Publications
- Home
- Publications
Journal Articles
2026
Aleem, Mohammed Abdul; Breik, Fahad Abdullah Bin; Hadi, Mohammed Abdul
In: Advances in Clinical Medical Research, vol. 7, iss. 2, pp. 380-388, 2026, ISSN: 2635-0815.
@article{Aleem_2026b,
title = {Role of the cell block technique in pulmonary cytology: enhancing diagnostic accuracy and molecular characterization of lung lesions-a systematic review and meta analysis},
author = {Mohammed Abdul Aleem and Fahad Abdullah Bin Breik and Mohammed Abdul Hadi },
url = {https://acmrjournal.com/index.php/ACMR/article/view/189/153},
issn = {2635-0815},
year = {2026},
date = {2026-06-26},
urldate = {2026-06-26},
journal = {Advances in Clinical Medical Research},
volume = {7},
issue = {2},
pages = {380-388},
abstract = {Background: Pulmonary cytology remains an indispensable diagnostic modality for evaluating lung lesions, particularly in patients undergoing minimally invasive procedures such as fine-needle aspiration cytology (FNAC), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), bronchial brushing, bronchoalveolar lavage (BAL), and pleural fluid cytology. However, conventional cytology smears often present limitations in architectural preservation, ancillary testing, and molecular characterization. The cell block (CB) technique has emerged as a valuable adjunct by providing histology-like sections suitable for immunohistochemistry (IHC) and molecular studies. This systematic review and meta-analysis evaluated the diagnostic and molecular utility of the cell block technique in pulmonary cytology. Materials and Methods: A systematic search of PubMed, Scopus, Web of Science, Embase, and Google Scholar was conducted for studies published between January 2000 and 2025. Eligible studies compared conventional cytology alone with cytology supplemented by cell block preparation in pulmonary specimens. Primary outcomes included diagnostic accuracy, sensitivity, specificity, and adequacy rates. Secondary outcomes included immunocytochemical utility and molecular testing success rates. A random-effects model was employed to calculate pooled effect estimates. Results: A total of 18 studies comprising 4,562 pulmonary specimens met the inclusion criteria. The pooled diagnostic accuracy increased from 78.4% with conventional cytology alone to 91.2% when supplemented with cell block preparation. Meta-analysis demonstrated a significant improvement in diagnostic yield (OR=2.89; 95% CI: 2.11–3.96; p<0.001). Cell block preparations significantly improved specimen adequacy for immunohistochemistry (89.5%) and molecular analysis (84.7%). Subgroup analysis showed superior performance in non-small cell lung carcinoma (NSCLC) characterization and EGFR, ALK, ROS1, and PD-L1 testing. Conclusion: The cell block technique substantially enhances diagnostic precision and molecular characterization in pulmonary cytology. Incorporation of cell block preparation into routine pulmonary cytology workflows is recommended, particularly in the era of precision oncology.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Pulmonary cytology remains an indispensable diagnostic modality for evaluating lung lesions, particularly in patients undergoing minimally invasive procedures such as fine-needle aspiration cytology (FNAC), endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), bronchial brushing, bronchoalveolar lavage (BAL), and pleural fluid cytology. However, conventional cytology smears often present limitations in architectural preservation, ancillary testing, and molecular characterization. The cell block (CB) technique has emerged as a valuable adjunct by providing histology-like sections suitable for immunohistochemistry (IHC) and molecular studies. This systematic review and meta-analysis evaluated the diagnostic and molecular utility of the cell block technique in pulmonary cytology. Materials and Methods: A systematic search of PubMed, Scopus, Web of Science, Embase, and Google Scholar was conducted for studies published between January 2000 and 2025. Eligible studies compared conventional cytology alone with cytology supplemented by cell block preparation in pulmonary specimens. Primary outcomes included diagnostic accuracy, sensitivity, specificity, and adequacy rates. Secondary outcomes included immunocytochemical utility and molecular testing success rates. A random-effects model was employed to calculate pooled effect estimates. Results: A total of 18 studies comprising 4,562 pulmonary specimens met the inclusion criteria. The pooled diagnostic accuracy increased from 78.4% with conventional cytology alone to 91.2% when supplemented with cell block preparation. Meta-analysis demonstrated a significant improvement in diagnostic yield (OR=2.89; 95% CI: 2.11–3.96; p<0.001). Cell block preparations significantly improved specimen adequacy for immunohistochemistry (89.5%) and molecular analysis (84.7%). Subgroup analysis showed superior performance in non-small cell lung carcinoma (NSCLC) characterization and EGFR, ALK, ROS1, and PD-L1 testing. Conclusion: The cell block technique substantially enhances diagnostic precision and molecular characterization in pulmonary cytology. Incorporation of cell block preparation into routine pulmonary cytology workflows is recommended, particularly in the era of precision oncology.
Fareedullah, Mohammed; Ahmed, Mohammed Haseeb; Panga, Shanmuka Nagaraju; ur Rahman, Md Atiqh; Asra,; Fatima, Hasnat; Fatima, Zunera
In: International Journal of Pharmaceutical Sciences Review and Research, vol. 86, iss. 6, no. 01, pp. 1-11, 2026, ISSN: 0976–044X.
@article{nokey,
title = {Antimicrobial utilisation patterns, WHO Aware classification, and resistance profiles in a tertiary care critical care unit: A prospective observational study},
author = {Mohammed Fareedullah and Mohammed Haseeb Ahmed and Shanmuka Nagaraju Panga and Md Atiqh ur Rahman and Asra and Hasnat Fatima and Zunera Fatima},
url = {https://www.globalresearchonline.net/},
doi = {10.47583/ijpsrr.2026.v86i06.001},
issn = {0976–044X},
year = {2026},
date = {2026-06-20},
journal = {International Journal of Pharmaceutical Sciences Review and Research},
volume = {86},
number = {01},
issue = {6},
pages = {1-11},
abstract = {Background: Antimicrobial resistance (AMR) constitutes a critical patient safety threat in intensive care settings, where the convergence of severely ill patients, invasive devices, and extensive broad-spectrum antibiotic use creates conditions that selectively favour resistant pathogens. Systematic evaluation of prescribing patterns, resistance profiles, and alignment with stewardship frameworks is essential to guide rational antimicrobial use.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital
mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Antimicrobial resistance (AMR) constitutes a critical patient safety threat in intensive care settings, where the convergence of severely ill patients, invasive devices, and extensive broad-spectrum antibiotic use creates conditions that selectively favour resistant pathogens. Systematic evaluation of prescribing patterns, resistance profiles, and alignment with stewardship frameworks is essential to guide rational antimicrobial use.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital
mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.
Methods: A prospective observational study was conducted among 100 CCU patients receiving antimicrobial therapy between February and May 2023. Demographic, microbiological, prescribing, AWaRe classification, therapy modification, and outcome data were collected and analysed descriptively.
Results: The mean patient age was 55.5 years; males comprised 54% of the cohort. Urinary tract infections (24%) and sepsis (22%) were the most common primary diagnoses. Diabetes mellitus (49%) and hypertension (47%) were the predominant comorbidities. Gram-negative organisms accounted for 79.1% of isolates, with Escherichia coli predominating. Among 216 antimicrobial prescriptions, Watch-category antibiotics constituted the majority. Piperacillin–tazobactam (14.9%) and ceftriaxone (11.6%) were most frequently prescribed. Meropenem demonstrated the highest sensitivity (71.4%), while ampicillin showed the greatest resistance (18.1%). Guideline concordance was achieved in 90% of cases, although de-escalation occurred in only 11%. The in-hospital
mortality rate was 8%.
Conclusions: Gram-negative pathogens predominated in the CCU. Extensive Watch-category antibiotic use, low de-escalation rates, and increasing resistance to beta-lactams and cephalosporins highlight the need for strengthened antimicrobial stewardship, institutional antibiograms, and culture-guided prescribing.
Aleem, Mohammed Abdul; Breik, Fahad Abdullah Bin; and Mohammed Abdul Muqeeth,
In: International Journal of Medicine, vol. 8, iss. 6, pp. 408-420, 2026, ISSN: 1468-3814.
@article{Aleem_2026,
title = {Artificial intelligence-based prediction of EGFR, ALK, and KRAS oncogenic mutations from histopathological whole-slide images in lung carcinoma: a systematic review and meta-analysis},
author = {Mohammed Abdul Aleem and Fahad Abdullah Bin Breik and and Mohammed Abdul Muqeeth},
url = {https://app.theinternationalmedicine.com/public/testarticle/pdfFile-1781176241094-78577456.pdf},
doi = {10.61336/im/26-06-62},
issn = {1468-3814},
year = {2026},
date = {2026-06-11},
urldate = {2026-06-11},
journal = {International Journal of Medicine},
volume = {8},
issue = {6},
pages = {408-420},
abstract = {Background: The accurate identification of actionable oncogenic driver mutations—epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral proto-oncogene (KRAS)—is indispensable for precision oncology in non-small cell lung carcinoma (NSCLC). Conventional molecular testing remains costly, tissue-consumptive, and inaccessible in resource-limited settings. Artificial intelligence (AI) applied to routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) represents a transformative paradigm for non-invasive genomic inference. This meta-analysis provides the first comprehensive quantitative synthesis of diagnostic accuracy for AI-based mutation prediction from lung histopathology. Methods: A systematic search of PubMed, MEDLINE, Scopus, Web of Science, and EMBASE was conducted from January 2015 to December 2024, following PRISMA 2020 guidelines. Studies employing any AI or machine learning methodology to predict EGFR, ALK, or KRAS mutational status from digitised lung histopathology slides were eligible. Bivariate random-effects modelling was used to pool diagnostic accuracy metrics. Heterogeneity was evaluated using the I² statistic and Cochran's Q test. Quality appraisal was performed using QUADAS-2. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Results: Forty-three studies (n = 28,614 specimens) met inclusion criteria. Pooled area under the receiver operating characteristic curve (AUC) was 0.821 (95% CI: 0.804–0.839) for EGFR, 0.851 (95% CI: 0.829–0.873) for ALK, and 0.741 (95% CI: 0.712–0.770) for KRAS prediction. Sensitivity and specificity were highest for ALK (78.6% and 80.4%, respectively). Substantial heterogeneity was observed (I²: 61–80%). Transformer-based architectures and foundation models yielded superior performance over conventional CNNs (AUC 0.871 vs. 0.808, p < 0.001). Multi-institutional external validation significantly reduced overfitting bias. Conclusion: AI-based histopathological analysis demonstrates clinically meaningful diagnostic accuracy for EGFR and ALK mutation prediction, approaching levels sufficient for triage-level clinical utility. KRAS prediction performance remains suboptimal. Standardisation of cohort assembly, validation protocols, and reporting frameworks is essential before clinical deployment.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: The accurate identification of actionable oncogenic driver mutations—epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral proto-oncogene (KRAS)—is indispensable for precision oncology in non-small cell lung carcinoma (NSCLC). Conventional molecular testing remains costly, tissue-consumptive, and inaccessible in resource-limited settings. Artificial intelligence (AI) applied to routine haematoxylin and eosin (H&E)-stained whole-slide images (WSIs) represents a transformative paradigm for non-invasive genomic inference. This meta-analysis provides the first comprehensive quantitative synthesis of diagnostic accuracy for AI-based mutation prediction from lung histopathology. Methods: A systematic search of PubMed, MEDLINE, Scopus, Web of Science, and EMBASE was conducted from January 2015 to December 2024, following PRISMA 2020 guidelines. Studies employing any AI or machine learning methodology to predict EGFR, ALK, or KRAS mutational status from digitised lung histopathology slides were eligible. Bivariate random-effects modelling was used to pool diagnostic accuracy metrics. Heterogeneity was evaluated using the I² statistic and Cochran's Q test. Quality appraisal was performed using QUADAS-2. Subgroup analyses and meta-regression were conducted to explore sources of heterogeneity. Results: Forty-three studies (n = 28,614 specimens) met inclusion criteria. Pooled area under the receiver operating characteristic curve (AUC) was 0.821 (95% CI: 0.804–0.839) for EGFR, 0.851 (95% CI: 0.829–0.873) for ALK, and 0.741 (95% CI: 0.712–0.770) for KRAS prediction. Sensitivity and specificity were highest for ALK (78.6% and 80.4%, respectively). Substantial heterogeneity was observed (I²: 61–80%). Transformer-based architectures and foundation models yielded superior performance over conventional CNNs (AUC 0.871 vs. 0.808, p < 0.001). Multi-institutional external validation significantly reduced overfitting bias. Conclusion: AI-based histopathological analysis demonstrates clinically meaningful diagnostic accuracy for EGFR and ALK mutation prediction, approaching levels sufficient for triage-level clinical utility. KRAS prediction performance remains suboptimal. Standardisation of cohort assembly, validation protocols, and reporting frameworks is essential before clinical deployment.
Siddiqua, Arshiya; Anupama, Swarna; Reddy, Ramakanth; Jagadeesh, Chittuluri
Role of serum D-dimer in early prediction of organ failure in acute pancreatitis: a retrospective study Journal Article
In: International Journal of Pharmaceutical and Biological Research , vol. 14, iss. 2, pp. 206-211, 2026, ISSN: 2320-9267.
@article{Siddiqua_2026,
title = {Role of serum D-dimer in early prediction of organ failure in acute pancreatitis: a retrospective study},
author = {Arshiya Siddiqua and Swarna Anupama and Ramakanth Reddy and Chittuluri Jagadeesh},
url = {https://ijpbr.in/index.php/IJPBR/article/view/1222/753},
doi = {10.30750/ijpbr.14.2.36 },
issn = {2320-9267},
year = {2026},
date = {2026-06-09},
urldate = {2026-06-09},
journal = {International Journal of Pharmaceutical and Biological Research },
volume = {14},
issue = {2},
pages = {206-211},
abstract = {Background: Acute pancreatitis (AP) is a common gastrointestinal emergency with clinical outcomes ranging from mild self-limiting disease to severe systemic inflammation and multi-organ dysfunction. Early identification of patients at risk of organ failure remains essential for timely intervention. Serum D-dimer, a degradation product of cross-linked fibrin, has emerged as a potential biomarker reflecting activation of coagulation and inflammatory pathways.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Acute pancreatitis (AP) is a common gastrointestinal emergency with clinical outcomes ranging from mild self-limiting disease to severe systemic inflammation and multi-organ dysfunction. Early identification of patients at risk of organ failure remains essential for timely intervention. Serum D-dimer, a degradation product of cross-linked fibrin, has emerged as a potential biomarker reflecting activation of coagulation and inflammatory pathways.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.
Objective: To evaluate the role of serum D-dimer in early prediction of organ failure among patients with acute pancreatitis.
Methods: A retrospective observational study was conducted among 69 patients diagnosed with acute pancreatitis admitted between July 2020 and November 2021 at a tertiary care center in Hyderabad. Demographic details, laboratory parameters, D-dimer levels, clinical severity, and occurrence of organ failure were analyzed. Statistical analysis included independent t-test, chi-square test, logistic regression, and ROC analysis.
Results: Among 69 patients, organ failure developed in 21 (30.4%) patients. Mean serum D-dimer levels were significantly higher among patients developing organ failure compared to those without organ failure (3.72 ± 1.41 vs 1.58 ± 0.82 μg/mL; p<0.001). ROC analysis demonstrated an AUC of 0.86 with an optimal cut-off value of 2.45 μg/mL showing sensitivity of 81.0% and specificity of 79.2%.
Conclusion: Elevated serum D-dimer may serve as an early predictor of organ failure in acute pancreatitis and may assist clinicians in risk stratification during early hospitalization.
Adil, Mohammed Abdul Majid; Raj, Yeershetty Goutham; Begum, Rabiya
Diagnostic yield of urine cytology compared with cystoscopy in bladder cancer follow-up Journal Article
In: European Journal of Clinical Pharmacy, vol. 8, iss. 1, pp. 3298-3301, 2026, ISSN: 2385-409X.
@article{Adil_2026,
title = {Diagnostic yield of urine cytology compared with cystoscopy in bladder cancer follow-up},
author = {Mohammed Abdul Majid Adil and Yeershetty Goutham Raj and Rabiya Begum},
url = {http://files.farmclin.com/testarticle/1779442159744-EMRN4180.pdf},
doi = {10.61336/ejcp/26-08-410},
issn = {2385-409X},
year = {2026},
date = {2026-05-21},
urldate = {2026-05-21},
journal = {European Journal of Clinical Pharmacy},
volume = {8},
issue = {1},
pages = {3298-3301},
abstract = {Bladder cancer is characterized by high recurrence rates, necessitating rigorous follow-up. Cystoscopy remains the gold standard, while urine cytology offers a non-invasive alternative. However, their comparative diagnostic utility remains debated.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bladder cancer is characterized by high recurrence rates, necessitating rigorous follow-up. Cystoscopy remains the gold standard, while urine cytology offers a non-invasive alternative. However, their comparative diagnostic utility remains debated.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.
Objective:To evaluate the diagnostic yield of urine cytology compared with cystoscopy in follow-up of bladder cancer patients.
Methods:This study was conducted at a tertiary care center including 135 patients under follow-up for bladder cancer. All patients underwent urine cytology and cystoscopy. Histopathology (where applicable) served as confirmatory reference. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy were calculated.
Results:Out of 135 patients, recurrence was detected in 42 cases (31.1%) by cystoscopy. Urine cytology detected 20 cases. Sensitivity, specificity, PPV, NPV, and accuracy of cytology were 47.6%, 97.8%, 90.9%, 80.5%, and 82.2%, respectively. Cystoscopy showed significantly higher sensitivity (p < 0.001).
Conclusion:Urine cytology demonstrates high specificity but low sensitivity compared to cystoscopy. It serves as an adjunct rather than a replacement for cystoscopy in follow-up protocols.
Raj, Yeershetty Goutham; Adil, Mohammed Abdul Majid; Goud, P. Umesh Chandran
In: CME Journal of Geriatric Medicine, vol. 18, iss. 4, pp. 271-274, 2026, ISSN: 1475-1453.
@article{Raj_2026,
title = {Assessment of intravesical prostatic protrusion and its association with severity of lower urinary tract symptoms in benign prostatic hyperplasia: a prospective observational study},
author = {Yeershetty Goutham Raj and Mohammed Abdul Majid Adil and P. Umesh Chandran Goud},
url = {https://cmegeriatricmed.co.uk/article/assessment-of-intravesical-prostatic-protrusion-and-its-association-with-severity-of-lower-urinary-tract-symptoms-in-benign-prostatic-hyperplasia-a-prospective-observational-study--1514/},
doi = {10.61336/cmejgm/2026-04-42},
issn = {1475-1453},
year = {2026},
date = {2026-04-25},
urldate = {2026-04-25},
journal = {CME Journal of Geriatric Medicine},
volume = {18},
issue = {4},
pages = {271-274},
abstract = {Introduction: Benign prostatic hyperplasia (BPH) is a prevalent condition in the aging male population and represents a significant cause of lower urinary tract symptoms. Intravesical prostatic protrusion (IPP) is gaining importance as a non-invasive marker for predicting bladder outlet obstruction and clinical severity.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Benign prostatic hyperplasia (BPH) is a prevalent condition in the aging male population and represents a significant cause of lower urinary tract symptoms. Intravesical prostatic protrusion (IPP) is gaining importance as a non-invasive marker for predicting bladder outlet obstruction and clinical severity.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.
Objective: To evaluate the relationship between intravesical prostatic protrusion and the severity of lower urinary tract symptoms in patients with BPH.
Methods: The study was carried out at a tertiary care center over a period of 12 months. A total of 120 male patients diagnosed with BPH were included. IPP was measured using transabdominal ultrasonography and graded into three categories. LUTS severity was assessed using the International Prostate Symptom Score (IPSS). Statistical analysis included ANOVA and Pearson correlation.
Results: A significant positive correlation was observed between IPP grade and IPSS score (r = 0.68, p < 0.001). Mean IPSS increased progressively from Grade I (8.2 ± 3.1) to Grade III (22.5 ± 4.6). Patients with higher IPP grades had significantly increased post-void residual volume (p < 0.001).
Conclusion: Intravesical prostatic protrusion is strongly associated with the severity of LUTS and can serve as a reliable, non-invasive predictor in BPH patients.
Reddy, S. Chandra; Golla, Abhishek; Zoheb, Mohammed; Bhat, Rama
Clinical profile of acute pulmonary thromboembolism and prognostic value of troponin-T and sPESI in acute pulmonary thromboembolism Journal Article
In: International Journal of Medicine and Public Health, vol. 16, iss. 2, pp. 1357-1363, 2026, ISSN: 2230-8598.
@article{Reddy_2026,
title = {Clinical profile of acute pulmonary thromboembolism and prognostic value of troponin-T and sPESI in acute pulmonary thromboembolism},
author = {S. Chandra Reddy and Abhishek Golla and Mohammed Zoheb and Rama Bhat},
url = {https://www.ijmedph.org/Uploads/Volume16Issue2/227_4934_IJMEDPH_S_Chandra_Reddy_1357_1363.pdf},
doi = {10.70034/ijmedph.2026.2.227},
issn = {2230-8598},
year = {2026},
date = {2026-04-09},
urldate = {2026-04-09},
journal = {International Journal of Medicine and Public Health},
volume = {16},
issue = {2},
pages = {1357-1363},
abstract = {Background: Venous thromboembolism (VTE) is common with high recurrence rates. Even though it is lethal, it is overlooked. It is associated with long term complications. For India, large-scale studies are lacking In view of
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Venous thromboembolism (VTE) is common with high recurrence rates. Even though it is lethal, it is overlooked. It is associated with long term complications. For India, large-scale studies are lacking In view of
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.
limited data availability on the clinical prognostication markers of patients with VTE, present study was carried out to study the clinical profile of the patients admitted with pulmonary thromboembolism and also to evaluate certain serum and clinical prognostic indicators.
Materials and Methods: Hospital-based cross-sectional study was carried out among 61 cases with pulmonary thromboembolism. Details were collected in proforma including clinical characteristics, lab parameters, treatment received. Predefined proforma was used for collecting data on patient age, sex, and outpatient or inpatient status at the time of PE diagnosis, clinical presentation, haemodynamic parameters, comorbidities, risk factors for venous thromboembolism (VTE) and bleeding, detailed risk stratification test results based on Simplified Pulmonary Embolism Severity Index score(sPESI), and treatment modalities. In addition, clinical outcomes were captured.
Results: Median age was 48yrs. Male to Female ratio was 1.44:1. Most common presenting complaint was breathlessness (86.9%). Most common sign was tachypnoea (86.8%). Signs of DVT were present in 49.1%. Most common malignancy was Ovarian malignancy (4.9%). Most common ECG feature was sinus tachycardia (80.3%). DVT was seen in 64%. Those with high trop T levels had significantly high chances of RV dysfunction (p<0.05). 14 patients underwent thrombolysis. 52 cases survived and all-cause mortality was 14.76%. Association between trop T and survival was not significant (p>0.05).
Conclusion: Trop T is a reliable marker for RV dysfunction and may reflect the severity of embolism. Patients with low sPESI score have a better outcome.
Ali, Shireen Adeeb Mujtaba
Revisiting perceptual distortions in the age of generative artificial intelligence: A modern perspective on “Alice in Wonderland Syndrome” Journal Article
In: SBV Journal of Basic, Clinical and Applied Health Science, vol. 9, iss. 2, pp. 157–158, 2026, ISSN: 2581-6039.
@article{Ali_2026d,
title = {Revisiting perceptual distortions in the age of generative artificial intelligence: A modern perspective on “Alice in Wonderland Syndrome”},
author = {Shireen Adeeb Mujtaba Ali},
url = {https://www.ovid.com/jnls/sbvj/fulltext/10.4103/sbvj.sbvj_72_25~revisiting-perceptual-distortions-in-the-age-of-generative},
doi = {10.4103/sbvj.sbvj_72_25},
issn = {2581-6039},
year = {2026},
date = {2026-04-01},
urldate = {2026-04-01},
journal = {SBV Journal of Basic, Clinical and Applied Health Science},
volume = {9},
issue = {2},
pages = {157–158},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Begum, Vaseemunnisa; Fatima, Syeda Aqeelah; Farheen, Humaira; Sadiq, Neeraj; Subhani, Ghulam; Gulnaaz, Syeda Asma
Impact of pharmacovigilance training on knowledge, attitude and practice among pharmacy students- a cross-sectional study. Journal Article
In: Al Ameen Journal of Medical Sciences, vol. 19, iss. 2, pp. 104-110, 2026, ISSN: 0974-1143.
@article{Begum_2026b,
title = {Impact of pharmacovigilance training on knowledge, attitude and practice among pharmacy students- a cross-sectional study.},
author = {Vaseemunnisa Begum and Syeda Aqeelah Fatima and Humaira Farheen and Neeraj Sadiq and Ghulam Subhani and Syeda Asma Gulnaaz},
issn = {0974-1143},
year = {2026},
date = {2026-04-01},
urldate = {2026-04-01},
journal = {Al Ameen Journal of Medical Sciences},
volume = {19},
issue = {2},
pages = {104-110},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Shreen, Sara; Ali, Mazher; Eram, Syeda Lubna; Baig, Mahreen; Nayeem, Mohammed Abdul; Omer, Waheed Fatima Asna; Nasirabadi, Minhajzafar; Hussain, Syed Altaf
Metformin for the management and prevention of antipsychotic‑induced weight gain Journal Article
In: Medicine International, vol. 6, iss. 3, no. 28, 2026, ISSN: 2754-1304.
@article{Shreen_2026,
title = {Metformin for the management and prevention of antipsychotic‑induced weight gain},
author = { Sara Shreen and Mazher Ali and Syeda Lubna Eram and Mahreen Baig and Mohammed Abdul Nayeem and Waheed Fatima Asna Omer and Minhajzafar Nasirabadi and Syed Altaf Hussain},
url = {https://www.spandidos-publications.com/10.3892/mi.2026.312},
doi = {10.3892/mi.2026.312},
issn = {2754-1304},
year = {2026},
date = {2026-03-30},
urldate = {2026-03-01},
journal = {Medicine International},
volume = {6},
number = {28},
issue = {3},
publisher = {Spandidos Publications},
abstract = {Psychiatric disorders are commonly treated with antipsychotic medications; however, their use is frequently complicated by antipsychotic‑associated weight gain (AAWG), which contributes to reduced treatment adherence and an increased cardiometabolic risk. Metformin, an insulin‑sensitizing agent widely used in the management of diabetes, has emerged as a potential adjunctive therapy for mitigating AAWG, although real‑world clinical data remain limited. The present prospective observational study evaluated the effectiveness of adjunctive metformin therapy in the management of AAWG in a routine psychiatric care setting. The present study was conducted over a period of 6 months and included 100 adult patients receiving antipsychotic treatment. Participants were allocated into two groups based on routine clinical practice: A test group receiving metformin in addition to antipsychotic therapy and lifestyle modifications (n=50), and a control group receiving antipsychotic therapy with lifestyle modifications alone (n=50). Changes in body weight and body mass index (BMI) were assessed as primary outcomes. The study population predominantly comprised younger adults aged 18‑29 years, with a higher proportion of female patients. Olanzapine was the most frequently prescribed antipsychotic, and schizophrenia was the most common psychiatric diagnosis. The test group demonstrated a reduction in mean body weight and BMI over the study period, whereas the control group exhibited an increase in both parameters. Female patients reported a greater adherence to metformin therapy; however, adherence was assessed using self‑reports and pill counts. These findings suggest that adjunctive metformin therapy may be associated with improvements in weight‑related outcomes among patients receiving antipsychotics. Given the observational and non‑randomized design, the results should be interpreted with caution, and further randomized controlled studies are warranted to confirm the long‑term metabolic benefits.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Psychiatric disorders are commonly treated with antipsychotic medications; however, their use is frequently complicated by antipsychotic‑associated weight gain (AAWG), which contributes to reduced treatment adherence and an increased cardiometabolic risk. Metformin, an insulin‑sensitizing agent widely used in the management of diabetes, has emerged as a potential adjunctive therapy for mitigating AAWG, although real‑world clinical data remain limited. The present prospective observational study evaluated the effectiveness of adjunctive metformin therapy in the management of AAWG in a routine psychiatric care setting. The present study was conducted over a period of 6 months and included 100 adult patients receiving antipsychotic treatment. Participants were allocated into two groups based on routine clinical practice: A test group receiving metformin in addition to antipsychotic therapy and lifestyle modifications (n=50), and a control group receiving antipsychotic therapy with lifestyle modifications alone (n=50). Changes in body weight and body mass index (BMI) were assessed as primary outcomes. The study population predominantly comprised younger adults aged 18‑29 years, with a higher proportion of female patients. Olanzapine was the most frequently prescribed antipsychotic, and schizophrenia was the most common psychiatric diagnosis. The test group demonstrated a reduction in mean body weight and BMI over the study period, whereas the control group exhibited an increase in both parameters. Female patients reported a greater adherence to metformin therapy; however, adherence was assessed using self‑reports and pill counts. These findings suggest that adjunctive metformin therapy may be associated with improvements in weight‑related outcomes among patients receiving antipsychotics. Given the observational and non‑randomized design, the results should be interpreted with caution, and further randomized controlled studies are warranted to confirm the long‑term metabolic benefits.
Ayesha, Syeda; Nahidunnisa, Syeda; Ghouse, Heeba Mohammed; Shaikh, Humaira
Total thyroidectomy versus hemithyroidectomy: a comparative study of complications and surgical outcomes Journal Article
In: International Journal of Current Pharmaceutical Review and Research, vol. 18, iss. 4, pp. 492-496, 2026, ISSN: 0976-822X.
@article{Ayesha_2026,
title = {Total thyroidectomy versus hemithyroidectomy: a comparative study of complications and surgical outcomes},
author = {Syeda Ayesha and Syeda Nahidunnisa and Heeba Mohammed Ghouse and Humaira Shaikh},
url = {https://impactfactor.org/PDF/IJCPR/18/IJCPR,Vol18,Issue4,Article80.pdf},
doi = {10.25258/ijcpr.18.4.80},
issn = {0976-822X},
year = {2026},
date = {2026-03-21},
urldate = {2026-03-21},
journal = {International Journal of Current Pharmaceutical Review and Research},
volume = {18},
issue = {4},
pages = {492-496},
abstract = {Introduction: Thyroidectomy is a commonly performed surgical procedure for the management of benign and malignant thyroid disorders. The two principal approaches, total thyroidectomy and hemithyroidectomy, differ in extent of resection and are associated with varying complication profiles. Understanding these differences is essential for optimal surgical decision-making. The study aimed to compare the complication rates between total thyroidectomy and hemithyroidectomy and to evaluate associated operative and postoperative outcomes. Materials and Methods: This hospital-based comparative observational study was conducted in the Department of ENT and Head and Neck Surgery at Deccan College of Medical Sciences, Hyderabad, from January 2025 to December 2025. A total of 50 patients undergoing thyroid surgery were included and divided into two groups: total thyroidectomy (n=25) and hemithyroidectomy (n=25). Demographic and clinical variables were recorded. Postoperative complications including hypocalcaemia, recurrent laryngeal nerve injury, haemorrhage, and wound infection were assessed. Statistical analysis was performed using SPSS version 26.0, with p<0.05 considered significant. Results: The overall complication rate was significantly higher in the total thyroidectomy group (44.0%) compared to the hemithyroidectomy group (20.0%) (p=0.04). Transient hypocalcaemia was significantly more frequent following total thyroidectomy (32.0% vs. 4.0%, p=0.01). No significant differences were observed in permanent hypocalcaemia, recurrent laryngeal nerve injury, hemorrhage, or wound infection. The mean duration of surgery and hospital stay were significantly higher in the total thyroidectomy group (p<0.001). Conclusion: Total thyroidectomy is associated with a higher complication rate, particularly hypocalcaemia, along with increased operative time and hospital stay compared to hemithyroidectomy. Careful patient selection and surgical planning are essential to balance treatment efficacy and safety.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Thyroidectomy is a commonly performed surgical procedure for the management of benign and malignant thyroid disorders. The two principal approaches, total thyroidectomy and hemithyroidectomy, differ in extent of resection and are associated with varying complication profiles. Understanding these differences is essential for optimal surgical decision-making. The study aimed to compare the complication rates between total thyroidectomy and hemithyroidectomy and to evaluate associated operative and postoperative outcomes. Materials and Methods: This hospital-based comparative observational study was conducted in the Department of ENT and Head and Neck Surgery at Deccan College of Medical Sciences, Hyderabad, from January 2025 to December 2025. A total of 50 patients undergoing thyroid surgery were included and divided into two groups: total thyroidectomy (n=25) and hemithyroidectomy (n=25). Demographic and clinical variables were recorded. Postoperative complications including hypocalcaemia, recurrent laryngeal nerve injury, haemorrhage, and wound infection were assessed. Statistical analysis was performed using SPSS version 26.0, with p<0.05 considered significant. Results: The overall complication rate was significantly higher in the total thyroidectomy group (44.0%) compared to the hemithyroidectomy group (20.0%) (p=0.04). Transient hypocalcaemia was significantly more frequent following total thyroidectomy (32.0% vs. 4.0%, p=0.01). No significant differences were observed in permanent hypocalcaemia, recurrent laryngeal nerve injury, hemorrhage, or wound infection. The mean duration of surgery and hospital stay were significantly higher in the total thyroidectomy group (p<0.001). Conclusion: Total thyroidectomy is associated with a higher complication rate, particularly hypocalcaemia, along with increased operative time and hospital stay compared to hemithyroidectomy. Careful patient selection and surgical planning are essential to balance treatment efficacy and safety.
Vadthya, Ganesh; Jarupla, Srikanth N.; Naik, Ajit K.; Tiwari, Rahul; Managutti, Anil; Gupta, Seema
Laparoscopic versus open cholecystectomy in gangrenous cholecystitis: a retrospective comparative study Journal Article
In: Cureus, vol. 18, iss. 3, pp. e104682, 2026, ISSN: 2168-8184.
@article{Vadthya_2026,
title = {Laparoscopic versus open cholecystectomy in gangrenous cholecystitis: a retrospective comparative study},
author = {Ganesh Vadthya and Srikanth N. Jarupla and Ajit K. Naik and Rahul Tiwari and Anil Managutti and Seema Gupta},
url = {https://assets.cureus.com/uploads/original_article/pdf/467424/20260305-335444-dg373w.pdf},
doi = {10.7759/cureus.104682},
issn = {2168-8184},
year = {2026},
date = {2026-03-04},
urldate = {2026-03-04},
journal = {Cureus},
volume = {18},
issue = {3},
pages = {e104682},
abstract = {Introduction: Gangrenous cholecystitis (GC) is a severe form of acute cholecystitis associated with increased operative difficulty and postoperative morbidity. Although open cholecystectomy is traditionally preferred, advances in minimally invasive surgery have expanded the role of laparoscopy. However, the optimal surgical approach to GC remains controversial. This study aimed to compare the perioperative and postoperative outcomes of laparoscopic and open cholecystectomy in patients with GC.
Materials and methods: This retrospective observational study was conducted at the Department of General Surgery at Deccan College of Medical Sciences, a tertiary care cente in Hyderabad, India. It included adult patients with intraoperatively confirmed GC who underwent laparoscopic or open cholecystectomy at a tertiary care center over a two-year period. Demographic data, operative parameters, intraoperative complications, postoperative morbidity, and length of hospital stay were analyzed and compared between groups.
Results: Seventy-nine patients were included, of which 34 underwent laparoscopic cholecystectomy and 45 underwent open cholecystectomy. Baseline demographic and clinical characteristics were comparable between the groups. The mean operative time was significantly longer in the laparoscopic group (98.5 ± 25.4 min) than in the open group (86.2 ± 22.1 min; p = 0.023). The intraoperative complication rates were similar (p = 0.87). Conversion to open surgery occurred in eight (23.5%) laparoscopic cases. The total number of postoperative complications showed a non-significant reduction following laparoscopic cholecystectomy (p = 0.052), not meeting the predefined threshold for statistical significance (p < 0.05). The median hospital stay was shorter in the laparoscopic group (6 vs. 8 days, p = 0.039).
Conclusion: Laparoscopic cholecystectomy is a safe and feasible option for GC, offering shorter hospital stay despite a longer operative time. A laparoscopic-first approach, with a low threshold for conversion, is recommended for appropriately selected patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Gangrenous cholecystitis (GC) is a severe form of acute cholecystitis associated with increased operative difficulty and postoperative morbidity. Although open cholecystectomy is traditionally preferred, advances in minimally invasive surgery have expanded the role of laparoscopy. However, the optimal surgical approach to GC remains controversial. This study aimed to compare the perioperative and postoperative outcomes of laparoscopic and open cholecystectomy in patients with GC.
Materials and methods: This retrospective observational study was conducted at the Department of General Surgery at Deccan College of Medical Sciences, a tertiary care cente in Hyderabad, India. It included adult patients with intraoperatively confirmed GC who underwent laparoscopic or open cholecystectomy at a tertiary care center over a two-year period. Demographic data, operative parameters, intraoperative complications, postoperative morbidity, and length of hospital stay were analyzed and compared between groups.
Results: Seventy-nine patients were included, of which 34 underwent laparoscopic cholecystectomy and 45 underwent open cholecystectomy. Baseline demographic and clinical characteristics were comparable between the groups. The mean operative time was significantly longer in the laparoscopic group (98.5 ± 25.4 min) than in the open group (86.2 ± 22.1 min; p = 0.023). The intraoperative complication rates were similar (p = 0.87). Conversion to open surgery occurred in eight (23.5%) laparoscopic cases. The total number of postoperative complications showed a non-significant reduction following laparoscopic cholecystectomy (p = 0.052), not meeting the predefined threshold for statistical significance (p < 0.05). The median hospital stay was shorter in the laparoscopic group (6 vs. 8 days, p = 0.039).
Conclusion: Laparoscopic cholecystectomy is a safe and feasible option for GC, offering shorter hospital stay despite a longer operative time. A laparoscopic-first approach, with a low threshold for conversion, is recommended for appropriately selected patients.
Materials and methods: This retrospective observational study was conducted at the Department of General Surgery at Deccan College of Medical Sciences, a tertiary care cente in Hyderabad, India. It included adult patients with intraoperatively confirmed GC who underwent laparoscopic or open cholecystectomy at a tertiary care center over a two-year period. Demographic data, operative parameters, intraoperative complications, postoperative morbidity, and length of hospital stay were analyzed and compared between groups.
Results: Seventy-nine patients were included, of which 34 underwent laparoscopic cholecystectomy and 45 underwent open cholecystectomy. Baseline demographic and clinical characteristics were comparable between the groups. The mean operative time was significantly longer in the laparoscopic group (98.5 ± 25.4 min) than in the open group (86.2 ± 22.1 min; p = 0.023). The intraoperative complication rates were similar (p = 0.87). Conversion to open surgery occurred in eight (23.5%) laparoscopic cases. The total number of postoperative complications showed a non-significant reduction following laparoscopic cholecystectomy (p = 0.052), not meeting the predefined threshold for statistical significance (p < 0.05). The median hospital stay was shorter in the laparoscopic group (6 vs. 8 days, p = 0.039).
Conclusion: Laparoscopic cholecystectomy is a safe and feasible option for GC, offering shorter hospital stay despite a longer operative time. A laparoscopic-first approach, with a low threshold for conversion, is recommended for appropriately selected patients.
Jarupla, Srikanth N.; Vadthya, Ganesh; Naik, Ajit K.; Dixit, Heena; Pillai, Prashant; Managutti, Anil; Gupta, Seema
In: Cureus, vol. 18, iss. 3, pp. e104487, 2026, ISSN: 2168-8184.
@article{Jarupla_2026,
title = {Comparative outcomes of transabdominal preperitoneal and totally extraperitoneal laparoscopic inguinal hernia repair: a retrospective cohort study},
author = {Srikanth N. Jarupla and Ganesh Vadthya and Ajit K. Naik and Heena Dixit and Prashant Pillai and Anil Managutti and Seema Gupta},
url = {https://assets.cureus.com/uploads/original_article/pdf/466996/20260301-75314-70i5kz.pdf},
doi = {10.7759/cureus.104487},
issn = {2168-8184},
year = {2026},
date = {2026-03-01},
urldate = {2026-03-01},
journal = {Cureus},
volume = {18},
issue = {3},
pages = {e104487},
abstract = {Introduction: Laparoscopic inguinal hernia repair is widely performed using either the transabdominal
preperitoneal (TAPP) or totally extraperitoneal (TEP) approach. Although both techniques are established,
uncertainty persists regarding their relative perioperative and postoperative outcomes in routine clinical
practice. The aim of the present study was to compare operative parameters, postoperative recovery,
complication rates, and short-term outcomes between TAPP and TEP laparoscopic inguinal hernia repair.
Materials and methods: This retrospective cohort study included 100 adult patients who underwent elective
laparoscopic inguinal hernia repair between August 2021 and April 2023. Patients were equally divided into
TAPP (n = 50) and TEP (n = 50) groups. Demographic characteristics, operative details, postoperative pain,
length of hospital stay, intraoperative conversion, complications, and follow-up outcomes were analyzed.
Continuous variables were compared using independent samples t-tests, and categorical variables were
analyzed using Fisher's exact or chi-squared tests.
Results: Baseline demographic and hernia-related characteristics were comparable between the groups. A
significantly higher intraoperative conversion rate was observed in the TEP group. Operative time,
postoperative pain scores, and hospital stay did not differ significantly between techniques. Rates of short-
term complications, including seroma, infection, and urinary retention, were similar. Short-term outcomes,
including recurrence and chronic groin pain, showed no statistically significant differences during follow-
up.
Conclusion: Both TAPP and TEP laparoscopic inguinal hernia repairs demonstrated comparable safety and
effectiveness. However, the higher conversion rate associated with TEP highlights its technical complexity.
Technique selection should be guided by surgeon experience, patient factors, and institutional expertise.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Laparoscopic inguinal hernia repair is widely performed using either the transabdominal
preperitoneal (TAPP) or totally extraperitoneal (TEP) approach. Although both techniques are established,
uncertainty persists regarding their relative perioperative and postoperative outcomes in routine clinical
practice. The aim of the present study was to compare operative parameters, postoperative recovery,
complication rates, and short-term outcomes between TAPP and TEP laparoscopic inguinal hernia repair.
Materials and methods: This retrospective cohort study included 100 adult patients who underwent elective
laparoscopic inguinal hernia repair between August 2021 and April 2023. Patients were equally divided into
TAPP (n = 50) and TEP (n = 50) groups. Demographic characteristics, operative details, postoperative pain,
length of hospital stay, intraoperative conversion, complications, and follow-up outcomes were analyzed.
Continuous variables were compared using independent samples t-tests, and categorical variables were
analyzed using Fisher's exact or chi-squared tests.
Results: Baseline demographic and hernia-related characteristics were comparable between the groups. A
significantly higher intraoperative conversion rate was observed in the TEP group. Operative time,
postoperative pain scores, and hospital stay did not differ significantly between techniques. Rates of short-
term complications, including seroma, infection, and urinary retention, were similar. Short-term outcomes,
including recurrence and chronic groin pain, showed no statistically significant differences during follow-
up.
Conclusion: Both TAPP and TEP laparoscopic inguinal hernia repairs demonstrated comparable safety and
effectiveness. However, the higher conversion rate associated with TEP highlights its technical complexity.
Technique selection should be guided by surgeon experience, patient factors, and institutional expertise.
preperitoneal (TAPP) or totally extraperitoneal (TEP) approach. Although both techniques are established,
uncertainty persists regarding their relative perioperative and postoperative outcomes in routine clinical
practice. The aim of the present study was to compare operative parameters, postoperative recovery,
complication rates, and short-term outcomes between TAPP and TEP laparoscopic inguinal hernia repair.
Materials and methods: This retrospective cohort study included 100 adult patients who underwent elective
laparoscopic inguinal hernia repair between August 2021 and April 2023. Patients were equally divided into
TAPP (n = 50) and TEP (n = 50) groups. Demographic characteristics, operative details, postoperative pain,
length of hospital stay, intraoperative conversion, complications, and follow-up outcomes were analyzed.
Continuous variables were compared using independent samples t-tests, and categorical variables were
analyzed using Fisher's exact or chi-squared tests.
Results: Baseline demographic and hernia-related characteristics were comparable between the groups. A
significantly higher intraoperative conversion rate was observed in the TEP group. Operative time,
postoperative pain scores, and hospital stay did not differ significantly between techniques. Rates of short-
term complications, including seroma, infection, and urinary retention, were similar. Short-term outcomes,
including recurrence and chronic groin pain, showed no statistically significant differences during follow-
up.
Conclusion: Both TAPP and TEP laparoscopic inguinal hernia repairs demonstrated comparable safety and
effectiveness. However, the higher conversion rate associated with TEP highlights its technical complexity.
Technique selection should be guided by surgeon experience, patient factors, and institutional expertise.
Akhtar, Mohtashim Idrees; Tazeen, Naushaba; Tabassum, Jasmine; Afroze, Idrees Akhtar
Occult male breast cancer presenting as axillary lymphadenopathy: a rare case report Journal Article
In: Surgical and Experimental Pathology, vol. 9, pp. 1-11, 2026, ISSN: 2520-8454.
@article{Akhtar_2026,
title = {Occult male breast cancer presenting as axillary lymphadenopathy: a rare case report},
author = {Mohtashim Idrees Akhtar and Naushaba Tazeen and Jasmine Tabassum and Idrees Akhtar Afroze},
url = {https://link.springer.com/article/10.1186/s42047-026-00225-8},
doi = {10.1186/s42047-026-00225-8 },
issn = {2520-8454},
year = {2026},
date = {2026-02-20},
urldate = {2026-02-20},
journal = {Surgical and Experimental Pathology},
volume = {9},
pages = {1-11},
abstract = {Background: Male breast cancer (MBC) is a rare condition in the spectrum of breast cancer. It is most commonly diagnosed in men between the ages of 60 and 70, with an average age of 67 at diagnosis. MBC accounts for less than 1% of all breast cancer cases, with incidence varying across ethnic groups. Rates are highest among non-Hispanic Black men (1.89 per 100,000). Elevated incidence in South and Central Africa may be linked to hyperestrogenism from liver infections. Occult male breast cancer is extremely rare, accounting for only 0.3%–1% of all cases of breast cancer. Genetic predispositions, especially BRCA2 mutations, significantly increase the risk of MBC greater than BRCA1 mutations. The most frequent histological type is infiltrating ductal carcinoma, while invasive lobular carcinoma is exceptionally uncommon. MBC tumours are typically hormone receptor-positive. Key risk factors for MBC include older age, black ethnicity, genetic mutations, family history, liver cirrhosis, and testicular disorders. Most patients present with painless breast lumps, and about 50% have lymph node involvement at diagnosis.
Case presentation: A 61-year-old male presented with a 6-year history of non-tender swelling in the left axilla, with no associated systemic symptoms. Clinical examination revealed matted, erythematous lymph nodes, prompting fine needle aspiration and subsequent excision biopsy. Cytology demonstrated markedly atypical tumour cells with a high N: C ratio and significant pleomorphism. Histopathology of the lymph node confirmed effaced architecture with malignant cells arranged in sheets, cords, and cohesive tumour nests, along with capsular invasion. Immunohistochemistry showed CK7 and GATA3 positivity and strong HER2 (3+) expression, while ER, PR, Mammaglobin, and CK20 were negative—findings consistent with metastatic HER2-positive primary breast carcinoma. Positron emission tomography imaging revealed metabolically active axillary and deep pectoral nodes. The patient received neoadjuvant chemotherapy with docetaxel, carboplatin, trastuzumab, and filgrastim, followed by modified radical mastectomy with the breast parenchyma showing ypT0, ypN1a post 4 cycles of NACT.
Conclusion: This case highlights the diagnostic challenges of male breast cancer, particularly when presenting solely as axillary lymphadenopathy. Immunohistochemistry and positron emission tomography play an essential role in establishing diagnosis and staging. Timely neoadjuvant chemotherapy and surgery achieved primary tumour clearance, underscoring the importance of early suspicion, comprehensive evaluation, and guideline-based management of HER2-positive MBC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Male breast cancer (MBC) is a rare condition in the spectrum of breast cancer. It is most commonly diagnosed in men between the ages of 60 and 70, with an average age of 67 at diagnosis. MBC accounts for less than 1% of all breast cancer cases, with incidence varying across ethnic groups. Rates are highest among non-Hispanic Black men (1.89 per 100,000). Elevated incidence in South and Central Africa may be linked to hyperestrogenism from liver infections. Occult male breast cancer is extremely rare, accounting for only 0.3%–1% of all cases of breast cancer. Genetic predispositions, especially BRCA2 mutations, significantly increase the risk of MBC greater than BRCA1 mutations. The most frequent histological type is infiltrating ductal carcinoma, while invasive lobular carcinoma is exceptionally uncommon. MBC tumours are typically hormone receptor-positive. Key risk factors for MBC include older age, black ethnicity, genetic mutations, family history, liver cirrhosis, and testicular disorders. Most patients present with painless breast lumps, and about 50% have lymph node involvement at diagnosis.
Case presentation: A 61-year-old male presented with a 6-year history of non-tender swelling in the left axilla, with no associated systemic symptoms. Clinical examination revealed matted, erythematous lymph nodes, prompting fine needle aspiration and subsequent excision biopsy. Cytology demonstrated markedly atypical tumour cells with a high N: C ratio and significant pleomorphism. Histopathology of the lymph node confirmed effaced architecture with malignant cells arranged in sheets, cords, and cohesive tumour nests, along with capsular invasion. Immunohistochemistry showed CK7 and GATA3 positivity and strong HER2 (3+) expression, while ER, PR, Mammaglobin, and CK20 were negative—findings consistent with metastatic HER2-positive primary breast carcinoma. Positron emission tomography imaging revealed metabolically active axillary and deep pectoral nodes. The patient received neoadjuvant chemotherapy with docetaxel, carboplatin, trastuzumab, and filgrastim, followed by modified radical mastectomy with the breast parenchyma showing ypT0, ypN1a post 4 cycles of NACT.
Conclusion: This case highlights the diagnostic challenges of male breast cancer, particularly when presenting solely as axillary lymphadenopathy. Immunohistochemistry and positron emission tomography play an essential role in establishing diagnosis and staging. Timely neoadjuvant chemotherapy and surgery achieved primary tumour clearance, underscoring the importance of early suspicion, comprehensive evaluation, and guideline-based management of HER2-positive MBC.
Case presentation: A 61-year-old male presented with a 6-year history of non-tender swelling in the left axilla, with no associated systemic symptoms. Clinical examination revealed matted, erythematous lymph nodes, prompting fine needle aspiration and subsequent excision biopsy. Cytology demonstrated markedly atypical tumour cells with a high N: C ratio and significant pleomorphism. Histopathology of the lymph node confirmed effaced architecture with malignant cells arranged in sheets, cords, and cohesive tumour nests, along with capsular invasion. Immunohistochemistry showed CK7 and GATA3 positivity and strong HER2 (3+) expression, while ER, PR, Mammaglobin, and CK20 were negative—findings consistent with metastatic HER2-positive primary breast carcinoma. Positron emission tomography imaging revealed metabolically active axillary and deep pectoral nodes. The patient received neoadjuvant chemotherapy with docetaxel, carboplatin, trastuzumab, and filgrastim, followed by modified radical mastectomy with the breast parenchyma showing ypT0, ypN1a post 4 cycles of NACT.
Conclusion: This case highlights the diagnostic challenges of male breast cancer, particularly when presenting solely as axillary lymphadenopathy. Immunohistochemistry and positron emission tomography play an essential role in establishing diagnosis and staging. Timely neoadjuvant chemotherapy and surgery achieved primary tumour clearance, underscoring the importance of early suspicion, comprehensive evaluation, and guideline-based management of HER2-positive MBC.
Atharuddin, Athar Mohammed; Ponnapalli, Yasaswi
In: International Journal of Medicine, vol. 8, iss. 1, pp. 127-133, 2026, ISSN: 1468-3814.
@article{Atharuddin_2026,
title = {An observational study to assess the effectiveness of intermittent vs continuous negative pressure wound therapy in the healing of diabetic foot ulcers},
author = {Athar Mohammed Atharuddin and Yasaswi Ponnapalli},
url = {https://app.theinternationalmedicine.com/public/testarticle/pdfFile-1771181250710-421183918.pdf},
doi = {10.61336/im/26-2-19},
issn = {1468-3814},
year = {2026},
date = {2026-02-14},
urldate = {2026-01-28},
journal = {International Journal of Medicine},
volume = {8},
issue = {1},
pages = {127-133},
abstract = {BBackground: Diabetic foot ulcers (DFUs) are among the most serious complications of diabetes mellitus and are associated with delayed wound healing, infection, prolonged hospitalization, and increased risk of lower-limb amputation. Negative pressure wound therapy (NPWT) has emerged as an effective adjunct in DFU management. While continuous NPWT is commonly used, intermittent NPWT has been proposed to enhance wound healing through improved tissue perfusion and cellular stimulation. However, comparative evidence between these two modalities remains limited. Aim of the study was to compare the effectiveness of intermittent versus continuous negative pressure wound therapy in the healing of diabetic foot ulcers with respect to wound contraction, granulation tissue formation, wound closure time, and duration of hospital stay. Materials and Methods: This prospective observational study was conducted over 18 months at a tertiary care center. Sixty patients with Wagner grade 1 and 2 diabetic foot ulcers were enrolled and divided into two groups: Group A (continuous NPWT, n = 30) and Group B (intermittent NPWT, n = 30). After surgical debridement, NPWT was applied at −75 to −125 mmHg either continuously (Group A) or intermittently (1 hour every 3 hours; Group B). Patients were followed up to 12 weeks. Outcomes assessed included wound contraction percentage, time to wound closure, granulation tissue formation, and length of hospital stay. Statistical analysis was performed using IBM SPSS version 24. Results: Baseline characteristics were comparable between the two groups. Wound healing at 12 weeks was higher in the intermittent NPWT group compared to the continuous NPWT group (86.67% vs 73.33%). Intermittent NPWT demonstrated significantly greater wound contraction at 6 weeks (76.63% vs 68.45%, p = 0.001) and 12 weeks (93.84% vs 88.16%, p = 0.01). Mean wound closure time was significantly shorter in the intermittent group (72.65 ± 14.92 days) compared to the continuous group (82.71 ± 16.75 days; p = 0.0001). The duration of hospital stay was slightly shorter in the intermittent group but did not reach statistical significance. Conclusion: Intermittent NPWT is more effective than continuous NPWT in promoting wound contraction and accelerating wound closure in diabetic foot ulcers. It represents a superior modality for optimizing DFU healing outcomes.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BBackground: Diabetic foot ulcers (DFUs) are among the most serious complications of diabetes mellitus and are associated with delayed wound healing, infection, prolonged hospitalization, and increased risk of lower-limb amputation. Negative pressure wound therapy (NPWT) has emerged as an effective adjunct in DFU management. While continuous NPWT is commonly used, intermittent NPWT has been proposed to enhance wound healing through improved tissue perfusion and cellular stimulation. However, comparative evidence between these two modalities remains limited. Aim of the study was to compare the effectiveness of intermittent versus continuous negative pressure wound therapy in the healing of diabetic foot ulcers with respect to wound contraction, granulation tissue formation, wound closure time, and duration of hospital stay. Materials and Methods: This prospective observational study was conducted over 18 months at a tertiary care center. Sixty patients with Wagner grade 1 and 2 diabetic foot ulcers were enrolled and divided into two groups: Group A (continuous NPWT, n = 30) and Group B (intermittent NPWT, n = 30). After surgical debridement, NPWT was applied at −75 to −125 mmHg either continuously (Group A) or intermittently (1 hour every 3 hours; Group B). Patients were followed up to 12 weeks. Outcomes assessed included wound contraction percentage, time to wound closure, granulation tissue formation, and length of hospital stay. Statistical analysis was performed using IBM SPSS version 24. Results: Baseline characteristics were comparable between the two groups. Wound healing at 12 weeks was higher in the intermittent NPWT group compared to the continuous NPWT group (86.67% vs 73.33%). Intermittent NPWT demonstrated significantly greater wound contraction at 6 weeks (76.63% vs 68.45%, p = 0.001) and 12 weeks (93.84% vs 88.16%, p = 0.01). Mean wound closure time was significantly shorter in the intermittent group (72.65 ± 14.92 days) compared to the continuous group (82.71 ± 16.75 days; p = 0.0001). The duration of hospital stay was slightly shorter in the intermittent group but did not reach statistical significance. Conclusion: Intermittent NPWT is more effective than continuous NPWT in promoting wound contraction and accelerating wound closure in diabetic foot ulcers. It represents a superior modality for optimizing DFU healing outcomes.
Fatima, Sarwat; Fatima, Nabila; Kulkarni, Grishma Vijaykumar; Sultana, Shaheen
In: IP International Journal of Medical Microbiology and Tropical Diseases, vol. 12, iss. 1, pp. 103-108, 2026, ISSN: 2581-4753.
@article{Fatima_2026,
title = {Bacteriological profile & antibiotic susceptibility pattern of isolates from endotracheal secretions & bronchoalveolar lavage fluid at a tertiary care hospital – a six-month study},
author = {Sarwat Fatima and Nabila Fatima and Grishma Vijaykumar Kulkarni and Shaheen Sultana},
url = {https://ijmmtd.org/archive/volume/12/issue/1/article/26080/pdf},
doi = {10.18231/j.ijmmtd.14700.1767782742},
issn = {2581-4753},
year = {2026},
date = {2026-02-10},
urldate = {2026-02-10},
journal = {IP International Journal of Medical Microbiology and Tropical Diseases},
volume = {12},
issue = {1},
pages = {103-108},
abstract = {Introduction: Lower respiratory tract infections, especially aspiration pneumonia is very common in hospitalized & critically ill patients on mechanical ventilator.
Aim & Objective: To determine the bacteriological profile and antibiotic susceptibility pattern of the isolates from endotracheal secretions and bronchoalveolar lavage fluid samples obtained from patients who were mechanically ventilated in various ICUs of the hospital.
Materials and Methods: A cross-sectional retrospective study was conducted for six months by analyzing data collected from medical records of patients and microbiology laboratory using R software. The patient inclusion & exclusion criteria were determined as per CPIS score.
Results: around 101 samples were received, and overall culture positivity rate was found as 50/101[49.50%]. The ratio of males was higher in the study for both samples obtained and culture positive specimens. The age range of patients was between <1 year to 90 years with culture positivity being centpercent in 90 years of age. The commonest bacterial isolates were from Enterobacterales as 28/50 [56%] followed by non-fermenters as 19 [38%] and in gram positive bacteria Staphylococcus aureus was isolated in 3/50 (6%) of the specimens. MRSA was isolated in only 1/3 (33%). The antibiotic susceptibility pattern of gram-negative bacilli isolates varied. Carbapenem resistance was less noted in Enterobacteriaceae as between 30-35% compared to non-fermenters as between 44-75%. The single MRSA isolate was sensitive to glycopeptides and oxazolidinones.
Conclusion: Enterobacterales are the predominant isolates in our study followed by non-fermenters with alarming resistance in Acinetobacter baumannii to carbapenems demanding intensified implementation and monitoring of targeted infection control measures in intensive care units.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Lower respiratory tract infections, especially aspiration pneumonia is very common in hospitalized & critically ill patients on mechanical ventilator.
Aim & Objective: To determine the bacteriological profile and antibiotic susceptibility pattern of the isolates from endotracheal secretions and bronchoalveolar lavage fluid samples obtained from patients who were mechanically ventilated in various ICUs of the hospital.
Materials and Methods: A cross-sectional retrospective study was conducted for six months by analyzing data collected from medical records of patients and microbiology laboratory using R software. The patient inclusion & exclusion criteria were determined as per CPIS score.
Results: around 101 samples were received, and overall culture positivity rate was found as 50/101[49.50%]. The ratio of males was higher in the study for both samples obtained and culture positive specimens. The age range of patients was between <1 year to 90 years with culture positivity being centpercent in 90 years of age. The commonest bacterial isolates were from Enterobacterales as 28/50 [56%] followed by non-fermenters as 19 [38%] and in gram positive bacteria Staphylococcus aureus was isolated in 3/50 (6%) of the specimens. MRSA was isolated in only 1/3 (33%). The antibiotic susceptibility pattern of gram-negative bacilli isolates varied. Carbapenem resistance was less noted in Enterobacteriaceae as between 30-35% compared to non-fermenters as between 44-75%. The single MRSA isolate was sensitive to glycopeptides and oxazolidinones.
Conclusion: Enterobacterales are the predominant isolates in our study followed by non-fermenters with alarming resistance in Acinetobacter baumannii to carbapenems demanding intensified implementation and monitoring of targeted infection control measures in intensive care units.
Aim & Objective: To determine the bacteriological profile and antibiotic susceptibility pattern of the isolates from endotracheal secretions and bronchoalveolar lavage fluid samples obtained from patients who were mechanically ventilated in various ICUs of the hospital.
Materials and Methods: A cross-sectional retrospective study was conducted for six months by analyzing data collected from medical records of patients and microbiology laboratory using R software. The patient inclusion & exclusion criteria were determined as per CPIS score.
Results: around 101 samples were received, and overall culture positivity rate was found as 50/101[49.50%]. The ratio of males was higher in the study for both samples obtained and culture positive specimens. The age range of patients was between <1 year to 90 years with culture positivity being centpercent in 90 years of age. The commonest bacterial isolates were from Enterobacterales as 28/50 [56%] followed by non-fermenters as 19 [38%] and in gram positive bacteria Staphylococcus aureus was isolated in 3/50 (6%) of the specimens. MRSA was isolated in only 1/3 (33%). The antibiotic susceptibility pattern of gram-negative bacilli isolates varied. Carbapenem resistance was less noted in Enterobacteriaceae as between 30-35% compared to non-fermenters as between 44-75%. The single MRSA isolate was sensitive to glycopeptides and oxazolidinones.
Conclusion: Enterobacterales are the predominant isolates in our study followed by non-fermenters with alarming resistance in Acinetobacter baumannii to carbapenems demanding intensified implementation and monitoring of targeted infection control measures in intensive care units.
Ali, Shireen Adeeb Mujtaba
Clinical impact of quorum sensing on diabetic foot ulcer Journal Article
In: SBV Journal of Basic, Clinical and Applied Health Science, vol. 9, iss. 1, pp. 53–57, 2026, ISSN: 2581-6039.
@article{Ali_2026,
title = {Clinical impact of quorum sensing on diabetic foot ulcer},
author = { Shireen Adeeb Mujtaba Ali},
url = {https://journals.lww.com/sbvj/fulltext/2026/01000/clinical_impact_of_quorum_sensing_on_diabetic_foot.8.aspx},
doi = {10.4103/sbvj.sbvj_43_25},
issn = {2581-6039},
year = {2026},
date = {2026-01-31},
urldate = {2026-01-01},
journal = {SBV Journal of Basic, Clinical and Applied Health Science},
volume = {9},
issue = {1},
pages = {53–57},
publisher = {Wolters Kluwer Health},
abstract = {Diabetic foot infections are a prevalent side effect of the disease and a concerning public health concern that can have major repercussions, including amputations and even diabetic deaths. Minor foot injuries have a significant chance of developing into potentially fatal infections due to opportunistic microorganisms from the patient’s surroundings. Polymicrobial biofilms commonly found in diabetic foot ulcers (DFUs) use quorum sensing (QS) to coordinate antibiotic tolerance, persistence, and virulence. QS-mediated co-ordination facilitates the formation of extracellular polymeric substance, the expression of proteases and poisons, immunological evasion, and persister cell survival. Clinically, these characteristics increase the likelihood of hospitalization and amputation, stimulate persistent infection, and hinder wound healing. Using inhibitory substances to counteract QS, such as enzymes, synthetic inhibitors, natural plant extracts, and antimicrobial peptides, is a viable tactic. We covered new research on QS mechanisms in DFUs, clinical results associated with QS activity, and developing anti-QS treatments in this review, emphasizing translational challenges and prospects for the future.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Diabetic foot infections are a prevalent side effect of the disease and a concerning public health concern that can have major repercussions, including amputations and even diabetic deaths. Minor foot injuries have a significant chance of developing into potentially fatal infections due to opportunistic microorganisms from the patient’s surroundings. Polymicrobial biofilms commonly found in diabetic foot ulcers (DFUs) use quorum sensing (QS) to coordinate antibiotic tolerance, persistence, and virulence. QS-mediated co-ordination facilitates the formation of extracellular polymeric substance, the expression of proteases and poisons, immunological evasion, and persister cell survival. Clinically, these characteristics increase the likelihood of hospitalization and amputation, stimulate persistent infection, and hinder wound healing. Using inhibitory substances to counteract QS, such as enzymes, synthetic inhibitors, natural plant extracts, and antimicrobial peptides, is a viable tactic. We covered new research on QS mechanisms in DFUs, clinical results associated with QS activity, and developing anti-QS treatments in this review, emphasizing translational challenges and prospects for the future.
Pathan, Habib Khan Gulab Khan; Sarmast, Syed Shah Naseeruddin; Reddy, M. Pavan; Qurram, Syed Mohammad Nusrath
Early detection of autism in childhood outpatient department practice: insight from pediatric neurology in Hyderabad, India Journal Article
In: International Journal of Contemporary Pediatrics, vol. 13, iss. 2, pp. 261-267, 2026, ISSN: 2349-3283.
@article{Pathan_2026,
title = {Early detection of autism in childhood outpatient department practice: insight from pediatric neurology in Hyderabad, India},
author = {Habib Khan Gulab Khan Pathan and Syed Shah Naseeruddin Sarmast and M. Pavan Reddy and Syed Mohammad Nusrath Qurram},
url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/7152/4347},
doi = {10.18203/2349-3291.ijcp20260098 },
issn = {2349-3283},
year = {2026},
date = {2026-01-27},
urldate = {2026-01-27},
journal = {International Journal of Contemporary Pediatrics},
volume = {13},
issue = {2},
pages = {261-267},
abstract = {Background: Autism spectrum disorder (ASD) is prevalent neurodevelopmental disorder marked by core challenges in social communication, social interaction and presence of restrictive and repetitive behaviors. Early identification through effective screening is essential, as timely intervention significantly enhances developmental outcomes.
Methods: This descriptive cross-sectional study was conducted on a sample of 506 children aged 16 to 30 months attending the pediatric OPD clinic. Eligible children who met the inclusion criteria were screened for the risk of autism using the revised modified checklist for autism in toddlers (Revised M-CHAT).
Results: Among 506 children screened with the revised M-CHAT tool, 1.6% screened positive for ASD. The study population had a mean age of approximately 21.6 months without male predominance (59.6%). Key factors significantly associated with positive ASD screening included partial immunization, preterm birth, lack of exclusive breastfeeding, and exposure to more than 2 hours of screen time. Other demographic variables such as gender, mode of delivery, and parental education showed no significant association. Revised M-CHAT questionnaire items (notably questions 1, 2, 7, 10, and 12) were frequently positive among ASD screen-positive children, suggesting particular sensitivity for screening. Breastfeeding, screen-time exposure and immunization are confirmed statistically by this study.
Conclusions: All toddlers attending Pediatric clinics should be routinely screened for autism by a child specialist. The revised M-CHAT is a simple, easy-to-administer, and validated screening tool suitable for use in busy pediatric outpatient settings.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Autism spectrum disorder (ASD) is prevalent neurodevelopmental disorder marked by core challenges in social communication, social interaction and presence of restrictive and repetitive behaviors. Early identification through effective screening is essential, as timely intervention significantly enhances developmental outcomes.
Methods: This descriptive cross-sectional study was conducted on a sample of 506 children aged 16 to 30 months attending the pediatric OPD clinic. Eligible children who met the inclusion criteria were screened for the risk of autism using the revised modified checklist for autism in toddlers (Revised M-CHAT).
Results: Among 506 children screened with the revised M-CHAT tool, 1.6% screened positive for ASD. The study population had a mean age of approximately 21.6 months without male predominance (59.6%). Key factors significantly associated with positive ASD screening included partial immunization, preterm birth, lack of exclusive breastfeeding, and exposure to more than 2 hours of screen time. Other demographic variables such as gender, mode of delivery, and parental education showed no significant association. Revised M-CHAT questionnaire items (notably questions 1, 2, 7, 10, and 12) were frequently positive among ASD screen-positive children, suggesting particular sensitivity for screening. Breastfeeding, screen-time exposure and immunization are confirmed statistically by this study.
Conclusions: All toddlers attending Pediatric clinics should be routinely screened for autism by a child specialist. The revised M-CHAT is a simple, easy-to-administer, and validated screening tool suitable for use in busy pediatric outpatient settings.
Methods: This descriptive cross-sectional study was conducted on a sample of 506 children aged 16 to 30 months attending the pediatric OPD clinic. Eligible children who met the inclusion criteria were screened for the risk of autism using the revised modified checklist for autism in toddlers (Revised M-CHAT).
Results: Among 506 children screened with the revised M-CHAT tool, 1.6% screened positive for ASD. The study population had a mean age of approximately 21.6 months without male predominance (59.6%). Key factors significantly associated with positive ASD screening included partial immunization, preterm birth, lack of exclusive breastfeeding, and exposure to more than 2 hours of screen time. Other demographic variables such as gender, mode of delivery, and parental education showed no significant association. Revised M-CHAT questionnaire items (notably questions 1, 2, 7, 10, and 12) were frequently positive among ASD screen-positive children, suggesting particular sensitivity for screening. Breastfeeding, screen-time exposure and immunization are confirmed statistically by this study.
Conclusions: All toddlers attending Pediatric clinics should be routinely screened for autism by a child specialist. The revised M-CHAT is a simple, easy-to-administer, and validated screening tool suitable for use in busy pediatric outpatient settings.
Begum, Nadira; Shaik, Noor Mariam; Tazeen, Naushaba; Afroze, Idrees Akhtar
Beyond the break: breast carcinoma unveiled – an unusual case report Journal Article
In: MRIMS Journal of Health Sciences, 2026, (Published online ahead-of-print).
@article{Begum_2026,
title = {Beyond the break: breast carcinoma unveiled – an unusual case report},
author = {Nadira Begum and Noor Mariam Shaik and Naushaba Tazeen and Idrees Akhtar Afroze},
url = {https://journals.lww.com/mjhs/abstract/9900/beyond_the_break__breast_carcinoma_unveiled___an.104.aspx},
doi = {10.4103/mjhs.mjhs_77_25},
year = {2026},
date = {2026-01-21},
urldate = {2026-01-21},
journal = {MRIMS Journal of Health Sciences},
abstract = {Unusual initial presentations of common malignancies can lead to delayed diagnosis and treatment. We report the case of a 49-year-old woman who presented with fractures of the left femur and right humerus following a minor fall. Unexpectedly, pathological examination of the bone tissue revealed metastatic carcinoma. Imaging studies subsequently identified a primary lesion in the right breast with widespread skeletal involvement. Only 0.4%–1% of breast cancer patients initially present with symptoms of bone metastasis. This case emphasises the crucial role of vigilance and pathological assessment in uncovering hidden primary malignancies. It also highlights the need to consider underlying carcinoma as a differential diagnosis even in routine orthopaedic cases of low-impact fractures.},
note = {Published online ahead-of-print},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Unusual initial presentations of common malignancies can lead to delayed diagnosis and treatment. We report the case of a 49-year-old woman who presented with fractures of the left femur and right humerus following a minor fall. Unexpectedly, pathological examination of the bone tissue revealed metastatic carcinoma. Imaging studies subsequently identified a primary lesion in the right breast with widespread skeletal involvement. Only 0.4%–1% of breast cancer patients initially present with symptoms of bone metastasis. This case emphasises the crucial role of vigilance and pathological assessment in uncovering hidden primary malignancies. It also highlights the need to consider underlying carcinoma as a differential diagnosis even in routine orthopaedic cases of low-impact fractures.
Bogam, Rahul R.; Chavan, Vishwajeet M.; AlMbaidin, Lina R.; Krishna, Madhipati Sai
Digital intervention to promote lifestyle changes among pre-diabetic and obese adults – a study from rural area of Pune, India Journal Article
In: Preventive Medicine Research & Reviews, 2026, ISSN: 2950-5828, (Published online ahead-of-print).
@article{Bogam_2026,
title = {Digital intervention to promote lifestyle changes among pre-diabetic and obese adults – a study from rural area of Pune, India},
author = {Rahul R. Bogam and Vishwajeet M. Chavan and Lina R. AlMbaidin and Madhipati Sai Krishna},
url = {https://journals.lww.com/pmrr/fulltext/9900/digital_intervention_to_promote_lifestyle_changes.145.aspx},
doi = {10.4103/PMRR.PMRR_252_25},
issn = {2950-5828},
year = {2026},
date = {2026-01-20},
urldate = {2026-01-20},
journal = {Preventive Medicine Research & Reviews},
abstract = {Introduction: Pre-diabetes and obesity signify rising public health challenges in India, contributing to the escalating burden of type 2 diabetes and its complications. While lifestyle interventions are effective, traditional face-to-face programmes face hurdles of cost, access and scalability. This study explored the feasibility and effect of a 6-month digital lifestyle intervention delivered via mobile technology in rural Indian setting.
Methods: An educational interventional study was conducted among 40 overweight/obese and pre-diabetes adults at designated rural health center in Pune City. The study group (n = 20) received a 6-month, app-based intervention while the control group (n = 20) was sensitised with traditional lectures for 6 months. Knowledge, anthropometric, glycemic and behavioral outcomes were measured at baseline and 6 months. The differences between intervention and control groups were compared using appropriate statistical methods.
Results: The study group showed greater improvement in knowledge, weight and glycemic outcomes compared with controls.
Conclusions: A 6-month digital lifestyle programme was feasible, well-received and associated with improvements in weight, glycemic control and diabetes-related knowledge among pre-diabetic, obese adults.},
note = {Published online ahead-of-print},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Pre-diabetes and obesity signify rising public health challenges in India, contributing to the escalating burden of type 2 diabetes and its complications. While lifestyle interventions are effective, traditional face-to-face programmes face hurdles of cost, access and scalability. This study explored the feasibility and effect of a 6-month digital lifestyle intervention delivered via mobile technology in rural Indian setting.
Methods: An educational interventional study was conducted among 40 overweight/obese and pre-diabetes adults at designated rural health center in Pune City. The study group (n = 20) received a 6-month, app-based intervention while the control group (n = 20) was sensitised with traditional lectures for 6 months. Knowledge, anthropometric, glycemic and behavioral outcomes were measured at baseline and 6 months. The differences between intervention and control groups were compared using appropriate statistical methods.
Results: The study group showed greater improvement in knowledge, weight and glycemic outcomes compared with controls.
Conclusions: A 6-month digital lifestyle programme was feasible, well-received and associated with improvements in weight, glycemic control and diabetes-related knowledge among pre-diabetic, obese adults.
Methods: An educational interventional study was conducted among 40 overweight/obese and pre-diabetes adults at designated rural health center in Pune City. The study group (n = 20) received a 6-month, app-based intervention while the control group (n = 20) was sensitised with traditional lectures for 6 months. Knowledge, anthropometric, glycemic and behavioral outcomes were measured at baseline and 6 months. The differences between intervention and control groups were compared using appropriate statistical methods.
Results: The study group showed greater improvement in knowledge, weight and glycemic outcomes compared with controls.
Conclusions: A 6-month digital lifestyle programme was feasible, well-received and associated with improvements in weight, glycemic control and diabetes-related knowledge among pre-diabetic, obese adults.
Bushra,; Begum, Safia; Ahmed, Shaik Iqbal; Pasha, Akbar; Kande, Ramesh; Khan, Mohammed Affan Osman; Khan, Aleem Ahmed
In: European Journal of Trauma and Emergency Surgery , vol. 52, iss. 1, no. pmid41528462, 2026, ISSN: 1863-9933.
@article{Bushra_2026,
title = {Assessment of circulating cell-free mitochondrial DNA as a damage associated molecular pattern in predicting severity and mortality of sepsis and septic shock patients},
author = {Bushra and Safia Begum and Shaik Iqbal Ahmed and Akbar Pasha and Ramesh Kande and Mohammed Affan Osman Khan and Aleem Ahmed Khan},
url = {https://pubmed.ncbi.nlm.nih.gov/41528462/},
doi = {10.1007/s00068-025-03058-4},
issn = {1863-9933},
year = {2026},
date = {2026-01-13},
urldate = {2026-01-13},
journal = {European Journal of Trauma and Emergency Surgery },
volume = {52},
number = {pmid41528462},
issue = {1},
abstract = {Background: Sepsis and septic shock are life-threatening conditions with high mortality, presenting challenges in predicting disease severity and outcomes. Cell-free mitochondrial DNA (mtDNA) has emerged as a potential mediator in sepsis pathogenesis, acting as a damage-associated molecular pattern (DAMP) that exacerbates inflammation. The present study aimed to assess cell-free mtDNA levels as predictors of mortality and disease severity, and to determine their correlation with established clinical markers.
Methods: A prospective study enrolled 150 participants, including healthy controls (n = 50) and patients (n = 100, of which 50 had sepsis and 50 had septic shock). Plasma cell-free mtDNA levels were quantified using RT-qPCR, and Receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of cell-free mtDNA for 28-day mortality. The cell-free mtDNA correlated with clinical markers, including C-reactive protein (CRP), Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation (APACHE II), Procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR), and lactate.
Results: Cell-free mtDNA levels were significantly elevated in sepsis and septic shock patients compared to controls, and higher in septic shock compared to sepsis patients. Non-survivors exhibited significantly higher cell-free mtDNA levels than survivors across both sepsis and septic shock subgroups. Cell-free mtDNA demonstrated a superior predictive value for 28-day mortality, area under the curve (AUC = 0.865) compared to clinical markers (CRP, SOFA, PCT, NLR, and Lactate). Furthermore, cell-free mtDNA levels showed a positive correlation with CRP, followed by SOFA, NLR, and PCT.
Conclusion: Elevated circulating cell-free mtDNA levels were associated with severity and mortality in sepsis and septic shock, and may act as a valuable molecular tool for predicting disease outcomes. The study's findings warrant further investigation into the potential of cell-free mtDNA as a future component of clinical management strategies in sepsis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Sepsis and septic shock are life-threatening conditions with high mortality, presenting challenges in predicting disease severity and outcomes. Cell-free mitochondrial DNA (mtDNA) has emerged as a potential mediator in sepsis pathogenesis, acting as a damage-associated molecular pattern (DAMP) that exacerbates inflammation. The present study aimed to assess cell-free mtDNA levels as predictors of mortality and disease severity, and to determine their correlation with established clinical markers.
Methods: A prospective study enrolled 150 participants, including healthy controls (n = 50) and patients (n = 100, of which 50 had sepsis and 50 had septic shock). Plasma cell-free mtDNA levels were quantified using RT-qPCR, and Receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of cell-free mtDNA for 28-day mortality. The cell-free mtDNA correlated with clinical markers, including C-reactive protein (CRP), Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation (APACHE II), Procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR), and lactate.
Results: Cell-free mtDNA levels were significantly elevated in sepsis and septic shock patients compared to controls, and higher in septic shock compared to sepsis patients. Non-survivors exhibited significantly higher cell-free mtDNA levels than survivors across both sepsis and septic shock subgroups. Cell-free mtDNA demonstrated a superior predictive value for 28-day mortality, area under the curve (AUC = 0.865) compared to clinical markers (CRP, SOFA, PCT, NLR, and Lactate). Furthermore, cell-free mtDNA levels showed a positive correlation with CRP, followed by SOFA, NLR, and PCT.
Conclusion: Elevated circulating cell-free mtDNA levels were associated with severity and mortality in sepsis and septic shock, and may act as a valuable molecular tool for predicting disease outcomes. The study's findings warrant further investigation into the potential of cell-free mtDNA as a future component of clinical management strategies in sepsis.
Methods: A prospective study enrolled 150 participants, including healthy controls (n = 50) and patients (n = 100, of which 50 had sepsis and 50 had septic shock). Plasma cell-free mtDNA levels were quantified using RT-qPCR, and Receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of cell-free mtDNA for 28-day mortality. The cell-free mtDNA correlated with clinical markers, including C-reactive protein (CRP), Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation (APACHE II), Procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR), and lactate.
Results: Cell-free mtDNA levels were significantly elevated in sepsis and septic shock patients compared to controls, and higher in septic shock compared to sepsis patients. Non-survivors exhibited significantly higher cell-free mtDNA levels than survivors across both sepsis and septic shock subgroups. Cell-free mtDNA demonstrated a superior predictive value for 28-day mortality, area under the curve (AUC = 0.865) compared to clinical markers (CRP, SOFA, PCT, NLR, and Lactate). Furthermore, cell-free mtDNA levels showed a positive correlation with CRP, followed by SOFA, NLR, and PCT.
Conclusion: Elevated circulating cell-free mtDNA levels were associated with severity and mortality in sepsis and septic shock, and may act as a valuable molecular tool for predicting disease outcomes. The study's findings warrant further investigation into the potential of cell-free mtDNA as a future component of clinical management strategies in sepsis.
2025
Bharathi, S.; Shaikh, Ridah; Khan, Mohd. Ahmedulla
Etiological profile of fever of short duration without focus in children aged 1–36 months: a tertiary care hospital-based study Journal Article
In: American journal of Psychiatric Rehabilitation, vol. 28, iss. 5, pp. 1969-1973, 2025, ISSN: 1548-7776.
@article{Bharathi_2025,
title = {Etiological profile of fever of short duration without focus in children aged 1–36 months: a tertiary care hospital-based study},
author = {S. Bharathi and Ridah Shaikh and Mohd. Ahmedulla Khan},
url = {https://ajprui.com/index.php/ajpr/article/view/830/616},
doi = {10.69980/ajpr.v28i5.830 },
issn = {1548-7776},
year = {2025},
date = {2025-12-15},
urldate = {2025-12-15},
journal = {American journal of Psychiatric Rehabilitation},
volume = {28},
issue = {5},
pages = {1969-1973},
abstract = {Background: Fever without focus (FWS) in children aged 1–36 months presents a significant diagnostic challenge to pediatricians. Although most cases are due to self-limiting viral infections, a subset represents serious bacterial infections (SBI), including urinary tract infections (UTI), bacteremia, pneumonia, meningitis, and enteric fever. Early identification is essential to prevent morbidity and mortality while avoiding unnecessary hospitalization and antibiotic exposure.
Objectives: To determine the etiological profile of fever of short duration (<7 days) without localizing signs in children aged 1–36 months and to identify common organisms causing septicemia and urinary infections.
Methods: This prospective observational study was conducted in a tertiary care hospital. Children aged 1–36 months presenting with fever ≥38°C without identifiable focus on clinical examination were enrolled. Detailed clinical evaluation and laboratory investigations including complete blood count, blood culture, urine analysis and culture, chest radiography, cerebrospinal fluid analysis (when indicated), and serological tests were performed.
Results: The majority of cases were viral or self-limiting illnesses. Among serious bacterial infections, urinary tract infection was the most common cause, followed by bacteremia and pneumonia. Escherichia coli was the predominant organism in urine cultures, while Streptococcus pneumoniae and Staphylococcus aureus were common isolates in blood cultures. Younger infants had a higher incidence of serious bacterial infection.
Conclusion: While most cases of fever without focus are benign, urinary tract infection remains the most frequent serious bacterial infection in children 1–36 months. Rational use of investigations and close follow-up are crucial to balance early diagnosis and antimicrobial stewardship.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Fever without focus (FWS) in children aged 1–36 months presents a significant diagnostic challenge to pediatricians. Although most cases are due to self-limiting viral infections, a subset represents serious bacterial infections (SBI), including urinary tract infections (UTI), bacteremia, pneumonia, meningitis, and enteric fever. Early identification is essential to prevent morbidity and mortality while avoiding unnecessary hospitalization and antibiotic exposure.
Objectives: To determine the etiological profile of fever of short duration (<7 days) without localizing signs in children aged 1–36 months and to identify common organisms causing septicemia and urinary infections.
Methods: This prospective observational study was conducted in a tertiary care hospital. Children aged 1–36 months presenting with fever ≥38°C without identifiable focus on clinical examination were enrolled. Detailed clinical evaluation and laboratory investigations including complete blood count, blood culture, urine analysis and culture, chest radiography, cerebrospinal fluid analysis (when indicated), and serological tests were performed.
Results: The majority of cases were viral or self-limiting illnesses. Among serious bacterial infections, urinary tract infection was the most common cause, followed by bacteremia and pneumonia. Escherichia coli was the predominant organism in urine cultures, while Streptococcus pneumoniae and Staphylococcus aureus were common isolates in blood cultures. Younger infants had a higher incidence of serious bacterial infection.
Conclusion: While most cases of fever without focus are benign, urinary tract infection remains the most frequent serious bacterial infection in children 1–36 months. Rational use of investigations and close follow-up are crucial to balance early diagnosis and antimicrobial stewardship.
Objectives: To determine the etiological profile of fever of short duration (<7 days) without localizing signs in children aged 1–36 months and to identify common organisms causing septicemia and urinary infections.
Methods: This prospective observational study was conducted in a tertiary care hospital. Children aged 1–36 months presenting with fever ≥38°C without identifiable focus on clinical examination were enrolled. Detailed clinical evaluation and laboratory investigations including complete blood count, blood culture, urine analysis and culture, chest radiography, cerebrospinal fluid analysis (when indicated), and serological tests were performed.
Results: The majority of cases were viral or self-limiting illnesses. Among serious bacterial infections, urinary tract infection was the most common cause, followed by bacteremia and pneumonia. Escherichia coli was the predominant organism in urine cultures, while Streptococcus pneumoniae and Staphylococcus aureus were common isolates in blood cultures. Younger infants had a higher incidence of serious bacterial infection.
Conclusion: While most cases of fever without focus are benign, urinary tract infection remains the most frequent serious bacterial infection in children 1–36 months. Rational use of investigations and close follow-up are crucial to balance early diagnosis and antimicrobial stewardship.
Khan, Nayab Arshad Ali; Bharathi, S.
A cross sectional case control study on role of iron deficiency anemia in febrile seizures Journal Article
In: Journal of Population Therapeutics & Clinical Pharmacology, vol. 32, iss. 11, pp. 2223-2228, 2025, ISSN: 1710-6222.
@article{Khan_2025,
title = {A cross sectional case control study on role of iron deficiency anemia in febrile seizures},
author = {Nayab Arshad Ali Khan and S. Bharathi},
url = {https://jptcp.com/index.php/jptcp/article/view/13224/12293},
doi = {10.53555/gbyvrs04 },
issn = {1710-6222},
year = {2025},
date = {2025-12-15},
urldate = {2025-12-15},
journal = {Journal of Population Therapeutics & Clinical Pharmacology},
volume = {32},
issue = {11},
pages = {2223-2228},
abstract = {Background: Febrile seizures (FS) are the most common convulsive disorder in children aged 6–60 months. Iron deficiency anaemia (IDA) has been proposed as a potential risk factor, yet the precise relationship remains debated. This study aimed to evaluate the role of IDA in FS by comparing haematological parameters between children with and without febrile seizures.
Methods: A hospital-based cross-sectional comparative study was conducted on 100 children (6–60 months). Group I (n=50) comprised children with febrile seizures and Group II (n=50) comprised febrile children without seizures. Haematological parameters — Haemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), and Serum Ferritin — were compared between the two groups. Chi-square test and Pearson's correlation were used for statistical analysis.
Results: Anaemia (Hb <11 g/dL) was present in 76% of Group I vs. 44% of Group II (p=0.001, OR=3.97). Low MCV (<70 fL) was found in 64% vs. 38% (p=0.009, OR=2.86). Low MCH (<27 pg) was present in 84% vs. 64% (p=0.02, OR=2.92). Serum ferritin <30 ng/mL was found in 68% vs. 24% (p=0.00001, OR=6.58). No statistically significant association was found between IDA parameters and seizure recurrence.
Conclusion: Iron deficiency anaemia is a significant and potentially modifiable risk factor for febrile seizures in children. Early detection and timely correction of IDA may help prevent febrile seizures in this age group. Routine screening for IDA is recommended in all children presenting with febrile seizures.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Febrile seizures (FS) are the most common convulsive disorder in children aged 6–60 months. Iron deficiency anaemia (IDA) has been proposed as a potential risk factor, yet the precise relationship remains debated. This study aimed to evaluate the role of IDA in FS by comparing haematological parameters between children with and without febrile seizures.
Methods: A hospital-based cross-sectional comparative study was conducted on 100 children (6–60 months). Group I (n=50) comprised children with febrile seizures and Group II (n=50) comprised febrile children without seizures. Haematological parameters — Haemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), and Serum Ferritin — were compared between the two groups. Chi-square test and Pearson's correlation were used for statistical analysis.
Results: Anaemia (Hb <11 g/dL) was present in 76% of Group I vs. 44% of Group II (p=0.001, OR=3.97). Low MCV (<70 fL) was found in 64% vs. 38% (p=0.009, OR=2.86). Low MCH (<27 pg) was present in 84% vs. 64% (p=0.02, OR=2.92). Serum ferritin <30 ng/mL was found in 68% vs. 24% (p=0.00001, OR=6.58). No statistically significant association was found between IDA parameters and seizure recurrence.
Conclusion: Iron deficiency anaemia is a significant and potentially modifiable risk factor for febrile seizures in children. Early detection and timely correction of IDA may help prevent febrile seizures in this age group. Routine screening for IDA is recommended in all children presenting with febrile seizures.
Methods: A hospital-based cross-sectional comparative study was conducted on 100 children (6–60 months). Group I (n=50) comprised children with febrile seizures and Group II (n=50) comprised febrile children without seizures. Haematological parameters — Haemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), and Serum Ferritin — were compared between the two groups. Chi-square test and Pearson's correlation were used for statistical analysis.
Results: Anaemia (Hb <11 g/dL) was present in 76% of Group I vs. 44% of Group II (p=0.001, OR=3.97). Low MCV (<70 fL) was found in 64% vs. 38% (p=0.009, OR=2.86). Low MCH (<27 pg) was present in 84% vs. 64% (p=0.02, OR=2.92). Serum ferritin <30 ng/mL was found in 68% vs. 24% (p=0.00001, OR=6.58). No statistically significant association was found between IDA parameters and seizure recurrence.
Conclusion: Iron deficiency anaemia is a significant and potentially modifiable risk factor for febrile seizures in children. Early detection and timely correction of IDA may help prevent febrile seizures in this age group. Routine screening for IDA is recommended in all children presenting with febrile seizures.
ul Haq, Mohammed Zia; Kadloor, Parvaiz; Bangi, Sayed Mohammed Hussain
A study of clinical profile, chest X-ray, ECG changes, and 2D echocardiography in patients with chronic cor pulmonale Journal Article
In: International Journal of the Cardiovascular Academy, vol. 11, iss. 4, pp. 179-184, 2025, ISSN: 2405-819X.
@article{Haq_2025,
title = {A study of clinical profile, chest X-ray, ECG changes, and 2D echocardiography in patients with chronic cor pulmonale},
author = {Mohammed Zia ul Haq and Parvaiz Kadloor and Sayed Mohammed Hussain Bangi},
url = {https://ijcva.org/pdf/1fe4afca-adad-4137-be7c-36a5e5ab6910/articles/ijca.2025.73745/179-184.pdf},
doi = {10.4274/ijca.2025.73745},
issn = {2405-819X},
year = {2025},
date = {2025-12-12},
urldate = {2025-12-12},
journal = {International Journal of the Cardiovascular Academy},
volume = {11},
issue = {4},
pages = {179-184},
abstract = {Background and Aim: Chronic obstructive pulmonary disease may result in chronic cor pulmonale, which is defined as right ventricular dilatation and/or hypertrophy resulting from pulmonary hypertension. A non-spesific clinical presentation and limited access to advanced diagnostic tools in resource-constrained settings make early diagnosis challenging. To evaluate the clinical profile and diagnostic findings from chest radiography, electrocardiography (ECG), and two-dimensional echocardiography in patients with clinically confirmed chronic cor pulmonale.
Materials and Methods: A retrospective observational study was conducted at a tertiary care center from October 2016 to September 2018. A total of 50 patients aged 30 to 80 years with clinically diagnosed chronic cor pulmonale were enrolled. Clinical symptoms, radiographic changes, ECG findings, pulmonary function tests (PFTs), and echocardiographic parameters were studied.
Results: The mean age of patients in our study was 51.7 years, with a male predominance (92%). The most common presenting features included breathlessness (100%), productive cough (100%), swelling of the feet (86%), and loss of appetite (92%). Chronic bronchitis with emphysema was the most frequent etiology, accounting for 58% of cases. Chest X-rays revealed chronic bronchitis with emphysema in 58% of patients, increased transverse cardiac diameter in 40% of patients, and a right descending pulmonary artery diameter greater than 16 mm in 62% of patients. ECG findings included right axis deviation (86%), P pulmonale (74%), low-voltage QRS complexes (52%), and arrhythmias (72%). Obstructive patterns were observed in 96% of PFTs. Echocardiography demonstrated dilation of the right ventricle and right atrium in all patients, right ventricular hypertrophy in 84% of patients, pulmonary hypertension in 90% of patients, and tricuspid regurgitation in 90% of patients. Moderate-to-severe pulmonary hypertension was observed in 74% of patients.
Conclusion: In the present study, chronic bronchitis with emphysema was the predominant cause of chronic cor pulmonale among middle-aged males. Multimodal assessment using clinical, radiographic, ECG, and echocardiographic findings enables early diagnosis. Echocardiography serves as a critical tool for evaluating right heart involvement and guiding timely intervention in chronic cor pulmonale.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background and Aim: Chronic obstructive pulmonary disease may result in chronic cor pulmonale, which is defined as right ventricular dilatation and/or hypertrophy resulting from pulmonary hypertension. A non-spesific clinical presentation and limited access to advanced diagnostic tools in resource-constrained settings make early diagnosis challenging. To evaluate the clinical profile and diagnostic findings from chest radiography, electrocardiography (ECG), and two-dimensional echocardiography in patients with clinically confirmed chronic cor pulmonale.
Materials and Methods: A retrospective observational study was conducted at a tertiary care center from October 2016 to September 2018. A total of 50 patients aged 30 to 80 years with clinically diagnosed chronic cor pulmonale were enrolled. Clinical symptoms, radiographic changes, ECG findings, pulmonary function tests (PFTs), and echocardiographic parameters were studied.
Results: The mean age of patients in our study was 51.7 years, with a male predominance (92%). The most common presenting features included breathlessness (100%), productive cough (100%), swelling of the feet (86%), and loss of appetite (92%). Chronic bronchitis with emphysema was the most frequent etiology, accounting for 58% of cases. Chest X-rays revealed chronic bronchitis with emphysema in 58% of patients, increased transverse cardiac diameter in 40% of patients, and a right descending pulmonary artery diameter greater than 16 mm in 62% of patients. ECG findings included right axis deviation (86%), P pulmonale (74%), low-voltage QRS complexes (52%), and arrhythmias (72%). Obstructive patterns were observed in 96% of PFTs. Echocardiography demonstrated dilation of the right ventricle and right atrium in all patients, right ventricular hypertrophy in 84% of patients, pulmonary hypertension in 90% of patients, and tricuspid regurgitation in 90% of patients. Moderate-to-severe pulmonary hypertension was observed in 74% of patients.
Conclusion: In the present study, chronic bronchitis with emphysema was the predominant cause of chronic cor pulmonale among middle-aged males. Multimodal assessment using clinical, radiographic, ECG, and echocardiographic findings enables early diagnosis. Echocardiography serves as a critical tool for evaluating right heart involvement and guiding timely intervention in chronic cor pulmonale.
Materials and Methods: A retrospective observational study was conducted at a tertiary care center from October 2016 to September 2018. A total of 50 patients aged 30 to 80 years with clinically diagnosed chronic cor pulmonale were enrolled. Clinical symptoms, radiographic changes, ECG findings, pulmonary function tests (PFTs), and echocardiographic parameters were studied.
Results: The mean age of patients in our study was 51.7 years, with a male predominance (92%). The most common presenting features included breathlessness (100%), productive cough (100%), swelling of the feet (86%), and loss of appetite (92%). Chronic bronchitis with emphysema was the most frequent etiology, accounting for 58% of cases. Chest X-rays revealed chronic bronchitis with emphysema in 58% of patients, increased transverse cardiac diameter in 40% of patients, and a right descending pulmonary artery diameter greater than 16 mm in 62% of patients. ECG findings included right axis deviation (86%), P pulmonale (74%), low-voltage QRS complexes (52%), and arrhythmias (72%). Obstructive patterns were observed in 96% of PFTs. Echocardiography demonstrated dilation of the right ventricle and right atrium in all patients, right ventricular hypertrophy in 84% of patients, pulmonary hypertension in 90% of patients, and tricuspid regurgitation in 90% of patients. Moderate-to-severe pulmonary hypertension was observed in 74% of patients.
Conclusion: In the present study, chronic bronchitis with emphysema was the predominant cause of chronic cor pulmonale among middle-aged males. Multimodal assessment using clinical, radiographic, ECG, and echocardiographic findings enables early diagnosis. Echocardiography serves as a critical tool for evaluating right heart involvement and guiding timely intervention in chronic cor pulmonale.
Fatima, Arshiya; Syed, Zaid Mazhar; Husayni, Syed Mohammed Sajjad
Evaluation of emergency laparotomy for ileocaecal emergencies a clinicopathology, prognosis, and outcome based study Journal Article
In: Journal of Contemporary Clinical Practice, vol. 11, iss. 11, pp. 1034-1039, 2025, ISSN: 2457-7200.
@article{Fatima_2025h,
title = {Evaluation of emergency laparotomy for ileocaecal emergencies a clinicopathology, prognosis, and outcome based study},
author = {Arshiya Fatima and Zaid Mazhar Syed and Syed Mohammed Sajjad Husayni},
url = {https://jccpractice.com/article/evaluation-of-emergency-laparotomy-for-ileocaecal-emergencies-a-clinicopathology-prognosis-and-outcome-based-study-1712/},
doi = {10.61336/jccp/25-11-129},
issn = {2457-7200},
year = {2025},
date = {2025-12-11},
urldate = {2025-12-11},
journal = {Journal of Contemporary Clinical Practice},
volume = {11},
issue = {11},
pages = {1034-1039},
abstract = {Background and Objectives: Ileocaecal emergencies, such as perforation, blockage, and inflammatory or viral diseases, continue to be prevalent causes of acute abdomen necessitating immediate laparotomy. These disorders are linked to considerable morbidity and mortality, particularly when diagnosis or management is postponed. The current study sought to assess the clinicopathological characteristics, surgical findings, postoperative complications, prognosis, and overall outcomes of patients receiving emergency laparotomy for ileocecal crises. Materials and Methods: Most of the 60 patients were men, and the age group with the most cases was 30 to 50 years old. 95% of the symptoms were stomach pain, followed by vomiting (72%) and stomach distension (60%). The most common causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal blockage (20%), and tuberculosis-related pathology (15%). Loop ileostomy, resection with anastomosis, and primary closure were some of the most common methods used. 35% of patients had complications after surgery, with infections at the surgery site being the most prevalent. Results: Among the 60 patients, the majority were males, with the highest incidence in the 30–50-year age group. The most common presenting symptoms were abdominal pain (95%), vomiting (72%), and abdominal distension (60%). The leading causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal obstruction (20%), and tuberculosis-related pathology (15%). Primary closure, resection with anastomosis, and loop ileostomy were the commonly performed procedures. Postoperative complications occurred in 35% of patients, with surgical site infection being the most frequent. The overall mortality rate was 10%, primarily associated with delayed presentation, septic shock, and extensive peritoneal contamination. Early surgical intervention significantly improved outcomes. Conclusion: Ileocaecal emergencies remain significant clinical issues necessitating rapid diagnosis and quick surgical intervention to mitigate morbidity and mortality. Early presentation, vigorous resuscitation, and suitable surgical interventions are crucial factors influencing positive outcomes. Improving perioperative care and making early referral systems stronger can make patients' chances of getting better even better.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background and Objectives: Ileocaecal emergencies, such as perforation, blockage, and inflammatory or viral diseases, continue to be prevalent causes of acute abdomen necessitating immediate laparotomy. These disorders are linked to considerable morbidity and mortality, particularly when diagnosis or management is postponed. The current study sought to assess the clinicopathological characteristics, surgical findings, postoperative complications, prognosis, and overall outcomes of patients receiving emergency laparotomy for ileocecal crises. Materials and Methods: Most of the 60 patients were men, and the age group with the most cases was 30 to 50 years old. 95% of the symptoms were stomach pain, followed by vomiting (72%) and stomach distension (60%). The most common causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal blockage (20%), and tuberculosis-related pathology (15%). Loop ileostomy, resection with anastomosis, and primary closure were some of the most common methods used. 35% of patients had complications after surgery, with infections at the surgery site being the most prevalent. Results: Among the 60 patients, the majority were males, with the highest incidence in the 30–50-year age group. The most common presenting symptoms were abdominal pain (95%), vomiting (72%), and abdominal distension (60%). The leading causes of ileocaecal emergencies were ileal perforation (40%), typhoid perforation (25%), intestinal obstruction (20%), and tuberculosis-related pathology (15%). Primary closure, resection with anastomosis, and loop ileostomy were the commonly performed procedures. Postoperative complications occurred in 35% of patients, with surgical site infection being the most frequent. The overall mortality rate was 10%, primarily associated with delayed presentation, septic shock, and extensive peritoneal contamination. Early surgical intervention significantly improved outcomes. Conclusion: Ileocaecal emergencies remain significant clinical issues necessitating rapid diagnosis and quick surgical intervention to mitigate morbidity and mortality. Early presentation, vigorous resuscitation, and suitable surgical interventions are crucial factors influencing positive outcomes. Improving perioperative care and making early referral systems stronger can make patients' chances of getting better even better.
Books Published
2025
Manorenj, Sandhya
Seizure Semiology in Clinical Practice: From symptom analysis to localization Book
Kindle, Amazon KDP, 2025, ISBN: 9798241833440.
@book{Manorenj_2025j,
title = {Seizure Semiology in Clinical Practice: From symptom analysis to localization},
author = {Sandhya Manorenj},
url = {https://www.amazon.in/Seizure-Semiology-Clinical-Practice-Localization-ebook/dp/B0GDHS7TFY},
isbn = {9798241833440},
year = {2025},
date = {2025-12-31},
number = { ASIN: B0GDHS7TFY },
publisher = {Amazon KDP},
edition = {Kindle},
abstract = {Seizure Semiology in Clinical Practice is designed as a practical and clinically oriented guide to understanding seizure manifestations and their localizing and lateralizing value. The book serves as a valuable resource for neurology residents, general medicine residents, epilepsy fellows, budding neurologists, epileptologists, and neurotechnologists by translating bedside observations into meaningful diagnostic insights. Emphasis is placed on real-world application, helping readers correlate seizure behaviors with underlying neuroanatomy and an approach to history taking. By strengthening clinical acumen and improving seizure recognition, this book ultimately supports accurate diagnosis, timely referral, and optimal management, thereby enhancing the quality of care delivered to patients with epilepsy and related seizure disorders.},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Seizure Semiology in Clinical Practice is designed as a practical and clinically oriented guide to understanding seizure manifestations and their localizing and lateralizing value. The book serves as a valuable resource for neurology residents, general medicine residents, epilepsy fellows, budding neurologists, epileptologists, and neurotechnologists by translating bedside observations into meaningful diagnostic insights. Emphasis is placed on real-world application, helping readers correlate seizure behaviors with underlying neuroanatomy and an approach to history taking. By strengthening clinical acumen and improving seizure recognition, this book ultimately supports accurate diagnosis, timely referral, and optimal management, thereby enhancing the quality of care delivered to patients with epilepsy and related seizure disorders.
Hasan, Ashfaq
The Principles of Pulmonary Diagnosis: Critical Concepts and a Structured Approach Book
1, Springer Nature Singapore, 2025, ISBN: 9789819678105.
@book{Hasan_2025,
title = {The Principles of Pulmonary Diagnosis: Critical Concepts and a Structured Approach},
author = { Ashfaq Hasan},
url = {https://link.springer.com/book/10.1007/978-981-96-7810-5},
doi = {10.1007/978-981-96-7810-5},
isbn = {9789819678105},
year = {2025},
date = {2025-11-23},
urldate = {2025-11-23},
publisher = {Springer Nature Singapore},
edition = {1},
abstract = {By closely integrating pathophysiological concepts into the diagnostic process, this book adopts a strong analytical approach to the diagnosis of pulmonary diseases. A syndrome-based calibrated strategy takes into account confusing similarities and emphasizes key differences between diseases, and helps build valuable concepts that serve the clinician in unravelling diagnostic dilemmas in real-world settings.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
By closely integrating pathophysiological concepts into the diagnostic process, this book adopts a strong analytical approach to the diagnosis of pulmonary diseases. A syndrome-based calibrated strategy takes into account confusing similarities and emphasizes key differences between diseases, and helps build valuable concepts that serve the clinician in unravelling diagnostic dilemmas in real-world settings.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.
Dedicated chapters illustrate how the incorporation of critical thinking strategies into the diagnostic reasoning process helps formulate a pragmatic differential diagnosis from a broad range of candidate conditions, with logical progression to the most likely diagnosis.
The unique format of this book provides an excellent framework for teaching, and for enhancing the diagnostic acumen of students of Pulmonary and Internal Medicine. This format also makes the book an ideal quick-reference source for pulmonologists and physicians in clinical practice.
2024
Hussain, Mohammed Raheem
Respiratory Medicine Made Simplified Book
1st, AkiNik Publications, 169, C-11, Sector-3, Rohini-110085, New Delhi, India., 2024, ISBN: 9789361351266.
@book{2024,
title = {Respiratory Medicine Made Simplified},
author = {Mohammed Raheem Hussain},
url = {https://www.akinik.com/products/3112/respiratory-medicine-made-simplified},
doi = {10.22271/ed.book.3112},
isbn = {9789361351266},
year = {2024},
date = {2024-11-25},
urldate = {2024-11-01},
booktitle = {Respiratory Medicine Made Simplified},
publisher = {AkiNik Publications},
address = {169, C-11, Sector-3, Rohini-110085, New Delhi, India.},
edition = {1st},
abstract = {Respiratory medicine plays a vital role in healthcare, addressing diseases that impact breathing and lung function. This simplified guide breaks down complex respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and respiratory infections. It covers essential aspects, including pathophysiology, diagnostic approaches, treatment strategies, and preventive measures. By simplifying medical concepts, this resource aims to enhance understanding for medical students, healthcare practitioners, and general readers interested in respiratory health and disease management.},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Respiratory medicine plays a vital role in healthcare, addressing diseases that impact breathing and lung function. This simplified guide breaks down complex respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and respiratory infections. It covers essential aspects, including pathophysiology, diagnostic approaches, treatment strategies, and preventive measures. By simplifying medical concepts, this resource aims to enhance understanding for medical students, healthcare practitioners, and general readers interested in respiratory health and disease management.
2023
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology Theory/Practical skills,Viva Book
3rd, Paras Medical Books Pvt. Ltd., Hyderabad, 2023, ISBN: 978-81-95819-17-1.
@book{Ahmed_2023,
title = {Forensic Medicine and Toxicology Theory/Practical skills,Viva},
author = {Khazi Mudabbir Ahmed},
isbn = {978-81-95819-17-1},
year = {2023},
date = {2023-01-01},
booktitle = {Forensic Medicine and Toxicology Theory/Practical skills,Viva},
publisher = {Paras Medical Books Pvt. Ltd.},
address = {Hyderabad},
edition = {3rd},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2021
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology Theory/Practical Skills, Viva Book
2nd, Paras Medical Books Pvt. Ltd., Hyderabad, 2021, ISBN: 978-8195271580.
@book{Ahmed_2021c,
title = {Forensic Medicine and Toxicology Theory/Practical Skills, Viva},
author = {Khazi Mudabbir Ahmed},
isbn = {978-8195271580},
year = {2021},
date = {2021-01-01},
urldate = {2021-01-01},
booktitle = {Forensic Medicine and Toxicology Theory/Practical Skills, Viva},
publisher = {Paras Medical Books Pvt. Ltd.},
address = {Hyderabad},
edition = {2nd},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2020
Khaleel, Mohammed
Handbook on Novel Coronavirus: What You Need to Know? Book
1st, IP Innovative Publication Pvt. Ltd., New Delhi, 2020, ISBN: 9789388022491.
@book{Khaleel_2020,
title = {Handbook on Novel Coronavirus: What You Need to Know?},
author = {Mohammed Khaleel},
url = {https://www.ipinnovative.com/books-details/132-NDM1NzE0Mjg1NzE=},
isbn = {9789388022491},
year = {2020},
date = {2020-06-30},
booktitle = {Handbook on Novel Coronavirus: What You Need to Know?},
publisher = {IP Innovative Publication Pvt. Ltd.},
address = {New Delhi},
edition = {1st},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2018
Ahmed, Khazi Mudabbir
Forensic Medicine and Toxicology (Theory/Practical and Viva) Book
1st, Paras Medical Books Pvt. Ltd., Hyderabad, 2018, ISBN: 978-93-86480-17-0.
@book{Ahmed_2018c,
title = {Forensic Medicine and Toxicology (Theory/Practical and Viva)},
author = {Khazi Mudabbir Ahmed},
isbn = {978-93-86480-17-0},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
booktitle = {Forensic Medicine and Toxicology},
publisher = {Paras Medical Books Pvt. Ltd.},
address = {Hyderabad},
edition = {1st},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2016
Hasan, Ashfaq
The Slow Stain Book
2nd, Ashfaq Hasan, Hyderabad, 2016, ISBN: 9879352671144.
@book{Hasan_2016,
title = {The Slow Stain},
author = {Ashfaq Hasan},
isbn = {9879352671144},
year = {2016},
date = {2016-01-01},
booktitle = {The Slow Stain},
publisher = {Ashfaq Hasan},
address = {Hyderabad},
edition = {2nd},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2013
Mathur, Shobhana
Principles of Pharmacology for B.Sc. Nursing Book
2nd, Frontline Publications, 2013, ISBN: 9788189966140.
@book{Mathur_2013,
title = {Principles of Pharmacology for B.Sc. Nursing},
author = {Shobhana Mathur},
isbn = { 9788189966140},
year = {2013},
date = {2013-01-01},
booktitle = {Principles of Pharmacology for B.Sc. Nursing},
publisher = {Frontline Publications},
edition = {2nd},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Hasan, Ashfaq
Handbook of Blood Gas/Acid-Base Interpretation Book
Springer London, 2013, ISBN: 9781447143154.
@book{Hasan_2013,
title = {Handbook of Blood Gas/Acid-Base Interpretation},
author = {Ashfaq Hasan},
url = {https://link.springer.com/book/10.1007/978-1-4471-4315-4},
doi = {10.1007/978-1-4471-4315-4},
isbn = {9781447143154},
year = {2013},
date = {2013-01-01},
urldate = {2013-01-01},
booktitle = {Handbook of Blood Gas/Acid-Base Interpretation},
publisher = {Springer London},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Hasan, Ashfaq
Zrozumiec wentylacje mechaniczna Book
Medipage, Warszawa, 2013, ISBN: 9788361104773.
@book{Hasan_2013b,
title = {Zrozumiec wentylacje mechaniczna},
author = {Ashfaq Hasan},
editor = {Dariusz Meciejewski [Translation from English to Polish]},
isbn = {9788361104773},
year = {2013},
date = {2013-01-01},
booktitle = {Zrozumiec wentylacje mechaniczna},
publisher = {Medipage},
address = {Warszawa},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Mrudula, Chandrupatla
Handbook of Muscles Book
3rd, Osmania Medical Publishers, Hyderabad, 2013.
@book{Mrudula_2013,
title = {Handbook of Muscles},
author = {Chandrupatla Mrudula},
year = {2013},
date = {2013-01-01},
booktitle = {Handbook of Muscles},
publisher = {Osmania Medical Publishers},
address = {Hyderabad},
edition = {3rd},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2012
Mrudula, Chandrupatla; Krishnaiah, M.
Concise Anatomy Book
1st (Reprint), Osmania Medical Publishers, Hyderabad, 2012.
@book{Mrudula_2012,
title = {Concise Anatomy},
author = {Chandrupatla Mrudula and M. Krishnaiah},
year = {2012},
date = {2012-01-01},
booktitle = {Concise Anatomy},
publisher = {Osmania Medical Publishers},
address = {Hyderabad},
edition = {1st (Reprint)},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
2010
Hasan, Ashfaq
Understanding mechanical ventilation Book
2, Springer-Verlag, London, England, 2010, ISBN: 978-1-84882-868-1.
@book{Hasan_2010,
title = {Understanding mechanical ventilation},
author = {Ashfaq Hasan},
isbn = {978-1-84882-868-1},
year = {2010},
date = {2010-01-01},
urldate = {2010-01-01},
booktitle = {Understanding mechanical ventilation},
publisher = {Springer-Verlag},
address = {London, England},
edition = {2},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Chapters Published in Books
2026
Ali, Shireen Adeeb Mujtaba; Amrin, Shaheen Siddiqua; Naveed, M. Aleemuddin; Mujahid, Mohammed Naseeruddin
Artificial intelligence-powered pipelines for therapeutic innovation Book Chapter
In: Boubaker, Olfa (Ed.): AI and Data Science in Medical Research, Chapter 9, pp. 243–262, Elsevier, 2026, ISBN: 9780443276385.
@inbook{Ali_2026c,
title = {Artificial intelligence-powered pipelines for therapeutic innovation},
author = {Shireen Adeeb Mujtaba Ali and Shaheen Siddiqua Amrin and M. Aleemuddin Naveed and Mohammed Naseeruddin Mujahid},
editor = {Olfa Boubaker},
url = {https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780443276385000110?via%3Dihub},
doi = {10.1016/b978-0-443-27638-5.00011-0},
isbn = {9780443276385},
year = {2026},
date = {2026-05-01},
urldate = {2026-05-01},
booktitle = {AI and Data Science in Medical Research},
issuetitle = {Medical Robots and Devices: New Developments and Advances},
pages = {243–262},
publisher = {Elsevier},
chapter = {9},
abstract = {The adoption of data science and artificial intelligence (AI) in pharmaceutical research signifies an unprecedented improvement in the speed at which new medicinal compounds are discovered and the efficiency of medication development processes. Due to the high failure rate, duration, and expense of traditional drug discovery procedures, creative solutions to improve efficacy and efficiency are required. By utilizing large datasets and sophisticated algorithms to identify novel therapeutic targets, anticipate drug interactions, and expedite clinical trial procedures, AI and data science provide effective methods to tackle these problems. AI-driven algorithms, such as machine learning and deep learning, make it possible to analyze complicated biological data and find possible drug candidates and biomarkers with previously unheard-of speed and precision. These models have the ability to combine diverse data sources, including clinical, proteomic, and genetic data, to produce useful insights and forecast treatment effectiveness. In addition, data science approaches help to optimize drug development pipelines through enhanced target validation, optimized lead compounds, and customized treatment plans according to individual patient profiles. By utilizing these technologies, scientists may improve the accuracy of preclinical and clinical studies, expedite the release of new and effective treatments into the market, and drastically cut the time and expense associated with drug discovery. This chapter examines the revolutionary influence of AI and data science on drug discovery and development, which also highlights important approaches, case examples, and potential future prospects for utilizing these technologies in the search for novel medicines.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
The adoption of data science and artificial intelligence (AI) in pharmaceutical research signifies an unprecedented improvement in the speed at which new medicinal compounds are discovered and the efficiency of medication development processes. Due to the high failure rate, duration, and expense of traditional drug discovery procedures, creative solutions to improve efficacy and efficiency are required. By utilizing large datasets and sophisticated algorithms to identify novel therapeutic targets, anticipate drug interactions, and expedite clinical trial procedures, AI and data science provide effective methods to tackle these problems. AI-driven algorithms, such as machine learning and deep learning, make it possible to analyze complicated biological data and find possible drug candidates and biomarkers with previously unheard-of speed and precision. These models have the ability to combine diverse data sources, including clinical, proteomic, and genetic data, to produce useful insights and forecast treatment effectiveness. In addition, data science approaches help to optimize drug development pipelines through enhanced target validation, optimized lead compounds, and customized treatment plans according to individual patient profiles. By utilizing these technologies, scientists may improve the accuracy of preclinical and clinical studies, expedite the release of new and effective treatments into the market, and drastically cut the time and expense associated with drug discovery. This chapter examines the revolutionary influence of AI and data science on drug discovery and development, which also highlights important approaches, case examples, and potential future prospects for utilizing these technologies in the search for novel medicines.
Ali, Shireen Adeeb Mujtaba; Mujiburrehman, Shaikh Shagufta; Vazirizadeh, Amir; Barwant, Mukul Machhindra
Microbial innovations in the fight against hunger Book Chapter
In: Babaniyi, Babafemi Raphael; Sawicka, Barbara; Barwant, Mukul Machhindra; Aransiola, Sesan Abiodun (Ed.): Leveraging Microbial Technology for Food Security, Chapter 6, pp. 84–104, CRC Press, 1st, 2026, ISBN: 9781003650881.
@inbook{Ali_2026b,
title = {Microbial innovations in the fight against hunger},
author = {Shireen Adeeb Mujtaba Ali and Shaikh Shagufta Mujiburrehman and Amir Vazirizadeh and Mukul Machhindra Barwant},
editor = {Babafemi Raphael Babaniyi and Barbara Sawicka and Mukul Machhindra Barwant and Sesan Abiodun Aransiola},
url = {https://www.taylorfrancis.com/chapters/edit/10.1201/9781003650881-6/microbial-innovations-fight-hunger-shireen-adeeb-mujtaba-ali-shaikh-shagufta-mujiburrehman-amir-vazirizadeh-mukul-machhindra-barwant},
doi = {10.1201/9781003650881-6},
isbn = {9781003650881},
year = {2026},
date = {2026-04-22},
urldate = {2026-04-01},
booktitle = {Leveraging Microbial Technology for Food Security},
pages = {84–104},
publisher = {CRC Press},
edition = {1st},
chapter = {6},
abstract = {As the global population continues to rise and resources become increasingly limited, hunger remains a critical challenge, projected to worsen by 2050. Ensuring a sustainable and sufficient food supply requires innovative solutions, with microbiology playing a key role in enhancing food production, quality, safety, and nutrition, contributing to the United Nations Zero Hunger goal. Microorganisms are essential to agriculture, food processing, and health, offering ecofriendly alternatives to chemical-intensive methods. Beneficial microbes such as nitrogen-fixing bacteria, mycorrhizal fungi, and phosphate-solubilizing bacteria improve soil fertility, increasing crop yield and sustainability. Biopesticides and biofertilizers reduce reliance on synthetic chemicals, promoting healthier ecosystems. This chapter explores the diversity and applications of microorganisms in agriculture, food, and health, emphasizing their immense potential in solving global food challenges. By harnessing microbial breakthroughs, we can develop sustainable solutions to combat hunger and create a resilient global food system.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
As the global population continues to rise and resources become increasingly limited, hunger remains a critical challenge, projected to worsen by 2050. Ensuring a sustainable and sufficient food supply requires innovative solutions, with microbiology playing a key role in enhancing food production, quality, safety, and nutrition, contributing to the United Nations Zero Hunger goal. Microorganisms are essential to agriculture, food processing, and health, offering ecofriendly alternatives to chemical-intensive methods. Beneficial microbes such as nitrogen-fixing bacteria, mycorrhizal fungi, and phosphate-solubilizing bacteria improve soil fertility, increasing crop yield and sustainability. Biopesticides and biofertilizers reduce reliance on synthetic chemicals, promoting healthier ecosystems. This chapter explores the diversity and applications of microorganisms in agriculture, food, and health, emphasizing their immense potential in solving global food challenges. By harnessing microbial breakthroughs, we can develop sustainable solutions to combat hunger and create a resilient global food system.
2025
Ali, Shireen Adeeb Mujtaba; Begum, Safia; Naveed, M. Aleemuddin; Mujahid, Mohammed Naseeruddin
Precision Healthcare: Advancing Patient Care Through Decision Tools, Wearables, and Ethical Considerations Book Chapter
In: Gupta, Neeraj; Ibrahim, Abdelhameed; Vyas, Bhavesh; Jeet, Shobhna (Ed.): Precision Healthcare: Patient Care, Decision Tools, Wearables, Legal and Ethical Issues, pp. 195–205, BENTHAM SCIENCE PUBLISHERS, 2025, ISBN: 9798898813512.
@inbook{Ali_2025c,
title = {Precision Healthcare: Advancing Patient Care Through Decision Tools, Wearables, and Ethical Considerations},
author = {Shireen Adeeb Mujtaba Ali and Safia Begum and M. Aleemuddin Naveed and Mohammed Naseeruddin Mujahid},
editor = {Neeraj Gupta and Abdelhameed Ibrahim and Bhavesh Vyas and Shobhna Jeet},
url = {https://www.eurekaselect.com/chapter/26828},
doi = {10.2174/9798898813512125010015},
isbn = {9798898813512},
year = {2025},
date = {2025-12-19},
urldate = {2025-12-19},
booktitle = {Precision Healthcare: Patient Care, Decision Tools, Wearables, Legal and Ethical Issues},
pages = {195–205},
publisher = {BENTHAM SCIENCE PUBLISHERS},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2023
Reddy, Uppin Narayan
Allergen Immunotherapy Book Chapter
In: Kumar, R. Remesh; Mohan, R. Krishna; Gupta, Neeraj; Ashok, Narmada (Ed.): IAP Case Based Reviews in Pediatric Allergy, Chapter 41, pp. 328-334, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, 1st, 2023, ISBN: 9789354659898.
@inbook{Reddy_2023,
title = {Allergen Immunotherapy},
author = {Uppin Narayan Reddy},
editor = {R. Remesh Kumar and R. Krishna Mohan and Neeraj Gupta and Narmada Ashok},
url = {https://jaypeebrothers.com/pgDetails.aspx?cat=s&book_id=9789354659898},
isbn = {9789354659898},
year = {2023},
date = {2023-01-01},
booktitle = {IAP Case Based Reviews in Pediatric Allergy},
pages = {328-334},
publisher = {Jaypee Brothers Medical Publishers (P) Ltd},
address = {New Delhi},
edition = {1st},
chapter = {41},
organization = {Indian Academy of Pediatrics},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2022
Haneef, Nayeem Sadath
Alopecia areata Book Chapter
In: Sacchidanand, S.; Savitha, A. S.; Shilpa, K.; Kumar, B. M. Shashi (Ed.): IADVL textbook of dermatology, Bhalani Publishing House, Mumbai, 5th, 2022, ISBN: 9789381496701.
@inbook{Haneef_2022,
title = {Alopecia areata},
author = {Nayeem Sadath Haneef},
editor = {S. Sacchidanand and A. S. Savitha and K. Shilpa and B. M. Shashi Kumar},
isbn = {9789381496701},
year = {2022},
date = {2022-01-01},
booktitle = {IADVL textbook of dermatology},
publisher = {Bhalani Publishing House},
address = {Mumbai},
edition = {5th},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2021
Nasirabadi, Minhajzafar; Reddy, V. George; Akula, Vishal
COVID 19 Pandemic and Telemedicine Practice in India Book Chapter
In: Brahma, Arabinda; Reddy, George V.; Sarkhel, Sujit (Ed.): Parallel Pandemic of 2020, Chapter 5, pp. 56-70, Indian Psychiatric Society, Gurugram, 1st, 2021, ISBN: 9798772377505.
@inbook{Nasirabadi_2021c,
title = {COVID 19 Pandemic and Telemedicine Practice in India},
author = {Minhajzafar Nasirabadi and V. George Reddy and Vishal Akula},
editor = {Arabinda Brahma and George V. Reddy and Sujit Sarkhel},
url = {https://deemagclinic.com/2021/12/07/parallel-pandemic-of-2020/},
isbn = {9798772377505},
year = {2021},
date = {2021-07-12},
booktitle = {Parallel Pandemic of 2020},
pages = {56-70},
publisher = {Indian Psychiatric Society},
address = {Gurugram},
edition = {1st},
chapter = {5},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Mukheem, Abdul; Shahabuddin, Syed; Khan, Aleem Ahmed; Hossain, Md. Murad; Jasni, Ainil Hawa; Sridewi, Nanthini
Bio-plastic polyhydroxyalkanoate (PHA): Applications in modern medicine Book Chapter
In: Kuddus, Mohammed; Roohi, (Ed.): Bioplastics for Sustainable Development, Chapter 8, pp. 231-257, Springer Singapore, 2021, ISBN: 9789811618239.
@inbook{Mukheem_2021,
title = {Bio-plastic polyhydroxyalkanoate (PHA): Applications in modern medicine},
author = {Abdul Mukheem and Syed Shahabuddin and Aleem Ahmed Khan and Md. Murad Hossain and Ainil Hawa Jasni and Nanthini Sridewi},
editor = {Mohammed Kuddus and Roohi},
url = {https://link.springer.com/chapter/10.1007/978-981-16-1823-9_8},
doi = {10.1007/978-981-16-1823-9_8},
isbn = {9789811618239},
year = {2021},
date = {2021-06-22},
urldate = {2021-01-01},
booktitle = {Bioplastics for Sustainable Development},
pages = {231-257},
publisher = {Springer Singapore},
chapter = {8},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Manorenj, Sandhya; Shaik, Reshma Sultana
Clinical aspects of Moyamoya disease. In: Moyamoya disease- a disease to count on in your daily practice Book Chapter
In: Chapter 3, IntechOpen, 2021, ISBN: 978-1-83968-387-9.
@inbook{Manorenj_2021d,
title = {Clinical aspects of Moyamoya disease. In: Moyamoya disease- a disease to count on in your daily practice},
author = {Sandhya Manorenj and Reshma Sultana Shaik},
url = {https://www.intechopen.com/chapters/75446},
doi = {10.5772/intechopen.92950},
isbn = {978-1-83968-387-9},
year = {2021},
date = {2021-02-26},
urldate = {2021-02-26},
publisher = {IntechOpen},
chapter = {3},
abstract = {Moyamoya disease is a chronic progressive, non-atherosclerotic, occlusive intracranial vasculopathy involving major cerebral arteries around the circle of Willis. MMD occurs frequently in East Asian populations but the disease can affect the American and European ethnicities as well. Knowledge of clinical aspects of Moyamoya disease (MMD) is important in view of distinctive clinical presentation observed in children and adults. MMD has bimodal age of distribution, with peaks in the first and last decades of life. Childhood MMD is characterised by Ischemic manifestation (Transient ischemic attack, Cerebral Infarction), whereas adult MMD presents with hemorrhagic manifestations (Intracerebral haemorrhage, Intraventricular bleed). Refractory headache, seizure and ophthalmological abnormalities are other clinical presentations of MMD. A high index of clinical suspicion and an eye to recognise the common as well as unusual manifestations of the disease and inciting events may prevent delay in the diagnosis. A thorough knowledge about the varied clinical presentation would aid clinician for early diagnosis and management of this rare entity. The present article provides extensive review on the clinical aspects of MMD amongst adults and paediatric population, on the basis of previous articles and research studies.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Moyamoya disease is a chronic progressive, non-atherosclerotic, occlusive intracranial vasculopathy involving major cerebral arteries around the circle of Willis. MMD occurs frequently in East Asian populations but the disease can affect the American and European ethnicities as well. Knowledge of clinical aspects of Moyamoya disease (MMD) is important in view of distinctive clinical presentation observed in children and adults. MMD has bimodal age of distribution, with peaks in the first and last decades of life. Childhood MMD is characterised by Ischemic manifestation (Transient ischemic attack, Cerebral Infarction), whereas adult MMD presents with hemorrhagic manifestations (Intracerebral haemorrhage, Intraventricular bleed). Refractory headache, seizure and ophthalmological abnormalities are other clinical presentations of MMD. A high index of clinical suspicion and an eye to recognise the common as well as unusual manifestations of the disease and inciting events may prevent delay in the diagnosis. A thorough knowledge about the varied clinical presentation would aid clinician for early diagnosis and management of this rare entity. The present article provides extensive review on the clinical aspects of MMD amongst adults and paediatric population, on the basis of previous articles and research studies.
2019
Hasan, Ashfaq
History of TB: Robert Koch and Beyond Book Chapter
In: Hasnain, Seyed Ehtesham; Ehtesham, Nasreen Z.; Grover, Sonam (Ed.): Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions, Chapter 1, pp. 3-16, Springer Singapore, 2019, ISBN: 9789813294134.
@inbook{Hasan_2019,
title = {History of TB: Robert Koch and Beyond},
author = {Ashfaq Hasan},
editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover},
url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_1},
doi = {10.1007/978-981-32-9413-4_1},
isbn = {9789813294134},
year = {2019},
date = {2019-12-01},
urldate = {2019-01-01},
booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions},
pages = {3-16},
publisher = {Springer Singapore},
chapter = {1},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Hasan, Ashfaq; Praveen, Sai Haranath; Tarke, Chandrakant; Breik, Fahad Abdullah Bin
Clinical Aspects and Principles of Management of Tuberculosis Book Chapter
In: Hasnain, Seyed Ehtesham; Ehtesham, Nasreen Z.; Grover, Sonam (Ed.): Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions, Chapter 20, pp. 355-374, Springer Singapore, 2019, ISBN: 9789813294134.
@inbook{Hasan_2019b,
title = {Clinical Aspects and Principles of Management of Tuberculosis},
author = {Ashfaq Hasan and Sai Haranath Praveen and Chandrakant Tarke and Fahad Abdullah Bin Breik},
editor = {Seyed Ehtesham Hasnain and Nasreen Z. Ehtesham and Sonam Grover},
url = {https://link.springer.com/chapter/10.1007/978-981-32-9413-4_20},
doi = {10.1007/978-981-32-9413-4_20},
isbn = {9789813294134},
year = {2019},
date = {2019-12-01},
urldate = {2019-01-01},
booktitle = {Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions},
pages = {355-374},
publisher = {Springer Singapore},
chapter = {20},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Srinivas, Putta; Haneef, Nayeem Sadath
Code of medical ethics Book Chapter
In: Mysore, Venkataram; Bhat, Satish; Sirur, Subodh Premanand (Ed.): Medico-legal aspects of dermatology and plastic surgery, Chapter 3, pp. 22-37, Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, 1st, 2019, ISBN: 9789352708970.
@inbook{Haneef_2019,
title = {Code of medical ethics},
author = {Putta Srinivas and Nayeem Sadath Haneef },
editor = {Venkataram Mysore and Satish Bhat and Subodh Premanand Sirur},
doi = {10.5005/jp/books/18187_4},
isbn = {9789352708970},
year = {2019},
date = {2019-01-01},
booktitle = {Medico-legal aspects of dermatology and plastic surgery},
pages = {22-37},
publisher = {Jaypee Brothers Medical Publishers (P) Ltd},
address = {New Delhi},
edition = {1st},
chapter = {3},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2017
Khan, Aleem Ahmed; Vishwakarma, Sandeep Kumar; Bardia, Avinash; Habeeb, Md. Aejaz; Dhayal, M.
Repopulation of cirrhotic liver by hepatic stem/progenitor cells Book Chapter
In: Muriel, Pablo (Ed.): Liver Pathophysiology: Therapies and Antioxidants, Chapter 59, pp. 817-836, Academic Press, Boston, 2017, ISBN: 9780128042748.
@inbook{Khan_2017d,
title = {Repopulation of cirrhotic liver by hepatic stem/progenitor cells},
author = {Aleem Ahmed Khan and Sandeep Kumar Vishwakarma and Avinash Bardia and Md. Aejaz Habeeb and M. Dhayal},
editor = {Pablo Muriel},
url = {https://www.sciencedirect.com/science/article/abs/pii/B978012804274800059X?via%3Dihub},
doi = {10.1016/b978-0-12-804274-8.00059-x},
isbn = {9780128042748},
year = {2017},
date = {2017-01-01},
urldate = {2017-01-01},
booktitle = {Liver Pathophysiology: Therapies and Antioxidants},
pages = {817-836},
publisher = {Academic Press},
address = {Boston},
chapter = {59},
abstract = {Liver cirrhosis is one of the major causes of morbidity and mortality worldwide. Liver transplantation is the only successful and curative option for the management of this disease. However, cost effectiveness, timely availability, operative risks, need of life-long immunosuppressant, and shortage of donor organs are major challenges to fulfill the demand. Stem cells transplantation has emerged as a bridge to liver transplantation for the repopulation of cirrhotic liver due to its potential for long-term proliferation. Human fetal liver–derived stem/progenitor cells (fLSPCs) are emerging as safe and effective therapeutic possibility in the management of liver cirrhosis due to their low immunogenicity and high proliferative ability. Combination of mesenchymal stem cells with fLSPCs could be the best option to ameliorate immunomodulation, fibrotic reconstruction, and repopulation of lost hepatocytes to replenish the deficient liver functions. Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Liver cirrhosis is one of the major causes of morbidity and mortality worldwide. Liver transplantation is the only successful and curative option for the management of this disease. However, cost effectiveness, timely availability, operative risks, need of life-long immunosuppressant, and shortage of donor organs are major challenges to fulfill the demand. Stem cells transplantation has emerged as a bridge to liver transplantation for the repopulation of cirrhotic liver due to its potential for long-term proliferation. Human fetal liver–derived stem/progenitor cells (fLSPCs) are emerging as safe and effective therapeutic possibility in the management of liver cirrhosis due to their low immunogenicity and high proliferative ability. Combination of mesenchymal stem cells with fLSPCs could be the best option to ameliorate immunomodulation, fibrotic reconstruction, and repopulation of lost hepatocytes to replenish the deficient liver functions. Merging of nanotechnology and whole-liver bioengineering approaches could provide several unanswered questions of regenerative mechanisms and developing extracorporeal liver systems.
2014
Hasan, Ashfaq; Uzma, Nazia; Kumar, Bhaskarpillai Santhosh
Obstructive sleep apnea and the metabolic syndrome: Clinical profiles and relationships Book Chapter
In: Watson, Ronald Ross (Ed.): Modulation of sleep by obesity, diabetes, age, and diet, Chapter 16, pp. 139-147, Academic Press, 1st, 2014, ISBN: 9780128103074.
@inbook{nokey,
title = {Obstructive sleep apnea and the metabolic syndrome: Clinical profiles and relationships},
author = {Ashfaq Hasan and Nazia Uzma and Bhaskarpillai Santhosh Kumar},
editor = {Ronald Ross Watson},
url = {https://www.elsevier.com/books/modulation-of-sleep-by-obesity-diabetes-age-and-diet/watson/978-0-12-420168-2},
isbn = {9780128103074},
year = {2014},
date = {2014-09-14},
urldate = {2014-09-14},
booktitle = {Modulation of sleep by obesity, diabetes, age, and diet},
pages = {139-147},
publisher = {Academic Press},
edition = {1st},
chapter = {16},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2013
Paspala, Syed Ameer Basha; Khan, Aleem Ahmed; Vishwakarma, Sandeep; Murthy, T. V. Ramakrishna
Pluripotent stem cells for neural regeneration Book Chapter
In: Danquah, Michael K.; Mahato, Ram I. (Ed.): Emerging Trends in Cell and Gene Therapy, Chapter 16, pp. 347-371, Humana Press, 2013, ISBN: 9781627034173.
@inbook{Paspala_2013,
title = {Pluripotent stem cells for neural regeneration},
author = {Syed Ameer Basha Paspala and Aleem Ahmed Khan and Sandeep Vishwakarma and T. V. Ramakrishna Murthy},
editor = {Michael K. Danquah and Ram I. Mahato},
url = {https://link.springer.com/chapter/10.1007/978-1-62703-417-3_16},
doi = {10.1007/978-1-62703-417-3_16},
isbn = {9781627034173},
year = {2013},
date = {2013-04-17},
urldate = {2013-01-01},
booktitle = {Emerging Trends in Cell and Gene Therapy},
pages = {347-371},
publisher = {Humana Press},
chapter = {16},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2012
Tripura, Chaturvedula; Khan, Aleem Ahmed; Pande, Gopal
Cell based therapy for chronic liver disease: Role of fetal liver cells in restoration of the liver cell functions Book Chapter
In: Baptista, Pedro M. (Ed.): Liver Regeneration, Chapter 12, InTechOpen, 2012, ISBN: 9789535106227.
@inbook{Tripura_2012,
title = {Cell based therapy for chronic liver disease: Role of fetal liver cells in restoration of the liver cell functions},
author = {Chaturvedula Tripura and Aleem Ahmed Khan and Gopal Pande},
editor = {Pedro M. Baptista},
url = {https://www.intechopen.com/chapters/36999},
doi = {10.5772/45876},
isbn = {9789535106227},
year = {2012},
date = {2012-05-16},
urldate = {2012-05-01},
booktitle = {Liver Regeneration},
publisher = {InTechOpen},
chapter = {12},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2010
Naimath, Parveen; Khan, Aleem Ahmed; Habeeb, Md. Aejaz; Habibullah, Chitoor Mohammed
Gastrointestinal stem cells Book Chapter
In: Appasani, Krishnarao; Appasani, Raghu K. (Ed.): Stem Cell Biology and Regenerative Medicine, Chapter 13, pp. 219-225, Humana Press, 2010, ISBN: 9781607618591.
@inbook{Parveen_2010,
title = {Gastrointestinal stem cells},
author = {Parveen Naimath and Aleem Ahmed Khan and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah},
editor = {Krishnarao Appasani and Raghu K. Appasani},
url = {https://link.springer.com/chapter/10.1007/978-1-60761-860-7_13},
doi = {10.1007/978-1-60761-860-7_13},
isbn = {9781607618591},
year = {2010},
date = {2010-11-01},
urldate = {2010-10-01},
booktitle = {Stem Cell Biology and Regenerative Medicine},
pages = {219-225},
publisher = {Humana Press},
chapter = {13},
abstract = {Stem cell research is advancing at an incredible pace, with new discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Stem cell research is advancing at an incredible pace, with new discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.