@article{Fatima_2024b,

title = {Seroprevalence of SARS-CoV-2 IgG antibodies in health care workers and the associated risk factors during the covid-19 pandemic period at a tertiary care heatlh center in South India},

author = {Sarwat Fatima and Ahmed Abdul Bari Hazari and Deepika Handa},

url = {https://pdf.ipinnovative.com/pdf/23488},

doi = {10.18231/j.ijmmtd.2024.056 },

issn = {2581-4753 },

year  = {2024},

date = {2024-12-12},

urldate = {2024-12-12},

journal = {IP International Journal of Medical Microbiology and Tropical Diseases},

volume = {10},

issue = {4},

pages = {329-336},

abstract = {Background: Most of the published studies across the globe so far have demonstrated a highly variable seroprevalence rate of SARS-CoV-2 IgG antibodies in health care workers [HCW’s] during the pandemic period. Multiple risk factors were studied that influenced the seropositivity. 

Aim & Objective: The primary aim of the study was to determine the seroprevalence of SARS-CoV-2 IgG in HCW’s in local settings during the pandemic period. The secondary objective was to categorize the HCW’s based on the history of symptoms of covid-19 and also to evaluate the relation between the various risk factors and seropositivity amongst the HCW’s.

Materials and Methods: A cross sectional prospective study was conducted on health care workers at a tertiary care hospital in Telangana state during the pandemic period between March to April 2021. Following enrollment and verbal consent from the participants descriptive data was collected using a validated questionnaire. SARS-CoV-2 IgG antibodies estimation was done using ELFA technology after obtaining IERB clearance.

Results: Of the 230 enrolled participants 141 [61.30%] fulfilled the inclusion criteria. The overall SARS-CoV-2 IgG seropositivity in the present study was 48 [34.04%]. Of the 72 [51.06%] symptomatic HCW’s, 19 [26.38%] were seropositive and of the 69 [48.93%] asymptomatic, 29 [42.02%] were seropositive. Among the various risk factors studied none were found to be significantly associated with seropositivity.

Conclusion: in the present study a greater number of asymptomatic HCW’s were found seropositive which could be due to several of the reasons discussed below one being silent transmission of the virus and demands further enquiry into the cause by improved research methodology.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Golla_2024,

title = {Impact of diabetes on clinical characteristics and angiographic findings in young adults with ST-elevation myocardial infarction: a cross-sectional study},

author = {Abhishek Golla and Mohammed Hidayathulla and Sowmya Chavala and Rajashekar Reddy Gurrala and Sayed Mohammed Hussain Bangi},

url = {https://www.jcdr.net/articles/PDF/20401/75961_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_OM)_PFA(IS)_PN(IS).pdf},

doi = {10.7860/JCDR/2024/75961.20401},

isbn = {0973-709X},

year  = {2024},

date = {2024-12-01},

urldate = {2024-12-01},

journal = {Journal of Clinical and Diagnostic Research},

volume = {18},

issue = {12},

pages = {OC01-OC04},

abstract = {Introduction: The prevalence of diabetes among young patients with ST-Elevation Myocardial Infarction (STEMI) is increasing, but its impact on this population remains understudied. Limited data on diabetes in young patients with STEMI exist. The presence of diabetes among young patients experiencing STEMI deserves special consideration, as it manifests with unique clinical patterns and can significantly impact their active lifestyle.

Aim: To determine the effect of diabetes and associated clinical characteristics in young patients with STEMI.

Materials and Methods: A cross-sectional study was conducted at a tertiary care centre in India between April 2018 and December 2019. Fifty-one STEMI patients aged below 40 years were enrolled and categorised into diabetic (n=23) and non diabetic (n=28) groups based on glycated haemoglobin (HbA1c) levels. Clinical characteristics, laboratory parameters and angiographic findings were compared between the groups. This study analysed continuous variables using Student’s t-test and Analysis of Variance (ANOVA) (expressed as mean±SD), and categorical variables using Chi-square or Fisher’s exact tests (shown as n, %). A p-value of < 0.05 was considered significant.

Results: The mean age was 35.6±3.4 years, with 80.4% male predominance. Diabetic patients showed higher prevalence of dyslipidaemia (p-value=0.009), hypertension (p-value=0.043), and metabolic syndrome (p-value=0.002). They also exhibited significantly higher levels of total cholesterol, triglycerides and Low-Density Lipoprotein Cholesterol (LDL-C). Anterior Wall Myocardial Infarction (AWMI) was predominant in both groups (p-value=0.442). Single-Vessel Disease (SVD) was most common, but Triple-Vessel Disease (TVD) was observed exclusively in diabetic patients (p-value=0.198). The Left Anterior Descending (LAD) artery was the most involved vessel in both groups.

Conclusion: Compared to non diabetic patients, young STEMI patients with diabetes demonstrated a more adverse cardiovascular risk profile and lipid abnormalities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Electrolytes imbalance in management of electrical burns},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/electrolytes-imbalance-in-management-of-electrical-burns/NDExNjA=/?is=1&b1=&k=},

issn = {2249-555X},

year  = {2024},

date = {2024-11-30},

journal = {Indian Journal of Applied Research},

volume = {14},

issue = {11},

pages = {32-34},

abstract = {Aim of treatment is to achieve skin cover to prevent infection and to allow early mobilization. Electrical injuries are a

relatively uncommon. Adult electrical injuries usually occur as an occupational hazard, whereas children are primarily

injured accidentally. The spectrum of electrical injury is very broad, ranging from minimal injury to severe multi organ involvement, with both occult and delayed complications and death. This is a prospective study from OWAISI HOSPITAL & RESEARCH CENTRE, DECCAN COLLEGE OF MEDICAL SCIENCES, HYDERABAD. A total of 100 patients presenting from June 2023 to September 2024 were included. Patients were treated with surgical excision 21 (21.53 %), fasciotomy 16 (16.43 %), escharotomy 77 (77.62 %), and amputation 10 (10.21 %). In all patients debridement was performed. After follow-up, there was 6.64 % (6 patients) mortality. Minimal mortality may be due to less surface area involved or no visceral injury. Patients survived with morbidity due to amputation. Initial management of electrical burn is imperative to optimize function and minimize long-term scarring. However, further studies are required regarding flap repair and microsurgery to minimize the rate of amputation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Iron folic acid deficiency in pregnant women with cleft lip and palate deformities},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/iron-folic-acid-deficiency-in-pregnant-women-with-cleft-lip-and-palate-deformities/NjAxNzg=/?is=1&b1=4&k=1},

issn = {2277-8179},

year  = {2024},

date = {2024-11-30},

journal = {International Journal of Scientific Research},

volume = {13},

issue = {11},

pages = {82-84},

abstract = {The Orofacial clefts occur when the lips or the roof of the mouth do not fuse properly during the early weeks of pregnancy. There is strong evidence that periconceptional use of folic acid can prevent neural tube defects but its effect on oral clefts has generated debate. To identify factors associated with suboptimal periconceptional use of folic acid and its potential effect on oral clefts. The population-based infant cohort of the national Growing Up in Indian study, which consists of 10,134 9-month-old infants. Data collection comprised questionnaires conducted by interviewers with parents in parents' homes. Characteristics of mothers who did or did not take folic acid before and during pregnancy, as well as the effect of folic acid use on the prevalence of cleft lip and palate were recorded. The prevalence of cleft lip and palate was 1.92 (94% confidence interval [CI] = 1.21 to 2.88) per 500 9-month-olds. The odds ratio for cleft lip was 2.24-fold higher (92% CI = 1.11 to 8.10, P = 0.006) for infants of mothers who did not take folic acid during

the first 3 months of pregnancy, when compared with those who did have a folate intake during the first trimester. Folic acid use was suboptimal in 32.2% (94% CI = 32.2 to 35.1) of the sample. These findings support the hypothesis that taking folic acid may partially prevent cleft lip and palate. They are particularly relevant for GPs, because they are usually the first port of call for women before and during early pregnancy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bushra_2024,

title = {Molecular basis of sepsis: A new insight into the role of mitochondrial DNA as a damage-associated molecular pattern},

author = {Bushra and Shaik Iqbal Ahmed and Safia Begum and Maaria and Mohammed Safwaan Habeeb and Tahmeen Jameel and Aleem Ahmed Khan},

url = {https://www.sciencedirect.com/science/article/abs/pii/S1567724924001259?via%3Dihub},

doi = {10.1016/j.mito.2024.101967},

issn = {1567-7249},

year  = {2024},

date = {2024-11-01},

urldate = {2024-11-01},

journal = {Mitochondrion},

volume = {79},

issue = {suppl},

pages = {101967},

publisher = {Elsevier BV},

abstract = {Sepsis remains a critical challenge in the field of medicine, claiming countless lives each year. Despite significant advances in medical science, the molecular mechanisms underlying sepsis pathogenesis remain elusive. Understanding molecular sequelae is gaining deeper insights into the roles played by various damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) in disease pathogenesis. Among the known DAMPs, circulating cell-free mitochondrial DNA (mtDNA) garners increasing attention as a key player in the immune response during sepsis and other diseases. Mounting evidence highlights numerous connections between circulating cell-free mtDNA and inflammation, a pivotal state of sepsis, characterized by heightened inflammatory activity. In this review, we aim to provide an overview of the molecular basis of sepsis, particularly emphasizing the role of circulating cell-free mtDNA as a DAMP. We discuss the mechanisms of mtDNA release, its interaction with pattern recognition receptors (PRRs), and the subsequent immunological responses that contribute to sepsis progression. Furthermore, we discuss the forms of cell-free mtDNA; detection techniques of circulating cell-free mtDNA in various biological fluids; and the diagnostic, prognostic, and therapeutic implications offering insights into the potential for innovative interventions in sepsis management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Hemangiomas and vascular malformations},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood },

url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/article/hemangiomas-and-vascular-malformations/MzAyNzk=/?is=1},

issn = {2277-8160},

year  = {2024},

date = {2024-10-31},

journal = {Global Journal for Research Analysis},

volume = {13},

issue = {10},

pages = {85-86},

abstract = {Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specifc morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies. Vascular malformations and hemangiomas can cause significant morbidity and even mortality in both children and adults. For a number of reasons, physicians often confuse these lesions. The nomenclature for classifying these lesions is often used interchangeably and inappropriately. Clinically significant malformations are uncommon, and patients with these malformations are rarely encountered in primary medical facilities, rendering most physicians inexperienced in providing optimal care. Radiologists may become involved in the care of these patients when imaging or imaging-guided therapy is requested; therefore, knowledge of the imaging and treatment of these patients is essential. This article reviews the clinical and imaging approaches to vascular malformations and hemangiomas used in the multidisciplinary clinic, stressing a multidisciplinary approach, a practical

categorization scheme, characteristic imaging findings, and commonly encountered clinical scenarios.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024e,

title = {Awake bruxism in a patient with advanced alzheimer’s disease: an epiphenomenon of anxiety or marker of advanced disease},

author = {Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/09000/awake_bruxism_in_a_patient_with_advanced.35.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00401},

issn = {0028-3886},

year  = {2024},

date = {2024-10-31},

urldate = {2024-10-31},

journal = {Neurology India},

volume = {72},

number = {pmid39428794},

issue = {5},

pages = {1103-1104},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Cefoxitin and oxacillin resistance conundrums},

author = {Grishma Vijaykumar Kulkarni},

url = {https://journalsajrm.com/index.php/SAJRM/article/view/395},

doi = {10.9734/sajrm/2024/v18i11395},

issn = {2582-1989},

year  = {2024},

date = {2024-10-29},

journal = {South Asian Journal of Research in Microbiology},

volume = {18},

issue = {11},

pages = {1-11},

abstract = {Recently, mecA negative Staphylococcus aureus strains with decreased susceptibility to oxacillin and cefoxitin have been sporadically reported worldwide. They are called as borderline oxacillin resistant Staphylococcus aureus (BORSA). Almost, more than 30% of such strains are often misinterpreted and reported as MRSA (methicillin resistant Staphylococcus aureus ) due to the hyperproduction of beta lactamase enzyme and other reasons which results in invitro reduced

susceptibility to oxacillin as well as cefoxitin. Similar phenomenon is quite common in other staphylococci micrococci and macrococci. In order to identify beta lactamase hyperproducing staphylococci and other gram positive cocci and to avoid fals e reporting as methicillin resistant, a one year prospective study was conducted in Deccan college of medical sciences, Hyderabad, Telangana state, India in 2023. During one year duration, 5630 inpatient (IP) and 823 outpatient

(OPD) samples accounting for total 6453 cultures were received in the microbiology laboratory. Out of this,100 cultures of different samples showing pure growth of gram positive cocci suggestive of staphylococci, micrococci and other Gram positive cocci were included in the present study and tested against different antibiotics panel as per CLSI guidelines (Clinical and Laboratory Standards Institute.) Inclusion of amoxiclav disc to the antibiotics test panel as per recommendation by the special phenotypic methods for the detection of antibacterial resistance in the manual of clinical

microbiology was helpful to detect the beta lactamase hyperproducers (BHP) and helped to report correct identification of the organisms and curtailed the mismanagement of more than 95% of the patients. T herefore, I do recommend to differentiate borderline from true methicillin resistant strains to streamline the antibiotic therapy and hence further avoidance of selection of the resistant strains.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2024b,

title = {Effectiveness, utility, and economic analysis of three-drug treatment vs two-drug treatment in chronic obstructive pulmonary disease patients},

author = {Syed Aamir Ali and Subhranshu Panda and M. Aleemuddin Naveed},

url = {https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1126},

doi = {10.5005/jp-journals-11010-1126},

issn = {2277-9019},

year  = {2024},

date = {2024-09-30},

urldate = {2024-09-30},

journal = {Indian Journal of Respiratory Care},

volume = {13},

issue = {3},

pages = {146-151},

abstract = {Aim and background: Inhaled corticosteroids (ICS) and bronchodilators remain the mainstay of therapeutic modalities available for the management of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the effectiveness, utility, and economic analysis of a three-drug treatment vs a two-drug treatment in COPD patients. Materials and methods: An observation was conducted at a superspecialty hospital in Hyderabad. Out of the 115 patients recruited from the inpatient and outpatient wards of the Pulmonology Department, 55 patients received triple therapy containing ICS, long-acting β-agonists (LABA), and long-acting muscarinic antagonists (LAMA), whereas 60 patients were treated with dual therapy comprising ICS/LABA. Cost-effectiveness was assessed based on forced expiratory volume in 1 second (FEV1) (FEV1% predicted), St George's respiratory questionnaire (SGRQ) scores, SGRQ responder ratio, COPD assessment test (CAT) scores, and incremental cost-effectiveness ratio (ICER). Results: Results signified the enhanced potency of three-drug treatment vs two-drug treatment as proven by the improvement in average difference from initial values in (1) FEV1% predicted value of 4.36 [95% confidence interval (CI) (2.9–5.82)], (2) SGRQ scores of −6.76 [95% CI (−2.14 to −11.38)], SGRQ responder ratio of 13.25 (3.72–47.24), CAT scores of −5.15 [95% CI (−9.87 to −0.43)] and ICER of 3522 [95% CI (14682 to −7638)]. Conclusion: Triple therapy comprising LABA, LAMA, and ICS can optimize lung function and improve clinical outcomes, leading to overall enhancement of well-being compared to LABA/ICS dual therapy in moderate to severe COPD patients. Clinical significance: Three-drug treatment comprising ICS/LABA/LAMA is an effective and cost-effective therapeutic approach for managing moderate and severe COPD compared to ICS/LABA dual therapy. This is evidenced by improvements in spirometry values (FEV1% predicted) and health-related quality of life (HRQoL).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Basith_2024,

title = {Efficacy of Tru-cut biopsy of the cervical lymphnodes over FNAC for detecting MTB using CBNAAT histopathology and cultures},

author = {Mohammed Abdul Basith and M. Aleemuddin Naveed and Ashfaq Hasan and Fahad Abdullah Bin Breik and Syed Mahmood Ahmed and Shireen Adeeb Mujtaba Ali},

url = {https://journals.lww.com/jdyu/fulltext/2024/13030/efficacy_of_tru_cut_biopsy_of_the_cervical.11.aspx},

doi = {10.4103/jdrysruhs.jdrysruhs_32_24},

issn = {2950-5356},

year  = {2024},

date = {2024-09-27},

urldate = {2024-07-01},

journal = {Journal of Dr. YSR University of Health Sciences},

volume = {13},

issue = {3},

pages = {247–252},

publisher = {Wolters Kluwer - Medknow},

abstract = {Introduction: The present study was carried out to see the usefulness of Tru-cut biopsy over fine needle aspiration (FNA) in diagnoses of tuberculosis (TB) cervical lymphadenopathy and comparing their yields by performing ZN staining, culture, cytology, histopathology, and CBNAAT.

Observation and Results: It was found that the yield of Tru cut was significantly more in ZN staining and histopathology. Even though the yield was more in culture and CBNAAT also, it was not statistically significant. FNA is a popular method which is very widely used, but it has a low yield. From the results, it was inferred that for FNA, the positive rate was 27.6%, 38.4%, 67.7%, and 43% for the four modalities of ZN staining, CBNAAT, cytology, and acid-fast bacilli cultures, respectively. Comparatively, for Tru-cut biopsy, the positive rate was 36.9%, 46.2%, 92.3%, and 47.7%, respectively, in all four modalities. It was noticed that the highest value was recorded for histopathology, followed by culture and CBNAAT for Tru-cut biopsy procedures. Comparatively, FNA showed the highest negative rate for ZN staining and CBNAAT.

Conclusion: The present study also highlights the importance of Tru-cut biopsy over FNA. It is one of the emerging techniques which if used properly could offer a better yield. Further results and conclusions are discussed in the paper.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024f,

title = {Unilateral asymptomatic multiple cerebral microbleeds: a very rare radiological entity},

author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka and Sravan Kumar Marupaka},

url = {https://journals.lww.com/annalsofian/fulltext/2024/27050/unilateral_asymptomatic_multiple_cerebral.18.aspx},

doi = {10.4103/aian.aian_383_24},

issn = {0972-2327},

year  = {2024},

date = {2024-09-06},

urldate = {2024-09-06},

journal = {Annals of Indian Academy of Neurology},

volume = {27},

number = {pmid39240195},

issue = {5},

pages = {573-575},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024d,

title = {Basal cistern sparing pattern of subarachnoid hemorrhage: an imaging clue for SAH beyond aneurysm},

author = {Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/07000/basal_cistern_sparing_pattern_of_subarachnoid.40.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00705},

issn = {0028-3886},

year  = {2024},

date = {2024-08-31},

urldate = {2024-08-31},

journal = {Neurology India},

volume = {72},

number = {pmid39216057},

issue = {4},

pages = {892-893},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sameera_2024,

title = {Study of correlation of morphometric and radiological parameters of hyoid bone In the population of Telangan},

author = {Syeda Sadia Sameera and Hajira Fatima and Zafar Sultana Abdul Saleem and Shaik Hussain Saheb},

url = {https://www.afjbs.com/uploads/paper/ab628f2e1eafc839b644aa846cf907a4.pdf},

doi = {10.48047/AFJBS.6.Si4.2024.6127-6133},

issn = {2663-2187},

year  = {2024},

date = {2024-08-15},

urldate = {2024-08-15},

journal = {African Journal of Biological Sciences},

volume = {6},

issue = {Si4},

pages = {6127-6133},

abstract = {Background: The hyoid bone in humans is anatomically positioned in the anterior, upper aspect of the neck and is typically horseshoe-shaped. This bone plays a vital role in forensic studies as an indicator for diagnosing asphyxia deaths due to hanging and strangulation. Since modern facilities have improved the accuracy of measurement and study, present work correlates the morphometric features from the dry cadaveric specimens, as well as scanned images from living hyoid. This will generate useful data for medicolegal and anthropometric uses. This study conducted to corelate the morphometric and radiological parameters of adult hyoid bone in the population of Telangana. Material and Methods: We conducted this study with 40 dried specimens of hyoid bones. We have measured the parameters using vernier caliper and correlated in living using CT scan. In present study we have recorded the parameters like, Length of right greater cornu, Length of left greater cornu, Anteroposterior distance at the middle of body of hyoid bone, Length of Hyoid bone. Results: All the morphometric parameters of hyoid bone corelate with the radiological parameters. There is no significant difference between the dry bone and CT scan measurements in case of length of body of hyoid bone where as there is significant difference between the other three parameters. Conclusion: The findings of this study may be helpful for anthropometry and medicolegal importance and the surgeries in this reason. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Yeshwanth_2024,

title = {Mitochondrial potential and Nd1 gene expression analysis in platelets for quality assessment},

author = {Asapanna Naga Sai Venkata Yeshwanth and Sara Jabeen and Aleem Ahmed Khan and Nusrath Fathima},

url = {https://www.scholasticopenaccess.org/SCMS/SCMS-02-0043.pdf},

year  = {2024},

date = {2024-07-16},

urldate = {2024-07-16},

journal = {Scholastic Medical Sciences},

volume = {2},

issue = {5},

pages = {1-4},

abstract = {Background: Platelets are the tiniest blood particles, and their shape shows how lively they are. They are largely concerned with hemostasis, or the process of starting blood coagulation. The diverceful activity of platelet and molecules released from platelet storage granules are both necessary for these various activities. Initiating homeostasis, an inflammatory response, and an immune response at the site of injury during the acute phase

of wound healing, as well as encouraging angiogenesis and tissue regeneration during the repair phase, is examples of how these platelet activities interact synergistically. Therefore mitochondria function/quality plays various important roles in several disease processes. Several studies have demonstrated mitochondria dysfunction in various chronic degenerative diseases (ex: cardiovascular diseases; Type 2 diabetes). Hence, there is need for quality assessment platelet mitochondrial DNA for platelet functions. Materials and Methods: Platelets were incubated with Rhodamine 123 exclusive dye to assess the membrane potential. The cytotoxicity of platelets were assed at different dilution point using MTT assay. The activity of platelet mitochondrial (mtDNA) was assessed using ND1 gene. Results: The aggregation of platelets with Rhodamine dye indicates the active state of platelets. The decline of platelets with high concentration MTT assay was observed. The activity of mtDNA in platelets the ND1 gene and internal control 12s gene were expressed at same indicating the active

presence of mtDNA in platelets. Conclusion: The Rhodamine 123 stain with platelet indicates that the presence of mitochondrial membrane potential. The ND1 gene expression indicates the quality of mitochondrial DNA in platelets.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vuppala_2024,

title = {Clinico-demographic profile and outcome of acute pediatric hydrocarbon poisoning in South India},

author = {Anil Kumar Vuppala and Rama Krishna Nelakurthi and Shalini Akunuri and Ahlaam Arif and M. Aleemuddin Naveed},

url = {https://www.publichealthtoxicology.com/pdf-189940-111867?filename=Clinico_demographic.pdf},

doi = {10.18332/pht/189940},

issn = {2732-8929},

year  = {2024},

date = {2024-06-28},

urldate = {2024-06-28},

journal = {Public Health Toxicology},

volume = {4},

issue = {2},

pages = {1-6},

abstract = {Introduction: Acute hydrocarbon poisoning in children is an important cause of morbidity and mortality in developing countries. This study aimed to understand clinico-demographic profile and outcome of acute hydrocarbon poisoning in children belonging to low-middle economy families from South India. Methods:

A prospective observational study was conducted over 18 months from January 2022 to June 2023 in a private medical college from South India for children between 1 month and 18 years of age admitted with a history of acute hydrocarbon poisoning. Results: Out of 1568 admissions, 29 children had acute hydrocarbon poisoning. Median age was 2.6 years (range: 6 months-15year). The majority (58.6%) belonged to toddler age group. The male-to-female ratio was 1.6:1. Most (48.3%) cases were seen during summer. All poisonings were accidental and occurred via the ingestion route. Paint thinner (75.9%) and mosquito repellent (20.7%) were the most common agents implicated. Vomiting (69%), cough (24.1%), and respiratory distress (20.7%) were the predominant symptoms noted. Chest radiograph was abnormal in 10% of patients. Respiratory support was provided in 44% of patients. 70% of patients were discharged within 24 hours. There was no mortality. Conclusions: Acute hydrocarbon poisoning is a preventable cause of mortality and morbidity in children. The majority of cases occur in the toddler age group and are accidental. Most patients improve with simple conservative measures. Following unit protocols for the management avoids unnecessary investigations, and medications and promotes early discharge.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2024,

title = {Correlation of comorbidities and outcome in CAD patients: a novel TANGENTS score study},

author = {Mohammed Abdul Hannan Hazari and Kailas Laxman Rao and Bachi Tazneem and Sana Rafeeq and Syeda Rahmath Fatima and Summaya Jabeen and Kankan Kavya},

url = {https://mmsl.cz/corproof.php?tartkey=mms-000000-0435},

doi = {10.31482/mmsl.2024.009},

issn = {0372-7025},

year  = {2024},

date = {2024-06-18},

urldate = {2024-06-18},

journal = {Military Medical Science Letters},

volume = {93},

issue = {3},

pages = {XX-XX},

publisher = {Faculty of Military Health Sciences, University of Defence, Czech Republic},

abstract = {Background: Cardiovascular diseases (CVD) are influenced by various established risk factors, including the ratio of neutrophils to lymphocytes and platelets, which has been shown to be an independent risk factor for acute coronary syndrome (ACS). This study aims to create a new scoring system called TANGENTS that utilizes discrete parameters of risk factors and diagnostic parameters to analyze the outcome of coronary artery disease (CAD) patients with comorbidities, particularly Type 2 diabetes mellitus (T2DM).

Methods: We included 151 subjects (mean age 57.92 ± 23.86) who presented with ST-elevation and ST-depression on admission and were treated with heparin, clopidogrel, aspirin, and atorvastatin while undergoing all the necessary diagnostic tests. We obtained ECG and complete blood picture (CBP) results on admission, day 3, and day of discharge.

Results: ST-depression on ECG on day-1 was 0.35 and decreased to 0.30 on the day of discharge. ST-elevation on ECG on day-1 was -0.89 and decreased to -0.16 on the day of discharge. The average neutrophil-to-lymphocyte ratio (NPR) was 0.49, which was high in 144 patients. The mean NLR value was 5.52, indicating a correlation between high NLR values and the magnitude of current injury on admission.

Conclusion: The TANGENTS scoring system can be used as an early evaluation tool for CAD patients with comorbidities to manage and prevent further complications. It allows for progressive differentiation in the severity of clinical outcomes using all the parameters of the score, and the parameters creating the TANGENTS score scale were found to be reliable.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {A comparative study of either sex on visual reaction time},

author = {Humera Ayesha and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/a-comparative-study-of-either-sex-on-visiual-reaction-time/Mzk1NTA=/?is=1&b1=&k=},

issn = {2249-555X},

year  = {2024},

date = {2024-05-31},

journal = {Indian Journal of Applied Research},

volume = {14},

issue = {5},

pages = {1-2},

abstract = {Human reaction time denotes time taken by an individual to react to an external stimulus. The response obtained while

measuring human reaction time is voluntary response obtained after training and is specific in nature. The purpose of this study was to find out whether the reaction time was faster for green light stimuli or red-light stimuli. And to compare the visual human reaction times in males and females. Reaction is a purposeful voluntary response to stimulus. The time interval between presentation of stimulus and getting a appropriate voluntary motor response is a reaction time1.it measures for alertness and processing speed of CNS which gets influenced with age, gender, physical activity and IQ of a subject. Different studies were conducted worldwide among different individuals have reported the prevalence of stress ranging from 27% to 73%. Different stress acts as an acute stressor which affects cognitive functions. It is found that the stress elicits elevated activity in the hypothalamic-pituitary-adrenal axis and increased release of cortisol. The study was planned to investigate gender difference. Choice reaction time (CRT) was used to evaluate the cognitive performance of digital reaction time. Randomly occurring visual tasks was presented. The readings was analyzed},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Severe cigarette smoking caused prostate cancer and bony metastasis - a case study},

author = {Humera Ayesha and Syed Abbas Mujtaba},

url = {https://rjpn.org/ijcspub/viewpaperforall.php?paper=IJCSP24B1253},

issn = {2250-1770},

year  = {2024},

date = {2024-05-31},

journal = {International Journal of Current Science},

volume = {14},

issue = {2},

pages = {223-226},

abstract = {Severe cigarette smoking is considered to be one of the largest addictions and has been a major health problem. Around 8 million people die due to smoking9. Estimated that 1 in 4 adult men in the world smoke tobacco which has carcinogenic agents like Polycyclic aromatic hydrocarbons (PAH)3 causing gene mutations4 such as PTEN5, PREX2, AGO2 which weakens immune system, DNA damage finally resulting in cellular proliferation and developing cancer. Along the side of lung cancer in smokers we observed that prostate11 cancer is also being diagnosed in the worldwide population among men, early deaths occurred due to bony metastasis2 for not quitting smoking. The associated gene mutation between smoking and prostate cancer can be PTEN through AKT activation pathway. severe cigarette smoking also contributes to heart disease and various other cancers like throat and gastric etc.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Haqqani_2024,

title = {Novel stop‑gain TSC2 gene mutation in an Indian child of tuberous sclerosis complex},

author = {Ruhi Haqqani and Sidra Rana and Nayeem Sadath Haneef and Omar Farooq and Vadlamudi Raghavendra Rao},

url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265763/pdf/IDOJ-15-657.pdf},

doi = {10.4103/idoj.idoj_469_23},

isbn = {2229-5178},

year  = {2024},

date = {2024-05-20},

urldate = {2024-05-20},

journal = {Indian Dermatology Online Journal},

volume = {15},

number = {pmid39050051},

issue = {4},

pages = {657-659},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ayesha_2024,

title = {Emission of electromagnetic rays from mobile phones cause dysfunction of thyroid gland},

author = {Humera Ayesha and Shaikh Mahmood},

url = {https://www.ijsr.net/getabstract.php?paperid=ES24515081512},

doi = {10.21275/es24515081512},

issn = {2319-7064},

year  = {2024},

date = {2024-05-05},

urldate = {2024-05-05},

journal = {International Journal of Science and Research (IJSR)},

volume = {13},

issue = {5},

pages = {1151-1153},

publisher = {International Journal of Science and Research},

abstract = {During the past decade, there is a dramatic increase in wireless communication system particularly the mobile phones (cell phones) which are low power single channel two ways radios that emit signals through electromagnetic waves. As most of the physiological functions in our body is regulated by electric currents and the electromagnetic fields (EMF) emitted from the mobile phones may affect the physiological processes and associated health effects like sleep disorders, headaches, etc. When we discuss about the endocrine system the most exposed vital endocrine glands when compared to pineal, pituitary, adrenal which can get affected by the electromagnetic fields is thyroid gland, an important endocrine glands that control our body metabolism which is located in front of the neck and release hormones into the bloodstream. It secretes thyroxine (T4), triiodothyronine (T3) and calcitonin. To synthesize thyroid hormones thyroid gland needs Iodine, too little or too much iodine can affect the level of hormones and its release. Role of thyroid hormones is to control metabolism, body temperature, breathing, heart rate, brain development, mental activity, digestion, fertility, etc. This study shows a higher TSH level (Hypothyroidism) with low T4 in mobile phone users. It may be concluded that there can be deleterious effects of mobile phones through electromagnetic rays on Hypothalamo-Pituitary-Thyroid axis (HPT).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khoraishi_2024,

title = {Case report of Gradenigo syndrome},

author = {Faezah Khoraishi and Sakeena Hussain and Summaya Fatima and Imtiaz Ahmed Khan and Syeda Ayesha},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/case-report-of-gradenigo-syndrome_April_2024_5682851671_2013202.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2024},

date = {2024-04-30},

urldate = {2024-04-30},

journal = {International Journal of Scientific Research},

volume = {13},

issue = {4},

pages = {13-14},

abstract = {Background: Back in 1900's, Gradenigo reported a series of patients with suppurative otitis media presenting with headache, unilateral eye pain and restricted lateral gaze of ipsilateeral side. Chronic ear infections spreading to temporal bone extends to the petrous apex which is the hub for 5th and 6th cranial nerves. We present one such case of a 19 year old male with history of chronic otiti Case: s media who presented with acute onset of retro-orbital pain, headache and diplopia. patient with chronic ear discharge who present with crani Conclusion: al nerve involvement, one must suspect intracranial extension. Management with appropriate antibiotics can change the course of the condition. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2024c,

title = {Cervicomedullary compression in achondroplasia: a feared complication and an unforeseen risk factor of posterior circulation stroke},

author = {Reshma Sultana Shaik and Sandhya Manorenj and Sravan Kumar Marupaka},

url = {https://journals.lww.com/neur/fulltext/2024/72020/cervicomedullary_compression_in_achondroplasia__a.31.aspx},

doi = {10.4103/ni.ni_537_21},

issn = {0028-3886},

year  = {2024},

date = {2024-04-30},

urldate = {2024-04-30},

journal = {Neurology India},

volume = {72},

number = {pmid38691484},

issue = {2},

pages = {399-402},

abstract = {Achondroplasia is an autosomal dominant disorder with defect in the ossification of the cartilage of long bones. Many bony abnormalities constitute its clinical features, with craniovertebral junction (CVJ) anomalies being one of most common issues which need to be addressed at the earliest. CVJ anomalies in individuals may cause neurovascular compression, which may warrant an early surgery to prevent catastrophic complications. Posterior circulation strokes secondary to CVJ anomalies are well known. We hereby present an unusual case of posterior circulation stroke in an achondroplastic dwarf who presented to our tertiary care centre. Prospective case study. The present case adds to the existing literature about one of the preventable causes of fatal posterior circulation strokes in the young. A high index of suspicion for neurovascular compression at the foramen magnum and early initiation of treatment in achondroplastic young individuals may have gratifying results.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2024b,

title = {Acute Necrotizing Encephalopathy of Childhood (ANEC) in a patient with dengue and leptospirosis},

author = {Reshma Sultana Shaik and Sandhya Manorenj and Sravan Kumar Marupaka},

url = {https://journals.lww.com/neur/fulltext/2024/72020/acute_necrotizing_encephalopathy_of_childhood.43.aspx},

doi = {10.4103/ni.ni_984_21},

issn = {0028-3886},

year  = {2024},

date = {2024-04-30},

urldate = {2024-04-30},

journal = {Neurology India},

volume = {72},

number = {pmid38691496},

issue = {2},

pages = {433-434},

abstract = {None},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024c,

title = {A neurologist’s perspective of approach to falls in the elderly},

author = {Sandhya Manorenj and Reshma Sultana Shaik},

url = {https://journals.lww.com/aomd/fulltext/2024/07010/a_neurologist_s_perspective_of_approach_to_falls.2.aspx},

doi = {10.4103/aomd.aomd_56_22},

issn = {2590-3446},

year  = {2024},

date = {2024-04-29},

urldate = {2024-04-29},

journal = {Annals of Movement Disorders},

volume = {7},

issue = {1},

pages = {3-12},

abstract = {Falls constitute an important public health problem that impact the quality of life of an individual. Falls contribute to disability, especially among older adults and elderly individuals. Recurrent fallers are those who fall one or more times per year. The purpose of this article is to provide a detailed systemic qualitative review of the recent definition of falls, their mechanism, risk factors, classification; falls in neurodegenerative disorders; and their approach and management. Sources of literature were drawn from peer-reviewed original and systematic review articles published until January 2024 in the PubMed database using the following key words: falls, elderly, definition, management, etiology, neurodegenerative diseases, epilepsy and fall, dementia and fall, and prevention and diagnostic tests for postural instability and falls. This review summarizes the current understanding of falls and provides a pragmatic and clinically focused approach to their management. Falls are usually multifactorial. Neurodegenerative disorders such as cognitive decline and parkinsonism lead to increased risk of falling. There are several tools to assess the risk of early falls. A multidisciplinary approach is needed in the management of falls. The main goal is encouraging physical activity, home hazard modification, management of postural hypotension, and underlying neurodegenerative diseases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hyder_2024,

title = {Effect of smartphone usage during night time on sleep patterns of young adults: A cross-sectional observational study},

author = {Safa Hyder and Sudhir Shankar Mane and Mohammed Abdul Hannan Hazari and Mehnaaz Sameera Arifuddin},

url = {https://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2024&month=April&volume=18&issue=4&page=CC01&id=19291},

doi = {10.7860/jcdr/2024/66874.19291},

issn = {0973-709X},

year  = {2024},

date = {2024-04-01},

urldate = {2024-01-01},

journal = {Journal of Clinical and Diagnostic Research},

volume = {18},

issue = {4},

pages = {CC01-CC06},

publisher = {JCDR Research and Publications},

abstract = {Introduction: Excessive smartphone usage among adolescents and young adults has been consistently linked to poor sleep. Moreover, smartphone overuse has been associated with daytime tiredness, longer sleeps latency, and reduced sleep duration. The significance of addressing poor sleep among adolescents and young adults is underscored by recent research linking it to adverse physical and psychological health outcomes, such as mood disturbances, impaired cognitive function, and increased risk incidence of hypertension and diabetes.

Aim: To evaluate the effects of smartphone usage on sleep quality among individuals using Pittsburgh Sleep Quality Index (PSQI) and hypnogram data.

Materials and Methods: In this cross-sectional observational study, sleep patterns were assessed using the PSQI questionnaire and Prime Nap sleep tracker app (version 1.1.4). The study was conducted by Deccan College of Medical Sciences, Hyderabad, Telangana, India. The data was collected in the form of a hypnogram and the study was conducted in the participants’ homes (under domicile conditions) in the city of Hyderabad, Telangana, India from March 2020 to April 2020. A total of 60 participants (both male and female) in the age group of 15-25 years were recruited and divided into two groups: one comprising 30 individuals with regular prolonged exposure to smartphone screens at night, and the other consisting of 30 individuals who experienced minimal or no smartphone exposure once they prepared to sleep. Descriptive statistics were applied to the collected data using Microsoft Excel and IBM Statistical Package for Social Sciences (SPSS) for Windows version 25.0.

Results: Adding up the average scores of the seven factors gives a global PSQI score from 0 to 21, with 0-4 indicating good sleep and 5-21 indicating poor sleep. Among those who used smartphones regularly at night time, 20 participants (66.67%) had PSQI score >5 and poor sleep quality, 24 participants (80%) had prolonged sleep latency, 18 participants (60%) had poor sleep duration, 27 participants (90%) had sleep disturbances, and 22 participants (73.33%) had increased daytime dysfunction. Hypnogram abnormalities were seen in >15 participants (50%) of subjects.

Conclusion: The prevalence of smartphone addiction is widely acknowledged in the medical literature, highlighting the need for its assessment, especially among adolescents and young adults. The study reveals that poor sleeping habits among participants were attributable either to a lack of awareness or neglect. By recognising the importance of adequate sleep, improvement in the quality of daily activities can be made by reducing daily screen time, consequently alleviating both physical and mental stress. Furthermore, the findings have implications for individuals whose work involves prolonged exposure to computer screens, especially during night time.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}