@article{Raheem_2022b,

title = {Role of neutrophil-lymphocyte ratio as a predictive marker in the diagnosis of acute coronary syndrome},

author = {Mariyah Raheem and Asiya Tabassum and Atiya Begum},

url = {https://www.ijsr.net/getabstract.php?paperid=SR22728102305},

issn = {2319-7064},

year  = {2022},

date = {2022-08-31},

urldate = {2022-08-31},

journal = {International Journal of Science and Research},

volume = {11},

issue = {8},

pages = {257-261},

abstract = {Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight femalepreponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if P<0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022,

title = {Evaluation of platelet indices in dengue seropositive cases at a tertiary care hospital in Hyderabad},

author = {Asiya Tabassum and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-platelet-indices-in-dengue-seropositive-cases-at-a-tertiary-care-hospital-in-hyderabad-_January_2022_8361510941_2433857.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2022},

date = {2022-01-31},

urldate = {2022-01-31},

journal = {International Journal of Scientific Research},

volume = {11},

issue = {1},

pages = {48-49},

abstract = {Background: Dengue is caused by an arbovirus and is transmitted by mosquito Aedes aegypti. In addition to platelet count, Platelet indices like Mean platelet volume (MPV), Platelet distribution width (PDW) ,Plateletcrit (PCT ) and Platelet large cell ratio (P-LCR) are being investigated as prospective platelet activation indicators. Aims And Objectives: To evaluate the role of platelet indices in dengue seropositive cases. Materials And Methods: This study was a retrospective one conducted on dengue seropositive cases in Department of pathology, Deccan College of medical sciences, Hyderabad. Cases were collected from Dept of medicine and pediatrics over a period of 2 months in Oct-Nov 2021. Blood samples were processed on Sysmex XN 550 automated cell counter and platelet counts were cross checked manually. Results: In this study, Out of 350 samples received, 1OO patients were found to be positive for dengue serology. Male: Female ratio was 1.3:1 with average age being 7.5years .60 % cases had platelet counts below 50,000/cumm. Among platelet indices, 72 % of the patients had mean platelet volume (MPV) less than 8.5; 84 % cases had Plateletcrit less than 0.22 %; 80 % had platelet distribution width (PDW) more than 25  and P-LCR was increased in 56% cases. Conclusion: We observed signicant correlation of low platelet count with MPV, PCT, PDW and P-LCR. MPV is a marker of platelet function and activation, high MPV indicates increased megakaryocytic activity whereas low MPV indicates marrow suppression. PDW is an indicator of platelet anisocytosis and has a negative correlation with low platelet count. P-LCR is inversely related to platelet count and directly related to PDW. It is decreased in patients with thrombocytosis and increased in thrombocytopenia. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hussain_2021,

title = {Role of platelet-WBC ratio as a prognostic marker of cerebrovascular accident},

author = {Syed Arshad Hussain and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-plateletwbc-pwr-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_June_2021_6700252511_2520939.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2021},

date = {2021-06-01},

urldate = {2021-06-01},

journal = {International Journal of Scientific Research},

volume = {10},

issue = {6},

pages = {24-25},

abstract = {Cerebrovascular accidents are a leading cause of patient morbidity and mortality worldwide. The symptoms include sudden loss of vision,unconsciousness,weakness in contralateral upper and lower limbs, seizures and loss of vision. Several studies have concluded that the lower the platelet count and the higher the number of white blood cells in ischemic stroke patients will result in a more severe stroke and had worsen prognosis. Platelet and white blood cells counts can be converted into Platelet-to-White Blood Cell Ratio (PWR) which is a comparison between the number of platelets and white blood cells, so the higher PWR will provide better clinical outcomes. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2020,

title = { Histopathological spectrum of endometrial biopsies in a tertiary care hospital: a retrospective institutional study},

author = {Mehveen Rahim Khan and Abdul Wase and Nabila Afsar and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/histopathological-spectrum-of-endometrial-biopsies-in-a-tertiary-care-hospital--a-retrospective-institutional-study_December_2020_0777706621_4527162.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-12-01},

urldate = {2020-12-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {12},

pages = {37-39},

abstract = {Endometrial biopsies are obtained for a number of reasons that include abnormal uterine bleeding in certain age groups, incomplete abortions, or suspected neoplasia and the endometrium may be sampled prior to certain procedures to treat infertility to determine the phase of the cycle to guide further tests or treatments. The study is a retrospective cross-sectional study carried out in the Department of Pathology of Owaisi hospital and research centre , on specimens received over a one-year period. 200 Samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding received to the histopathology laboratory were analyzed. Patients were categorized into reproductive age groups (18-40 yrs), perimenopausal (41-50), and postmenopausal (>50yrs). Most common lesion is endometrial hyperplasia comprising 61% of total cases. The next common lesion is Endometrial polyp which accounts for 29% of total cases. 2 cases of Endometrial carcinoma were found which comprised of 1% of total cases. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nagma_2019,

title = { Mixed connective tissue disease highlighting diagnostic exigency and treatment woes},

author = {Sabahat Zamani Nagma and Nabila Afsar and Idrees Akhtar Afroze and Atiya Begum},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2468/1758},

doi = {10.21276/APALM.2468},

issn = {2349-6983},

year  = {2019},

date = {2019-10-01},

urldate = {2019-10-01},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {9},

pages = {C97-C100},

abstract = {Mixed connective tissue disease (MCTD) is a rare connective tissue disease characterized by manifestations that overlap symptoms typical of several other inflammatory diseases of connective tissue. A presence of anti-ribonucleoprotein antibodies (antiU1RNP) in high titer is a typical immunological finding. A 20 year old female complained of chilling and cyanosis of fingers on cold exposure since 5 years, with pain and numbness, hardening of skin of both hands, episodes of Raynaud’s phenomenon,gangrenous changes, self amputation of distal digit of middle finger. Systemic manifestations were also associated. A 15 year old female complained of thickening and tightening of skin of face and hands since 5 months, associated with joint pains, shortness of breath, dysphagia and photosensitivity of skin. Both cases were positive for Anti U1-RNP and Anti-SSA/Ro52 antibodies. Serology, radiology and histopathology were performed. MCTD may be difficult to define as definite classification criteria are not fulfilled. Young and pediatric patients with skin manifestations must be investigated to initiate early treatment and monitor renal parameters. Patient compliance and trust in treating physician is a key to early diagnosis and treatment. Treating physician must recognize symptoms and refer patients to higher centres. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afsar_2019,

title = {Young immunocompetent individual positive for histoplasma capsulatum on bronchoalveolar lavage fluid cytology},

author = {Nabila Afsar and Maseera Zareen and Idrees Akhtar Afroze and Atiya Begum},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2348/1690},

doi = {10.21276/APALM.2348},

issn = {2349-6983},

year  = {2019},

date = {2019-03-16},

urldate = {2019-03-16},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {3},

pages = {C37-C39},

abstract = {Primary pulmonary histoplasmosis is a lung disease caused by dimorphic fungus Histoplasma Capsulatum. Bronchoalveolar fluid cytology is routinely performed as an inexpensive test even in under equipped laboratories. A 26 year old female, presented with persistent cough, evening rise of temperature and generalised weakness since 3 months and streaky hemoptysis since 3 weeks. CT showed consolidation in 

lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal 

cultures and antigen testing. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Supriya_2018,

title = {Abnormal uterine bleeding: role of sonography and histopathology in endometrial study with emphasis on the organic causes},

author = {M. Supriya and Atiya Begum},

url = {https://www.ijpo.co.in/journal-article-file/6428},

doi = {10.18231/2394-6792.2018.0048},

issn = {2394-6784},

year  = {2018},

date = {2018-10-16},

urldate = {2018-10-16},

journal = {Indian Journal of Pathology and Oncology},

volume = {5},

issue = {2},

pages = {262-268},

abstract = {Introduction: Abnormal uterine bleeding (AUB) is the most common complaint in women of all age groups. The causes for abnormal bleeding needs to be evaluated before subjecting the patient to complicated surgical procedures. Transvaginal sonography is a simple outpatient procedure to identify suitable candidates for endometrial biopsy which provides an accurate diagnosis. Aims and Objectives: 1. To emphasize on the correlation of sonology and histopathological findings and to provide the cause of pathology for Abnormal Uterine Bleeding (AUB) in majority of cases. 2. To study the clinical data of the patients presenting with AUB and its histopathological spectrum. Materials and Methods: This was a prospective study conducted in the department of Pathology over a period of one year from January 2016 to December 2016. Endometrial biopsies of patients of all age groups presenting with a chief complaint of Abnormal uterine bleeding and abnormal USG findings were included in the study while inadequate biopsies and patients with genital infections, pregnancy–complications were excluded. The biopsies were processed as per the standard protocol. Histopathological examination was done and the diagnosis was given. Results were statistically analyzed. Results: A total of 87 cases were analyzed based on age, clinical presentation, parity, correlation of sonography-

histopathological findings was done and the results were found to have statistically significant p values.

Conclusion: A combination of sonography with histopathology provides an accurate diagnosis for AUB in most of the cases, specifically those with organic pathology. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Supriya_2017,

title = {Dowling Degos disease: a clinicopathological study},

author = {M. Supriya and Syeda Naushaba Masood and Atiya Begum},

url = {https://www.rfppl.co.in/view_abstract.php?jid=10&art_id=6328},

doi = {10.21088/ijprp.2278.148X.6417.48},

issn = {2278-148X},

year  = {2017},

date = {2017-12-01},

urldate = {2017-12-01},

journal = {Indian Journal of Pathology: Research and Practice},

volume = {6},

number = {2},

issue = {4},

pages = {1114-1118},

abstract = {Background: DowlingDegos Disease (DDD) is a rare genetic disease of the skin having an autosomal dominant inheritance. It is grouped under reticulated pigmented anomalies and manifests as symmetric, progressive, pigmented macules over flexures, scattered comedolike lesions and pitted acneiform scars. Histopathology is required for definitive diagnosis and to distinguish it from other reticulate pigmentary genodermatoses. Aims: 1. To show the existence of this rare disease in the local population. (2) To stress on the clinicopathological correlation for the definitive diagnosis of the disease. Materials & Methods: Punch biopsies of skin received by the Department of Pathology over a span of two years with Dowling Degos Disease as one of the differential diagnosis, were included in the study. The biopsies were processed as per standard protocol. Diagnosis was confirmed by the histopathological examination. Result: A total of six cases were included in the study, out of which four were histologically confirmed as DDD and one case had features overlapping with Reticulate Acropigmentation of Kitamura (RAPK). The study showed female preponderance. Four cases had family history. The clinical and histopathological findings of each case are discussed. Conclusion: Dowling Degos Disease may not be a rare entity. It should be considered as one of the differential diagnoses for pigmentary disorders. With combined clinical and histopathological evaluation, more cases may come into light in the future and DDD may not remain as a rare disorder.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}