuous midazolam infusion along with ventilatory support was the only way through which all the cases could be controlled from further seizure activity.
This study aims to investigate the causes of pediatric refractory status epilepticus and provide clinical insights through the presentation of three challenging cases.
This case series highlights that acute symptomatic etiologies, such as infections and metabolic disorders, are the main reasons behind pediatric RSE. It also emphasizes the importance of early neuroimaging, accelerated etiological diagnosis, and protocol-based EEG-guided anesthesia for achieving good neurological outcomes.
This study aims to investigate the causes of pediatric refractory status epilepticus and provide clinical insights through the presentation of three challenging cases.
This case series highlights that acute symptomatic etiologies, such as infections and metabolic disorders, are the main reasons behind pediatric RSE. It also emphasizes the importance of early neuroimaging, accelerated etiological diagnosis, and protocol-based EEG-guided anesthesia for achieving good neurological outcomes.
Aleem, Mohammed Abdul; Breik, Fahad Abdullah Bin; and Mohammed Abdul Muqeeth,
In: International Journal of Medicine, vol. 8, iss. 6, pp. 408-420, 2026, ISSN: 1468-3814.
@article{Aleem_2026,
title = {Artificial intelligence-based prediction of EGFR, ALK, and KRAS oncogenic mutations from histopathological whole-slide images in lung carcinoma: a systematic review and meta-analysis},
author = {Mohammed Abdul Aleem and Fahad Abdullah Bin Breik and and Mohammed Abdul Muqeeth},
url = {https://app.theinternationalmedicine.com/public/testarticle/pdfFile-1781176241094-78577456.pdf},
doi = {10.61336/im/26-06-62},
issn = {1468-3814},
year = {2026},
date = {2026-06-11},
urldate = {2026-06-11},
journal = {International Journal of Medicine},
volume = {8},
issue = {6},
pages = {408-420},
abstract = {Background: The accurate identification of actionable oncogenic driver mutations—epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral proto-oncogene (KRAS)—is indispensable for precision oncology in non-small cell lung carcinoma (NSCLC). Conventional molecular testing remains costly, tissue-consumptive, and inaccessible in resource-limited settings. Artificial intelligence (AI) applied to routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) represents a transformative paradigm for non-invasive genomic inference. This meta-analysis provides the first comprehensive quantitative synthesis of diagnostic accuracy for AI-based mutation prediction from lung histopathology. Methods: A systematic search of PubMed, MEDLINE, Scopus, Web of Science, and EMBASE was conducted from January 2015 to December 2024, following PRISMA 2020 guidelines. Studies employing any AI or machine learning methodology to predict EGFR, ALK, or KRAS mutational status from digitised lung histopathology slides were eligible. Bivariate random-effects modelling was used to pool diagnostic accuracy metrics. Heterogeneity was evaluated using the I² statistic and Cochran's Q test. Quality appraisal was performed using QUADAS-2. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Results: Forty-three studies (n = 28,614 specimens) met inclusion criteria. Pooled area under the receiver operating characteristic curve (AUC) was 0.821 (95% CI: 0.804–0.839) for EGFR, 0.851 (95% CI: 0.829–0.873) for ALK, and 0.741 (95% CI: 0.712–0.770) for KRAS prediction. Sensitivity and specificity were highest for ALK (78.6% and 80.4%, respectively). Substantial heterogeneity was observed (I²: 61–80%). Transformer-based architectures and foundation models yielded superior performance over conventional CNNs (AUC 0.871 vs. 0.808, p < 0.001). Multi-institutional external validation significantly reduced overfitting bias. Conclusion: AI-based histopathological analysis demonstrates clinically meaningful diagnostic accuracy for EGFR and ALK mutation prediction, approaching levels sufficient for triage-level clinical utility. KRAS prediction performance remains suboptimal. Standardisation of cohort assembly, validation protocols, and reporting frameworks is essential before clinical deployment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: The accurate identification of actionable oncogenic driver mutations—epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral proto-oncogene (KRAS)—is indispensable for precision oncology in non-small cell lung carcinoma (NSCLC). Conventional molecular testing remains costly, tissue-consumptive, and inaccessible in resource-limited settings. Artificial intelligence (AI) applied to routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) represents a transformative paradigm for non-invasive genomic inference. This meta-analysis provides the first comprehensive quantitative synthesis of diagnostic accuracy for AI-based mutation prediction from lung histopathology. Methods: A systematic search of PubMed, MEDLINE, Scopus, Web of Science, and EMBASE was conducted from January 2015 to December 2024, following PRISMA 2020 guidelines. Studies employing any AI or machine learning methodology to predict EGFR, ALK, or KRAS mutational status from digitised lung histopathology slides were eligible. Bivariate random-effects modelling was used to pool diagnostic accuracy metrics. Heterogeneity was evaluated using the I² statistic and Cochran's Q test. Quality appraisal was performed using QUADAS-2. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Results: Forty-three studies (n = 28,614 specimens) met inclusion criteria. Pooled area under the receiver operating characteristic curve (AUC) was 0.821 (95% CI: 0.804–0.839) for EGFR, 0.851 (95% CI: 0.829–0.873) for ALK, and 0.741 (95% CI: 0.712–0.770) for KRAS prediction. Sensitivity and specificity were highest for ALK (78.6% and 80.4%, respectively). Substantial heterogeneity was observed (I²: 61–80%). Transformer-based architectures and foundation models yielded superior performance over conventional CNNs (AUC 0.871 vs. 0.808, p < 0.001). Multi-institutional external validation significantly reduced overfitting bias. Conclusion: AI-based histopathological analysis demonstrates clinically meaningful diagnostic accuracy for EGFR and ALK mutation prediction, approaching levels sufficient for triage-level clinical utility. KRAS prediction performance remains suboptimal. Standardisation of cohort assembly, validation protocols, and reporting frameworks is essential before clinical deployment.
Siddiqua, Arshiya; Anupama, Swarna; Reddy, Ramakanth; Jagadeesh, Chittuluri
Role of serum D-dimer in early prediction of organ failure in acute pancreatitis: a retrospective study Journal Article
In: International Journal of Pharmaceutical and Biological Research , vol. 14, iss. 2, pp. 206-211, 2026, ISSN: 2320-9267.
@article{Siddiqua_2026,
title = {Role of serum D-dimer in early prediction of organ failure in acute pancreatitis: a retrospective study},
author = {Arshiya Siddiqua and Swarna Anupama and Ramakanth Reddy and Chittuluri Jagadeesh},
url = {https://ijpbr.in/index.php/IJPBR/article/view/1222/753},
doi = {10.30750/ijpbr.14.2.36 },
issn = {2320-9267},
year = {2026},
date = {2026-06-09},
urldate = {2026-06-09},
journal = {International Journal of Pharmaceutical and Biological Research },
volume = {14},
issue = {2},
pages = {206-211},
abstract = {Background: Acute pancreatitis (AP) is a common gastrointestinal emergency with clinical outcomes ranging from mild self-limiting disease to severe systemic inflammation and multi-organ dysfunction. Early identification of patients at risk of organ failure remains essential for timely intervention. Serum D-dimer, a degradation product of cross-linked fibrin, has emerged as a potential biomarker reflecting activation of coagulation and inflammatory pathways.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Acute pancreatitis (AP) is a common gastrointestinal emergency with clinical outcomes ranging from mild self-limiting disease to severe systemic inflammation and multi-organ dysfunction. Early identification of patients at risk of organ failure remains essential for timely intervention. Serum D-dimer, a degradation product of cross-linked fibrin, has emerged as a potential biomarker reflecting activation of coagulation and inflammatory pathways.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.
Banerjee, Preeti; Sahu, Pooja; Naaz, Zoya; Mahmood, Aneesa; Begum, Nazma; Rao, Chowdavarapu R.
Posterior reversible encephalopathy syndrome in eclampsia: a prospective study of risk factors and outcomes Journal Article
In: Cureus, vol. 18, iss. 6, pp. e110179, 2026, ISSN: 2168-8184.
@article{Banerjee_2026,
title = {Posterior reversible encephalopathy syndrome in eclampsia: a prospective study of risk factors and outcomes},
author = {Preeti Banerjee and Pooja Sahu and Zoya Naaz and Aneesa Mahmood and Nazma Begum and Chowdavarapu R. Rao},
url = {https://www.cureus.com/articles/494595-posterior-reversible-encephalopathy-syndrome-in-eclampsia-a-prospective-study-of-risk-factors-and-outcomes#!/},
doi = {10.7759/cureus.110179},
issn = {2168-8184},
year = {2026},
date = {2026-06-03},
urldate = {2026-03-06},
journal = {Cureus},
volume = {18},
issue = {6},
pages = {e110179},
abstract = {Introduction: Posterior reversible encephalopathy syndrome is an important neurological complication associated with eclampsia that contributes significantly to maternal and perinatal morbidity in high-risk pregnancies. This study aimed to determine the prevalence of posterior reversible encephalopathy syndrome in women with eclampsia and to evaluate the associated risk factors, radiological findings, and maternal and perinatal outcomes.
Materials and methods: This prospective observational study was conducted at a tertiary care teaching hospital in Hyderabad, India, between January 2022 and December 2024. In total, 140 women with eclampsia were enrolled in this study. The diagnosis of posterior reversible encephalopathy syndrome was confirmed using magnetic resonance imaging performed within 48-72 hours of admission. Clinical, laboratory, and imaging data were recorded. Statistical analysis was performed using SPSS Statistics (version 26.0; IBM Inc., Armonk, New York, United States). Continuous variables were compared using the independent samples t-test or Mann-Whitney U test, and categorical variables were compared using the chi-square test or Fisher's exact test. Logistic regression analysis was used to identify the independent predictors.
Results: Posterior reversible encephalopathy syndrome was observed in 62 (44.3%) women. The syndrome was associated with higher systolic blood pressure (178.4 ± 18.6 vs. 162.3 ± 16.2 mmHg; p < 0.001), higher frequency of three or more convulsions (p < 0.001), delayed treatment (p = 0.002), thrombocytopenia, and elevated serum creatinine (p < 0.001). The independent predictors included systolic blood pressure of 170 mmHg or more (adjusted odds ratio 3.21; p = 0.003), three or more convulsions (adjusted odds ratio 3.68; p < 0.001), delayed treatment (adjusted odds ratio 2.54; p = 0.017), platelet count less than 100 × 10³ per microliter (adjusted odds ratio 2.24; p = 0.044), and serum creatinine of 1.2 mg/dL or more (adjusted odds ratio 2.86; p = 0.008). Maternal complications, including intensive care unit admission (p < 0.001) and acute kidney injury (p < 0.001), were higher in the posterior reversible encephalopathy syndrome group. Neonatal outcomes were also worse, with higher rates of low birth weight (p = 0.001) and preterm birth (p < 0.001).
Conclusion:Posterior reversible encephalopathy syndrome is a frequent complication of eclampsia and is associated with a severe clinical presentation and adverse maternal and neonatal outcomes. Early identification and timely management of high-risk patients are essential for improving prognosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Posterior reversible encephalopathy syndrome is an important neurological complication associated with eclampsia that contributes significantly to maternal and perinatal morbidity in high-risk pregnancies. This study aimed to determine the prevalence of posterior reversible encephalopathy syndrome in women with eclampsia and to evaluate the associated risk factors, radiological findings, and maternal and perinatal outcomes.
Materials and methods: This prospective observational study was conducted at a tertiary care teaching hospital in Hyderabad, India, between January 2022 and December 2024. In total, 140 women with eclampsia were enrolled in this study. The diagnosis of posterior reversible encephalopathy syndrome was confirmed using magnetic resonance imaging performed within 48-72 hours of admission. Clinical, laboratory, and imaging data were recorded. Statistical analysis was performed using SPSS Statistics (version 26.0; IBM Inc., Armonk, New York, United States). Continuous variables were compared using the independent samples t-test or Mann-Whitney U test, and categorical variables were compared using the chi-square test or Fisher's exact test. Logistic regression analysis was used to identify the independent predictors.
Results: Posterior reversible encephalopathy syndrome was observed in 62 (44.3%) women. The syndrome was associated with higher systolic blood pressure (178.4 ± 18.6 vs. 162.3 ± 16.2 mmHg; p < 0.001), higher frequency of three or more convulsions (p < 0.001), delayed treatment (p = 0.002), thrombocytopenia, and elevated serum creatinine (p < 0.001). The independent predictors included systolic blood pressure of 170 mmHg or more (adjusted odds ratio 3.21; p = 0.003), three or more convulsions (adjusted odds ratio 3.68; p < 0.001), delayed treatment (adjusted odds ratio 2.54; p = 0.017), platelet count less than 100 × 10³ per microliter (adjusted odds ratio 2.24; p = 0.044), and serum creatinine of 1.2 mg/dL or more (adjusted odds ratio 2.86; p = 0.008). Maternal complications, including intensive care unit admission (p < 0.001) and acute kidney injury (p < 0.001), were higher in the posterior reversible encephalopathy syndrome group. Neonatal outcomes were also worse, with higher rates of low birth weight (p = 0.001) and preterm birth (p < 0.001).
Conclusion:Posterior reversible encephalopathy syndrome is a frequent complication of eclampsia and is associated with a severe clinical presentation and adverse maternal and neonatal outcomes. Early identification and timely management of high-risk patients are essential for improving prognosis.
Materials and methods: This prospective observational study was conducted at a tertiary care teaching hospital in Hyderabad, India, between January 2022 and December 2024. In total, 140 women with eclampsia were enrolled in this study. The diagnosis of posterior reversible encephalopathy syndrome was confirmed using magnetic resonance imaging performed within 48-72 hours of admission. Clinical, laboratory, and imaging data were recorded. Statistical analysis was performed using SPSS Statistics (version 26.0; IBM Inc., Armonk, New York, United States). Continuous variables were compared using the independent samples t-test or Mann-Whitney U test, and categorical variables were compared using the chi-square test or Fisher's exact test. Logistic regression analysis was used to identify the independent predictors.
Results: Posterior reversible encephalopathy syndrome was observed in 62 (44.3%) women. The syndrome was associated with higher systolic blood pressure (178.4 ± 18.6 vs. 162.3 ± 16.2 mmHg; p < 0.001), higher frequency of three or more convulsions (p < 0.001), delayed treatment (p = 0.002), thrombocytopenia, and elevated serum creatinine (p < 0.001). The independent predictors included systolic blood pressure of 170 mmHg or more (adjusted odds ratio 3.21; p = 0.003), three or more convulsions (adjusted odds ratio 3.68; p < 0.001), delayed treatment (adjusted odds ratio 2.54; p = 0.017), platelet count less than 100 × 10³ per microliter (adjusted odds ratio 2.24; p = 0.044), and serum creatinine of 1.2 mg/dL or more (adjusted odds ratio 2.86; p = 0.008). Maternal complications, including intensive care unit admission (p < 0.001) and acute kidney injury (p < 0.001), were higher in the posterior reversible encephalopathy syndrome group. Neonatal outcomes were also worse, with higher rates of low birth weight (p = 0.001) and preterm birth (p < 0.001).
Conclusion:Posterior reversible encephalopathy syndrome is a frequent complication of eclampsia and is associated with a severe clinical presentation and adverse maternal and neonatal outcomes. Early identification and timely management of high-risk patients are essential for improving prognosis.
Banerjee, Preeti; Sgouraki, Maria; Nayak, Subhashree; Tiwari, Heena; Kalsi, Jasmine; Syed, Afroz K.
Predictors of postpartum haemorrhage following repeat caesarean section: a retrospective cohort study Journal Article
In: Cureus, vol. 18, iss. 5, pp. e109926, 2026, ISSN: 2168-8184.
@article{Banerjee_2026b,
title = {Predictors of postpartum haemorrhage following repeat caesarean section: a retrospective cohort study},
author = {Preeti Banerjee and Maria Sgouraki and Subhashree Nayak and Heena Tiwari and Jasmine Kalsi and Afroz K. Syed},
url = {https://assets.cureus.com/uploads/original_article/pdf/496555/20260629-301937-rkycty.pdf},
doi = {10.7759/cureus.109926},
issn = {2168-8184},
year = {2026},
date = {2026-05-30},
urldate = {2026-05-30},
journal = {Cureus},
volume = {18},
issue = {5},
pages = {e109926},
abstract = {Introduction: Postpartum hemorrhage (PPH) is a major obstetric emergency that contributes substantially to maternal morbidity following cesarean delivery. The identification of high-risk patients undergoing repeat cesarean sections may help improve perioperative preparedness and maternal outcomes. The present study aimed to identify predictors of PPH following repeated cesarean sections.
Materials and methods: A retrospective cohort study was conducted in the Department of Obstetrics and Gynecology on 200 women who underwent repeat cesarean section between January 2020 and December 2025. Demographic, obstetric, and intraoperative data were retrieved from archived medical records. PPH was defined as blood loss ≥1000 mL during or within 24 hours after cesarean delivery or the requirement for transfusion/intervention. Statistical analysis was performed using univariate analysis and multivariable logistic regression to identify independent predictors of PPH. Adjusted odds ratios (aORs) with 95% confidence intervals were calculated, and a p-value < 0.05 was considered statistically significant.
Results: Among the 200 patients, PPH was observed in 72 (36.0%), while 128 (64.0%) did not develop hemorrhage. Women with PPH demonstrated significantly higher body mass index (BMI) (28.3 ± 3.9 kg/m² vs. 25.9 ± 3.3 kg/m²), a greater number of previous cesarean sections (2.1 ± 0.8 vs. 1.6 ± 0.6), lower antenatal hemoglobin levels (9.6 ± 1.4 g/dL vs. 10.7 ± 1.4 g/dL), and prolonged surgery duration (74.8 ± 19.6 min vs. 55.2 ± 14.3 min) (p < 0.001). Placenta previa or placental abnormalities, intraoperative adhesions, and emergency cesarean sections were significantly associated with hemorrhage. Multivariable logistic regression identified placenta previa or placental abnormality (aOR = 3.33), intraoperative adhesions (aOR = 2.50), ≥3 previous cesarean sections (aOR = 2.00), emergency cesarean section (aOR = 1.80), higher parity, elevated BMI, prolonged surgery duration, and lower antenatal hemoglobin level as independent predictors of PPH (all p < 0.05).
Conclusion: PPH following repeated cesarean sections is strongly associated with multiple maternal and intraoperative risk factors. Early identification of high-risk patients may facilitate improved surgical planning, preventive interventions, and optimized maternal care. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Postpartum hemorrhage (PPH) is a major obstetric emergency that contributes substantially to maternal morbidity following cesarean delivery. The identification of high-risk patients undergoing repeat cesarean sections may help improve perioperative preparedness and maternal outcomes. The present study aimed to identify predictors of PPH following repeated cesarean sections.
Materials and methods: A retrospective cohort study was conducted in the Department of Obstetrics and Gynecology on 200 women who underwent repeat cesarean section between January 2020 and December 2025. Demographic, obstetric, and intraoperative data were retrieved from archived medical records. PPH was defined as blood loss ≥1000 mL during or within 24 hours after cesarean delivery or the requirement for transfusion/intervention. Statistical analysis was performed using univariate analysis and multivariable logistic regression to identify independent predictors of PPH. Adjusted odds ratios (aORs) with 95% confidence intervals were calculated, and a p-value < 0.05 was considered statistically significant.
Results: Among the 200 patients, PPH was observed in 72 (36.0%), while 128 (64.0%) did not develop hemorrhage. Women with PPH demonstrated significantly higher body mass index (BMI) (28.3 ± 3.9 kg/m² vs. 25.9 ± 3.3 kg/m²), a greater number of previous cesarean sections (2.1 ± 0.8 vs. 1.6 ± 0.6), lower antenatal hemoglobin levels (9.6 ± 1.4 g/dL vs. 10.7 ± 1.4 g/dL), and prolonged surgery duration (74.8 ± 19.6 min vs. 55.2 ± 14.3 min) (p < 0.001). Placenta previa or placental abnormalities, intraoperative adhesions, and emergency cesarean sections were significantly associated with hemorrhage. Multivariable logistic regression identified placenta previa or placental abnormality (aOR = 3.33), intraoperative adhesions (aOR = 2.50), ≥3 previous cesarean sections (aOR = 2.00), emergency cesarean section (aOR = 1.80), higher parity, elevated BMI, prolonged surgery duration, and lower antenatal hemoglobin level as independent predictors of PPH (all p < 0.05).
Conclusion: PPH following repeated cesarean sections is strongly associated with multiple maternal and intraoperative risk factors. Early identification of high-risk patients may facilitate improved surgical planning, preventive interventions, and optimized maternal care.
Materials and methods: A retrospective cohort study was conducted in the Department of Obstetrics and Gynecology on 200 women who underwent repeat cesarean section between January 2020 and December 2025. Demographic, obstetric, and intraoperative data were retrieved from archived medical records. PPH was defined as blood loss ≥1000 mL during or within 24 hours after cesarean delivery or the requirement for transfusion/intervention. Statistical analysis was performed using univariate analysis and multivariable logistic regression to identify independent predictors of PPH. Adjusted odds ratios (aORs) with 95% confidence intervals were calculated, and a p-value < 0.05 was considered statistically significant.
Results: Among the 200 patients, PPH was observed in 72 (36.0%), while 128 (64.0%) did not develop hemorrhage. Women with PPH demonstrated significantly higher body mass index (BMI) (28.3 ± 3.9 kg/m² vs. 25.9 ± 3.3 kg/m²), a greater number of previous cesarean sections (2.1 ± 0.8 vs. 1.6 ± 0.6), lower antenatal hemoglobin levels (9.6 ± 1.4 g/dL vs. 10.7 ± 1.4 g/dL), and prolonged surgery duration (74.8 ± 19.6 min vs. 55.2 ± 14.3 min) (p < 0.001). Placenta previa or placental abnormalities, intraoperative adhesions, and emergency cesarean sections were significantly associated with hemorrhage. Multivariable logistic regression identified placenta previa or placental abnormality (aOR = 3.33), intraoperative adhesions (aOR = 2.50), ≥3 previous cesarean sections (aOR = 2.00), emergency cesarean section (aOR = 1.80), higher parity, elevated BMI, prolonged surgery duration, and lower antenatal hemoglobin level as independent predictors of PPH (all p < 0.05).
Conclusion: PPH following repeated cesarean sections is strongly associated with multiple maternal and intraoperative risk factors. Early identification of high-risk patients may facilitate improved surgical planning, preventive interventions, and optimized maternal care.
Adil, Mohammed Abdul Majid; Raj, Yeershetty Goutham; Begum, Rabiya
Diagnostic yield of urine cytology compared with cystoscopy in bladder cancer follow-up Journal Article
In: European Journal of Clinical Pharmacy, vol. 8, iss. 1, pp. 3298-3301, 2026, ISSN: 2385-409X.
@article{Adil_2026,
title = {Diagnostic yield of urine cytology compared with cystoscopy in bladder cancer follow-up},
author = {Mohammed Abdul Majid Adil and Yeershetty Goutham Raj and Rabiya Begum},
url = {http://files.farmclin.com/testarticle/1779442159744-EMRN4180.pdf},
doi = {10.61336/ejcp/26-08-410},
issn = {2385-409X},
year = {2026},
date = {2026-05-21},
urldate = {2026-05-21},
journal = {European Journal of Clinical Pharmacy},
volume = {8},
issue = {1},
pages = {3298-3301},
abstract = {Bladder cancer is characterized by high recurrence rates, necessitating rigorous follow-up. Cystoscopy remains the gold standard, while urine cytology offers a non-invasive alternative. However, their comparative diagnostic utility remains debated.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bladder cancer is characterized by high recurrence rates, necessitating rigorous follow-up. Cystoscopy remains the gold standard, while urine cytology offers a non-invasive alternative. However, their comparative diagnostic utility remains debated.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.
Sultana, Zareena; Tahseen, Surayya; Safiya, Amtul Aziz; Syed, Urooj; Mateen, Mariam Amtul; Amara, Umme
Serum uric acid as predictor of adverse perinatal outcome of pre-eclampsia Journal Article
In: International Journal of Medicine and Public Health, vol. 16, iss. 2, pp. 1735-1741, 2026, ISSN: 2230-8598.
@article{Sultana_2026b,
title = {Serum uric acid as predictor of adverse perinatal outcome of pre-eclampsia},
author = {Zareena Sultana and Surayya Tahseen and Amtul Aziz Safiya and Urooj Syed and Mariam Amtul Mateen and Umme Amara},
url = {https://www.ijmedph.org/Uploads/Volume16Issue2/288_5118_IJMEDPH_Jafar_1735_1741.pdf},
doi = {10.70034/ijmedph.2026.2.288},
issn = {2230-8598},
year = {2026},
date = {2026-04-30},
urldate = {2026-04-30},
journal = {International Journal of Medicine and Public Health},
volume = {16},
issue = {2},
pages = {1735-1741},
abstract = {Background: The aim is to study serum uric acid in cases of preeclampsia and its effect on pregnancy outcome.
Materials and Methods: A prospective observational study to estimate serum uric acid was carried out in 100 pregnant women admitted in Deccan College of Medical Sciences during the period of September 2024 – September 2025 with diagnosis of pre-eclampsia (pregnancy induced hypertension and proteinuria with or without pathological edema). According to WHO, the prevalence of pre-eclampsia in developing countries is 2-15%. These patients were included in the study after due informed consent.
Results: In the present study, distribution according to the age of mothers: 36% of mothers were between the age group 18-21 years, 22% were between 22-25 years,16% were between 26-29 years, and 26% were above 30 years. The study showed 60.0% of mothers were primi, 28.0% were second gravid, 8.0% were third gravid and 4% were fourth gravid. In the present study, Urine albumin was 1+ in 17% of mothers, 2+ in 49% of mothers, 3+ in 34 % of mothers. 17 out of 32 women with serum uric acid ≥6mg/dl had maternal complications and 27 out of 68women with serum uric acid <6mg/dl had maternal complications with a statistically non-significant p value of 0.4. 1% of mothers developed HELLP, 7% of mothers developed Ascites, 16% of mothers developed Eclampsia and 20% of mothers developed Abruption. Final results indicate that Serum uric acid has not significantly contributed for predicting the maternal outcome.
Conclusion: The present study concluded that the implementation of serum uric acid in predictive models in combination with established biomarkers could help determine its potential additive value in the prediction of the disease as well as the severity of accompanying complications. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: The aim is to study serum uric acid in cases of preeclampsia and its effect on pregnancy outcome.
Materials and Methods: A prospective observational study to estimate serum uric acid was carried out in 100 pregnant women admitted in Deccan College of Medical Sciences during the period of September 2024 – September 2025 with diagnosis of pre-eclampsia (pregnancy induced hypertension and proteinuria with or without pathological edema). According to WHO, the prevalence of pre-eclampsia in developing countries is 2-15%. These patients were included in the study after due informed consent.
Results: In the present study, distribution according to the age of mothers: 36% of mothers were between the age group 18-21 years, 22% were between 22-25 years,16% were between 26-29 years, and 26% were above 30 years. The study showed 60.0% of mothers were primi, 28.0% were second gravid, 8.0% were third gravid and 4% were fourth gravid. In the present study, Urine albumin was 1+ in 17% of mothers, 2+ in 49% of mothers, 3+ in 34 % of mothers. 17 out of 32 women with serum uric acid ≥6mg/dl had maternal complications and 27 out of 68women with serum uric acid <6mg/dl had maternal complications with a statistically non-significant p value of 0.4. 1% of mothers developed HELLP, 7% of mothers developed Ascites, 16% of mothers developed Eclampsia and 20% of mothers developed Abruption. Final results indicate that Serum uric acid has not significantly contributed for predicting the maternal outcome.
Conclusion: The present study concluded that the implementation of serum uric acid in predictive models in combination with established biomarkers could help determine its potential additive value in the prediction of the disease as well as the severity of accompanying complications.
Materials and Methods: A prospective observational study to estimate serum uric acid was carried out in 100 pregnant women admitted in Deccan College of Medical Sciences during the period of September 2024 – September 2025 with diagnosis of pre-eclampsia (pregnancy induced hypertension and proteinuria with or without pathological edema). According to WHO, the prevalence of pre-eclampsia in developing countries is 2-15%. These patients were included in the study after due informed consent.
Results: In the present study, distribution according to the age of mothers: 36% of mothers were between the age group 18-21 years, 22% were between 22-25 years,16% were between 26-29 years, and 26% were above 30 years. The study showed 60.0% of mothers were primi, 28.0% were second gravid, 8.0% were third gravid and 4% were fourth gravid. In the present study, Urine albumin was 1+ in 17% of mothers, 2+ in 49% of mothers, 3+ in 34 % of mothers. 17 out of 32 women with serum uric acid ≥6mg/dl had maternal complications and 27 out of 68women with serum uric acid <6mg/dl had maternal complications with a statistically non-significant p value of 0.4. 1% of mothers developed HELLP, 7% of mothers developed Ascites, 16% of mothers developed Eclampsia and 20% of mothers developed Abruption. Final results indicate that Serum uric acid has not significantly contributed for predicting the maternal outcome.
Conclusion: The present study concluded that the implementation of serum uric acid in predictive models in combination with established biomarkers could help determine its potential additive value in the prediction of the disease as well as the severity of accompanying complications.
Saleem, Zafar Sultana Abdul; Hussain, Murtaza; Kausar, Syeda Tasneem; Begum, Meherunnisa; Fatima, Afroze; Fatima, Munawar; Saheb, Shaik Hussain
Medical students perception of the anatomage virtual dissection table as a learning tool in anatomy education Journal Article
In: Acta Medica International, vol. 13, iss. 1, pp. 1160-1166, 2026, ISSN: 2349-0578.
@article{Sultana_2026,
title = {Medical students perception of the anatomage virtual dissection table as a learning tool in anatomy education},
author = {Zafar Sultana Abdul Saleem and Murtaza Hussain and Syeda Tasneem Kausar and Meherunnisa Begum and Afroze Fatima and Munawar Fatima and Shaik Hussain Saheb},
url = {https://www.parsvnath.in/journals/acta-medica-international/articles/medical-students-perception-of-the-anatomage-virtual-dissection-table-as-a-learning-tool-in-anatomy-education},
doi = {10.21276/amit.2026.v13.i1.618},
issn = {2349-0578},
year = {2026},
date = {2026-04-28},
urldate = {2026-04-28},
journal = {Acta Medica International},
volume = {13},
issue = {1},
pages = {1160-1166},
abstract = {Background: Integration of technology-enabled learning tools in medical education has gained momentum globally. The Anatomage table, a three-dimensional virtual dissection platform, represents an innovative supplement to traditional anatomy teaching methods. However, empirical data on undergraduate students' perceptions of this technology as a pedagogical tool remain limited in the Indian medical education context. The objective is to assess Phase-I medical students' perceptions regarding the Anatomage virtual dissection table as an adjunctive learning tool in anatomy education and to determine their preferences regarding combined versus traditional teaching methodologies. Material and Methods: This was a cross-sectional, institutional survey-based study conducted after obtaining Institutional Ethics Committee clearance. A structured questionnaire with 22 items using a 5-point Likert scale (1=Strongly Disagree to 5=Strongly Agree) was administered to Phase-I MBBS students through Google Forms. The survey assessed students' perceptions on: (1) learning experience and engagement with Anatomage, (2) comprehension of anatomical concepts and relations, (3) comparative effectiveness with cadaveric dissection, (4) retention and stress reduction, and (5) optimal curriculum integration strategies. Responses were analysed using Microsoft Excel with descriptive statistics. Results: Of 150 students invited, 136 responded (response rate: 90.67%). Demographic data included a mean age of 19.5 years (SD=1.2), 47 male students, and 89 female students. Key findings: (1) 64.7% (n=88) of students preferred learning through cadaveric dissection exclusively; (2) 44.9% (n=61) agreed that Anatomage sessions facilitated deeper understanding of subject matter; (3) 69.9% (n=95) expressed that Anatomage cannot replace cadaveric dissection; (4) 88.2% (n=120) strongly endorsed integration of both Anatomage sessions and cadaveric dissection in the regular curriculum; (5) Students reported enhanced visualisation of complex anatomical relations, improved concept clarity over rote memorisation, and reduced learning-related stress with Anatomage supplementation. Conclusion: The Anatomage virtual dissection table demonstrates significant potential as a gold-standard adjunctive learning tool in undergraduate anatomy education. Rather than serving as a replacement for cadaveric dissection, it functions optimally as a complementary modality addressing cadaver scarcity while enhancing pedagogical effectiveness. Integration of technology-based learning with traditional dissection methods aligns with student preferences and contemporary medical education standards. Institutional implementation should include scheduled individual and small-group hands-on Anatomage sessions integrated with cadaveric dissection to optimise learning outcomes and student satisfaction.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Integration of technology-enabled learning tools in medical education has gained momentum globally. The Anatomage table, a three-dimensional virtual dissection platform, represents an innovative supplement to traditional anatomy teaching methods. However, empirical data on undergraduate students' perceptions of this technology as a pedagogical tool remain limited in the Indian medical education context. The objective is to assess Phase-I medical students' perceptions regarding the Anatomage virtual dissection table as an adjunctive learning tool in anatomy education and to determine their preferences regarding combined versus traditional teaching methodologies. Material and Methods: This was a cross-sectional, institutional survey-based study conducted after obtaining Institutional Ethics Committee clearance. A structured questionnaire with 22 items using a 5-point Likert scale (1=Strongly Disagree to 5=Strongly Agree) was administered to Phase-I MBBS students through Google Forms. The survey assessed students' perceptions on: (1) learning experience and engagement with Anatomage, (2) comprehension of anatomical concepts and relations, (3) comparative effectiveness with cadaveric dissection, (4) retention and stress reduction, and (5) optimal curriculum integration strategies. Responses were analysed using Microsoft Excel with descriptive statistics. Results: Of 150 students invited, 136 responded (response rate: 90.67%). Demographic data included a mean age of 19.5 years (SD=1.2), 47 male students, and 89 female students. Key findings: (1) 64.7% (n=88) of students preferred learning through cadaveric dissection exclusively; (2) 44.9% (n=61) agreed that Anatomage sessions facilitated deeper understanding of subject matter; (3) 69.9% (n=95) expressed that Anatomage cannot replace cadaveric dissection; (4) 88.2% (n=120) strongly endorsed integration of both Anatomage sessions and cadaveric dissection in the regular curriculum; (5) Students reported enhanced visualisation of complex anatomical relations, improved concept clarity over rote memorisation, and reduced learning-related stress with Anatomage supplementation. Conclusion: The Anatomage virtual dissection table demonstrates significant potential as a gold-standard adjunctive learning tool in undergraduate anatomy education. Rather than serving as a replacement for cadaveric dissection, it functions optimally as a complementary modality addressing cadaver scarcity while enhancing pedagogical effectiveness. Integration of technology-based learning with traditional dissection methods aligns with student preferences and contemporary medical education standards. Institutional implementation should include scheduled individual and small-group hands-on Anatomage sessions integrated with cadaveric dissection to optimise learning outcomes and student satisfaction.
Raj, Yeershetty Goutham; Adil, Mohammed Abdul Majid; Goud, P. Umesh Chandran
In: CME Journal of Geriatric Medicine, vol. 18, iss. 4, pp. 271-274, 2026, ISSN: 1475-1453.
@article{Raj_2026,
title = {Assessment of intravesical prostatic protrusion and its association with severity of lower urinary tract symptoms in benign prostatic hyperplasia: a prospective observational study},
author = {Yeershetty Goutham Raj and Mohammed Abdul Majid Adil and P. Umesh Chandran Goud},
url = {https://cmegeriatricmed.co.uk/article/assessment-of-intravesical-prostatic-protrusion-and-its-association-with-severity-of-lower-urinary-tract-symptoms-in-benign-prostatic-hyperplasia-a-prospective-observational-study--1514/},
doi = {10.61336/cmejgm/2026-04-42},
issn = {1475-1453},
year = {2026},
date = {2026-04-25},
urldate = {2026-04-25},
journal = {CME Journal of Geriatric Medicine},
volume = {18},
issue = {4},
pages = {271-274},
abstract = {Introduction: Benign prostatic hyperplasia (BPH) is a prevalent condition in the aging male population and represents a significant cause of lower urinary tract symptoms. Intravesical prostatic protrusion (IPP) is gaining importance as a non-invasive marker for predicting bladder outlet obstruction and clinical severity.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Benign prostatic hyperplasia (BPH) is a prevalent condition in the aging male population and represents a significant cause of lower urinary tract symptoms. Intravesical prostatic protrusion (IPP) is gaining importance as a non-invasive marker for predicting bladder outlet obstruction and clinical severity.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.
Reddy, S. Chandra; Golla, Abhishek; Zoheb, Mohammed; Bhat, Rama
Clinical profile of acute pulmonary thromboembolism and prognostic value of troponin-T and sPESI in acute pulmonary thromboembolism Journal Article
In: International Journal of Medicine and Public Health, vol. 16, iss. 2, pp. 1357-1363, 2026, ISSN: 2230-8598.
@article{Reddy_2026,
title = {Clinical profile of acute pulmonary thromboembolism and prognostic value of troponin-T and sPESI in acute pulmonary thromboembolism},
author = {S. Chandra Reddy and Abhishek Golla and Mohammed Zoheb and Rama Bhat},
url = {https://www.ijmedph.org/Uploads/Volume16Issue2/227_4934_IJMEDPH_S_Chandra_Reddy_1357_1363.pdf},
doi = {10.70034/ijmedph.2026.2.227},
issn = {2230-8598},
year = {2026},
date = {2026-04-09},
urldate = {2026-04-09},
journal = {International Journal of Medicine and Public Health},
volume = {16},
issue = {2},
pages = {1357-1363},
abstract = {Background: Venous thromboembolism (VTE) is common with high recurrence rates. Even though it is lethal, it is overlooked. It is associated with long term complications. For India, large-scale studies are lacking In view of
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Venous thromboembolism (VTE) is common with high recurrence rates. Even though it is lethal, it is overlooked. It is associated with long term complications. For India, large-scale studies are lacking In view of
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.
Ali, Shireen Adeeb Mujtaba
Revisiting perceptual distortions in the age of generative artificial intelligence: A modern perspective on “Alice in Wonderland Syndrome” Journal Article
In: SBV Journal of Basic, Clinical and Applied Health Science, vol. 9, iss. 2, pp. 157–158, 2026, ISSN: 2581-6039.
@article{Ali_2026d,
title = {Revisiting perceptual distortions in the age of generative artificial intelligence: A modern perspective on “Alice in Wonderland Syndrome”},
author = {Shireen Adeeb Mujtaba Ali},
url = {https://www.ovid.com/jnls/sbvj/fulltext/10.4103/sbvj.sbvj_72_25~revisiting-perceptual-distortions-in-the-age-of-generative},
doi = {10.4103/sbvj.sbvj_72_25},
issn = {2581-6039},
year = {2026},
date = {2026-04-01},
urldate = {2026-04-01},
journal = {SBV Journal of Basic, Clinical and Applied Health Science},
volume = {9},
issue = {2},
pages = {157–158},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Books Published
2025
Manorenj, Sandhya
Seizure Semiology in Clinical Practice: From symptom analysis to localization Book
Kindle, Amazon KDP, 2025, ISBN: 9798241833440.
@book{Manorenj_2025j,
title = {Seizure Semiology in Clinical Practice: From symptom analysis to localization},
author = {Sandhya Manorenj},
url = {https://www.amazon.in/Seizure-Semiology-Clinical-Practice-Localization-ebook/dp/B0GDHS7TFY},
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year = {2025},
date = {2025-12-31},
number = { ASIN: B0GDHS7TFY },
publisher = {Amazon KDP},
edition = {Kindle},
abstract = {Seizure Semiology in Clinical Practice is designed as a practical and clinically oriented guide to understanding seizure manifestations and their localizing and lateralizing value. The book serves as a valuable resource for neurology residents, general medicine residents, epilepsy fellows, budding neurologists, epileptologists, and neurotechnologists by translating bedside observations into meaningful diagnostic insights. Emphasis is placed on real-world application, helping readers correlate seizure behaviors with underlying neuroanatomy and an approach to history taking. By strengthening clinical acumen and improving seizure recognition, this book ultimately supports accurate diagnosis, timely referral, and optimal management, thereby enhancing the quality of care delivered to patients with epilepsy and related seizure disorders.},
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Seizure Semiology in Clinical Practice is designed as a practical and clinically oriented guide to understanding seizure manifestations and their localizing and lateralizing value. The book serves as a valuable resource for neurology residents, general medicine residents, epilepsy fellows, budding neurologists, epileptologists, and neurotechnologists by translating bedside observations into meaningful diagnostic insights. Emphasis is placed on real-world application, helping readers correlate seizure behaviors with underlying neuroanatomy and an approach to history taking. By strengthening clinical acumen and improving seizure recognition, this book ultimately supports accurate diagnosis, timely referral, and optimal management, thereby enhancing the quality of care delivered to patients with epilepsy and related seizure disorders.
Hasan, Ashfaq
The Principles of Pulmonary Diagnosis: Critical Concepts and a Structured Approach Book
1, Springer Nature Singapore, 2025, ISBN: 9789819678105.
@book{Hasan_2025,
title = {The Principles of Pulmonary Diagnosis: Critical Concepts and a Structured Approach},
author = { Ashfaq Hasan},
url = {https://link.springer.com/book/10.1007/978-981-96-7810-5},
doi = {10.1007/978-981-96-7810-5},
isbn = {9789819678105},
year = {2025},
date = {2025-11-23},
urldate = {2025-11-23},
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edition = {1},
abstract = {By closely integrating pathophysiological concepts into the diagnostic process, this book adopts a strong analytical approach to the diagnosis of pulmonary diseases. A syndrome-based calibrated strategy takes into account confusing similarities and emphasizes key differences between diseases, and helps build valuable concepts that serve the clinician in unravelling diagnostic dilemmas in real-world settings.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.},
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By closely integrating pathophysiological concepts into the diagnostic process, this book adopts a strong analytical approach to the diagnosis of pulmonary diseases. A syndrome-based calibrated strategy takes into account confusing similarities and emphasizes key differences between diseases, and helps build valuable concepts that serve the clinician in unravelling diagnostic dilemmas in real-world settings.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.
2024
Hussain, Mohammed Raheem
Respiratory Medicine Made Simplified Book
1st, AkiNik Publications, 169, C-11, Sector-3, Rohini-110085, New Delhi, India., 2024, ISBN: 9789361351266.
@book{2024,
title = {Respiratory Medicine Made Simplified},
author = {Mohammed Raheem Hussain},
url = {https://www.akinik.com/products/3112/respiratory-medicine-made-simplified},
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edition = {1st},
abstract = {Respiratory medicine plays a vital role in healthcare, addressing diseases that impact breathing and lung function. This simplified guide breaks down complex respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and respiratory infections. It covers essential aspects, including pathophysiology, diagnostic approaches, treatment strategies, and preventive measures. By simplifying medical concepts, this resource aims to enhance understanding for medical students, healthcare practitioners, and general readers interested in respiratory health and disease management.},
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Respiratory medicine plays a vital role in healthcare, addressing diseases that impact breathing and lung function. This simplified guide breaks down complex respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and respiratory infections. It covers essential aspects, including pathophysiology, diagnostic approaches, treatment strategies, and preventive measures. By simplifying medical concepts, this resource aims to enhance understanding for medical students, healthcare practitioners, and general readers interested in respiratory health and disease management.
2023
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology Theory/Practical skills,Viva Book
3rd, Paras Medical Books Pvt. Ltd., Hyderabad, 2023, ISBN: 978-81-95819-17-1.
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title = {Forensic Medicine and Toxicology Theory/Practical skills,Viva},
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year = {2023},
date = {2023-01-01},
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2021
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology Theory/Practical Skills, Viva Book
2nd, Paras Medical Books Pvt. Ltd., Hyderabad, 2021, ISBN: 978-8195271580.
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2020
Khaleel, Mohammed
Handbook on Novel Coronavirus: What You Need to Know? Book
1st, IP Innovative Publication Pvt. Ltd., New Delhi, 2020, ISBN: 9789388022491.
@book{Khaleel_2020,
title = {Handbook on Novel Coronavirus: What You Need to Know?},
author = {Mohammed Khaleel},
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isbn = {9789388022491},
year = {2020},
date = {2020-06-30},
booktitle = {Handbook on Novel Coronavirus: What You Need to Know?},
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edition = {1st},
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2018
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology (Theory/Practical and Viva) Book
1st, Paras Medical Books Pvt. Ltd., Hyderabad, 2018, ISBN: 978-93-86480-17-0.
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2016
Hasan, Ashfaq
The Slow Stain Book
2nd, Ashfaq Hasan, Hyderabad, 2016, ISBN: 9879352671144.
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title = {The Slow Stain},
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date = {2016-01-01},
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publisher = {Ashfaq Hasan},
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2013
Mathur, Shobhana
Principles of Pharmacology for B.Sc. Nursing Book
2nd, Frontline Publications, 2013, ISBN: 9788189966140.
@book{Mathur_2013,
title = {Principles of Pharmacology for B.Sc. Nursing},
author = {Shobhana Mathur},
isbn = { 9788189966140},
year = {2013},
date = {2013-01-01},
booktitle = {Principles of Pharmacology for B.Sc. Nursing},
publisher = {Frontline Publications},
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Hasan, Ashfaq
Handbook of Blood Gas/Acid-Base Interpretation Book
Springer London, 2013, ISBN: 9781447143154.
@book{Hasan_2013,
title = {Handbook of Blood Gas/Acid-Base Interpretation},
author = {Ashfaq Hasan},
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doi = {10.1007/978-1-4471-4315-4},
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Hasan, Ashfaq
Zrozumiec wentylacje mechaniczna Book
Medipage, Warszawa, 2013, ISBN: 9788361104773.
@book{Hasan_2013b,
title = {Zrozumiec wentylacje mechaniczna},
author = {Ashfaq Hasan},
editor = {Dariusz Meciejewski [Translation from English to Polish]},
isbn = {9788361104773},
year = {2013},
date = {2013-01-01},
booktitle = {Zrozumiec wentylacje mechaniczna},
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Mrudula, Chandrupatla
Handbook of Muscles Book
3rd, Osmania Medical Publishers, Hyderabad, 2013.
@book{Mrudula_2013,
title = {Handbook of Muscles},
author = {Chandrupatla Mrudula},
year = {2013},
date = {2013-01-01},
booktitle = {Handbook of Muscles},
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2012
Mrudula, Chandrupatla; Krishnaiah, M.
Concise Anatomy Book
1st (Reprint), Osmania Medical Publishers, Hyderabad, 2012.
@book{Mrudula_2012,
title = {Concise Anatomy},
author = {Chandrupatla Mrudula and M. Krishnaiah},
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date = {2012-01-01},
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2010
Hasan, Ashfaq
Understanding mechanical ventilation Book
2, Springer-Verlag, London, England, 2010, ISBN: 978-1-84882-868-1.
@book{Hasan_2010,
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Chapters Published in Books
2026
Hazari, Mohammed Abdul Hannan; Arifuddin, Mehnaaz Sameera
Precision medicine: Application of artificial intelligence (AI) for ultra-personalization of health needs Book Chapter
In: Maurya, Archana; Singh, Avinash Kumar; Sharma, Kanika Sood; Khushbu,; Nayak, Jarapla Srinivas; Sajjanavar, Ashwini; Ghosh, Jagannath; Chivukula, Siva Subrahmanyam; Quasar, Rehana (Ed.): Evidence-Based Practice in Healthcare: Integrating Medicine, Pharmacy, and Nursing, vol. 6, Chapter 8, pp. 62–87, Iterative International Publishers (IIP), IIP Series, 2026, ISBN: 9788167740434.
@inbook{Hazari_2026,
title = {Precision medicine: Application of artificial intelligence (AI) for ultra-personalization of health needs},
author = {Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin},
editor = {Archana Maurya and Avinash Kumar Singh and Kanika Sood Sharma and Khushbu and Jarapla Srinivas Nayak and Ashwini Sajjanavar and Jagannath Ghosh and Siva Subrahmanyam Chivukula and Rehana Quasar},
url = {https://iipseries.org/viewpaper.php?pid=10669&pt=precision-medicine-application-of-artificial-intelligence-ai-for-ultra-personalization-of-health-needs},
doi = {10.58532/nbennurebphv6b2p1c8},
isbn = {9788167740434},
year = {2026},
date = {2026-06-01},
urldate = {2026-06-01},
booktitle = {Evidence-Based Practice in Healthcare: Integrating Medicine, Pharmacy, and Nursing},
volume = {6},
pages = {62–87},
publisher = {Iterative International Publishers (IIP)},
edition = {IIP Series},
chapter = {8},
series = {S1063B2},
abstract = {Healthcare ecosystem can be conveniently sub-divided into i) central medical domain, led by human or healthcare worker capabilities and ii) peripheral domain, encompassing the biomedical devices, computers, information technology applications, etc. The interplay between the central and peripheral domains complement in better assessment of healthcare needs and deliver the appropriate care. The applications of computers and information technology (IT) have eased how a health event is evaluated and assist medical personnel in addressing the health need. Precision Medicine approach is targeted at benefitting the patients and improving the health outcomes but involves diverse aspects of healthcare - clinical evaluation, diagnostic approaches and therapeutic interventions to disease management based on genetic variations in patients. Such detailed activities need thorough collaboration of all aspects of medical practice leveraged by information technology in real-time. The advent of artificial intelligence (AI) has totally changed the landscape of workspaces in almost all industries; so as the healthcare industry, which is also greatly impacted by application of artificial intelligence (AI). AI is now being bundled with more and more healthcare equipment and healthcare services. AI will define new scopes in practice of Precision Medicine by enabling the e-collaboration of sub-segments of precision medicine with little human interference.},
keywords = {},
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Healthcare ecosystem can be conveniently sub-divided into i) central medical domain, led by human or healthcare worker capabilities and ii) peripheral domain, encompassing the biomedical devices, computers, information technology applications, etc. The interplay between the central and peripheral domains complement in better assessment of healthcare needs and deliver the appropriate care. The applications of computers and information technology (IT) have eased how a health event is evaluated and assist medical personnel in addressing the health need. Precision Medicine approach is targeted at benefitting the patients and improving the health outcomes but involves diverse aspects of healthcare - clinical evaluation, diagnostic approaches and therapeutic interventions to disease management based on genetic variations in patients. Such detailed activities need thorough collaboration of all aspects of medical practice leveraged by information technology in real-time. The advent of artificial intelligence (AI) has totally changed the landscape of workspaces in almost all industries; so as the healthcare industry, which is also greatly impacted by application of artificial intelligence (AI). AI is now being bundled with more and more healthcare equipment and healthcare services. AI will define new scopes in practice of Precision Medicine by enabling the e-collaboration of sub-segments of precision medicine with little human interference.
Ali, Shireen Adeeb Mujtaba; Amrin, Shaheen Siddiqua; Naveed, M. Aleemuddin; Mujahid, Mohammed Naseeruddin
Artificial intelligence-powered pipelines for therapeutic innovation Book Chapter
In: Boubaker, Olfa (Ed.): AI and Data Science in Medical Research, Chapter 9, pp. 243–262, Elsevier, 2026, ISBN: 9780443276385.
@inbook{Ali_2026c,
title = {Artificial intelligence-powered pipelines for therapeutic innovation},
author = {Shireen Adeeb Mujtaba Ali and Shaheen Siddiqua Amrin and M. Aleemuddin Naveed and Mohammed Naseeruddin Mujahid},
editor = {Olfa Boubaker},
url = {https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443276385000110?via%3Dihub},
doi = {10.1016/b978-0-443-27638-5.00011-0},
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year = {2026},
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pages = {243–262},
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chapter = {9},
abstract = {The adoption of data science and artificial intelligence (AI) in pharmaceutical research signifies an unprecedented improvement in the speed at which new medicinal compounds are discovered and the efficiency of medication development processes. Due to the high failure rate, duration, and expense of traditional drug discovery procedures, creative solutions to improve efficacy and efficiency are required. By utilizing large datasets and sophisticated algorithms to identify novel therapeutic targets, anticipate drug interactions, and expedite clinical trial procedures, AI and data science provide effective methods to tackle these problems. AI-driven algorithms, such as machine learning and deep learning, make it possible to analyze complicated biological data and find possible drug candidates and biomarkers with previously unheard-of speed and precision. These models have the ability to combine diverse data sources, including clinical, proteomic, and genetic data, to produce useful insights and forecast treatment effectiveness. In addition, data science approaches help to optimize drug development pipelines through enhanced target validation, optimized lead compounds, and customized treatment plans according to individual patient profiles. By utilizing these technologies, scientists may improve the accuracy of preclinical and clinical studies, expedite the release of new and effective treatments into the market, and drastically cut the time and expense associated with drug discovery. This chapter examines the revolutionary influence of AI and data science on drug discovery and development, which also highlights important approaches, case examples, and potential future prospects for utilizing these technologies in the search for novel medicines.},
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The adoption of data science and artificial intelligence (AI) in pharmaceutical research signifies an unprecedented improvement in the speed at which new medicinal compounds are discovered and the efficiency of medication development processes. Due to the high failure rate, duration, and expense of traditional drug discovery procedures, creative solutions to improve efficacy and efficiency are required. By utilizing large datasets and sophisticated algorithms to identify novel therapeutic targets, anticipate drug interactions, and expedite clinical trial procedures, AI and data science provide effective methods to tackle these problems. AI-driven algorithms, such as machine learning and deep learning, make it possible to analyze complicated biological data and find possible drug candidates and biomarkers with previously unheard-of speed and precision. These models have the ability to combine diverse data sources, including clinical, proteomic, and genetic data, to produce useful insights and forecast treatment effectiveness. In addition, data science approaches help to optimize drug development pipelines through enhanced target validation, optimized lead compounds, and customized treatment plans according to individual patient profiles. By utilizing these technologies, scientists may improve the accuracy of preclinical and clinical studies, expedite the release of new and effective treatments into the market, and drastically cut the time and expense associated with drug discovery. This chapter examines the revolutionary influence of AI and data science on drug discovery and development, which also highlights important approaches, case examples, and potential future prospects for utilizing these technologies in the search for novel medicines.
Ali, Shireen Adeeb Mujtaba; Mujiburrehman, Shaikh Shagufta; Vazirizadeh, Amir; Barwant, Mukul Machhindra
Microbial innovations in the fight against hunger Book Chapter
In: Babaniyi, Babafemi Raphael; Sawicka, Barbara; Barwant, Mukul Machhindra; Aransiola, Sesan Abiodun (Ed.): Leveraging Microbial Technology for Food Security, Chapter 6, pp. 84–104, CRC Press, 1st, 2026, ISBN: 9781003650881.
@inbook{Ali_2026b,
title = {Microbial innovations in the fight against hunger},
author = {Shireen Adeeb Mujtaba Ali and Shaikh Shagufta Mujiburrehman and Amir Vazirizadeh and Mukul Machhindra Barwant},
editor = {Babafemi Raphael Babaniyi and Barbara Sawicka and Mukul Machhindra Barwant and Sesan Abiodun Aransiola},
url = {https://www.taylorfrancis.com/chapters/edit/10.1201/9781003650881-6/microbial-innovations-fight-hunger-shireen-adeeb-mujtaba-ali-shaikh-shagufta-mujiburrehman-amir-vazirizadeh-mukul-machhindra-barwant},
doi = {10.1201/9781003650881-6},
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year = {2026},
date = {2026-04-22},
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booktitle = {Leveraging Microbial Technology for Food Security},
pages = {84–104},
publisher = {CRC Press},
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chapter = {6},
abstract = {As the global population continues to rise and resources become increasingly limited, hunger remains a critical challenge, projected to worsen by 2050. Ensuring a sustainable and sufficient food supply requires innovative solutions, with microbiology playing a key role in enhancing food production, quality, safety, and nutrition, contributing to the United Nations Zero Hunger goal. Microorganisms are essential to agriculture, food processing, and health, offering ecofriendly alternatives to chemical-intensive methods. Beneficial microbes such as nitrogen-fixing bacteria, mycorrhizal fungi, and phosphate-solubilizing bacteria improve soil fertility, increasing crop yield and sustainability. Biopesticides and biofertilizers reduce reliance on synthetic chemicals, promoting healthier ecosystems. This chapter explores the diversity and applications of microorganisms in agriculture, food, and health, emphasizing their immense potential in solving global food challenges. By harnessing microbial breakthroughs, we can develop sustainable solutions to combat hunger and create a resilient global food system.},
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As the global population continues to rise and resources become increasingly limited, hunger remains a critical challenge, projected to worsen by 2050. Ensuring a sustainable and sufficient food supply requires innovative solutions, with microbiology playing a key role in enhancing food production, quality, safety, and nutrition, contributing to the United Nations Zero Hunger goal. Microorganisms are essential to agriculture, food processing, and health, offering ecofriendly alternatives to chemical-intensive methods. Beneficial microbes such as nitrogen-fixing bacteria, mycorrhizal fungi, and phosphate-solubilizing bacteria improve soil fertility, increasing crop yield and sustainability. Biopesticides and biofertilizers reduce reliance on synthetic chemicals, promoting healthier ecosystems. This chapter explores the diversity and applications of microorganisms in agriculture, food, and health, emphasizing their immense potential in solving global food challenges. By harnessing microbial breakthroughs, we can develop sustainable solutions to combat hunger and create a resilient global food system.
2025
Ali, Shireen Adeeb Mujtaba; Begum, Safia; Naveed, M. Aleemuddin; Mujahid, Mohammed Naseeruddin
Precision Healthcare: Advancing Patient Care Through Decision Tools, Wearables, and Ethical Considerations Book Chapter
In: Gupta, Neeraj; Ibrahim, Abdelhameed; Vyas, Bhavesh; Jeet, Shobhna (Ed.): Precision Healthcare: Patient Care, Decision Tools, Wearables, Legal and Ethical Issues, pp. 195–205, BENTHAM SCIENCE PUBLISHERS, 2025, ISBN: 9798898813512.
@inbook{Ali_2025c,
title = {Precision Healthcare: Advancing Patient Care Through Decision Tools, Wearables, and Ethical Considerations},
author = {Shireen Adeeb Mujtaba Ali and Safia Begum and M. Aleemuddin Naveed and Mohammed Naseeruddin Mujahid},
editor = {Neeraj Gupta and Abdelhameed Ibrahim and Bhavesh Vyas and Shobhna Jeet},
url = {https://www.eurekaselect.com/chapter/26828},
doi = {10.2174/9798898813512125010015},
isbn = {9798898813512},
year = {2025},
date = {2025-12-19},
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2023
Reddy, Uppin Narayan
Allergen Immunotherapy Book Chapter
In: Kumar, R. Remesh; Mohan, R. Krishna; Gupta, Neeraj; Ashok, Narmada (Ed.): IAP Case Based Reviews in Pediatric Allergy, Chapter 41, pp. 328-334, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, 1st, 2023, ISBN: 9789354659898.
@inbook{Reddy_2023,
title = {Allergen Immunotherapy},
author = {Uppin Narayan Reddy},
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year = {2023},
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booktitle = {IAP Case Based Reviews in Pediatric Allergy},
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2022
Haneef, Nayeem Sadath
Alopecia areata Book Chapter
In: Sacchidanand, S.; Savitha, A. S.; Shilpa, K.; Kumar, B. M. Shashi (Ed.): IADVL textbook of dermatology, Bhalani Publishing House, Mumbai, 5th, 2022, ISBN: 9789381496701.
@inbook{Haneef_2022,
title = {Alopecia areata},
author = {Nayeem Sadath Haneef},
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isbn = {9789381496701},
year = {2022},
date = {2022-01-01},
booktitle = {IADVL textbook of dermatology},
publisher = {Bhalani Publishing House},
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2021
Nasirabadi, Minhajzafar; Reddy, V. George; Akula, Vishal
COVID 19 Pandemic and Telemedicine Practice in India Book Chapter
In: Brahma, Arabinda; Reddy, George V.; Sarkhel, Sujit (Ed.): Parallel Pandemic of 2020, Chapter 5, pp. 56-70, Indian Psychiatric Society, Gurugram, 1st, 2021, ISBN: 9798772377505.
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title = {COVID 19 Pandemic and Telemedicine Practice in India},
author = {Minhajzafar Nasirabadi and V. George Reddy and Vishal Akula},
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url = {https://deemagclinic.com/2021/12/07/parallel-pandemic-of-2020/},
isbn = {9798772377505},
year = {2021},
date = {2021-07-12},
booktitle = {Parallel Pandemic of 2020},
pages = {56-70},
publisher = {Indian Psychiatric Society},
address = {Gurugram},
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chapter = {5},
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tppubtype = {inbook}
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Mukheem, Abdul; Shahabuddin, Syed; Khan, Aleem Ahmed; Hossain, Md. Murad; Jasni, Ainil Hawa; Sridewi, Nanthini
Bio-plastic polyhydroxyalkanoate (PHA): Applications in modern medicine Book Chapter
In: Kuddus, Mohammed; Roohi, (Ed.): Bioplastics for Sustainable Development, Chapter 8, pp. 231-257, Springer Singapore, 2021, ISBN: 9789811618239.
@inbook{Mukheem_2021,
title = {Bio-plastic polyhydroxyalkanoate (PHA): Applications in modern medicine},
author = {Abdul Mukheem and Syed Shahabuddin and Aleem Ahmed Khan and Md. Murad Hossain and Ainil Hawa Jasni and Nanthini Sridewi},
editor = {Mohammed Kuddus and Roohi},
url = {https://link.springer.com/chapter/10.1007/978-981-16-1823-9_8},
doi = {10.1007/978-981-16-1823-9_8},
isbn = {9789811618239},
year = {2021},
date = {2021-06-22},
urldate = {2021-01-01},
booktitle = {Bioplastics for Sustainable Development},
pages = {231-257},
publisher = {Springer Singapore},
chapter = {8},
keywords = {},
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}
Manorenj, Sandhya; Shaik, Reshma Sultana
Clinical aspects of Moyamoya disease. In: Moyamoya disease- a disease to count on in your daily practice Book Chapter
In: Chapter 3, IntechOpen, 2021, ISBN: 978-1-83968-387-9.
@inbook{Manorenj_2021d,
title = {Clinical aspects of Moyamoya disease. In: Moyamoya disease- a disease to count on in your daily practice},
author = {Sandhya Manorenj and Reshma Sultana Shaik},
url = {https://www.intechopen.com/chapters/75446},
doi = {10.5772/intechopen.92950},
isbn = {978-1-83968-387-9},
year = {2021},
date = {2021-02-26},
urldate = {2021-02-26},
publisher = {IntechOpen},
chapter = {3},
abstract = {Moyamoya disease is a chronic progressive, non-atherosclerotic, occlusive intracranial vasculopathy involving major cerebral arteries around the circle of Willis. MMD occurs frequently in East Asian populations but the disease can affect the American and European ethnicities as well. Knowledge of clinical aspects of Moyamoya disease (MMD) is important in view of distinctive clinical presentation observed in children and adults. MMD has bimodal age of distribution, with peaks in the first and last decades of life. Childhood MMD is characterised by Ischemic manifestation (Transient ischemic attack, Cerebral Infarction), whereas adult MMD presents with hemorrhagic manifestations (Intracerebral haemorrhage, Intraventricular bleed). Refractory headache, seizure and ophthalmological abnormalities are other clinical presentations of MMD. A high index of clinical suspicion and an eye to recognise the common as well as unusual manifestations of the disease and inciting events may prevent delay in the diagnosis. A thorough knowledge about the varied clinical presentation would aid clinician for early diagnosis and management of this rare entity. The present article provides extensive review on the clinical aspects of MMD amongst adults and paediatric population, on the basis of previous articles and research studies.},
keywords = {},
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Moyamoya disease is a chronic progressive, non-atherosclerotic, occlusive intracranial vasculopathy involving major cerebral arteries around the circle of Willis. MMD occurs frequently in East Asian populations but the disease can affect the American and European ethnicities as well. Knowledge of clinical aspects of Moyamoya disease (MMD) is important in view of distinctive clinical presentation observed in children and adults. MMD has bimodal age of distribution, with peaks in the first and last decades of life. Childhood MMD is characterised by Ischemic manifestation (Transient ischemic attack, Cerebral Infarction), whereas adult MMD presents with hemorrhagic manifestations (Intracerebral haemorrhage, Intraventricular bleed). Refractory headache, seizure and ophthalmological abnormalities are other clinical presentations of MMD. A high index of clinical suspicion and an eye to recognise the common as well as unusual manifestations of the disease and inciting events may prevent delay in the diagnosis. A thorough knowledge about the varied clinical presentation would aid clinician for early diagnosis and management of this rare entity. The present article provides extensive review on the clinical aspects of MMD amongst adults and paediatric population, on the basis of previous articles and research studies.
2019
Hasan, Ashfaq
History of TB: Robert Koch and Beyond Book Chapter
In: Hasnain, Seyed Ehtesham; Ehtesham, Nasreen Z.; Grover, Sonam (Ed.): Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions, Chapter 1, pp. 3-16, Springer Singapore, 2019, ISBN: 9789813294134.
@inbook{Hasan_2019,
title = {History of TB: Robert Koch and Beyond},
author = {Ashfaq Hasan},
editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover},
url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_1},
doi = {10.1007/978-981-32-9413-4_1},
isbn = {9789813294134},
year = {2019},
date = {2019-12-01},
urldate = {2019-01-01},
booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions},
pages = {3-16},
publisher = {Springer Singapore},
chapter = {1},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Hasan, Ashfaq; Praveen, Sai Haranath; Tarke, Chandrakant; Breik, Fahad Abdullah Bin
Clinical Aspects and Principles of Management of Tuberculosis Book Chapter
In: Hasnain, Seyed Ehtesham; Ehtesham, Nasreen Z.; Grover, Sonam (Ed.): Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions, Chapter 20, pp. 355-374, Springer Singapore, 2019, ISBN: 9789813294134.
@inbook{Hasan_2019b,
title = {Clinical Aspects and Principles of Management of Tuberculosis},
author = {Ashfaq Hasan and Sai Haranath Praveen and Chandrakant Tarke and Fahad Abdullah Bin Breik},
editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover},
url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_20},
doi = {10.1007/978-981-32-9413-4_20},
isbn = {9789813294134},
year = {2019},
date = {2019-12-01},
urldate = {2019-01-01},
booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions},
pages = {355-374},
publisher = {Springer Singapore},
chapter = {20},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Srinivas, Putta; Haneef, Nayeem Sadath
Code of medical ethics Book Chapter
In: Mysore, Venkataram; Bhat, Satish; Sirur, Subodh Premanand (Ed.): Medico-legal aspects of dermatology and plastic surgery, Chapter 3, pp. 22-37, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, 1st, 2019, ISBN: 9789352708970.
@inbook{Haneef_2019,
title = {Code of medical ethics},
author = {Putta Srinivas and Nayeem Sadath Haneef },
editor = {Venkataram Mysore and Satish Bhat and Subodh Premanand Sirur},
doi = {10.5005/jp/books/18187_4},
isbn = {9789352708970},
year = {2019},
date = {2019-01-01},
booktitle = {Medico-legal aspects of dermatology and plastic surgery},
pages = {22-37},
publisher = {Jaypee Brothers Medical Publishers (P) Ltd},
address = {New Delhi},
edition = {1st},
chapter = {3},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2017
Khan, Aleem Ahmed; Vishwakarma, Sandeep Kumar; Bardia, Avinash; Habeeb, Md. Aejaz; Dhayal, M.
Repopulation of cirrhotic liver by hepatic stem/progenitor cells Book Chapter
In: Muriel, Pablo (Ed.): Liver Pathophysiology: Therapies and Antioxidants, Chapter 59, pp. 817-836, Academic Press, Boston, 2017, ISBN: 9780128042748.
@inbook{Khan_2017d,
title = {Repopulation of cirrhotic liver by hepatic stem/progenitor cells},
author = {Aleem Ahmed Khan and Sandeep Kumar Vishwakarma and Avinash Bardia and Md. Aejaz Habeeb and M. Dhayal},
editor = {Pablo Muriel},
url = {https://www.sciencedirect.com/science/article/abs/pii/B978012804274800059X?via%3Dihub},
doi = {10.1016/b978-0-12-804274-8.00059-x},
isbn = {9780128042748},
year = {2017},
date = {2017-01-01},
urldate = {2017-01-01},
booktitle = {Liver Pathophysiology: Therapies and Antioxidants},
pages = {817-836},
publisher = {Academic Press},
address = {Boston},
chapter = {59},
abstract = {Liver cirrhosis is one of the major causes of morbidity and mortality worldwide. Liver transplantation is the only successful and curative option for the management of this disease. However, cost effectiveness, timely availability, operative risks, need of life-long immunosuppressant, and shortage of donor organs are major challenges to fulfill the demand. Stem cells transplantation has emerged as a bridge to liver transplantation for the repopulation of cirrhotic liver due to its potential for long-term proliferation. Human fetal liver–derived stem/progenitor cells (fLSPCs) are emerging as safe and effective therapeutic possibility in the management of liver cirrhosis due to their low immunogenicity and high proliferative ability. Combination of mesenchymal stem cells with fLSPCs could be the best option to ameliorate immunomodulation, fibrotic reconstruction, and repopulation of lost hepatocytes to replenish the deficient liver functions. Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.},
keywords = {},
pubstate = {published},
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}
Liver cirrhosis is one of the major causes of morbidity and mortality worldwide. Liver transplantation is the only successful and curative option for the management of this disease. However, cost effectiveness, timely availability, operative risks, need of life-long immunosuppressant, and shortage of donor organs are major challenges to fulfill the demand. Stem cells transplantation has emerged as a bridge to liver transplantation for the repopulation of cirrhotic liver due to its potential for long-term proliferation. Human fetal liver–derived stem/progenitor cells (fLSPCs) are emerging as safe and effective therapeutic possibility in the management of liver cirrhosis due to their low immunogenicity and high proliferative ability. Combination of mesenchymal stem cells with fLSPCs could be the best option to ameliorate immunomodulation, fibrotic reconstruction, and repopulation of lost hepatocytes to replenish the deficient liver functions. Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.
2014
Hasan, Ashfaq; Uzma, Nazia; Kumar, Bhaskarpillai Santhosh
Obstructive sleep apnea and the metabolic syndrome: Clinical profiles and relationships Book Chapter
In: Watson, Ronald Ross (Ed.): Modulation of sleep by obesity, diabetes, age, and diet, Chapter 16, pp. 139-147, Academic Press, 1st, 2014, ISBN: 9780128103074.
@inbook{nokey,
title = {Obstructive sleep apnea and the metabolic syndrome: Clinical profiles and relationships},
author = {Ashfaq Hasan and Nazia Uzma and Bhaskarpillai Santhosh Kumar},
editor = {Ronald Ross Watson},
url = {https://www.elsevier.com/books/modulation-of-sleep-by-obesity-diabetes-age-and-diet/watson/978-0-12-420168-2},
isbn = {9780128103074},
year = {2014},
date = {2014-09-14},
urldate = {2014-09-14},
booktitle = {Modulation of sleep by obesity, diabetes, age, and diet},
pages = {139-147},
publisher = {Academic Press},
edition = {1st},
chapter = {16},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2013
Paspala, Syed Ameer Basha; Khan, Aleem Ahmed; Vishwakarma, Sandeep; Murthy, T. V. Ramakrishna
Pluripotent stem cells for neural regeneration Book Chapter
In: Danquah, Michael K.; Mahato, Ram I. (Ed.): Emerging Trends in Cell and Gene Therapy, Chapter 16, pp. 347-371, Humana Press, 2013, ISBN: 9781627034173.
@inbook{Paspala_2013,
title = {Pluripotent stem cells for neural regeneration},
author = {Syed Ameer Basha Paspala and Aleem Ahmed Khan and Sandeep Vishwakarma and T. V. Ramakrishna Murthy},
editor = {Michael K. Danquah and Ram I. Mahato},
url = {https://link.springer.com/chapter/10.1007/978-1-62703-417-3_16},
doi = {10.1007/978-1-62703-417-3_16},
isbn = {9781627034173},
year = {2013},
date = {2013-04-17},
urldate = {2013-01-01},
booktitle = {Emerging Trends in Cell and Gene Therapy},
pages = {347-371},
publisher = {Humana Press},
chapter = {16},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2012
Tripura, Chaturvedula; Khan, Aleem Ahmed; Pande, Gopal
Cell based therapy for chronic liver disease: Role of fetal liver cells in restoration of the liver cell functions Book Chapter
In: Baptista, Pedro M. (Ed.): Liver Regeneration, Chapter 12, InTechOpen, 2012, ISBN: 9789535106227.
@inbook{Tripura_2012,
title = {Cell based therapy for chronic liver disease: Role of fetal liver cells in restoration of the liver cell functions},
author = {Chaturvedula Tripura and Aleem Ahmed Khan and Gopal Pande},
editor = {Pedro M. Baptista},
url = {https://www.intechopen.com/chapters/36999},
doi = {10.5772/45876},
isbn = {9789535106227},
year = {2012},
date = {2012-05-16},
urldate = {2012-05-01},
booktitle = {Liver Regeneration},
publisher = {InTechOpen},
chapter = {12},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2010
Naimath, Parveen; Khan, Aleem Ahmed; Habeeb, Md. Aejaz; Habibullah, Chitoor Mohammed
Gastrointestinal stem cells Book Chapter
In: Appasani, Krishnarao; Appasani, Raghu K. (Ed.): Stem Cell Biology and Regenerative Medicine, Chapter 13, pp. 219-225, Humana Press, 2010, ISBN: 9781607618591.
@inbook{Parveen_2010,
title = {Gastrointestinal stem cells},
author = {Parveen Naimath and Aleem Ahmed Khan and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah},
editor = {Krishnarao Appasani and Raghu K. Appasani},
url = {https://link.springer.com/chapter/10.1007/978-1-60761-860-7_13},
doi = {10.1007/978-1-60761-860-7_13},
isbn = {9781607618591},
year = {2010},
date = {2010-11-01},
urldate = {2010-10-01},
booktitle = {Stem Cell Biology and Regenerative Medicine},
pages = {219-225},
publisher = {Humana Press},
chapter = {13},
abstract = {Stem cell research is advancing at an incredible pace, with new discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Stem cell research is advancing at an incredible pace, with new discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.