@article{Tabassum_2025,

title = {Diagnostic and prognostic significance of platelet indices and platelet lymphocyte ratio in covid vs dengue: an observational study},

author = {Asiya Tabassum and T. S. Shamshuddeen and Idrees Akhtar Afroze},

url = {https://journals.lww.com/jdrntruhs/fulltext/2025/01000/diagnostic_and_prognostic_significance_of_platelet.8.aspx},

doi = {10.4103/jdrntruhs.jdrntruhs_170_22},

issn = {2950-5348},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Journal of Dr. NTR University of Health Sciences},

volume = {14},

issue = {1},

pages = {46-51},

abstract = {Background: Both SARS-CoV and dengue virus share the same symptoms in the early stages and at times causing misdiagnosis, coinfections are common creating difficulties for the health care workers. Aim: Efforts were made to utilize the hematology parameters, Mean platelet volume and Platelet lymphocyte ratio (PLR) in early segregation, diagnosis and predicting the severity and prognosis of the cases and to determine, if further investigations or referrals would be required. Material and Methods: Observational study was conducted with 100 confirmed cases of COVID-19 and dengue patients. Results: Patients with COVID-19 present with leucopenia or leucocytosis, with Lymphopenia as the most significant finding, Platelet counts were adequate but Mean platelet volume (MPV) is insignificant and increased levels of PLR are related with bad prognosis. In Dengue, the white blood cells (WBC) count shows progressive leucopenia with lymphocytic predominance with atypical lymphocytes, thrombocytopenia with increased MPV and decreased PLR help in early diagnosis of dengue infection. Conclusion: Complete blood count (CBC) is the most common and inexpensive test performed in patients and has capacity to segregate and diagnose Covid 19 and Dengue cases at an early stage so that isolation and prompt treatment can be started early, decreasing the lead time and help in combating the pandemic. PLR and MPV can be used to predict the prognosis and complications and have usefulness in monitoring treatment response. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025g,

title = {Whispers of the ovary: a pathological journey through lymphangioma},

author = {Juveria Fatima and Naushaba Tazeen and Asiya Tabassum and Idrees Akhtar Afroze},

url = {https://journals.lww.com/tjima/fulltext/2025/01000/whispers_of_the_ovary__a_pathological_journey.14.aspx},

doi = {10.4103/tjima.tjima_15_25},

isbn = {3050-6158},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Telangana Journal of IMA},

volume = {5},

issue = {1},

pages = {44-47},

abstract = {Lymphangioma of the ovary is an exceedingly rare benign tumor, characterized by the proliferation of lymphatic vessels. Typically presenting in childhood or early adulthood, these lesions can often be asymptomatic but may occasionally lead to abdominal pain, pelvic mass, or complications such as torsion or hemorrhage. Diagnosis is primarily achieved through imaging techniques such as ultrasound, computed tomography, or magnetic resonance imaging, which help differentiate lymphangiomas from other ovarian masses. Histopathological examination is essential for definitive diagnosis, revealing cystic spaces lined by the endothelial cells and a lymphatic-like structure. Management usually involves surgical intervention, with complete excision being the preferred treatment to prevent recurrence. Given the rarity of ovarian lymphangiomas, there is limited literature on the long-term outcomes; however, most cases report favorable prognoses following appropriate surgical resection. This abstract aims to summarize the clinical features, diagnostic approaches, and treatment options for ovarian lymphangioma while emphasizing the need for awareness of this rare entity among clinicians to facilitate timely diagnosis and intervention. Further studies are warranted to better understand the pathogenesis and optimal management strategies for this unusual tumor.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naaz_2023,

title = {Clinico-pathological correlation of inflammatory dermatoses in a tertiary care hospital},

author = {Farha Naaz and Naushaba Tazeen and Mohammed Mustafa Khan and Idrees Akhtar Afroze and Khatija Shameem and Atiya Begum and Asiya Tabassum and Sobia Afreen},

url = {https://jcdronline.org/index.php/JCDR/article/view/4062/3938},

issn = {0975-3583},

year  = {2023},

date = {2023-12-06},

urldate = {2023-12-06},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {12},

pages = {2525-2534},

abstract = {Inflammatory dermatoses encompass a variety of histologic patterns that affect different segments of the skin. Skin is a complex organ having many functions. Epidermis with melanocytic system, dermis with adnexa and subcutis are its main components. Skin diseases are highly prevalent in developing countries, occur commonly amongst all age groups and range from simple inflammatory lesions to fatal neoplasms. As clinical presentation can be similar for various skin lesions, histopathological examination remains the gold standard for accurate diagnosis and serves as a guide to clinician for appropriate management. The objective of this study is to observe and analyze the spectrum of inflammatory dermatological lesions through Histopathological examination. Through this we try to find out the common skin lesions in an urban population, evaluate its correlation with age and gender, and correlate the clinical diagnosis and histopathological examination. Out of 50 skin biopsies studied, 31 were female and 19 were male. Age of the patients range from 11 to 70 years in which peak age was 21-30 years. Leprosy is the most common lesion in our study accounting for 16 out of 50 cases studied. Next common lesion was Psoriasis, accounting for 10 out of 50 cases studied. Out of these 50 cases, 44 cases correlated with clinical diagnosis and the rest of cases did not correlate with given clinical diagnosis. The present study emphasizes the role of histopathological examination as a valuable diagnostic tool to understand the pathology of inflammatory dermatoses and provides a significant insight into trend of inflammatory skin lesions in the specific sub-population of Hyderabad, Telangana, India.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023b,

title = {Role of Ag NOR staining in benign and malignant lesions of prostate at a tertiary hospital },

author = {Mohammed Ghouse Mohiddin and Mohammed Mustafa Khan and Mohammed Masooduddin and Asiya Tabassum},

url = {https://www.jcdronline.org/paper.php?slug=role-of-ag-nor-staining-in-benign-and-malignant-lesions-of-prostate-at-a-tertiary-hospital},

issn = {0975-3583},

year  = {2023},

date = {2023-08-31},

urldate = {2023-08-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {8},

pages = {2600-2608},

abstract = {Nucleolar organizing regions (NOR) can be located by staining with silver nitrate under prescribed conditions; the structures thus demonstrated termed as `AgNORs'. Nucleolar organizing regions (NOR) counts might be of helpful specifically in conditions where histological distinction of prostatic cancer is difficult. Present study was aimed to study role of AgNORs in differentiating benign from malignant lesions of prostate. Material and Methods:Present study was single-center, prospective, observational study, conducted in samples of prostatic biopsies. The diagnosis in all cases were made on H & E and subsequently taken up for study.All prostatic biopsies were stained by the modified AgNOR technique. All silver-stained structures, both intra and extra nucleolar were counted.Results: Based on the histopathological examination of prostatic biopsies, 87 were diagnosed as benign (BPH) and 13 cases were malignant (Carcinoma prostate). Maximum no. of cases of BPH are in the age group of 51 - 60 years (40.2 %) followed by 61-70 years (39.1 %). Majority cases of carcinoma prostate were from age group of 51 - 60 years (38.46 %). In the present study we have applied AgNOR staining procedure to histopathologically diagnosed cases of BPH and Ca prostate. In BPH showed a mean AgNOR count of 2.38 ± 0.31, while biopsies from carcinoma prostate had a mean AgNOR count of 5.39 ±0.408. In our study BPH constituted majority of the lesions (87% of cases). Among BPH lesions, BPH with prostatitis constituted (29 %) which obscures the AgNOR staining. Ca prostate constituted (13%). Conclusion: Prostatic disease is responsible for significant morbidity and mortality in men throughout the world. AgNOR is a simple, cost effective and easy stain to evaluate the proliferative activity of different prostatic lesions},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023c,

title = {Frozen section evaluation and clinicopathological correlation of sentinel lymph nodes in breast carcinoma},

author = {Mohammed Ghouse Mohiddin and Asiya Tabassum and Maryam Fatima and T. S. Shamshuddeen},

url = {https://www.makhillpublications.co/files/published-files/mak-rjms/2023/3-302-306.pdf},

doi = {10.59218/makrjms.2023.302.306},

issn = {1815-9346},

year  = {2023},

date = {2023-07-03},

urldate = {2023-07-03},

journal = {Research Journal of Medical Sciences},

volume = {17},

issue = {3},

pages = {302-306},

abstract = {The evaluation of sentinel lymph nodes (SLNs) plays a crucial role in the management and prognosis of breast carcinoma. This study aimed to investigate the utility of frozen section evaluation in assessing SLNs and its clinicopathological correlation in breast carcinoma patients. A retrospective analysis was conducted on a cohort of breast carcinoma patients who underwent SLN biopsy and frozen section evaluation. The frozen sections were evaluated for the presence of metastatic deposits and the results were compared with the final histopathological examination of the SLNs. The utility of frozen section evaluation in assessing sentinel lymph nodes (SLNs) based on the final histopathology results. The table indicates a significant association between frozen section evaluation and final histopathology, highlighting the value of frozen section evaluation in assessing SLNs. The concordance between frozen section evaluation and the final histopathological examination of SLNs regarding the presence or absence of metastatic deposits. The significant association between frozen section evaluation and metastatic deposits suggests the reliability of frozen section evaluation in detecting metastasis in SLNs. The clinicopathological parameters associated with SLN involvement. The significant correlations observed between Tumor Size, Histological Grade, Hormone Receptor Status, Lymphovascular Invasion and SLN involvement emphasize the importance of these parameters in predicting SLN involvement in breast carcinoma patients. These findings contribute to clinical decision‐making and management strategies for patients with breast carcinoma. Frozen section evaluation of SLNs in breast carcinoma provides valuable intraoperative information for immediate decision‐making regarding axillary lymph node dissection. It demonstrates high accuracy in detecting metastatic involvement of SLNs. The clinicopathological correlation of frozen section results with various tumor characteristics helps in better understanding the disease progression and optimizing patient management. Further prospective studies are warranted to validate these findings and refine the clinical application of frozen section evaluation in breast carcinoma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Raheem_2022b,

title = {Role of neutrophil-lymphocyte ratio as a predictive marker in the diagnosis of acute coronary syndrome},

author = {Mariyah Raheem and Asiya Tabassum and Atiya Begum},

url = {https://www.ijsr.net/getabstract.php?paperid=SR22728102305},

issn = {2319-7064},

year  = {2022},

date = {2022-08-31},

urldate = {2022-08-31},

journal = {International Journal of Science and Research},

volume = {11},

issue = {8},

pages = {257-261},

abstract = {Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight femalepreponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if P<0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022b,

title = {Covid-19 vs dengue-role of WBC counts in segregation of cases at an early stage with special reference to NLR as a diagnostic and prognostic factor},

author = {Asiya Tabassum and Idrees Akhtar Afroze and Sumayya Begum },

url = {https://www.ijmsir.com/asset/images/uploads/16560077756647.pdf},

issn = {2458-868X},

year  = {2022},

date = {2022-05-31},

urldate = {2022-05-31},

journal = {International Journal of Medical Science and Innovative Research},

volume = {7},

issue = {3},

pages = {155-162},

abstract = {Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the

initial stages but have different clinical management which makes it challenging for the health care  professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done

decreasing the mortality and for better outcome of these patients. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shamshuddeen_2022,

title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},

author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},

url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},

doi = {10.53730/ijhs.v6ns3.7623},

issn = {2550-696X},

year  = {2022},

date = {2022-05-20},

urldate = {2022-05-20},

journal = {International Journal of Health Sciences},

volume = {6},

issue = {S3},

pages = {6963-6971},

publisher = {Universidad Tecnica de Manabi},

abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shamshuddeen_2022b,

title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},

author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},

url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},

doi = {10.53730/ijhs.v6nS3.7623 },

issn = {2550-696X},

year  = {2022},

date = {2022-05-09},

urldate = {2022-05-09},

journal = {International Journal of Health Sciences},

volume = {6},

issue = {S3},

pages = {6963-6971},

abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022,

title = {Evaluation of platelet indices in dengue seropositive cases at a tertiary care hospital in Hyderabad},

author = {Asiya Tabassum and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-platelet-indices-in-dengue-seropositive-cases-at-a-tertiary-care-hospital-in-hyderabad-_January_2022_8361510941_2433857.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2022},

date = {2022-01-31},

urldate = {2022-01-31},

journal = {International Journal of Scientific Research},

volume = {11},

issue = {1},

pages = {48-49},

abstract = {Background: Dengue is caused by an arbovirus and is transmitted by mosquito Aedes aegypti. In addition to platelet count, Platelet indices like Mean platelet volume (MPV), Platelet distribution width (PDW) ,Plateletcrit (PCT ) and Platelet large cell ratio (P-LCR) are being investigated as prospective platelet activation indicators. Aims And Objectives: To evaluate the role of platelet indices in dengue seropositive cases. Materials And Methods: This study was a retrospective one conducted on dengue seropositive cases in Department of pathology, Deccan College of medical sciences, Hyderabad. Cases were collected from Dept of medicine and pediatrics over a period of 2 months in Oct-Nov 2021. Blood samples were processed on Sysmex XN 550 automated cell counter and platelet counts were cross checked manually. Results: In this study, Out of 350 samples received, 1OO patients were found to be positive for dengue serology. Male: Female ratio was 1.3:1 with average age being 7.5years .60 % cases had platelet counts below 50,000/cumm. Among platelet indices, 72 % of the patients had mean platelet volume (MPV) less than 8.5; 84 % cases had Plateletcrit less than 0.22 %; 80 % had platelet distribution width (PDW) more than 25  and P-LCR was increased in 56% cases. Conclusion: We observed signicant correlation of low platelet count with MPV, PCT, PDW and P-LCR. MPV is a marker of platelet function and activation, high MPV indicates increased megakaryocytic activity whereas low MPV indicates marrow suppression. PDW is an indicator of platelet anisocytosis and has a negative correlation with low platelet count. P-LCR is inversely related to platelet count and directly related to PDW. It is decreased in patients with thrombocytosis and increased in thrombocytopenia. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}