@article{Ali_2025b,

title = {Rare meets routine: a case of sessile serrated lesion presenting as acute appendicitis},

author = {Syed Mubid Ali and Mohammed Abdullah Masood and Naushaba Tazeen and Asiya Tabassum and Idrees Akhtar Afroze and Atiya Begum and Shireen Adeeb Mujtaba Ali},

url = {https://ijpo.co.in/archive/volume/12/issue/3/article/24927/pdf},

doi = {10.18231/j.ijpo.11098.1680662831},

issn = {2394-6784},

year  = {2025},

date = {2025-10-17},

urldate = {2025-10-17},

journal = {Indian Journal of Pathology and Oncology},

volume = {12},

issue = {3},

pages = {279-282},

abstract = {Sessile serrated lesions (SSLs) are rare premalignant neoplasms usually arising in the colon but can also occur in the appendix, where their presentation often mimics acute appendicitis. We report the case of a 68‑year‑old male who presented with right lower abdominal pain and imaging findings suggestive of acute appendicitis with appendicular mucocele. The patient underwent appendectomy, and histopathological examination of the resected specimen revealed a sessile serrated lesion with marked dysplasia, without evidence of adenocarcinoma. Appendiceal SSLs are seldom reported in literature and may be overlooked due to their nonspecific clinical and radiological features. As SSLs are important precursors of colorectal carcinoma via the serrated neoplasia pathway, meticulous histopathological evaluation is crucial for accurate diagnosis. Early recognition, surgical excision, and colonoscopic follow‑up can help prevent malignant transformation. This case adds to the limited literature on appendiceal SSLs and emphasizes the need for increased awareness and documentation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Akhtar_2025,

title = {Vulvar leiomyoma: an unusual entity at a rare anatomical site},

author = {Mohtashim Idrees Akhtar and Naushaba Tazeen and Idrees Akhtar Afroze and Atiya Begum},

url = {https://ijnrd.org/papers/IJNRD2504372.pdf},

doi = {10.56975/ijnrd.v10i4.305369 },

issn = {2456-4184},

year  = {2025},

date = {2025-04-30},

urldate = {2025-04-30},

journal = {International Journal of Novel Research and Development},

volume = {10},

issue = {4},

pages = {d432-d436},

abstract = {Vulvar leiomyoma is a rare soft tissue tumor, accounting for only 0.03% of all gynecological tumors, which often leads to misdiagnosis. Leiomyoma is a type of smooth muscle tumor that primarily occurs in the uterus and is commonly known as a fibroid. However, extrauterine fibroids are quite rare and can be found in various locations, including the vulva, vagina, ovaries, urinary bladder, urethra, round ligaments, uterosacral ligaments, inguinal canal, retroperitoneum, sinonasal cavities, and even the kidneys. Vulvar leiomyoma typically affects women of reproductive age and can mimic conditions such as Bartholin’s cyst or abscess. Histologically, vulvar leiomyomas generally exhibit spindle-shaped cells, though other variants, such as the epithelioid subtype, have also been reported. In this report, we present a case of vulvar leiomyoma that was misdiagnosed as a Bartholin’s cyst before surgery.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025c,

title = {Mesentric cyst with a twist},

author = { Juveria Fatima and Shaila Tasneem and Farha Naaz and Naushaba Tazeen and Idrees Akhtar Afroze and Syed Asif Shah Harooni},

url = {https://jmas.in/fulltext/154-1722832055.pdf?1755672275},

doi = {10.5455/jmas.214286},

issn = {2231-1696},

year  = {2025},

date = {2025-01-31},

urldate = {2025-01-31},

journal = {Journal of Medical and Allied Sciences},

volume = {15},

issue = {1},

pages = {88-91},

publisher = {Deccan College of Medical Sciences},

abstract = {With an incidence rate of 0.1-0.3% gastrointestinal stromal tumors (GIST) are rare to be found in extraintestinal locations known as extraintestinal GIST (EGIST). Mesenchymal in origin, they arise from interstitial cells of Cajal, a part of gastrointestinal autonomic nervous system (ANS). It is more common in males than females. GIST is mainly seen in stomach followed by small bowel, colon, rectum and esophagus. Incidence of EGIST is less than 1%. Patients with neurofibromatosis-1 has increased incidence of GIST. It can also present as Carney-Stratakis syndrome. GIST less than 2 cm is usually asymptomatic while GIST more than 2 cm presents with unexplained growth of abdomen, nausea, anemia, difficulty in swallowing, loss of appetite and weight loss. Herein we present a case of 31-yr old female, who presented with complaints of intermittent abdominal pain and was evaluated for infertility. Abdominal ultrasonography (USG) revealed cystic mass of mesentery. Computed tomography (CT) scan abdomen confirmed a cystic lesion with central necrosis arising from jejunal loops. Surgical excision of mesenteric cyst was performed and histopathological diagnosis of gastrointestinal tumor was given. Thus, high index of suspicion is required on part of pathologist to expect an EGIST mimicking as a mesenteric cyst.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mujeeb_2025,

title = {Cartilaginous metaplasia of thyroid nodule},

author = { Madeeha Mujeeb and Jasmeen Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze and Imtiyaz Ahmed Khan},

url = {https://jmas.in/fulltext/154-1723005195.pdf?1752816740},

doi = {10.5455/jmas.214579},

issn = {2231-1696},

year  = {2025},

date = {2025-01-31},

urldate = {2025-01-31},

journal = {Journal of Medical and Allied Sciences},

volume = {15},

issue = {1},

pages = {92-94},

publisher = {Deccan College of Medical Sciences},

abstract = {Adenomatous goiter is the most common form of thyroid disease. Although degenerative changes like fibrosis, calcification, cystic changes and hemorrhagic tissue are commonly found, cartilaginous metaplasia is an unusual phenomenon in the thyroid gland. Heterotopic cartilage formation is a very rare finding in both neoplastic and non-neoplastic lesions. Only 2 cases have been reported so far. Here we present a case of a 65-year-old female who presented with a midline swelling in her neck for 2 months associated with difficulty in swallowing. The lymph nodes were not palpable and there were no pressure symptoms. Ultrasonography was suggestive of thyromegaly with large goiterous change in left lobe and isthmus of thyroid. Fine Needle Aspiration Cytology (FNAC) revealed Bethesda Category I lesion. The patient underwent left hemi-thyroidectomy. Microscopy revealed encapsulated lesions composed of variable-sized follicles filled with colloid. Cystic areas lined by benign follicular cells showing foci of cartilage were also observed. Consistent with diagnosis of adenomatoid goiter with cartilaginous metaplasia. This case shows a rare histopathological change in the thyroid nodular lesions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Farzeen_2025,

title = {Exploring a rare entity: Myxoid liposarcoma on anterior abdominal wall},

author = { Mehrina Farzeen and Sumaiya Shireen and Naushaba Tazeen and Idrees Akhtar Afroze and Syed Asif Shah Harooni},

url = {https://jmas.in/?mno=215424},

doi = {10.5455/jmas.215424},

issn = {2231-1696},

year  = {2025},

date = {2025-01-31},

urldate = {2025-01-01},

journal = {Journal of Medical and Allied Sciences},

volume = {15},

issue = {1},

pages = {95-98},

publisher = {Deccan College of Medical Sciences},

abstract = {Myxoid liposarcoma is a soft tissue tumor. Out of all the malignant tumors, soft tissue tumors account for less than 1%, in which liposarcoma is the most common type of soft tissue tumor. The common site for liposarcoma is extremities and retroperitonium and on abdominal wall is exceptionally rare with only 22 cases reported so far. We report a case of 56 year old male patient presenting with anterior abdominal wall mass in left hypochondriac region of 6 months duration. There was no pain or discharge associated with it. On clinical examination, the mass was located on left upper quadrant of abdomen. Abdominal ultrasonography revealed well defined, hypoechoic, space occupying lesion. FNAC revealed scant fibroblast tissue. Trucut biopsy was advised. Radiological, clinical and cytological investigations were non- specific. An excision biopsy was performed and the sample was sent for histopathological examination. Gross examination revealed well circumscribed nodular myxoid mass, which was grey white in color. Microscopic examination revealed mesenchymal cells with myxoid rich stroma and cells show signet ring configuration. Pathological evaluation of surgical specimen is the gold standard for diagnosis. Complete excision with clear margin is the mainstay of treatment in view of its local recurrence. We report this case as myxoid liposarcomas are rarely seen in the clinic, here it has presented on an extremely unusual site, anterior abdominal wall.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025d,

title = {Renal cell carcinomas’ hidden challenge: sarcomatoid differentiation uncovered},

author = {Syeda Yousufa Husna Fatima and Hafeza Farha Syeda and Naushaba Tazeen and Idrees Akhtar Afroze and Mohammed Abdul Majid Adil},

url = {https://jmas.in/fulltext/154-1723478384.pdf?1755843299},

doi = {10.5455/jmas.215330},

issn = {2231-1696},

year  = {2025},

date = {2025-01-31},

urldate = {2025-01-31},

journal = {Journal of Medical and Allied Sciences},

volume = {15},

issue = {1},

pages = {99-102},

publisher = {Deccan College of Medical Sciences},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2025,

title = {Diagnostic and prognostic significance of platelet indices and platelet lymphocyte ratio in covid vs dengue: an observational study},

author = {Asiya Tabassum and T. S. Shamshuddeen and Idrees Akhtar Afroze},

url = {https://journals.lww.com/jdrntruhs/fulltext/2025/01000/diagnostic_and_prognostic_significance_of_platelet.8.aspx},

doi = {10.4103/jdrntruhs.jdrntruhs_170_22},

issn = {2950-5348},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Journal of Dr. NTR University of Health Sciences},

volume = {14},

issue = {1},

pages = {46-51},

abstract = {Background: Both SARS-CoV and dengue virus share the same symptoms in the early stages and at times causing misdiagnosis, coinfections are common creating difficulties for the health care workers. Aim: Efforts were made to utilize the hematology parameters, Mean platelet volume and Platelet lymphocyte ratio (PLR) in early segregation, diagnosis and predicting the severity and prognosis of the cases and to determine, if further investigations or referrals would be required. Material and Methods: Observational study was conducted with 100 confirmed cases of COVID-19 and dengue patients. Results: Patients with COVID-19 present with leucopenia or leucocytosis, with Lymphopenia as the most significant finding, Platelet counts were adequate but Mean platelet volume (MPV) is insignificant and increased levels of PLR are related with bad prognosis. In Dengue, the white blood cells (WBC) count shows progressive leucopenia with lymphocytic predominance with atypical lymphocytes, thrombocytopenia with increased MPV and decreased PLR help in early diagnosis of dengue infection. Conclusion: Complete blood count (CBC) is the most common and inexpensive test performed in patients and has capacity to segregate and diagnose Covid 19 and Dengue cases at an early stage so that isolation and prompt treatment can be started early, decreasing the lead time and help in combating the pandemic. PLR and MPV can be used to predict the prognosis and complications and have usefulness in monitoring treatment response. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Fatima_2025g,

title = {Whispers of the ovary: a pathological journey through lymphangioma},

author = {Juveria Fatima and Naushaba Tazeen and Asiya Tabassum and Idrees Akhtar Afroze},

url = {https://journals.lww.com/tjima/fulltext/2025/01000/whispers_of_the_ovary__a_pathological_journey.14.aspx},

doi = {10.4103/tjima.tjima_15_25},

isbn = {3050-6158},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Telangana Journal of IMA},

volume = {5},

issue = {1},

pages = {44-47},

abstract = {Lymphangioma of the ovary is an exceedingly rare benign tumor, characterized by the proliferation of lymphatic vessels. Typically presenting in childhood or early adulthood, these lesions can often be asymptomatic but may occasionally lead to abdominal pain, pelvic mass, or complications such as torsion or hemorrhage. Diagnosis is primarily achieved through imaging techniques such as ultrasound, computed tomography, or magnetic resonance imaging, which help differentiate lymphangiomas from other ovarian masses. Histopathological examination is essential for definitive diagnosis, revealing cystic spaces lined by the endothelial cells and a lymphatic-like structure. Management usually involves surgical intervention, with complete excision being the preferred treatment to prevent recurrence. Given the rarity of ovarian lymphangiomas, there is limited literature on the long-term outcomes; however, most cases report favorable prognoses following appropriate surgical resection. This abstract aims to summarize the clinical features, diagnostic approaches, and treatment options for ovarian lymphangioma while emphasizing the need for awareness of this rare entity among clinicians to facilitate timely diagnosis and intervention. Further studies are warranted to better understand the pathogenesis and optimal management strategies for this unusual tumor.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naaz_2024,

title = {Epidermoid cyst in uterine cervix–a rare and unusual location},

author = {Farha Naaz and Asfiya Fatima and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/epidermoid-cyst-in-uterine-cervix-a-rare-and-unusual-location_May_2024_1521776051_9602538.pdf},

doi = {10.36106/ijar},

issn = {2249-555X},

year  = {2024},

date = {2024-05-31},

urldate = {2024-05-31},

journal = {Indian Journal of Applied Research},

volume = {15},

issue = {5},

pages = {61-62},

abstract = {Cervical epidermoid cysts and uncommon benign cystic lesions were identied in a 50-year-old woman. The patient presented with heavy menstrual bleeding and lower abdominal pain, and after initial treatment with endometrial biopsy and hemostatic uterine curettage, a total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The gross examination of the specimen revealed a hypertrophied cervix with a cyst lled with grey-white substance, as well as a polypoidal mass in the fundus and intramural broids. Histopathological examination conrmed the diagnosis of a cervical epidermoid cyst as an incidental nding. Squamous metaplasia was conned to the cervical mucosa. The precise etiology remains unclear, but post-parturient implantation of vestigial embryonic tissue might be a contributing factor as there is no other associated etiology in this case. This case report emphasizes the importance of considering epidermoid cysts in the differential diagnosis of cervical masses and highlights the need for further research to better understand the formation and management of these rare cysts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2024,

title = {Ovarian hydatid cyst-a rare entity: a case report},

author = {Hafeza Syeda Farha Sultana and Samia Mohammed and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/ovarian-hydatid-cyst-a-rare-entity-a-case-report_May_2024_7615171205_7202728.pdf},

doi = {10.36106/ijar},

issn = {2249-555X},

year  = {2024},

date = {2024-05-31},

urldate = {2024-05-31},

journal = {Indian Journal of Applied Research},

volume = {14},

issue = {5},

pages = {66-67},

abstract = {Hydatid disease is a zoonosis caused by the transmission of the larval stage of Echinococcus granulosus (dog tapeworm) either by consuming contaminated food and water or due to hand to mouth transmission from infested animals or partially cooked meat. Humans are the accidental host. Hydatid cyst of ovary is an extremely rare presentation accounting for 0.2-1% of all cases. A 47-year-old woman presented to the surgery department of Owaisi Group of Hospitals (PEH) with a chief complaint of abdominal pain for 1 week. USG examination revealed bilateral simple ovarian cysts and CT scan Fndings showed bilateral complex ovarian cysts. Routine investigations were normal. Surgery was performed for suspected ovarian cyst. The cysts were extracted and sent for HPE which confrmed the diagnosis of hydatid ovarian cyst. The incidence of hydatid cyst in the female reproductive system is less than 0.5% of all cases. The clinician must have a high index of suspicion whenever cystic lesions of pelvis are found as any spillage while operating may lead to anaphylactic shock and recurrence. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kareem_2024,

title = {A case report on pituitary neuroendocrine tumor (PNET) with oncocytic change},

author = {Sana Munazza Kareem and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/indian-journal-of-applied-research-(IJAR)/fileview/a-case-report-on-pituitary-neuroendocrine-tumor-pitnet-with-oncocytic-change_May_2024_5817170215_4803207.pdf},

doi = {10.36106/ijar},

issn = {2249-555X},

year  = {2024},

date = {2024-05-31},

urldate = {2024-05-31},

journal = {Indian Journal of Applied Research},

volume = {14},

issue = {5},

pages = {83-84},

abstract = {Neuroendocrine tumors (NET) originate from the diffuse neuroendocrine system. These can arise in almost every organ of the body, although they are most commonly found in the gastrointestinal tract and respiratory system. The skull base and sellar region are extremely rare sites for neuroendocrine carcinoma. Intracranial originating is lower than 0.74 %. A 55year old male was admitted in the neurosurgery department of Owaisi Group of Hospitals (PEH) with chief complaint of severe headache for 15 days, associated with giddiness, nausea and left eye vision disturbance. MRI showed Pituitary macroadenoma. Surgery was performed and the excised specimen of Pituitary adenoma was sent for HPE which revealed that the lesion was a Neuroendocrine tumor. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khalid_2024,

title = {A hospital-based study of prostate biopsy results in Indian males },

author = {Mohd. Khalid and Mohammed Mustafa Khan and Qader Ahmed Jalily and Dinesh Eshwar Mummareddi and Saritha Sirangi and Sri N S Avinash Dande},

url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC11086797/pdf/JFMPC-13-984.pdf},

doi = {10.4103/jfmpc.jfmpc_1339_23 },

issn = {2249-4863},

year  = {2024},

date = {2024-03-31},

urldate = {2024-03-31},

journal = {Journal of Family Medicine and Primary Care},

volume = {13},

issue = {3},

pages = {984-989},

abstract = {Introduction: The prostate is a gland belonging to the male reproductive system. Aging results in the dysfunction of the prostate that may present as inflammation, enlargement, and cancer. Additionally, the diseases of the prostate including cancers are slow in progression, and therefore, it is difficult to diagnose them early. Hence, it is increasingly important for physicians to recommend histopathological examination of the prostate gland to identify, manage, and treat prostate cancers. This study was conducted to assess prostate diseases among biopsy specimen collected from patients with signs of prostate diseases.

Materials and methods: This prospective study was conducted in the Department of Pathology, Deccan College of Medical Sciences, Owaisi Hospital, Hyderabad, between June 2012 and September 2014. All gross specimens (n = 300) of the prostate such as the needle biopsies of the prostate, transurethral resection of the prostate (TURP) chips, and excised specimens of the prostate were included in the study. Histopathological examinations of the biopsies were performed for nuclear size, chromatin material, nucleoli, membrane thickness, irregularity, cytoplasmic granularity, staining, and cell border conspicuity. The biopsies were also assessed for lobule formation, secretions, polymorphonuclear leukocytes, lymphocytes, macrophages, connective tissue stromal cells, their arrangements, and acellular connective tissue material.

Results: Of 300 total prostatic biopsies performed, 56 (18.66%) were identified as inflammatory lesions of the prostate (prostatitis), 98 (32.66%) revealed benign prostatic lesions (benign prostatic hyperplasia (BPH)), 112 (37.33%) were identified as BPH with premalignant lesions, and 34 (11.33%) were revealed as malignant tumors of the prostate. Chronic prostatitis (67.85%) was the common inflammatory lesion. The majority (91.42%) revealed epithelial lesions compared to stromal lesions (08.58%). BPH was predominantly (28.00%) noticed among patients in the age group of 61-70 years. Prostatic intraepithelial neoplasia (PIN) was observed majorly (53.35%) in the age group of 61-70 years. Most of the prostatic cancers were identified as adenocarcinomas. However, three variants were also categorized as small cell carcinoma, signet ring cell carcinoma, and transitional cell carcinomas.

Conclusions: The results reveal that prostatic adenocarcinomas are predominant among the study population. Additionally, prostatic diseases including cancer are commonly noticed among people belonging to the age group of 61-70 years. More than one-third of patients showed BPH with premalignant lesions, and a majority of the study population showed evidence of chronic prostatitis.},

key = {pmid38736835},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mahmood_2025,

title = {Correlation between histopathological grades of oral squamous cell carcinoma and tobacco consumption a cross sectional assessment},

author = {Aiman Mahmood and Hafeza Syeda Farha Sultana and Idrees Akhtar Afroze},

url = {https://www.makhillpublications.co/files/published-files/mak-rjms/2024/4-147-151.pdf},

doi = {10.36478/makrjms.2024.4.147.151},

issn = {1815-9346},

year  = {2024},

date = {2024-01-06},

urldate = {2024-01-06},

journal = {Research Journal of Medical Sciences},

volume = {18},

issue = {4},

pages = {147-151},

abstract = {Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer associated with tobacco consumption. Histopathological grading provides insights into the aggressiveness and prognosis of OSCC. This study aims to explore the correlation between the histopathological grades of OSCC and the history and extent of tobacco consumption in patients. A cross‐sectional study was conducted with 200 participants diagnosed with OSCC. Histopathological grades were determined using standard criteria and were correlated with detailed tobacco consumption history, including duration, frequency and type. Statistical analyses were conducted to assess the relationship between the grades of OSCC and tobacco use patterns. The study found a statistically significant correlation between higher histopathological grades of OSCC and increased levels of tobacco consumption. A noticeable pattern of more severe carcinoma grades was evident among heavy and long‐term tobacco users. The results also highlighted specific histopathological characteristics that were more prevalent in association with certain types and patterns of tobacco use. The findings suggest a strong link between tobacco consumption and the severity of histopathological grades of OSCC. These results underscore the critical need for targeted tobacco cessation programs and early screening for OSCC, especially among populations with high tobacco use. Further research is recommended to explore the mechanisms underlying the relationship between tobacco‐induced carcinogenesis and OSCC progression.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2024,

title = {Assessment of HER2 amplification in breast carcinoma: a cross‐sectional study comparing IHC and Fish},

author = {Jasmeen Tabassum and Lubna Yasmeen and Idrees Akhtar Afroze},

url = {https://makhillpublications.co/files/published-files/mak-rjms/2024/113-117.pdf},

doi = {10.59218/makrjms.2024.3.113.117},

issn = {1815-9346},

year  = {2024},

date = {2024-01-03},

urldate = {2024-01-03},

journal = {Research Journal of Medical Sciences},

volume = {18},

pages = {113-117},

abstract = {This cross‐sectional study aims to compare the effectiveness of Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH) in assessing HER2 amplification in breast carcinoma, which is pivotal for treatment strategy and prognosis. The study encompassed 200 patients diagnosed with breast carcinoma. HER2 status was initially assessed using IHC. Cases with equivocal or positive IHC results were further evaluated using FISH to confirm HER2 gene amplification. Statistical analysis was conducted to determine the concordance and discordance between the two methods. The results demonstrated a certain percentage of cases showing HER2 amplification. Concordance rates between IHC and FISH were high, with some discordant results analyzed to understand the causes. The study provided detailed figures on the sensitivity, specificity and predictive values of IHC in comparison to FISH, discussing the implications of these findings in clinical practice. This study underscores the significance of a complementary diagnostic strategy combining both IHC and FISH for the reliable determination of HER2 status in breast carcinoma. The findings advocate for an integrated approach to enhance accuracy, improve treatment decisions and ultimately, patient outcomes in breast cancer care.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shireen_2024,

title = {Prevalence of high grade dysplasia in colorectal polyp cross sectional analysis in tertiary care hospital},

author = {Sumaiya Shireen and Sumayya Aijaz and Idrees Akhtar Afroze},

url = {https://makhillpublications.co/files/published-files/mak-rjms/2024/100-103.pdf},

doi = {10.59218/makrjms.2024.3.100.103},

isbn = {1815-9346},

year  = {2024},

date = {2024-01-02},

urldate = {2024-01-02},

journal = {Research Journal of Medical Sciences},

volume = {18},

issue = {3},

pages = {100-103},

abstract = {The incidence of colorectal cancer had been increasing globally, with high‐grade dysplasia in colorectal polyps recognized as a significant precursor to malignancy. This study aimed to determine the prevalence of high‐grade dysplasia among patients with colorectal polyps in a tertiary care hospital setting.A cross‐sectional study was conducted involving 300 patients who underwent colonoscopy and were diagnosed with colorectal polyps at a tertiary care hospital. The presence of high‐grade dysplasia was confirmed through histopathological examination. Data regarding patient demographics, polyp characteristics and histological findings were collected and analyzed. The study found that high‐grade dysplasia was present in a significant proportion of colorectal polyps, particularly among patients aged 50 years and older, with a prevalence of 30% compared to 13.3% in younger patients. The odds of high‐grade dysplasia were notably higher in polyps >10mm in size (OR = 2.3) and located in the colon (OR = 1.9). Gender did not show a significant association with the presence of high‐grade dysplasia. Additionally, while an increasing number of polyps showed a higher prevalence of high‐grade dysplasia, this association did not reach statistical significance. All findings were statistically analyzed to ascertain the strength and significance of these associations, with age, polyp size and location showing notable correlations with the occurrence of high‐grade dysplasia in colorectal polyps. This study provided valuable insights into the prevalence of high‐grade dysplasia in colorectal polyps in a tertiary hospital setting. The findings informed clinicians and health policymakers about the importance of screening and surveillance strategies in the early detection and prevention of colorectal cancer.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Naaz_2023,

title = {Clinico-pathological correlation of inflammatory dermatoses in a tertiary care hospital},

author = {Farha Naaz and Naushaba Tazeen and Mohammed Mustafa Khan and Idrees Akhtar Afroze and Khatija Shameem and Atiya Begum and Asiya Tabassum and Sobia Afreen},

url = {https://jcdronline.org/index.php/JCDR/article/view/4062/3938},

issn = {0975-3583},

year  = {2023},

date = {2023-12-06},

urldate = {2023-12-06},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {12},

pages = {2525-2534},

abstract = {Inflammatory dermatoses encompass a variety of histologic patterns that affect different segments of the skin. Skin is a complex organ having many functions. Epidermis with melanocytic system, dermis with adnexa and subcutis are its main components. Skin diseases are highly prevalent in developing countries, occur commonly amongst all age groups and range from simple inflammatory lesions to fatal neoplasms. As clinical presentation can be similar for various skin lesions, histopathological examination remains the gold standard for accurate diagnosis and serves as a guide to clinician for appropriate management. The objective of this study is to observe and analyze the spectrum of inflammatory dermatological lesions through Histopathological examination. Through this we try to find out the common skin lesions in an urban population, evaluate its correlation with age and gender, and correlate the clinical diagnosis and histopathological examination. Out of 50 skin biopsies studied, 31 were female and 19 were male. Age of the patients range from 11 to 70 years in which peak age was 21-30 years. Leprosy is the most common lesion in our study accounting for 16 out of 50 cases studied. Next common lesion was Psoriasis, accounting for 10 out of 50 cases studied. Out of these 50 cases, 44 cases correlated with clinical diagnosis and the rest of cases did not correlate with given clinical diagnosis. The present study emphasizes the role of histopathological examination as a valuable diagnostic tool to understand the pathology of inflammatory dermatoses and provides a significant insight into trend of inflammatory skin lesions in the specific sub-population of Hyderabad, Telangana, India.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023b,

title = {Role of Ag NOR staining in benign and malignant lesions of prostate at a tertiary hospital },

author = {Mohammed Ghouse Mohiddin and Mohammed Mustafa Khan and Mohammed Masooduddin and Asiya Tabassum},

url = {https://www.jcdronline.org/paper.php?slug=role-of-ag-nor-staining-in-benign-and-malignant-lesions-of-prostate-at-a-tertiary-hospital},

issn = {0975-3583},

year  = {2023},

date = {2023-08-31},

urldate = {2023-08-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {8},

pages = {2600-2608},

abstract = {Nucleolar organizing regions (NOR) can be located by staining with silver nitrate under prescribed conditions; the structures thus demonstrated termed as `AgNORs'. Nucleolar organizing regions (NOR) counts might be of helpful specifically in conditions where histological distinction of prostatic cancer is difficult. Present study was aimed to study role of AgNORs in differentiating benign from malignant lesions of prostate. Material and Methods:Present study was single-center, prospective, observational study, conducted in samples of prostatic biopsies. The diagnosis in all cases were made on H & E and subsequently taken up for study.All prostatic biopsies were stained by the modified AgNOR technique. All silver-stained structures, both intra and extra nucleolar were counted.Results: Based on the histopathological examination of prostatic biopsies, 87 were diagnosed as benign (BPH) and 13 cases were malignant (Carcinoma prostate). Maximum no. of cases of BPH are in the age group of 51 - 60 years (40.2 %) followed by 61-70 years (39.1 %). Majority cases of carcinoma prostate were from age group of 51 - 60 years (38.46 %). In the present study we have applied AgNOR staining procedure to histopathologically diagnosed cases of BPH and Ca prostate. In BPH showed a mean AgNOR count of 2.38 ± 0.31, while biopsies from carcinoma prostate had a mean AgNOR count of 5.39 ±0.408. In our study BPH constituted majority of the lesions (87% of cases). Among BPH lesions, BPH with prostatitis constituted (29 %) which obscures the AgNOR staining. Ca prostate constituted (13%). Conclusion: Prostatic disease is responsible for significant morbidity and mortality in men throughout the world. AgNOR is a simple, cost effective and easy stain to evaluate the proliferative activity of different prostatic lesions},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023d,

title = {Comparative analysis of cytological and molecular markers in breast lesions: a cross sectional study},

author = {Mohammed Ghouse Mohiddin and Mohammed Masooduddin and Habeebunnisa Tahniath and Rida Tariq},

url = {https://healthcare-bulletin.co.uk/article/comparative-analysis-of-cytological-and-molecular-markers-in-breast-lesions-a-cross-sectional-study-1068/},

doi = {10.5083/ejcm/2023},

issn = {2042-4884},

year  = {2023},

date = {2023-08-29},

urldate = {2023-08-29},

journal = {European Journal of Cardiovascular Medicine},

volume = {13},

issue = {3},

pages = {1421-1425 },

abstract = {Background: Breast lesions are a significant global health concern, often requiring invasive procedures for definite diagnosis. Cytological and molecular markers present alternative, potentially less intrusive diagnostic methodologies. This study aims to compare the effectiveness of cytological and molecular markers for the diagnosis of breast lesions. Methods: A cross-sectional study was performed on a cohort of 500 patients presenting with breast lesions, undergoing cytological evaluation (Fine-Needle Aspiration Cytology) and molecular marker testing (HER2/neu, ER, PR, and Ki-67). Concordance between the two methods was evaluated. Results: Both cytological and molecular marker evaluations showed significant diagnostic potential. There was substantial concordance between the two modalities. However, molecular markers exhibited a slightly higher diagnostic sensitivity and specificity, especially in the detection of pre-malignant and malignant lesions. Conclusion: Cytological and molecular markers each offer valuable, complementary diagnostic approaches. While cytology provides rapid, cost-effective results, molecular markers offer increased sensitivity and specificity. Their combined usage can help minimize invasive procedures and improve patient outcomes. Further research is recommended to refine the usage of these diagnostic tools.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khatoon_2023,

title = {A clinico-histopathological and etiological assessment of different cutaneous granulomatous lesions},

author = {Rubiya Khatoon and Venu Somanapally and Naushaba Tazeen},

url = {https://www.jcdronline.org/admin/Uploads/Files/64a958b5e136d9.71957212.pdf},

issn = {0975-3583},

year  = {2023},

date = {2023-07-31},

urldate = {2023-07-31},

journal = {Journal of Cardiovascular Disease Research},

volume = {14},

issue = {7},

pages = {446-449},

abstract = {Aim: This study was conducted with the aim to evaluate the frequency and patterns of different cutaneous granulomatous lesions with its clinico-histopathological correlation to reach etiological diagnosis. Materials and Methods: The present cross-sectional observational was conducted in the Department of Pathology, Mamata Academy of Medical Sciences, Hyderabad for the period of 1 year. This study enrolled 100 cases of skin biopsies after histopathological confirmation of granulomatous lesions. Results: 100 cases were studied in which male predominance was noted in 64 (64%) cases and females constituted 36 (36%) cases. Most of the patients were noted in age group of 21 to 31 years i.e 36 (36%) cases followed by 20 (20%) cases in 31 to 41years. 86% of cases were seen below 50 years of age in ourstudy. Leprosy remained the significant causative reason for infectious granulomatous dermatoses succeeded by tuberculosis of skin. Borderline tuberculoid leprosy was found to be predominant, constituting 24 (24%) cases followed by indeterminate type 22 (22%) cases and lepromatous leprosy 21 (21%) cases, tuberculoid leprosy 18 (18%) cases and 8 (8%) cases of borderline lepromatous leprosy.Lupus vulgaris constituted 2 cases (2%) and only 2 (2%) case of sarcoidosis was found. Conclusion: Leprosy was the most common cause of cutaneous granuloma followed by Tuberculosis,fungal infection and foreign body reaction. Among the cases of leprosy, borderline tuberculoid leprosy and tuberculoid leprosy were the commonest subtype. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023c,

title = {Frozen section evaluation and clinicopathological correlation of sentinel lymph nodes in breast carcinoma},

author = {Mohammed Ghouse Mohiddin and Asiya Tabassum and Maryam Fatima and T. S. Shamshuddeen},

url = {https://www.makhillpublications.co/files/published-files/mak-rjms/2023/3-302-306.pdf},

doi = {10.59218/makrjms.2023.302.306},

issn = {1815-9346},

year  = {2023},

date = {2023-07-03},

urldate = {2023-07-03},

journal = {Research Journal of Medical Sciences},

volume = {17},

issue = {3},

pages = {302-306},

abstract = {The evaluation of sentinel lymph nodes (SLNs) plays a crucial role in the management and prognosis of breast carcinoma. This study aimed to investigate the utility of frozen section evaluation in assessing SLNs and its clinicopathological correlation in breast carcinoma patients. A retrospective analysis was conducted on a cohort of breast carcinoma patients who underwent SLN biopsy and frozen section evaluation. The frozen sections were evaluated for the presence of metastatic deposits and the results were compared with the final histopathological examination of the SLNs. The utility of frozen section evaluation in assessing sentinel lymph nodes (SLNs) based on the final histopathology results. The table indicates a significant association between frozen section evaluation and final histopathology, highlighting the value of frozen section evaluation in assessing SLNs. The concordance between frozen section evaluation and the final histopathological examination of SLNs regarding the presence or absence of metastatic deposits. The significant association between frozen section evaluation and metastatic deposits suggests the reliability of frozen section evaluation in detecting metastasis in SLNs. The clinicopathological parameters associated with SLN involvement. The significant correlations observed between Tumor Size, Histological Grade, Hormone Receptor Status, Lymphovascular Invasion and SLN involvement emphasize the importance of these parameters in predicting SLN involvement in breast carcinoma patients. These findings contribute to clinical decision‐making and management strategies for patients with breast carcinoma. Frozen section evaluation of SLNs in breast carcinoma provides valuable intraoperative information for immediate decision‐making regarding axillary lymph node dissection. It demonstrates high accuracy in detecting metastatic involvement of SLNs. The clinicopathological correlation of frozen section results with various tumor characteristics helps in better understanding the disease progression and optimizing patient management. Further prospective studies are warranted to validate these findings and refine the clinical application of frozen section evaluation in breast carcinoma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Masooduddin_2023,

title = {A histopathological study of soft tissue lesions},

author = {Mohammed Masooduddin and Sobia Afreen},

url = {https://www.ijsr.net/archive/v12i3/SR23316192000.pdf},

issn = {2319-7064},

year  = {2023},

date = {2023-03-31},

urldate = {2023-03-31},

journal = {International Journal of Science and Research},

volume = {12},

issue = {3},

pages = {1248-1252},

abstract = {Background: Soft tissue is defined as a complex of non - epithelial extra - skeletal structures of the body exclusive of the reticulo - endothelial system glia and supportive tissue of the various parenchymal organs. Aims: To study the following features of soft tissue tumors according to age, sex incidence, Site - specific distribution, most common type and various spectrum of soft tissue tumor in both malignant and benign of soft tissue tumor. Material and Methods: The present cross - sectional study was conducted in the Department of Pathology during the period of September 2016 to September 2020. A total of 100 samples from patient with soft tissue tumors, including both benign and malignant tumors, were analyzed. Conclusion: The large majority of soft tissue tumors are benign, with a very high cure rate rafter surgical excision. Malignant mesenchymal neoplasms amount to less than 1% of the overall burden of malignant tumors but they are life threatening and may pose significant diagnostic and therapeutic challenge. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mohiddin_2023,

title = {A histopathological study in detecting lesions of oesophagus, stomach and duodenum by endoscopic biopsies in adults and children in a tertiary care hospital},

author = {Mohammed Ghouse Mohiddin and T. S. Shamshuddeen and Sobia Afreen and Mariyah Raheem},

url = {https://healthcare-bulletin.co.uk/article?article_id=786&download=true},

issn = {2042-4884},

year  = {2023},

date = {2023-02-28},

urldate = {2023-02-28},

journal = {European Journal of Cardiovascular Medicine},

volume = {13},

issue = {2},

pages = {1577-1585},

abstract = {Background: Since its introduction in 1968, the upper gastrointestinal flexible fibre optic endoscope has proven to be a significant advance in the diagnosis of gastrointestinal tract (GIT) abnormalities.With the advent of flexible endoscopy, there has been a noticeable increase in diagnostic procedures requiring visualisation and biopsy of the upper and lower GI tract. Objectives: To correlate clinical diagnosis with histopathological diagnosis in detecting neoplastic lesions. To correlate endoscopic diagnosis with histopathological diagnosis in detecting neoplastic lesions.Material & Methods Hospital based Observational Cross Sectional Study. Study area:  The present study was carried out on endoscopic biopsy specimens received in the Department of Pathology, at Princess Esra Hospital and Owaisi Hospital and Research Centre; Deccan College of Medical Sciences. Study Period: 1 year. Study population:  Endoscopically directed biopsies were taken from patients with severe upper gastrointestinal symptoms like heart burn, dyspepsia, dysphagia, pain abdomen, vomiting etc. Sample size: study consisted a total of 100 cases. Sampling method: Simple random method.Results: Out of the 100 cases studied, 12 cases were positive for malignancy on histopathology. Out of these 12 cases, 8 cases were diagnosed malignant both on clinical examination and histopathology. 88 cases were negative for malignancy on histopathology, of which 72 cases were negative on both clinical diagnosis and on histopathology. Sensitivity: 66.67 %, Specificity: 81.82 %. Positive predictive value: 33.33 % Negative predictive value: 94.74 %. Accuracy: 80 %, Chi-square test: P-value=0.0025; (The result is significant at P<0.05).Conclusion: Endoscopic procedure in addition with histopathological findings remains the mainstay of diagnostic modality. Our study showed better correlation of histopathological diagnosis with endoscopic findings in detecting lesions of upper GIT. However, endoscopic examination and histopathological study of suspected lesions should always go in parallel and neither of them should be a substitute for each other.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sudula_2022,

title = {MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma},

author = {Mrudula Sudula and Meda Tejaswi and Naushaba Tazeen and Tasneem Fathima},

url = {https://www.ijpo.co.in/journal-article-file/17932},

doi = {10.18231/j.ijpo.2022.082},

issn = {2394-6784},

year  = {2022},

date = {2022-12-14},

urldate = {2022-12-14},

journal = {Indian Journal of Pathology and Oncology},

volume = {9},

issue = {4},

pages = {342-346},

publisher = {IP Innovative Publication Pvt Ltd},

abstract = {Giant juvenile fibroadenoma is a rare variant of more common benign lesion, fibro adenoma observed in younger population. They present with rapidly enlarging single or multiple breast masses in one or both the breast. A 10-year-old pre-pubertal girl presented with large lump in left breast followed by right breast lump. FNAC was suggestive of fibroadenoma, and histopathology confirmed the diagnosis. To understand the genetic basis of common entity like fibroadenoma with a rare presentation in very young age, the tissue block was subjected to gene sequencing and identified MED 12 gene mutation. It leads us to the possibility of new treatment modalities of targeting the causative gene and thus sparing the patient from invasive 

procedures.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Raheem_2022b,

title = {Role of neutrophil-lymphocyte ratio as a predictive marker in the diagnosis of acute coronary syndrome},

author = {Mariyah Raheem and Asiya Tabassum and Atiya Begum},

url = {https://www.ijsr.net/getabstract.php?paperid=SR22728102305},

issn = {2319-7064},

year  = {2022},

date = {2022-08-31},

urldate = {2022-08-31},

journal = {International Journal of Science and Research},

volume = {11},

issue = {8},

pages = {257-261},

abstract = {Background: Acute Coronary Syndrome (ACS) is one of the prevalent conditions, responsible for fatal heart attack and heart failure & leading cause of mortality and morbidity worldwide. Aims and Objectives: To study NLR-Neutrophil Lymphocyte Ratio as a predictive marker in diagnosis of patients with ACS. Materials and Methods: A prospective study of 66 cases admitted in Princess Esra Hospital with diagnosis of ACS were studied, their CBC reports within 72hours of onset of symptoms were collected, NLR were analysed. After informed consent, 2ml of venous blood collected from antecubital vein under aseptic precautions in a K2 EDTA vacutainer. Samples were run on Sysmex XN550 automated 5part analyser and values of WBC differential count reconfirmed on Peripheral blood Smear. Results: Gender Distribution: Frequency Percentage Male 32 48.5 Female 34 51.5 Total 66 Discussion: In our study of 66 cases, there was slight femalepreponderance and majority of the females were of post-menopausal age group, 48.5%-males, 51.5%-females. Majority of patients had Neutrophilic leucocytosis with an elevated NLR. Most of patients fell in age group of 46-55years. P VALUE was calculated by applying Student T test and was found to be 0.00294. P value is statistically significant if P<0.05. C. Chen, et al, described NLR positively correlated with Myocardial damage. In a study by A. M. Shumailah, et al, NLR was found to be the strongest predictive marker for ACS, [p value=0.014]. CONCLUSION: NLR can be used as a predictive marker for the diagnosis of ACS. The study recommends using NLR as a simple, inexpensive, and widely available inflammatory marker which can be an auxiliary biomarker in the diagnosis of ACS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022b,

title = {Covid-19 vs dengue-role of WBC counts in segregation of cases at an early stage with special reference to NLR as a diagnostic and prognostic factor},

author = {Asiya Tabassum and Idrees Akhtar Afroze and Sumayya Begum },

url = {https://www.ijmsir.com/asset/images/uploads/16560077756647.pdf},

issn = {2458-868X},

year  = {2022},

date = {2022-05-31},

urldate = {2022-05-31},

journal = {International Journal of Medical Science and Innovative Research},

volume = {7},

issue = {3},

pages = {155-162},

abstract = {Both SARS-CoV and dengue virus can present as mild diseases which subsides by itself or can get severe resulting in a patient’s death. In tropical and subtropical countries, where dengue epidemics are commonly seen, COVID-19 can be easily misdiagnosed with dengue, because they present with common symptoms in the

initial stages but have different clinical management which makes it challenging for the health care  professionals to diagnose in the early stages. Moreover, there have been few cases reported where there was co infection by the viruses, making the picture still more confusing and challenging for the doctors. In poor and developing countries, access to specific diagnostic tests, the funding for them is limited and complete blood count (CBC) is the single most common test performed in patients. This study aimed to evaluate, analyse and compare the WBC count, differential leucocyte count and Neutrophil lymphocyte ratio (NLR) among COVID-19 and dengue cases. An attempt was made in diagnosing these two conditions with the above parameters at an early stage and to determine if further investigations or referrals would be required. Inflammatory marker NLR was also analyzed with series of samples of the patients during their hospital stay in predicting the outcome of cases. This study was a retrospective one done for duration of 1 year between Jan 2021 and Jan 2022 and included two different groups of patients, COVID-19 and dengue patients. A total of 106 cases of confirmed COVID-19 and 100 cases of dengue were included in the study. We propose utilizing the WBC count, differential count and NLR in early diagnosis and segregation of COVID 19 and dengue cases so that patients with COVID 19 can be isolated at the earliest, prompt treatment be given, decreasing the lead time, trying to combat the pandemic and the patients with dengue can be treated accordingly avoiding the complications. RT-PCR and dengue serology can be done on selected cases when required decreasing the burden on the health system and its resources. Patients with COVID-19 present with leucopenia or Leucocytosis, with Lymphopenia as the most significant finding, which is a useful and reliableindicator of the severity of the disease. Neutrophil lymphocyte ratio (NLR) was increased in majority of these cases and is described as an independent biomarker for indicating poor clinical outcomes in these patients. In contrast to COVID 19, the WBC count in dengue is characterized by progressive leucopenia with lymphocytic predominance and is associated with decreased NLR. Integrating the NLR in the diagnosis and prognosis of patients with COVID-19 and dengue would help in identification and prediction of cases with increased severity so that prompt treatment can be done

decreasing the mortality and for better outcome of these patients. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shamshuddeen_2022,

title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},

author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},

url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},

doi = {10.53730/ijhs.v6ns3.7623},

issn = {2550-696X},

year  = {2022},

date = {2022-05-20},

urldate = {2022-05-20},

journal = {International Journal of Health Sciences},

volume = {6},

issue = {S3},

pages = {6963-6971},

publisher = {Universidad Tecnica de Manabi},

abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Shamshuddeen_2022b,

title = {Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas},

author = {T. S. Shamshuddeen and Asiya Tabassum and Naushaba Tazeen and Idrees Akhtar Afroze},

url = {https://sciencescholar.us/journal/index.php/ijhs/article/view/7623/3841},

doi = {10.53730/ijhs.v6nS3.7623 },

issn = {2550-696X},

year  = {2022},

date = {2022-05-09},

urldate = {2022-05-09},

journal = {International Journal of Health Sciences},

volume = {6},

issue = {S3},

pages = {6963-6971},

abstract = {Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tabassum_2022,

title = {Evaluation of platelet indices in dengue seropositive cases at a tertiary care hospital in Hyderabad},

author = {Asiya Tabassum and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/evaluation-of-platelet-indices-in-dengue-seropositive-cases-at-a-tertiary-care-hospital-in-hyderabad-_January_2022_8361510941_2433857.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2022},

date = {2022-01-31},

urldate = {2022-01-31},

journal = {International Journal of Scientific Research},

volume = {11},

issue = {1},

pages = {48-49},

abstract = {Background: Dengue is caused by an arbovirus and is transmitted by mosquito Aedes aegypti. In addition to platelet count, Platelet indices like Mean platelet volume (MPV), Platelet distribution width (PDW) ,Plateletcrit (PCT ) and Platelet large cell ratio (P-LCR) are being investigated as prospective platelet activation indicators. Aims And Objectives: To evaluate the role of platelet indices in dengue seropositive cases. Materials And Methods: This study was a retrospective one conducted on dengue seropositive cases in Department of pathology, Deccan College of medical sciences, Hyderabad. Cases were collected from Dept of medicine and pediatrics over a period of 2 months in Oct-Nov 2021. Blood samples were processed on Sysmex XN 550 automated cell counter and platelet counts were cross checked manually. Results: In this study, Out of 350 samples received, 1OO patients were found to be positive for dengue serology. Male: Female ratio was 1.3:1 with average age being 7.5years .60 % cases had platelet counts below 50,000/cumm. Among platelet indices, 72 % of the patients had mean platelet volume (MPV) less than 8.5; 84 % cases had Plateletcrit less than 0.22 %; 80 % had platelet distribution width (PDW) more than 25  and P-LCR was increased in 56% cases. Conclusion: We observed signicant correlation of low platelet count with MPV, PCT, PDW and P-LCR. MPV is a marker of platelet function and activation, high MPV indicates increased megakaryocytic activity whereas low MPV indicates marrow suppression. PDW is an indicator of platelet anisocytosis and has a negative correlation with low platelet count. P-LCR is inversely related to platelet count and directly related to PDW. It is decreased in patients with thrombocytosis and increased in thrombocytopenia. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Asfiya_2021,

title = {Role of eosinophil count for early recognition and prognostication of Covid-19},

author = {Khanam Asfiya and Syed Mohammed Ali Mehdi and Idrees Akhtar Afroze and Fawwad M. Shaikh and Sumayya Begum and Nabila Afsar},

url = {https://www.ijmsir.com/asset/images/uploads/16281658002972.pdf},

issn = {2458-868X},

year  = {2021},

date = {2021-07-01},

urldate = {2021-07-01},

journal = {International Journal of Medical Science and Innovative Research},

volume = {6},

issue = {4},

pages = {224-232},

abstract = {Background: The Severe Respiratory Distress Syndrome caused by the COVID-19 virus has turned into a pandemic and has caused havoc worldwide and is still continuing to do so. In such times, there is a need for a diagnostic tool which eases the technique of detecting the disease and is also less time consuming. Thus an analogy was established between the Covid-19 positive RT-PCR cases and their blood eosinophil levels. Aims: To study the diagnostic and Prognostic significance of eosinophil counts in Covid-19 infections. Settings and Design: This study that was conducted in a tertiary health care centre was done by analysing the eosinophil counts of the patients and there by correlating them with the progression of the disease. Materials and Methods: 105 Patients who tested positive by RT-PCR for COVID-19 were enrolled for this study and their complete blood count report was obtained. Statistical Analysis: The data analysis was done in proportions and percentages. The statistical test of significance applied manually to the cross table was chi square test. Result: Based on the outcome it was noted that 70.50% cases were eosinopenic on admission. Also drop in eosinophil count(93.75% of the cases) or the absence of eosinophils on presentation correlated with poor prognosis. Conclusion: Eosinopenia can help in early detection of Covid-19 infection and the variation in the eosinophil count can help in gauging the prognosis and the outcome of the disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hussain_2021,

title = {Role of platelet-WBC ratio as a prognostic marker of cerebrovascular accident},

author = {Syed Arshad Hussain and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-plateletwbc-pwr-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_June_2021_6700252511_2520939.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2021},

date = {2021-06-01},

urldate = {2021-06-01},

journal = {International Journal of Scientific Research},

volume = {10},

issue = {6},

pages = {24-25},

abstract = {Cerebrovascular accidents are a leading cause of patient morbidity and mortality worldwide. The symptoms include sudden loss of vision,unconsciousness,weakness in contralateral upper and lower limbs, seizures and loss of vision. Several studies have concluded that the lower the platelet count and the higher the number of white blood cells in ischemic stroke patients will result in a more severe stroke and had worsen prognosis. Platelet and white blood cells counts can be converted into Platelet-to-White Blood Cell Ratio (PWR) which is a comparison between the number of platelets and white blood cells, so the higher PWR will provide better clinical outcomes. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Hussain_2021b,

title = {Role of neutrophil/lymphocyte ratio as a prognostic marker of cerebrovascular accident},

author = {Syed Arshad Hussain and Idrees Akhtar Afroze and T. S. Shamshuddeen},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-cerebrovascular-accident_May_2021_6510266714_9307901.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2021},

date = {2021-05-01},

urldate = {2021-05-01},

journal = {International Journal of Scientific Research},

volume = {10},

issue = {5},

pages = {76-77},

abstract = {NA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2020,

title = { Histopathological spectrum of endometrial biopsies in a tertiary care hospital: a retrospective institutional study},

author = {Mehveen Rahim Khan and Abdul Wase and Nabila Afsar and Atiya Begum},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/histopathological-spectrum-of-endometrial-biopsies-in-a-tertiary-care-hospital--a-retrospective-institutional-study_December_2020_0777706621_4527162.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-12-01},

urldate = {2020-12-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {12},

pages = {37-39},

abstract = {Endometrial biopsies are obtained for a number of reasons that include abnormal uterine bleeding in certain age groups, incomplete abortions, or suspected neoplasia and the endometrium may be sampled prior to certain procedures to treat infertility to determine the phase of the cycle to guide further tests or treatments. The study is a retrospective cross-sectional study carried out in the Department of Pathology of Owaisi hospital and research centre , on specimens received over a one-year period. 200 Samples of endometrial biopsies and curettings from women presenting with abnormal uterine bleeding received to the histopathology laboratory were analyzed. Patients were categorized into reproductive age groups (18-40 yrs), perimenopausal (41-50), and postmenopausal (>50yrs). Most common lesion is endometrial hyperplasia comprising 61% of total cases. The next common lesion is Endometrial polyp which accounts for 29% of total cases. 2 cases of Endometrial carcinoma were found which comprised of 1% of total cases. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Khan_2020b,

title = {Abdominal wall metastases of hepatocellular carcinoma-an unusual presentation},

author = {Mehveen Rahim Khan and Nabila Afsar and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/abdominal-wall-metastasis-of-hepatocellular-carcinomaan-unusual-presentation_November_2020_0418414166_1229394.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-11-01},

urldate = {2020-11-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {11},

pages = {52-53},

abstract = {We report a case of 60 year old male with a swelling in the right iliac fossa which presented as desmoid tumour clinically and was later found to be metastasis from hepatocellular carcinoma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Siddiqui_2020,

title = {Distribution of blood group type in diagnosed NS1Ag positive dengue patients in Hyderbad,Telangana State},

author = {Adiba Siddiqui and Nabiha Tabassum and Nabila Afsar and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2020/November/distribution-of-blood-group-type-in-diagnosed-ns1-ag-positive-dengue-patients-in-hyderabad-telengana-state-india_November_2020_7061945912_4335125.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-11-01},

urldate = {2020-11-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {11},

pages = {41-42},

abstract = {The aim of this study was to determine the distribution of blood group type in diagnosed NS1Ag positive dengue cases. The ABO phenotypes were identified by use of blood from patients with dengue virus infection prospectively, in newly diagnosed patients at a tertiary care hospital in south India. A total of 162 NS1Ag positive cases were collected with dengue illness. The greatest number (25%) of dengue cases were seen in the 11-20 year age group. Males were predominantly effected(58%). It was found that majority (45%) of cases belonged to blood group O.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afsar_2020,

title = {Role of neutrophil lymphocyte ratio as a prognostic marker of dengue},

author = {Nabila Afsar and Hina Sayeed and Fawwad M. Shaikh and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-neutrophil-lymphocyte-ratio-as-a-prognostic-marker-of-dengue_October_2020_6114171606_8732160.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-10-01},

urldate = {2020-10-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {10},

pages = {67-68},

abstract = {INTRODUCTION: Dengue is an important arthropod-borne viral infection in humans and is the second most important re-emerging tropical disease in the past 20 years all over the globe. Aim: To study neutrophil lymphocyte ratio in dengue cases and assess its role in relation with various demographic, serologic parameters and platelet count. MATERIAL AND METHODS: A retrospective study of 100 dengue cases admitted in a

tertiary care hospital in South India during the monsoon season of 2019 was carried out. Clinical data and CBC results were reviewed and analysed. The Chi Square test was used to compare categorical variables. RESULTS: Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. Neutrophil Lymphocyte

ratio(NLR) <2 strongly correlates with low platelets indicating severity of disease and reversal of NLR >2 correlates with improvement of disease. NLR <2 was more common in 0-20 years age group, younger the age lesser the Neutrophil Lymphocyte ratio and hence more severe the disease. CONCLUSION: Neutrophil Lymphocyte ratio acts as a prognostic indicator in dengue cases.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afreen_2020,

title = {Role of platelet parameters in acute coronary syndrome},

author = {Sobia Afreen and Nabila Afsar and Idrees Akhtar Afroze},

url = {https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/fileview/role-of-platelet-parameters-in-acute-coronary-syndrome_June_2020_1591092901_1816382.pdf},

doi = {10.36106/ijsr},

issn = {2277-8179},

year  = {2020},

date = {2020-06-01},

urldate = {2020-06-01},

journal = {International Journal of Scientific Research},

volume = {9},

issue = {6},

pages = {59-61},

abstract = {ACS is a set of signs and symptoms due to rupture of a plaque which is a consequence of platelet rich coronary thrombus formation. Thrombus leads to partial or complete coronary artery occlusion which inturn leads to myocardial ischemia and various clinical manifestation ranging from UA to acute myocardial infarction. Conventional risk factors include smoking, diabetes mellitus, hyperlipidemia, obesity and stress which either act

singly or in combination increase the chances of developing coronary atherosclerosis.4 Platelet indices also vary in diseases like diabetes, hypertension, obesity, hyperlipidemia etc.,5 This study aims to study the role of platelet parameters in patients with acute coronary syndrome and those who are at higher risk in comparison with healthy individuals. Conclusion: These larger platelets can be easily identified during routine hematological analysis. For this purpose, we think that MPV measurement, in which is a non-invasive and easily available test, it may be an important tool predicting an impending acute coronary event and helping in early intervention to manage such patients. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afsar_2019b,

title = {Anemia: a diagnostic malady in management of dengue patients},

author = {Nabila Afsar and Sabahat Zamani Nagma and Idrees Akhtar Afroze},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2542/1793},

doi = {10.21276/APALM.2542},

issn = {2349-6983},

year  = {2019},

date = {2019-12-28},

urldate = {2019-12-28},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {12},

pages = {A647-A652},

abstract = {Background: With the high prevalence of anemia and increasing incidence of dengue in developing countries like India, diagnosis of anemia in dengue patients needs to be stressed. There is higher hemoglobin and hematocrit as a result of plasma leakage in dengue; hence diagnosis and treatment of anemia may be missed. 

Methods:  A retrospective study was done on 138 dengue patients diagnosed in 2017, in a tertiary care teaching hospital in Hyderabad. The complete blood counts and blood picture data was retrieved and statistical analysis was performed using Microsoft Excel. Result:  60% of patients >5 yrs of age showed low hemoglobin while 93.3% showed hypochromia. In patients aged 5-11yrs and 12-14 yrs, 31.4% and 14.3% respectively had low hemoglobin, but hypochromia was noted in 48.6% and 57.1% .In non pregnant females, 68.4% 

showed low hemoglobin while 55.3% showed hypochromia. In males, 25% showed low hemoglobin whereas 13.9% showed hypochromia. Wide variability in hemoglobin concentration of same patient was noted with coefficient of variation above 1% in 91.7% of cases. MCV and MCH had coefficient of variation more than 1.1% and 0.5% in 25% and 69.4% of cases respectively. Conclusion:  Mean corpuscular volume is a stable parameter which can be used to assess the morphological status of the RBC even in a background of hemoconcentration where the hemoglobin is spuriously raised. The importance of inclusion of red cell indices especially mean corpuscular volume in complete blood counts reports is stressed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nagma_2019,

title = { Mixed connective tissue disease highlighting diagnostic exigency and treatment woes},

author = {Sabahat Zamani Nagma and Nabila Afsar and Idrees Akhtar Afroze and Atiya Begum},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2468/1758},

doi = {10.21276/APALM.2468},

issn = {2349-6983},

year  = {2019},

date = {2019-10-01},

urldate = {2019-10-01},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {9},

pages = {C97-C100},

abstract = {Mixed connective tissue disease (MCTD) is a rare connective tissue disease characterized by manifestations that overlap symptoms typical of several other inflammatory diseases of connective tissue. A presence of anti-ribonucleoprotein antibodies (antiU1RNP) in high titer is a typical immunological finding. A 20 year old female complained of chilling and cyanosis of fingers on cold exposure since 5 years, with pain and numbness, hardening of skin of both hands, episodes of Raynaud’s phenomenon,gangrenous changes, self amputation of distal digit of middle finger. Systemic manifestations were also associated. A 15 year old female complained of thickening and tightening of skin of face and hands since 5 months, associated with joint pains, shortness of breath, dysphagia and photosensitivity of skin. Both cases were positive for Anti U1-RNP and Anti-SSA/Ro52 antibodies. Serology, radiology and histopathology were performed. MCTD may be difficult to define as definite classification criteria are not fulfilled. Young and pediatric patients with skin manifestations must be investigated to initiate early treatment and monitor renal parameters. Patient compliance and trust in treating physician is a key to early diagnosis and treatment. Treating physician must recognize symptoms and refer patients to higher centres. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sultana_2019,

title = {Effects of cigarette smoking on erythrocyte sedimentation rate, platelet count, total and differential leucocyte counts in adult male smokers},

author = {Safia Sultana and Nabila Afsar and Mohammed Jawad and Mohammed Abdul Hannan Hazari},

url = {https://amphysiol.com/index.php/amp/article/view/v3i1.35185},

doi = {10.23921/amp.2019v3i1.35185},

issn = {2456-8422},

year  = {2019},

date = {2019-03-28},

urldate = {2019-03-28},

journal = {Annals of Medical Physiology},

volume = {3},

issue = {1},

pages = {14-18},

publisher = {Quench Academy of Medical Education and Research (QAMER) Publishing House},

abstract = {Smoking is one of the leading causes of death worldwide. Smokers have higher risk for coronary heart disease, atherosclerosis, acute myocardial infarction, hypertension, clotting disorders, inflammation, respiratory diseases, cancers, etc. A cigarette smoker is exposed to a number of harmful substances. In this study we hypothesized that smoking causes inflammatory reactions and induces hyperthrombic state in the body which may be reflected in erythrocyte sedimentation rate (ESR), total leucocyte count (TLC), differential leucocyte count (DLC) and platelet count values. The purpose of the study was to study the effects of cigarette smoking on erythrocyte sedimentation rate, total leucocyte count and platelet count in adult male smokers and to compare the results with non-smokers and to establish a relationship between the duration and quantity of smoking with the change in ESR, TLC, DLC and platelet count. A cross sectional study was conducted in the department of Pathology on 86 healthy male subjects (smokers=43 and non-smokers=43). ESR was estimated using Westergrens method. TLC, DLC and platelet counts were estimated using HORIBA Pentra ES60 autoanalyser. TLC and basophil counts were significantly higher in smokers than in non-smokers (p<0.05). The mean value of ESR was higher among smokers than non-smokers but it was statistically insignificant. Platelets counts showed no significant difference between smokers and non- smokers. No correlation was observed in various blood parameters and smoking (in pack years). We conclude that smoking initiates an inflammatory response as evidenced from raised TLC, monocyte and basophil counts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afsar_2019,

title = {Young immunocompetent individual positive for histoplasma capsulatum on bronchoalveolar lavage fluid cytology},

author = {Nabila Afsar and Maseera Zareen and Idrees Akhtar Afroze and Atiya Begum},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2348/1690},

doi = {10.21276/APALM.2348},

issn = {2349-6983},

year  = {2019},

date = {2019-03-16},

urldate = {2019-03-16},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {3},

pages = {C37-C39},

abstract = {Primary pulmonary histoplasmosis is a lung disease caused by dimorphic fungus Histoplasma Capsulatum. Bronchoalveolar fluid cytology is routinely performed as an inexpensive test even in under equipped laboratories. A 26 year old female, presented with persistent cough, evening rise of temperature and generalised weakness since 3 months and streaky hemoptysis since 3 weeks. CT showed consolidation in 

lower lobe of left lung and multiple mediastinal nodes in perivascular (aortic arch ) region and in sub carinal region. Bronchoscopy showed purulent exudates in lower lobe (6th segment of left lung). Bronchoalveolar lavage fluid was obtained and subjected to cytological evaluation and microbiological examination for Acid Fast bacillus. Cytosmears revealed macrophages with engulfed clusters of single walled yeast cells. The suspicion of Histoplasma was raised and the fluid was sent for fungal culture and Antigen testing was performed. Histoplasma Capsulatum can present in immunocompetent individuals and a strong suspicion must be made in patients with history of travel to endemic areas. Pathologist needs to look for the yeast cells even in immunocompetent individuals while routine screening of the BAL fluid cytosmears. Special staining may be resorted to, in individuals with high suspicion and positive history. Confirmation may be done by fungal 

cultures and antigen testing. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Farooqui_2019,

title = {Role and significance of hematological parameters in diabetes mellitus},

author = {Rafae Farooqui and Nabila Afsar and Idrees Akhtar Afroze},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/2355/1687},

doi = {0.21276/APALM.2355},

issn = {2349-6483},

year  = {2019},

date = {2019-03-16},

urldate = {2019-03-16},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {6},

issue = {3},

pages = {A158-A162},

abstract = {Background:  Diabetes mellitus is a global metabolic disorder characterized by persistent hyperglycemia and increased risk of microvascular and macrovascular complications. Consistent elevation of HbA1c can be associated with functional and structural changes in hemoglobin molecule, cytoplasmic viscosity and osmotic disturbances within red cell. These changes may be reflected in the red cell analytical parameters. Methods:

 120 subjects were studied. 41 were non diabetic healthy subjects (Group1). 79 were known diabetic patients, divided into two groups: HbA1c <7(39 subjects) Group 2 and HbA1c >7(40 subjects) Group 3. Sample for glucose estimation and CBC were collected in vacutainers containing sodium Fluoride and K 2EDTA respectively. Glucose, HbA1c and CBC estimation was carried out by auto analyzers. Result: Mean RBC count of diabetics with HbA1c<7 was less when compared to non-diabetic individuals.  Significant decrease was noted in the mean RBC count, Hb, HCT and MCV of diabetics with HbA1c>7 when compared to non diabetic individuals. There was significant decrease in mean Hb, HCT, MCV, MCH of diabetics with HbA1c >7 when compared to diabetics with HbA1c <7. Conclusion: The findings in the present study suggest that diabetic patients with poor control are more prone to develop anemia. This indicates a need for routine CBP examination for early detection and management of anemia in diabetic patients at the primary care setting to reduce associated morbidity due to lowered immunity associated with anemia and complications such as diabetic ketoacidosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Supriya_2018,

title = {Abnormal uterine bleeding: role of sonography and histopathology in endometrial study with emphasis on the organic causes},

author = {M. Supriya and Atiya Begum},

url = {https://www.ijpo.co.in/journal-article-file/6428},

doi = {10.18231/2394-6792.2018.0048},

issn = {2394-6784},

year  = {2018},

date = {2018-10-16},

urldate = {2018-10-16},

journal = {Indian Journal of Pathology and Oncology},

volume = {5},

issue = {2},

pages = {262-268},

abstract = {Introduction: Abnormal uterine bleeding (AUB) is the most common complaint in women of all age groups. The causes for abnormal bleeding needs to be evaluated before subjecting the patient to complicated surgical procedures. Transvaginal sonography is a simple outpatient procedure to identify suitable candidates for endometrial biopsy which provides an accurate diagnosis. Aims and Objectives: 1. To emphasize on the correlation of sonology and histopathological findings and to provide the cause of pathology for Abnormal Uterine Bleeding (AUB) in majority of cases. 2. To study the clinical data of the patients presenting with AUB and its histopathological spectrum. Materials and Methods: This was a prospective study conducted in the department of Pathology over a period of one year from January 2016 to December 2016. Endometrial biopsies of patients of all age groups presenting with a chief complaint of Abnormal uterine bleeding and abnormal USG findings were included in the study while inadequate biopsies and patients with genital infections, pregnancy–complications were excluded. The biopsies were processed as per the standard protocol. Histopathological examination was done and the diagnosis was given. Results were statistically analyzed. Results: A total of 87 cases were analyzed based on age, clinical presentation, parity, correlation of sonography-

histopathological findings was done and the results were found to have statistically significant p values.

Conclusion: A combination of sonography with histopathology provides an accurate diagnosis for AUB in most of the cases, specifically those with organic pathology. },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Supriya_2017,

title = {Dowling Degos disease: a clinicopathological study},

author = {M. Supriya and Syeda Naushaba Masood and Atiya Begum},

url = {https://www.rfppl.co.in/view_abstract.php?jid=10&art_id=6328},

doi = {10.21088/ijprp.2278.148X.6417.48},

issn = {2278-148X},

year  = {2017},

date = {2017-12-01},

urldate = {2017-12-01},

journal = {Indian Journal of Pathology: Research and Practice},

volume = {6},

number = {2},

issue = {4},

pages = {1114-1118},

abstract = {Background: DowlingDegos Disease (DDD) is a rare genetic disease of the skin having an autosomal dominant inheritance. It is grouped under reticulated pigmented anomalies and manifests as symmetric, progressive, pigmented macules over flexures, scattered comedolike lesions and pitted acneiform scars. Histopathology is required for definitive diagnosis and to distinguish it from other reticulate pigmentary genodermatoses. Aims: 1. To show the existence of this rare disease in the local population. (2) To stress on the clinicopathological correlation for the definitive diagnosis of the disease. Materials & Methods: Punch biopsies of skin received by the Department of Pathology over a span of two years with Dowling Degos Disease as one of the differential diagnosis, were included in the study. The biopsies were processed as per standard protocol. Diagnosis was confirmed by the histopathological examination. Result: A total of six cases were included in the study, out of which four were histologically confirmed as DDD and one case had features overlapping with Reticulate Acropigmentation of Kitamura (RAPK). The study showed female preponderance. Four cases had family history. The clinical and histopathological findings of each case are discussed. Conclusion: Dowling Degos Disease may not be a rare entity. It should be considered as one of the differential diagnoses for pigmentary disorders. With combined clinical and histopathological evaluation, more cases may come into light in the future and DDD may not remain as a rare disorder.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afsar_2017,

title = { Role of mean platelet volume as an adjunct in evaluation of acute inflammation},

author = {Nabila Afsar and Idrees Akhtar Afroze and Habeebunnisa Tahniath and Zakia Abid},

url = {https://www.pacificejournals.com/journal/index.php/apalm/article/view/apalm1486/pdf_416},

doi = {10.21276/APALM.1486},

issn = {2349-6483},

year  = {2017},

date = {2017-09-01},

urldate = {2017-09-01},

journal = {Annals of Pathology and Laboratory Medicine},

volume = {4},

issue = {4},

pages = {A466-A469},

abstract = {Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker.Methods:  A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis.Conclusion:  MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afroze_2015,

title = {A case of ambiguous genitalia diagnosed in a young male presenting clinically with left sided obstructed inguinal hernia},

author = {Idrees Akhtar Afroze and Fakeha Firdous and Syed Sibghatullah Quadri and Mohammed Abdul Majid Adil},

url = {https://www.statperson.com/Journal/ScienceAndTechnology/Article/Volume16Issue2/16_2_43.pdf},

issn = {2249-8109},

year  = {2015},

date = {2015-09-11},

urldate = {2015-09-11},

journal = {International Journal of Recent Trends in Science and Technology},

volume = {16},

issue = {2},

pages = {398-400},

abstract = {Ambiguous genetalia is a disorder of sex development (DSD). It occurs when something goes wrong during pregnancy to interrupt or disturb the fetus developing sex organs. Presence or absence of male hormones control the development of sex organs. A disruption of steps that determine sex can result in a mismatch between external genitals and internal sex organs or the chromosomal sex (xx or xy). Other causes can be mutations in certain genes or chromosomal abnormalities like missing sex chromosome or an extra one. Ambiguous genitalia is usually not life threatening, but can create social problem for the child and family.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kumar_2010b,

title = {Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model},

author = {Bhaskarpillai Santhosh Kumar and Santosh K. Tiwari and R. Saikant and G. Manoj and Amit Kunwar and G. Sivaram and Zakia Abid and Adeel Ahmad and K. Indira Priyadarsini and Aleem Ahmed Khan},

url = {https://doi.org/10.1016%2Fj.jtemb.2010.04.003},

doi = {10.1016/j.jtemb.2010.04.003},

year  = {2010},

date = {2010-10-01},

urldate = {2010-10-01},

journal = {Journal of Trace Elements in Medicine and Biology},

volume = {24},

issue = {4},

pages = {263-270},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tiwari_2010,

title = {Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels},

author = {Santosh K. Tiwari and G. Manoj and Vishwas Sharma and G. Sivaram and R. Saikant and Avinash Bardia and Varun K. Sharma and Zakia Abid and Aleem Ahmed Khan and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah and Bhaskarpillai Santhosh Kumar and Amrita Nandan},

url = {https://doi.org/10.1007%2Fs10787-010-0031-y},

doi = {10.1007/s10787-010-0031-y},

year  = {2010},

date = {2010-02-01},

urldate = {2010-02-01},

journal = {Inflammopharmacology},

volume = {18},

issue = {2},

pages = {59-64},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tiwari_2008,

title = {Prognostic significance of genotyping Helicobacter pylori infection in patients in younger age groups with gastric cancer},

author = {Santosh K. Tiwari and G. Manoj and G. Vasanth Kumar and G. Sivaram and Syed Ibrahim Hassan and B. Prabhakar and U. Devi and S. Jalaluddin and K. Kumar and S. Ahmed and Zakia Abid and Md. Aejaz Habeeb and Aleem Ahmed Khan and Chitoor Mohammed Habibullah},

url = {https://doi.org/10.1136%2Fpgmj.2007.065060},

doi = {10.1136/pgmj.2007.065060},

year  = {2008},

date = {2008-04-01},

urldate = {2008-04-01},

journal = {Postgraduate Medical Journal},

volume = {84},

issue = {990},

pages = {193-197},

publisher = {Oxford University Press (OUP)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Tiwari_2007,

title = {A simple multiplex PCR assay for diagnosing virulent Helicobacter pylori infection in human gastric biopsy specimens from subjects with gastric carcinoma and other gastro-duodenal diseases},

author = {Santosh K. Tiwari and Aleem Ahmed Khan and G. Manoj and S. Ahmed and Zakia Abid and Md. Aejaz Habeeb and Chitoor Mohammed Habibullah},

url = {https://doi.org/10.1111%2Fj.1365-2672.2007.03478.x},

doi = {10.1111/j.1365-2672.2007.03478.x},

year  = {2007},

date = {2007-09-01},

urldate = {2007-09-01},

journal = {Journal of Applied Microbiology},

volume = {103},

issue = {6},

pages = {2353-2360},

publisher = {Oxford University Press (OUP)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}