@article{Manorenj_2025,

title = {Diaphragmatic myoclonus effectively treated with lacosamide: a very rare phenomenon of belly dancer syndrome},

author = {Sandhya Manorenj and Bushra Naaz and Manju Madhavan},

url = {https://journals.lww.com/neur/fulltext/2025/01000/diaphragmatic_myoclonus_effectively_treated_with.26.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00458},

issn = {0028-3886},

year  = {2025},

date = {2025-02-07},

urldate = {2025-02-07},

journal = {Neurology India},

volume = {73},

issue = {1},

pages = {149-151},

abstract = {Diaphragmatic myoclonus, also called diaphragmatic flutter, has characteristic abdominal movements resembling those of a belly dancer; hence, it is also called belly dancer syndrome (BDS). BDS is characterized by high-frequency involuntary diaphragmatic contractions. BDS can occur due to a lesion anywhere in the pathway for diaphragmatic control, from the motor cortex to the neural supply to the diaphragm. Here we report a 21-year-old girl who presented with acute-onset abdominal movements of 5 days duration. Clinical examination showed abdominal jerky movements with preserved awareness. Electroencephalograms (EEG) showed polyspike wave discharges consistent with cortical myoclonus. These abdominal myoclonic jerks disappeared dramatically on treatment with lacosamide, a third-generation antiepileptic drug. There are few case reports of BDS in the literature with a cortical myoclonus origin instead of the widely described segmental myoclonus form. The case also highlights the efficacy of lacosamide in treating diaphragmatic myoclonus jerk in young adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2025b,

title = {Acquired hepatocerebral degeneration and accumulation of manganese},

author = {Sandhya Manorenj and Sravan Kumar Marupaka},

url = {https://journals.lww.com/annalsofian/fulltext/2025/01000/acquired_hepatocerebral_degeneration_and.17.aspx},

doi = {10.4103/aian.aian_633_24},

issn = {0972-2327},

year  = {2025},

date = {2025-01-02},

urldate = {2025-01-02},

journal = {Annals of Indian Academy of Neurology},

volume = {28},

issue = {1},

pages = {107-109},

abstract = {A 43-year-old man with chronic liver disease (CLD) due to alcoholism and hepatitis B virus (HBV) infection presented at the emergency department after experiencing a generalized tonic–clonic seizure and altered consciousness. He had been diagnosed with adult-onset epilepsy 3 years ago and was taking medication for seizure, which he had missed 2 days before. In addition, he was being treated with entecavir for the HBV infection.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024g,

title = {Efficacy and safety of tenecteplase versus alteplase in acute ischemic stroke: evidence from a South Indian cohort},

author = {Sandhya Manorenj and Maryam and Iqra Jahan and Syeda Noor Fatima and Yumna Fatima and Mir Wajahath Ali},

url = {https://rjn.com.ro/articles/2024.4/RJN_2024_4_Art-13.pdf},

doi = {10.37897/RJN.2024.4.13},

issn = {1843-8148},

year  = {2024},

date = {2024-12-26},

urldate = {2024-12-26},

journal = {Romanian Journal of Neurology},

volume = {23},

issue = {4},

pages = {403-409},

abstract = {Background. Acute ischemic stroke (AIS) requires efficient thrombolytic therapy to re-establish vascular permeability and mitigate tissue damage. Alteplase and tenecteplase are prominent tissue plasminogen activators (tPAs) employed in this clinical scenario. This study compares these two agents, focusing on their efficacy, safety profiles, time parameters, and rates of re-hospitalization.

Objectives. To compare the efficacy and safety of tenecteplase versus alteplase for treating acute ischemic stroke in South Indian patients: a prospective study.

Methods. At a single center, we conducted a prospective, observational, non-interventional study of patients receiving thrombolytics alteplase or tenecteplase from November 2023 to July 2024, which included patients within a 4.5-hour window of symptom onset. The principal outcome of this study is to evaluate early neurological improvement using the clinical assessment scales – the National Institutes of Health Stroke Scale (NIHSS) at baseline and 24 hours, and the Modified Rankin Scale (mRS) at admission and 3 months. The secondary outcomes include the door-to-needle time (DTN) and assessing the need for re-hospitalization. Data was scrutinized using a t-test and median interquartile range (IQR).

Results. The study enrolled 64 patients, 32 treated with alteplase and 32 with tenecteplase. Statistical significance was found for the efficacy of the drugs (NIHSS post-treatment p = 0.01 and mRS p = 0.002). The DTN and re-hospitalization were found to be non-significant.

Conclusion. Both alteplase and tenecteplase efficiently manage AIS, with tenecteplase demonstrating advantages in early neurological improvement, ease of administration, and cost-effectiveness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kulkarni_2024,

title = {Attitude of caregivers, psychiatrists, and nurses toward coercive measures: an observational, survey-based comparative study},

author = {Sneha Kulkarni and M. Uma Shankar and Ravi Kumar Dabbiru and Ramsubba Reddy and Sireesha Srinivasa Rao and Minhajzafar Nasirabadi},

url = {https://journals.lww.com/tjpy/fulltext/2024/10020/attitude_of_caregivers,_psychiatrists,_and_nurses.9.aspx},

doi = {10.4103/tjp.tjp_4_24},

issn = {2455-8559},

year  = {2024},

date = {2024-12-21},

urldate = {2024-12-21},

journal = {Telangana Journal of Psychiatry},

volume = {10},

issue = {2},

pages = {143-150},

abstract = {Objectives: The primary objective was to compare the attitude of health-care providers (psychiatrists and nursing staff) and caregivers.

Materials and Methods: This prospective, survey-based study used the Staff Attitude to Coercion Scale, Morisky Medication Adherence Rating Scale, Oslo Social Support Scale, and the Modified Overt Aggression Scale.

Results: Participants (326) included psychiatrists (32.51%), staff nurses (35.58%), and caregivers (31.90%). Health-care professionals scored higher in offense and safety subscale (psychiatrists 3.2 and 5.55; nurses 3.12 and 5.65) compared to caregivers (2.46 and 5.10). In coercion as treatment subscale, caregivers scored least (0.78) (psychiatrists 1.15, nurses 1.92). The difference in these subscales was statistically significant (P = 0.001). There was no significant influence of social support and level of education of caregivers on the use of physical restraint. Of 104 patients, 58.65% were brought with physical restraint. Treatment compliance (n = 85) in stabilized patients was 84.7%.

Conclusion: According to health-care providers, the use of coercion was offensive; coercion can be reduced by improving the resources and giving more personal time. All groups acknowledged that coercion infringes on patients’ human rights but supported its use when necessary for ensuring patient care and safety in the environment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2024d,

title = {A pseudo guillain barre syndrome (GBS) presentation of sjogren’s syndrome},

author = {Reshma Sultana Shaik and Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/11000/a_pseudo_guillain_barre_syndrome__gbs_.29.aspx},

doi = {10.4103/ni.ni_4_23},

issn = {0028-3886},

year  = {2024},

date = {2024-12-17},

urldate = {2024-12-17},

journal = {Neurology India},

volume = {72},

issue = {6},

pages = {1283-1284},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2024b,

title = {Seroprevalence of SARS-CoV-2 IgG antibodies in health care workers and the associated risk factors during the covid-19 pandemic period at a tertiary care heatlh center in South India},

author = {Sarwat Fatima and Ahmed Abdul Bari Hazari and Deepika Handa},

url = {https://pdf.ipinnovative.com/pdf/23488},

doi = {10.18231/j.ijmmtd.2024.056 },

issn = {2581-4753 },

year  = {2024},

date = {2024-12-12},

urldate = {2024-12-12},

journal = {IP International Journal of Medical Microbiology and Tropical Diseases},

volume = {10},

issue = {4},

pages = {329-336},

abstract = {Background: Most of the published studies across the globe so far have demonstrated a highly variable seroprevalence rate of SARS-CoV-2 IgG antibodies in health care workers [HCW’s] during the pandemic period. Multiple risk factors were studied that influenced the seropositivity. 

Aim & Objective: The primary aim of the study was to determine the seroprevalence of SARS-CoV-2 IgG in HCW’s in local settings during the pandemic period. The secondary objective was to categorize the HCW’s based on the history of symptoms of covid-19 and also to evaluate the relation between the various risk factors and seropositivity amongst the HCW’s.

Materials and Methods: A cross sectional prospective study was conducted on health care workers at a tertiary care hospital in Telangana state during the pandemic period between March to April 2021. Following enrollment and verbal consent from the participants descriptive data was collected using a validated questionnaire. SARS-CoV-2 IgG antibodies estimation was done using ELFA technology after obtaining IERB clearance.

Results: Of the 230 enrolled participants 141 [61.30%] fulfilled the inclusion criteria. The overall SARS-CoV-2 IgG seropositivity in the present study was 48 [34.04%]. Of the 72 [51.06%] symptomatic HCW’s, 19 [26.38%] were seropositive and of the 69 [48.93%] asymptomatic, 29 [42.02%] were seropositive. Among the various risk factors studied none were found to be significantly associated with seropositivity.

Conclusion: in the present study a greater number of asymptomatic HCW’s were found seropositive which could be due to several of the reasons discussed below one being silent transmission of the virus and demands further enquiry into the cause by improved research methodology.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Golla_2024,

title = {Impact of diabetes on clinical characteristics and angiographic findings in young adults with ST-elevation myocardial infarction: a cross-sectional study},

author = {Abhishek Golla and Mohammed Hidayathulla and Sowmya Chavala and Rajashekar Reddy Gurrala and Sayed Mohammed Hussain Bangi},

url = {https://www.jcdr.net/articles/PDF/20401/75961_CE[Ra1]_F(SHU)_QC(SD_OM)_PF1(AG_OM)_PFA(IS)_PN(IS).pdf},

doi = {10.7860/JCDR/2024/75961.20401},

isbn = {0973-709X},

year  = {2024},

date = {2024-12-01},

urldate = {2024-12-01},

journal = {Journal of Clinical and Diagnostic Research},

volume = {18},

issue = {12},

pages = {OC01-OC04},

abstract = {Introduction: The prevalence of diabetes among young patients with ST-Elevation Myocardial Infarction (STEMI) is increasing, but its impact on this population remains understudied. Limited data on diabetes in young patients with STEMI exist. The presence of diabetes among young patients experiencing STEMI deserves special consideration, as it manifests with unique clinical patterns and can significantly impact their active lifestyle.

Aim: To determine the effect of diabetes and associated clinical characteristics in young patients with STEMI.

Materials and Methods: A cross-sectional study was conducted at a tertiary care centre in India between April 2018 and December 2019. Fifty-one STEMI patients aged below 40 years were enrolled and categorised into diabetic (n=23) and non diabetic (n=28) groups based on glycated haemoglobin (HbA1c) levels. Clinical characteristics, laboratory parameters and angiographic findings were compared between the groups. This study analysed continuous variables using Student’s t-test and Analysis of Variance (ANOVA) (expressed as mean±SD), and categorical variables using Chi-square or Fisher’s exact tests (shown as n, %). A p-value of < 0.05 was considered significant.

Results: The mean age was 35.6±3.4 years, with 80.4% male predominance. Diabetic patients showed higher prevalence of dyslipidaemia (p-value=0.009), hypertension (p-value=0.043), and metabolic syndrome (p-value=0.002). They also exhibited significantly higher levels of total cholesterol, triglycerides and Low-Density Lipoprotein Cholesterol (LDL-C). Anterior Wall Myocardial Infarction (AWMI) was predominant in both groups (p-value=0.442). Single-Vessel Disease (SVD) was most common, but Triple-Vessel Disease (TVD) was observed exclusively in diabetic patients (p-value=0.198). The Left Anterior Descending (LAD) artery was the most involved vessel in both groups.

Conclusion: Compared to non diabetic patients, young STEMI patients with diabetes demonstrated a more adverse cardiovascular risk profile and lipid abnormalities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Electrolytes imbalance in management of electrical burns},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/article/electrolytes-imbalance-in-management-of-electrical-burns/NDExNjA=/?is=1&b1=&k=},

issn = {2249-555X},

year  = {2024},

date = {2024-11-30},

journal = {Indian Journal of Applied Research},

volume = {14},

issue = {11},

pages = {32-34},

abstract = {Aim of treatment is to achieve skin cover to prevent infection and to allow early mobilization. Electrical injuries are a

relatively uncommon. Adult electrical injuries usually occur as an occupational hazard, whereas children are primarily

injured accidentally. The spectrum of electrical injury is very broad, ranging from minimal injury to severe multi organ involvement, with both occult and delayed complications and death. This is a prospective study from OWAISI HOSPITAL & RESEARCH CENTRE, DECCAN COLLEGE OF MEDICAL SCIENCES, HYDERABAD. A total of 100 patients presenting from June 2023 to September 2024 were included. Patients were treated with surgical excision 21 (21.53 %), fasciotomy 16 (16.43 %), escharotomy 77 (77.62 %), and amputation 10 (10.21 %). In all patients debridement was performed. After follow-up, there was 6.64 % (6 patients) mortality. Minimal mortality may be due to less surface area involved or no visceral injury. Patients survived with morbidity due to amputation. Initial management of electrical burn is imperative to optimize function and minimize long-term scarring. However, further studies are required regarding flap repair and microsurgery to minimize the rate of amputation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Iron folic acid deficiency in pregnant women with cleft lip and palate deformities},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/article/iron-folic-acid-deficiency-in-pregnant-women-with-cleft-lip-and-palate-deformities/NjAxNzg=/?is=1&b1=4&k=1},

issn = {2277-8179},

year  = {2024},

date = {2024-11-30},

journal = {International Journal of Scientific Research},

volume = {13},

issue = {11},

pages = {82-84},

abstract = {The Orofacial clefts occur when the lips or the roof of the mouth do not fuse properly during the early weeks of pregnancy. There is strong evidence that periconceptional use of folic acid can prevent neural tube defects but its effect on oral clefts has generated debate. To identify factors associated with suboptimal periconceptional use of folic acid and its potential effect on oral clefts. The population-based infant cohort of the national Growing Up in Indian study, which consists of 10,134 9-month-old infants. Data collection comprised questionnaires conducted by interviewers with parents in parents' homes. Characteristics of mothers who did or did not take folic acid before and during pregnancy, as well as the effect of folic acid use on the prevalence of cleft lip and palate were recorded. The prevalence of cleft lip and palate was 1.92 (94% confidence interval [CI] = 1.21 to 2.88) per 500 9-month-olds. The odds ratio for cleft lip was 2.24-fold higher (92% CI = 1.11 to 8.10, P = 0.006) for infants of mothers who did not take folic acid during

the first 3 months of pregnancy, when compared with those who did have a folate intake during the first trimester. Folic acid use was suboptimal in 32.2% (94% CI = 32.2 to 35.1) of the sample. These findings support the hypothesis that taking folic acid may partially prevent cleft lip and palate. They are particularly relevant for GPs, because they are usually the first port of call for women before and during early pregnancy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiuddin_2024,

title = {Vasculopathy and posterior circulation stroke after measles in two children},

author = {Mohammed Fahad Mohiuddin and Sandhya Manorenj and Shalini Akunuri and Ahlaam Arif},

url = {https://journals.lww.com/neur/fulltext/9900/vasculopathy_and_posterior_circulation_stroke.5.aspx},

doi = {10.4103/neurol-india.neurol-india-d-24-00502},

issn = {1998-4022},

year  = {2024},

date = {2024-11-29},

urldate = {2024-11-01},

journal = {Neurology India},

publisher = {Medknow},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bushra_2024,

title = {Molecular basis of sepsis: A new insight into the role of mitochondrial DNA as a damage-associated molecular pattern},

author = {Bushra and Shaik Iqbal Ahmed and Safia Begum and Maaria and Mohammed Safwaan Habeeb and Tahmeen Jameel and Aleem Ahmed Khan},

url = {https://www.sciencedirect.com/science/article/abs/pii/S1567724924001259?via%3Dihub},

doi = {10.1016/j.mito.2024.101967},

issn = {1567-7249},

year  = {2024},

date = {2024-11-01},

urldate = {2024-11-01},

journal = {Mitochondrion},

volume = {79},

issue = {suppl},

pages = {101967},

publisher = {Elsevier BV},

abstract = {Sepsis remains a critical challenge in the field of medicine, claiming countless lives each year. Despite significant advances in medical science, the molecular mechanisms underlying sepsis pathogenesis remain elusive. Understanding molecular sequelae is gaining deeper insights into the roles played by various damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) in disease pathogenesis. Among the known DAMPs, circulating cell-free mitochondrial DNA (mtDNA) garners increasing attention as a key player in the immune response during sepsis and other diseases. Mounting evidence highlights numerous connections between circulating cell-free mtDNA and inflammation, a pivotal state of sepsis, characterized by heightened inflammatory activity. In this review, we aim to provide an overview of the molecular basis of sepsis, particularly emphasizing the role of circulating cell-free mtDNA as a DAMP. We discuss the mechanisms of mtDNA release, its interaction with pattern recognition receptors (PRRs), and the subsequent immunological responses that contribute to sepsis progression. Furthermore, we discuss the forms of cell-free mtDNA; detection techniques of circulating cell-free mtDNA in various biological fluids; and the diagnostic, prognostic, and therapeutic implications offering insights into the potential for innovative interventions in sepsis management.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Hemangiomas and vascular malformations},

author = {Margam Prabhakar and Paladugu Krishna Sahi and Nagulapally Sudershan Rao and Shaikh Mahmood },

url = {https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/article/hemangiomas-and-vascular-malformations/MzAyNzk=/?is=1},

issn = {2277-8160},

year  = {2024},

date = {2024-10-31},

journal = {Global Journal for Research Analysis},

volume = {13},

issue = {10},

pages = {85-86},

abstract = {Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specifc morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumor. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. This paper reviews current theory and practice in the etiology, diagnosis, and treatment of these more common vascular anomalies. Vascular malformations and hemangiomas can cause significant morbidity and even mortality in both children and adults. For a number of reasons, physicians often confuse these lesions. The nomenclature for classifying these lesions is often used interchangeably and inappropriately. Clinically significant malformations are uncommon, and patients with these malformations are rarely encountered in primary medical facilities, rendering most physicians inexperienced in providing optimal care. Radiologists may become involved in the care of these patients when imaging or imaging-guided therapy is requested; therefore, knowledge of the imaging and treatment of these patients is essential. This article reviews the clinical and imaging approaches to vascular malformations and hemangiomas used in the multidisciplinary clinic, stressing a multidisciplinary approach, a practical

categorization scheme, characteristic imaging findings, and commonly encountered clinical scenarios.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024e,

title = {Awake bruxism in a patient with advanced alzheimer’s disease: an epiphenomenon of anxiety or marker of advanced disease},

author = {Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/09000/awake_bruxism_in_a_patient_with_advanced.35.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00401},

issn = {0028-3886},

year  = {2024},

date = {2024-10-31},

urldate = {2024-10-31},

journal = {Neurology India},

volume = {72},

number = {pmid39428794},

issue = {5},

pages = {1103-1104},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Cefoxitin and oxacillin resistance conundrums},

author = {Grishma Vijaykumar Kulkarni},

url = {https://journalsajrm.com/index.php/SAJRM/article/view/395},

doi = {10.9734/sajrm/2024/v18i11395},

issn = {2582-1989},

year  = {2024},

date = {2024-10-29},

journal = {South Asian Journal of Research in Microbiology},

volume = {18},

issue = {11},

pages = {1-11},

abstract = {Recently, mecA negative Staphylococcus aureus strains with decreased susceptibility to oxacillin and cefoxitin have been sporadically reported worldwide. They are called as borderline oxacillin resistant Staphylococcus aureus (BORSA). Almost, more than 30% of such strains are often misinterpreted and reported as MRSA (methicillin resistant Staphylococcus aureus ) due to the hyperproduction of beta lactamase enzyme and other reasons which results in invitro reduced

susceptibility to oxacillin as well as cefoxitin. Similar phenomenon is quite common in other staphylococci micrococci and macrococci. In order to identify beta lactamase hyperproducing staphylococci and other gram positive cocci and to avoid fals e reporting as methicillin resistant, a one year prospective study was conducted in Deccan college of medical sciences, Hyderabad, Telangana state, India in 2023. During one year duration, 5630 inpatient (IP) and 823 outpatient

(OPD) samples accounting for total 6453 cultures were received in the microbiology laboratory. Out of this,100 cultures of different samples showing pure growth of gram positive cocci suggestive of staphylococci, micrococci and other Gram positive cocci were included in the present study and tested against different antibiotics panel as per CLSI guidelines (Clinical and Laboratory Standards Institute.) Inclusion of amoxiclav disc to the antibiotics test panel as per recommendation by the special phenotypic methods for the detection of antibacterial resistance in the manual of clinical

microbiology was helpful to detect the beta lactamase hyperproducers (BHP) and helped to report correct identification of the organisms and curtailed the mismanagement of more than 95% of the patients. T herefore, I do recommend to differentiate borderline from true methicillin resistant strains to streamline the antibiotic therapy and hence further avoidance of selection of the resistant strains.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2024b,

title = {Effectiveness, utility, and economic analysis of three-drug treatment vs two-drug treatment in chronic obstructive pulmonary disease patients},

author = {Syed Aamir Ali and Subhranshu Panda and M. Aleemuddin Naveed},

url = {https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1126},

doi = {10.5005/jp-journals-11010-1126},

issn = {2277-9019},

year  = {2024},

date = {2024-09-30},

urldate = {2024-09-30},

journal = {Indian Journal of Respiratory Care},

volume = {13},

issue = {3},

pages = {146-151},

abstract = {Aim and background: Inhaled corticosteroids (ICS) and bronchodilators remain the mainstay of therapeutic modalities available for the management of chronic obstructive pulmonary disease (COPD). This study aimed to evaluate the effectiveness, utility, and economic analysis of a three-drug treatment vs a two-drug treatment in COPD patients. Materials and methods: An observation was conducted at a superspecialty hospital in Hyderabad. Out of the 115 patients recruited from the inpatient and outpatient wards of the Pulmonology Department, 55 patients received triple therapy containing ICS, long-acting β-agonists (LABA), and long-acting muscarinic antagonists (LAMA), whereas 60 patients were treated with dual therapy comprising ICS/LABA. Cost-effectiveness was assessed based on forced expiratory volume in 1 second (FEV1) (FEV1% predicted), St George's respiratory questionnaire (SGRQ) scores, SGRQ responder ratio, COPD assessment test (CAT) scores, and incremental cost-effectiveness ratio (ICER). Results: Results signified the enhanced potency of three-drug treatment vs two-drug treatment as proven by the improvement in average difference from initial values in (1) FEV1% predicted value of 4.36 [95% confidence interval (CI) (2.9–5.82)], (2) SGRQ scores of −6.76 [95% CI (−2.14 to −11.38)], SGRQ responder ratio of 13.25 (3.72–47.24), CAT scores of −5.15 [95% CI (−9.87 to −0.43)] and ICER of 3522 [95% CI (14682 to −7638)]. Conclusion: Triple therapy comprising LABA, LAMA, and ICS can optimize lung function and improve clinical outcomes, leading to overall enhancement of well-being compared to LABA/ICS dual therapy in moderate to severe COPD patients. Clinical significance: Three-drug treatment comprising ICS/LABA/LAMA is an effective and cost-effective therapeutic approach for managing moderate and severe COPD compared to ICS/LABA dual therapy. This is evidenced by improvements in spirometry values (FEV1% predicted) and health-related quality of life (HRQoL).},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Basith_2024,

title = {Efficacy of Tru-cut biopsy of the cervical lymphnodes over FNAC for detecting MTB using CBNAAT histopathology and cultures},

author = {Mohammed Abdul Basith and M. Aleemuddin Naveed and Ashfaq Hasan and Fahad Abdullah Bin Breik and Syed Mahmood Ahmed and Shireen Adeeb Mujtaba Ali},

url = {https://journals.lww.com/jdyu/fulltext/2024/13030/efficacy_of_tru_cut_biopsy_of_the_cervical.11.aspx},

doi = {10.4103/jdrysruhs.jdrysruhs_32_24},

issn = {2950-5356},

year  = {2024},

date = {2024-09-27},

urldate = {2024-07-01},

journal = {Journal of Dr. YSR University of Health Sciences},

volume = {13},

issue = {3},

pages = {247–252},

publisher = {Wolters Kluwer - Medknow},

abstract = {Introduction: The present study was carried out to see the usefulness of Tru-cut biopsy over fine needle aspiration (FNA) in diagnoses of tuberculosis (TB) cervical lymphadenopathy and comparing their yields by performing ZN staining, culture, cytology, histopathology, and CBNAAT.

Observation and Results: It was found that the yield of Tru cut was significantly more in ZN staining and histopathology. Even though the yield was more in culture and CBNAAT also, it was not statistically significant. FNA is a popular method which is very widely used, but it has a low yield. From the results, it was inferred that for FNA, the positive rate was 27.6%, 38.4%, 67.7%, and 43% for the four modalities of ZN staining, CBNAAT, cytology, and acid-fast bacilli cultures, respectively. Comparatively, for Tru-cut biopsy, the positive rate was 36.9%, 46.2%, 92.3%, and 47.7%, respectively, in all four modalities. It was noticed that the highest value was recorded for histopathology, followed by culture and CBNAAT for Tru-cut biopsy procedures. Comparatively, FNA showed the highest negative rate for ZN staining and CBNAAT.

Conclusion: The present study also highlights the importance of Tru-cut biopsy over FNA. It is one of the emerging techniques which if used properly could offer a better yield. Further results and conclusions are discussed in the paper.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024f,

title = {Unilateral asymptomatic multiple cerebral microbleeds: a very rare radiological entity},

author = {Sandhya Manorenj and S. Sravan Kumar and Chillapuram Shashanka and Sravan Kumar Marupaka},

url = {https://journals.lww.com/annalsofian/fulltext/2024/27050/unilateral_asymptomatic_multiple_cerebral.18.aspx},

doi = {10.4103/aian.aian_383_24},

issn = {0972-2327},

year  = {2024},

date = {2024-09-06},

urldate = {2024-09-06},

journal = {Annals of Indian Academy of Neurology},

volume = {27},

number = {pmid39240195},

issue = {5},

pages = {573-575},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2024d,

title = {Basal cistern sparing pattern of subarachnoid hemorrhage: an imaging clue for SAH beyond aneurysm},

author = {Sandhya Manorenj},

url = {https://journals.lww.com/neur/fulltext/2024/07000/basal_cistern_sparing_pattern_of_subarachnoid.40.aspx},

doi = {10.4103/neurol-india.Neurol-India-D-23-00705},

issn = {0028-3886},

year  = {2024},

date = {2024-08-31},

urldate = {2024-08-31},

journal = {Neurology India},

volume = {72},

number = {pmid39216057},

issue = {4},

pages = {892-893},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sameera_2024,

title = {Study of correlation of morphometric and radiological parameters of hyoid bone In the population of Telangan},

author = {Syeda Sadia Sameera and Hajira Fatima and Zafar Sultana Abdul Saleem and Shaik Hussain Saheb},

url = {https://www.afjbs.com/uploads/paper/ab628f2e1eafc839b644aa846cf907a4.pdf},

doi = {10.48047/AFJBS.6.Si4.2024.6127-6133},

issn = {2663-2187},

year  = {2024},

date = {2024-08-15},

urldate = {2024-08-15},

journal = {African Journal of Biological Sciences},

volume = {6},

issue = {Si4},

pages = {6127-6133},

abstract = {Background: The hyoid bone in humans is anatomically positioned in the anterior, upper aspect of the neck and is typically horseshoe-shaped. This bone plays a vital role in forensic studies as an indicator for diagnosing asphyxia deaths due to hanging and strangulation. Since modern facilities have improved the accuracy of measurement and study, present work correlates the morphometric features from the dry cadaveric specimens, as well as scanned images from living hyoid. This will generate useful data for medicolegal and anthropometric uses. This study conducted to corelate the morphometric and radiological parameters of adult hyoid bone in the population of Telangana. Material and Methods: We conducted this study with 40 dried specimens of hyoid bones. We have measured the parameters using vernier caliper and correlated in living using CT scan. In present study we have recorded the parameters like, Length of right greater cornu, Length of left greater cornu, Anteroposterior distance at the middle of body of hyoid bone, Length of Hyoid bone. Results: All the morphometric parameters of hyoid bone corelate with the radiological parameters. There is no significant difference between the dry bone and CT scan measurements in case of length of body of hyoid bone where as there is significant difference between the other three parameters. Conclusion: The findings of this study may be helpful for anthropometry and medicolegal importance and the surgeries in this reason. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ashraf_2024,

title = {Study of testosterone levels in type II diabetes mellitus male patients in Telangana population},

author = {Syed Mustafa Ashraf and Syeda Asma Gulnaaz},

url = {https://academicmed.org/Uploads/Volume6Issue4/83.%20[3614.%20JAMP_Dr%20Makandar%20U.K]%20415-417.pdf},

doi = {10.47009/jamp.2024.6.4.83 },

issn = {2687-5365},

year  = {2024},

date = {2024-07-26},

urldate = {2024-07-26},

journal = {International Journal of Academic Medicine and Pharmacy},

volume = {6},

issue = {4},

pages = {405-407},

abstract = {Background: Type-II DM is a major health problem globally; it affects mainly the cardio-vascular system, including the lipid profile, and also impairs hormone pathways like insulin and sex hormones in males, leading to impotency. Materials and Methods: 195 (one hundred ninety-five) type II DMs of different age groups were studied and compared with 190 normal (controlled) groups. The blood investigation included FBS and PP. Blood urea, serum creatinine, Hbs.A1C, lipid profile, urine albumin, creatinine ratio, and serum testosterone were estimated by chemiluminescence immune assay and HbA1c by HPLC. Results: The BMI, age, HBSA1C, and serum testosterone level were compared with the control group, and the p value was highly insignificant (p<0.001). Conclusion: It is confirmed that type II DM patients have lower serum testosterone levels. Diabetes mellitus affects the vascularity of vital organs and impairs the normal functions of tests, leading to male

sterility. The present study helps physicians or endocrinologists treat such patients efficiently.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Yeshwanth_2024,

title = {Mitochondrial potential and Nd1 gene expression analysis in platelets for quality assessment},

author = {Asapanna Naga Sai Venkata Yeshwanth and Sara Jabeen and Aleem Ahmed Khan and Nusrath Fathima},

url = {https://www.scholasticopenaccess.org/SCMS/SCMS-02-0043.pdf},

year  = {2024},

date = {2024-07-16},

urldate = {2024-07-16},

journal = {Scholastic Medical Sciences},

volume = {2},

issue = {5},

pages = {1-4},

abstract = {Background: Platelets are the tiniest blood particles, and their shape shows how lively they are. They are largely concerned with hemostasis, or the process of starting blood coagulation. The diverceful activity of platelet and molecules released from platelet storage granules are both necessary for these various activities. Initiating homeostasis, an inflammatory response, and an immune response at the site of injury during the acute phase

of wound healing, as well as encouraging angiogenesis and tissue regeneration during the repair phase, is examples of how these platelet activities interact synergistically. Therefore mitochondria function/quality plays various important roles in several disease processes. Several studies have demonstrated mitochondria dysfunction in various chronic degenerative diseases (ex: cardiovascular diseases; Type 2 diabetes). Hence, there is need for quality assessment platelet mitochondrial DNA for platelet functions. Materials and Methods: Platelets were incubated with Rhodamine 123 exclusive dye to assess the membrane potential. The cytotoxicity of platelets were assed at different dilution point using MTT assay. The activity of platelet mitochondrial (mtDNA) was assessed using ND1 gene. Results: The aggregation of platelets with Rhodamine dye indicates the active state of platelets. The decline of platelets with high concentration MTT assay was observed. The activity of mtDNA in platelets the ND1 gene and internal control 12s gene were expressed at same indicating the active

presence of mtDNA in platelets. Conclusion: The Rhodamine 123 stain with platelet indicates that the presence of mitochondrial membrane potential. The ND1 gene expression indicates the quality of mitochondrial DNA in platelets.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Vuppala_2024,

title = {Clinico-demographic profile and outcome of acute pediatric hydrocarbon poisoning in South India},

author = {Anil Kumar Vuppala and Rama Krishna Nelakurthi and Shalini Akunuri and Ahlaam Arif and M. Aleemuddin Naveed},

url = {https://www.publichealthtoxicology.com/pdf-189940-111867?filename=Clinico_demographic.pdf},

doi = {10.18332/pht/189940},

issn = {2732-8929},

year  = {2024},

date = {2024-06-28},

urldate = {2024-06-28},

journal = {Public Health Toxicology},

volume = {4},

issue = {2},

pages = {1-6},

abstract = {Introduction: Acute hydrocarbon poisoning in children is an important cause of morbidity and mortality in developing countries. This study aimed to understand clinico-demographic profile and outcome of acute hydrocarbon poisoning in children belonging to low-middle economy families from South India. Methods:

A prospective observational study was conducted over 18 months from January 2022 to June 2023 in a private medical college from South India for children between 1 month and 18 years of age admitted with a history of acute hydrocarbon poisoning. Results: Out of 1568 admissions, 29 children had acute hydrocarbon poisoning. Median age was 2.6 years (range: 6 months-15year). The majority (58.6%) belonged to toddler age group. The male-to-female ratio was 1.6:1. Most (48.3%) cases were seen during summer. All poisonings were accidental and occurred via the ingestion route. Paint thinner (75.9%) and mosquito repellent (20.7%) were the most common agents implicated. Vomiting (69%), cough (24.1%), and respiratory distress (20.7%) were the predominant symptoms noted. Chest radiograph was abnormal in 10% of patients. Respiratory support was provided in 44% of patients. 70% of patients were discharged within 24 hours. There was no mortality. Conclusions: Acute hydrocarbon poisoning is a preventable cause of mortality and morbidity in children. The majority of cases occur in the toddler age group and are accidental. Most patients improve with simple conservative measures. Following unit protocols for the management avoids unnecessary investigations, and medications and promotes early discharge.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gulnaaz_2024,

title = {Comparative study of antioxidant vitamins and enzymes in alcoholic liver diseases in Telangana population},

author = {Syeda Asma Gulnaaz and Syed Mustafa Ashraf},

url = {https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article133.pdf},

doi = {10.5281/zenodo},

issn = {0975-1556},

year  = {2024},

date = {2024-06-26},

urldate = {2024-06-26},

journal = {International Journal of Pharmaceutical and Clinical Research},

volume = {16},

issue = {7},

pages = {811-814},

abstract = {Background: The liver is the largest site of metabolism in the body. It also provides the primary site for alcohol metabolism. It leads to oxidative damage due to alcohol, which causes a decrease in anti-oxidant enzymes and chemicals. Method: 60 alcoholic liver disease patients were compared with the same number of healthy (controlled) groups. Clinical and laboratory investigations were carried out using venous blood plasma vit. E levels by Baker Hatal method, ascorbic acid by the Teitz method, and SVD by the Beers-Seizer method. Results: The comparison of non-enzymatic oxidant parameters. Ascorbic acid, vitamin E, and the comparison of anti-oxidant enzymes SOD, GPX in both groups were statistically highly significant (p<0.00). Conclusion: The present study indicates that alcohol promotes oxidative stress, a major cause of alcohol toxicity in liver Vitamin E is a potential therapeutic agent for alcohol-induced oxidative damage in liver.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sarwath_2025,

title = {Navigating mortality and morbidity trends in geriatric patients post-surgical fixation of hip surgery},

author = {Sadia Sarwath and Fouzia Nikhath and Mohammed Siddique Mohiuddin and Adeeba Sana},

url = {https://www.sciencedirect.com/science/article/pii/S2773157X24001243},

doi = {https://doi.org/10.1016/j.jorep.2024.100429},

issn = {2773-157X},

year  = {2024},

date = {2024-06-24},

urldate = {2024-06-24},

journal = {Journal of Orthopaedic Reports},

volume = {4},

issue = {3},

pages = {100429},

abstract = {Introduction: Hip fractures in the elderly pose significant risks, with potentially life-threatening complications. This retrospective analysis examines post-surgery mortality factors, focusing on age, pre-existing medical conditions, and surgical delay, while considering demographic variables and comorbidities. Methods: Data from patients undergoing post-hip immobilization surgery were retrospectively collected from hospital records. A follow-up questionnaire was administered approximately one year post-surgery via telephone. Results: Among 52 patients with hip fractures, 23 were women and 29 were men. The study's mortality rate stood at 30.7 %. Analysis of chi-square statistics for males (1.3535) and females (0.244669) showed no sex-related mortality impact. However, a significant p-value from the t-test indicated better post-surgery daily activity performance in males than females. Conclusion: The intervention, timely surgery and educating elderly patients on surgery delay risks could substantially mitigate mortality rates. Incorporating these strategies into clinical practice may yield considerable benefits in hip fracture management. Thus, the outcome of this is reduced mortality rates and improved postoperative functional outcomes.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hazari_2024,

title = {Correlation of comorbidities and outcome in CAD patients: a novel TANGENTS score study},

author = {Mohammed Abdul Hannan Hazari and Kailas Laxman Rao and Bachi Tazneem and Sana Rafeeq and Syeda Rahmath Fatima and Summaya Jabeen and Kankan Kavya},

url = {https://mmsl.cz/corproof.php?tartkey=mms-000000-0435},

doi = {10.31482/mmsl.2024.009},

issn = {0372-7025},

year  = {2024},

date = {2024-06-18},

urldate = {2024-06-18},

journal = {Military Medical Science Letters},

volume = {93},

issue = {3},

pages = {XX-XX},

publisher = {Faculty of Military Health Sciences, University of Defence, Czech Republic},

abstract = {Background: Cardiovascular diseases (CVD) are influenced by various established risk factors, including the ratio of neutrophils to lymphocytes and platelets, which has been shown to be an independent risk factor for acute coronary syndrome (ACS). This study aims to create a new scoring system called TANGENTS that utilizes discrete parameters of risk factors and diagnostic parameters to analyze the outcome of coronary artery disease (CAD) patients with comorbidities, particularly Type 2 diabetes mellitus (T2DM).

Methods: We included 151 subjects (mean age 57.92 ± 23.86) who presented with ST-elevation and ST-depression on admission and were treated with heparin, clopidogrel, aspirin, and atorvastatin while undergoing all the necessary diagnostic tests. We obtained ECG and complete blood picture (CBP) results on admission, day 3, and day of discharge.

Results: ST-depression on ECG on day-1 was 0.35 and decreased to 0.30 on the day of discharge. ST-elevation on ECG on day-1 was -0.89 and decreased to -0.16 on the day of discharge. The average neutrophil-to-lymphocyte ratio (NPR) was 0.49, which was high in 144 patients. The mean NLR value was 5.52, indicating a correlation between high NLR values and the magnitude of current injury on admission.

Conclusion: The TANGENTS scoring system can be used as an early evaluation tool for CAD patients with comorbidities to manage and prevent further complications. It allows for progressive differentiation in the severity of clinical outcomes using all the parameters of the score, and the parameters creating the TANGENTS score scale were found to be reliable.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}