@article{Arifuddin_2023b,

title = {Effects of tuberculosis on genitourinary system},

author = {Mohammed Khaja Arifuddin and Syed Faiz Ahmed},

url = {https://www.jcdronline.org/paper.php?slug=effects-of-tuberculosis-on-genitourinary-system},

doi = {10.48047/jcdr.2023.14.12.265},

issn = {0975-3583},

year  = {2023},

date = {2023-12-31},

urldate = {2023-12-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {12},

pages = {2291-2299},

abstract = {Background: Genitourinary Tuberculosis (GUTB) is a common site of extrapulmonary tuberculosis. The disease involves the kidneys, ureters, bladder, or genital organs. Clinical symptoms develop 10 – 15 years after primary infection. Only one-quarter of patients with GUTB have a known history of TB and about half of these patients have chest radiography findings. The current study aimed to determine the effects of GUTB.

Methods: The included patients were successive cases with a diagnosis of genitourinary tuberculosis. A total of 62 cases were reported with the diagnosis of genitourinary tuberculosis. PCR for MTb was done in 37 cases. Radiological evaluation included chest X-ray, KUB in all cases, and intravenous urogram when serum creatinine was normal. FNAC was performed in cases with serosal masses. All patients received antitubercular drug therapy with 4 drugs (Rifampicin, Ethambutol, Isoniazid, and Pyrazinamide) for 2 months followed by 2 drugs (Rifampicin and Isoniazid) for 7 months.

Results: Positive AFB staining and positive MTb culture in urine were seen in 31.37% and 41.17% of cases, respectively, confirming the presence of Mycobacterium tuberculosis in some GUTB patients. Positive PCR for MTb in urine is present in 67.56% of cases (in a subset of 37 patients). MTb culture in pus is only observed in 4 out of 7 cases, suggesting its less frequent occurrence compared to other positive findings. Sterile urine is found in 78.95% of cases, and Radiological abnormalities (IVU/NCCT/MUCG) suggestive of GUTB was found in 46/57 (80.7%) cases. Bladder biopsy was positive in 12/25(48%) cases done. A comparison of urinary PCR with urine for AFB staining urine for MTb culture and bladder biopsy was done.

Conclusion: The urinary (PCR) stands out as the most sensitive indicator among all microbiological tests. When coupled with radiological abnormalities, it significantly expedites the diagnosis of genitourinary tuberculosis. Optimal treatment involves a combination of multidrug chemotherapy and judicious surgery, as necessary. It is highly advisable to make every effort to reconstruct the urinary tract due to the rewarding outcomes associated with this approach. However, in cases where tissue is infected and irreparably damaged, the most effective course of action is ablating the affected tissue.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jahangir_2023,

title = {Study of route of delivery and perinatal outcome in oligohydramnios},

author = {Juveria Jahangir and Anjum Kehkeshan and Summaiyah Yousuf and Yusra Siddiqui and Rana Siddiqui},

url = {https://www.academicmed.org/Uploads/Volume5Issue6/285.%20[2114.%20JAMP_Anjum]%201385-1387.pdf},

doi = {10.47009/jamp.2023.5.6.285},

issn = {2687-5365},

year  = {2023},

date = {2023-12-31},

journal = {International Journal of Academic Medicine and Pharmacy},

volume = {5},

issue = {6},

pages = {1385-1387},

abstract = {Background: To study neonatal outcome and appropriate route of delivery in oligohydramnios of AFI < 5 cm in women at or beyond 34 weeks gestation. Methods: In this prospective case control study of 50 women (study group) with oligohydramnios of AFI < 5 cm at or beyond 34 weeks of gestation was compared with 50 women (control group) with normal AFI > 5 cm and less than 25 at or beyond 34 weeks matched for age, parity, gestational age. Women with PROM, gestational age < 34 weeks and greater than 40 weeks, congenital anomaly, PIH, multiple gestations were excluded from this study. This study was done in antenatal and intrapartum period for neonatal outcome and appropriate route of delivery. Results: In our study we found that oligohydramnios was associated with increased rate of non-reassuring fetal heart rate (25% Vs 6%), cesarean delivery (50% Vs 10%), low birth weight (60% Vs 25%), FGR (17% Vs 5%) and admission to NICU (15% Vs 5%). There was no neonatal death in the study. Conclusion: Pregnancies with isolated oligohydramnios (AFI <5 cm) at or beyond 34 weeks are associated with increased incidence of fetal distress (non-reassuring fetal heart rate), caesarean delivery, and low birth weight. Induction of labor was associated with increased rate of caesarean section due to fetal distress. No appropriate route of delivery can be recommended for isolated oligohydramnios.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jahangir_2023b,

title = {Comparison between misoprostol and dinoprostone in inducing labor},

author = {Juveria Jahangir and Anjum Kehkashan and Yusra Siddiqui and Summaiyah Yousuf and Syeda Shaheera},

url = {https://www.academicmed.org/Uploads/Volume5Issue6/286.%20[2115.%20JAMP_Anjum]%201388-1391.pdf},

doi = {10.47009/jamp.2023.5.6.286},

issn = {2687-5365},

year  = {2023},

date = {2023-12-31},

journal = {International Journal of Academic Medicine and Pharmacy},

volume = {5},

issue = {6},

pages = {1388-1391},

abstract = {Background: The objective of this study was to evaluate safety and efficacy of labour inducing prostaglandins E1 and E2. We compared the obstetrical outcomes of intra-vaginal misoprostol (PGE1) and intra-cervical dinoprostone gel (PGE2) in our study. Materials and Methods: The study included 100 full term pregnant women of 19 to 30 years age group, with a cephalic presentation of single live fetus. Fifty women were included in each group (study and control). Women in study group were given 50 micrograms of Misoprostol intravaginal, while the control group received 0.5 mg of intracervical dinoprostone gel each. Key parameters studied in both groups were average time taken for start of labour, induction time at birth, duration of delivery, oxytocin requirement and delivery method. Conclusion: In comparison to dinoprostone, our study found misoprostol to be a better option in inducing labour for both the mother and the fetus, due to its efficacy, safety, and affordability.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Study to determine the common substances that caused deaths due to ingestion brought for autopsy in tertiary care hospital, Hyderabad, Telangana, India},

author = {Mohammed Abdul Mujeeb Siddiqui and Zahraa Mohammed Siddiqui and Azra Siddiqui and Katkuri Parvathi},

issn = {2393-915X},

year  = {2023},

date = {2023-12-31},

journal = {International Journal of Contemporary Medical Research},

volume = {10},

issue = {12},

pages = {L1-L5},

abstract = {Background: This study was conducted to know the common substances that caused deaths by ingestion, brought for autopsy to Osmania General Hospital, Hyderabad, Telangana State, India for a period three years. The cases of deaths due to poisoning were selected from the autopsies conducted and analyzed for the most commonly ingested substance.

Material and methods: The samples were collected for three consecutive years from January 2012 to December 2014.

The contents of the stomach were examined grossly and the samples were collected in three containers during autopsy

for each individual case. Portion of stomach and its contents, portions of liver, kidney, blood and body fluids were collected labeled and sent to the State Forensic Science Laboratory for analysis of unknown poison. The reports were analyzed. The data collected was arranged according to age, sex and substances detected.

Results: A total of 1196 cases of poisoning in three years were studied. Most of the deaths occurred, were due the ingestion of Organophosphates. It is the commonest insecticide used by farmers in fields. The common age group involved is between 21 years to 30 years ingesting organophosphates. In the deaths due to poisonings, men are predominantly involved compared to women.

Conclusion: In the study it was concluded that the ingestion of poisonous substance organophosphate is usually intentional and is used to commit suicide. In children it is mostly accidental. Poison can also be used as homicide to kill a

person.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Unnisa_2023,

title = {Effect of physical activity on glycated hemoglobin [HbA1c] in non-diabetic individuals},

author = {Arshiya Unnisa and Farah Bahmed and Farisa Khatoon and Mehnaaz Sameera Arifuddin and Nazia Uzma},

url = {https://journals.lww.com/jdyu/fulltext/2023/12030/effect_of_physical_activity_on_glycated_hemoglobin.15.aspx},

doi = {10.4103/jdrysruhs.jdrysruhs_24_22},

issn = {5555-6666},

year  = {2023},

date = {2023-12-27},

journal = {Journal of Dr. YSR University of Health Sciences},

volume = {12},

issue = {3},

pages = {285-290},

abstract = {Introduction: Physical inactivity is a rapidly evolving public health issue that contributes to a wide range of chronic diseases and health consequences, including obesity, diabetes, and cancer. In addition to improving a patient’s overall health, increased physical activity has been demonstrated to be beneficial in the management of chronic conditions. The purpose of this research is to discover if there is a link between physical activity intensity and HbA1c levels in non-diabetic adults and, if so, which type of physical activity has the most impact on glycemic control.

Material and Methods: There were 90 healthy non-diabetic individuals in the study. The International Physical Activity Questionnaire (IPAQ) score was calculated after each subject’s physical activity questionnaire was evaluated. Based on their IPAQ scores, the participants were split into three groups: low, moderate, and vigorous physical activity. A 3 mL blood sample was taken in a vacutainer to determine HbA1c levels. The data was produced in Microsoft Excel and analyzed using the statistical application SPSS 17.0.

Result: HbA1c values were statistically significant in the moderate-physical-activity group, while IPAQ showed a statistical difference between males and females in the vigorous-physical-activity group. In all three groups, IPAQ scores were significantly different but not in HbA1c levels. The HbA1c and IPAQ scores had a modest negative connection. The difference between males and females in our study was statistically insignificant. The body mass index (BMI) and HbA1c, as well as BMI and IPAQ, were found to have a positive linkage.

Conclusion: Physical activity, particularly moderate-to-vigorous activity, has a bigger influence on non-diabetic people’s glycemic regulation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mirza_2023,

title = {A case report-astasia abasia treated with faradic stimulation},

author = {Samia Mirza and Khan Mohammad Zeeshan Ali and Saad Mohiuddin and Minhajzafar Nasirabadi},

url = {https://www.tjima.org/journal/index.php/tjima/article/view/135/229},

doi = {10.52314/tjima.2023.v3i2.135},

year  = {2023},

date = {2023-12-22},

urldate = {2023-12-22},

journal = {Telangana Journal of IMA},

volume = {3},

issue = {2},

pages = {55-57},

abstract = {Conversion disorder presents with a wide variety of symptoms, one of the rarest presentations being Astasia-Abasia; where the individual loses their ability to stand or walk normally without any apparent anatomic or physiologic abnormality. psychosocial stressors  have  been  observed  to  closely  precede  the  onset  of  symptoms.  Management  of  conversion  disorders  centres  around  psychoeducation and psychotherapy but the response is slow and varied. This case report describes one such case of a 13-year-old female with Astasia-Abasia who was successfully treated with Faradic stimulation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nasirabadi_2023b,

title = {Charting a legacy of excellence and community empowerment:the odyssey of IMA Hyderabad city branch},

author = {Minhajzafar Nasirabadi and Srirang Abkari and Khan Mohammed Zeeshan Ali },

url = {https://www.tjima.org/journal/index.php/tjima/article/view/121/211},

doi = {10.52314/tjima.2023.v3i2.121},

year  = {2023},

date = {2023-12-22},

urldate = {2023-12-22},

journal = {Telangana Journal of IMA},

volume = {3},

issue = {2},

pages = {1-3},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2023d,

title = {Morphometric study of human brain ventricles by magnetic resonance imaging in Indian population: a retrospective study},

author = {Zafar Sultana Abdul Saleem and Farah Bahmed and Syeda Sadia Sameera and Sravan Kumar Marupaka and Habib Khan Gulab Khan Pathan},

url = {https://journals.lww.com/jdyu/fulltext/2023/12020/morphometric_study_of_human_brain_ventricles_by.15.aspx},

doi = {10.4103/jdrntruhs.jdrntruhs_210_22},

issn = {5555-6666},

year  = {2023},

date = {2023-12-01},

urldate = {2023-12-01},

journal = {Journal of Dr. YSR University of Health Sciences},

volume = {12},

issue = {2},

pages = {171-177},

abstract = {Introduction: Ventricular parameters are used to study hydrocephalus, schizophrenia, tumors, trauma, Alzheimers disease, gender, aging and atrophy associated with many neurological diseases as stroke and dementia, to assess loss of brain parenchyma. Normal reference values of brain ventricles obtained by MRI are necessary to create baseline data for interpreting pathological changes, planning surgery and determining presence and progress of some neurological disorders. Materials and Method: This is a retrospective, cross sectional and non-interventional study. we have studied 100 brain MRI digital images. Following parameters have been studied frontal horn width [FHW], transverse internal diameter of skull[TIDS-F] at same level, frontal horn ratio[FHR], frontal horn length on both sides [FHLR & FHLL], total length of lateral ventricle on both sides [LVLR & LVLL], posterior horn width [PHW], transverse internal diameter of skull at same level [TIDS-P], fourth ventricle width [FVW] and fourth ventricle anteroposterior distance [FVAP]. SPSS. version. 21 was used for statistical analysis. Results: There were 54 females and 46 males between age 20 years to above 60 years. Frontal horn width, posterior horn width and total inner diameter of skull at frontal and posterior level has shown significant gender differences with P value as 0.0034,0.0004,0.00013 and 0.0004 respectively. Frontal horn ratio, total length of right and left lateral ventricles and total inner diameter of skull has shown significant increase with age. Conclusion: The normal reference values of ventricles obtained from MRI are necessary to form baseline data, for interpreting pathological changes and planning surgeries.volumetric measurements will provide more information than linear measurements.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Karan_2023b,

title = {The effect of durative computer usage on intraocular pressure},

author = {Siddharth Karan and Sheetal Baldava and Rahel Afzal and Farheen Fatima and Saira Begum},

url = {https://www.ijlbpr.com/uploadfiles/29vol12issue4pp162-165.20231019052727.pdf},

issn = {2250-3137},

year  = {2023},

date = {2023-10-31},

urldate = {2023-10-31},

journal = {International Journal of Life Sciences, Biotechnology and Pharma Research},

volume = {12},

issue = {4},

pages = {162-165},

abstract = {Aim: To investigate the changes in the Intraocular pressure (IOP) in adults on prolonged computer usage. Methods:31 adult subjects working with computers for prolonged hours had their Intraocular pressure checked with Schiotz tonometer. Measurements were taken initially on every individual before computer usage and then following 3 hours of computer usage. Results: There was significant rise in the Intraocular pressure (Mean Increase of Intraocular pressure is 1.23mm of Hg) in most of the myopic subjects after 3 hours of continuous usage of computer. Conclusions: Prolonged computer usage could induce transient Intraocular pressure elevation. Mostly Intraocular pressure elevation is seen in myopic subjects whereas emmetropic subjects showed little or no elevation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ali_2023b,

title = {Association between Candida albicans and COVID-19 in complete denture wearers: An observational study},

author = {Mohd. Osman Ali and Babashankar Alva and Suresh Nagaral and Rohit Patil and Mohammad Ullah Khan and Durgesh

A. Tiwari},

url = {https://www.cureus.com/articles/200623-association-between-candida-albicans-and-covid-19-in-complete-denture-wearers-an-observational-study#!/},

doi = {10.7759/cureus.47777},

issn = {2168-8184},

year  = {2023},

date = {2023-10-27},

journal = {Cureus},

volume = {15},

issue = {10},

pages = {e47777},

abstract = {Introduction: The phenomenon of coronavirus disease 2019 (COVID-19)-related candidiasis is gaining increased attention and acknowledgment as an integral component of the severe consequences of COVID-19. The aim of the

present study was to assess the association between Candida albicans and COVID-19 in complete denture wearers.

Materials and methods: An observational study was conducted on 45 complete denture wearers, who were divided into three groups as follows: Group 1, 15 subjects with mild to moderate COVID-19 infection; Group 2, 15 subjects with severe COVID-19 infection; and Group 3, 15 subjects without COVID-19 infection. Mean colony forming units (CFU) were observed on agar plates containing Sabouraud dextrose in the salivary samples of the participants. Analysis of variance, followed by post-hoc analysis by Tukey’s test, was used to compare CFU between the groups. Pearson’s correlation coefficient was used to study the correlation between variables.

Results: The highest average colony-forming units of Candida albicans were observed in Group 2, followed by Group

1, compared to the control group, and a significant (p<0.001) difference was found. A weak positive correlation was found between the age of the patients and the duration of denture usage, as well as between age and the counts of Candida albicans in Groups 1 and 3. This correlation was more pronounced in Group 3. A strong positive correlation was observed in all groups between the Candida albicans count and the duration of denture usage by the patients.

Conclusion: The association between Candida albicans and denture wear was compounded by the presence of COVID-19. Consequently, the timely identification of Candida albicans infection in patients with COVID-19 is

important to establish more efficacious approaches for antifungal treatment and prophylactic interventions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Quadri_2023,

title = {A study of factors affecting and outcomes in difficult total knee arthroplasty},

author = {Saadullah Khan Quadri and Mohammed Akram and Mohammed Siddique Mohiuddin and Mohammed Abdul Bari and Mohammed Abid Hussain and Mohammed Firdouse and Asapanna Naga Sai Venkata Yeshwanth},

url = {https://healthcare-bulletin.co.uk/article/volume-13-issue-4-pages306-312-ra/},

doi = {10.5083/ejcm},

issn = {2042-4884},

year  = {2023},

date = {2023-10-20},

urldate = {2023-10-20},

journal = {European Journal of Cardiovascular Medicine},

volume = {13},

issue = {4},

pages = {306-312},

abstract = {Background: This prospective observational study was undertaken to look into the factors that affect the outcome of total knee arthroplasty and the short-term results of total knee replacements in complex knee pathologies. Methods: This prospective observational study was conducted between 2021 and 2023 at Owaisi Hospital and Research Centre, Hyderabad. A consecutive series of 12 total knee arthroplasties was performed on 12 patients at our institute using PFC Sigma endoprosthesis. The patients were assessed clinically and radiologically using the INSALL scoring system.  Results: The average pre-operative range of motion (flexion) was 45˚, with a highest of 120˚ and a lowest of 0˚. The average post-operative flexion was 102˚, with a highest of 130˚ and a lowest of 90˚. The average extension lag preoperatively was 18˚, and the average postoperative extension lag was less than 10˚. The average pre-operative knee score was 64.84, with the highest score of 91 and the lowest score of 40. The majority of the patients had a score in the range of 51–100. The average post-operative knee score was 136.84, with the highest score of 160 and the lowest score of 120. A majority of the patients had an improvement in score in the range of 101–150. At 6 months, follow-up relief was excellent in most patients; only 10 patients had anterior knee pain, and all the patients were able to walk more than 50 blocks post-operatively without any walking aid. Conclusion: Determining the factors resulting in a difficult knee helps in formulating an appropriate surgical approach, which results in a better functional outcome following total knee arthroplasty.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Iqubal_2023,

title = {Study of testosterone levels in type II diabetes mellitus male patients in Telangana population},

author = {Mohammed Asif Muzaffer Iqubal and Mohammed Mudassir Ali and Mohammed Muneer Ahmed and Juwairia Mohammed Fariduddin},

url = {https://ijpcr.com/volume15issue10/},

issn = {0975-1556},

year  = {2023},

date = {2023-10-19},

journal = {International Journal of Pharmaceutical and Clinical Research},

volume = {15},

issue = {10},

pages = {309-313},

abstract = {Background: Type-II DM affects millions of people in India and globally, but the association between serum testosterone levels (STL) and type-II DM is still unclear, but it impairs reproductive health and quality of life. Method: 95 (ninety-five) type II DM patients of different age groups were studied and compared with 90 normal (controlled) groups. The blood investigation included FBS, PP Blood sugar, Blood urea, serum creatinine, HBA1C, lipid profile, urine albumin, creatinine ratio, serum testosterone were estimated by chemiluminesience immune assay and HbA1c by HPLC. Results: The BMI, age, HBA1C, and serum testosterone level were compared with the control group, and the p value was highly insignificant (p<0.001). Conclusion: The present pragmatic study has confirmed that type II DM patients have significantly lower testosterone and higher sugar level was proved.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2023c,

title = {Knowledge, attitude and practices of reproductive health among adolescent girls in field practice area of tertiary care centre, Hyderabad},

author = {Mehaboobi Shaik and Sayeedunnisa Sarah and Moniza Maheen},

url = {http://www.ijlbpr.com/uploadfiles/135vol12issue3pp694-699.20230809043213.pdf},

issn = {2250-3137},

year  = {2023},

date = {2023-09-30},

urldate = {2023-09-30},

journal = {International Journal of Life Sciences, Biotechnology and Pharma Research},

volume = {12},

issue = {3},

pages = {694-699},

abstract = {Background: Adolescents form precious human resources in every country & constitute 18% of the total population in India.The majority of adolescents lack basic knowledge about puberty, growth during puberty, safe sex, and hygiene. Adolescence is a period of rapid physical growth, sexual and psychological changes. Aim: The aim of the study was to understand the knowledge, attitude regarding reproductive health and to assess the practices regarding reproductive health among school-going adolescent girls of 6th to 10th standard. Methods: It is a cross-sectional study carried out among school-going adolescent girls of standard 6 to 10 in the field practice area of a medical college in Hyderabad. The study duration was from February 2022 to January 2023. The data collection tool used for the study was a semi-structured questionnaire. The data was analysed by using SPSS 20 software. Results: Among the total of 904 participants 45.7% were scared during the first menstrual cycle. Dysmenorrhoea was most common in class IV socioeconomic status (53.7%).31.4% of study participants had occasional itching and 5.3% had continuous itching. About 10.6% of study participants consulted doctors during menstruation of which the majority of them belonged to 10 to 12 years (16.3%). 58.6% of study participants did household activities during menstruation of which the majority were studying 9th class (69.2%). Conclusion: The present study concluded that female adolescents had unsatisfactory knowledge, inadequate hygiene practices, and positive attitudes toward Reproductive Health.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shaik_2023d,

title = {Health problems in school going adolescent girls in field practice area of tertiary care centre},

author = {Mehaboobi Shaik and Moniza Maheen},

url = {http://www.ijlbpr.com/uploadfiles/123vol12issue3pp630-636.20230802064005.pdf},

issn = {2250-3137},

year  = {2023},

date = {2023-09-30},

urldate = {2023-09-30},

journal = {International Journal of Life Sciences, Biotechnology and Pharma Research},

volume = {12},

issue = {3},

pages = {630-636},

abstract = {Background: Adolescents form precious human resources in every country & constitute 18% of the total population in India. Adolescence is a period of rapid physical growth, sexual and psychological changes. The aim of the study is to assess the health problems and health issues in Adolescent girls. Their physical growths were also studied. Methods: It is a cross-sectional study carried out among school-going adolescent girls of standard 6 to 10 in the field practice area of a medical college in Hyderabad. The study duration was from February 2022 to January 2023. The data collection tool used for the study was a semi-structured questionnaire. The data was analysed by using SPSS 20 software. Results: Among the total of 904 participants 60.1% belong to the 13-15 years age group and the majority belonged to class II socioeconomic status i.e. 45.6%. Around 79.2% are having skin problems. Among them, 37.1% have hair fall problems and 25.6% have multiple problems. Girls with any episode of illness from the past 15 days show stomach pain at 22.9% and headache at 15.9%. Conclusion: Health problems were found during health check-ups, indicating the need for regular health services. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Deepthisri_2023,

title = {Role of parenteral iron sucrose in the treatment of iron-deficiency anemia in pregnant women of gestational age 20–34 weeks},

author = {Tamatam Deepthisri and N. Chaitanya and Rohin},

url = {https://journals.lww.com/mjhs/fulltext/2023/11030/role_of_parenteral_iron_sucrose_in_the_treatment.5.aspx},

doi = {10.4103/mjhs.mjhs_68_22},

issn = { 2321-7006},

year  = {2023},

date = {2023-09-30},

journal = {MRIMS Journal of Health Sciences},

volume = {11},

issue = {3},

pages = {196-200},

abstract = {Background: Anemia is responsible directly or indirectly for 40%–60% of maternal deaths from cardiac failure, hemorrhage, infection, and preeclampsia. It also increases perinatal mortality and morbidity rates consequent to preterm deliveries, intrauterine growth restriction, low iron stores, iron-deficiency anemia, and cognitive and affective dysfunction in the infant.

Objective: The objective of this study is to study the efficacy of intravenous iron sucrose in terms of hemoglobin rise and side effects.

Materials and Methods: Single-center, hospital-based comparative prospective study was conducted among 60 patients admitted with anemia in pregnancy with a hemoglobin concentration of 7.5–9 g/dl. Blood samples were sent for evaluation of hemoglobin, packed cell volume (PCV), and serum ferritin levels at baseline, at 4, and 8 weeks.

Results: Mean age was 29.08 ± 5.74 years. About 51.7% belonged to the middle social class. Most were gravida III (36.7%). About 46.7% had 20–24 weeks of gestations. Seventy-five percent had microcytic hypochromic anemia. Hemoglobin improved significantly (P < 0.05) from 8.76 ± 0.54 g% at baseline to 11.47 ± 0.85 g% at 4 weeks, and to 12.68 ± 1.04 g% at 8 weeks; PCV also improved significantly (P < 0.05) from 26.78 ± 3.11% to 34.64 ± 3.73% at 4 weeks and again improved to 42.50 ± 4.67% at 8 weeks; serum ferritin also improved significantly (P < 0.05) from 23.06 ± 7.96 μg/l to 28.86 ± 9.79 μg/l at 4 weeks and again improved to 36.31 ± 12.53 at 8 weeks after parenteral iron sucrose therapy. Only one pregnant woman complained of vomiting and only four women complained of pain at the site of injection after giving parenteral iron sucrose therapy. About 91.6% of the women had no complaints.

Conclusion: Parenteral iron sucrose therapy in pregnant women with a gestational age of 20–34 weeks with iron-deficiency anemia was found effective in improving the hemoglobin, PCV, and serum ferritin with negligible side effects.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2023d,

title = {Assessment of soluble thrombomodulin and soluble endoglin as endothelial dysfunction biomarkers in seriously ill surgical septic patients: correlation with organ dysfunction and disease severity},

author = {Mohammed Affan Osman Khan and Tarun Kumar Suvvari and Syed Asif Shah Harooni and Aleem Ahmed Khan and Syyeda Anees and Bushra},

url = {https://link.springer.com/article/10.1007/s00068-023-02369-8},

doi = {10.1007/s00068-023-02369-8},

issn = {1863-9933},

year  = {2023},

date = {2023-09-23},

urldate = {2023-09-01},

journal = {European Journal of Trauma and Emergency Surgery},

publisher = {Springer Science and Business Media LLC},

abstract = {Background: Sepsis, a complex condition characterized by dysregulated immune response and organ dysfunction, is a leading cause of mortality in ICU patients. Current diagnostic and prognostic approaches primarily rely on non-specific biomarkers and illness severity scores, despite early endothelial activation being a key feature of sepsis. This study aimed to evaluate the levels of soluble thrombomodulin and soluble endoglin in seriously ill surgical septic patients and explore their association with organ dysfunction and disease severity.

Methodology: A case control study was conducted from March 2022 to November 2022, involving seriously ill septic surgical patients. Baseline clinical and laboratory data were collected within 24 h of admission to the Surgical Intensive Care Unit. This included information such as age, sex, hemodynamic parameters, blood chemistry, SOFA score, qSOFA score, and APACHE-II score. A proforma was filled out to record these details. The outcome of each patient was noted at the time of discharge.

Results: The study found significantly elevated levels of soluble thrombomodulin and soluble endoglin in seriously ill surgical septic patients. The RTqPCR analysis revealed a positive correlation between soluble thrombomodulin and soluble endoglin levels with the qSOFA score, as well as, there was a positive association between RTqPCR soluble thrombomodulin and the SOFA score. These findings indicate a correlation between these biomarkers and organ dysfunction and disease severity.

Conclusion: The study concludes that elevated levels of soluble thrombomodulin and soluble endoglin can serve as endothelial biomarkers for early diagnosis and prognostication in seriously ill surgical septic patients.},

key = {pmid37741913},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sebastian_2023,

title = {Heart failure: Recent advances and breakthroughs},

author = {Sneha Annie Sebastian and Edzel Lorraine Co and Arun Mahtani and Inderbir Padda and Mahvish Anam and Swapna Susan Mathew and Ayesha Shahzadi and Maha Niazi and Shubhadarshini Pawar and Gurpreet Johal},

url = {https://www.sciencedirect.com/science/article/abs/pii/S0011502923001141?via%3Dihub},

doi = {10.1016/j.disamonth.2023.101634},

issn = {0011-5029},

year  = {2023},

date = {2023-09-12},

urldate = {2023-09-01},

journal = {Disease-a-Month},

pages = {101634},

publisher = {Elsevier BV},

abstract = {Heart failure (HF) is a common clinical condition encountered in various healthcare settings with a vast socioeconomic impact. Recent advancements in pharmacotherapy have led to the evolution of novel therapeutic agents with a decrease in hospitalization and mortality rates in HF with reduced left ventricular ejection fraction (HFrEF). Lately, the introduction of artificial intelligence (AI) to construct decision-making models for the early detection of HF has played a vital role in optimizing cardiovascular disease outcomes. In this review, we examine the newer therapies and evidence behind goal-directed medical therapy (GDMT) for managing HF. We also explore the application of AI and machine learning (ML) in HF, including early diagnosis and risk stratification for HFrEF.},

key = {pmid37704531},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Anis_2023b,

title = {Outbreak of severe myocarditis in England: havoc by a harmless virus},

author = {Heeba Anis and Akbar Basha Shaik and Angad Tiwari and Abel Alemayehu and Abubakar Nazir and Linda Atulinda and Magda Wojtara and Olivier Uwishema},

url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.1541},

doi = {10.1002/hsr2.1541},

issn = {2398-8835},

year  = {2023},

date = {2023-08-31},

urldate = {2023-08-01},

journal = {Health Science Reports},

volume = {6},

issue = {9},

pages = {e1541},

publisher = {Wiley},

abstract = {Background: The World Health Organization (WHO) has been alerted to a concerning upsurge of severe myocarditis, an inflammatory heart condition, in neonates within Wales and South West England. The myocarditis cases are being intricately associated with enterovirus infection, belonging to the Picornaviridae family. The concerned pathogen poses a significant global disease burden, with an estimated 10 to 15 million symptomatic cases occurring annually in the United States alone. Neonates are particularly vulnerable with children under the age of one accounting for approximately 40% of enterovirus infections. Material and Methods: A comprehensive literature search was conducted using various databases including ClinicalTrials, Google Scholar, PubMed, ScienceDirect, MEDLINE, and Ovid Resources. The search strategy included utilizing keywords such as “myocarditis,” “Randomized controlled trials (RCTs). Only articles written in English were considered, and selection criteria included relevance to the research objectives, reasonable sample sizes, and robust methodology. In addition to the identified articles, meta-analyses, animal models and studies, and references from the selected articles were also examined to ensure a comprehensive review of the literature. Results: Ten hospitalized neonates, reported in the United Kingdom (UK), with positive PCR tests were reported to have myocarditis, predominantly caused by coxsackieviruses. The current situation in the region has brought global attention. With this study, we hope to draw attention to the critical aspects of the illness and, more crucially, the present strategies required to control the disease outbreak in England. Discussion: Current European Society of Cardiology (ESC) recommendations for the treatment of acute heart failure apply. Emerging research supports the use of immunosuppressive medication in some circumstances. Patients are advised to avoid aerobic activities for several months after healing. Neonatal enterovirus infections can vary in how they respond to IVIG therapy. The majority of enterovirus infections are self-limited, require no special therapy, and only little supportive care is required. Conclusion: The recent elevation in numbers for reported severe myocarditis in neonates within Wales and South West England, linked to enterovirus infection, poses a significant public health concern. Myocarditis caused by enteroviruses, particularly Group B coxsackieviruses, is associated with significant mortality rates. Diagnosis is supported by non-invasive techniques and cardiac enzyme blood tests. Treatment modalities primarily involve a palliative approach.},

key = {pmid37662542},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2023b,

title = {Virovore: a breakthrough in virology},

author = {Qamar Sultana and Sumitaksha Banerjee and Vibhor Agrawal and Dattatreya Mukherjee and Ranjit Sah and Vikash Jaiswal},

url = {https://journals.sagepub.com/doi/10.1177/11786361231190333},

doi = {10.1177/11786361231190333},

issn = {1178-6361},

year  = {2023},

date = {2023-08-21},

urldate = {2023-08-21},

journal = {Microbiology Insights},

volume = {16},

publisher = {SAGE Publications},

key = {pmid37621408},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Manorenj_2023b,

title = {Diffusion restriction in bilateral thalami: beyond artery of percheron infarct},

author = {Sandhya Manorenj and Reshma Sultana Shaik and Sravan Kumar Marupaka and Tasneem Ara},

url = {https://journals.lww.com/neur/fulltext/2023/71040/diffusion_restriction_in_bilateral_thalami__beyond.22.aspx},

doi = {10.4103/0028-3886.383876},

issn = {0028-3886},

year  = {2023},

date = {2023-08-18},

urldate = {2023-08-18},

journal = {Neurology India},

volume = {71},

issue = {4},

pages = {754-759},

publisher = {Medknow},

abstract = {Background: Bilateral thalamic infarction, especially the medial thalamus, has been characteristically described in the artery of Percheron (AOP) affection. However, bilateral thalamic restriction has been described in many entities beyond the AOP infarction. Objective: Here we describe a case series (three cases) with infection as an etiology for bilateral thalamic lesions in the topographic distribution of the AOP from a tertiary care center in tropical India. Materials and Methods: Case series during a 1-year period collecting cases with bilateral thalamic diffusion restriction on MRI who did not have thalamic infarcts and their outcomes. Results: Bilateral thalamic lesion can occur in both bacterial and viral infections such as tuberculosis, dengue, and SARS-COV-2. Thus, we intend to add infections as one of the etiologies in the ever-expanding list of conditions that produce bilateral thalamic restriction. Conclusions: All the acute symmetric thalamic lesions are not always secondary to vascular insult. Accurate assessment and prompt diagnosis can prevent unnecessary delays in treatment. To our knowledge, this is the first case series in the literature that throws light on the bilateral thalamic lesions in the topographic distribution of the AOP secondary to infections in a tropical country like India.},

key = {pmid37635510},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2023,

title = {A comprehensive review on neuroendocrine neoplasms: Presentation, pathophysiology and management},

author = {Qamar Sultana and Jill Kar and Amogh Verma and Shreya Sanghvi and Nirja Kaka and Neil Patel and Yashendra Sethi and Hitesh Chopra and Mohammad Amjad Kamal and Nigel H. Greig},

url = {https://www.mdpi.com/2077-0383/12/15/5138},

doi = {10.3390/jcm12155138},

issn = {2077-0383},

year  = {2023},

date = {2023-08-05},

urldate = {2023-08-01},

journal = {Journal of Clinical Medicine},

volume = {12},

issue = {15},

pages = {5138},

publisher = {MDPI AG},

abstract = {Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with neuroendocrine differentiation that can arise from any organ. They account for 2% of all malignancies in the United States. A significant proportion of NEN patients experience endocrine imbalances consequent to increased amine or peptide hormone secretion, impacting their quality of life and prognosis. Over the last decade, pathologic categorization, diagnostic techniques and therapeutic choices for NENs—both well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs)—have appreciably evolved. Diagnosis of NEN mostly follows a suspicion from clinical features or incidental imaging findings. Hormonal or non-hormonal biomarkers (like serum serotonin, urine 5-HIAA, gastrin and VIP) and histology of a suspected NEN is, therefore, critical for both confirmation of the diagnosis and classification as an NET or NEC. Therapy for NENs has progressed recently based on a better molecular understanding, including the involvement of mTOR, VEGF and peptide receptor radionuclide therapy (PRRT), which add to the growing evidence supporting the possibility of treatment beyond complete resection. As the incidence of NENs is on the rise in the United States and several other countries, physicians are more likely to see these cases, and their better understanding may support earlier diagnosis and tailoring treatment to the patient. We have compiled clinically significant evidence for NENs, including relevant changes to clinical practice that have greatly updated our diagnostic and therapeutic approach for NEN patients.},

key = {pmid37568540},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khatoon_2023,

title = {A clinico-histopathological and etiological assessment of different cutaneous granulomatous lesions},

author = {Rubiya Khatoon and Venu Somanapally and Naushaba Tazeen},

url = {https://www.jcdronline.org/admin/Uploads/Files/64a958b5e136d9.71957212.pdf},

issn = {0975-3583},

year  = {2023},

date = {2023-07-31},

urldate = {2023-07-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {7},

pages = {446-449},

abstract = {Aim: This study was conducted with the aim to evaluate the frequency and patterns of different cutaneous granulomatous lesions with its clinico-histopathological correlation to reach etiological diagnosis. Materials and Methods: The present cross-sectional observational was conducted in the Department of Pathology, Mamata Academy of Medical Sciences, Hyderabad for the period of 1 year. This study enrolled 100 cases of skin biopsies after histopathological confirmation of granulomatous lesions. Results: 100 cases were studied in which male predominance was noted in 64 (64%) cases and females constituted 36 (36%) cases. Most of the patients were noted in age group of 21 to 31 years i.e 36 (36%) cases followed by 20 (20%) cases in 31 to 41years. 86% of cases were seen below 50 years of age in ourstudy. Leprosy remained the significant causative reason for infectious granulomatous dermatoses succeeded by tuberculosis of skin. Borderline tuberculoid leprosy was found to be predominant, constituting 24 (24%) cases followed by indeterminate type 22 (22%) cases and lepromatous leprosy 21 (21%) cases, tuberculoid leprosy 18 (18%) cases and 8 (8%) cases of borderline lepromatous leprosy.Lupus vulgaris constituted 2 cases (2%) and only 2 (2%) case of sarcoidosis was found. Conclusion: Leprosy was the most common cause of cutaneous granuloma followed by Tuberculosis,fungal infection and foreign body reaction. Among the cases of leprosy, borderline tuberculoid leprosy and tuberculoid leprosy were the commonest subtype. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Arifuddin_2023,

title = {Multisystem inflammatory syndrome in children (MIS-C) of Asian countries: a mini-literature review on its clinical characteristics and outcomes},

author = {Mehnaaz Sameera Arifuddin and Mohammed Abdul Hannan Hazari},

url = {https://esmed.org/MRA/mra/article/view/4070},

doi = {10.18103/mra.v11i7.2.4070},

issn = {2375-1924},

year  = {2023},

date = {2023-07-29},

urldate = {2023-07-29},

journal = {Medical Research Archives},

volume = {11},

issue = {7.2},

pages = {1-7},

abstract = {COVID-19 pandemic though has reached endemic levels in most of the countries, it has left an indelible mark on the healthcare systems across the world. One of the emerging challenges faced by physicians and researchers all around the world is the increased incidence of Multisystem inflammatory syndrome in children (MIS-C). Most of the research work conducted till date focusses on the pathophysiology, management and treatment of this syndrome. Multisystem inflammatory syndrome in children has been found to be a consequence of hyperactive immune system resulting from cytokine activation and release of immune complexes subsequent to COVID-19 infection. This condition is also associated with multisystem dysfunction which if not diagnosed early and not treated promptly, could result in an increased mortality among children. Most of the cases have been reported from European and American countries, but not many from Asia. 

This literature review provides for plausible reasons as to why the incidence of multisystem inflammatory syndrome in children has been less in Asian countries compared to the rest of the world. It also gives insights into the treatment protocols for multisystem inflammatory syndrome in children followed by hospitals in these countries and also highlights how different MIS-C is from Kawasaki disease in terms of clinical presentation since both these conditions share a common disease spectrum. This review also lists out the clinical features and treatment followed in such patients belonging to Asian countries.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gangannapalle_2023,

title = {Nanoparticle albumin‑bound paclitaxel and solvent-based paclitaxel as chemotherapy options for patients with advanced gastric cancer: a systematic review and meta-analysis},

author = {Mahesh Gangannapalle and Husna Shahnoor and Lubna Sattar and Talwinder K. Nagi and Marwah Al-Tekreeti and Muhammad Waqas Khan and Madiha D. Haseeb and Areeba Khan},

url = {https://www.cureus.com/articles/168559-nanoparticle-albuminbound-paclitaxel-and-solvent-based-paclitaxel-as-chemotherapy-options-for-patients-with-advanced-gastric-cancer-a-systematic-review-and-meta-analysis#!/authors},

doi = {10.7759/cureus.41711},

issn = {2168-8184},

year  = {2023},

date = {2023-07-11},

urldate = {2023-07-01},

journal = {Cureus},

volume = {15},

issue = {7},

pages = {e41711},

publisher = {Springer Science and Business Media LLC},

abstract = {The aim of this study is to assess and compare the effectiveness and safety of nanoparticle albumin-bound paclitaxel (nab-PTX) and solvent-based PTX (sb-PTX) as treatment options for advanced gastric cancer. This meta-analysis was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. We carried out a comprehensive search of PubMed, Google Scholar, and EMBASE from inception to June 15, 2023. The search strategy included the following keywords: "Nanoparticle albumin-bound paclitaxel," "solvent-based paclitaxel," and "advanced gastric cancer," along with their synonyms and medical subject heading (MeSH) terms. In this meta-analysis, the primary outcome was the comparison of overall survival and progression-free survival between the two groups. For safety purposes, we compared the risk of hematological and non-hematological events between the two groups. Four studies were included in this meta-analysis enrolling 1052 patients (483 received nb-PTX and 569 received sb-PTX). In terms of efficacy, nab-PTX showed favorable trends in overall survival and progression-free survival, despite no statistically significant differences being reported. The subgroup meta-analysis showed that nab-PTX seemed to have a better effect on peritoneal metastasis compared to sb-PTX. Regarding safety, the number of patients with neutropenia and leucopenia was significantly higher in the nab-PTX group compared to the sb-PTX group. However, the difference was statistically insignificant. Future research should focus on conducting more robust studies to further validate these findings and establish a stronger evidence base for the use of nab-PTX in this patient population.},

key = {pmid37575705},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2023,

title = {In vitro isolation and characterization of multipotent postnatal stem cells from human dental pulp: an approach for regeneration of neural crest tissue},

author = {Nikhat Fatima and Aleem Ahmed Khan and Sandeep Kumar Vishwakarma},

url = {https://journals.lww.com/jpbs/fulltext/2023/15002/in_vitro_isolation_and_characterization_of.61.aspx},

doi = {10.4103/jpbs.jpbs_232_23},

issn = {0976-4879},

year  = {2023},

date = {2023-07-11},

urldate = {2023-07-01},

journal = {Journal of Pharmacy and BioAllied Sciences},

volume = {15},

issue = {Suppl 2},

pages = {S1040-S1042},

publisher = {Medknow},

abstract = {Postnatal dental pulp tissues give the proper justification of the stem cell assimilation and characteristic of the multipotent of the stem cells. Researchers use an in vitro isolation process for clarifying the different stages of staining and cell division. Data collected from various sources helps in understanding how the stem cells help in tissue regeneration. It highlights the immunological phenotypes with the synthesis with cDNA for mentioning molecular immunology. Study also mentions the mitochondrial consistency to measure the potentiality regarding the immunology and the way it differs from 0 to 21 days. Researchers also mention the way for the future development by utilizing the key advantages and definite multipotent of the dental stem cells.},

key = {pmid37693979},

keywords = {},

pubstate = {published},

tppubtype = {article}

}