Dr. Idrees Akthar Afroze
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- Dr. Idrees Akthar Afroze
Faculty Details
- Designation: Professor
- Department: Pathology
Identifiers
Social Media
Faculty Details
- Phone:
- Email:
Work Experience
- Assistant Professor from 2005-2010
- Associate Professor from 2010-2017
- Professor from 2017-2023
- Professor & HOD from 2023 till date
Education
M.B.B.S (1990-1995)
M.D. Pathology (1999-2000)
Masters Degree in Hospital Management(MDHM) -(2017-2019)
Post Graduation Diploma in Healthcare Quality Assurance(PGDHQA)-2019
Fellowships/Memberships
Member of Indian Medical Association(IMA)
Publication
2022
Tabassum, Asiya; Afroze, Idrees Akhtar; Begum, Sumayya
In: International Journal of Medical Science and Innovative Research, vol. 7, iss. 3, pp. 155-162, 2022, ISSN: 2458-868X.
@article{Tabassum_2022b,
title = {Covid-19 vs dengue-role of WBC counts in segregation of cases at an early stage with special reference to NLR as a diagnostic and prognostic factor},
author = {Asiya Tabassum and Idrees Akhtar Afroze and Sumayya Begum },
url = {https://www.ijmsir.com/asset/images/uploads/16560077756647.pdf},
issn = {2458-868X},
year = {2022},
date = {2022-05-31},
urldate = {2022-05-31},
journal = {International Journal of Medical Science and Innovative Research},
volume = {7},
issue = {3},
pages = {155-162},
abstract = {Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the
initial stages but have different clinical management which makes it challenging for the health care professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done
decreasing the mortality and for better outcome of these patients. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the
initial stages but have different clinical management which makes it challenging for the health care professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done
decreasing the mortality and for better outcome of these patients.
initial stages but have different clinical management which makes it challenging for the health care professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done
decreasing the mortality and for better outcome of these patients.
Shamshuddeen, T. S.; Tabassum, Asiya; Tazeen, Naushaba; Afroze, Idrees Akhtar
Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas Journal Article
In: International Journal of Health Sciences, vol. 6, iss. S3, pp. 6963-6971, 2022, ISSN: 2550-696X.
@article{Shamshuddeen_2022,
title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},
author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},
url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},
doi = {10.53730/ijhs.v6ns3.7623},
issn = {2550-696X},
year = {2022},
date = {2022-05-20},
urldate = {2022-05-20},
journal = {International Journal of Health Sciences},
volume = {6},
issue = {S3},
pages = {6963-6971},
publisher = {Universidad Tecnica de Manabi},
abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.
2021
Asfiya, Khanam; Mehdi, Syed Mohammed Ali; Afroze, Idrees Akhtar; Shaikh, Fawwad M.; Begum, Sumayya; Afsar, Nabila
Role of eosinophil count for early recognition and prognostication of Covid-19 Journal Article
In: International Journal of Medical Science and Innovative Research, vol. 6, iss. 4, pp. 224-232, 2021, ISSN: 2458-868X.
@article{Asfiya_2021,
title = {Role of eosinophil count for early recognition and prognostication of Covid-19},
author = {Khanam Asfiya and Syed Mohammed Ali Mehdi and Idrees Akhtar Afroze and Fawwad M. Shaikh and Sumayya Begum and Nabila Afsar},
url = {https://www.ijmsir.com/asset/images/uploads/16281658002972.pdf},
issn = {2458-868X},
year = {2021},
date = {2021-07-01},
urldate = {2021-07-01},
journal = {International Journal of Medical Science and Innovative Research},
volume = {6},
issue = {4},
pages = {224-232},
abstract = {Background: The Severe Respiratory Distress Syndrome caused by the COVID-19 virus has turned into a pandemic and has caused havoc worldwide and is still continuing to do so. In such times, there is a need for a diagnostic tool which eases the technique of detecting the disease and is also less time consuming. Thus an analogy was established between the Covid-19 positive RT-PCR cases and their blood eosinophil levels. Aims: To study the diagnostic and Prognostic significance of eosinophil counts in Covid-19 infections. Settings and Design: This study that was conducted in a tertiary health care centre was done by analysing the eosinophil counts of the patients and there by correlating them with the progression of the disease. Materials and Methods: 105 Patients who tested positive by RT-PCR for COVID-19 were enrolled for this study and their complete blood count report was obtained. Statistical Analysis: The data analysis was done in proportions and percentages. The statistical test of significance applied manually to the cross table was chi square test. Result: Based on the outcome it was noted that 70.50% cases were eosinopenic on admission. Also drop in eosinophil count(93.75% of the cases) or the absence of eosinophils on presentation correlated with poor prognosis. Conclusion: Eosinopenia can help in early detection of Covid-19 infection and the variation in the eosinophil count can help in gauging the prognosis and the outcome of the disease.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: The Severe Respiratory Distress Syndrome caused by the COVID-19 virus has turned into a pandemic and has caused havoc worldwide and is still continuing to do so. In such times, there is a need for a diagnostic tool which eases the technique of detecting the disease and is also less time consuming. Thus an analogy was established between the Covid-19 positive RT-PCR cases and their blood eosinophil levels. Aims: To study the diagnostic and Prognostic significance of eosinophil counts in Covid-19 infections. Settings and Design: This study that was conducted in a tertiary health care centre was done by analysing the eosinophil counts of the patients and there by correlating them with the progression of the disease. Materials and Methods: 105 Patients who tested positive by RT-PCR for COVID-19 were enrolled for this study and their complete blood count report was obtained. Statistical Analysis: The data analysis was done in proportions and percentages. The statistical test of significance applied manually to the cross table was chi square test. Result: Based on the outcome it was noted that 70.50% cases were eosinopenic on admission. Also drop in eosinophil count(93.75% of the cases) or the absence of eosinophils on presentation correlated with poor prognosis. Conclusion: Eosinopenia can help in early detection of Covid-19 infection and the variation in the eosinophil count can help in gauging the prognosis and the outcome of the disease.
Hussain, Syed Arshad; Afroze, Idrees Akhtar; Shamshuddeen, T. S.
Role of neutrophil/lymphocyte ratio as a prognostic marker of cerebrovascular accident Journal Article
In: International Journal of Scientific Research, vol. 10, iss. 5, pp. 76-77, 2021, ISSN: 2277-8179.
@article{Hussain_2021b,
title = {Role of neutrophil/lymphocyte ratio as a prognostic marker of cerebrovascular accident},
author = {Syed Arshad Hussain and Idrees Akhtar Afroze and T. S. Shamshuddeen},
url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_May_2021_6510266714_9307901.pdf},
doi = {10.36106/ijsr},
issn = {2277-8179},
year = {2021},
date = {2021-05-01},
urldate = {2021-05-01},
journal = {International Journal of Scientific Research},
volume = {10},
issue = {5},
pages = {76-77},
abstract = {NA},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
NA
2020
Khan, Mehveen Rahim; Afsar, Nabila; Afroze, Idrees Akhtar
Abdominal wall metastases of hepatocellular carcinoma-an unusual presentation Journal Article
In: International Journal of Scientific Research, vol. 9, iss. 11, pp. 52-53, 2020, ISSN: 2277-8179.
@article{Khan_2020b,
title = {Abdominal wall metastases of hepatocellular carcinoma-an unusual presentation},
author = {Mehveen Rahim Khan and Nabila Afsar and Idrees Akhtar Afroze},
url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/abdominal-wall-metastasis-of-hepatocellular-carcinomaan-unusual-presentation_November_2020_0418414166_1229394.pdf},
doi = {10.36106/ijsr},
issn = {2277-8179},
year = {2020},
date = {2020-11-01},
urldate = {2020-11-01},
journal = {International Journal of Scientific Research},
volume = {9},
issue = {11},
pages = {52-53},
abstract = {We report a case of 60 year old male with a swelling in the right iliac fossa which presented as desmoid tumour clinically and was later found to be metastasis from hepatocellular carcinoma.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We report a case of 60 year old male with a swelling in the right iliac fossa which presented as desmoid tumour clinically and was later found to be metastasis from hepatocellular carcinoma.
Siddiqui, Adiba; Tabassum, Nabiha; Afsar, Nabila; Afroze, Idrees Akhtar
Distribution of blood group type in diagnosed NS1Ag positive dengue patients in Hyderbad,Telangana State Journal Article
In: International Journal of Scientific Research, vol. 9, iss. 11, pp. 41-42, 2020, ISSN: 2277-8179.
@article{Siddiqui_2020,
title = {Distribution of blood group type in diagnosed NS1Ag positive dengue patients in Hyderbad,Telangana State},
author = {Adiba Siddiqui and Nabiha Tabassum and Nabila Afsar and Idrees Akhtar Afroze},
url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/distribution-of-blood-group-type-in-diagnosed-ns1-ag-positive-dengue-patients-in-hyderabad-telengana-state-india_November_2020_7061945912_4335125.pdf},
doi = {10.36106/ijsr},
issn = {2277-8179},
year = {2020},
date = {2020-11-01},
urldate = {2020-11-01},
journal = {International Journal of Scientific Research},
volume = {9},
issue = {11},
pages = {41-42},
abstract = {The aim of this study was to determine the distribution of blood group type in diagnosed NS1Ag positive dengue cases. The ABO phenotypes were identified by use of blood from patients with dengue virus infection prospectively, in newly diagnosed patients at a tertiary care hospital in south India. A total of 162 NS1Ag positive cases were collected with dengue illness. The greatest number (25%) of dengue cases were seen in the 11-20 year age group. Males were predominantly effected(58%). It was found that majority (45%) of cases belonged to blood group O.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The aim of this study was to determine the distribution of blood group type in diagnosed NS1Ag positive dengue cases. The ABO phenotypes were identified by use of blood from patients with dengue virus infection prospectively, in newly diagnosed patients at a tertiary care hospital in south India. A total of 162 NS1Ag positive cases were collected with dengue illness. The greatest number (25%) of dengue cases were seen in the 11-20 year age group. Males were predominantly effected(58%). It was found that majority (45%) of cases belonged to blood group O.
Afsar, Nabila; Sayeed, Hina; Shaikh, Fawwad M.; Afroze, Idrees Akhtar
Role of neutrophil lymphocyte ratio as a prognostic marker of dengue Journal Article
In: International Journal of Scientific Research, vol. 9, iss. 10, pp. 67-68, 2020, ISSN: 2277-8179.
@article{Afsar_2020,
title = {Role of neutrophil lymphocyte ratio as a prognostic marker of dengue},
author = {Nabila Afsar and Hina Sayeed and Fawwad M. Shaikh and Idrees Akhtar Afroze},
url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-dengue_October_2020_6114171606_8732160.pdf},
doi = {10.36106/ijsr},
issn = {2277-8179},
year = {2020},
date = {2020-10-01},
urldate = {2020-10-01},
journal = {International Journal of Scientific Research},
volume = {9},
issue = {10},
pages = {67-68},
abstract = {INTRODUCTION: Dengue is an important arthropod-borne viral infection in humans and is the second most important re-emerging tropical disease in the past 20 years all over the globe. Aim: To study neutrophil lymphocyte ratio in dengue cases and assess its role in relation with various demographic, serologic parameters and platelet count. MATERIAL AND METHODS: A retrospective study of 100 dengue cases admitted in a
tertiary care hospital in South India during the monsoon season of 2019 was carried out. Clinical data and CBC results were reviewed and analysed. The Chi Square test was used to compare categorical variables. RESULTS: Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. Neutrophil Lymphocyte
ratio(NLR) <2 strongly correlates with low platelets indicating severity of disease and reversal of NLR >2 correlates with improvement of disease. NLR <2 was more common in 0-20 years age group, younger the age lesser the Neutrophil Lymphocyte ratio and hence more severe the disease. CONCLUSION: Neutrophil Lymphocyte ratio acts as a prognostic indicator in dengue cases.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
INTRODUCTION: Dengue is an important arthropod-borne viral infection in humans and is the second most important re-emerging tropical disease in the past 20 years all over the globe. Aim: To study neutrophil lymphocyte ratio in dengue cases and assess its role in relation with various demographic, serologic parameters and platelet count. MATERIAL AND METHODS: A retrospective study of 100 dengue cases admitted in a
tertiary care hospital in South India during the monsoon season of 2019 was carried out. Clinical data and CBC results were reviewed and analysed. The Chi Square test was used to compare categorical variables. RESULTS: Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. Neutrophil Lymphocyte
ratio(NLR) <2 strongly correlates with low platelets indicating severity of disease and reversal of NLR >2 correlates with improvement of disease. NLR <2 was more common in 0-20 years age group, younger the age lesser the Neutrophil Lymphocyte ratio and hence more severe the disease. CONCLUSION: Neutrophil Lymphocyte ratio acts as a prognostic indicator in dengue cases.
tertiary care hospital in South India during the monsoon season of 2019 was carried out. Clinical data and CBC results were reviewed and analysed. The Chi Square test was used to compare categorical variables. RESULTS: Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. Neutrophil Lymphocyte
ratio(NLR) <2 strongly correlates with low platelets indicating severity of disease and reversal of NLR >2 correlates with improvement of disease. NLR <2 was more common in 0-20 years age group, younger the age lesser the Neutrophil Lymphocyte ratio and hence more severe the disease. CONCLUSION: Neutrophil Lymphocyte ratio acts as a prognostic indicator in dengue cases.
Afreen, Sobia; Afsar, Nabila; Afroze, Idrees Akhtar
Role of platelet parameters in acute coronary syndrome Journal Article
In: International Journal of Scientific Research, vol. 9, iss. 6, pp. 59-61, 2020, ISSN: 2277-8179.
@article{Afreen_2020,
title = {Role of platelet parameters in acute coronary syndrome},
author = {Sobia Afreen and Nabila Afsar and Idrees Akhtar Afroze},
url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-platelet-parameters-in-acute-coronary-syndrome_June_2020_1591092901_1816382.pdf},
doi = {10.36106/ijsr},
issn = {2277-8179},
year = {2020},
date = {2020-06-01},
urldate = {2020-06-01},
journal = {International Journal of Scientific Research},
volume = {9},
issue = {6},
pages = {59-61},
abstract = {ACS is a set of signs and symptoms due to rupture of a plaque which is a consequence of platelet rich coronary thrombus formation. Thrombus leads to partial or complete coronary artery occlusion which inturn leads to myocardial ischemia and various clinical manifestation ranging from UA to acute myocardial infarction. Conventional risk factors include smoking, diabetes mellitus, hyperlipidemia, obesity and stress which either act
singly or in combination increase the chances of developing coronary atherosclerosis.4 Platelet indices also vary in diseases like diabetes, hypertension, obesity, hyperlipidemia etc.,5 This study aims to study the role of platelet parameters in patients with acute coronary syndrome and those who are at higher risk in comparison with healthy individuals. Conclusion: These larger platelets can be easily identified during routine hematological analysis. For this purpose, we think that MPV measurement, in which is a non-invasive and easily available test, it may be an important tool predicting an impending acute coronary event and helping in early intervention to manage such patients. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
ACS is a set of signs and symptoms due to rupture of a plaque which is a consequence of platelet rich coronary thrombus formation. Thrombus leads to partial or complete coronary artery occlusion which inturn leads to myocardial ischemia and various clinical manifestation ranging from UA to acute myocardial infarction. Conventional risk factors include smoking, diabetes mellitus, hyperlipidemia, obesity and stress which either act
singly or in combination increase the chances of developing coronary atherosclerosis.4 Platelet indices also vary in diseases like diabetes, hypertension, obesity, hyperlipidemia etc.,5 This study aims to study the role of platelet parameters in patients with acute coronary syndrome and those who are at higher risk in comparison with healthy individuals. Conclusion: These larger platelets can be easily identified during routine hematological analysis. For this purpose, we think that MPV measurement, in which is a non-invasive and easily available test, it may be an important tool predicting an impending acute coronary event and helping in early intervention to manage such patients.
singly or in combination increase the chances of developing coronary atherosclerosis.4 Platelet indices also vary in diseases like diabetes, hypertension, obesity, hyperlipidemia etc.,5 This study aims to study the role of platelet parameters in patients with acute coronary syndrome and those who are at higher risk in comparison with healthy individuals. Conclusion: These larger platelets can be easily identified during routine hematological analysis. For this purpose, we think that MPV measurement, in which is a non-invasive and easily available test, it may be an important tool predicting an impending acute coronary event and helping in early intervention to manage such patients.
2019
Afsar, Nabila; Nagma, Sabahat Zamani; Afroze, Idrees Akhtar
Anemia: a diagnostic malady in management of dengue patients Journal Article
In: Annals of Pathology and Laboratory Medicine, vol. 6, iss. 12, pp. A647-A652, 2019, ISSN: 2349-6983.
@article{Afsar_2019b,
title = {Anemia: a diagnostic malady in management of dengue patients},
author = {Nabila Afsar and Sabahat Zamani Nagma and Idrees Akhtar Afroze},
url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2542/1793},
doi = {10.21276/APALM.2542},
issn = {2349-6983},
year = {2019},
date = {2019-12-28},
urldate = {2019-12-28},
journal = {Annals of Pathology and Laboratory Medicine},
volume = {6},
issue = {12},
pages = {A647-A652},
abstract = {Background: With the high prevalence of anemia and increasing incidence of dengue in developing countries like India, diagnosis of anemia in dengue patients needs to be stressed. There is higher hemoglobin and hematocrit as a result of plasma leakage in dengue; hence diagnosis and treatment of anemia may be missed.
Methods: A retrospective study was done on 138 dengue patients diagnosed in 2017, in a tertiary care teaching hospital in Hyderabad. The complete blood counts and blood picture data was retrieved and statistical analysis was performed using Microsoft Excel. Result: 60% of patients >5 yrs of age showed low hemoglobin while 93.3% showed hypochromia. In patients aged 5-11yrs and 12-14 yrs, 31.4% and 14.3% respectively had low hemoglobin, but hypochromia was noted in 48.6% and 57.1% .In non pregnant females, 68.4%
showed low hemoglobin while 55.3% showed hypochromia. In males, 25% showed low hemoglobin whereas 13.9% showed hypochromia. Wide variability in hemoglobin concentration of same patient was noted with coefficient of variation above 1% in 91.7% of cases. MCV and MCH had coefficient of variation more than 1.1% and 0.5% in 25% and 69.4% of cases respectively. Conclusion: Mean corpuscular volume is a stable parameter which can be used to assess the morphological status of the RBC even in a background of hemoconcentration where the hemoglobin is spuriously raised. The importance of inclusion of red cell indices especially mean corpuscular volume in complete blood counts reports is stressed.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: With the high prevalence of anemia and increasing incidence of dengue in developing countries like India, diagnosis of anemia in dengue patients needs to be stressed. There is higher hemoglobin and hematocrit as a result of plasma leakage in dengue; hence diagnosis and treatment of anemia may be missed.
Methods: A retrospective study was done on 138 dengue patients diagnosed in 2017, in a tertiary care teaching hospital in Hyderabad. The complete blood counts and blood picture data was retrieved and statistical analysis was performed using Microsoft Excel. Result: 60% of patients >5 yrs of age showed low hemoglobin while 93.3% showed hypochromia. In patients aged 5-11yrs and 12-14 yrs, 31.4% and 14.3% respectively had low hemoglobin, but hypochromia was noted in 48.6% and 57.1% .In non pregnant females, 68.4%
showed low hemoglobin while 55.3% showed hypochromia. In males, 25% showed low hemoglobin whereas 13.9% showed hypochromia. Wide variability in hemoglobin concentration of same patient was noted with coefficient of variation above 1% in 91.7% of cases. MCV and MCH had coefficient of variation more than 1.1% and 0.5% in 25% and 69.4% of cases respectively. Conclusion: Mean corpuscular volume is a stable parameter which can be used to assess the morphological status of the RBC even in a background of hemoconcentration where the hemoglobin is spuriously raised. The importance of inclusion of red cell indices especially mean corpuscular volume in complete blood counts reports is stressed.
Methods: A retrospective study was done on 138 dengue patients diagnosed in 2017, in a tertiary care teaching hospital in Hyderabad. The complete blood counts and blood picture data was retrieved and statistical analysis was performed using Microsoft Excel. Result: 60% of patients >5 yrs of age showed low hemoglobin while 93.3% showed hypochromia. In patients aged 5-11yrs and 12-14 yrs, 31.4% and 14.3% respectively had low hemoglobin, but hypochromia was noted in 48.6% and 57.1% .In non pregnant females, 68.4%
showed low hemoglobin while 55.3% showed hypochromia. In males, 25% showed low hemoglobin whereas 13.9% showed hypochromia. Wide variability in hemoglobin concentration of same patient was noted with coefficient of variation above 1% in 91.7% of cases. MCV and MCH had coefficient of variation more than 1.1% and 0.5% in 25% and 69.4% of cases respectively. Conclusion: Mean corpuscular volume is a stable parameter which can be used to assess the morphological status of the RBC even in a background of hemoconcentration where the hemoglobin is spuriously raised. The importance of inclusion of red cell indices especially mean corpuscular volume in complete blood counts reports is stressed.
Nagma, Sabahat Zamani; Afsar, Nabila; Afroze, Idrees Akhtar; Begum, Atiya
Mixed connective tissue disease highlighting diagnostic exigency and treatment woes Journal Article
In: Annals of Pathology and Laboratory Medicine, vol. 6, iss. 9, pp. C97-C100, 2019, ISSN: 2349-6983.
@article{Nagma_2019,
title = { Mixed connective tissue disease highlighting diagnostic exigency and treatment woes},
author = {Sabahat Zamani Nagma and Nabila Afsar and Idrees Akhtar Afroze and Atiya Begum},
url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2468/1758},
doi = {10.21276/APALM.2468},
issn = {2349-6983},
year = {2019},
date = {2019-10-01},
urldate = {2019-10-01},
journal = {Annals of Pathology and Laboratory Medicine},
volume = {6},
issue = {9},
pages = {C97-C100},
abstract = {Mixed connective tissue disease (MCTD) is a rare connective tissue disease characterized by manifestations that overlap symptoms typical of several other inflammatory diseases of connective tissue. A presence of anti-ribonucleoprotein antibodies (antiU1RNP) in high titer is a typical immunological finding. A 20 year old female complained of chilling and cyanosis of fingers on cold exposure since 5 years, with pain and numbness, hardening of skin of both hands, episodes of Raynaud’s phenomenon,gangrenous changes, self amputation of distal digit of middle finger. Systemic manifestations were also associated. A 15 year old female complained of thickening and tightening of skin of face and hands since 5 months, associated with joint pains, shortness of breath, dysphagia and photosensitivity of skin. Both cases were positive for Anti U1-RNP and Anti-SSA/Ro52 antibodies. Serology, radiology and histopathology were performed. MCTD may be difficult to define as definite classification criteria are not fulfilled. Young and pediatric patients with skin manifestations must be investigated to initiate early treatment and monitor renal parameters. Patient compliance and trust in treating physician is a key to early diagnosis and treatment. Treating physician must recognize symptoms and refer patients to higher centres. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mixed connective tissue disease (MCTD) is a rare connective tissue disease characterized by manifestations that overlap symptoms typical of several other inflammatory diseases of connective tissue. A presence of anti-ribonucleoprotein antibodies (antiU1RNP) in high titer is a typical immunological finding. A 20 year old female complained of chilling and cyanosis of fingers on cold exposure since 5 years, with pain and numbness, hardening of skin of both hands, episodes of Raynaud’s phenomenon,gangrenous changes, self amputation of distal digit of middle finger. Systemic manifestations were also associated. A 15 year old female complained of thickening and tightening of skin of face and hands since 5 months, associated with joint pains, shortness of breath, dysphagia and photosensitivity of skin. Both cases were positive for Anti U1-RNP and Anti-SSA/Ro52 antibodies. Serology, radiology and histopathology were performed. MCTD may be difficult to define as definite classification criteria are not fulfilled. Young and pediatric patients with skin manifestations must be investigated to initiate early treatment and monitor renal parameters. Patient compliance and trust in treating physician is a key to early diagnosis and treatment. Treating physician must recognize symptoms and refer patients to higher centres.
Afsar, Nabila; Zareen, Maseera; Afroze, Idrees Akhtar; Begum, Atiya
Young immunocompetent individual positive for histoplasma capsulatum on bronchoalveolar lavage fluid cytology Journal Article
In: Annals of Pathology and Laboratory Medicine, vol. 6, iss. 3, pp. C37-C39, 2019, ISSN: 2349-6983.
@article{Afsar_2019,
title = {Young immunocompetent individual positive for histoplasma capsulatum on bronchoalveolar lavage fluid cytology},
author = {Nabila Afsar and Maseera Zareen and Idrees Akhtar Afroze and Atiya Begum},
url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2348/1690},
doi = {10.21276/APALM.2348},
issn = {2349-6983},
year = {2019},
date = {2019-03-16},
urldate = {2019-03-16},
journal = {Annals of Pathology and Laboratory Medicine},
volume = {6},
issue = {3},
pages = {C37-C39},
abstract = {Primary pulmonary histoplasmosis is a lung disease caused by dimorphic fungus Histoplasma Capsulatum. Bronchoalveolar fluid cytology is routinely performed as an inexpensive test even in under equipped laboratories. A 26 year old female, presented with persistent cough, evening rise of temperature and generalised weakness since 3 months and streaky hemoptysis since 3 weeks. CT showed consolidation in
lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal
cultures and antigen testing. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Primary pulmonary histoplasmosis is a lung disease caused by dimorphic fungus Histoplasma Capsulatum. Bronchoalveolar fluid cytology is routinely performed as an inexpensive test even in under equipped laboratories. A 26 year old female, presented with persistent cough, evening rise of temperature and generalised weakness since 3 months and streaky hemoptysis since 3 weeks. CT showed consolidation in
lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal
cultures and antigen testing.
lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal
cultures and antigen testing.
Farooqui, Rafae; Afsar, Nabila; Afroze, Idrees Akhtar
Role and significance of hematological parameters in diabetes mellitus Journal Article
In: Annals of Pathology and Laboratory Medicine, vol. 6, iss. 3, pp. A158-A162, 2019, ISSN: 2349-6483.
@article{Farooqui_2019,
title = {Role and significance of hematological parameters in diabetes mellitus},
author = {Rafae Farooqui and Nabila Afsar and Idrees Akhtar Afroze},
url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2355/1687},
doi = {0.21276/APALM.2355},
issn = {2349-6483},
year = {2019},
date = {2019-03-16},
urldate = {2019-03-16},
journal = {Annals of Pathology and Laboratory Medicine},
volume = {6},
issue = {3},
pages = {A158-A162},
abstract = {Background: Diabetes mellitus is a global metabolic disorder characterized by persistent hyperglycemia and increased risk of microvascular and macrovascular complications. Consistent elevation of HbA1c can be associated with functional and structural changes in hemoglobin molecule, cytoplasmic viscosity and osmotic disturbances within red cell. These changes may be reflected in the red cell analytical parameters. Methods:
120 subjects were studied. 41 were non diabetic healthy subjects (Group1). 79 were known diabetic patients, divided into two groups: HbA1c <7(39 subjects) Group 2 and HbA1c >7(40 subjects) Group 3. Sample for glucose estimation and CBC were collected in vacutainers containing sodium Fluoride and K 2EDTA respectively. Glucose, HbA1c and CBC estimation was carried out by auto analyzers. Result: Mean RBC count of diabetics with HbA1c<7 was less when compared to non-diabetic individuals. Significant decrease was noted in the mean RBC count, Hb, HCT and MCV of diabetics with HbA1c>7 when compared to non diabetic individuals. There was significant decrease in mean Hb, HCT, MCV, MCH of diabetics with HbA1c >7 when compared to diabetics with HbA1c <7. Conclusion: The findings in the present study suggest that diabetic patients with poor control are more prone to develop anemia. This indicates a need for routine CBP examination for early detection and management of anemia in diabetic patients at the primary care setting to reduce associated morbidity due to lowered immunity associated with anemia and complications such as diabetic ketoacidosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Diabetes mellitus is a global metabolic disorder characterized by persistent hyperglycemia and increased risk of microvascular and macrovascular complications. Consistent elevation of HbA1c can be associated with functional and structural changes in hemoglobin molecule, cytoplasmic viscosity and osmotic disturbances within red cell. These changes may be reflected in the red cell analytical parameters. Methods:
120 subjects were studied. 41 were non diabetic healthy subjects (Group1). 79 were known diabetic patients, divided into two groups: HbA1c <7(39 subjects) Group 2 and HbA1c >7(40 subjects) Group 3. Sample for glucose estimation and CBC were collected in vacutainers containing sodium Fluoride and K 2EDTA respectively. Glucose, HbA1c and CBC estimation was carried out by auto analyzers. Result: Mean RBC count of diabetics with HbA1c<7 was less when compared to non-diabetic individuals. Significant decrease was noted in the mean RBC count, Hb, HCT and MCV of diabetics with HbA1c>7 when compared to non diabetic individuals. There was significant decrease in mean Hb, HCT, MCV, MCH of diabetics with HbA1c >7 when compared to diabetics with HbA1c <7. Conclusion: The findings in the present study suggest that diabetic patients with poor control are more prone to develop anemia. This indicates a need for routine CBP examination for early detection and management of anemia in diabetic patients at the primary care setting to reduce associated morbidity due to lowered immunity associated with anemia and complications such as diabetic ketoacidosis.
120 subjects were studied. 41 were non diabetic healthy subjects (Group1). 79 were known diabetic patients, divided into two groups: HbA1c <7(39 subjects) Group 2 and HbA1c >7(40 subjects) Group 3. Sample for glucose estimation and CBC were collected in vacutainers containing sodium Fluoride and K 2EDTA respectively. Glucose, HbA1c and CBC estimation was carried out by auto analyzers. Result: Mean RBC count of diabetics with HbA1c<7 was less when compared to non-diabetic individuals. Significant decrease was noted in the mean RBC count, Hb, HCT and MCV of diabetics with HbA1c>7 when compared to non diabetic individuals. There was significant decrease in mean Hb, HCT, MCV, MCH of diabetics with HbA1c >7 when compared to diabetics with HbA1c <7. Conclusion: The findings in the present study suggest that diabetic patients with poor control are more prone to develop anemia. This indicates a need for routine CBP examination for early detection and management of anemia in diabetic patients at the primary care setting to reduce associated morbidity due to lowered immunity associated with anemia and complications such as diabetic ketoacidosis.
2017
Afsar, Nabila; Afroze, Idrees Akhtar; Tahniath, Habeebunnisa; Abid, Zakia
Role of mean platelet volume as an adjunct in evaluation of acute inflammation Journal Article
In: Annals of Pathology and Laboratory Medicine, vol. 4, iss. 4, pp. A466-A469, 2017, ISSN: 2349-6483.
@article{Afsar_2017,
title = { Role of mean platelet volume as an adjunct in evaluation of acute inflammation},
author = {Nabila Afsar and Idrees Akhtar Afroze and Habeebunnisa Tahniath and Zakia Abid},
url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/apalm1486/pdf_416},
doi = {10.21276/APALM.1486},
issn = {2349-6483},
year = {2017},
date = {2017-09-01},
urldate = {2017-09-01},
journal = {Annals of Pathology and Laboratory Medicine},
volume = {4},
issue = {4},
pages = {A466-A469},
abstract = {Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker.Methods: A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis.Conclusion: MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker.Methods: A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis.Conclusion: MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis.
2015
Afroze, Idrees Akhtar; Firdous, Fakeha; Quadri, Syed Sibghatullah; Adil, Mohammed Abdul Majid
A case of ambiguous genitalia diagnosed in a young male presenting clinically with left sided obstructed inguinal hernia Journal Article
In: International Journal of Recent Trends in Science and Technology, vol. 16, iss. 2, pp. 398-400, 2015, ISSN: 2249-8109.
@article{Afroze_2015,
title = {A case of ambiguous genitalia diagnosed in a young male presenting clinically with left sided obstructed inguinal hernia},
author = {Idrees Akhtar Afroze and Fakeha Firdous and Syed Sibghatullah Quadri and Mohammed Abdul Majid Adil},
url = {https://www.statperson.com/Journal/ScienceAndTechnology/Article/Volume16Issue2/16_2_43.pdf},
issn = {2249-8109},
year = {2015},
date = {2015-09-11},
urldate = {2015-09-11},
journal = {International Journal of Recent Trends in Science and Technology},
volume = {16},
issue = {2},
pages = {398-400},
abstract = {Ambiguous genetalia is a disorder of sex development (DSD). It occurs when something goes wrong during pregnancy to interrupt or disturb the fetus developing sex organs. Presence or absence of male hormones control the development of sex organs. A disruption of steps that determine sex can result in a mismatch between external genitals and internal sex organs or the chromosomal sex (xx or xy). Other causes can be mutations in certain genes or chromosomal abnormalities like missing sex chromosome or an extra one. Ambiguous genitalia is usually not life threatening, but can create social problem for the child and family.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ambiguous genetalia is a disorder of sex development (DSD). It occurs when something goes wrong during pregnancy to interrupt or disturb the fetus developing sex organs. Presence or absence of male hormones control the development of sex organs. A disruption of steps that determine sex can result in a mismatch between external genitals and internal sex organs or the chromosomal sex (xx or xy). Other causes can be mutations in certain genes or chromosomal abnormalities like missing sex chromosome or an extra one. Ambiguous genitalia is usually not life threatening, but can create social problem for the child and family.