@article{Vuppala_2024,

title = {Clinico-demographic profile and outcome of acute pediatric hydrocarbon poisoning in South India},

author = {Anil Kumar Vuppala and Rama Krishna Nelakurthi and Shalini Akunuri and Ahlaam Arif and M. Aleemuddin Naveed},

url = {https://www.publichealthtoxicology.com/pdf-189940-111867?filename=Clinico_demographic.pdf},

doi = {10.18332/pht/189940},

issn = {2732-8929},

year  = {2024},

date = {2024-06-28},

urldate = {2024-06-28},

journal = {Public Health Toxicology},

volume = {4},

issue = {2},

pages = {1-6},

abstract = {Introduction: Acute hydrocarbon poisoning in children is an important cause of morbidity and mortality in developing countries. This study aimed to understand clinico-demographic profile and outcome of acute hydrocarbon poisoning in children belonging to low-middle economy families from South India. Methods:

A prospective observational study was conducted over 18 months from January 2022 to June 2023 in a private medical college from South India for children between 1 month and 18 years of age admitted with a history of acute hydrocarbon poisoning. Results: Out of 1568 admissions, 29 children had acute hydrocarbon poisoning. Median age was 2.6 years (range: 6 months-15year). The majority (58.6%) belonged to toddler age group. The male-to-female ratio was 1.6:1. Most (48.3%) cases were seen during summer. All poisonings were accidental and occurred via the ingestion route. Paint thinner (75.9%) and mosquito repellent (20.7%) were the most common agents implicated. Vomiting (69%), cough (24.1%), and respiratory distress (20.7%) were the predominant symptoms noted. Chest radiograph was abnormal in 10% of patients. Respiratory support was provided in 44% of patients. 70% of patients were discharged within 24 hours. There was no mortality. Conclusions: Acute hydrocarbon poisoning is a preventable cause of mortality and morbidity in children. The majority of cases occur in the toddler age group and are accidental. Most patients improve with simple conservative measures. Following unit protocols for the management avoids unnecessary investigations, and medications and promotes early discharge.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2023d,

title = {Morphometric study of human brain ventricles by magnetic resonance imaging in Indian population: a retrospective study},

author = {Zafar Sultana Abdul Saleem and Farah Bahmed and Syeda Sadia Sameera and Sravan Kumar Marupaka and Habib Khan Gulab Khan Pathan},

url = {https://journals.lww.com/jdyu/fulltext/2023/12020/morphometric_study_of_human_brain_ventricles_by.15.aspx},

doi = {10.4103/jdrntruhs.jdrntruhs_210_22},

issn = {5555-6666},

year  = {2023},

date = {2023-12-01},

urldate = {2023-12-01},

journal = {Journal of Dr. YSR University of Health Sciences},

volume = {12},

issue = {2},

pages = {171-177},

abstract = {Introduction: Ventricular parameters are used to study hydrocephalus, schizophrenia, tumors, trauma, Alzheimers disease, gender, aging and atrophy associated with many neurological diseases as stroke and dementia, to assess loss of brain parenchyma. Normal reference values of brain ventricles obtained by MRI are necessary to create baseline data for interpreting pathological changes, planning surgery and determining presence and progress of some neurological disorders. Materials and Method: This is a retrospective, cross sectional and non-interventional study. we have studied 100 brain MRI digital images. Following parameters have been studied frontal horn width [FHW], transverse internal diameter of skull[TIDS-F] at same level, frontal horn ratio[FHR], frontal horn length on both sides [FHLR & FHLL], total length of lateral ventricle on both sides [LVLR & LVLL], posterior horn width [PHW], transverse internal diameter of skull at same level [TIDS-P], fourth ventricle width [FVW] and fourth ventricle anteroposterior distance [FVAP]. SPSS. version. 21 was used for statistical analysis. Results: There were 54 females and 46 males between age 20 years to above 60 years. Frontal horn width, posterior horn width and total inner diameter of skull at frontal and posterior level has shown significant gender differences with P value as 0.0034,0.0004,0.00013 and 0.0004 respectively. Frontal horn ratio, total length of right and left lateral ventricles and total inner diameter of skull has shown significant increase with age. Conclusion: The normal reference values of ventricles obtained from MRI are necessary to form baseline data, for interpreting pathological changes and planning surgeries.volumetric measurements will provide more information than linear measurements.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nidha_Fatima_2023,

title = {A case report of Kocher Debre Semelaigne syndrome – congenital hypothyroidism with pseudomuscular hypertrophy},

author = {Nidha Fatima and Faraaz Adil and Habib Khan Gulab Khan Pathan},

url = {https://mansapublishers.com/index.php/ijch/article/view/3956/3281},

doi = {10.32677/ijch.v10i7.3956},

issn = {2349-6118},

year  = {2023},

date = {2023-07-01},

urldate = {2023-07-01},

journal = {Indian Journal of Child Health},

volume = {10},

issue = {7},

pages = {90-91},

publisher = {Mansa STM Publishers},

abstract = {Kocher Debre Semealaigne Syndrome (KDSS) is a rare condition with the manifestation of hypothyroidism associated with pseudomuscular hypertrophy. This syndrome is rare in countries with screening programs for hypothyroidism at birth. We are reporting a rare case of KDSS in which earlier diagnosis and treatment would result in the reversal of many symptoms. The main objective of presenting this case is to enlighten pediatricians about prompt diagnosis and timely management to prevent avoidable complications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nasreen_2023,

title = {Seroprevalence of HPV infection and its association with HPV vaccination in adolescent girls in suburbs of Hyderabad},

author = {Humera Nasreen and Habib Khan Gulab Khan Pathan and Sarfaraz Ahmed Manzoor Ahmed},

url = {https://healthcare-bulletin.co.uk/article?article_id=758&download=true},

doi = {10.5083/ejcm },

issn = {2042-4884},

year  = {2023},

date = {2023-06-16},

urldate = {2023-06-16},

journal = {European Journal of Cardiovascular Medicine},

volume = {13},

issue = {2},

pages = {1436-1439},

abstract = {Background: The prevalence of cervical cancer is increasing day by day. One of the best methods to prevent it is vaccination by HPV (Human Papilloma Virus) vaccine. Now a day’s more and more females are coming forward to take HPV vaccine. Sero-prevalence is one of the best methods to assess disease burden in the community Objectives: 1.  To study sero-prevalence of HPV in adolescent girls.  2. To study association of seroprevalence of HPV with HPV vaccination.  Method:  A community based cross sectional study was performed to assess the sero-prevalence of HPV at two private schools in suburban areas of Hyderabad, Telangana, in April 2022 to September 2022. Blood samples from 100 adolescent girls were collected & analysed for HPV specific antibodies by ELISA. Results:  The sero-prevalence for HPV in the study group was low. There was a statistically significant HPV sero-positivity in all girls receiving HPV (<0.05). An association of sero-prevalence with age was analysed. There was no statistically significant association between age & HPV antibodies (p>0.05 Conclusion:  The prevalence of HPV infection among adolescent girls is low and it is strongly associated with HPV vaccination.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arif_2023,

title = {Two cases of seizures due to lignocaine toxicity following elective circumcision},

author = {Ahlaam Arif and Mohammed Mujahid Ali and Shaik Mazahar Hussain and Habib Khan Gulab Khan Pathan and Shalini Akunuri},

url = {https://irispublishers.com/ann/pdf/ANN.MS.ID.000855.pdf},

doi = {10.33552/ANN.2023.15.000855},

issn = {2641-1911},

year  = {2023},

date = {2023-04-21},

urldate = {2023-04-21},

journal = {Archives in Neurology & Neuroscience},

volume = {15},

issue = {2},

pages = {1-2},

abstract = {Lignocaine is the most preferred local anesthetic worldwide; however, it is not without its side effects. Local anesthetic systemic toxicity is commonly reported as seizures, respiratory arrest, or adverse cardiac events like arrythmias. We report 2 cases of lignocaine toxicity presenting as generalized seizures and respiratory failure. Both required mechanical ventilation for variable duration, and both were eventually discharged, however, in stark contrasting state where one of them was completely normal and the other severely neuro-debilitated. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Muzammil_2022,

title = {SSPE with ocular manifestation “Eye as window to the brain"},

author = {Mohammed Muthiuddin Muzammil and Khuteja Fatima and Habib Khan Gulab Khan Pathan},

url = {https://irispublishers.com/ann/pdf/ANN.MS.ID.000821.pdf},

doi = {10.33552/ANN.2022.13.000821},

issn = {2641-1911},

year  = {2022},

date = {2022-12-14},

urldate = {2022-12-14},

journal = {Archives in Neurology & Neuroscience},

volume = {13},

issue = {5},

pages = {1-3},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2022e,

title = {Asymmetrical septal hypertrophy: a rare case of respiratory distress in an infant of a diabetic mother},

author = {Syed Adnan Ali and C. V. S. Lakshmi and Uppin Narayan Reddy and Hunaina Manfusa },

url = {https://saspublishers.com/media/articles/SJMCR_103_230-232_WjXuEIO.pdf},

doi = {10.36347/sjmcr.2022.v10i03.015},

issn = {2347-6559},

year  = {2022},

date = {2022-03-14},

urldate = {2022-03-14},

journal = {Scholars Journal of Medical Case Reports},

volume = {10},

issue = {3},

pages = {230-232},

publisher = {SASPR Edu International Pvt. Ltd},

abstract = {Introduction: Cardiomyopathy is a disease that affects the myocardium and causes mechanical or electric dysfunction. Hypertrophic cardiomyopathy comprises various cardiac components such as thickening of ventricular walls, hypertrophy of inter-ventricular septum thereby resulting in sub-aortic stenosis, systolic and/or diastolic dysfunction. This cardiac complication is a known but rare entity in infants of diabetic mothers wherein the clinical presentation ranges from being asymptomatic to respiratory distress to congestive cardiac failure. The incidence of Congenital Heart Disease in infants of Diabetic Mothers is 5% and the percentage of symptomatic HOCM babies is 12%. Case Report: We report a term neonate, born to a G2P2L2 mother with Gestational Diabetes Mellitus with poor glycemic control, presenting with respiratory distress manifesting as silent tachypnea at 24 hours of life, diagnosed as Asymmetrical Septal Hypertrophy on 2D-Echo, treated successfully with Propranolol and showed resolution of hypertrophy in follow-up echocardiography. Conclusion: Fetal hyperinsulinemia is responsible for the increase in synthesis and deposition of fat and glycogen in the myocardial cells which explains cardiac hypertrophy. Due to an increase in the thickness of the Interventricular Septum, there is Left Ventricular Hypertrophy and during systole, the Systolic Anterior Motion of the anterior leaflet (SAM) of the aortic valve is elongated. Therefore, due to this obstruction of the orifice by the aortic valve, there is a reversal of blood flow clinically manifesting as silent tachypnea. Symptomatic babies are treated with Oral Propranolol which acts by improving left ventricular outflow obstruction.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sreerambhatla_2022,

title = {Contribution of genetic variants of DNA repair genes XRCC1 and APE1 in pediatric patients with food and air born allergen asthma},

author = {Nandita Sreerambhatla and Uppin Narayan Reddy and Shaik Iqbal Ahmed and Nusrath Fathima and Aleem Ahmed Khan},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/contribution-of-genetic-variants-of-dna-repair-genes-xrcc1-and-ape1-in-pediatric-patients-with-food-and-air-born-allergen-asthma_February_2022_8241044964_1206692.pdf},

doi = {10.36106/ijar},

issn = {2249-555X},

year  = {2022},

date = {2022-02-28},

urldate = {2022-02-28},

journal = {Indian Journal of Applied Research},

volume = {12},

issue = {2},

pages = {45-47},

abstract = {INTRODUCTION: Allergic asthma in children occurs in response to an allergic trigger major. In the pathophysiology of asthma, genetic variations in many loci and genes play a crucial role. Genes of DNA repair pathways have been well characterized in association with clinical pathologies of different forms of allergic asthma with conicting outcomes. This study reports the role of single nucleotide polymorphisms (SNPs) in X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1)polymorphisms in pediatric patients with food and air born allergen asthma. METHODS: 125 pediatric asthma patients and age and gender matched 164 controls were enrolled. Blood samples were collected after conrming the food and air allergen related asthma. Genomic DNA was isolated from whole blood and genotyping was done for XRCC1 Arg399Gln and APE1 Asp148Glu using ARMS-PCR. RESULTS: The frequency of genotype Arg399Gln (heterozygous) of XRCC1 gene was signicantly higher in patients with allergic asthma than the controls (odds ratio [OR] 2.75; 95% condence interval [CI] 1.69 -4.47; p=0.006). 'A' allele of XRCC1 gene was found to be predominant in pediatric asthma group compared to controls. Similarly the genotype TG frequency of APE1 Asp148Glu showed statistically signicant change in allergic asthma patients compare to controls (OR 2.93; 95% CI 1.77-4.85; p<0.001). 'G' allele of APE1 gene was found predominantly in pediatric asthma group compared to controls. CONCLUSION: Polymorphisms in XRCC1 Arg399Gln and APE1 Asp148Glu signicantly increased the risk of allergic asthma in pediatric patients.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2021,

title = {A prospective study on etiological factors and clinical indicators in term and near term neonates admitted with hyperbilirubinemia in NICU in a tertiary care hospital in Hyderabad, India},

author = {Syed Adnan Ali and C. V. S. Lakshmi and Uppin Narayan Reddy and Farhana Nazneen},

url = {https://www.ijmpo.com/journal-article-file/14451},

doi = {10.18231/j.ijmpo.2021.011},

issn = {2581-4699},

year  = {2021},

date = {2021-08-03},

urldate = {2021-08-03},

journal = {IP International Journal of Medical Paediatrics and Oncology},

volume = {7},

issue = {2},

pages = {51-56},

abstract = {Objectives: 1. To study the etiology and risk factors of neonatal hyperbilirubinemia in term and near-term

infants. 2. To study the clinical course of these infants during NICU stay. Materials and Methods: The present study was conducted at NICU, Department of Pediatrics, Princess Esra hospital, Deccan Medical College, Hyderabad, India, from October 2019 to October 2020. Term and late preterm infants admitted in NICU with Serum Bilirubin levels more than 12mg/dl were included in the study. The risk factors, etiology and clinical profile of these infants during NICU stay were studied. Results: 210 neonates were admitted in NICU with hyperbilirubinemia (Serum Bilirubin >12mg/dl) during the study period, out of which 118 were male (56.20%) and 92 were female (43.80%). Neonates were further distributed based on gestational age, in which 46 (21.90%) were late pre-terms i.e. between 34-37 weeks and 164 neonates (78.10%) were full term i.e. greater than 37 weeks. The neonates were also classified based on their birth weight, with neonates between 2500-3000 grams having the highest incidence (46.19%). Lastly, the etiological and risk factors were assessed and quantified, with physiological jaundice occurring as the major cause and late prematurity as the most common risk factor associated with neonatal hyperbilirubinemia. The average duration of phototherapy was 2.50 days and 3 babies required Double Volume Exchange Transfusion (DVET) for significant hyperbilirubinemia. None of the babies requiring DVET had clinical features of Bilirubin Induced Neurological Dysfunction (BIND) during NICU stay.

Conclusion: 1. Most common cause of neonatal hyperbilirubinemia was found to be Physiological followed by Septicemia and Idiopathic etiologies. Blood group incompatibilities were less common causes. 2. Phototherapy is a cheap and effective way to reduce bilirubin levels in neonatal jaundice. 3. Exchange transfusion is a safe procedure and should be considered when indicated, to decrease the incidence of BIND. All cases requiring DVET were due to blood group incompatibility. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khurram_2021,

title = {Urinary ascites in a neonate with posterior urethral valve},

author = {Mir Sumsam Ali Khurram and C. V. S. Lakshmi and Farhana Nazneen and Mohammed Uzair Khan},

url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/4201/2731},

doi = {10.18203/2349-3291.ijcp20212062},

issn = {2349-3283},

year  = {2021},

date = {2021-05-25},

urldate = {2021-05-25},

journal = {International Journal of Contemporary Pediatrics},

volume = {8},

issue = {6},

pages = {1125-1127},

abstract = {Urinary ascites in a newborn is an extremely rare condition, most commonly due to posterior urethral valves, due to transmission of high intravesical pressure to calyceal fornices, and subsequent urinary ascites either by calyceal perforation or filtration through walls of urinary tract and their rupture. We describe a newborn male baby, who presented with huge abdominal distension at birth, and diagnosed as urinary ascites on paracentesis. Baby was asphyxiated and required resuscitation at birth, and ventilatory support for 4 days in v/o significant abdominal distension. Micturating cystourethrogram (MCUG)and magnetic resonance imaging (MRI)showed posterior urethral valves. Baby also had a left sided urinoma and grade 4 vesicoureteral reflux (VUR)on MCUG. Post paracentesis and drainage of 400ml of ascetic fluid, and urinary catheterization, baby had significant improvement of deranged renal parameters, and diuresis, and could be weaned from ventilation. In v/o inability to negotiate a urethroscope, a vesicostomy was done for urinary drainage and fulguration of valves planned on follow-up.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ahmed_2021b,

title = {A study on etiology and clinical profile of respiratory distress among neonates received in NICU at a tertiary care centre in Hyderabad},

author = {Mohammad Kamil Ahmed and C. V. S. Lakshmi and Uppin Narayan Reddy},

url = {https://www.ijmrhs.com/medical-research/a-study-on-etiology-and-clinical-pr-ofile-of-respiratory-distress-among-neonates-received-in-nicu-at-a-tertiary-care-cen.pdf},

issn = {2319-5886},

year  = {2021},

date = {2021-04-01},

urldate = {2021-04-01},

journal = {International Journal of Medical Research & Health Sciences},

volume = {10},

issue = {4},

pages = {37-45},

abstract = {Background: Respiratory distress is the most frequent cause of admission in neonatal intensive care in both term and preterm infants. The clinical presentation of respiratory distress can vary from mild to severe respiratory distress requiring mechanical ventilation, and also depends on the respiratory support received before referral to a higher center. The etiology for respiratory distress depends on fetal, maternal, and environmental risk factors, and also on gestational age and birth weight. Objectives: This study was performed to assess and analyze the risk factors, etiology, clinical profile, morbidity, and mortality of neonates admitted with respiratory distress in NICU. Methods: This was a prospective study was done on 292 neonates admitted to Neonatal Intensive Care Unit (NICU) with respiratory distress. General information, socioeconomic status, detailed perinatal history, and clinical examination were documented. Results: 292 neonates admitted with respiratory distress were included in the study. Around 151 (51.7%) babies were born prematurely. The mode of delivery was LSCS in 254 (87.16%) neonates. The most important risk factors were delivery by Cesarian section and maternal infection (49%). Transient tachypnea of the newborn (45.2%), Congenital pneumonia (22.2%), and Late-onset sepsis (10.9%) were the most common causes of respiratory distress. 32.1% of these infants required respiratory support in the form of invasive and non-invasive ventilation. Only 3 infants (1.03%) of infants expired during the study period, due to severe RDS and late referral to the hospital. Conclusion: The most important risk factors for respiratory distress are delivery by Cesarian section and maternal infection. Early referral and early respiratory support help in better outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2020,

title = {A rare case of hydranencephaly: A case report},

author = {Zafar Sultana Abdul Saleem and Vanacharala Anantha Kumari and Habib Khan Gulab Khan Pathan},

url = {https://www.ijmhr.org/IntJAnatRes/IJAR.2020.152},

doi = {10.16965/ijar.2020.152},

issn = {2321-4281},

year  = {2020},

date = {2020-08-10},

urldate = {2020-08-10},

journal = {International Journal of Anatomy and Research},

volume = {8},

issue = {3},

pages = {7644-7648},

publisher = {IMED Research Publications},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Awasthi_2020,

title = {Micronutrient-fortified infant cereal improves Hb status and reduces iron-deficiency anaemia in Indian infants: an effectiveness study},

author = {Shally Awasthi and Uppin Narayan Reddy and Monjori Mitra and Shweta Singh and Sanjeev Ganguly and Ivana Jankovic and Dominik Grathwohl and Colin I. Cercamondi and Apurba Ghosh},

url = {https://www.cambridge.org/core/services/aop-cambridge-core/content/view/54F0C227B9B2ADD0A752D3BF06B367AB/S0007114519003386a.pdf/micronutrient-fortified-infant-cereal-improves-hb-status-and-reduces-iron-deficiency-anaemia-in-indian-infants-an-effectiveness-study.pdf},

doi = {10.1017/s0007114519003386},

issn = {0007-1145},

year  = {2020},

date = {2020-01-03},

urldate = {2020-01-01},

journal = {British Journal of Nutrition},

volume = {123},

issue = {7},

pages = {780-791},

publisher = {Cambridge University Press (CUP)},

abstract = {Anaemia affects approximately 69 % of Indian children aged 6–12 months, with Fe deficiency (ID) being a common cause. The effectiveness of micronutrient-fortified infant cereal in improving Fe status and neurodevelopment was evaluated in non-anaemic and mildly anaemic Indian infants. An intervention group (IC) enrolled at age 6 months consumed 50 g/d of rice-based cereal providing 3·75 mg Fe/d as ferrous fumarate for 6 months (n 80) and was compared with a matched static cross-sectional control group (CG) without intervention enrolled at age 12 months (n 80). Mean Hb was higher in IC (118·1 (sd 10·2) g/l) v. CG (109·5 (sd 16·4) g/l) at age 12 months (adjusted mean difference: 9·7 g/l; 95 % CI 5·1, 14·3; P < 0·001), while geometric mean serum ferritin tended to be higher (27·0 (–1 sd 13·4, +1 sd 54·4) v. 20·3 (–1 sd 7·5, +1 sd 55·0) ng/ml); P = 0·085) and soluble transferrin receptor was lower (1·70 (–1 sd 1·19, +1 sd 2·43) v. 2·07 (–1 sd 1·29, +1 sd 3·33) mg/l; P = 0·014). Anaemia (23 v. 45 %; P = 0·007) and ID (17 v. 40 %; P = 0·003) were lower in IC v. CG. Bayley Scales of Infant and Toddler Development Third Edition scores for language (P = 0·003), motor development (P = 0·018), social-emotional (P = 0·004) and adaptive behaviour (P < 0·001), but not cognitive development (P = 0·980), were higher in IC v. CG. No significant difference in anthropometric Z-scores was observed between the groups. Consuming a micronutrient-fortified infant cereal daily for 6 months during complementary feeding promoted better Fe status while reducing the risk for anaemia and ID and was associated with superior neurodevelopmental scores.},

key = {pmid31896356},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Akram_2019,

title = {Comparison of biomarkers of neonatal sepsis: procalcitonin and c-reactive protein},

author = {Angadi Wasim Akram and Altaf Naseem},

url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/479/949},

doi = {10.17511/ijpr.2019.i03.06 },

issn = {2349-3267},

year  = {2019},

date = {2019-03-31},

urldate = {2019-03-31},

journal = {Pediatric Review: International Journal of Pediatric Research},

volume = {6},

issue = {3},

pages = {134-143},

abstract = {Background: Procalcitonin in neonatal sepsis (NS) has high sensitivity compared to C-reactive protein (CRP), but its specificity is not yet clearly defined. Objectives: Evaluation of Procalcitonin as an early marker, assessing its diagnostic utility in early-onset NS was the primary and comparing the levels of Procalcitonin with CRP was secondary objective. Method: In this observational, prospective study, neonates meeting the selection criteria were included and grouped into three, according to clinical symptoms of sepsis and blood culture. Results: Blood samples from 75 babies (male = 61.0%) were analysed; 63.0% and 37.0% were of gestational age (GA) ≥ 37 and < 37 and weeks, respectively. Birth-weight< 2.5 kg and >2.5 Kg was noted in 52.0% and 48.0%, respectively. Meconium stained liquor (n=34), premature rupture of membranes (n=19) and prolonged labour/instrumental delivery (n=13) were major maternal risk factors.General (45.33%), respiratory (25.33%), gastrointestinal (17.33%), cardiovascular (6.66%)symptoms were common presentation; forty one (55.0%) were negative for procalcitonin and 34 (45.0%) were positive; 61 (81.0%) tested negative for CRP, only 14 (19.0%) were positive with levels >10mg/mL. Procalcitonin positivity was statistically significant (<0.05) for males, term babies and with normal birth weight favouring procalcitonin. of seven positive blood culture, coagulase positive staphylococci (n= 03), Klebsiella(n= 02), E. coli (n=01), Pseudomonas (n=01) were isolated. On correlation with blood culture, Procalcitonin showed better sensitivity and negative predictive value. Conclusion: Procalcitoninis a better early marker than CRP in early onset NS. It hasbetter positivity for male, term and normal birth weight babies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Prasad_2018,

title = {Down‘s syndrome‑ an independent risk factor of outcomes in isolated congenital duodenal atresia},

author = {G. Raghavendra Prasad and C. V. S. Lakshmi},

url = {https://www.jneonatalsurg.com/ojs/index.php/jns/article/view/440/pdf},

doi = {10.21699/jns.v7i3.787},

issn = {2226-0439},

year  = {2018},

date = {2018-07-24},

urldate = {2018-07-24},

journal = {Journal of Neonatal Surgery },

volume = {7},

issue = {3},

pages = {32-35},

abstract = {Introduction: There is no consensus in the available literature whether the coexistence of Down’s syndrome has adverse effect on the outcomes of neonates born with congenital duodenal atresia. Materials and Methods: A total of 29 neonates with congenital duodenal atresia were retrospectively studied for demographic details, sepsis parameters at admission, management, morbidity, and mortality. The neonates who were premature. Results: The sepsis parameters such as total leukocyte counts, erythrocyte sedimentation rate, serum procalcitonin levels, and serum C‑reactive protein levels were significantly increased, and the platelets were significantly decreased at admission in Group B subjects, as compared to Group A subjects. There were no complications noted in Group A, while Group B had significant morbidity. The neonates with congenital duodenal atresia with Down’s syndrome had 3.27 times more relative risk of mortality than those without Down’s syndrome. Down’s syndrome appears to be an independent risk factor for mortality in isolated congenital duodenal atresia with attributable risk of 37.8%. Conclusion: The presence of Down’s syndrome is a significant independent adverse risk factor of outcomes in isolated congenital duodenal atresia.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2017,

title = {Incidence of acute renal failure in birth asphyxia and its correlation with hypoxic ischemic encephalopathy (HIE)},

author = {B. Sugunakar Reddy and Uppin Narayan Reddy and Jakkampudi Nagasravani and Mohd. Nasir Mohiuddin},

url = {https://www.ijmrhs.com/medical-research/incidence-of-acute-renal-failure-in-birth-asphyxia-and-its-correlation-with-hypoxic-ischemic-encephalopathy-hie.pdf},

issn = {2319-5886},

year  = {2017},

date = {2017-04-01},

urldate = {2017-04-01},

journal = {International Journal of Medical Research & Health Sciences},

volume = {6},

issue = {4},

pages = {80-91},

abstract = {Introduction: Perinatal asphyxia is an essential reason for neonatal mortality and neurological morbidity. The

general rate of this condition is assessed to be between 1 to 10 for every 1000 live births and is affected by the

birth weight and gestational age of the infant furthermore by the neighbourhood accessibility of therapeutic assets. Methods: The underlying administration of every single such neonate comprised of putting the child under a servo-controlled radiant warmer and nursing them in the thermo-neutral range of temperature. About 41 cases accomplished for early identification of confusions and difficulties and their convenient administration. Following 72 h of birth and before 96 h of birth in the wake of getting educated composed assent from the guardians, under aseptic safety measures 3 ml blood was drawn and was assessed for blood urea (Berthelot strategy), serum creatinine (Jaffe’s test), serum electrolytes (Calorimetric technique) and urine yield was observed by applying plastic accumulation pack (minicom) and clinical state of the child was checked. Results: A sum of 1285 neonates were conceded in NICU for different issues, among them an aggregate of 90 neonates were conceded for perinatal asphyxia. A sum of 75 cases and 50 controls were chosen. The accompanying tables and figures represent the outcomes in subtle element. The outcomes got were examine blood urea and serum creatinine levels were essentially lifted in cases with renal disappointment, when contrasted with controls (P=0.001). Nevertheless, there was no distinction in electrolyte levels in both the gatherings. Conclusion: The most common perinatal danger component was MSAF (40%). In our study the commonest type of ARF in every one of the three phases of HIE was non-oliguric sort. The frequency of inherent renal disappointment in our study was 9.4%. Checking of blood urea, serum creatinine and urine yield helps in the early finding and administration of renal disappointment. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mirza_2017,

title = {A study to evaluate the role of intravenous immunoglobulin (IVIG) as an adjuvant in the management of neonatal sepsis in preterm babies},

author = {Awais Mirza and Uppin Narayan Reddy and Altaf Naseem and Sumsam Ali Khurram},

url = {https://www.ijmrhs.com/medical-research/a-study-to-evaluate-the-role-of-intravenous-immunoglobulin-ivig-as-an-adjuvant-in-the-management-of-neonatal-sepsis-in-p.pdf},

issn = {2319-5886},

year  = {2017},

date = {2017-03-01},

urldate = {2017-03-01},

journal = {International Journal of Medical Research & Health Sciences},

volume = {6},

issue = {3},

pages = {107-113},

abstract = {Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune deficient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at full term. Furthermore, exceptionally preterm newborn children have lessened supplement components, polymorphonuclear chemotaxis and are obligated to debilitate their capacity pools. Aims and Objectives: This planned study has been attempted with the accompanying targets, to concentrate on the administration of IVIG in addition with antibiotics to improves the therapeutic consequence of sepsis in preterm neonates. Materials and Methods: Sixty preterm neonates with sepsis were randomly assigned into study and control groups at a tertiary level neonatal intensive care unit, Princess Esra Hospital and Owaisi Hospital & Research Centre, Deccan College of Medical Sciences, Hyderabad, Telangana, India. Study-group was given IVIG in addition to standard treatment. Results: Total 60 patients were enrolled, 30 in study and 30 in control group. There were no gender differences (male 50%, female 50%) of neonates enrolled, which is also evident in the study (males 47.7%, females 52.3%) and control group (males 52.3%, females 47.7%). Conclusion: Low levels of immunity in preterm neonates results in increased morbidity and mortality in severe infection. Use of IVIG along with the antibiotics and other supportive therapy can improve the outcome. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naseem_2016,

title = {A study to evaluate the knowledge, attitude and practices of exclusive breast feeding among primi mothers of healthy term neonates in a tertiary care hospitals and predictors of failures of establishment of exclusive breast feeding in first six months},

author = {Altaf Naseem and Naila Mazher},

url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/25/23},

doi = {10.18203/2349-3291.ijcp20161589},

issn = {2349-3283},

year  = {2016},

date = {2016-12-21},

urldate = {2016-12-21},

journal = {International Journal of Contemporary Pediatrics},

volume = {3},

issue = {3},

pages = {810-814},

abstract = {Background: In India about 2.4 million children die each year of which two thirds are associated with infant feeding practices which are in appropriate. Thirteen percent reduction in infant mortality rate  has been estimated with breast feeding. Methods: This study is a cross-sectional questionnaire based study done in the setting of pediatric outpatient department at Owaisi hospital and research center Hyderabad. It was carried out over a duration of two years from 2013 to 2015. Results: Majority of mothers received antenatal counselling regarding benefits and management of breast feeding. Conclusions: Majority of the mothers had good knowledge;attitude and practices are still prevalent in the community which needs to be addressed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naseem_2016b,

title = {Comprehensive study of health problems in school children of Hyderabad, India},

author = {Altaf Naseem and Nayantara G. Rao},

url = {https://www.ijpediatrics.com/index.php/ijcp/article/view/23/21},

doi = {10.18203/2349-3291.ijcp20161470},

issn = {2349-3283},

year  = {2016},

date = {2016-12-21},

urldate = {2016-12-21},

journal = {International Journal of Contemporary Pediatrics},

volume = {3},

issue = {3},

pages = {801-805},

abstract = {Background: It is estimated that over one-fifth of our population comprises of children aged 5-14 years and only 80% of these children are enrolled in schools. A child spends most of the time in school and it is considered an ideal place for learning and growing up of a child. In India due to poverty and prevailing socio-cultural milieu a substantial number of school children suffer from various diseases which can be prevented if diagnosed and treated early. We conducted this study to evaluate the health and the nutritional status of school children and comparison was drawn between the rural and urban school children. Methods: This  is  a  cross sectional prospective study where a total of 500 school children from rural and urban government schools were thoroughly assessed by a detailed clinical examination including anthropometry. Results: It was observed that more than half of the children from both rural (56%) and urban (58%) schools were under nourished. The BCG vaccination coverage was better in urban school children (86.5%), with an overall coverage of 80%. Various other problems were more prevalent in rural school children except respiratory diseases which were observed to be more prevalent in urban school children (7.2%). Conclusions: It was learnt that the morbidity of school age children from the community’s perspective is entirely different from morbidity from health care professional’s perspective. Therefore, educating the community will go a long way in improving the quality of life.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khurram_2016,

title = {A study of evaluation of iron deficiency as a risk factor for febrile seizures},

author = {Mir Sumsam Ali Khurram and Uppin Narayan Reddy},

url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/200/397},

doi = {10.17511/ijpr.2016.11.11},

issn = {2349-3267},

year  = {2016},

date = {2016-11-30},

urldate = {2016-11-30},

journal = {Pediatric Review:International Journal Pediatric Research},

volume = {3},

issue = {11},

pages = {826-830},

abstract = {Objective: To estimate the incidence of seizure of iron deficiency anemia in febrile seizure. To determine the clinical correlates of children with febrile seizures. Methods: In this case, control study was conducted among 126 children of age group between 6 months and 5 years during April 2015 to April 2016. The control case groups were matched based on the family history of febrile seizure, age, sex, and temperature. Blood samples were collected. Measured quantities of serum feritin, hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin were compared. Result: 36 children (28.5%) in the febrile Seizure group have positive family history when compared to none among controls. Serum ferritin level in febrile seizure group is found to have 14.5+/-10.6 ng/ml, where as in controls it is 34.9+/-23.3 ng/ml .The mean hemoglobin was 9.8+/-1.2 gm/dl whereas in controls, it was 11.3+/-1.1gm/dl. The mean corpuscular volume is 76+/-8.5fl, whereas in control it is 79.5+/-7.5fl, which was statistically significant. The mean corpuscular hemoglobin was 27.7+/-3.1pg and for control it was 28.7/3.6 pg. Conclusion: Serum ferritin, Hb% and MCV were found to be significant on the lower side in children with febrile seizure when compared to the children who did not have febrile seizure.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Chacham_2016,

title = {Neonatal outcomes Rh-negative pregnancies in a tertiary level neonatal intensive care unit: a prospective study},

author = {Swathi Chacham and Diggireddy Shilpa Reddy and Uppin Narayan Reddy and Waseem Khan and Sreerambhatla Nandita and Soumya Anumula and Jakkampudi Nagasravani and Faraaz Adil},

url = {https://brieflands.com/articles/jcp-19862.pdf},

doi = {10.17795/compreped-36573},

issn = {2251-8150},

year  = {2016},

date = {2016-07-24},

urldate = {2016-07-24},

journal = {Journal of Comprehensive Pediatrics},

volume = {7},

issue = {3},

pages = {e36573},

abstract = {Background: Rhesus incompatibility is a preventable cause for severe neonatal hyperbilirubinemia, hydrops fetalis and still births. The prevalence of the Rh-negative blood group among Indian woman varies from 2% - 10%. Despite declining the incidence of Rhesus incompatibility, due to availability of anti-D immunoglobulin, and improved antenatal care of the Rh-negative pregnant woman, it still accounts for a significant proportion of neonatal hyperbilirubinemia and neuro-morbidity. The prevalence of Rh-negative women having Rh-positive neonates is 60%. Objectives: This study aimed to estimate the incidence of Rh iso-immunization and evaluate the outcomes of Rh iso-immunized neonates. Methods: This prospective observational study was conducted in a tertiary level neonatal intensive care unit, Princess Esra hospital, Deccan college of medical sciences, Hyderabad, Telangana, India. Consecutive intramural and extramural neonates admitted to neonatal intensive care unit with the Rh-negative mother’s blood group and hyperbilirubinemia were enrolled. Neonates born to Rh+ve mothers were excluded. Neonatal gestational age, birth weight, age at admission, duration of phototherapy, duration of hospitalization, neonatal examination and investigations were recorded in a predesigned, pretested performa. Results: A total of 90 neonates were born to Rh-negative mothers, of which 70% (63) had the Rh-positive blood group and 30% had the Rh-negative blood group. Of these 63 neonates, 48 (76.2%) had hyperbilirubinemia and 43 neonates (68.3%) had significant hyperbilirubinemia (total serum bilirubin > 15mg/dL). Among them, 2%, 75% and 23% were born to primi, multi and grandmutli, respectively. Also, 14.5% of the neonates were large for dates (LFD), 75% appropriate for dates (AFD) and 10.5% were small for dates (SFD). Premature and SFD neonates had higher incidence of hyperbilirubinemia. Significantly higher incidence of jaundice occurred within 72 hours of life. The mean serum bilirubin level among neonates with significant hyperbilirubinemia was 17.98 ± 1.76 (95% CI:17.43 - 18.52) while that of neonates without significant hyperbilirubinemia was 13.1 ± 0.53 (95% CI:12.47 - 13.77) with statistical significance (P < 0.0001). Maternal multiparity, direct coombs test (DCT) positivity, and abnormal neurosonogram (NSG) were important accompaniments of high serum bilirubin levels. Conclusions: Incidence of Rh-positive phenotype in neonates born to Rh-negative mothers is 70%. Incidence of hyperbilirubinemia among them is 76.2% and that of significant hyperbilirubinemia was 68.3%. The incidence of DCT positivity was 20.9%. Maternal multiparity, positive DCT and abnormal NSG were important associates of high serum bilirubin levels.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naseem_2016c,

title = {Accidental poisoning its magnitude and implications in children},

author = {Altaf Naseem and Mir Sumsam Ali Khurram and Sana Salim Khan and Nizar Lalani},

url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/127/250},

doi = {1 0.17511/ijpr.2016.i06.06},

issn = {2349-3267},

year  = {2016},

date = {2016-06-30},

urldate = {2016-06-30},

journal = {Pediatric Review: International Journal of Pediatric Research         },

volume = {3},

issue = {6},

pages = {400-409},

abstract = {Background: Paucity of data due to under reporting of accidental poisoning (AP) poses obstacle in assessing the trend, incidence, and mortality in pediatric population. Objective: Estimating the magnitude and assessing the pattern of AP in children was the primary objective. Describing the affected age group, common agents and assessment of  clinical features were the secondary objectives. Materials & Methods: Children aged 1month- 12years with history of AP were included; those with allergic reactions to plant products, food and idiosyncratic reactions to drugs were excluded. Result: 101 children accounted for 1.7% of total pediatric admission. Accidental ingestion of poisons (90.09%) and poisoning due to insect and snake bites (9.90%) were reported. Males (n=62) outnumbered females. Patients from urban area (68.2%), children aged 1-3 years (56.43%) were affected the most. All incidents were unintentional and occured in the home surroundings. April (n=21), March (n=20) recorded higher number followed by December (n=14). Hydrocarbon poisoning (43.56%) was most common followed by poisoning due to medicaments (18.8 %,), chemicals (12.87%), and food poisoning (9.90%).  Insect bites & stings were seen in 9.90%  Supportive treatment was given to 49.5%, further gastric absorption prevented in 24.45 % and specific antidote to 7.9% patients. Three patients died due to scorpion bite, Phenytoin and kerosene ingestion. Conclusion: AP is a preventable emergency. Incidence, agents, clinical features, treatment administered and therapeutic outcome of AP in children are comparable to the available national data. Preventive measures, strict legislative actions and restriction of availability of hazardous chemicals will reduce the incidence. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2016,

title = { A study on efficacy of intra-nasal midazolam spray in seizure patients: a prospective study},

author = {B. Sugunakar Reddy and Uppin Narayan Reddy and Mohd. Nasir Mohiuddin and Altaf Naseem and Mir Sumsam Ali Khurram and Javed Ullah and Ozlem Kaya},

url = {http://innovativejournal.in/index.php/ijmhs/article/view/1060/pdf_97},

doi = {10.15520/ijmhs.2016.vol6.iss3.120},

issn = {2277-4939},

year  = {2016},

date = {2016-06-01},

urldate = {2016-06-01},

journal = {Innovative Journal of Medical and Health Science},

volume = {6},

issue = {3},

pages = {98-100},

abstract = {An epileptic seizure is brief episodes of abnormal excessive or synchronous neuronal activity in the brain. The effect varies from uncontrolled jerking movements to momentary loss of awareness. The syndrome of recurrent and provoked seizures is termed epilepsy, but seizures can also occur in people who don’t have epilepsy it may vary on the patient’s genetic susceptibility.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naseem_2016d,

title = {Impact of iron deficiency on cognitive functions and effect of iron supplements in children between 5-10 years: Indian perspective},

author = {Altaf Naseem and Mir Sumsam Ali Khurram and Nizar Lalani},

url = {https://pediatrics.medresearch.in/index.php/ijpr/article/view/111/218},

doi = {10.17511/ij pr.2016.i05.08},

issn = {2349-3267},

year  = {2016},

date = {2016-05-31},

urldate = {2016-05-31},

journal = {Pediatric Review: International Journal of Pediatric Research},

volume = {3},

issue = {5},

pages = {313-322},

abstract = {Background: Data on iron deficiency anemia (IDA) and cognitive function in Indian children aged 5-10 years is limited. Objective: To study the extent of IDA, its impact on cognition and evaluate the effect of iron supplementation on cognitive function in children with IDA. Methods: Children aged 5-10  years (n=193) were grouped into overt (group I n=71 ,Ia- received iron supplements, Ib –without iron supplement), latent (group II, n=48, IIa- received iron supplements, IIb –without iron supplement)) anemia and non anemia (Group III, n=74) categories. Basic hematological investigations (HB, MCV, peripheral smear and total iron binding capacity) were done at baseline to categorize into groups. Cognitive function tests were performed at baseline and at the end of the study. Deworming with broad spectrum anthelmintic agent Albendazole (400mg  stat) followed by iron  supplements for 3 months was administered to Group Ia and IIa children. Results: Of 193 children, 119 (61.65%)  had  Iron  deficiency, seventy (36.27%) had overt anemia and 49(25.397%) had latent form. Mean±SD Haemoglobin at baseline was 11.80±1.71gm/dL, MCV 82.07±4.69 femolitres,  TIBC was 403.58 ± 58.77μ g/dL. Cognitive functions were significantly (p<0.005) higher in non anemic children. Iron supplements were administered for 3 months to 58 students. Treatment compliance was 96.0%. Hemoglobin>12gms/dL was seen in 80.83% (156/193) had <12 gms/dL, after iron supplements; Mean ± SD Haemoglobin was 12.76±1.39gm/dL and that of visual recall, digit span and clerical task changed from 5.63±1.08, 4.03±1.0, and 7.16±1.4, respectively to 6.34±0.82, 4.35±0.78 And 7.98±1.19 respectively. Higher scores were seen in those with haemoglobin>12 gms/dL.Conclusion: Non anemic children perform better than those with anemia; performance of those with latent anemia is better than those with overt anemia. Iron supplementation helps in improved performance in these children. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gul_2016,

title = {A rare case of anhidrotic ectodermal dysplasia in a six-year-old boy},

author = {Bismah Gul and Uppin Narayan Reddy and Swathi Chacham and Mir Sumsam Ali Khurram and Naila Mazher and Taha Mustafa and E. Apoorva},

url = {https://www.ijcasereportsandimages.com/archive/2016/002-2016-ijcri/CR-10608-02-2016-gul/ijcri-1060802201608-gul.pdf},

doi = {10.5348/ijcri-201621-CR-10608},

issn = {0976-3198},

year  = {2016},

date = {2016-02-01},

journal = {International Journal of Case Reports and Images},

volume = {7},

issue = {2},

pages = {127-131},

abstract = {Introduction: Ectodermal dysplasia is a rare, non-progressive, genetic disorder resulting from abnormal development of two or more tissues at a time which are derived from the embryonic ectoderm. It classically manifests with skin, eccrine gland, nail and hair changes, with an incidence of 1 in 1, 00,000 births. More than 170 different syndromes have been identified. X-linked recessive anhidrotic dysplasia (XLHED) being the most common type, which is expressed in males. Case Report: A six-year-old boy, was bought to the pediatric outpatient department with the complaints of fever on and off since month months. The parents gave history of recurrent episode of hyperpyrexia, with heat intolerance, absent sweating and delayed dentition in the past. On examination the child had peculiar facies, characterized by malar hypoplasia, flattening of nasal bridge, everted lips, wrinkled periorbital skin, pegged shaped tooth, low set ears, scanty, hypopigmented hair on the head; with absent eyebrows and eye lashes. Even after thorough evaluation and investigation, no focus of infection was found, ectodermal dysplasia was then considered and a skin biopsy done, which showed absence of skin appendageal structures. Conclusion: We report a rare case of anhidrotic ectodermal dysplasia in a 6-year-old boy, thus emphasizing the need for considering EDA as a differential diagnosis for neonates and infants with history of fever of unknown origin specially when associated with delayed dentition and

hypotrichosis. An early diagnosis would have prevented unnecessary antibiotic misuse. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rao_2015c,

title = {Congenital rubella syndrome in a term male neonate with patent ductus arteriosus and bilateral nuclear cataracts: a case report},

author = {S. Pratap Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and Soumya Anumula and Faraaz Adil and Burli Prithvi and Naila Mazher},

url = {https://journals.indexcopernicus.com/api/file/viewByFileId/364585},

issn = {2347-6559},

year  = {2015},

date = {2015-06-30},

urldate = {2015-06-30},

journal = {Scholars Journal of Medical Case Reports},

volume = {3},

issue = {6},

pages = {497-501},

abstract = {Transplacental transmission of rubella virus leads to Congenital Rubella Syndrome. It is comprised of

congenital cardiac defects (most commonly patent ductus arteriosus), cataracts and sensorineural hearing loss. While prematurity and intra uterine growth retardation are frequent accompaniments of congenital rubella syndrome, at times birth weight can be normal. The possibility of fetal anomalies due to rubella virus is highest in the first 12 weeks of gestation, which decreases thereafter. PDA is highly prevalent in premature neonates, where as its presence in term neonates signifies either intra uterine infection or genetic disease. A 39weeks, 3200grams, appropriate for gestational age, male neonate was born by vaginal delivery with normal APGARS. The neonate presented with respiratory distress, precardial activity and cardiac murmur on 4th day of life. Hence, congenital heart disease was considered and echocardiography revealed patent ductus arteriosus. While PDA is common in premature neonates, it is a rare manifestation in term newborn babies. The neonate also had bilateral nuclear cataracts in the eyes, implying congenital rubella syndrome and was investigated for the same. Other systemic findings like bilateral cryptorchidism, hepatosplenomegaly and thrombocytopenia were also evident. In addition there was unconjugated hyperbilirubinemia and elevated transaminases. There were no intra cranial calcifications in neurosonogram. Congenital rubella syndrome was confirmed as rubella IgM levels in both mother and neonate were elevated. The neonate received decongestive therapy for patent ductus arteriosus. We report a term, male appropriate for gestational age neonate with PDA and bilateral nuclear cataracts along with elevated rubella IgM levels confirming congenital rubella syndrome. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2015,

title = {Evaluation of lucidity in interpretation of medical prescriptions written in pediatric outpatient by the parents and attending pharmacists},

author = {Uppin Narayan Reddy and Sadiqua Anjum and J. Narsing Rao and Swathi Chacham and Mohd. Nasir Mohiuddin and Sana Afreen and Mir S. Adil and Mohd. Javeedullah},

url = {https://storage.googleapis.com/journal-uploads/ejpmr/article_issue/1435655058.pdf},

issn = {2394-3211},

year  = {2015},

date = {2015-06-05},

urldate = {2015-06-05},

journal = {European Journal of Pharmaceutical and Medical Research},

volume = {2},

issue = {4},

pages = {204-213},

abstract = {Introduction: there are various problems in understanding the prescriptions, interpreting and communicating have been documented across the health care. Medicines designed for the betterment of patients health can actually prove detrimental when misused. Therefore the medicines, side effects, usage, dosage and ingredients must be properly communicated. While most doctors and pharmacist can see the importance of patient’s knowledge of prescription when dealing with medicines, most of them hardly make appropriate efforts to communicate the same to them. Methodology: This is a cross sectional study done in the out-patient department of Princess Esra hospital, Hyderabad and the pharmacies attached to it from march to may 2014. It is a 1000 bedded teaching hospital, situated in Hyderabad, providing specialized tertiary level health care services to all strata of people. A total of 232 participants were enrolled in the study, out of which 202 could be followed up at the pharmacy to analyze drug dispensing. Aims and Objectives: This study aims at evaluation of adequacy of medical prescription written by pediatric practitioner and its understanding by the parent and the pharmacist .It also aims to assess the drug dispensing at the level of pharmacist and the parental understanding of the usage of the prescribed drugs. Results: it was noticed that among the antibiotics prescribed strength of the antibiotics was written only for 54.6% of the prescription while dose (100%), frequency (97.9%), and duration to be taken (99.4%) was adequately mention. When understanding the antibiotics in the prescription by parents was evaluated it was noticed that only 35.7% could understand the strength mentioned on the prescription while dose(70.9%), frequency( 68.8%) , duration to be taken (79.5%) could be understood by 70 – 80 % of parents. Conclusion: Antibiotics usage is very high compared to the usual requirement. They are chances of higher dose of antipyretics being given inadvertently due to prescription errors. Very high usage of antihistamines is seen which has been previously proved to be harmful for small children },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rao_2015b,

title = {A preterm very low birth rate male néonate with refractory hypoglycaemia and hyperinsulinema and hyperammonemia: a rare case report},

author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and Mohd. Ahmedulla Khan and Jakkampudi Nagasravani},

url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10504-05-2015-rao/ijcri-1050405201504-rao.pdf},

doi = {10.5348/ijcri-201543-CR-10504},

issn = {0976-3198},

year  = {2015},

date = {2015-05-01},

urldate = {2015-05-01},

journal = {International Journal of Case Reports and Images},

volume = {6},

issue = {5},

pages = {272-275},

abstract = {Introduction: Hypoglycemia is an important metabolic complication in neonates, more so in newborns with perinatal risk factors. Physiological immaturity of gluconeogenesis, lipolysis coupled with hyperinsulinemia contributes to hypoglycemia in small for gestational age (SGA) neonates. Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a hyperinsulinemic condition is an important differential diagnosis for intractable and refractory hypoglycemia. Hyperinsulinemic-hyperammonemia (HI/HA) syndrome, a rare autosomal dominantly inherited disorder, is the second most common cause for hyperinsulinemic-hypoglycemia in infancy. Both symptomatic as well as asymptomatic hypoglycemia involves the occipital cortex leading to cortical blindness, necessitating early etiological diagnosis and prompt intervention. We report a preterm male neonate with rare manifestations of refractory hypoglycemia, hyperinsulinemia and hyperammonemia. Case Report: A 30 weeks, 1300 grams male neonate, born by C-section had respiratory distress, requiring mechanical ventilation (MV) for 10 days. On 11th day of life, neonate developed recurrent apneic episodes along with jitteriness and seizures. Initial evaluation revealed low blood sugar levels which persisted despite high glucose infusion rate (GIR 12 mg/kg/min). There was hyperammonemia (serum NH3 levels 273 µg/dL) along with hyperinsulinemia. However, the serum cortisol, thyroid, growth hormone levels and blood lactate were normal. Similarly, metabolic screening for inborn errors of metabolism (IEM) was normal. Abdominal imaging with ultrasound and contrast-enhanced computed tomography (CT) scan did not reveal pancreatic hyperplasia. Persistent hypoglycemia, hyperinsulinemia along with hyperammonemia could suggest hyperammonemic hyperinsulinemic syndrome in this neonate. The infant responded to oral diazoxide. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Chacham_2015,

title = {Symptomatic late onset hypocalcemia in a full term female neonate with vitamin D deficiency due to maternal hypovitaminosis D: a rare case report},

author = {Swathi Chacham and Janampally Ravikiran and Uppin Narayan Reddy and J. Narsing Rao and Mahender Reddy and Imeduddin},

url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10505-05-2015-chacham/ijcri-1050505201505-chacham.pdf},

doi = {10.5348/ijcri-201544-CR-10505},

issn = {0976-3198},

year  = {2015},

date = {2015-05-01},

urldate = {2015-05-01},

journal = {International Journal of Case Reports and Images},

volume = {6},

issue = {5},

pages = {276-279},

abstract = {Introduction: Neonatal hypocalcemia (NH) is a common metabolic complication in neonates, more so in premature and high risk neonates. It is classified as early and late neonatal hypocalcemia. Early NH occurs in the first 24–48 hours of life while the late NH is observed at the end of the first week. Vitamin D deficiency is an important cause for hypocalcemic seizures in neonates, in developing countries. High rate of skeletal growth coupled with low vitamin D stores and maternal vitamin D deficiency makes them vulnerable to vitamin D deficiency. Case Report: A 2600 grams, term female neonate was born to a gravid 3 mother by C-section and had normal extra-uterine transition (APGAR score: 8&9 at 5 and 10 minutes of life). On eighth day of life, the neonate had multifocal clonic seizures with normal sensorium in between. No maternal risk factors were identified. There was no fever, lethargy, poor feeding, and clinical findings were unremarkable in the neonate. There was family history of neonatal seizures. Initial blood sugar and magnesium were normal. However, serum calcium levels were low (total 5.9 mg/dL, ionized 0.9 mg/dL) along with low phosphorous levels (1.7 mg/dL). Sepsis screen was negative, blood culture was sterile and cerebro spinal fluid analysis was normal. Similarly, neurosonogram, electroencephalogram, serum ammonia and lactate were normal, suggesting late onset hypocalcemic seizures. Both the neonatal and maternal vitamin D1 and 25-OH vitamin D were low, confirming maternal vitamin D deficiency causing neonatal vitamin D deficiency. The neonate responded to calcium and vitamin D supplementation with normal serum calcium levels in follow-up. Conclusion: We report a term, female neonate with late onset hypocalcemic seizures and vitamin D deficiency, due to maternal vitamin D deficiency. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mazher_2015,

title = {A rare case of unilateral left side multi cystic dysplastic kidney and contralateral vesico-ureteric reflux in a male neonate},

author = {Naila Mazher and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and Janampally Ravikiran and Jakkampudi Nagasravani and Aslam},

url = {https://www.ijcasereportsandimages.com/archive/2015/005-2015-ijcri/CR-10508-05-2015-mazher/ijcri-1050805201508-mazher.pdf},

doi = {10.5348/ijcri-201547-CR-10508},

issn = {0976-3198},

year  = {2015},

date = {2015-05-01},

urldate = {2015-05-01},

journal = {International Journal of Case Reports and Images},

volume = {6},

issue = {5},

pages = {290-295},

abstract = {Introduction: Multicystic dysplastic kidney (MCDK) is a rare congenital disorder, resulting from malformation of the kidney during fetal development. It could be unilateral, bilateral or segmental and bilateral MCDK is incompatible with survival. Unilateral MCDK occurs in 1 in 4300 live births and combined incidence of unilateral and bilateral MCDK is 1 in 3600 live births. The malformed kidney is non-functional with multiple irregular cysts of varying size, separated by dysplastic parenchyma along with absent pelvicaliceal system. Case Report: A 35-week, preterm, male neonate was born to a primigravid by C-Section. There was a history of second degree consanguinity. Antenatal ultrasonography at 17th week of gestation showed left side MCDK with oligohydramnios and without other malformations,which was confirmed by fetal magnetic resonance imaging (MRI). Postnatal ultrasonography also revealed left side MCDK with grade II vesico-ureteric reflux on the right side in micturating cystourethrogram and absent function in the affected kidney in dimercaptosuccinic acid (DMSA)scintigraphy. Conclusion: We report a preterm, male neonate with antenatally detected non-functional left side multicystic dysplastic kidney with postnatal confirmation and grade II vesico-ureteric reflex on the right side. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rao_2015,

title = {Late infantile metachromatic leukodystrophy in a two year-old boy: a case report},

author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Janampally Ravikiran and S. Pratap Rao and B. Sugunakar Reddy},

url = {https://www.ijcasereportsandimages.com/archive/2015/004-2015-ijcri/CR-10501-04-2015-rao/ijcri-1050104201501-rao.pdf},

doi = {10.5348/ijcri-201540-CR-10501},

issn = {0976-3198},

year  = {2015},

date = {2015-04-01},

urldate = {2015-04-01},

journal = {International Journal of Case Reports and Images},

volume = {6},

issue = {4},

pages = {228-232},

abstract = {Introduction: Metachromatic leukodystrophy (MLD) occurs due to cerebroside sulfatide accumulation in the extraneural and neural tissues. Arylsulfatase A (ARSA) enzyme deficiency leads to progressive focal or generalized demyelination. This rare disorder involves both central and peripheral nervous system. Case Report: We report a two-year-old boy, born of consanguineous marriage presenting with recurrent seizures from 13 months of age, followed by regression of milestones and spasticity from 15 months of age. Neurodegenerative disorder was considered initially and the child underwent neuroimaging followed by enzyme level assay. Magnetic resonance imaging scan (MRI) of brain revealed demyelination involving both cerebral cortex in the periventricular white matter with sparing of subcortical 'u' fibers and tigroid appearances /leopard skin sign, hallmark of metachromatic leukodystrophy. Normal β-galactosidase enzyme activity along with undetectable (ARSA) enzyme levels confirmed the diagnosis of late infantile variant of metachromatic leukodystrophy. Conclusion: A two-year-old boy presented with recurrent, generalized seizures, regression of milestones along with characteristic MRI findings and untraceable ARSA activity suggesting late infantile metachromatic leukodystrophy. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naseem_2015,

title = {Twenty nail dystrophy in 12-year-old male child: a case report},

author = {Altaf Naseem and Nayantara G. Rao},

url = {http://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_apr_cr15.pdf},

doi = {10.17354/ijss/2015/197},

issn = {2321-595X},

year  = {2015},

date = {2015-04-01},

urldate = {2015-04-01},

journal = {International Journal of Scientific Study},

volume = {3},

issue = {1},

pages = {234-235},

abstract = {Twenty nail dystrophy of childhood or trachyonychia is a rare acquired disorder. It is usually idiopathic and can be associated with other diseases. It is characterized by excessive longitudinal ridging, brittleness and thickening of nail plates involving 1-20 nails. We report an interesting case of a 12-year-old adolescent boy who presented to us with rough, opaque and lusterless nails, without any systemic involvement. Histopathological examination revealed the typical spongiosis described with this disease. This report also highlights the rationale for a nail biopsy and challenges faced for investigation of the underlying cause.

A conservative approach was successful in our patient.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ravikiran_2015,

title = {A rare case of maxillary sinus osteomyelitis with intraorbital, extraconal abscess in a term low birth weight twin},

author = {Janampally Ravikiran and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and Ekta Aggarwal and Anumula Soumya and Madhavi Nori},

url = {https://www.ijcasereportsandimages.com/archive/2015/003-2015-ijcri/CR-10485-03-2015-ravikiran/ijcri-1048503201585-ravikiran.pdf},

doi = {10.5348/ijcri-201524-CR-10485 },

issn = {0976-3198},

year  = {2015},

date = {2015-03-01},

urldate = {2015-03-01},

journal = {International Journal of Case Reports and Images},

volume = {6},

issue = {3},

pages = {132-137},

abstract = {Introduction: Acute osteomyelitis in neonates is a rare infectious disorder of bone leading to diagnostic and therapeutic challenge, more so in neonates. While the long bones are frequently affected sites, maxilla is rarely involved. Physiological immaturity of the immune system coupled with invasive diagnostic and therapeutic procedures render them susceptible for this condition, more so in premature, low birth weight infants. The most common organism causing osteomyelitis in neonates is Staphylococcus aureus. Lesion of the orbit as well as contiguous faciomaxillary and sinonasal inflammatory pathology often lead to proptosis in neonates. Case Report: We report a 15-day-old term female neonate (twin 1) presenting with non-traumatic periorbital swelling and purulent nasal discharge. The neonate also had failure to thrive. On clinical examination, the neonate was sick with sclerema and shock. There was right eye proptosis with edema and erythema. Initial diagnosis of periorbital abscess or orbital tumor was considered and the infant was investigated. Sepsis screen was positive with marked polymorphic leukocytosis. Also, the blood culture and culture from sinus scraping grew Staphylococcus aureus. Magnetic resonance imaging scan of the brain including orbit revealed osteomyelitis of maxilla and intraorbital extraconal mass with restricted diffusion, suggesting intraorbital abscess. The neonate responded to intravenous antimicrobials and decompression of the abscess. Although, the source of this major infection is unidentified, low birth weight, failure to thrive and poor socioeconomic status might have contributed. Conclusion: We report a term, low birth weight, female neonate with culture positive sepsis, maxillary sinus osteomyelitis and orbital abscess. Osteomyelitis of the maxilla is a rare entity and an important etiological factor for orbital abscess.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2014,

title = {Sinus histiocytosis and massive lymhadenaopathy (rosai-dorfman disease) in an 8 year old female child: a rare case report},

author = {Uppin Narayan Reddy and Swathi Chacham and Janampally Ravikiran and J. Narsing Rao and Jakkampudi Nagasravani and Abhijeet Ingle},

url = {https://www.ijmrhs.com/medical-research/sinus-histiocytosis-and-massive-lymphadenopathy-rosaidorfman-disease-in-an-8-year-old-female-child-a-rare-case-report.pdf},

doi = {10.5958/2319-5886.2015.00047.8},

issn = {2319-5886},

year  = {2015},

date = {2015-01-01},

urldate = {2015-01-01},

journal = {International Journal of Medical Research & Health Sciences},

volume = {4},

issue = {1},

pages = {254-257},

abstract = {Introduction: Sinus histiocytosis with massive lymphadenopathy is an infrequent, self-resolving histo-proliferative disorder of benign nature, also known as Rosai–Dorfman Disease. The typical manifestation of this

disease includes bilateral, progressive cervical lymphadenopathy along with pyrexia. Laboratory manifestations

consist of raised erythrocyte sedimentation rate, leukocytosis and hypergammaglobulinemia. Case report: An 8

year old female child presented with progressive, painful cervical and submandibular lymphadenopathy of three months duration. There was polymorphic leukocytosis and anemia along with raised Erythrocyte sedimentation rate and hypergammaglobulinemia. Fine Needle Aspiration cytology revealed sinus histiocytosis with massive lymphadenopathy, which was confirmed by the cervical lymph node biopsy. The histopathology revealed dilated sinuses filled with lympho plasma cells, large histiocytes and engulfed neutrophils (Emperipolesis). Conclusion: Massive, progressive bilateral cervical and sub mandibular lymphadenopathy, suggesting Sinus histiocytosis and massive lymphadenopathy-Rosai–Dorfman Disease. This was confirmed by Cytology, histopathology and immuno-histochemistry.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Chacham_2014,

title = {Epidermolysis bullosa in a small for gestational age preterm male neonate with two affected siblings: a case report},

author = {Swathi Chacham and Jakkampudi Nagasravani and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao and A. S. Kumar},

url = {https://www.ijcasereportsandimages.com/archive/2014/010-2014-ijcri/CR-10433-10-2014-chacham/ijcri-1043310201433-chacham.pdf},

doi = {10.5348/ijcri-2014122-CR-10433},

issn = {0976-3198},

year  = {2014},

date = {2014-10-01},

urldate = {2014-10-01},

journal = {International Journal of Case Reports and Images},

volume = {5},

issue = {10},

pages = {691-694},

abstract = {Introduction: Epidermolysis bullosa is a rare group of hereditary disorders, which are characterized by blistering of the skin and mucosa due to little or no apparent trauma. The severity can range from mild, localized skin blisters to generalized, systemic life-threatening disease and the treatment is mainly supportive. Dystrophic type of epidermolysis bullosa is one of the rarer forms. Skin fragility often leads to secondary skin infections and in turn generalized infection which can be lethal. Hence, the major challenge encountered in the care of a neonate with epidermolysis bullosa is optimum skin care and expert nursing care. A preterm, small for gestational age (SGA) neonate, has immature skin physiologically, which is a portal for systemic infection when compared to a term appropriate for gestational age neonate. The presence of blistering lesions in a preterm, SGA neonate further challenges the management. Case Report: We report a preterm, low birth weight (small for gestational age) male neonate, who had extensive bullous lesions and dystrophic nails in the first week of life. These lesions healed by scarring leading to stiffness of underlying joints and were complicated by secondary infection. There was history of consanguinity and previous two siblings also had similar lesions with contractures. Conclusion: A preterm male small for gestational age neonate born of consanguineous marriage, with the history of cutaneous bullous lesions in two siblings, presented with extensive bullous lesions and dystrophic nails, suggestive of dystrophic epidermolysis bullosa. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rao_2014,

title = {A 3 year old female child with type 1 sturge weber syndrome: a case report},

author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Naila Mazher and Afreen Mahmood and Jakkampudi Nagasravani},

url = {https://www.saspublishers.com/article/7699/},

doi = {10.36347/sjmcr.2014.v02i09.009},

issn = {2347-6559},

year  = {2014},

date = {2014-09-29},

urldate = {2014-09-29},

journal = {Scholars Journal of Medical Case Reports},

volume = {2},

issue = {9},

pages = {605-608},

abstract = {Sturge-Weber Syndrome (SWS) is a neuro-cutaneous disorder characterized by angiomas of face and the central nervous system. These angiomas, are the hallmark of SWS. While other phacomatoses are hereditary in nature, SWS occurs sporadically and with a frequency of 1 in 50,000. Mutations in GNAQ gene result in altered structure and innervation of cerebral vasculature. A three year old female child presented with recurrent seizures from infancy. General physical examination revealed several hyper-pigmented macules over the trunk and both lower limbs. A purple coloured port wine stain was found on the right side of the face. Imaging (Contrast enhanced CT) of the brain showed extensive pial enhancement in the right parieto-occipital lobe. MRI brain depicted ipsilateral enlargement of choroid plexus, characteristic finding of Sturge weber syndrome. We report a rare case of type 1 SWS with ipsilateral choroid plexus enlargement and typical pial enhancement.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2014d,

title = {Impact of maternal risk factors on the incidence of low birth weight (LBW neonates in Southern India)},

author = {Uppin Narayan Reddy and A. Vamshee Priya and Swathi Chacham and Sana Salim Khan and J. Narsing Rao and Mohd. Nasir Mohiuddin},

url = {https://www.ijmrhs.com/medical-research/impact-of-maternal-risk-factors-on-the-incidence-of-low-birth-weightneonates-in-southern-india.pdf},

doi = {10.5958/2319-5886.2014.00006.X},

issn = {2319-5886},

year  = {2014},

date = {2014-08-15},

urldate = {2014-08-15},

journal = {International Journal of Medical Research & Health Sciences},

volume = {3},

issue = {4},

pages = {813-818},

abstract = {Introduction: Birth weight is recommended as one of the twelve global indicators for monitoring the health of

the community and is an important determinant of adverse perinatal and neonatal events. LBW infant carries five times higher risk of dying in the neonatal period and three times more in infancy. Aims and Objectives: To

estimate the incidence of LBW and impact of various maternal and biosocial factors on the incidence of LBW

neonates in the study population. Material and methods: This prospective observational study was carried out in Princess Esra hospital, a tertiary care hospital in south India, over a period of six months. All consecutive LBW

(single ton) neonates admitted to the neonatal intensive care unit were enrolled, while those born of multiple

gestation and those with major congenital malformations were excluded. Results: A total of 300 neonates were

included in the present study out of which 150 were LBW and 150 weighed ≥2500 gm. Higher maternal weight

(>60kgs) had low incidence of LBW neonates (p value-0.03). Illiterate women had a remarkably higher incidence

of LBW babies (p value-0.001). In primigravida incidence of LBW was 61.2%. Higher incidence of LBW was

seen in mothers with oligo hydramnio’s. Conclusions: This study showed that maternal age, weight, literacy level and parity have a significant influence on the incidence of LBW. Incidence of LBW neonate in the study was 50%. Risk of having LBW neonates was higher in primigravida. There was a significant association between

LBW with oligo hydramnio’s and female gender. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mahmood_2014,

title = {A five year old male child with late infantile metachromatic leukodystrophy- a case report},

author = {Afreen Mahmood and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao},

url = {https://journals.sagepub.com/doi/10.1177/0883073814542948},

doi = {10.1177/0883073814542948},

issn = {1708-8283},

year  = {2014},

date = {2014-08-12},

urldate = {2014-08-12},

journal = {Journal of Child Neurology},

volume = {30},

issue = {4},

pages = {483-485},

abstract = {Metachromatic leukodystrophy is a rare disorder of myelin metabolism. This degenerative disorder results from the accumulation of cerebroside sulfatide within the myelin sheath of central and peripheral nervous system, due to deficiency of aryl sulfatase A enzyme. We report a 5-year-old male child, who presented with regression of milestones, recurrent seizures and spasticity from second year of life. Initially neurodegenerative disorder was considered and the case was investigated with neuroimaging and enzyme levels. Computed tomography (CT) of the brain showed hypodensities in the corpus callosum and bilateral periventricular and deep cerebral white matter suggestive of neurodegenerative disorder. Subsequently, magnetic resonance imaging (MRI) of the brain was done, which showed symmetrical hyperintensities in the periventricular white matter with classical sparing of subcortical “U” fibers. The β-galactosidase enzyme activity was normal; however, the activity of aryl sulfatase A enzyme was undetectable, confirming the diagnosis of late infantile variant of metachromatic leukodystrophy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rao_2014b,

title = {Congenital rubella syndrome with basal ganglia calcification and bilateral nuclear cataracts in a neonate: a rare entity},

author = {J. Narsing Rao and Swathi Chacham and Uppin Narayan Reddy and Jakkampudi Nagasravani and Naila Mazher and Syed Taha Mustafa},

url = {https://www.saspublishers.com/article/7648/},

doi = {10.36347/sjmcr.2014.v02i07.015},

issn = {2347-6559},

year  = {2014},

date = {2014-07-29},

urldate = {2014-07-29},

journal = {Scholars Journal of Medical Case Reports},

volume = {2},

issue = {7},

pages = {470-472},

abstract = {In-utero transmission of rubella virus during pregnancy leads to congenital Rubella syndrome (CRS), which is characterized by cataracts, deafness and sensorineural hearing loss. While the nuclear cataract is the most frequently occurring abnormality, basal ganglia calcification is a rarer manifestation. The Risk of fetal transmission of rubella virus is highest during the first 12 weeks of gestation and decreases afterwards. A 36weeks, 2600grams male neonate was born by vaginal delivery with normal APGARS. The neonate was admitted on third day of life with complaints of yellowish discoloration of the skin and sclera. On examination, the neonate had mild hypotonia, icterus up to the legs and systolic murmur on cardiac examination. Interestingly, the ophthalmological examination revealed bilateral nuclear cataracts. Chest radiograph showed cardiomegaly and ECHO revealed PDA (Patent Ductus Arteriosus). Hence, CRS was suspected and further evaluation was done. There was thrombocytopenia, mild unconjugated hyperbilirubinemia with mild elevation of transaminases. Another rare finding was basal ganglia calcification on neurosonogram. TORCH profile in both mother and baby showed elevated rubella IgM levels confirming CRS. The neonate received supportive and symptomatic treatment. We report a preterm, male appropriate for gestational age neonate with congenital rubella syndrome and its rare manifestation of basal ganglia calcification.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nagasravani_2014,

title = {A rare case of ataxial telangiectasia in a nine year old female child},

author = {Jakkampudi Nagasravani and Swathi Chacham and Uppin Narayan Reddy and J. Narsing Rao and S. Pratap Rao and Afreen Mahmood},

url = {https://www.pedneur.com/article/S0887-8994(14)00399-3/fulltext},

doi = {10.1016/j.pediatrneurol.2014.06.022},

issn = {0887-8994},

year  = {2014},

date = {2014-07-15},

urldate = {2014-07-15},

journal = {Pediatric Neurology},

volume = {51},

issue = {4},

pages = {583-584},

abstract = {Ataxia telangiectasia (A-T) is a rare multisystemic disorder with autosomal recessive inheritance. It is characterized by oculocutaneous telangiectasia, recurrent sinopulmonary infections, and neurodegeneration manifesting as ataxia. Progressive immunodeficiency and radiation-induced chromosomal breakage are hall marks of A-T. It has genetic and clinical heterogeneity, and the responsible gene (ATM gene) is located at chromosome 11q22-23. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2014b,

title = {A rare case of buphthalmos and bilateral nuclear cataracts in a neonate with congenital rubella syndrome},

author = {Uppin Narayan Reddy and Swathi Chacham and J. Narsing Rao and A. Vamshee Priya and Afreen Mahmood and Jakkampudi Nagasravani and Mohd. Ahmedulla Khan},

url = {https://www.jemds.com/data_pdf/swathi%20chacham.pdf},

doi = {10.14260/jemds/2014/2847},

issn = {2278-4748},

year  = {2014},

date = {2014-06-23},

urldate = {2014-06-23},

journal = {Journal of Evolution of Medical and Dental Sciences},

volume = {3},

issue = {25},

pages = {6965-6969},

abstract = {BACKGROUND: Congenital rubella syndrome (CRS) is the second leading cause of non‐traumatic childhood cataracts in India. While nuclear cataract is the most common abnormality reported in CRS, congenital glaucoma is a rarer manifestation. CASE REPORT: A 34weeks low birth weight, male neonate was born by vaginal delivery with normal APGARS. The neonate had sparse hypo pigmented hair over the scalp, along with hypopigmented eye brows and eye lashes. There were erythematous lesions over palms, soles and groin region. Eye examination revealed bilateral nuclear cataracts along with buphthalmos. The neonate also had clinical manifestations of PDA, which was confirmed by 2-D Echo. Systemic involvement was seen as hepatosplenomegaly and bilateral cryptorchidism. Hence CRS was suspected and further evaluation was done. There was thrombocytopenia, mild unconjugated hyperbilirubinemia with elevated transaminases. Neurosonogram was normal and there were no intra cranial calcifications. TORCH profile in both mother and baby showed elevated rubella IgM levels confirming CRS. The neonate received supportive and symptomatic treatment. DISCUSSION: congenital nuclear cataracts are reported in 60-80% of CRS, while buphthalmos is rarely seen, more so in neonatal period. PDA occurs in 50% of CRS and two-thirds have hepatosplenomegaly. Rubelliform rash is infrequent in neonates with CRS. CONCLUSION: We report a preterm low birth weight, male neonate with congenital rubella syndrome and its rare manifestations. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reddy_2014c,

title = {A rare case of Griscelli's syndrome with review of literature},

author = {Uppin Narayan Reddy and J. Narsing Rao and Swathi Chacham and Afreen Mahmood and Jakkampudi Nagasravani},

url = {https://jemds.com/data_pdf/Afreen%20Mahmodd.pdf},

doi = {10.14260/jemds/2014/2831},

issn = {2278-4748},

year  = {2014},

date = {2014-06-17},

urldate = {2014-06-17},

journal = {Journal of Evolution of Medical and Dental Sciences},

volume = {3},

issue = {25},

pages = {6874-6877},

abstract = {INTRODUCTION: Griscelli syndrome is a rare autosomal recessive disorder characterized by partial albinism and immunodeficiency. The characteristic features include silver hair due to clumped melanosomes in hair shaft. Other features include hepatospleenomegaly, hepatitis, pancytopenia and immune abnormalities. CASE REPORT: A seven years old male child presented with partial albinic features and history of recurrent respiratory tract infection. The child had fever since 2months along with hepatospleenomegaly, pancytopenia and thrombocytopenic purpura. These rare clinical manifestations were diagnosed as GS which was confirmed by bone marrow biopsy and light microscopy of hair shaft. The mean patient age of survival is 5years. As early

diagnosis can improve the outcome in such cases, a finding of partial albinism should alert the diagnosis of Griscelli’s syndrome. CONCLUSION: We report a rare case of GS with characteristic manifestation surviving beyond the mean age of reported survival. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2014,

title = {Infantile Pompes disease in a female neonate with significant family history: a case report},

author = {Sana Salim Khan and Swathi Chacham and S. Pratap Rao and Uppin Narayan Reddy and J. Narsing Rao},

url = {https://www.saspublishers.com/article/7602/},

doi = {10.36347/sjmcr.2014.v02i05.008},

issn = {2347-6559},

year  = {2014},

date = {2014-05-29},

urldate = {2014-05-29},

journal = {Scholars Journal of Medical Case Reports},

volume = {2},

issue = {5},

pages = {333-335},

abstract = {Pompes disease is a rare metabolic myopathy of autosomal recessive inheritance. It is caused by the deficiency of lysosomal enzyme acid alpha-glucosidase, which results in lysosomal and cytoplasmic glycogen accumulation. A wide spectrum of disease exists, varying from hypotonia and severe hypertrophic cardiomyopathy in infancy, to a milder form which manifests in adulthood. In either condition, the involvement of several systems leads to progressive weakness and disability. We report a six month old female infant who presented with hypotonia, developmental delay and hypertrophic cardiomyopathy. Significantly elevated CPK and LDH levels coupled with reduced acid α glucosidase activity, confirmed the diagnosis of Infantile Pompes disease. This infant had recurrent respiratory infections, failure to thrive and succumbed to death, due to hypertrophic cardiomyopathy at one year of age. The younger sibling was a carrier for pompes disease and there was a family history of hypertrophic cardiomyopathy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Anjum_2014,

title = {Assessment of parental understanding of pediatric medical prescriptions},

author = {Sadiqua Anjum and Mohd. Nasir Mohiuddin and Uppin Narayan Reddy and J. Narsing Rao and Sana Afreen and Mir S. Adil and Mohd. Javeedullah},

url = {https://www.ijmrhs.com/medical-research/assessment-of-parental-understanding-of-paediatric-medical-prescriptions.pdf},

doi = {10.5958/2319-5886.2014.00393.2},

issn = {2319-5886},

year  = {2014},

date = {2014-05-21},

urldate = {2014-05-21},

journal = {International Journal of Medical Research & Health Sciences},

volume = {3},

issue = {3},

pages = {541-546},

abstract = {Medical prescriptions are bound to be misinterpreted by patients and pharmacists if not properly conveyed. Pediatric prescriptions differ from adult prescriptions having wide variation in doses and formulations.There is a need to evaluate the lacunae in the parental understanding of pediatric prescriptions.Aims and objective: To evaluate the parental understanding ofpediatric prescription and to evaluate the adequacy of communication with the physician and pharmacist regarding the same.Material and methods: 550 parents were enrolled and their literacy level was noted.They were subjected to modify MUSE questionnaire.Physician’s prescription was analyzed in terms of ease of understanding by parents. These parents were followed up till the pharmaciesand the pharmacist understanding of prescription was analyzed and their communication with parents regarding drug usage was noted. Finally, ease of usage of drugs by parents was noted. Results:MUSE scale was modified to suit pediatric prescription understanding by parents and also additional questions were asked to include complete parental understanding of doctor’s prescription. Majority of parents failed to completely understand the written prescription. Though around 80% of pharmacist could understand the prescription, their communication with parents was poor resulting in difficulty for parents to even enquire about medicines from them. Parental overall understanding of prescription increased with their literacy levels. Conclusion:Not all prescriptions are completely understood by parents as well as a pharmacist. This can lead to misuse of drugs. Efforts to explain the drug usage are not adequate enough from the doctor or the pharmacist. While communicating literacy levels of parents is not being considered which may further worsen the understanding ability.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}